3 results on '"Fransisco Vega"'
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2. ALK+ Anaplastic Large Cell Lymphoma (ALCL)-Derived Exosomes Carry ALK Signalling Proteins and Interact With Tumor Microenvironment
- Author
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Dimitrios Chioureas, Janina Beck, George Baltatzis, Pedro Fonseca, Nikolaos Tsesmetzis, Ioulia Vardaki, Fransisco Vega, Vasiliki Leventaki, Elias Drakos, George Rassidakis, and Theocharis Panaretakis
- Subjects
hemic and lymphatic diseases - Abstract
The oncogenic pathways activated by the NPM-ALK chimeric kinase of ALK+ anaplastic large cell lymphoma (ALCL) are well characterised, however, the potential interactions of ALK signalling with the microenvironment are not yet known. Here we report that ALK+ ALCL-derived exosomes contain critical components of ALK signalling as well as CD30 and that exosome uptake by lymphoid cells led to increased proliferation and expression of critical antiapoptotic proteins by the recipient cells. The bone marrow fibroblasts highly uptake ALK+ ALCL - derived exosomes and acquire cancer-associated fibroblast (CAF) phenotype. Moreover, exosome-mediated activation of stromal cells altered the cytokine profile of the microenvironment. These interactions may contribute to tumor aggressiveness and possibly resistance to treatment.
- Published
- 2020
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3. List of Contributors
- Author
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Jose M Acuin, Rodney D Adam, Tsiri Agbenyega, AM Shamsir Ahmed, Tahmeed Ahmed, S Asad Ali, Gregory M Anstead, George E Armah, Stephen J Aston, Ronald C Ballard, Elizabeth D Barnett, Imelda Bates, Charles W Beadling, Nicholas J Beeching, Michael L Bennish, Caryn Bern, Frank J Bia, Brian H Bird, Allyson K Bloom, Gerard Bodeker, Robert W Bradsher, Nynke van den Broek, Simon Brooker, John T Brooks, W Abdullah Brooks, Philippe Brouqui, Michael Brown, Fabrizio Bruschi, Donald AP Bundy, Danai Bunnag, Benjamin Caballero, Michael V Callahan, Aulasa J Camerlin, Grant L Campbell, Jonathan R Carapetis, Enitan D Carrol, Eric Caumes, Remi N Charrel, Anna M Checkley, Mala Chhabra, Tepirou Chher, Charlotte M Chiong, M Jobayer Chisti, David C Christiani, Bradley A Connor, Edward S Cooper, Philip J Cooper, R Richard Coughlin, John H Cross, Nigel N Cunliffe, Mark Danta, Nicholas PJ Day, Paron Dekumyoy, Nilanthi deSilva, Gregory Deye, Rebecca Dillingham, H Rogier van Doorn, Barbara Doudier, Michel Drancourt, Françoise Dromer, Michael Eddleston, Samer S El-Kamary, Jeremy Farrar, Wafaie Fawzi, Nicholas A Feasey, Vanessa Field, Marc Fischer, Susan Fisher-Hoch, Kevin Forsyth, LeAnne M Fox, Arthur M Friedlander, Gerson Galdos-Cardenas, Hector H Garcia, Lynne S Garcia, Anna-Maria Geretti, Achilleas Gikas, Robert H Gilman, Victor Javier Sanchez Gonzalez, Melita A Gordon, Richard A Gosselin, Stephen M Graham, Alison D Grant, James J Gray, John R Graybill, Bertrand Graz, Stephen Green, Jeffrey K Griffiths, Bruno Gryseels, Duane J Gubler, Rathi Guhadasan, Aron J Hall, Davidson Hamer, David Harley, Jason B Harris, Amy L Hartman, Oliver Hassall, Roderick J Hay, Chris F Heyns, David R Hill, Martin H Hobdell, Caroline M den Hoed, Meredith L Holtz, M Iqbal Hossain, Peter J Hotez, Eric R Houpt, Cynthia R Howard, Chien-Ching Hung, Munirul Islam, Elizabeth Joekes, Victoria Johnston, Sam Kampondeni, Gagandeep Kang, Powel Kazanjian, Jay S Keystone, Wasif Ali Khan, Arthur Y Kim, Christopher L King, Amy D Klion, Richard Knight, Peter James Krause, Sanjeev Krishna, Ernst J Kuipers, Angelle D LaBeaud, David G Lalloo, Xavier De Lamballerie, Saba Lambert, Regina C LaRocque, John Lawrenson, Myron M Levine, Daniel H Libraty, Diana NJ Lockwood, Kinke M Lommerse, Olivier Lortholary, Rogelio López-Vélez, Benjamin A Lopman, David Mabey, Alan J. Magill, Ciro Maguiña, Syed Faisal Mahmood, Kathryn Maitland, Hadi Manji, Barbara J Marston, Anu Mathew, Christine E Mathews, Max Maurin, Paola J Maurtua-Neumann, Philippe Mayaud, Bongani M Mayosi, Joseph B McCormick, Stephen McKew, Susan LF McLellan, Peter C McMinn, Joseph D Mega, Donald E Meier, Matthieu Million, Veena Mittal, Elizabeth M Molyneux, Susan P Montgomery, Pedro Morera, Pedro L Moro, William J Moss, K Darwin Murrell, Osamu Nakagomi, Toyoko Nakagomi, Neha Nanda, James P Nataro, Eileen E Navaro, Ronald C Neafie, Ricardo Negroni, Ann M Nelson, Paul N Newton, Robert Newton, Stuart T Nichol, Francesca F Norman, Marcio RT Nunes, Thomas B Nutman, Richard A Oberhelman, Edward C Oldfield, Eloy E Ordaya, Christopher D Paddock, Slobodan Paessler, Ilias C Papanikolaou, Georgios Pappas, Luc Paris, Philippe Parola, Christopher M Parry, Manish M Patel, Sharon J Peacock, Rosanna Peeling, Hans Persson, Philip J Peters, Jonathan J Phillips, Richard O Phillips, Farah Naz Qamar, Atif Rahman, Jamilla Rajab, Didier Raoult, Michael F Rein, Aurélié Renvoisé, Jean-Marc Reynes, Frank O Richards, John Richens, Anne W Rimoin, Robert Riviello, Ema G Rodrigues, Allan R Ronald, Benjamin M Rosenthal, David Rosmarin, Ernesto Ruiz-Tiben, Edward T Ryan, Debasish Saha, Arturo Saavedra, Peter M Schantz, Tony Schountz, Sandra K Schumacher, James J Sejvar, Aisha Sethi, Kwonjune J Seung, Om Prakash Sharma, Trueman W Sharp, Anuraj H Shankar, Sonya S Shin, David R Shlim, Nicholas J van Sickels, Freddy Sitas, Thomas L Snelling, Cristina Socolovschi, Tom Solomon, J Erin Staples, Robert C Stewart, August Stich, G Thomas Strickland, Kathryn N Suh, Andreas Suhrbier, Khuanchai Supparatpinyo, Catherine G Sutcliffe, Brett E Swierczewski, John L Tarpley, Hugh R Taylor, Terrie Taylor, Harry J Thomas, C Louise Thwaites, Guy E Thwaites, Tejpratap SP Tiwari, Phan Van Tu, Angus W Turner, Edouard Vannier, Pedro FC Vasconcelos, Fransisco Vega-López, Jorge J Velarde, Nicholas J Vietri, Govinda S Visvesvara, Keyur S Vyas, Katie Wakeham, Thomas J Walsh, Mark H Wansbrough-Jones, David A Warrell, Mary J Warrell, Haider J Warraich, George Watt, Yupaporn Wattanagoon, Dorn Watthanakulpanich, Scott C Weaver, Rachel B Webman, Paul J Weidle, Louis M Weiss, Nicholas J White, Christopher JM Whitty, Dana M Woodhall, Stephen G Wright, Ramnik J Xavier, Lihua Xiao, Hongjie Yu, and Anita KM Zaidi
- Published
- 2013
- Full Text
- View/download PDF
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