1. The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder
- Author
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de Zwarte, Sonja MC, Brouwer, Rachel M, Agartz, Ingrid, Alda, Martin, Aleman, André, Alpert, Kathryn I, Bearden, Carrie E, Bertolino, Alessandro, Bois, Catherine, Bonvino, Aurora, Bramon, Elvira, Buimer, Elizabeth EL, Cahn, Wiepke, Cannon, Dara M, Cannon, Tyrone D, Caseras, Xavier, Castro-Fornieles, Josefina, Chen, Qiang, Chung, Yoonho, De la Serna, Elena, Di Giorgio, Annabella, Doucet, Gaelle E, Eker, Mehmet Cagdas, Erk, Susanne, Fears, Scott C, Foley, Sonya F, Frangou, Sophia, Frankland, Andrew, Fullerton, Janice M, Glahn, David C, Goghari, Vina M, Goldman, Aaron L, Gonul, Ali Saffet, Gruber, Oliver, de Haan, Lieuwe, Hajek, Tomas, Hawkins, Emma L, Heinz, Andreas, Hillegers, Manon HJ, Pol, Hilleke E Hulshoff, Hultman, Christina M, Ingvar, Martin, Johansson, Viktoria, Jönsson, Erik G, Kane, Fergus, Kempton, Matthew J, Koenis, Marinka MG, Kopecek, Miloslav, Krabbendam, Lydia, Krämer, Bernd, Lawrie, Stephen M, Lenroot, Rhoshel K, Marcelis, Machteld, Marsman, Jan-Bernard C, Mattay, Venkata S, McDonald, Colm, Meyer-Lindenberg, Andreas, Michielse, Stijn, Mitchell, Philip B, Moreno, Dolores, Murray, Robin M, Mwangi, Benson, Najt, Pablo, Neilson, Emma, Newport, Jason, van Os, Jim, Overs, Bronwyn, Ozerdem, Aysegul, Picchioni, Marco M, Richter, Anja, Roberts, Gloria, Aydogan, Aybala Saricicek, Schofield, Peter R, Simsek, Fatma, Soares, Jair C, Sugranyes, Gisela, Toulopoulou, Timothea, Tronchin, Giulia, Walter, Henrik, Wang, Lei, Weinberger, Daniel R, Whalley, Heather C, Yalin, Nefize, Andreassen, Ole A, Ching, Christopher RK, van Erp, Theo GM, Turner, Jessica A, Jahanshad, Neda, Thompson, Paul M, Kahn, René S, and van Haren, Neeltje EM
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Biological Psychology ,Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Psychology ,Mental Health ,Brain Disorders ,Serious Mental Illness ,Schizophrenia ,Genetics ,Neurosciences ,Clinical Research ,Bipolar Disorder ,2.3 Psychological ,social and economic factors ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Adult ,Brain ,Cohort Studies ,Female ,Genetic Predisposition to Disease ,Humans ,Male ,Middle Aged ,Young Adult ,Bipolar disorder ,Familial risk ,Imaging ,Meta-analysis ,Neurodevelopment ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Biological sciences ,Biomedical and clinical sciences - Abstract
BackgroundSchizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects.MethodsWe performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects.ResultsFDRs-BD had significantly larger ICV (d = +0.16, q < .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = -0.12, q < .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d
- Published
- 2019