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1. Methods and participant characteristics in the Cancer Risk in Vegetarians Consortium: a cross-sectional analysis across 11 prospective studies

Author

Dunneram, Yashvee, Lee, Jia Yi, Watling, Cody Z., Fraser, Gary E., Miles, Fayth, Prabhakaran, Dorairaj, Shridhar, Krithiga, Kondal, Dimple, Mohan, Viswanathan, Ali, Mohammed K., Narayan, Kabayam M. Venkat, Tandon, Nikhil, Tong, Tammy Y. N., Chiu, Tina H. T., Lin, Ming-Nan, Lin, Chin-Lon, Yang, Hsin-Chou, Liang, Yu-Jen, Greenwood, Darren C., Du, Huaidong, Chen, Zhengming, Yu, Canqing, Kakkoura, Maria G., Reeves, Gillian K., Papier, Keren, Floud, Sarah, Sinha, Rashmi, Liao, Linda M., Loftfield, Erikka, Cade, Janet E., Key, Timothy J., and Perez-Cornago, Aurora

Published
2024
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5. Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S, Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E, de González, Amy Berrington, Buring, Julie E, Fraser, Gary E, Freedman, Neal D, Gapstur, Susan M, Gierach, Gretchen, Giles, Graham G, Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F, Lan, Qing, Larsson, Susanna C, Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M, Milne, Roger L, Monroe, Kristine R, Neuhouser, Marian L, O'Brien, Katie M, Petrick, Jessica L, Purdue, Mark P, Rohan, Thomas E, Sandin, Sven, Sandler, Dale P, Sawada, Norie, Shadyab, Aladdin H, Simon, Tracey G, Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-I, Zheng, Wei, McGlynn, Katherine A, Campbell, Peter T, and Koshiol, Jill

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Aging, Prevention, Clinical Research, Contraception/Reproduction, Digestive Diseases, Cancer, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Adult, Aged, Biliary Tract Neoplasms, Female, Follow-Up Studies, Global Health, Humans, Incidence, Middle Aged, Prospective Studies, Registries, Reproduction, Risk Assessment, Risk Factors, Sex Factors, Survival Rate, Time Factors, Young Adult, Reproductive factors, Parity, Biliary tract cancer, Gallbladder cancer, Public Health and Health Services, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsGallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a male predominance. However, the role of female reproductive factors in BTC etiology remains unclear.MethodsWe pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study.ResultsDuring 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic bile duct cancer (IHBDC), 450 of extrahepatic bile duct cancer (EHBDC), and 261 of ampulla of Vater cancer (AVC) occurred. High parity was associated with risk of GBC (HR ≥5 vs. 0 births 1.72; 95% CI 1.25-2.38). Age at menarche (HR per year increase 1.15; 95% CI 1.06-1.24) was associated with GBC risk in Asian women while reproductive years were associated with GBC risk (HR per 5 years 1.13; 95% CI 1.04-1.22) in non-Asian women. Later age at menarche was associated with IHBDC (HR 1.19; 95% CI 1.09-1.31) and EHBDC (HR 1.11; 95% CI 1.01-1.22) in Asian women only.ConclusionWe observed an increased risk of GBC with increasing parity. Among Asian women, older age at menarche was associated with increased risk for GBC, IHBDC, and EHBDC, while increasing reproductive years was associated with GBC in non-Asian women. These results suggest that sex hormones have distinct effects on cancers across the biliary tract that vary by geography.Lay summaryOur findings show that the risk of gallbladder cancer is increased among women who have given birth (especially women with 5 or more children). In women from Asian countries, later age at menarche increases the risk of gallbladder cancer, intrahepatic bile duct cancer and extrahepatic bile duct cancer. We did not see this same association in women from Western countries. Age at menopause was not associated with the risk of any biliary tract cancers.

Published
2020

8. Cancer risk in living kidney donors

Author

Engels, Eric A., Fraser, Gary E., Kasiske, Bertram L., Snyder, Jon J., Utt, Jason, Lynch, Charles F., Li, Jie, Pawlish, Karen S., Brown, Sandra, Yu, Kelly J., and Pfeiffer, Ruth M.

Published
2022
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18. Methods and participant characteristics in the Cancer Risk in Vegetarians Consortium: A cross-sectional analysis across 11 prospective studies

Author

Dunneram, Yashvee, primary, Lee, Jia Yi, additional, Watling, Cody Z., additional, Fraser, Gary E, additional, Miles, Fayth, additional, Prabhakaran, Dorairaj, additional, Shridhar, Krithiga, additional, Kondal, Dimple, additional, Mohan, Viswanathan, additional, Ali, Mohammed K., additional, Venkat Narayan, Kabayam M., additional, Tandon, Nikhil, additional, Tong, Tammy Y. N., additional, Chiu, Tina H.T., additional, Lin, Ming-Nan, additional, Lin, Chin-Lon, additional, Yang, Hsin-Chou, additional, Liang, Yu-Jen, additional, Greenwood, Darren C., additional, Du, Huaidong, additional, Chen, Zhengming, additional, Yu, Canqing, additional, Kakkoura, Maria G., additional, Reeves, Gillian K., additional, Papier, Keren, additional, Floud, Sarah, additional, Sinha, Rashmi, additional, Liao, Linda M., additional, Loftfield, Erikka, additional, Cade, Janet E., additional, Key, Timothy J., additional, and Perez-Cornago, Aurora, additional

Published
2024
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19. Association between class III obesity (BMI of 40-59 kg/m2) and mortality: a pooled analysis of 20 prospective studies.

Author

Kitahara, Cari M, Flint, Alan J, Berrington de Gonzalez, Amy, Bernstein, Leslie, Brotzman, Michelle, MacInnis, Robert J, Moore, Steven C, Robien, Kim, Rosenberg, Philip S, Singh, Pramil N, Weiderpass, Elisabete, Adami, Hans Olov, Anton-Culver, Hoda, Ballard-Barbash, Rachel, Buring, Julie E, Freedman, D Michal, Fraser, Gary E, Beane Freeman, Laura E, Gapstur, Susan M, Gaziano, John Michael, Giles, Graham G, Håkansson, Niclas, Hoppin, Jane A, Hu, Frank B, Koenig, Karen, Linet, Martha S, Park, Yikyung, Patel, Alpa V, Purdue, Mark P, Schairer, Catherine, Sesso, Howard D, Visvanathan, Kala, White, Emily, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Hartge, Patricia

Subjects
Humans, Obesity, Body Mass Index, Life Expectancy, Risk Factors, Prospective Studies, United States, Australia, Sweden, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundThe prevalence of class III obesity (body mass index [BMI]≥40 kg/m2) has increased dramatically in several countries and currently affects 6% of adults in the US, with uncertain impact on the risks of illness and death. Using data from a large pooled study, we evaluated the risk of death, overall and due to a wide range of causes, and years of life expectancy lost associated with class III obesity.Methods and findingsIn a pooled analysis of 20 prospective studies from the United States, Sweden, and Australia, we estimated sex- and age-adjusted total and cause-specific mortality rates (deaths per 100,000 persons per year) and multivariable-adjusted hazard ratios for adults, aged 19-83 y at baseline, classified as obese class III (BMI 40.0-59.9 kg/m2) compared with those classified as normal weight (BMI 18.5-24.9 kg/m2). Participants reporting ever smoking cigarettes or a history of chronic disease (heart disease, cancer, stroke, or emphysema) on baseline questionnaires were excluded. Among 9,564 class III obesity participants, mortality rates were 856.0 in men and 663.0 in women during the study period (1976-2009). Among 304,011 normal-weight participants, rates were 346.7 and 280.5 in men and women, respectively. Deaths from heart disease contributed largely to the excess rates in the class III obesity group (rate differences = 238.9 and 132.8 in men and women, respectively), followed by deaths from cancer (rate differences = 36.7 and 62.3 in men and women, respectively) and diabetes (rate differences = 51.2 and 29.2 in men and women, respectively). Within the class III obesity range, multivariable-adjusted hazard ratios for total deaths and deaths due to heart disease, cancer, diabetes, nephritis/nephrotic syndrome/nephrosis, chronic lower respiratory disease, and influenza/pneumonia increased with increasing BMI. Compared with normal-weight BMI, a BMI of 40-44.9, 45-49.9, 50-54.9, and 55-59.9 kg/m2 was associated with an estimated 6.5 (95% CI: 5.7-7.3), 8.9 (95% CI: 7.4-10.4), 9.8 (95% CI: 7.4-12.2), and 13.7 (95% CI: 10.5-16.9) y of life lost. A limitation was that BMI was mainly ascertained by self-report.ConclusionsClass III obesity is associated with substantially elevated rates of total mortality, with most of the excess deaths due to heart disease, cancer, and diabetes, and major reductions in life expectancy compared with normal weight. Please see later in the article for the Editors' Summary.

Published
2014

20. Association of tea and coffee consumption and biliary tract cancer risk: The Biliary Tract Cancers Pooling Project.

Author

Yu-Han Huang, Loftfield, Erikka, Argirion, Ilona, Adami, Hans-Olov, Albanes, Demetrius, Chan, Andrew T., Fedirko, Veronika, Fraser, Gary E., Freedman, Neal D., Giles, Graham G., Hartge, Patricia, Katzke, Verena, Knutsen, Synnove F., Lacey Jr, James, Liao, Linda M., Juhua Luo, Milne, Roger L., O'Brien, Katie M., Peters, Ulrike, and Poynter, Jenny N.

Published
2024
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32. Supplementary Table 1 from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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33. Data from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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34. Supplementary Table 2 from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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35. Supplementary Figure from Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S., primary, Van Dyke, Alison L., primary, Zhu, Bin, primary, Pfeiffer, Ruth M., primary, Petrick, Jessica L., primary, Adami, Hans-Olov, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Beane Freeman, Laura E., primary, Berrington de González, Amy, primary, Buring, Julie E., primary, Chan, Andrew T., primary, Chen, Yu, primary, Fraser, Gary E., primary, Freedman, Neal D., primary, Gao, Yu-Tang, primary, Gapstur, Susan M., primary, Gaziano, J. Michael, primary, Giles, Graham G., primary, Grant, Eric J., primary, Grodstein, Francine, primary, Hartge, Patricia, primary, Jenab, Mazda, primary, Kitahara, Cari M., primary, Knutsen, Synnove F., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lee, I-Min, primary, Liao, Linda M., primary, Luo, Juhua, primary, McGee, Emma E., primary, Milne, Roger L., primary, Monroe, Kristine R., primary, Neuhouser, Marian L., primary, O’Brien, Katie M., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Purdue, Mark P., primary, Robien, Kim, primary, Sandler, Dale P., primary, Sawada, Norie, primary, Schairer, Catherine, primary, Sesso, Howard D., primary, Simon, Tracey G., primary, Sinha, Rashmi, primary, Stolzenberg-Solomon, Rachael Z., primary, Tsugane, Shoichiro, primary, Wang, Renwei, primary, Weiderpass, Elisabete, primary, Weinstein, Stephanie J., primary, White, Emily, primary, Wolk, Alicja, primary, Yuan, Jian-Min, primary, Zeleniuch-Jacquotte, Anne, primary, Zhang, Xuehong, primary, McGlynn, Katherine A., primary, Campbell, Peter T., primary, and Koshiol, Jill, primary

Published
2023
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36. Data from Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S., primary, Van Dyke, Alison L., primary, Zhu, Bin, primary, Pfeiffer, Ruth M., primary, Petrick, Jessica L., primary, Adami, Hans-Olov, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Beane Freeman, Laura E., primary, Berrington de González, Amy, primary, Buring, Julie E., primary, Chan, Andrew T., primary, Chen, Yu, primary, Fraser, Gary E., primary, Freedman, Neal D., primary, Gao, Yu-Tang, primary, Gapstur, Susan M., primary, Gaziano, J. Michael, primary, Giles, Graham G., primary, Grant, Eric J., primary, Grodstein, Francine, primary, Hartge, Patricia, primary, Jenab, Mazda, primary, Kitahara, Cari M., primary, Knutsen, Synnove F., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lee, I-Min, primary, Liao, Linda M., primary, Luo, Juhua, primary, McGee, Emma E., primary, Milne, Roger L., primary, Monroe, Kristine R., primary, Neuhouser, Marian L., primary, O’Brien, Katie M., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Purdue, Mark P., primary, Robien, Kim, primary, Sandler, Dale P., primary, Sawada, Norie, primary, Schairer, Catherine, primary, Sesso, Howard D., primary, Simon, Tracey G., primary, Sinha, Rashmi, primary, Stolzenberg-Solomon, Rachael Z., primary, Tsugane, Shoichiro, primary, Wang, Renwei, primary, Weiderpass, Elisabete, primary, Weinstein, Stephanie J., primary, White, Emily, primary, Wolk, Alicja, primary, Yuan, Jian-Min, primary, Zeleniuch-Jacquotte, Anne, primary, Zhang, Xuehong, primary, McGlynn, Katherine A., primary, Campbell, Peter T., primary, and Koshiol, Jill, primary

Published
2023
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37. Supplementary Tables from Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S., primary, Van Dyke, Alison L., primary, Zhu, Bin, primary, Pfeiffer, Ruth M., primary, Petrick, Jessica L., primary, Adami, Hans-Olov, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Beane Freeman, Laura E., primary, Berrington de González, Amy, primary, Buring, Julie E., primary, Chan, Andrew T., primary, Chen, Yu, primary, Fraser, Gary E., primary, Freedman, Neal D., primary, Gao, Yu-Tang, primary, Gapstur, Susan M., primary, Gaziano, J. Michael, primary, Giles, Graham G., primary, Grant, Eric J., primary, Grodstein, Francine, primary, Hartge, Patricia, primary, Jenab, Mazda, primary, Kitahara, Cari M., primary, Knutsen, Synnove F., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lee, I-Min, primary, Liao, Linda M., primary, Luo, Juhua, primary, McGee, Emma E., primary, Milne, Roger L., primary, Monroe, Kristine R., primary, Neuhouser, Marian L., primary, O’Brien, Katie M., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Purdue, Mark P., primary, Robien, Kim, primary, Sandler, Dale P., primary, Sawada, Norie, primary, Schairer, Catherine, primary, Sesso, Howard D., primary, Simon, Tracey G., primary, Sinha, Rashmi, primary, Stolzenberg-Solomon, Rachael Z., primary, Tsugane, Shoichiro, primary, Wang, Renwei, primary, Weiderpass, Elisabete, primary, Weinstein, Stephanie J., primary, White, Emily, primary, Wolk, Alicja, primary, Yuan, Jian-Min, primary, Zeleniuch-Jacquotte, Anne, primary, Zhang, Xuehong, primary, McGlynn, Katherine A., primary, Campbell, Peter T., primary, and Koshiol, Jill, primary

Published
2023
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42. Left ventricular diastolic abnormalities in vegetarians compared with non-vegetarians.

Author

Varadarajan, Padmini, Pai, Ramdas G., Fraser, Gary E., Abramov, Dmitry, Jabo, Brice, Mashchak, Andrew, Herring, Patricia, Burton, Barbara, Sveen, Lars E., and Knutsen, Synnove F.

Subjects
LEFT heart ventricle, ECHOCARDIOGRAPHY, BIOMARKERS, HYPERTENSION, OBESITY, VEGETARIANISM, BODY weight, CROSS-sectional method, AGE distribution, DIET, DIABETES, RACE, REGRESSION analysis, BODY surface area, SEX distribution, PHYSICAL activity, T-test (Statistics), FACTOR analysis, CHI-squared test, DESCRIPTIVE statistics, RESEARCH funding, DIASTOLE (Cardiac cycle), HEART failure
Abstract

Vegetarians have less hypertension, diabetes mellitus and obesity, hence possibly lower risk of congestive heart failure (HF). We studied associations between vegetarian diets and echocardiographic markers of stage B HF. In a cross-sectional study, dietary pattern was ascertained by a validated FFQ. Echocardiograms were interpreted using standardised criteria. Participants were free-living subjects in Southern California who were older Adventist Health Study-2 cohort members. After exclusions, 133 subjects aged >60 years were enrolled. Their mean age was 72·7 (sd 8·7) years, 48·1 % were female, 32 % were African American and 71 % were vegetarian. Non-vegetarians had higher body weight (80·3 (sd 15·17) kg v. 71·3 (sd 16·2), P < 0·005), body surface area (1·92 (sd 0·24) m2 v. 1·81 (sd 0·22) m2, P = 0·01) and prevalence of hypertension (63 % v. 47 %, P = 0·10). Adjusting for age, sex, race and physical activity, it is found that vegetarians had greater echocardiographic mitral annular e' velocity (a measure of left ventricular (LV) relaxation) 7·44 v. 6·48 (non-vegetarian) cm/s (P = 0·011) and a yet greater contrast when vegans (7·66 cm/s, P = 0·011) were the group of interest. The ratio mid-to-late-diastolic mitral flow velocity (E/A) was also higher in vegans compared with non-vegetarians (1·02 and 0·84, respectively, P = 0·008). Mediation analyses suggested these associations may be partly related to higher blood pressures and BMI in the non-vegetarians. We conclude that vegetarians, especially vegans, appear to have better LV relaxation and fewer diastolic abnormalities than others. As dietary exposure is modifiable, one may speculate pending further investigation about the potential for reduction of stage B HF and later mortality. [ABSTRACT FROM AUTHOR]

Published
2023
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