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4 results on '"Franco, Francesca Di"'

2. Deep learning‐based segmentation in prostate radiation therapy using Monte Carlo simulated cone‐beam CT

Author

Abbani, Nelly, Baudier, Thomas, Rit, Simon, Franco, Francesca Di, Okoli, Franklin, Jaouen, Vincent, Tilquin, Florian, Barateau, Anaïs, Simon, Antoine, de Crevoisier, Renaud, Bert, Julien, Sarrut, David, Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Traitement de l'Information Medicale (LaTIM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Département lmage et Traitement Information (IMT Atlantique - ITI), IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Grand Équipement National De Calcul Intensif, Agence Nationale de la Recherche, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Rit, Simon

Subjects
prostate, segmentation, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, CBCT, cancer, deep learning, Monte Carlo simulation
Abstract

International audience

Published
2022
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3. Dosimetric impact of intra-fraction prostate motion during moderate hypo-fractionated radiation treatment: a population-based study varying CTV-to-PTV margins

Author

Franco, Francesca Di, Baudier, Thomas, Gassa, F., Sarrut, David, Biston, Marie-Claude, and Rayet, Béatrice

Subjects
[PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [INFO.INFO-IM] Computer Science [cs]/Medical Imaging
Abstract

Introduction: Intrafraction organ motion during external beam radiotherapy can cause dosimetric inaccuracies. In particular, intrafraction prostate motion can be important for some patients (>1cm) and is known to potentially increase with session time. An accurate motion characterization may help determining the best compromise between optimal margins to increase tumor control and normal tissues’ sparing. The aim of this study was to investigate the dosimetric impact of intra-fractional motion during prostate radiation therapy providing a population-based margin for CTV-prostate basedon volumetric coverage.Methods: Prostate intra-fraction 3D translations were evaluated in 2400 sessions from 96 prostate cancer patients treated by radiation therapy in our institution with intra-fraction motion monitoring using Clarity transperineal ultrasound (TP-US) probe (Elekta AB, Stockholm). All patients underwent volumetric modulated arc therapy. The prescribed dose was 60 Gy in 20 fractions to the Clinical-Target-Volume (CTV) prostate and the treatment goal was that 100% of the prescribed dose must cover 99% of the CTV-prostate. Treatment durations ranged between 200-600s. For 18 randomly selectedpatients of the cohort (346 sessions) treatment plans were recomputed using 0, 3, 4, 5 and 6 mm CTVto-PTV margins, with an auto-planning optimization algorithm implemented in a research version of Monaco TPS (version 5.59.11, Elekta AB). This enabled assessing the impact of intrafraction motion on CTV coverage without operator variability in the planning process. Then, the voxel shifting method was used to move the CTV prostate structure every second of treatment, according to the movementsretrieved by the TP-US. The integrated shifting was then applied to the dose distribution maps and Dose-Volume Histograms (DVH) of the perturbed dose distributions were computed.Results: Mean intra-fraction prostate displacements observed were (0.02±0.39) mm, (0.38±0.74) mm and (-0.71±0.64) mm in left-right, supero-infero and antero-posterior directions, respectively. Mean displacements >3, 5 and 7 mm were observed for 16%, 5%, and 1% of the total fractions. Rare large deviations >8 mm were detected with a frequency

Published
2021

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