1. Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis.
- Author
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Lotte K Vogel, Mona Sæbø, Helle Høyer, Tine Iskov Kopp, Ulla Vogel, Sine Godiksen, Franz B Frenzel, Julian Hamfjord, Inger Marie Bowitz-Lothe, Egil Johnson, Elin H Kure, and Vibeke Andersen
- Subjects
Medicine ,Science - Abstract
Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation.PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort.PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P
- Published
- 2014
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