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Your search keyword '"Franke, Eileen D."' showing total 30 results
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30 results on '"Franke, Eileen D."'

7. A randomized, double-blind, placebo-controlled, dose-ranging trial of tafenoquine for weekly prophylaxis against Plasmodium falciparum. (Major Article)

Author

Hale, Braden R., Owusu-Agyei, Seth, Fryauff, David J., Koram, Kwadwo A., Adjuik, Martin, Oduro, Abraham R., Prescott, W. Roy, Baird, J. Kevin, Nkrumah, Francis, Ritchie, Thomas L., Franke, Eileen D., Binka, Fred N., Horton, John, and Hoffman, Stephen L.

Subjects
GlaxoSmithKline PLC -- Product development, Malaria -- Prevention, Plasmodium falciparum -- Physiological aspects, Primaquine -- Usage, Pharmaceutical industry -- Product development, Health, Health care industry
Published
2003

13. A Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Ranging Trial of Tafenoquine for Weekly Prophylaxis againstPlasmodium falciparum

Author

Hale, Braden R., primary, Owusu‐Agyei, Seth, additional, Fryauff, David J., additional, Koram, Kwadwo A., additional, Adjuik, Martin, additional, Oduro, Abraham R., additional, Prescott, W. Roy, additional, Baird, J. Kevin, additional, Nkrumah, Francis, additional, Ritchie, Thomas L., additional, Franke, Eileen D., additional, Binka, Fred N., additional, Horton, John, additional, and Hoffman, Stephen L., additional

Published
2003
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24. Pancreatitis Induced by Pentavalent Antimonial Agents During Treatment of Leishmaniasis.

Author

Gasser, Robert A., Magill, Alan J., Oster, Charles N., Franke, Eileen D., Grögl, Max, and Berman, Jonathan D.

Abstract

Pentavalent antimony (Sbv), formulated as sodium stibogluconate or meglumine antimoniate, is the standard treatment for the leishmaniases. In 16 of 17 consecutive, prospectively observed patients in Washington D.C., serum levels of amylase and lipase rose to abnormal values after therapy with sodium stibogluconate was started; 12 of 17 had symptoms of pancreatitis. Sbv therapy was continued to completion in 7 of 17 patients and interrupted in 10 of 17. Pancreatitis improved in every patient after Sbv therapy was stopped. Sbv treatment was resumed after brief interruptions in 6 of 10 patients. All six of these patients had flares of pancreatitis, but each completed therapy. Subsequently, we measured amylase and lipase levels in stored sera from 32 patients treated in Peru with either sodium stibogluconate or meglumine antimoniate for mucosal leishmaniasis. In all 32 Peruvian patients, serum amylase and lipase rose to abnormal levels during Sbv therapy; 11 of 32 had symptoms of pancreatitis. Standard Sbv regimens induce pancreatitis in almost all patients, but continued therapy is often tolerated; pancreatitis subsides when therapy is stopped, and rechallenge may be tolerated after a brief halt in treatment. [ABSTRACT FROM PUBLISHER]

Published
1994

25. A Subdominant CD8+Cytotoxic T Lymphocyte (CTL) Epitope from the Plasmodium yoeliiCircumsporozoite Protein Induces CTLs That Eliminate Infected Hepatocytes from Culture

Author

Franke, Eileen D., Sette, Alessandro, Sacci, John, Southwood, Scott, Corradin, Giampietro, and Hoffman, Stephen L.

Abstract

ABSTRACTPrevious studies indicated that the Plasmodium yoeliicircumsporozoite protein (PyCSP) 57–70 region elicits T cells capable of eliminating infected hepatocytes in vitro. Herein, we report that the PyCSP58–67 sequence contains an H-2dbinding motif, which binds purified Kdmolecules in vitro with low affinity (3,267 nM) and encodes an H-2d-restricted cytotoxic T lymphocyte (CTL) epitope. Immunization of BALB/c mice with three doses of a multiple antigen peptide (MAP) construct containing four branches of amino acids 57 to 70 linked to a lysine-glycine core [MAP4(PyCSP57–70)] and Lipofectin as the adjuvant induced both T-cell proliferation and a peptide-specific CTL response that was PyCSP59–67 specific, H-2drestricted, and CD8+T cell dependent. Immunization with either DNA encoding the PyCSP or irradiated sporozoites demonstrated that this CTL epitope is subdominant since it is not recognized in the context of whole CSP immunization. The biological relevance of this CTL response was underlined by the demonstration that it could mediate genetically restricted, CD8+- and nitric-oxide-dependent elimination of infected hepatocytes in vitro, as well as partial protection of BALB/c mice against sporozoite challenge. These findings indicate that subdominant epitopes with low major histocompatibility complex affinity can be used to engineer epitope-based vaccines and have implications for the selection of epitopes for subunit-based vaccines.

Published
2000
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29. Immune Response of Humans to the Circumsporozoite Protein of Plasmodium falciparum: Limited T Cell Response to the Immunodominant Central Repeat Region

Author

Campbell, James R., primary, Annis, Barry A., additional, Kurniawan, Liliana, additional, Wasserman, Gail, additional, Wistar, Richard, additional, Franke, Eileen D., additional, Paleologo, Fred P., additional, Ratiwayanto, Sutanti, additional, Laughlin, Larry W., additional, Hoffman, Stephen L., additional, and Hadiputranto, Hilda, additional

Published
1988
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