21 results on '"Fraticelli, Silvia"'
Search Results
2. Analysis of female enrollment in clinical trials for alcohol and substance use disorders: Is it time for sex-informed pharmacotherapy?
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Montemitro, Chiara, primary, Cavallotto, Clara, additional, Giovannetti, Giulia, additional, Martino, Fabrizio, additional, Pasino, Arianna, additional, Vicinelli, Maria Chiara, additional, Fraticelli, Silvia, additional, Di Giannantonio, Massimo, additional, and Spagnolo, Primavera A., additional
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- 2022
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3. Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports
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Berardis, Domenico De, primary, Fornaro, Michele, additional, Ventriglio, Antonio, additional, Valchera, Alessandro, additional, Vellante, Federica, additional, Pettorruso, Mauro, additional, Martinotti, Giovanni, additional, Fraticelli, Silvia, additional, and Giannantonio, Massimo Di, additional
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- 2021
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4. Suicide and Genetic Biomarkers: Toward Personalized Tailored-treatment with Lithium and Clozapine
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De Berardis, Domenico, primary, Vellante, Federica, additional, Pettorruso, Mauro, additional, Lucidi, Lorenza, additional, Tambelli, Antonio, additional, Di Muzio, Ilenia, additional, Gianfelice, Giulia, additional, Ventriglio, Antonio, additional, Fornaro, Michele, additional, Serafini, Gianluca, additional, Pompili, Maurizio, additional, Perna, Giampaolo, additional, Fraticelli, Silvia, additional, Martinotti, Giovanni, additional, and di Giannantonio, Massimo, additional
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- 2021
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5. A Possible Next Covid-19 Pandemic: The Violence Against Women and Its Psychiatric Consequences
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De Berardis, Domenico, primary, Gianfelice, Giulia, additional, Fornaro, Michele, additional, Vellante, Federica, additional, Ventriglio, Antonio, additional, Marini, Gabriella, additional, Pettorruso, Mauro, additional, Martinotti, Giovanni, additional, Fraticelli, Silvia, additional, and Di Giannantonio, Massimo, additional
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- 2021
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6. Gut Microbiota and Bipolar Disorder: An Overview on a Novel Biomarker for Diagnosis and Treatment
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Lucidi, Lorenza, primary, Pettorruso, Mauro, additional, Vellante, Federica, additional, Di Carlo, Francesco, additional, Ceci, Franca, additional, Santovito, Maria Chiara, additional, Di Muzio, Ilenia, additional, Fornaro, Michele, additional, Ventriglio, Antonio, additional, Tomasetti, Carmine, additional, Valchera, Alessandro, additional, Gentile, Alessandro, additional, Kim, Yong-Ku, additional, Martinotti, Giovanni, additional, Fraticelli, Silvia, additional, Di Giannantonio, Massimo, additional, and De Berardis, Domenico, additional
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- 2021
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7. Religious Coping, Hopelessness, and Suicide Ideation in Subjects with First-Episode Major Depression: An Exploratory Study in the Real World Clinical Practice
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De Berardis, Domenico, primary, Olivieri, Luigi, additional, Rapini, Gabriella, additional, Serroni, Nicola, additional, Fornaro, Michele, additional, Valchera, Alessandro, additional, Carano, Alessandro, additional, Vellante, Federica, additional, Bustini, Massimiliano, additional, Serafini, Gianluca, additional, Pompili, Maurizio, additional, Ventriglio, Antonio, additional, Perna, Giampaolo, additional, Fraticelli, Silvia, additional, Martinotti, Giovanni, additional, and Di Giannantonio, Massimo, additional
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- 2020
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8. Overcoming the Use of Mechanical Restraints in Psychiatry: A New Challenge in the Everyday Clinical Practice at the Time of COVID-19
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De Berardis, Domenico, primary, Ventriglio, Antonio, additional, Fornaro, Michele, additional, Vellante, Federica, additional, Martinotti, Giovanni, additional, Fraticelli, Silvia, additional, and Di Giannantonio, Massimo, additional
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- 2020
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9. An Update on Glutamatergic System in Suicidal Depression and on the Role of Esketamine
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De Berardis, Domenico, primary, Tomasetti, Carmine, additional, Pompili, Maurizio, additional, Serafini, Gianluca, additional, Vellante, Federica, additional, Fornaro, Michele, additional, Valchera, Alessandro, additional, Perna, Giampaolo, additional, Volpe, Umberto, additional, Martinotti, Giovanni, additional, Fraticelli, Silvia, additional, Di Giannantonio, Massimo, additional, Kim, Yong-Ku, additional, and Orsolini, Laura, additional
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- 2020
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10. Understanding the Complex of Suicide in Depression: from Research to Clinics
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Orsolini, Laura, primary, Latini, Roberto, additional, Pompili, Maurizio, additional, Serafini, Gianluca, additional, Volpe, Umberto, additional, Vellante, Federica, additional, Fornaro, Michele, additional, Valchera, Alessandro, additional, Tomasetti, Carmine, additional, Fraticelli, Silvia, additional, Alessandrini, Marco, additional, La Rovere, Raffaella, additional, Trotta, Sabatino, additional, Martinotti, Giovanni, additional, Di Giannantonio, Massimo, additional, and De Berardis, Domenico, additional
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- 2020
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11. Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports.
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De Berardis, Domenico, Fornaro, Michele, Ventriglio, Antonio, Valchera, Alessandro, Vellante, Federica, Pettorruso, Mauro, Martinotti, Giovanni, Fraticelli, Silvia, and Di Giannantonio, Massimo
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MEDICAL personnel ,POST-traumatic stress disorder ,TRAZODONE ,COVID-19 ,COVID-19 treatment ,SELF-efficacy ,BROMOMETHANE - Abstract
COVID-19 represents a significant stress factor for all people worldwide due to several factors, including quarantine, lockdowns, fear of contagion, deaths, and other traumatic events. However, the healthcare workers (HCWs) have paid the higher price of this pandemic in terms of fatalities, contagions, and psychological well-being. Studies suggest that this particular population is at increased risk of developing a severe post-traumatic stress disorder (PTSD). The early diagnosis and timely treatment of PTSD in HCWs may restore well-being and significantly impact health services functioning, reducing burnout, days spent far from work, disrupted personal and team empowerment, and worse job performances. In the present article, we reported on two cases of HCWs directly involved in the treatment of COVID-19 patients who showed selective serotonin reuptake inhibitor-resistant PTSD, which was successfully treated with extended-release trazodone TRZ ContramidⓇ add-on. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Alexithymia, resilience, somatic sensations and their relationships with suicide ideation in drug naïve patients with first‐episode major depression: An exploratory study in the “real world” everyday clinical practice
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De Berardis, Domenico, primary, Fornaro, Michele, additional, Valchera, Alessandro, additional, Rapini, Gabriella, additional, Di Natale, Serena, additional, De Lauretis, Ida, additional, Serroni, Nicola, additional, Orsolini, Laura, additional, Tomasetti, Carmine, additional, Bustini, Massimiliano, additional, Carano, Alessandro, additional, Vellante, Federica, additional, Perna, Giampaolo, additional, Core, Laura, additional, Alessandrini, Marco, additional, Fraticelli, Silvia, additional, Martinotti, Giovanni, additional, and Di Giannantonio, Massimo, additional
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- 2019
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13. Alexithymia, resilience, somatic sensations and their relationships with suicide ideation in drug naïve patients with first‐episode major depression: An exploratory study in the "real world" everyday clinical practice.
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De Berardis, Domenico, Fornaro, Michele, Valchera, Alessandro, Rapini, Gabriella, Di Natale, Serena, De Lauretis, Ida, Serroni, Nicola, Orsolini, Laura, Tomasetti, Carmine, Bustini, Massimiliano, Carano, Alessandro, Vellante, Federica, Perna, Giampaolo, Core, Laura, Alessandrini, Marco, Fraticelli, Silvia, Martinotti, Giovanni, and Di Giannantonio, Massimo
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SOMATIC sensation ,MENTAL depression ,ALEXITHYMIA ,SUICIDE risk factors ,PSYCHOLOGICAL resilience ,SUICIDAL ideation - Abstract
Aim: The present study is aimed at revaluating alexithymia, somatic sensations, resilience and their relationships with suicide ideation in drug naïve adult outpatients suffering from first episode major depression (MD). Methods: Data of 103 adult outpatients (49 men, 56 women) with a diagnostic and statistical manual of mental disorders, 4th edition, text revision (DSM‐IV‐TR) diagnosis of MD were analysed. Alexithymia was measured using the 20‐item Toronto Alexithymia Scale (TAS‐20) and resilience with the 25 items Connor‐Davidson Resilience Scale (CD‐RISC) whereas depression was evaluated using the 17‐item Hamilton Depression Rating Scale, somatic sensations with the Body Sensations Questionnaire and suicide ideation with Scale of Suicide Ideation (SSI). Results: Gender comparisons between all demographic and clinical variables showed no significant differences in all variables. Subjects who were found positive for alexithymia showed higher scores on all clinical variables controlling for age, gender and duration of the current episode. In a linear regression model, lower scores on CD‐RISC and Difficulty in Identifying Feelings dimension of TAS‐20 were significantly predictive of higher scores on SSI. Conclusions: Alexithymia and low resilience were significant predictors of increased suicide ideation in a first MD episode. However, study limitations must be considered and future research needs are being discussed. [ABSTRACT FROM AUTHOR]
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- 2020
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14. The interplay among psychopathology, personal resources, context‐related factors and real‐life functioning in schizophrenia: stability in relationships after 4 years and differences in network structure between recovered and non‐recovered patients
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Galderisi, Silvana, Rucci, Paola, Mucci, Armida, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Aguglia, Eugenio, Amore, Mario, Bellomo, Antonello, Bozzatello, Paola, Bucci, Paola, Carpiniello, Bernardo, Collantoni, Enrico, Cuomo, Alessandro, Dell'Osso, Liliana, Di Fabio, Fabio, Giannantonio, Massimo, Gibertoni, Dino, Giordano, Giulia Maria, Marchesi, Carlo, Monteleone, Palmiero, Oldani, Lucio, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Catapano, Francesco, Piegari, Giuseppe, Aiello, Carmen, Brando, Francesco, Giuliani, Luigi, Pietrafesa, Daria, Papalino, Marco, Mercadante, Giovanni, Di Palo, Piergiuseppe, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Pinna, Federica, Olivieri, Benedetta, Manca, Daniela, Signorelli, Maria Salvina, Poli, Laura Fusar, De Berardis, Domenico, Fraticelli, Silvia, Corbo, Mariangela, Pallanti, Stefano, Altamura, Mario, Carnevale, Raffaella, Malerba, Stefania, Calcagno, Pietro, Zampogna, Domenico, Corso, Alessandro, Giusti, Laura, Salza, Anna, Ussorio, Donatella, Talevi, Dalila, Socci, Valentina, Pacitti, Francesca, Bartolomeis, Andrea, Gramaglia, Carla, Gambaro, Eleonora, Gattoni, Eleonora, Favaro, Angela, Tenconi, Elena, Meneguzzo, Paolo, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan, Carpita, Barbara, Girardi, Nicoletta, Frascarelli, Marianna, Buzzanca, Antonio, Brugnoli, Roberto, Comparelli, Anna, Corigliano, Valentina, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Corrivetti, Giulio, Cascino, Giammarco, Buono, Gianfranco, Bolognesi, Simone, Fagiolini, Andrea, Goracci, Arianna, Bellino, Silvio, Montemagni, Cristiana, and Brasso, Claudio
- Abstract
Improving real‐life functioning is the main goal of the most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, the interplay among illness‐related variables, personal resources, context‐related factors and real‐life functioning in a large sample of patients with schizophrenia. The same research network has now completed a 4‐year follow‐up of the original sample. In the present study, we used network analysis to test whether the pattern of relationships among all variables investigated at baseline was similar at follow‐up. In addition, we compared the network structure of patients who were classified as recovered at follow‐up versus those who did not recover. Six hundred eighteen subjects recruited at baseline could be assessed in the follow‐up study. The network structure did not change significantly from baseline to follow‐up, and the overall strength of the connections among variables increased slightly, but not significantly. Functional capacity and everyday life skills had a high betweenness and closeness in the network at follow‐up, as they had at baseline, while psychopathological variables remained more peripheral. The network structure and connectivity of non‐recovered patients were similar to those observed in the whole sample, but very different from those in recovered subjects, in which we found few connections only. These data strongly suggest that tightly coupled symptoms/dysfunctions tend to maintain each other's activation, contributing to poor outcome in schizophrenia. Early and integrated treatment plans, targeting variables with high centrality, might prevent the emergence of self‐reinforcing networks of symptoms and dysfunctions in people with schizophrenia.
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- 2020
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15. rTMS Reduces Psychopathological Burden and Cocaine Consumption in Treatment-Seeking Subjects With Cocaine Use Disorder: An Open Label, Feasibility Study.
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Pettorruso, Mauro, Martinotti, Giovanni, Santacroce, Rita, Montemitro, Chiara, Fanella, Fabrizio, di Giannantonio, Massimo, De Risio, Luisa, Petrucci, Ilaria, Tourjansky, Gaia, Capicotto, Patrizia, Neri, Francesca, Ruggiero, Gianluca, Cassiani, Barbara, Fraticelli, Silvia, and Moroni, Valentina
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COCAINE-induced disorders ,TRANSCRANIAL magnetic stimulation ,SUBSTANCE-induced disorders ,FEASIBILITY studies ,COCAINE ,DESIRE ,DRUG-seeking behavior - Abstract
Introduction: Cocaine use disorder (CUD) currently represents a notable public health concern, linked with significant disability, high chances of chronicity, and lack of effective pharmacological or psychological treatments. Repetitive transcranial magnetic stimulation (rTMS) is supposed to be a potential therapeutic option for addictive disorders. Aim of this study was to evaluate the feasibility of rTMS on (1) cocaine craving and consumption and (2) other comorbid psychiatric symptoms. Methods: Twenty treatment seeking CUD subjects underwent 2 weeks of intensive rTMS treatment (15Hz; 5 days/week, twice a day for a total of 20 stimulation sessions) of the left dorsolateral prefrontal cortex, followed by 2 weeks of maintenance treatment (15Hz, 1 day/week, twice a day). Sixteen patients completed the study. Patients were evaluated at baseline (T0), after 2 weeks of treatment (T1), and at the end of the study (T2; 4 weeks), with the following scales: Cocaine Selective Severity Assessment (CSSA), Zung Self-Rating Anxiety Scale, Beck Depression Inventory (BDI), Symptom Checklist-90 (SCL-90), and the Insomnia Severity Index. Results: After four weeks of rTMS treatment, 9 out of 16 subjects (56.25%) had a negative urinalysis test, with a significant conversion rate with respect to baseline (Z = −3.00; p = 0.003). Craving scores significantly improved only at T2 (p = 0.020). The overall psychopathological burden, as measured by the SCL-90 Global Severity Index (GSI), significantly decreased during the study period (Z = −2.689; p = 0.007), with a relevant improvement with regards to depressive symptoms, anhedonia, and anxiety. Subjects exhibiting lower baseline scores on the SCL-90 were more likely to be in the positive outcome group at the end of the study (Z = −3.334; p = 0.001). Discussion: Findings from this study are consistent with previous contributions on rTMS use in subjects with cocaine use disorder. We evidenced a specific action on some psychopathological areas and a consequent indirect effect in terms of relapse prevention and craving reduction. A double-blind, sham-controlled, neuro-navigated rTMS study design is needed, in order to confirm the potential benefits of this technique, opening new scenarios in substance use disorders treatment. [ABSTRACT FROM AUTHOR]
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- 2019
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16. An Update on Glutamatergic System in Suicidal Depression and on the Role of Esketamine
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Federica Vellante, Massimo Di Giannantonio, Domenico De Berardis, Yong Ku Kim, Silvia Fraticelli, Giampaolo Perna, Gianluca Serafini, Giovanni Martinotti, Umberto Volpe, Carmine Tomasetti, Michele Fornaro, Maurizio Pompili, Laura Orsolini, Alessandro Valchera, De Berardis, Domenico, Tomasetti, Carmine, Pompili, Maurizio, Serafini, Gianluca, Vellante, Federica, Fornaro, Michele, Valchera, Alessandro, Perna, Giampaolo, Volpe, Umberto, Martinotti, Giovanni, Fraticelli, Silvia, Di Giannantonio, Massimo, Kim, Yong-Ku, and Orsolini, Laura
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Suicide Prevention ,MDD ,Oncology ,medicine.medical_specialty ,Time Factors ,Databases, Factual ,ketamine ,Drug Compounding ,depression ,esketamine ,glutamate ,glutamatergic system ,suicide ,treatment-resistant depression ,Glutamic Acid ,Receptors, N-Methyl-D-Aspartate ,Synaptic Transmission ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Drug Discovery ,medicine ,Humans ,Suicidal ideation ,Administration, Intranasal ,Depression (differential diagnoses) ,Clinical Trials as Topic ,Depressive Disorder, Major ,United States Food and Drug Administration ,business.industry ,General Medicine ,medicine.disease ,Antidepressive Agents ,United States ,030227 psychiatry ,Clinical trial ,Esketamine ,Treatment Outcome ,Mood ,Major depressive disorder ,Antidepressant ,medicine.symptom ,business ,Treatment-resistant depression ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background: A research on mood disorder pathophysiology has hypothesized abnormalities in glutamatergic neurotransmission, by suggesting further investigation on glutamatergic N-methyl-Daspartate (NMDA) receptor modulators in treating Major Depressive Disorder (MDD). Esketamine (ESK), an NMDA receptor antagonist able to modulate glutamatergic neurotransmission has been recently developed as an intranasal formulation for treatment-resistant depression (TRD) and for rapid reduction of depressive symptomatology, including suicidal ideation in MDD patients at imminent risk for suicide. Objective: The present study aims at investigating recent clinical findings on research on the role of the glutamatergic system and ESK in treating suicidal depression in MDD and TRD. Methods: A systematic review was here carried out on PubMed/Medline, Scopus and the database on U.S. N.I.H. Clinical Trials (https://clinicaltrials.gov) and the European Medical Agency (EMA) (https://clinicaltrialsregister.eu) from inception until October 2019. Results: Intravenous infusion of ESK is reported to elicit rapid-acting and sustained antidepressant activity in refractory patients with MDD and TRD. In phase II studies, intranasal ESK demonstrated a rapid onset and a persistent efficacy in patients with TRD as well as in MDD patients at imminent risk for suicide. However, some data discrepancies have emerged in phase III studies. Conclusion: The U.S. Food and Drug Administration (FDA) granted fast track and Breakthrough Therapy Designation to Janssen Pharmaceuticals®, Inc. for intranasal ESK in 2013 for treatment-resistant depression (TRD) and in 2016 for the treatment of MDD with an imminent risk of suicide. However, further studies should be implemented to investigate the long-term efficacy and safety of intranasal ESK.
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- 2020
17. Understanding the Complex of Suicide in Depression: from Research to Clinics
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Federica Vellante, Domenico De Berardis, Roberto Latini, Silvia Fraticelli, Alessandro Valchera, Sabatino Trotta, Umberto Volpe, Michele Fornaro, Carmine Tomasetti, Maurizio Pompili, Massimo Di Giannantonio, Laura Orsolini, Raffaella La Rovere, Gianluca Serafini, Giovanni Martinotti, Marco Alessandrini, Orsolini, Laura, Latini, Roberto, Pompili, Maurizio, Serafini, Gianluca, Volpe, Umberto, Vellante, Federica, Fornaro, Michele, Valchera, Alessandro, Tomasetti, Carmine, Fraticelli, Silvia, Alessandrini, Marco, La Rovere, Raffaella, Trotta, Sabatino, Martinotti, Giovanni, Di Giannantonio, Massimo, and De Berardis, Domenico
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Suicidal risk ,medicine.medical_specialty ,Population ,MEDLINE ,Psychological intervention ,Review Article ,Major depressive disorder ,Scientific evidence ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Psychiatry ,education ,Biological Psychiatry ,Depression (differential diagnoses) ,education.field_of_study ,Depression ,business.industry ,Stressor ,medicine.disease ,030227 psychiatry ,Assessment of suicide risk ,Suicide ,Psychiatry and Mental health ,business ,030217 neurology & neurosurgery - Abstract
Objective Amongst psychiatric disorders, major depressive disorder (MDD) is the most prevalent, by affecting approximately 15–17% of the population and showing a high suicide risk rate equivalent to around 15%. The present comprehensive overview aims at evaluating main research studies in the field of MDD at suicide risk, by proposing as well as a schematic suicide risk stratification and useful flow-chart for planning suicide preventive and therapeutic interventions for clinicians.Methods A broad and comprehensive overview has been here conducted by using PubMed/Medline, combining the search strategy of free text terms and exploded MESH headings for the topics of ‘Major Depressive Disorder’ and ‘Suicide’ as following: ((suicide [Title/Abstract]) AND (major depressive disorder [Title/Abstract])). All articles published in English through May 31, 2019 were summarized in a comprehensive way.Results Despite possible pathophysiological factors which may explain the complexity of suicide in MDD, scientific evidence supposed the synergic role of genetics, exogenous and endogenous stressors (i.e., interpersonal, professional, financial, as well as psychiatric disorders), epigenetic, the hypothalamic-pituitary-adrenal stress-response system, the involvement of the monoaminergic neurotransmitter systems, particularly the serotonergic ones, the lipid profile, neuro-immunological biomarkers, the Brain-derived neurotrophic factor and other neuromodulators.Conclusion The present overview reported that suicide is a highly complex and multifaceted phenomenon in which a large plethora of mechanisms could be variable implicated, particularly amongst MDD subjects. Beyond these consideration, modern psychiatry needs a better interpretation of suicide risk with a more careful assessment of suicide risk stratification and planning of clinical and treatment interventions.
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- 2020
18. Religious Coping, Hopelessness, and Suicide Ideation in Subjects with First-Episode Major Depression: An Exploratory Study in the Real World Clinical Practice
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Federica Vellante, Nicola Serroni, Domenico De Berardis, Luigi Olivieri, Gabriella Rapini, Maurizio Pompili, Massimiliano Bustini, Massimo Di Giannantonio, Gianluca Serafini, Antonio Ventriglio, Michele Fornaro, Alessandro Carano, Silvia Fraticelli, Giampaolo Perna, Alessandro Valchera, Giovanni Martinotti, RS: MHeNs - R2 - Mental Health, De Berardis, Domenico, Olivieri, Luigi, Rapini, Gabriella, Serroni, Nicola, Fornaro, Michele, Valchera, Alessandro, Carano, Alessandro, Vellante, Federica, Bustini, Massimiliano, Serafini, Gianluca, Pompili, Maurizio, Ventriglio, Antonio, Perna, Giampaolo, Fraticelli, Silvia, Martinotti, Giovanni, and Di Giannantonio, Massimo
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life ,Coping (psychology) ,STRESS ,CROATIAN WAR VETERANS ,Protective factor ,Exploratory research ,INTRINSIC RELIGIOSITY ,lcsh:RC321-571 ,scale ,Religiosity ,03 medical and health sciences ,0302 clinical medicine ,religious coping ,prevention ,high-risk ,Rating scale ,mental disorders ,hopelessness ,medicine ,resilience ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,First episode ,Communication ,General Neuroscience ,association ,social support ,medicine.disease ,religiosity ,030227 psychiatry ,hopelessne ,mental-health ,suicide ideation ,depression ,Beck Hopelessness Scale ,Major depressive disorder ,Psychology ,Depression ,Hopelessness ,Prevention ,Religious coping ,Suicide ideation ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Background. This study aimed to evaluate the potential relationships between religious coping, hopelessness, and suicide ideation in adult outpatients with the first episode of major depressive disorder (MDD). Methods. Ninety-four adult outpatients with MDD were assessed through the Hamilton Depression Rating Scale (HAM-D), the Beck Hopelessness Scale (BHS), and the Scale of Suicide Ideation (SSI). Religious coping was assessed with the Italian version of the Brief RCOPE scale, consisting of seven positive coping items (PosCop) and seven negative coping items (NegCop). Results. The results showed that the Brief RCOPE PosCop scale exhibited a strong inverse correlation with HAM-D, BHS, and SSI, whereas HAM-D and BHS were positively correlated with SSI. Brief RCOPE NegCop scores were positively correlated only with SSI. Regression analysis with SSI as the dependent variable showed that higher Brief RCOPE PosCop scores were associated with lower suicide ideation, whereas higher HAM-D and BHS scores were associated with higher suicide ideation. Conclusion. Positive religious coping may be a protective factor against the development of suicide ideation, perhaps counteracting the severity of depressive symptoms and hopelessness. The evaluation of religious coping should be performed in all subjects with MDD in everyday clinical practice. However, this study was preliminary, and limitations must be considered.
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- 2020
19. Overcoming the Use of Mechanical Restraints in Psychiatry: A New Challenge in the Everyday Clinical Practice at the Time of COVID-19
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Domenico De Berardis, Michele Fornaro, Massimo Di Giannantonio, Antonio Ventriglio, Silvia Fraticelli, Giovanni Martinotti, Federica Vellante, De Berardis, Domenico, Ventriglio, Antonio, Fornaro, Michele, Vellante, Federica, Martinotti, Giovanni, Fraticelli, Silvia, and Di Giannantonio, Massimo
- Subjects
2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,lcsh:R ,Psychological intervention ,MEDLINE ,lcsh:Medicine ,General Medicine ,Mental health ,030227 psychiatry ,Clinical Practice ,03 medical and health sciences ,Editorial ,n/a ,0302 clinical medicine ,Family medicine ,medicine ,030212 general & internal medicine ,business - Abstract
Restraining interventions, which comprise physical (PR) and mechanical restraint (MR), have a long history in mental health services [...]
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- 2020
20. Gender differences in attention deficit hyperactivity disorder: an update of the current evidence.
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Fraticelli S, Caratelli G, De Berardis D, Ducci G, Pettorruso M, Martinotti G, Di Cesare G, and di Giannantonio M
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- Comorbidity, Female, Humans, Male, Sex Factors, Attention Deficit Disorder with Hyperactivity diagnosis, Attention Deficit Disorder with Hyperactivity drug therapy, Attention Deficit Disorder with Hyperactivity epidemiology
- Abstract
The attention deficit hyperactivity disorder (ADHD) in women has recently received considerable attention, as research has shown an underestimation of the disorder in females, due to a difference in presentation compared to males: females have a higher risk of having ADHD, without those "disruptive" symptoms that determine the request for help. The purpose of the present narrative review is to identify the neglected clinical problems in the diagnostic and therapeutic intervention of women with ADHD and to analyze the associated comorbid problems. The conducted PubMed search and the relevant literature review on the topic show that the impairment of ADHD in women is underestimated due to the different ways the phenomenon manifests compared to traditional male's symptoms. This underestimation consequently leads to an inadequate treatment and has negative repercussions on the social context in which women are involved in.
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- 2022
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21. The effect of paliperidone palmitate long-acting injectable (PP-LAI) on "non-core" symptoms of schizophrenia: a retrospective, collaborative, multicenter study in the "real world" everyday clinical practice.
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De Berardis D, Vellante F, Olivieri L, Rapini G, De Lauretis I, Orsolini L, Valchera A, Carano A, Bustini M, De Persis S, Trotta S, Fornaro M, Ventriglio A, Martiadis V, Simione L, Pompili M, Serafini G, Di Nicola M, Alessandrini M, Martinotti G, Fraticelli S, and di Giannantonio M
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- Delayed-Action Preparations therapeutic use, Humans, Paliperidone Palmitate therapeutic use, Quality of Life, Retrospective Studies, Risperidone therapeutic use, Antipsychotic Agents adverse effects, Schizophrenia drug therapy
- Abstract
Background: Schizophrenia is frequently complicated by the occurrence of depressive symptoms, anhedonia, obsessions and compulsions, suicidal ideation, and substance abuse, that causes exacerbations and remissions and, in several cases, sustained morbidity and disability., Aim: The present study aimed to evaluate the effect of paliperidone palmitate once-monthly long-acting injection (PP-LAI) mainly on "non-core" symptoms in persons with recent diagnosis schizophrenia, during a follow-up period of almost 12 months (T1) in the context of the "real world" everyday clinical practice., Results: Concerning core symptoms of schizophrenia, PP-LAI was effective in reducing all symptoms at T1 as measured by Positive and Negative Syndrome Scale (PANSS), including depressive symptoms, and increased the functioning. Moreover, concerning the non-core symptoms of schizophrenia, PP-LAI treatment was effective in reducing scores of anhedonia, suicidal ideation and obsessive-compulsive symptoms at T1. However, the levels of alexithymia remained relatively stable, even if reduced., Discussion: The present retrospective, multicenter, non-sponsored, collaborative study showed that early PP-LAI treatment was effective in improving almost all the core dimensions and "non-core" symptoms of schizophrenia, and this may have positive repercussions on both functioning and quality of life., Conclusions: PP-LAI treatment should be offered earlier as possible and was effective on "non-core" symptoms of schizophrenia at follow-up, but had a little effect on alexithymia. However, study' limitations must be considered and future researches are needed to confirm these interesting findings.
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- 2021
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