Search

Your search keyword '"Franco Di Monaco"' showing total 2 results
Start Over Author "Franco Di Monaco"
2 results on '"Franco Di Monaco"'

1. Complications post renal transplantation: literature focus on BK virus nephropathy and diagnostic tools actually available

Author

Franco Di Monaco, Umberto Miglio, Fernanda Chiarini, Monica Mischitelli, Valeria Pietropaolo, Elena Anzivino, Renzo Boldorini, Anna Bellizzi, and D. Fioriti

Subjects
Graft Rejection, viruses, MEDLINE, bk virus associated nephropathy (bkvan), human polyomavirus bk (bkv), Review, medicine.disease_cause, Nephropathy, lcsh:Infectious and parasitic diseases, Virology, Cystitis, medicine, Humans, lcsh:RC109-216, Kidney transplantation, Kidney, Polyomavirus Infections, business.industry, medicine.disease, Kidney Transplantation, BK virus, Transplantation, Tumor Virus Infections, medicine.anatomical_structure, Infectious Diseases, BK Virus, business, Medical literature
Abstract

Clinical diagnosis of kidney transplants related illnesses is not a simple task. Several studies were conducted to define diseases and complications after renal transplantation, but there are no comprehensive guidelines about diagnostic tools for their prevention and detection. The Authors of this review looked for the medical literature and pertinent publications in particular to understand the role of Human Polyomavirus BK (BKV) in renal failure and to recognize analytical techniques for BK virus associated nephropathy (BKVAN) detection.

Published
2008

2. p53 gene mutational rate, Gleason score, and BK virus infection in prostate adenocarcinoma: Is there a correlation?

Author

Franco Di Monaco, Valeria Pietropaolo, Laura Di Prospero, Franco Di Silverio, Monica Mischitelli, Giuseppe Russo, Antonio Giordano, Elena Anzivino, D. Fioriti, Patrizio Sale, Anna Bellizzi, and Anamaria Autran-Gomez

Subjects
Male, Pathology, medicine.medical_specialty, Cytoplasm, Tumor suppressor gene, viruses, Biology, Adenocarcinoma, Urine, medicine.disease_cause, Severity of Illness Index, Malignant transformation, Prostate cancer, Antigen, Virology, BK Virus Infection, medicine, Humans, Antigens, Viral, Tumor, Cell Nucleus, Polyomavirus Infections, Prostate, virus diseases, Cancer, Prostatic Neoplasms, medicine.disease, Genes, p53, BK virus, Tumor Virus Infections, Infectious Diseases, Real-time polymerase chain reaction, Blood, BK Virus, Tumor Suppressor Protein p53, bk virus, bkv-tag, gleason score, p53, p53 gene mutational rate, prostate cancer, quantitative pcr, viral neoplastic transformation
Abstract

Prostate cancer represents the second leading cause of cancer deaths in Western countries. Viral infections could play a role in prostate carcinogenesis. Human polyomavirus BK (BKV) is a possible candidate because of its transforming properties. In this study, BKV sequences in urine, blood, fresh, and paraffin-embedded prostate cancer samples from 26 patients were searched using Q-PCR analysis. T antigen (TAg) and p53 localization in neoplastic cells were evaluated by immunohistochemical analysis. Also, the presence of mutations in 5-9 exons of p53 gene was analyzed. Results showed that BKV-DNA was found in urine (54%), plasma (31%), and in fresh prostate cancer specimens (85%). The analysis of p53 gene evidenced several mutations in high Gleason patients, according to tumor advanced stage. Immunohistochemical analysis results evidenced the localization of p53 and TAg into cytoplasm, whereas in TAg-negative tumors, p53 was nuclear. This study suggests that BKV acts as cofactor in the pathogenesis of prostate cancer. These observations emphasize previous studies regarding the cellular pathways that may be deregulated by BKV.

Catalog

Books, media, physical & digital resources
See catalog results