49 results on '"Frans, Emma"'
Search Results
2. Elevated symptoms of depression and anxiety among family members and friends of critically ill COVID-19 patients – an observational study of five cohorts across four countries
- Author
-
Lovik, Anikó, González-Hijón, Juan, Hoffart, Asle, Fawns-Ritchie, Chloe, Magnúsdóttir, Ingibjörg, Lu, Li, Unnarsdóttir, Anna Bára, Kähler, Anna K., Campbell, Archie, Hauksdóttir, Arna, Chourpiliadis, Charilaos, McCartney, Daniel L., Thordardóttir, Edda Björk, Joyce, Emily E., Frans, Emma M., Jakobsdóttir, Jóhanna, Trogstad, Lill, Andreassen, Ole A., Magnus, Per, Johnson, Sverre Urnes, Sullivan, Patrick F., Aspelund, Thor, Porteous, David J., Ask, Helga, Ebrahimi, Omid V., Valdimarsdóttir, Unnur Anna, and Fang, Fang
- Published
- 2023
- Full Text
- View/download PDF
3. Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: an observational study
- Author
-
Magnúsdóttir, Ingibjörg, Lovik, Anikó, Unnarsdóttir, Anna Bára, McCartney, Daniel, Ask, Helga, Kõiv, Kadri, Nordahl Christoffersen, Lea Arregui, Johnson, Sverre Urnes, McIntosh, Andrew, Kähler, Anna K., Campbell, Archie, Hauksdóttir, Arna, Fawns-Ritchie, Chloe, Erikstrup, Christian, Helenius, Dorte, Altschul, Drew, Thordardottir, Edda Bjork, Eyþórsson, Elías, Frans, Emma M., Tómasson, Gunnar, Jónsdóttir, Harpa Lind, Rúnarsdóttir, Harpa, Hjalgrim, Henrik, Harõardóttir, Hrönn, González-Hijón, Juan, Banasik, Karina, Dinh, Khoa Manh, Lu, Li, Milani, Lili, Trogstad, Lill, Didriksen, Maria, Ebrahimi, Omid V., Sullivan, Patrick F., Magnus, Per Minor, Shen, Qing, Nesvåg, Ragnar, Mägi, Reedik, Pálsson, Runólfur, Ostrowski, Sisse Rye, Werge, Thomas, Hoffart, Asle, Porteous, David J, Fang, Fang, Jakobsdóttir, Jóhanna, Lehto, Kelli, Andreassen, Ole A., Pedersen, Ole B.V., Aspelund, Thor, Valdimarsdóttir, Unnur Anna, Christoffersen, Lea Arregui Nordahl, Ebrahimi, Omid V, Andreassen, Ole A, and Pedersen, Ole B V
- Published
- 2022
- Full Text
- View/download PDF
4. Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data
- Author
-
Barker, Mary, primary, Kõiv, Kadri, additional, Magnúsdóttir, Ingibjörg, additional, Milbourn, Hannah, additional, Wang, Bin, additional, Du, Xinkai, additional, Murphy, Gillian, additional, Herweijer, Eva, additional, Gísladóttir, Elísabet, additional, Li, Huiqi, additional, Lovik, Anikó, additional, Kahler, Anna, additional, Campbell, Archie, additional, Feychting, Maria, additional, Hauksdóttir, Arna, additional, Joyce, Emily, additional, Thordardottir, Edda, additional, Frans, Emma, additional, Hoffart, Asle, additional, Magi, Reedik, additional, Tómasson, Gunnar, additional, Ásbjörnsdóttir, Kristjana, additional, Jakobsdóttir, Jóhanna, additional, Andreassen, Ole, additional, Sullivan, Patrick, additional, Johnson, Sverre, additional, Aspelund, Thor, additional, Brandlistuen, Ragnhild, additional, Ask, Helga, additional, McCartney, Daniel, additional, Ebrahimi, Omid, additional, Lehto, Kelli, additional, Valdimarsdóttir, Unnur, additional, Nyberg, Fredrik, additional, and Fang, Fang, additional
- Published
- 2024
- Full Text
- View/download PDF
5. Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data
- Author
-
Barker, Mary M, primary, Koiv, Kadri, additional, Magnusdottir, Ingibjorg, additional, Milbourn, Hannah, additional, Wang, Bin, additional, Du, Xinkai, additional, Murphy, Gillian, additional, Herweijer, Eva, additional, Gisladottir, Elisabet U, additional, Li, Huiqi, additional, Lovik, Aniko, additional, Kahler, Anna K, additional, Campbell, Archie, additional, Feychting, Maria, additional, Hauksdottir, Arna, additional, Joyce, Emily E, additional, Thordardottir, Edda Bjork, additional, Frans, Emma, additional, Hoffart, Asle, additional, Magi, Reedik, additional, Tomasson, Gunnar, additional, Asbjornsdottir, Kristjana, additional, Jakobsdottir, Johanna, additional, Andreassen, Ole, additional, Sullivan, Patrick, additional, Johnson, Sverre Urnes, additional, Aspelund, Thor, additional, Brandlistuen, Ragnhild Eek, additional, Ask, Helga, additional, McCartney, Daniel L., additional, Ebrahimi, Omid V, additional, Lehto, Kelli, additional, Valdimarsdottir, Unnur, additional, Nyberg, Fredrik, additional, and Fang, Fang, additional
- Published
- 2024
- Full Text
- View/download PDF
6. COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark
- Author
-
Shen, Qing, primary, Joyce, Emily E., additional, Ebrahimi, Omid V., additional, Didriksen, Maria, additional, Lovik, Anikó, additional, Sævarsdóttir, Karen Sól, additional, Magnúsdóttir, Ingibjörg, additional, Mikkelsen, Dorte Helenius, additional, Unnarsdóttir, Anna Bára, additional, Hauksdóttir, Arna, additional, Hoffart, Asle, additional, Kähler, Anna K., additional, Thórdardóttir, Edda Björk, additional, Eythórsson, Elías, additional, Frans, Emma M., additional, Tómasson, Gunnar, additional, Ask, Helga, additional, Hardardóttir, Hrönn, additional, Jakobsdóttir, Jóhanna, additional, Lehto, Kelli, additional, Lu, Li, additional, Andreassen, Ole A., additional, Sullivan, Patrick F., additional, Pálsson, Runólfur, additional, Erikstrup, Christian, additional, Ostrowski, Sisse Rye, additional, Werge, Thomas, additional, Aspelund, Thor, additional, Pedersen, Ole B.V., additional, Johnson, Sverre Urnes, additional, Fang, Fang, additional, and Valdimarsdóttir, Unnur Anna, additional
- Published
- 2023
- Full Text
- View/download PDF
7. Correction to : reply to Woodley of Menie et al.
- Author
-
Arslan, Ruben C., Willführ, Kai P., Frans, Emma M., Verweij, Karin J. H., Bürkner, Paul-Christian, Myrskylä, Mikko, Voland, Eckart, Almqvist, Catarina, Zietsch, Brendan P., and Penke, Lars
- Published
- 2018
8. Relaxed selection and mutation accumulation are best studied empirically : reply to Woodley of Menie et al.
- Author
-
Arslan, Ruben C., Willführ, Kai P., Frans, Emma M., Verweij, Karin J. H., Bürkner, Paul-Christian, Myrskylä, Mikko, Voland, Eckart, Almqvist, Catarina, Zietsch, Brendan P., and Penke, Lars
- Published
- 2018
9. Mental health indicators in Sweden over a 12-month period during the COVID-19 pandemic – Baseline data of the Omtanke2020 Study
- Author
-
Lovik, Anikó, González-Hijón, Juan, Kähler, Anna K., Valdimarsdóttir, Unnur A., Frans, Emma M., Magnusson, Patrik K.E., Pedersen, Nancy L., Hall, Per, Czene, Kamila, Sullivan, Patrick F., and Fang, Fang
- Subjects
Adult ,Sweden ,Psychiatry and Mental health ,Clinical Psychology ,Mental Health ,Cross-Sectional Studies ,SARS-CoV-2 ,Depression ,Humans ,COVID-19 ,Anxiety ,Pandemics ,Stress, Psychological - Abstract
The ongoing COVID-19 pandemic has had an unprecedented impact on the lives of people globally and is expected to have profound effects on mental health. Here we aim to describe the mental health burden experienced in Sweden using baseline data of the Omtanke2020 Study.We analysed self-reported, cross-sectional baseline data collected over a 12-month period (June 9, 2020-June 8, 2021) from the Omtanke2020 Study including 27,950 adults in Sweden. Participants were volunteers or actively recruited through existing cohorts and, after providing informed consent, responded to online questionnaires on socio-demographics, mental and physical health, as well as COVID-19 infection and impact. Poisson regression was fitted to assess the relative risk of demonstrating high level symptoms of depression, anxiety, and COVID-19 related distress.The proportion of persons with high level of symptoms was 15.6 %, 9.5 % and 24.5 % for depression, anxiety, and COVID-19 specific post-traumatic stress disorder (PTSD), respectively. Overall, 43.4 % of the participants had significant, clinically relevant symptoms for at least one of the three mental health outcomes and 7.3 % had significant symptoms for all three outcomes. We also observed differences in the prevalence of these outcomes across strata of sex, age, recruitment type, COVID-19 status, region, and seasonality.While the proportion of persons with high mental health burden remains higher than the ones reported in pre-pandemic publications, our estimates are lower than previously reported levels of depression, anxiety, and PTSD during the pandemic in Sweden and elsewhere.
- Published
- 2023
10. Reproductive stoppage in autism spectrum disorder in a population of 2.5 million individuals
- Author
-
Kuja-Halkola, Ralf, Larsson, Henrik, Lundström, Sebastian, Sandin, Sven, Chizarifard, Azadeh, Bölte, Sven, Lichtenstein, Paul, and Frans, Emma
- Published
- 2019
- Full Text
- View/download PDF
11. Elevated symptoms of depression and anxiety among family members of critically ill COVID-19 patients - An observational study of five cohorts across four countries
- Author
-
Lovik, Anikó, primary, González-Hijón, Juan, additional, Hoffart, Asle, additional, Fawns-Ritchie, Chloe, additional, Magnúsdóttir, Ingibjörg, additional, Lu, Li, additional, Unnarsdóttir, Anna Bára, additional, Kähler, Anna K., additional, Campbell, Archie, additional, Hauksdóttir, Arna, additional, Chourpiliadis, Charilaos, additional, McCartney, Daniel L., additional, Thordardóttir, Edda Björk, additional, Joyce, Emily E., additional, Frans, Emma M., additional, Jakobsdóttir, Jóhanna, additional, Trogstad, Lill, additional, Andreassen, Ole A., additional, Magnus, Per, additional, Johnson, Sverre Urnes, additional, Sullivan, Patrick F., additional, Aspelund, Thor, additional, Porteous, David J., additional, Ask, Helga, additional, Ebrahimi, Omid V., additional, Valdimarsdóttir, Unnur Anna, additional, and Fang, Fang, additional
- Published
- 2023
- Full Text
- View/download PDF
12. Short-term improvement of mental health after a COVID-19 vaccination
- Author
-
Chourpiliadis, Charilaos, primary, Lovik, Anikó, additional, Kähler, Anna K., additional, Valdimarsdóttir, Unnur A., additional, Frans, Emma M., additional, Nyberg, Fredrik, additional, Sullivan, Patrick F., additional, and Fang, Fang, additional
- Published
- 2023
- Full Text
- View/download PDF
13. COVID-19 illness severity and 2-year prevalence of physical symptoms:an observational study in Iceland, Sweden, Norway and Denmark
- Author
-
Shen, Qing, Joyce, Emily E., Ebrahimi, Omid V., Didriksen, Maria, Lovik, Anikó, Sævarsdóttir, Karen Sól, Magnúsdóttir, Ingibjörg, Mikkelsen, Dorte Helenius, Unnarsdóttir, Anna Bára, Hauksdóttir, Arna, Hoffart, Asle, Kähler, Anna K., Thórdardóttir, Edda Björk, Eythórsson, Elías, Frans, Emma M., Tómasson, Gunnar, Ask, Helga, Hardardóttir, Hrönn, Jakobsdóttir, Jóhanna, Lehto, Kelli, Lu, Li, Andreassen, Ole A., Sullivan, Patrick F., Pálsson, Runólfur, Erikstrup, Christian, Ostrowski, Sisse Rye, Werge, Thomas, Aspelund, Thor, Pedersen, Ole B. V., Johnson, Sverre Urnes, Fang, Fang, Valdimarsdóttir, Unnur Anna, Shen, Qing, Joyce, Emily E., Ebrahimi, Omid V., Didriksen, Maria, Lovik, Anikó, Sævarsdóttir, Karen Sól, Magnúsdóttir, Ingibjörg, Mikkelsen, Dorte Helenius, Unnarsdóttir, Anna Bára, Hauksdóttir, Arna, Hoffart, Asle, Kähler, Anna K., Thórdardóttir, Edda Björk, Eythórsson, Elías, Frans, Emma M., Tómasson, Gunnar, Ask, Helga, Hardardóttir, Hrönn, Jakobsdóttir, Jóhanna, Lehto, Kelli, Lu, Li, Andreassen, Ole A., Sullivan, Patrick F., Pálsson, Runólfur, Erikstrup, Christian, Ostrowski, Sisse Rye, Werge, Thomas, Aspelund, Thor, Pedersen, Ole B. V., Johnson, Sverre Urnes, Fang, Fang, and Valdimarsdóttir, Unnur Anna
- Abstract
Background: Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess the prevalence of physical symptoms in relation to acute illness severity up to more than 2-years after diagnosis of COVID-19. Methods: This multinational study included 64,880 adult participants from Iceland, Sweden, Denmark, and Norway with self-reported data on COVID-19 and physical symptoms from April 2020 to August 2022. We compared the prevalence of 15 physical symptoms, measured by the Patient Health Questionnaire (PHQ-15), among individuals with or without a confirmed COVID-19 diagnosis, by acute illness severity, and by time since diagnosis. We additionally assessed the change in symptoms in a subset of Swedish adults with repeated measures, before and after COVID-19 diagnosis. Findings: During up to 27 months of follow-up, 34.5% participants (22,382/64,880) were diagnosed with COVID-19. Individuals who were diagnosed with COVID-19, compared to those not diagnosed, had an overall 37% higher prevalence of severe physical symptom burden (PHQ-15 score ≥15, adjusted prevalence ratio [PR] 1.37 [95% confidence interval [CI] 1.23–1.52]). The prevalence was associated with acute COVID-19 severity: individuals bedridden for seven days or longer presented with the highest prevalence (PR 2.25 [1.85–2.74]), while individuals never bedridden presented with similar prevalence as individuals not diagnosed with COVID-19 (PR 0.92 [0.68–1.24]). The prevalence was statistically significantly elevated among individuals diagnosed with COVID-19 for eight of the fifteen measured symptoms: shortness of breath, chest pain, dizziness, heart racing, headaches, low energy/fatigue, trouble sleeping, and back pain. The analysis of repeated measurements rendered similar results as the main analysis. Interpretation: These data suggest an elevated prevalence of som
- Published
- 2023
14. Unravelling the link between sleep and mental health during the COVID‐19 pandemic.
- Author
-
González‐Hijón, Juan, Kähler, Anna K., Frans, Emma M., Valdimarsdóttir, Unnur A., Sullivan, Patrick F., Fang, Fang, and Lovik, Anikó
- Subjects
MENTAL illness risk factors ,SLEEP quality ,RESEARCH ,COVID-19 ,AGE distribution ,POPULATION geography ,RISK assessment ,SURVEYS ,SEX distribution ,SEASONS ,SLEEP duration ,SLEEP deprivation ,RESEARCH funding ,DESCRIPTIVE statistics ,STATISTICAL correlation ,COVID-19 pandemic ,MENTAL illness ,LONGITUDINAL method - Abstract
The emergence of COVID‐19 brought unparalleled changes in people's lifestyle, including sleep. We aimed to assess the bidirectional association between sleep quality and mental health and describe how sleep and mental health were affected in Sweden during the COVID‐19 pandemic (between June 2020 and September 2021). Data were obtained from the Omtanke2020 study. Participants who completed the baseline survey and each of the 8 monthly follow‐up surveys were included (N = 9035). We described the distribution of sleep and mental health in the different Swedish regions using maps and over the study period with longitudinal graphs adjusting for sex, age, recruitment type (self‐recruitment or invitation), and COVID‐19 status. The inner relationships between mental health, sleep and Covid infection were described through relative importance networks. Finally, we modelled how mental health affects sleep and vice versa using generalized estimating equations with different adjustments. Seasonal and north‐south regional variations were found in sleep and mental health outcomes at baseline and attenuated over time. The seasonal variation of sleep and mental health correlated moderately with the incidence rate of COVID‐19 in the sample. Networks indicate that the relationship between COVID‐19 incidence and mental health varies over time. We observed a bidirectional relationship between sleep quality and quantity at baseline and mental health at follow‐up and vice versa. Sleep quality and quantity at baseline was associated with adverse symptom trajectories of mental health at follow‐up, and vice versa, during the COVID‐19 pandemic. There was also a weak relationship between COVID‐19 incidence, sleep, and mental health. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
15. Cohort Profile:COVIDMENT: COVID-19 cohorts on mental health across six nations
- Author
-
Unnarsdóttir, Anna Bára, Lovik, Anikó, Fawns-Ritchie, Chloe, Ask, Helga, Kõiv, Kadri, Hagen, Kristen, Didriksen, Maria, Christoffersen, Lea Arregui Nordahl, Garðarsson, Alexander Berg, McIntosh, Andrew, Kähler, Anna K, Campbell, Archie, Hauksdóttir, Arna, Erikstrup, Christian, Mikkelsen, Dorte Helenius, Altschul, Drew, Thordardottir, Edda Bjork, Frans, Emma Maria, Kvale, Gerd, Tómasson, Gunnar, Kariis, Hanna Maria, Jónsdóttir, Harpa Lind, Rúnarsdóttir, Harpa, Magnúsdóttir, Ingibjörg, Eid, Jarle, Jakobsdóttir, Jóhanna, Nielsen, Kaspar René, Kaspersen, Kathrine Agergård, Milani, Lili, Trogstad, Lill-Iren Schou, Yi, Lu, Bruun, Mie Topholm, Sullivan, Patrick F, Magnus, Per Minor, Shen, Qing, Nesvåg, Ragnar, Brandlistuen, Ragnhild E, Mägi, Reedik, Ostrowski, Sisse Rye, Løkhammer, Solveig, Solem, Stian, Reichborn-Kjennerud, Ted, Hansen, Thomas Folkmann, Werge, Thomas, Aspelund, Thor, Porteous, David J, Fang, Fang, Lehto, Kelli, Andreassen, Ole A, Pedersen, Ole Birger Vesterager, Hellard, Stephanie Le, Valdimarsdóttir, Unnur A, Unnarsdóttir, Anna Bára, Lovik, Anikó, Fawns-Ritchie, Chloe, Ask, Helga, Kõiv, Kadri, Hagen, Kristen, Didriksen, Maria, Christoffersen, Lea Arregui Nordahl, Garðarsson, Alexander Berg, McIntosh, Andrew, Kähler, Anna K, Campbell, Archie, Hauksdóttir, Arna, Erikstrup, Christian, Mikkelsen, Dorte Helenius, Altschul, Drew, Thordardottir, Edda Bjork, Frans, Emma Maria, Kvale, Gerd, Tómasson, Gunnar, Kariis, Hanna Maria, Jónsdóttir, Harpa Lind, Rúnarsdóttir, Harpa, Magnúsdóttir, Ingibjörg, Eid, Jarle, Jakobsdóttir, Jóhanna, Nielsen, Kaspar René, Kaspersen, Kathrine Agergård, Milani, Lili, Trogstad, Lill-Iren Schou, Yi, Lu, Bruun, Mie Topholm, Sullivan, Patrick F, Magnus, Per Minor, Shen, Qing, Nesvåg, Ragnar, Brandlistuen, Ragnhild E, Mägi, Reedik, Ostrowski, Sisse Rye, Løkhammer, Solveig, Solem, Stian, Reichborn-Kjennerud, Ted, Hansen, Thomas Folkmann, Werge, Thomas, Aspelund, Thor, Porteous, David J, Fang, Fang, Lehto, Kelli, Andreassen, Ole A, Pedersen, Ole Birger Vesterager, Hellard, Stephanie Le, and Valdimarsdóttir, Unnur A
- Published
- 2022
16. Shared familial risk factors between autism spectrum disorder and obesity : a register‐based familial coaggregation cohort study
- Author
-
Ahlberg, Richard, Garcia-Argibay, Miguel, Hirvikoski, Tatja, Boman, Marcus, Chen, Qi, Taylor, Mark J., Frans, Emma, Bölte, Sven, Larsson, Henrik, Ahlberg, Richard, Garcia-Argibay, Miguel, Hirvikoski, Tatja, Boman, Marcus, Chen, Qi, Taylor, Mark J., Frans, Emma, Bölte, Sven, and Larsson, Henrik
- Abstract
Background: Meta-analyses suggest an association between autism spectrum disorder (ASD) and obesity, but the factors underlying this association remain unclear. This study investigated the association between ASD and obesity stratified on intellectual disability (ID). In addition, in order to gain insight into possible shared etiological factors, the potential role of shared familial liability was examined. Method: We studied a cohort of 3,141,696 individuals by linking several Swedish nationwide registers. We identified 35,461 individuals with ASD and 61,784 individuals with obesity. Logistic regression models were used to estimate the association between ASD and obesity separately by ID and sex and by adjusting for parental education, psychiatric comorbidity, and psychotropic medication. Potential shared familial etiologic factors were examined by comparing the risk of obesity in full siblings, maternal and paternal half-siblings, and full- and half-cousins of individuals with ASD to the risk of obesity in relatives of individuals without ASD. Results: Individuals with ASD + ID (OR = 3.76 [95% CI, 3.38-4.19]) and ASD-ID (OR = 3.40 [95% CI, 3.23-3.58]) had an increased risk for obesity compared with individuals without ASD. The associations remained statistically significant when adjusting for parental education, psychiatric comorbidity, and medication. Sex-stratified analyses indicated a higher relative risk for males compared with females, with statistically significant interaction effects for ASD-ID, but not for ASD+ID in the fully adjusted model. First-degree relatives of individuals with ASD+ID and ASD-ID had an increased risk of obesity compared with first-degree relatives of individuals without ASD. The obesity risk was similar in second-degree relatives of individuals with ASD+ID but was lower for and ASD-ID. Full cousins of individuals with ASD+ID had a higher risk compared with half-cousins of individuals with ASD+ID). A similar difference in the obesity
- Published
- 2022
- Full Text
- View/download PDF
17. Incidence of Genital Warts in Sweden Before and After Quadrivalent Human Papillomavirus Vaccine Availability
- Author
-
Leval, Amy, Herweijer, Eva, Arnheim-Dahlström, Lisen, Walum, Hasse, Frans, Emma, Sparén, Pär, and Simard, Julia F.
- Published
- 2012
- Full Text
- View/download PDF
18. Unravelling the link between sleep and mental health during the COVID-19 pandemic
- Author
-
Gonzalez-Hijon, Juan, primary, Kähler, Anna K, additional, Frans, Emma M, additional, Valdimarsdóttir, Unnur Anna, additional, Sullivan, Patrick F, additional, Fang, Fang, additional, and Lovik, Anikó, additional
- Published
- 2022
- Full Text
- View/download PDF
19. Short-term improvement of mental health after a COVID-19 vaccination
- Author
-
Chourpiliadis, Charilaos, primary, Lovik, Aniko, additional, Kahler, Anna K., additional, Valdimarsdottir, Unnur, additional, Frans, Emma M, additional, Nyberg, Fredrik, additional, Sullivan, Patrick F., additional, and Fang, Fang, additional
- Published
- 2022
- Full Text
- View/download PDF
20. Advanced paternal and grandpaternal age and schizophrenia: A three-generation perspective
- Author
-
Frans, Emma M., McGrath, John J., Sandin, Sven, Lichtenstein, Paul, Reichenberg, Abraham, Långström, Niklas, and Hultman, Christina M.
- Published
- 2011
- Full Text
- View/download PDF
21. Acute COVID-19 severity and 16-month mental morbidity trajectories in patient populations of six nations
- Author
-
Magnúsdóttir, Ingibjörg, primary, Lovik, Anikó, additional, Unnarsdóttir, Anna Bára, additional, McCartney, Daniel, additional, Ask, Helga, additional, Kõiv, Kadri, additional, Nordahl Christoffersen, Lea Arregui, additional, Johnson, Sverre Urnes, additional, McIntosh, Andrew, additional, Kähler, Anna K., additional, Campbell, Archie, additional, Hauksdóttir, Arna, additional, Fawns-Ritchie, Chloe, additional, Erikstrup, Christian, additional, Helenius, Dorte, additional, Altschul, Drew, additional, Thordardottir, Edda Bjork, additional, Eyþórsson, Elías, additional, Frans, Emma M., additional, Tómasson, Gunnar, additional, Jónsdóttir, Harpa Lind, additional, Rúnarsdóttir, Harpa, additional, Hjalgrim, Henrik, additional, Harðardóttir, Hrönn, additional, González-Hijón, Juan, additional, Banasik, Karina, additional, Dinh, Khoa Manh, additional, Lu, Li, additional, Milani, Lili, additional, Trogstad, Lill, additional, Didriksen, Maria, additional, Ebrahimi, Omid V., additional, Sullivan, Patrick F., additional, Magnus, Per Minor, additional, Shen, Qing, additional, Nesvåg, Ragnar, additional, Mägi, Reedik, additional, Pálsson, Runólfur, additional, Ostrowski, Sisse Rye, additional, Werge, Thomas, additional, Hoffart, Asle, additional, Porteous, David J, additional, Fang, Fang, additional, Jakobsdóttir, Jóhanna, additional, Lehto, Kelli, additional, Andreassen, Ole A, additional, Pedersen, Ole B. V., additional, Aspelund, Thor, additional, and Valdimarsdóttir, Unnur Anna, additional
- Published
- 2021
- Full Text
- View/download PDF
22. Mental health indicators in Sweden over a 12-month period during the COVID-19 pandemic
- Author
-
Lovik, Anikó, primary, González-Hijón, Juan, additional, Kähler, Anna K., additional, Valdimarsdóttir, Unnur A., additional, Frans, Emma M., additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Hall, Per, additional, Czene, Kamila, additional, Sullivan, Patrick F., additional, and Fang, Fang, additional
- Published
- 2021
- Full Text
- View/download PDF
23. Shared familial risk factors between autism spectrum disorder and obesity – a register‐based familial coaggregation cohort study
- Author
-
Ahlberg, Richard, primary, Garcia‐Argibay, Miguel, additional, Hirvikoski, Tatja, additional, Boman, Marcus, additional, Chen, Qi, additional, Taylor, Mark J., additional, Frans, Emma, additional, Bölte, Sven, additional, and Larsson, Henrik, additional
- Published
- 2021
- Full Text
- View/download PDF
24. Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations
- Author
-
Unnarsdóttir, Anna Bára, primary, Lovik, Anikó , additional, Fawns-Ritchie, Chloe, additional, Ask, Helga, additional, Kõiv, Kadri, additional, Hagen, Kristen, additional, Didriksen, Maria, additional, Christoffersen, Lea Arregui Nordahl, additional, Garðarsson, Alexander Berg, additional, McIntosh, Andrew, additional, Kähler, Anna K, additional, Campbell, Archie, additional, Hauksdóttir, Arna, additional, Erikstrup, Christian, additional, Mikkelsen, Dorte Helenius, additional, Altschul, Drew, additional, Thordardottir, Edda Bjork, additional, Frans, Emma Maria, additional, Kvale, Gerd, additional, Tómasson, Gunnar, additional, Kariis, Hanna Maria, additional, Jónsdóttir, Harpa Lind, additional, Rúnarsdóttir, Harpa, additional, Magnúsdóttir, Ingibjörg, additional, Eid, Jarle, additional, Jakobsdóttir, Jóhanna, additional, Nielsen, Kaspar René, additional, Kaspersen, Kathrine Agergård, additional, Milani, Lili, additional, Trogstad, Lill-Iren Schou, additional, Yi, Lu, additional, Bruun, Mie Topholm, additional, Sullivan, Patrick F, additional, Magnus, Per Minor, additional, Shen, Qing, additional, Nesvåg, Ragnar, additional, Brandlistuen, Ragnhild E, additional, Mägi, Reedik, additional, Ostrowski, Sisse Rye, additional, Løkhammer, Solveig, additional, Solem, Stian, additional, Reichborn-Kjennerud, Ted, additional, Hansen, Thomas Folkmann, additional, Werge, Thomas, additional, Aspelund, Thor, additional, Porteous, David J, additional, Fang, Fang, additional, Lehto, Kelli, additional, Andreassen, Ole A, additional, Pedersen, Ole Birger Vesterager, additional, Hellard, Stephanie Le, additional, and Valdimarsdóttir, Unnur A, additional
- Published
- 2021
- Full Text
- View/download PDF
25. Shared familial risk factors between autism spectrum disorder and obesity : a register‐based familial coaggregation cohort study
- Author
-
Ahlberg, Richard, Garcia-Argibay, Miguel, Hirvikoski, Tatja, Boman, Marcus, Chen, Qi, Taylor, Mark J., Frans, Emma, Bölte, Sven, Larsson, Henrik, Ahlberg, Richard, Garcia-Argibay, Miguel, Hirvikoski, Tatja, Boman, Marcus, Chen, Qi, Taylor, Mark J., Frans, Emma, Bölte, Sven, and Larsson, Henrik
- Abstract
Background: Meta-analyses suggest an association between autism spectrum disorder (ASD) and obesity, but the factors underlying this association remain unclear. This study investigated the association between ASD and obesity stratified on intellectual disability (ID). In addition, in order to gain insight into possible shared etiological factors, the potential role of shared familial liability was examined. Method: We studied a cohort of 3,141,696 individuals by linking several Swedish nationwide registers. We identified 35,461 individuals with ASD and 61,784 individuals with obesity. Logistic regression models were used to estimate the association between ASD and obesity separately by ID and sex and by adjusting for parental education, psychiatric comorbidity, and psychotropic medication. Potential shared familial etiologic factors were examined by comparing the risk of obesity in full siblings, maternal and paternal half-siblings, and full- and half-cousins of individuals with ASD to the risk of obesity in relatives of individuals without ASD. Results: Individuals with ASD + ID (OR = 3.76 [95% CI, 3.38-4.19]) and ASD-ID (OR = 3.40 [95% CI, 3.23-3.58]) had an increased risk for obesity compared with individuals without ASD. The associations remained statistically significant when adjusting for parental education, psychiatric comorbidity, and medication. Sex-stratified analyses indicated a higher relative risk for males compared with females, with statistically significant interaction effects for ASD-ID, but not for ASD+ID in the fully adjusted model. First-degree relatives of individuals with ASD+ID and ASD-ID had an increased risk of obesity compared with first-degree relatives of individuals without ASD. The obesity risk was similar in second-degree relatives of individuals with ASD+ID but was lower for and ASD-ID. Full cousins of individuals with ASD+ID had a higher risk compared with half-cousins of individuals with ASD+ID). A similar difference in the obesity
- Published
- 2021
- Full Text
- View/download PDF
26. Paternal Age at Childbearing and Offspring Psychiatric and Academic Morbidity
- Author
-
D’Onofrio, Brian M., Rickert, Martin E., Frans, Emma, Kuja-Halkola, Ralf, Almqvist, Catarina, Sjölander, Arvid, Larsson, Henrik, and Lichtenstein, Paul
- Published
- 2014
- Full Text
- View/download PDF
27. Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations.
- Author
-
Unnarsdóttir, Anna Bára, Lovik, Anikó, Fawns-Ritchie, Chloe, Ask, Helga, Kõiv, Kadri, Hagen, Kristen, Didriksen, Maria, Christoffersen, Lea Arregui Nordahl, Garðarsson, Alexander Berg, McIntosh, Andrew, Kähler, Anna K, Campbell, Archie, Hauksdóttir, Arna, Erikstrup, Christian, Mikkelsen, Dorte Helenius, Altschul, Drew, Thordardottir, Edda Bjork, Frans, Emma Maria, Kvale, Gerd, and Tómasson, Gunnar
- Published
- 2022
- Full Text
- View/download PDF
28. Advancing paternal age and bipolar disorder
- Author
-
Frans, Emma M., Sandin, Sven, Reichenberg, Abraham, Lichtenstein, Paul, Langstrom, Niklas, and Hultman, Christina M.
- Subjects
Bipolar disorder -- Risk factors ,Bipolar disorder -- Research ,Parental influences -- Research ,Health ,Psychology and mental health - Published
- 2008
29. Association between parental age and asthma in a population-based register study
- Author
-
Almqvist, Catarina, Olsson, Henrik, Ullemar, Vilhelmina, DʼOnofrio, Brian M., Frans, Emma, and Lundholm, Cecilia
- Published
- 2015
- Full Text
- View/download PDF
30. Autism Risk Across Generations: A Population-Based Study of Advancing Grandpaternal and Paternal Age
- Author
-
Frans, Emma M., Sandin, Sven, Reichenberg, Abraham, Långström, Niklas, Lichtenstein, Paul, McGrath, John J., and Hultman, Christina M.
- Published
- 2013
- Full Text
- View/download PDF
31. MOESM1 of Reproductive stoppage in autism spectrum disorder in a population of 2.5 million individuals
- Author
-
Kuja-Halkola, Ralf, Larsson, Henrik, Lundström, Sebastian, Sandin, Sven, Azadeh Chizarifard, Bölte, Sven, Lichtenstein, Paul, and Frans, Emma
- Abstract
Additional file 1: Figures S1–S3 and Table S1. Supplementary figures and tables.
- Published
- 2019
- Full Text
- View/download PDF
32. Model documentation, reproductive timing from Older fathers' children have lower evolutionary fitness across four centuries and in four populations
- Author
-
Arslan, Ruben C., Willführ, Kai P., Frans, Emma M., Verweij, Karin J. H., Paul-Christian Bürkner, Myrskylä, Mikko, Voland, Eckart, Almqvist, Catarina, Zietsch, Brendan P., and Penke, Lars
- Subjects
sense organs ,skin and connective tissue diseases - Abstract
Documentation of the main models, the infant survival models, details of the robustness analyses and details on reproductive timing changes in Sweden.
- Published
- 2017
- Full Text
- View/download PDF
33. Association between parental age and asthma in a population-based register study
- Author
-
Almqvist, Catarina, Olsson, Henrik, Ullemar, Vilhelmina, D'Onofrio, Brian M, Frans, Emma, Lundholm, Cecilia, Almqvist, Catarina, Olsson, Henrik, Ullemar, Vilhelmina, D'Onofrio, Brian M, Frans, Emma, and Lundholm, Cecilia
- Abstract
In a nationwide population-based study with family design, we found an association between decreasing parental age and asthma in early childhood. The effect was independent of familial and potentially confounding factors.
- Published
- 2017
34. A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette’s/chronic tic disorders
- Author
-
Mataix-Cols, David, Frans, Emma, Pérez-Vigil, Ana, Kuja-Halkola, Ralf, Gromark, Caroline, Isomura, Kayoko, Fernández de la Cruz, Lorena, Serlachius, Eva, Leckman, James F, Crowley, James J, Rück, Christian, Almqvist, Catarina, Lichtenstein, Paul, Larsson, Henrik, Mataix-Cols, David, Frans, Emma, Pérez-Vigil, Ana, Kuja-Halkola, Ralf, Gromark, Caroline, Isomura, Kayoko, Fernández de la Cruz, Lorena, Serlachius, Eva, Leckman, James F, Crowley, James J, Rück, Christian, Almqvist, Catarina, Lichtenstein, Paul, and Larsson, Henrik
- Abstract
The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity and familial clustering of a broad range of ADs in individuals with OCD, individuals with TD/CTD and their biological relatives. From a birth cohort of 7 465 455 individuals born in Sweden between 1940 and 2007, we identified 30 082 OCD and 7279 TD/CTD cases in the National Patient Register and followed them up to 31 December 2013. The risk of 40 ADs was evaluated in individuals with OCD, individuals with TD/CTD and their first- (siblings, mothers, fathers), second- (half siblings) and third-degree (cousins) relatives, compared with population controls. Individuals with OCD and TD/CTD had increased comorbidity with any AD (43% and 36%, respectively) and many individual ADs. The risk of any AD and several individual ADs was consistently higher among first-degree relatives than among second- and third-degree relatives of OCD and TD/CTD probands. The risk of ADs was very similar in mothers, fathers and siblings of OCD probands, whereas it tended to be higher in mothers and fathers of TD/CTD probands (compared with siblings). The results suggest a familial link between ADs in general (that is, not limited to Streptococcus-related conditions) and both OCD and TD/CTD. Additional mother-specific factors, such as the placental transmission of antibodies, cannot be fully ruled out, particularly in TD/CTD.
- Published
- 2017
35. Older fathers' children have lower evolutionary fitness across four centuries and in four populations
- Author
-
Arslan, Ruben C., primary, Willführ, Kai P., additional, Frans, Emma M., additional, Verweij, Karin J. H., additional, Bürkner, Paul-Christian, additional, Myrskylä, Mikko, additional, Voland, Eckart, additional, Almqvist, Catarina, additional, Zietsch, Brendan P., additional, and Penke, Lars, additional
- Published
- 2017
- Full Text
- View/download PDF
36. The Importance of Immune System Diseases in the Etiology of Attention-Deficit/Hyperactivity Disorder
- Author
-
Frans, Emma Maria, primary
- Published
- 2017
- Full Text
- View/download PDF
37. Older fathers' children have lower evolutionary fitness across four centuries and in four populations
- Author
-
Arslan, Ruben C., primary, Willführ, Kai P., additional, Frans, Emma, additional, Verweij, Karin J. H., additional, Myrskylä, Mikko, additional, Voland, Eckart, additional, Almqvist, Catarina, additional, Zietsch, Brendan P., additional, and Penke, Lars, additional
- Published
- 2016
- Full Text
- View/download PDF
38. Advancing paternal age and psychiatric disorders
- Author
-
Frans, Emma, primary, MacCabe, James H., additional, and Reichenberg, Abraham, additional
- Published
- 2015
- Full Text
- View/download PDF
39. Paternal age at childbearing and offspring psychiatric and academic morbidity
- Author
-
D'Onofrio, Brian M., Rickert, Martin E., Frans, Emma, Kuja-Halkola, Ralf, Almqvist, Catarina, Sjölander, Arvid, Larsson, Henrik, Lichtenstein, Paul, D'Onofrio, Brian M., Rickert, Martin E., Frans, Emma, Kuja-Halkola, Ralf, Almqvist, Catarina, Sjölander, Arvid, Larsson, Henrik, and Lichtenstein, Paul
- Abstract
Importance: Advancing paternal age is associated with increased genetic mutations during spermatogenesis, which research suggests may cause psychiatric morbidity in the offspring. The effects of advancing paternal age at childbearing on offspring morbidity remain unclear, however, because of inconsistent epidemiologic findings and the inability of previous studies to rigorously rule out confounding factors. Objective: To examine the associations between advancing paternal age at childbearing and numerous indexes of offspring morbidity. Design, setting and participants: We performed a population-based cohort study of all individuals born in Sweden in 1973-2001 (N = 2,615,081), with subsets of the data used to predict childhood or adolescent morbidity. We estimated the risk of psychiatric and academic morbidity associated with advancing paternal age using several quasi-experimental designs, including the comparison of differentially exposed siblings, cousins, and first-born cousins. Exposure: Paternal age at childbearing. Main outcomes and measures: Psychiatric (autism, attention-deficit/hyperactivity disorder, psychosis, bipolar disorder, suicide attempt, and substance use problem) and academic (failing grades and low educational attainment) morbidity. Results: In the study population, advancing paternal age was associated with increased risk of some psychiatric disorders (eg, autism, psychosis, and bipolar disorders) but decreased risk of the other indexes of morbidity. In contrast, the sibling-comparison analyses indicated that advancing paternal age had a dose-response relationship with every index of morbidity, with the magnitude of the associations being as large or larger than the estimates in the entire population. Compared with offspring born to fathers 20 to 24 years old, offspring of fathers 45 years and older were at heightened risk of autism (hazard ratio [HR] = 3.45; 95% CI, 1.62-7.33), attention-deficit/hyperactivity disorder (HR = 13.13; 95% CI, 6.85-2, Funding Agencies:National Institute of Child Health and Human Development Swedish Council for Working Life and Social Research
- Published
- 2014
- Full Text
- View/download PDF
40. High paternal age and risk of psychiatric disorders in offspring
- Author
-
Frans, Emma and Frans, Emma
- Abstract
Parental ages at childbirth are increasing all over the world and later parenthood might have negative health outcomes for the offspring. During recent year, numerous studies report links between and high paternal age and psychiatric disorders such as schizophrenia and autism. However, the knowledge about this association is limited. The aim of this thesis was to gain valuable knowledge about the paternal age effect regarding its specificity, transmission and mechanism. The studies were conducted in an epidemiological setting by using multiple large population-based data sources that also enable controlling for a range of documented risk factors including parental, perinatal and socioeconomic variables. In our first study we reported, for the first time, that high paternal age also is associated with bipolar disorder. The risk increased monotonically with age of the father and was, compared to younger men, highest in offspring of men in the oldest age category including men aged 55 years and older (odds ratio =1.37) after adjustments. It was also evident that the paternal age effect was stronger when only analyzing individuals with an early disorder onset. In study II, we confirmed an association between advancing paternal age and autism in the offspring. More importantly, we found an association between advancing paternal age and autism risk in the grandchild. Compared to younger fathers, men who fathered a daughter when they were 50 years or older were 1.79 times more likely to have a grandchild with autism, and men who father a son at 50 years of age or older were 1.67 times more likely to have an affected grandchild. An increased burden of rare copy number variants (CNVs) has been found in individuals with schizophrenia and it has been suggested that CNVs can arise during replication. In study III, we used a sample consisting of individuals affected with schizophrenia and matched controls and examined paternal age in relation to rare CNVs. Although we found that
- Published
- 2013
41. Paternal age and offspring fitness: online supplementary website
- Author
-
Arslan, Ruben C., Willführ, Kai P., Frans, Emma, Verweij, Karin J. H., Myrskylä, Mikko, Voland, Eckart, Almqvist, Catarina, Zietsch, Brendan, and Penke, Lars
- Subjects
paternal age ,reproductive success ,genetic load ,evolutionary fitness ,mutation ,3. Good health - Abstract
Paternal age effects on offspring fitness in four populations - online supplementary website - see https://rubenarslan.github.io/paternal_age_fitness for browsable site.
42. Correction to: reply to Woodley of Menie et al.
- Author
-
Arslan, Ruben C., Willführ, Kai P., Frans, Emma M., Verweij, Karin J. H., Bürkner, Paul-Christian, Myrskylä, Mikko, Voland, Eckart, Almqvist, Catarina, Zietsch, Brendan P., Penke, Lars, Arslan, Ruben C., Willführ, Kai P., Frans, Emma M., Verweij, Karin J. H., Bürkner, Paul-Christian, Myrskylä, Mikko, Voland, Eckart, Almqvist, Catarina, Zietsch, Brendan P., and Penke, Lars
43. Relaxed selection and mutation accumulation are best studied empirically: reply to Woodley of Menie et al
- Author
-
Arslan, Ruben C., Willführ, Kai P., Frans, Emma M., Verweij, Karin J. H., Bürkner, Paul-Christian, Myrskylä, Mikko, Voland, Eckart, Almqvist, Catarina, Zietsch, Brendan P., Penke, Lars, Arslan, Ruben C., Willführ, Kai P., Frans, Emma M., Verweij, Karin J. H., Bürkner, Paul-Christian, Myrskylä, Mikko, Voland, Eckart, Almqvist, Catarina, Zietsch, Brendan P., and Penke, Lars
44. Older fathers’ children have lower evolutionary fitness across four centuries and in four populations
- Author
-
Arslan, Ruben C., Willführ, Kai P., Frans, Emma M., Verweij, Karin J. H., Bürkner, Paul-Christian, Myrskylä, Mikko, Voland, Eckart, Almqvist, Catarina, Zietsch, Brendan P., Penke, Lars, Arslan, Ruben C., Willführ, Kai P., Frans, Emma M., Verweij, Karin J. H., Bürkner, Paul-Christian, Myrskylä, Mikko, Voland, Eckart, Almqvist, Catarina, Zietsch, Brendan P., and Penke, Lars
- Abstract
Higher paternal age at offspring conception increases de novo genetic mutations. Based on evolutionary genetic theory we predicted older fathers’ children, all else equal, would be less likely to survive and reproduce, i.e. have lower fitness. In sibling control studies, we find support for negative paternal age effects on offspring survival and reproductive success across four large populations with an aggregate N > 1.4 million. Three populations were pre-industrial (1670-1850) Western populations and showed negative paternal age effects on infant survival and offspring reproductive success. In 20th-century Sweden, we found minuscule paternal age effects on survival, but found negative effects on reproductive success. Effects survived tests for key competing explanations, including maternal age and parental loss, but effects varied widely over different plausible model specifications and some competing explanations such as diminishing paternal investment and epigenetic mutations could not be tested. We can use our findings to aid in predicting the effect increasingly older parents in today’s society will have on their children’s survival and reproductive success. To the extent that we succeeded in isolating a mutation-driven effect of paternal age, our results can be understood to show that de novo mutations reduce offspring fitness across populations and time periods.
45. COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark.
- Author
-
Shen Q, Joyce EE, Ebrahimi OV, Didriksen M, Lovik A, Sævarsdóttir KS, Magnúsdóttir I, Mikkelsen DH, Unnarsdóttir AB, Hauksdóttir A, Hoffart A, Kähler AK, Thórdardóttir EB, Eythórsson E, Frans EM, Tómasson G, Ask H, Hardardóttir H, Jakobsdóttir J, Lehto K, Lu L, Andreassen OA, Sullivan PF, Pálsson R, Erikstrup C, Ostrowski SR, Werge T, Aspelund T, Pedersen OBV, Johnson SU, Fang F, and Valdimarsdóttir UA
- Abstract
Background: Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess the prevalence of physical symptoms in relation to acute illness severity up to more than 2-years after diagnosis of COVID-19., Methods: This multinational study included 64,880 adult participants from Iceland, Sweden, Denmark, and Norway with self-reported data on COVID-19 and physical symptoms from April 2020 to August 2022. We compared the prevalence of 15 physical symptoms, measured by the Patient Health Questionnaire (PHQ-15), among individuals with or without a confirmed COVID-19 diagnosis, by acute illness severity, and by time since diagnosis. We additionally assessed the change in symptoms in a subset of Swedish adults with repeated measures, before and after COVID-19 diagnosis., Findings: During up to 27 months of follow-up, 34.5% participants (22,382/64,880) were diagnosed with COVID-19. Individuals who were diagnosed with COVID-19, compared to those not diagnosed, had an overall 37% higher prevalence of severe physical symptom burden (PHQ-15 score ≥15, adjusted prevalence ratio [PR] 1.37 [95% confidence interval [CI] 1.23-1.52]). The prevalence was associated with acute COVID-19 severity: individuals bedridden for seven days or longer presented with the highest prevalence (PR 2.25 [1.85-2.74]), while individuals never bedridden presented with similar prevalence as individuals not diagnosed with COVID-19 (PR 0.92 [0.68-1.24]). The prevalence was statistically significantly elevated among individuals diagnosed with COVID-19 for eight of the fifteen measured symptoms: shortness of breath, chest pain, dizziness, heart racing, headaches, low energy/fatigue, trouble sleeping, and back pain. The analysis of repeated measurements rendered similar results as the main analysis., Interpretation: These data suggest an elevated prevalence of some, but not all, physical symptoms during up to more than 2 years after diagnosis of COVID-19, particularly among individuals suffering a severe acute illness, highlighting the importance of continued monitoring and alleviation of these targeted core symptoms., Funding: This work was mainly supported by grants from NordForsk (COVIDMENT, grant number 105668 and 138929) and Horizon 2020 (CoMorMent, 847776). See Acknowledgements for further details on funding., Competing Interests: OAA receives support from the NordForsk (grant number 105668 COVIDMENT) and the European Union’s Horizon 2020 Research and Innovation Programme (Grant 847776; CoMorMent). OAA declares receiving grants or contracts from NIH NIMN Award (R01MH123724-01, 1R01MH124839, 1R01MH129742, 1R01MH129858-01A1), Research Council of Norway (RCN grants 223273, 296030, 300309, 324252), the South-East Norway Health Authority (grant 2017-112, 2022-073), European Union’s Horizon 2020 Research and Innovation Programme (Grant 964874 REALMENT), EEA-RO-NO-2018-0535, and KG Jebsen Stiftelsen (grants SKGJ-MED-008 and SKGJ-MED-021). OAA receives consulting fees from Biogen, Cortechs.ai and Milken. OAA gets Speaker’s honorarium from Janssen, Lundbeck and Sunovion, and has a patent on Intranasal Administration (US20160310683 A1). OAA participated in advisory board as National PI for JANSSEN trial depression, MAPS trial PTSD and BI trial schizophrenia. OAA declares having stock at Cortechs.ai. RP receives grant of Excellence, Icelandic Research Fund. RP declares to be the vice president at UEMS Section of Internal Medicine, a board member of the Icelandic Society of Internal Medicine, and is the president of the Icelandic Transplantation Society. EF received a payment for keynote lecture from Astra Zeneca. SUJ is a leader in Metacognitive Therapy Institute Norwegian Branch. FF receives support from the NordForsk (grant number 105668 and 138929 COVIDMENT) and the Horizon 2020 (Grant 847776; CoMorMent). UAV receives support from the NordForsk (grant number 105668 and 138929 COVIDMENT) and the Horizon 2020 (Grant 847776; CoMorMent). AL declares to receive Fredrik and Ingrid Thuring Foundation. OBVP receives Independent Research Fund Denmark (0214-00127B). QS declares receiving support from the Outstanding Clinical Discipline Project of Shanghai Pudong (Grant No.: PWYgy2021-02) and the Fundamental Research Funds for the Central Universities. PFS declares receiving funding from the Swedish Research Council (Vetenskapsrådet, award D0886501). PFS also receives consulting fees, participating on a data safety monitoring board or advisory board, and holds stock or stock options, from Neumora Therapeutics. All other authors declare no competing interests., (© 2023 The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
46. Unravelling the link between sleep and mental health during the COVID-19 pandemic.
- Author
-
González-Hijón J, Kähler AK, Frans EM, Valdimarsdóttir UA, Sullivan PF, Fang F, and Lovik A
- Subjects
- Humans, Pandemics, Sleep, Life Style, Depression, Anxiety, Mental Health, COVID-19 epidemiology
- Abstract
The emergence of COVID-19 brought unparalleled changes in people's lifestyle, including sleep. We aimed to assess the bidirectional association between sleep quality and mental health and describe how sleep and mental health were affected in Sweden during the COVID-19 pandemic (between June 2020 and September 2021). Data were obtained from the Omtanke2020 study. Participants who completed the baseline survey and each of the 8 monthly follow-up surveys were included (N = 9035). We described the distribution of sleep and mental health in the different Swedish regions using maps and over the study period with longitudinal graphs adjusting for sex, age, recruitment type (self-recruitment or invitation), and COVID-19 status. The inner relationships between mental health, sleep and Covid infection were described through relative importance networks. Finally, we modelled how mental health affects sleep and vice versa using generalized estimating equations with different adjustments. Seasonal and north-south regional variations were found in sleep and mental health outcomes at baseline and attenuated over time. The seasonal variation of sleep and mental health correlated moderately with the incidence rate of COVID-19 in the sample. Networks indicate that the relationship between COVID-19 incidence and mental health varies over time. We observed a bidirectional relationship between sleep quality and quantity at baseline and mental health at follow-up and vice versa. Sleep quality and quantity at baseline was associated with adverse symptom trajectories of mental health at follow-up, and vice versa, during the COVID-19 pandemic. There was also a weak relationship between COVID-19 incidence, sleep, and mental health., (© 2023 The Authors. Stress and Health published by John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
47. Shared familial risk factors between autism spectrum disorder and obesity - a register-based familial coaggregation cohort study.
- Author
-
Ahlberg R, Garcia-Argibay M, Hirvikoski T, Boman M, Chen Q, Taylor MJ, Frans E, Bölte S, and Larsson H
- Subjects
- Cohort Studies, Female, Genetic Predisposition to Disease, Humans, Male, Obesity epidemiology, Obesity genetics, Registries, Risk Factors, Sweden epidemiology, Autism Spectrum Disorder etiology, Autism Spectrum Disorder genetics, Intellectual Disability complications
- Abstract
Background: Meta-analyses suggest an association between autism spectrum disorder (ASD) and obesity, but the factors underlying this association remain unclear. This study investigated the association between ASD and obesity stratified on intellectual disability (ID). In addition, in order to gain insight into possible shared etiological factors, the potential role of shared familial liability was examined., Method: We studied a cohort of 3,141,696 individuals by linking several Swedish nationwide registers. We identified 35,461 individuals with ASD and 61,784 individuals with obesity. Logistic regression models were used to estimate the association between ASD and obesity separately by ID and sex and by adjusting for parental education, psychiatric comorbidity, and psychotropic medication. Potential shared familial etiologic factors were examined by comparing the risk of obesity in full siblings, maternal and paternal half-siblings, and full- and half-cousins of individuals with ASD to the risk of obesity in relatives of individuals without ASD., Results: Individuals with ASD + ID (OR = 3.76 [95% CI, 3.38-4.19]) and ASD-ID (OR = 3.40 [95% CI, 3.23-3.58]) had an increased risk for obesity compared with individuals without ASD. The associations remained statistically significant when adjusting for parental education, psychiatric comorbidity, and medication. Sex-stratified analyses indicated a higher relative risk for males compared with females, with statistically significant interaction effects for ASD-ID, but not for ASD+ID in the fully adjusted model. First-degree relatives of individuals with ASD+ID and ASD-ID had an increased risk of obesity compared with first-degree relatives of individuals without ASD. The obesity risk was similar in second-degree relatives of individuals with ASD+ID but was lower for and ASD-ID. Full cousins of individuals with ASD+ID had a higher risk compared with half-cousins of individuals with ASD+ID). A similar difference in the obesity risk between full cousins and half-cousins was observed for ASD-ID., Conclusions: Individuals with ASD and their relatives are at increased risk for obesity. The risk might be somewhat higher for males than females. This warrants further studies examining potential common pleiotropic genetic factors and shared family-wide environmental factors for ASD and obesity. Such research might aid in identifying specific risks and underlying mechanisms in common between ASD and obesity., (© 2021 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.)
- Published
- 2022
- Full Text
- View/download PDF
48. Older fathers' children have lower evolutionary fitness across four centuries and in four populations.
- Author
-
Arslan RC, Willführ KP, Frans EM, Verweij KJH, Bürkner PC, Myrskylä M, Voland E, Almqvist C, Zietsch BP, and Penke L
- Subjects
- Fathers, Humans, Male, Maternal Age, Sweden, Genetic Fitness, Paternal Age, Reproduction
- Abstract
Higher paternal age at offspring conception increases de novo genetic mutations. Based on evolutionary genetic theory we predicted older fathers' children, all else equal, would be less likely to survive and reproduce, i.e. have lower fitness. In sibling control studies, we find support for negative paternal age effects on offspring survival and reproductive success across four large populations with an aggregate N > 1.4 million. Three populations were pre-industrial (1670-1850) Western populations and showed negative paternal age effects on infant survival and offspring reproductive success. In twentieth-century Sweden, we found minuscule paternal age effects on survival, but found negative effects on reproductive success. Effects survived tests for key competing explanations, including maternal age and parental loss, but effects varied widely over different plausible model specifications and some competing explanations such as diminishing paternal investment and epigenetic mutations could not be tested. We can use our findings to aid in predicting the effect increasingly older parents in today's society will have on their children's survival and reproductive success. To the extent that we succeeded in isolating a mutation-driven effect of paternal age, our results can be understood to show that de novo mutations reduce offspring fitness across populations and time periods., (© 2017 The Authors.)
- Published
- 2017
- Full Text
- View/download PDF
49. Paternal age at childbearing and offspring psychiatric and academic morbidity.
- Author
-
D'Onofrio BM, Rickert ME, Frans E, Kuja-Halkola R, Almqvist C, Sjölander A, Larsson H, and Lichtenstein P
- Subjects
- Adolescent, Adult, Child, Cohort Studies, DNA Mutational Analysis, Female, Humans, Learning Disabilities genetics, Learning Disabilities psychology, Male, Mental Disorders genetics, Mental Disorders psychology, Middle Aged, Risk Factors, Statistics as Topic, Sweden, Young Adult, Educational Status, Learning Disabilities diagnosis, Learning Disabilities epidemiology, Mental Disorders diagnosis, Mental Disorders epidemiology, Paternal Age
- Abstract
Importance: Advancing paternal age is associated with increased genetic mutations during spermatogenesis, which research suggests may cause psychiatric morbidity in the offspring. The effects of advancing paternal age at childbearing on offspring morbidity remain unclear, however, because of inconsistent epidemiologic findings and the inability of previous studies to rigorously rule out confounding factors., Objective: To examine the associations between advancing paternal age at childbearing and numerous indexes of offspring morbidity., Design, Setting, and Participants: We performed a population-based cohort study of all individuals born in Sweden in 1973-2001 (N = 2,615,081), with subsets of the data used to predict childhood or adolescent morbidity. We estimated the risk of psychiatric and academic morbidity associated with advancing paternal age using several quasi-experimental designs, including the comparison of differentially exposed siblings, cousins, and first-born cousins., Exposure: Paternal age at childbearing., Main Outcomes and Measures: Psychiatric (autism, attention-deficit/hyperactivity disorder, psychosis, bipolar disorder, suicide attempt, and substance use problem) and academic (failing grades and low educational attainment) morbidity., Results: In the study population, advancing paternal age was associated with increased risk of some psychiatric disorders (eg, autism, psychosis, and bipolar disorders) but decreased risk of the other indexes of morbidity. In contrast, the sibling-comparison analyses indicated that advancing paternal age had a dose-response relationship with every index of morbidity, with the magnitude of the associations being as large or larger than the estimates in the entire population. Compared with offspring born to fathers 20 to 24 years old, offspring of fathers 45 years and older were at heightened risk of autism (hazard ratio [HR] = 3.45; 95% CI, 1.62-7.33), attention-deficit/hyperactivity disorder (HR = 13.13; 95% CI, 6.85-25.16), psychosis (HR = 2.07; 95% CI, 1.35-3.20), bipolar disorder (HR = 24.70; 95% CI, 12.12-50.31), suicide attempts (HR = 2.72; 95% CI, 2.08-3.56), substance use problems (HR = 2.44; 95% CI, 1.98-2.99), failing a grade (odds ratio [OR] = 1.59; 95% CI, 1.37-1.85), and low educational attainment (OR = 1.70; 95% CI, 1.50-1.93) in within-sibling comparisons. Additional analyses using several quasi-experimental designs obtained commensurate results, further strengthening the internal and external validity of the findings., Conclusions and Relevance: Advancing paternal age is associated with increased risk of psychiatric and academic morbidity, with the magnitude of the risks being as large or larger than previous estimates. These findings are consistent with the hypothesis that new genetic mutations that occur during spermatogenesis are causally related to offspring morbidity.
- Published
- 2014
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.