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BACKGROUND: We aimed to describe our experience with gabapentin use in infants admitted to our neonatal intensive care unit (NICU), including neurodevelopmental follow-up after discharge. METHODS: We performed a retrospective medical record review of infants prescribed gabapentin during admission to the University of Virginia NICU from 01/01/2015 to 04/30/2021. We report clinical characteristics including gabapentin indication, dosing and side-effects while in the NICU, discharge data, and assessments in outpatient developmental follow-up clinic. RESULTS: Gabapentin was prescribed to 104 infants (median gestational age 29 weeks, median postmenstrual age at initiation 41 weeks). Sixty-one percent of infants were male. The primary indication was irritability in 86%, and 67% were receiving at least one other neurosedative medication. Median maximum dose was 25 mg/kg/day (IQR 15–35 mg/kg/day) and 84% were discharged home on gabapentin. The majority required equipment at discharge (64% gastrostomy or nasogastric tube feeds, 54% supplemental oxygen or mechanical ventilation, and 40% both). At the first neurodevelopmental follow-up appointment, at least one area of delay was identified in 93% of infants and by 2 years corrected age 66% had a diagnosis of global developmental delay. CONCLUSIONS: NICU patients treated with gabapentin often require complex post-discharge care and require close neurodevelopmental follow up. [ABSTRACT FROM AUTHOR]

Swine are considered to be one of the major animal species used in translational research, surgical models, and procedural training and are increasingly being used as an alternative to the dog or monkey as the choice of nonrodent species in preclinical toxicologic testing of pharmaceuticals. There are unique advantages to the use of swine in this setting given that they share with humans similar anatomic and physiologic characteristics involving the cardiovascular, urinary, integumentary, and digestive systems. However, the investigator needs to be familiar with important anatomic, histopathologic, and clinicopathologic features of the laboratory pig and minipig in order to put background lesions or xenobiotically induced toxicologic changes in their proper perspective and also needs to consider specific anatomic differences when using the pig as a surgical model. Ethical considerations, as well as the existence of significant amounts of background data, from a regulatory perspective, provide further support for the use of this species in experimental or pharmaceutical research studies. It is likely that pigs and minipigs will become an increasingly important animal model for research and pharmaceutical development applications. [ABSTRACT FROM PUBLISHER]

The article discusses the study concerning the perception of custom harvesters (CH) on regulations affecting regulations, factors of accidents and ability to train the employees on safety equipment operation in North America. Findings reveal that CH prefers to hire an individual with combine or truck operating experience or general farm experience. They believe that lost-time accidents are caused by inexperience and impatience of employees as well as fatigue. CH recognize that the are capable to train the employees, and knowledgeable on the rules of U.S. Department of Transportation (DOT). Regular evaluation of DOT regulations is suggested to update the specifics applicable to them.

Polishing composite restorations at recall prophylaxis may affect their surface roughness. This investigation evaluated the effect of prophy paste on the surface roughness of a microfilled (Filtek A110) and a microhybrid (Filtek Z250) resin composite before and after simulted toothbrushing. Twenty, two-sided samples of both materials were fabricated in acrylic molds against a Mylar strip (baseline). Three roughness readings were recorded for each surface using a Surfanalyzer 5400 to determine the mean roughness. The samples were finished and polished with Sof-Lex disk system and the surface roughness (Ra) was re-measured. Samples were randomly assigned and five surfaces for each material were polished with Nupro coarse, medium, fine or Clinpro prophy paste and the surface roughness measured again. All surfaces were brushed 60,000 times at 1.5Hz using a 2N brushhead (manly V-8 cross-brushing machine) in a 50:50 (w/w) slurry of toothpaste and water. The surface roughness was measured followed by the application of prophy paste as previously described and this final roughness recorded. Data were analyzed using repeated measures two-factor ANOVA with TUKEY HSD pairwise comparison as appropriate (a=0.05). No significant difference in surface roughness was determined between the microfilled and microhybrid materials at baseline or disk treatment, yet significant differences were observed following brushing and/or prophy paste application. In conclusion, although baseline and disk treated surfaces were not significantly different in microfilled versus microhybrid composites, subsequent prophy paste application and/or simulated toothbrushing caused significant differences. [ABSTRACT FROM AUTHOR]

Many polishing protocols have been evaluated in vitro for their effect on the surface roughness of restorative materials. These results have been useful in establishing protocols for in vivo application. However, limited research has focused on the subsequent care and maintenance of esthetic restorations following their placement. This investigation evaluated the effect of five polishing protocols that could be implemented t recall on the surface roughness of five direct esthetic restorative materials. Specimens (n=25) measuring 8 mm diameter X 3 mm thick were fabricated in an acrylic mold using five light-cured resin-based materials (hybrid composite, microfilled composite, packable composite, compomer and resin-modified glass ionomer). After photopolymerization, all specimens were polished with Sof-Lex Disks to produce an initial (baseline) surface finish. All specimens were then polished with one of five prophylactic protocols (Butler medium paste, Butler coarse paste, OneGloss, SuperBuff or OneGloss & SuperBuff). The average surface roughness of each treated specimen was determined from three measurements with a profilometer (Surface 1). Next, all specimens were brushed 60,000 times at 1.5Hz using a brush-head force of 2 N on a Manly V-8 cross-brushing machine in a 50:50 (w/w) slurry of toothpaste and water. The surface roughness of each specimen was measured after brushing (Surface 2) followed by re-polishing with one of five protocols, then final surface roughness values were determined (Surface 3). The data were analyzed using repeated measures ANOVA. Significant differences (p=0.05) in surface roughness were observed among restorative materials and polishing protocols. The microfilled and hybrid resin composite yielded significantly rougher surfaces than the other three materials following tooth brushing. Prophylactic polishing protocols can be used to restore a smooth surface on resin-based esthetic restorative materials following simulated tooth brushing. [ABSTRACT FROM AUTHOR]