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Your search keyword '"Freire de Lima, Marco Edilson"' showing total 15 results
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15 results on '"Freire de Lima, Marco Edilson"'

1. A novel protocol for the synthesis of 1,2,4-oxadiazoles active against trypanosomatids and drug-resistant leukemia cell lines

Author

Pitasse-Santos, Paulo, Salustiano, Eduardo, Pena, Raynna Bittencourt, Chaves, Otavio Augusto, Fonseca, Leonardo Marques da, da Costa, Kelli Monteiro, Nascimento Santos, Carlos Antonio do, Reis, Jhenifer Santos Dos, Santos, Marcos Andre Rodrigues da Costa, Previato, Jose Osvaldo, Previato, Lucia Mendonca, Freire-de-Lima, Leonardo, Romeiro, Nelilma Correia, Pinto-da-Silva, Lucia Helena, Freire-de-Lima, Celio G, Decote-Ricardo, Debora, and Freire-de-Lima, Marco Edilson

Published
2022

3. Peracetylation of polyphenols under rapid and mild reaction conditions.

Author

de Alcântara Pinto, Douglas Chaves, Pitasse-Santos, Paulo, de Souza, Gabriela Alves, Castro, Rosane Nora, and Freire de Lima, Marco Edilson

Subjects
POLYPHENOLS, CHEMICAL yield, ACETIC anhydride, HYDROGEN bonding, HYDROXYL group
Abstract

Structural modifications are an important tool for studying the properties of naturally occurring polyphenols. Regarding the preparation of acetyl esters, the presence of hydroxyl groups stabilized by intramolecular hydrogen bonds may pose an obstacle for the peracetylation of these compounds. In this paper, we present a facile protocol for the acetylation of selected polyphenols under mild reaction conditions by using acetic anhydride, catalytic amount 4-dimethylaminopyridine (DMAP) and dimethylformamide (DMF) as solvent. Reaction conditions were adjusted for optimal formation of peracetylated polyphenols while minimizing the formation of byproducts. Butyric anhydride was employed as an alternative acylating agent and showed similar results. Reaction yields varied from 78–97%, and products were obtained in high purity, as determined by LCMS(ESI+), 1H NMR and 13C NMR. [ABSTRACT FROM AUTHOR]

Published
2023
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4. The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation

Author

Diniz-Lima, Israel, primary, da Fonseca, Leonardo Marques, additional, dos Reis, Jhenifer Santos, additional, Rodrigues da Costa Santos, Marcos André, additional, da Costa, Kelli Monteiro, additional, do Nascimento Santos, Carlos Antonio, additional, Barcelos, Pedro Marçal, additional, Guimarães-Pinto, Kamila, additional, Filardy, Alessandra Almeida, additional, Freire-de-Lima, Marco Edilson, additional, Decote-Ricardo, Debora, additional, Morrot, Alexandre, additional, Freire-de-Lima, Celio Geraldo, additional, and Freire-de-Lima, Leonardo, additional

Published
2022
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7. COVID-19 Infection and Neuropathological Features

Author

Freire-de-Lima, Leonardo, primary, Scovino, Aline Miranda, additional, Marques da Fonseca, Leonardo, additional, Barreto Menezes, Camilla Cristie, additional, Santos, Carlos Antonio do Nascimento, additional, Freire de Lima, Marco Edilson, additional, Decote-Ricardo, Debora, additional, Freire-de-Lima, Matheus, additional, da Costa, Kelli Monteiro, additional, dos Reis, Jhenifer Santos, additional, Rodrigues da Costa Santos, Marcos André, additional, Freire-de-Lima, Celio Geraldo, additional, and Morrot, Alexandre, additional

Published
2021
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8. Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells

Author

Marques da Fonseca, Leonardo, primary, Jacques da Silva, Lucas Rodrigues, additional, Santos dos Reis, Jhenifer, additional, Rodrigues da Costa Santos, Marcos André, additional, de Sousa Chaves, Victoria, additional, Monteiro da Costa, Kelli, additional, Sa-Diniz, Julliana de Nazareth, additional, Freire de Lima, Celio Geraldo, additional, Morrot, Alexandre, additional, Nunes Franklim, Tatiany, additional, de Alcântara-Pinto, Douglas Chaves, additional, Freire de Lima, Marco Edilson, additional, Previato, Jose Osvaldo, additional, Mendonça-Previato, Lucia, additional, and Freire-de-Lima, Leonardo, additional

Published
2020
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9. The Effectiveness of Natural Diarylheptanoids against Trypanosoma cruzi: Cytotoxicity, Ultrastructural Alterations and Molecular Modeling Studies

Author

Sueth-Santiago, Vitor, primary, Moraes, Julliane de B. B., additional, Sobral Alves, Eliomara Sousa, additional, Vannier-Santos, Marcos André, additional, Freire-de-Lima, Célio G., additional, Castro, Rosane N., additional, Mendes-Silva, Gustavo Peron, additional, Del Cistia, Catarina de Nigris, additional, Magalhães, Luma Godoy, additional, Andricopulo, Adriano Defini, additional, Sant´Anna, Carlos Mauricio R., additional, Decoté-Ricardo, Debora, additional, and Freire de Lima, Marco Edilson, additional

Published
2016
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10. Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1.

Author

da Silva Cardoso, Verônica, Vermelho, Alane Beatriz, Ribeiro de Lima, Cristina Amorim, Mendes de Oliveira, Jéssica, Freire de Lima, Marco Edilson, Pinto da Silva, Lúcia Helena, Direito, Glória Maria, and das Graças Miranda Danelli, Maria

Subjects
ALKALOIDS, BROILER chickens, AFLATOXINS, BLACK pepper (Plant), CARCINOGENESIS, CELL-mediated cytotoxicity, GENETIC toxicology, ASPERGILLUS
Abstract

Piperine is an abundant amide extracted from black pepper seeds which has been shown to have protective effects against cytotoxic and genotoxic carcinogenesis induced by certain chemical carcinogens and aflatoxin B1 (AFB1) in vitro. The aim of this work was to study, in vivo, the antigenotoxic potential of feed-added piperine on broiler chickens experimentally intoxicated with AFB1, using micronucleus and comet assays. The antigenotoxicity assessment of 9-day-old chicks was performed on a total of 60 chickens divided into four groups of 15 broilers each: (C) control, (P) 60 mg·piperine kg-1 feed, (A) 0.5 mg·AFB1·kg-1 body weight, (daily by oral route), and (P + A) co-treatment with piperine and AFB1. The experiment was conducted for 26 days. Chicks intoxicated with AFB1 showed significant genotoxic effects in the first 24 h post intoxication, and the effects remained in the other periods analyzed (48, 72, and 96 h and 26 days of treatment). The DNA damage in peripheral blood cells, the number of erythrocytes with micronuclei, and polychromatic-to-normochromatic erythrocyte ratio were significantly reduced or absent in the piperine/AFB1 group. No significant differences were observed between the group piperine/AFB1 and the control and piperine-alone groups. The addition 60 mg·kg-1 of piperine to the diet of the broiler chicks was safe, promoting beneficial effects in poultry health with respect to the toxic effects 0.5 mg·AFB1·kg-1 body weight. [ABSTRACT FROM AUTHOR]

Published
2016
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15. [Insecticide effects of natural amides from Piper and of the synthetic derivative tetrahydropiperine on Lucilia cuprina (Diptera: Calliphoridae) and Musca domestica (Diptera: Muscidae)].

Author

Barbieri E Jr, Barreto CB Jr, Ribeiro RC, de Oliveira VH, Freire de Lima ME, and Moya-Borja GE

Subjects
Animals, Diptera, Alkaloids, Benzodioxoles, Houseflies, Insecticides, Piper nigrum, Piperidines, Polyunsaturated Alkamides
Abstract

The insecticide activity of piperine, cinamoil amide, and tetrahydropiperine against Lucilia cuprina and Musca domestica adults were conducted at the Federal Rural University of Rio de Janeiro. Chemicals were topically applied on thoracic areas of the flies and the toxicity was determined after 24 and 48 hr post treatment and LD50 were calculated using Probit Analysis. Tetrahydropiperine (THP amide) was the only substance which demonstrated insecticide activity against both species of flies. LD50 against L. cuprina and M. domestica were 16.25 and 7.65 microg/fly, respectively, after 24 hr of treatment. Similar results were observed after 48 hr post treatment because the LD50's were 18.03 and 6.57 microg/fly, respectively. Males of L. cuprina were more resistant to tetrahydropiperine than females. However females of M. domestica were more resistant to the insecticide than males.

Published
2007

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