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4. The “End Life” of the Grape Pomace Waste Become the New Beginning: The Development of a Virtuous Cycle for the Green Synthesis of Gold Nanoparticles and Removal of Emerging Contaminants from Water

Author

Gubitosa, Jennifer, primary, Rizzi, Vito, additional, Laurenzana, Anna, additional, Scavone, Francesca, additional, Frediani, Elena, additional, Fibbi, Gabriella, additional, Fanelli, Fiorenza, additional, Sibillano, Teresa, additional, Giannini, Cinzia, additional, Fini, Paola, additional, and Cosma, Pinalysa, additional

Published
2022
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5. Olive phenols preserve lamin B1 expression reducing cGAS/STING/NFκB‐mediated SASP in ionizing radiation‐induced senescence

Author

Frediani, Elena, primary, Scavone, Francesca, additional, Laurenzana, Anna, additional, Chillà, Anastasia, additional, Tortora, Katia, additional, Cimmino, Ilaria, additional, Leri, Manuela, additional, Bucciantini, Monica, additional, Mangoni, Monica, additional, Fibbi, Gabriella, additional, Del Rosso, Mario, additional, Mocali, Alessandra, additional, Giovannelli, Lisa, additional, and Margheri, Francesca, additional

Published
2022
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6. Erratum to: Parvovirus B19 induces cellular senescence in human dermal fibroblasts: putative role in systemic sclerosis-associated fibrosis

Author

Arvia, Rosaria, primary, Zakrzewska, Krystyna, additional, Giovannelli, Lisa, additional, Ristori, Sara, additional, Frediani, Elena, additional, Del Rosso, Mario, additional, Mocali, Alessandra, additional, Stincarelli, Maria A, additional, Laurenzana, Anna, additional, Fibbi, Gabriella, additional, and Margheri, Francesca, additional

Published
2022
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7. Parvovirus B19 induces cellular senescence in human dermal fibroblasts: putative role in systemic sclerosis–associated fibrosis

Author

Arvia, Rosaria, primary, Zakrzewska, Krystyna, additional, Giovannelli, Lisa, additional, Ristori, Sara, additional, Frediani, Elena, additional, Del Rosso, Mario, additional, Mocali, Alessandra, additional, Stincarelli, Maria A, additional, Laurenzana, Anna, additional, Fibbi, Gabriella, additional, and Margheri, Francesca, additional

Published
2021
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9. Parvovirus B19 induces cellular senescence in human dermal fibroblasts: putative role in systemic sclerosis–associated fibrosis.

Author

Arvia, Rosaria, Zakrzewska, Krystyna, Giovannelli, Lisa, Ristori, Sara, Frediani, Elena, Rosso, Mario Del, Mocali, Alessandra, Stincarelli, Maria A, Laurenzana, Anna, Fibbi, Gabriella, and Margheri, Francesca

Subjects
PARVOVIRUS diseases, CYTOKINES, FIBROBLASTS, SYSTEMIC scleroderma, FIBROSIS, CELLULAR aging, GENE expression, MESSENGER RNA, DNA damage, PHENOTYPES, DISEASE complications
Abstract

Objective Emerging evidence demonstrates that excessive accumulation of senescent cells is associated with some chronic diseases and suggests a pathogenic role of cellular senescence in fibrotic processes, such as that occurring in ageing or in SSc. Recently we demonstrated that parvovirus B19 (B19V) activates normal human dermal fibroblasts and induces expression of different profibrotic/pro-inflammatory genes. This observation prompted us to investigate whether it is also able to induce fibroblast senescence as a potential pathogenetic mechanism in B19V-induced fibrosis. Methods Primary cultures of fibroblasts were infected with B19V and analysed for the acquisition of senescence markers, such as morphological modifications, senescence-associated β-galactosidase (SA-β-gal) activity, DNA damage response and expression of senescence-associated secretory phenotype (SASP)-related factors. Results We demonstrated that B19V-infected fibroblasts develop typical senescence features such as enlarged and flat-shaped morphology and SA-β-gal activity similar to that observed in SSc skin fibroblasts. They also developed an SASP-like phenotype characterized by mRNA expression and release of some pro-inflammatory cytokines, along with activation of the transcription factor nuclear factor κB. Moreover, we observed B19V-induced DNA damage with the comet assay: a subpopulation of fibroblasts from B19V-infected cultures showed a significantly higher level of DNA strand breaks and oxidative damage compared with mock-infected cells. An increased level and nuclear localization of γH2AX, a hallmark of DNA damage response, were also found. Conclusions B19V-induced senescence and production of SASP-like factors in normal dermal fibroblasts could represent a new pathogenic mechanism of non-productive B19V infection, which may have a role in the fibrotic process. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Water Diffusion Effects at Gold–Graphene Interfaces Supporting Surface Plasmon Polaritons

Author

Zaman, Quaid, Tahir, Freire, Fernando Lazaro, Shtepliuk, Ivan, Barbosa, Andre N., Maia da Costa, Marcelo E. H., Diaz Mendoza, Cesar Augusto, Araujo, Jefferson F. D. F, Concas, Guilherme C., Cremona, Marco, Ahmed, Zubair, Ginoble Pandoli, Omar, Aucelio, Ricardo Q., Dmitriev, Victor, da Costa, Karlo Q., Cruz, André Felipe S., Fibbi, Gabriella, Laurenzana, Anna, Margheri, Francesca, Chillà, Anastasia, Scavone, Francesca, Frediani, Elena, Khan, Rajwali, Daldosso, Nicola, Chistè, Elena, Mariotto, Gino, Santos, Evelyn C. S., and Del Rosso, Tommaso

Abstract

We present a detailed investigation on the effects of water diffusion at the different interfaces of gold–graphene plasmonic sensors on the propagation of the supported surface plasmon polaritons (SPPs). The substrate/metal interfacial chemical reactions are investigated by monitoring the full width at half-maximum of the SPR reflectivity curve. Although protection by single-layer graphene (SLG) grown by chemical vapor deposition inhibits the chemical reactions happening at the metal–dielectric interfaces, SPR experimental results confirm that water diffusion paths through the borders of graphene domains are still present into the plasmonic sensors. Density functional theory calculations show that the doping level of SLG after the transfer on gold as well as interfacial charge transfer can be tuned in the presence of water molecules. On these bases, we propose a simplified effective medium approach for heterogeneous metal–carbon interfaces, where the interaction between the surface atomic layers of the gold thin film, water molecules, and the SLG induces the creation of an extended charge density difference region crossing the Au/H2O/SLG/H2O heterointerface. The latter is modeled as an ultrathin effective medium with a thickness and extraordinary optical susceptivity and conductivity that are different from those of the free-standing graphene. In this context, the extraordinary refractive index and thickness of the graphene–gold effective medium are measured in the near-infrared on the low-damping SPR platforms by applying the two-medium SPR method. The results are coherent with graphene n-doping in water environment, showing that the optically excited electrons along the extraordinary axis have a substantial bonding character and that the enhancement of the sensitivity of the gold–graphene plasmonic sensors is not related to a shift in the plasma frequency of the metal layer but to the changes in the extraordinary polarizability of graphene. The research highlights the importance of the SLG–substrate and SLG–environment interactions in graphene-protected plasmonics and optoelectronics.

Published
2022
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