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31 results on '"Frayo, Shani L."'

1. Data from Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers

Author

Green, Damian J., primary, Frayo, Shani L., primary, Lin, Yukang, primary, Hamlin, Donald K., primary, Fisher, Darrell R., primary, Frost, Sofia H.L., primary, Kenoyer, Aimee L., primary, Hylarides, Mark D., primary, Gopal, Ajay K., primary, Gooley, Theodore A., primary, Orozco, Johnnie J., primary, Till, Brian G., primary, O'Steen, Shyril, primary, Orcutt, Kelly D., primary, Wilbur, D. Scott, primary, Wittrup, K. Dane, primary, and Press, Oliver W., primary

Published
2023
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2. Data from A Preclinical Model of CD38-Pretargeted Radioimmunotherapy for Plasma Cell Malignancies

Author

Green, Damian J., primary, Orgun, Nural N., primary, Jones, Jon C., primary, Hylarides, Mark D., primary, Pagel, John M., primary, Hamlin, Donald K., primary, Wilbur, D.S., primary, Lin, Yukang, primary, Fisher, Darrell R., primary, Kenoyer, Aimee L., primary, Frayo, Shani L., primary, Gopal, Ajay K., primary, Orozco, Johnnie J., primary, Gooley, Theodore A., primary, Wood, Brent L., primary, Bensinger, William I., primary, and Press, Oliver W., primary

Published
2023
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3. Supplementary Figures 1 and 2 and Supplementary Methods from A Preclinical Model of CD38-Pretargeted Radioimmunotherapy for Plasma Cell Malignancies

Author

Green, Damian J., primary, Orgun, Nural N., primary, Jones, Jon C., primary, Hylarides, Mark D., primary, Pagel, John M., primary, Hamlin, Donald K., primary, Wilbur, D.S., primary, Lin, Yukang, primary, Fisher, Darrell R., primary, Kenoyer, Aimee L., primary, Frayo, Shani L., primary, Gopal, Ajay K., primary, Orozco, Johnnie J., primary, Gooley, Theodore A., primary, Wood, Brent L., primary, Bensinger, William I., primary, and Press, Oliver W., primary

Published
2023
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4. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

Author

Green, Damian J., Shadman, Mazyar, Jones, Jon C., Frayo, Shani L., Kenoyer, Aimee L., Hylarides, Mark D., Hamlin, Donald K., Wilbur, D. Scott, Balkan, Ethan R., Lin, Yukang, Miller, Brian W., Frost, Sofia.H.L., Gopal, Ajay K., Orozco, Johnnie J., Gooley, Theodore A., Laird, Kelly L., Till, Brian G., Bäck, Tom, Sandmaier, Brenda M., Pagel, John M., and Press, Oliver W.

Published
2015
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7. Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers

Author

Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Department of Biological Engineering, Green, Damian J., Frayo, Shani L., Lin, Yukang, Hamlin, Donald K., Fisher, Darrell R., Frost, Sofia H.L., Kenoyer, Aimee L., Hylarides, Mark D., Gopal, Ajay K., Gooley, Theodore A., Orozco, Johnnie J., Till, Brian G., O'Steen, Shyril, Orcutt, Kelly Davis, Wilbur, D. Scott, Wittrup, Karl Dane, Press, Oliver W., Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Department of Biological Engineering, Green, Damian J., Frayo, Shani L., Lin, Yukang, Hamlin, Donald K., Fisher, Darrell R., Frost, Sofia H.L., Kenoyer, Aimee L., Hylarides, Mark D., Gopal, Ajay K., Gooley, Theodore A., Orozco, Johnnie J., Till, Brian G., O'Steen, Shyril, Orcutt, Kelly Davis, Wilbur, D. Scott, Wittrup, Karl Dane, and Press, Oliver W.

Abstract

Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems, but SA immunogenicity and interference by endogenous biotin may complicate clinical translation of this approach. In this study, we engineered a bispecific fusion protein (FP) that evades the limitations imposed by this system. Briefly, one arm of the FP was an anti-human CD20 antibody (2H7), with the other arm of the FP an anti-chelated radiometal trap for a radiolabeled ligand (yttrium[Y]-DOTA) captured by a very high-affinity anti-Y-DOTA scFv antibody (C825). Head-to-head biodistribution experiments comparing SA-biotin and bispecific FP (2H7-Fc-C825) PRIT in murine subjects bearing human lymphoma xenografts demonstrated nearly identical tumor targeting by each modality at 24 hours. However, residual radioactivity in the blood and normal organs was consistently higher following administration of 1F5-SA compared with 2H7-Fc-C825. Consequently, tumor-to-normal tissue ratios of distribution were superior for 2H7-Fc-C825 (P < 0.0001). Therapy studies in subjects bearing either Ramos or Granta subcutaneous lymphomas demonstrated that 2H7-Fc-C825 PRIT is highly effective and significantly less myelosuppressive than 1F5-SA (P < 0.0001). All animals receiving optimal doses of 2H7-Fc-C825 followed by 90Y-DOTA were cured by 150 days, whereas the growth of tumors in control animals progressed rapidly with complete morbidity by 25 days. In addition to demonstrating reduced risk of immunogenicity and an absence of endogenous biotin interference, our findings offer a preclinical proof of concept for the preferred use of bispecific PRIT in future clinical trials, due to a slightly superior biodistribution profile, less myelosuppression, and superior efficacy.

Published
2020

9. Alpha imaging confirmed efficient targeting of CD45-positive cells after astatine-211 (211At)-radioimmunotherapy for hematopoietic cell transplantation

Author

Frost, Sofia H.L., Miller, Brian W., Bäck, Tom A., Santos, Erlinda B., Hamlin, Donald K., Knoblaugh, Sue E., Frayo, Shani L., Kenoyer, Aimee L., Storb, Rainer, Press, Oliver W., Wilbur, D. Scott, Pagel, John M., and Sandmaier, Brenda M.

Subjects
Biopsy, T-Lymphocytes, Hematopoietic Stem Cell Transplantation, Ascites, Radioimmunotherapy, Alpha Particles, Immunohistochemistry, Article, Dogs, Drug Delivery Systems, Bone Marrow, Animals, Leukocyte Common Antigens, Tissue Distribution, Lymph Nodes, Radiopharmaceuticals, Radiometry, Radionuclide Imaging, Astatine, Spleen
Abstract

α-radioimmunotherapy targeting CD45 may substitute for total-body irradiation in hematopoietic cell transplantation (HCT) preparative regimens for lymphoma. Our goal was to optimize the anti-CD45 monoclonal antibody (mAb; CA12.10C12) protein dose for (211)At-radioimmunotherapy, extending the analysis to include intraorgan (211)At activity distribution and α-imaging-based small-scale dosimetry, along with immunohistochemical staining.Eight normal dogs were injected with either a 0.75 (n = 5) or 1.00 (n = 3) mg/kg dose of (211)At-B10-CA12.10C12 (11.5-27.6 MBq/kg). Two were euthanized and necropsied 19-22 h after injection, and 6 received autologous HCT 3 d after (211)At-radioimmunotherapy, after lymph node and bone marrow biopsies at 2-4 and/or 19 h after injection. Blood was sampled to study toxicity and clearance; CD45 targeting was evaluated by flow cytometry. (211)At localization and small-scale dosimetry were assessed using two α-imaging systems: an α-camera and an ionizing-radiation quantum imaging detector (iQID) camera.(211)At uptake was highest in the spleen (0.31-0.61% injected activity [%IA]/g), lymph nodes (0.02-0.16 %IA/g), liver (0.11-0.12 %IA/g), and marrow (0.06-0.08 %IA/g). Lymphocytes in blood and marrow were efficiently targeted using either mAb dose. Lymph nodes remained unsaturated but displayed targeted (211)At localization in T lymphocyte-rich areas. Absorbed doses to blood, marrow, and lymph nodes were estimated at 3.1, 2.4, and 3.4 Gy/166 MBq, respectively. All transplanted dogs experienced transient hepatic toxicity. Liver enzyme levels were temporarily elevated in 5 of 6 dogs; one treated with 1.00 mg mAb/kg developed ascites and was euthanized 136 d after HCT.(211)At-anti-CD45 radioimmunotherapy with 0.75 mg mAb/kg efficiently targeted blood and marrow without severe toxicity. Dosimetry calculations and observed radiation-induced effects indicated that sufficient (211)At-B10-CA12.10C12 localization was achieved for efficient conditioning for HCT.

Published
2015

11. Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers

Author

Green, Damian J., primary, Frayo, Shani L., additional, Lin, Yukang, additional, Hamlin, Donald K., additional, Fisher, Darrell R., additional, Frost, Sofia H.L., additional, Kenoyer, Aimee L., additional, Hylarides, Mark D., additional, Gopal, Ajay K., additional, Gooley, Theodore A., additional, Orozco, Johnnie J., additional, Till, Brian G., additional, O'Steen, Shyril, additional, Orcutt, Kelly D., additional, Wilbur, D. Scott, additional, Wittrup, K. Dane, additional, and Press, Oliver W., additional

Published
2016
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12. Results of a Phase I-II Study of Fenretinide and Rituximab for Patients with B-Cell Lymphomas

Author

Cowan, Andrew J., primary, Stevenson, Philip, additional, Gooley, Ted A., additional, Frayo, Shani L., additional, Oliveira, George R., additional, Smith, Stephen D., additional, Green, Damian J., additional, Roden, Jennifer E., additional, Pagel, John M., additional, Wood, Brent L, additional, Press, Oliver W, additional, and Gopal, Ajay K., additional

Published
2015
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13. A Novel Bispecific CD38 Antibody Eradicates Multiple Myeloma in a Mouse Model Following Yttrium-90-DOTA Capture

Author

Green, Damian J, primary, Jones, Jon C, additional, Lin, Yukang, additional, Frayo, Shani L., additional, Kenoyer, Aimee L, additional, O'Steen, Shyril, additional, Peters, Arianna, additional, Frost, Sofia HL, additional, Orozco, Johnnie J., additional, Gopal, Ajay K, additional, Hylarides, Mark D, additional, Fisher, Darrell R, additional, Sandmaier, Brenda M., additional, Till, Brian G., additional, Balkin, Ethan R, additional, Hamlin, Don K, additional, Wilbur, D.Scott, additional, Orcutt, Kelly D, additional, Wittrup, K. Dane, additional, and Press, Oliver W., additional

Published
2015
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15. α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation

Author

Frost, Sofia H.L., primary, Miller, Brian W., additional, Bäck, Tom A., additional, Santos, Erlinda B., additional, Hamlin, Donald K., additional, Knoblaugh, Sue E., additional, Frayo, Shani L., additional, Kenoyer, Aimee L., additional, Storb, Rainer, additional, Press, Oliver W., additional, Wilbur, D. Scott, additional, Pagel, John M., additional, and Sandmaier, Brenda M., additional

Published
2015
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16. Quantitative single-particle digital autoradiography withα-particle emitters for targeted radionuclide therapy using the iQID camera

Author

Miller, Brian W., primary, Frost, Sofia H. L., additional, Frayo, Shani L., additional, Kenoyer, Aimee L., additional, Santos, Erlinda, additional, Jones, Jon C., additional, Green, Damian J., additional, Hamlin, Donald K., additional, Wilbur, D. Scott, additional, Fisher, Darrell R., additional, Orozco, Johnnie J., additional, Press, Oliver W., additional, Pagel, John M., additional, and Sandmaier, Brenda M., additional

Published
2015
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17. Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

Author

Frost, Sofia H. L., primary, Frayo, Shani L., additional, Miller, Brian W., additional, Orozco, Johnnie J., additional, Booth, Garrett C., additional, Hylarides, Mark D., additional, Lin, Yukang, additional, Green, Damian J., additional, Gopal, Ajay K., additional, Pagel, John M., additional, Bäck, Tom A., additional, Fisher, Darrell R., additional, and Press, Oliver W., additional

Published
2015
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18. A Preclinical Model of CD38-Pretargeted Radioimmunotherapy for Plasma Cell Malignancies

Author

Green, Damian J., primary, Orgun, Nural N., additional, Jones, Jon C., additional, Hylarides, Mark D., additional, Pagel, John M., additional, Hamlin, Donald K., additional, Wilbur, D.S., additional, Lin, Yukang, additional, Fisher, Darrell R., additional, Kenoyer, Aimee L., additional, Frayo, Shani L., additional, Gopal, Ajay K., additional, Orozco, Johnnie J., additional, Gooley, Theodore A., additional, Wood, Brent L., additional, Bensinger, William I., additional, and Press, Oliver W., additional

Published
2014
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19. Anti-CD38 Pretargeted Radioimmunotherapy Eradicates Multiple Myeloma Xenografts In a Murine Model

Author

Green, Damian J., primary, Jones, Jon C., additional, Hylarides, Mark D., additional, Hamlin, Donald K., additional, Wilbur, D Scott, additional, Lin, Yukang, additional, Kenoyer, Aimee L., additional, Frayo, Shani L., additional, Bensinger, William I., additional, Gopal, Ajay K., additional, Orozco, Johnnie J., additional, Gooley, Theodore A., additional, Wood, Brent L., additional, Pagel, John M., additional, and Press, Oliver W., additional

Published
2013
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20. Anti-CD45 Monoclonal Antibody (MAb) Dose Optimization For Astatine-211 (211At)-Radioimmunotherapy (RIT) Of Relapsed Non-Hodgkin Lymphoma (NHL) In a Canine Model

Author

Frost, Sofia H.L., primary, Santos, Erlinda B., additional, Miller, Brian W., additional, Bäck, Tom A., additional, Hamlin, Donald K., additional, Wilbur, D. Scott, additional, Kenoyer, Aimee L., additional, Frayo, Shani L., additional, Press, Oliver W., additional, Storb, Rainer, additional, Sandmaier, Brenda M., additional, and Pagel, John M., additional

Published
2013
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21. Bendamustine (Treanda®)-Based Regimens Are Effective In Mobilizing Peripheral Blood Hematopoietic Stem Cells For Autologous Transplantation

Author

Green, Damian J., primary, Bensinger, William I., additional, Holmberg, Leona, additional, Gooley, Theodore A., additional, Till, Brian G., additional, Budde, Lihua Elizabeth, additional, Pagel, John M., additional, Frayo, Shani L., additional, Roden, Jennifer E., additional, Hedin, Lacey M., additional, Mack, Malcolm, additional, Press, Oliver W., additional, and Gopal, Ajay K., additional

Published
2013
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22. Astatine-211 Conjugated To Anti-CD20 Monoclonal Antibody Eliminates B-Cell Lymphoma In a Mouse Model

Author

Green, Damian J., primary, Shadman, Mazyar, additional, Frayo, Shani L., additional, Jones, Jon C., additional, Hylarides, Mark D., additional, Kenoyer, Aimee L., additional, Wilbur, D. Scott, additional, Hamlin, Donald K., additional, Lin, Yukang, additional, Gopal, Ajay K., additional, Frost, Sofia H.L., additional, Orozco, Johnnie J., additional, Pagel, John M., additional, and Press, Oliver W., additional

Published
2013
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23. Anti-CD45 Pretargeted Radioimmunotherapy Prior to Bone Marrow Transplantation without Total Body Irradiation Facilitates Engraftment From Haploidentical Donors and Prolongs Survival in a Disseminated Murine Leukemia Model

Author

Orozco, Johnnie J., primary, Kenoyer, Aimee, additional, Balkin, Ethan, additional, Hamlin, Donald K., additional, Wilbur, Scott, additional, Fisher, Darrell R., additional, Mawad, Raya, additional, Frayo, Shani L., additional, Hylarides, Mark D., additional, Green, Damian J., additional, Gopal, Ajay K., additional, O'Donnell, Paul V., additional, Sandmaier, Brenda M., additional, Press, Oliver W., additional, and Pagel, John M., additional

Published
2013
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24. Anti-CD45 Radioimmunotherapy Using the Alpha-Emitting Radionuclide 211At Combined with Bone Marrow Transplantation Prolongs Survival in a Disseminated Murine Leukemia Model

Author

Orozco, Johnnie J., primary, Kenoyer, Aimee, additional, Bäck, Tom, additional, Balkin, Ethan R., additional, Hamlin, Donald K., additional, Wilbur, D Scott, additional, Fisher, Darrell R., additional, Frayo, Shani L., additional, Hylarides, Mark D., additional, Green, Damian J., additional, Gopal, Ajay K., additional, Press, Oliver W., additional, and Pagel, John M., additional

Published
2012
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25. Bendamustine (Treanda®), Etoposide and Dexamethasone (BED) Followed by GCSF Effectively Mobilizes Autologous Peripheral Blood Hematopoietic Stem Cells

Author

Green, Damian J., primary, Bensinger, William I., additional, Holmberg, Leona, additional, Gooley, Theodore A., additional, Till, Brian G., additional, Budde, Lihua Elizabeth, additional, Frayo, Shani L., additional, Roden, Jennifer E., additional, Hedin, Lacey, additional, Press, Oliver W., additional, and Gopal, Ajay K., additional

Published
2012
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26. Anti-CD45 Radioimmunotherapy Facilitates Donor Engraftment and Prolongs Survival in the Absence of TBI Prior to Haploidentical Bone Marrow Transplantation in a Disseminated Murine Leukemia Model

Author

Orozco, Johnnie J., primary, Kenoyer, Aimee, additional, Balkin, Ethan R., additional, Hamlin, Donald K., additional, Wilbur, D Scott, additional, Fisher, Darrell R., additional, Frayo, Shani L., additional, Hylarides, Mark D., additional, Green, Damian J., additional, Gopal, Ajay K., additional, O'Donnell, Paul, additional, Press, Oliver W., additional, and Pagel, John M., additional

Published
2012
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27. Conventional Anti-CD45 Radioimmunotherapy Comparing 90Y or 177Lu for Treatment of AML in a Syngeneic Disseminated Murine Leukemia Model,

Author

Orozco, Johnnie J., primary, Kenoyer, Aimee, additional, Axtman, Amanda, additional, Frayo, Shani L., additional, Morris, Paul J., additional, Hamlin, Donald K., additional, Wilbur, D. Scott, additional, Fisher, Darrell R., additional, Hylarides, Mark D., additional, Green, Damian J., additional, Gopal, Ajay K., additional, Gooley, Ted, additional, Press, Oliver W., additional, and Pagel, John M., additional

Published
2011
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28. Anti-CD38 Pretargeted Radioimmunotherapy Demonstrates Therapeutic Efficacy In a Human Multiple Myeloma Mouse Xenograft Model

Author

Green, Damian J., primary, Orgun, Nural N., additional, Hylarides, Mark D., additional, Pagel, John M., additional, Hamlin, Donald K., additional, Wilbur, D. Scott, additional, Lin, Yukang, additional, Kenoyer, Amiee L., additional, Frayo, Shani L., additional, Bensinger, William I., additional, Gopal, Ajay K., additional, Orozco, Johnnie J., additional, Gooley, Theodore A., additional, Wood, Brent L., additional, and Press, Oliver W., additional

Published
2011
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30. Quantitative single-particle digital autoradiography with α-particle emitters for targeted radionuclide therapy using the iQID camera.

Author

Miller, Brian W., Frost, Sofia H. L., Frayo, Shani L., Kenoyer, Aimee L., Santos, Erlinda, Jones, Jon C., Green, Damian J., Hamlin, Donald K., Wilbur, D. Scott, Fisher, Darrell R., Orozco, Johnnie J., Press, Oliver W., Pagel, John M., and Sandmaier, Brenda M.

Subjects
AUTORADIOGRAPHY, RADIOIMMUNOTHERAPY, MONOCLONAL antibodies, CELL death, RADIATION damage, RADIOACTIVITY
Abstract

Purpose: Alpha-emitting radionuclides exhibit a potential advantage for cancer treatments because they release large amounts of ionizing energy over a few cell diameters (50–80 μm), causing localized, irreparable double-strand DNA breaks that lead to cell death. Radioimmunotherapy (RIT) approaches using monoclonal antibodies labeled with α emitters may thus inactivate targeted cells with minimal radiation damage to surrounding tissues. Tools are needed to visualize and quantify the radioactivity distribution and absorbed doses to targeted and nontargeted cells for accurate dosimetry of all treatment regimens utilizing α particles, including RIT and others (e.g., Ra-223), especially for organs and tumors with heterogeneous radionuclide distributions. The aim of this study was to evaluate and characterize a novel single-particle digital autoradiography imager, the ionizing-radiation quantum imaging detector (iQID) camera, for use in α-RIT experiments. Methods: The iQID camera is a scintillator-based radiation detection system that images and identifies charged-particle and gamma-ray/x-ray emissions spatially and temporally on an event-by-event basis. It employs CCD-CMOS cameras and high-performance computing hardware for real-time imaging and activity quantification of tissue sections, approaching cellular resolutions. In this work, the authors evaluated its characteristics for α-particle imaging, including measurements of intrinsic detector spatial resolutions and background count rates at various detector configurations and quantification of activity distributions. The technique was assessed for quantitative imaging of astatine-211 (211At) activity distributions in cryosections of murine and canine tissue samples. Results: The highest spatial resolution was measured at ~20 μm full width at half maximum and the α-particle background was measured at a rate as low as (2.6 ± 0.5) × 10−4 cpm/cm² (40 mm diameter detector area). Simultaneous imaging of multiple tissue sections was performed using a large-area iQID configuration (ø 11.5 cm). Estimation of the 211At activity distribution was demonstrated at mBq/μg-levels. Conclusions: Single-particle digital autoradiography of α emitters has advantages over traditional film-based autoradiographic techniques that use phosphor screens, in terms of spatial resolution, sensitivity, and activity quantification capability. The system features and characterization results presented in this study show that the iQID is a promising technology for microdosimetry, because it provides necessary information for interpreting alpha-RIT outcomes and for predicting the therapeutic efficacy of cell-targeted approaches using α emitters. [ABSTRACT FROM AUTHOR]

Published
2015
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31. Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models.

Author

Frost, Sofia H. L., Frayo, Shani L., Miller, Brian W., Orozco, Johnnie J., Booth, Garrett C., Hylarides, Mark D., Lin, Yukang, Green, Damian J., Gopal, Ajay K., Pagel, John M., Bäck, Tom A., Fisher, Darrell R., and Press, Oliver W.

Subjects
*LUTETIUM isotopes, *COMPARATIVE studies, *YTTRIUM isotopes, *XENOGRAFTS, *RADIOIMMUNOTHERAPY, *LYMPHOMAS
Abstract

Purpose: Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice. Methods: Parallel experiments evaluating the biodistribution, imaging, dosimetry, therapeutic efficacy, and toxicity were performed in female athymic nude mice bearing either Ramos (Burkitt lymphoma) or Granta (mantle cell lymphoma) xenografts, utilizing an anti-CD20 antibody-streptavidin conjugate (1F5-SA) and an 90Y- or 177Lu-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-biotin second step reagent. Results: The two radionuclides displayed comparable biodistributions in tumors and normal organs; however, the absorbed radiation dose delivered to tumor was more than twice as high for 90Y (1.3 Gy/MBq) as for 177Lu (0.6 Gy/MBq). More importantly, therapy with 90Y-DOTA-biotin was dramatically more effective than with 177Lu-DOTA-biotin, with 100% of Ramos xenograft-bearing mice cured with 37 MBq 90Y, whereas 0% were cured using identical amounts of 177Lu-DOTA-biotin. Similar results were observed in mice bearing Granta xenografts, with 80% of the mice cured with 90Y-PRIT and 0% cured with 177Lu-PRIT. Toxicities were comparable with both isotopes. Conclusion: 90Y was therapeutically superior to 177Lu for streptavidin-biotin PRIT approaches in these human lymphoma xenograft models. [ABSTRACT FROM AUTHOR]

Published
2015
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