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398 results on '"Franks N"'

1. GABA Receptors and the Pharmacology of Sleep

Author

Wisden, W., Yu, X., Franks, N. P., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Landolt, Hans-Peter, editor, and Dijk, Derk-Jan, editor

Published
2019
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36. Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness

Author

Yu, X, Ma, Y, Harding, E, Yustos, R, Vyssotski, A, Franks, N, Wisden, W, Wellcome Trust, and UK DRI Ltd

Subjects
BRAIN HISTAMINE, caspase, Clinical Neurology, histamine, histidine decarboxylase, modafinil, tuberomammillary nucleus, lesioning, chemogenetics, wakefulness, NREM sleep, AMPHETAMINE, TUBEROMAMMILLARY NUCLEUS, 11 Medical and Health Sciences, RELEASE, Science & Technology, Neurology & Neurosurgery, RECEPTOR, Neurosciences, NARCOLEPSY, 06 Biological Sciences, 17 Psychology and Cognitive Sciences, CORTICAL ACTIVATION, MICE, COGNITION, Neurosciences & Neurology, HYPOTHALAMUS, Life Sciences & Biomedicine, psychological phenomena and processes
Abstract

Acute chemogenetic inhibition of histamine (HA) neurons in adult mice induced nonrapid eye movement (NREM) sleep with an increased delta power. By contrast, selective genetic lesioning of HA neurons with caspase in adult mice exhibited a normal sleep–wake cycle overall, except at the diurnal start of the lights-off period, when they remained sleepier. The amount of time spent in NREM sleep and in the wake state in mice with lesioned HA neurons was unchanged over 24 hr, but the sleep–wake cycle was more fragmented. Both the delayed increase in wakefulness at the start of the night and the sleep–wake fragmentation are similar phenotypes to histidine decarboxylase knockout mice, which cannot synthesize HA. Chronic loss of HA neurons did not affect sleep homeostasis after sleep deprivation. However, the chronic loss of HA neurons or chemogenetic inhibition of HA neurons did notably reduce the ability of the wake-promoting compound modafinil to sustain wakefulness. Thus, part of modafinil’s wake-promoting actions arise through the HA system. ISSN:1550-9109 ISSN:0161-8105

Published
2019

37. Delayed xenon treatment prevents injury development following blast-neurotrauma in vitro

Author

Campos-Pires, R, Yonis, A, Pau, A, Macdonald, W, Harris, K, Franks, N, Edge, C, Dickinson, R, Royal Centre for Defence Medicine, British Journal of Anaesthesia, European Society of Anaesthesiology, Medical Research Council (MRC), and The Gas Safety Trust

Subjects
blast traumatic brain injury, Science & Technology, Neurology & Neurosurgery, Clinical Neurology, Neurosciences, 1103 Clinical Sciences, blast neurotrauma, xenon, Critical Care Medicine, General & Internal Medicine, novel treatments, Neurosciences & Neurology, 1109 Neurosciences, Life Sciences & Biomedicine
Published
2019

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