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16 results on '"French Institute for Public Health Research (IRESP)"'

1. Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder (PICOC)

Author: Laboratoire de Psychologie des Cognitions (Strasbourg University, France), ICube Laboratory - Team IGG (Strasbourg University, France), Hospital Center of Saint-Esprit (Martinique), National Cancer Institute, France, French Institute for Public Health Research (IReSP), GIRCI SOHO, and Thomas Lehoux, Ph.D. Candidate
Published: 2024

2. Prevalence and socioeconomic and geographical inequalities of household food insecurity in the Paris region, France, 2010

Author: Judith Martin-Fernandez, Francesca Grillo, Isabelle Parizot, France Caillavet, Pierre Chauvin, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe de recherches sur les inégalités sociales (ERIS) / Equipe du Centre Maurice Halbwachs (ERIS-CMH), Centre Maurice Halbwachs (CMH), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-École des hautes études en sciences sociales (EHESS), Alimentation et sciences sociales (ALISS), Institut National de la Recherche Agronomique (INRA), French National Research Agency (ANR), French Institute of public health research (IRESP) and French Interministerial Committee of Urban Affairs. It received also some supports from the Mutualité Française., École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Département de Sciences sociales ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Département de Sciences sociales ENS-PSL, BMC, Ed., ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins (DS3), Laboratoire de Recherche sur la Consommation (CORELA), and This research has been funded by the French National Research Agency (ANR), the French Institute of public health research (IRESP) and the French Interministerial Committee of Urban Affairs. It received also some supports from the Mutualité Française. J. Martin has received a PhD grant from the Ile-de-France region for this research.
Subjects: Paris, 030309 nutrition & dietetics, Cross-sectional study, Population, Food Supply, 03 medical and health sciences, Neighbourhood effect, 0302 clinical medicine, Residence Characteristics, Risk Factors, Surveys and Questionnaires, Environmental health, food insecurity, région parisienne, Prevalence, Humans, Medicine, 030212 general & internal medicine, education, Socioeconomic status, 2. Zero hunger, Family Characteristics, 0303 health sciences, education.field_of_study, business.industry, 1. No poverty, Public Health, Environmental and Occupational Health, insecurité alimentaire, 3. Good health, nutrition, inégalité sociale, Cross-Sectional Studies, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Income, Multilevel Analysis, Household income, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Biostatistics, business, france, Research Article, Cohort study, Poverty threshold
Abstract: International audience; BACKGROUND: Food insecurity (FI) is the situation where people do not have, at all times, access to sufficient, safe and nutritious food that meets their dietary needs for an active and healthy life. The objectives of this study were to estimate the prevalence of FI in the Paris area by using, for the first time in France, a specific FI questionnaire and to identify the characteristics of food-insecure households, taking into account a potential neighbourhood effect. METHODS: This study is based on data from the third wave of the SIRS cohort study (a representative, population-based socioepidemiological study) that were analysed using a cross-sectional design. In 2010, 3000 individuals in the Paris metropolitan area (PMA) were interviewed. FI was investigated by means of the USDA's HFSSM. We used stratified multilevel models across three household income categories to identify populations at risk for FI. RESULTS: In 2010, 6.30% (95% CI = [4.99-7.97]) of the households in the PMA experienced FI (up to 13.59% in the most underprivileged neighbourhoods). About 2.50% of the households experienced severe FI and 2.85% of household living with an income above 1666 € experienced food insecurity, whereas the percentage raises to 23.38% among those living below the poverty threshold (< 791 €). Depending on the income level, different household characteristics emerged as being associated with FI. In the poorest households, the presence of a child under 3 years of age was associated with an increased risk of FI (OR = 2.11; p = 0.03). Among higher-income households, the household composition appeared to be strongly associated with FI. CONCLUSION: FI exists in several social groups in France. Its prevalence in the most underprivileged households should be considered an indicator of vulnerability, which could permit targeted social assistance policies.
Published: 2013
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3. Study protocol for a pragmatic cluster randomized controlled trial to improve dietary diversity and physical fitness among older people who live at home (the 'ALAPAGE study')

Author: Aurélie, Bocquier, Anne-Fleur, Jacquemot, Christophe, Dubois, Hélène, Tréhard, Chloé, Cogordan, Gwenaëlle, Maradan, Sébastien, Cortaredona, Lisa, Fressard, Bérengère, Davin-Casalena, Agnès, Vinet, Pierre, Verger, Nicole, Darmon, Valérie, Arquier, Guillaume, Briclot, Rachel, Chamla, Florence, Cousson-Gélie, Sarah, Danthony, Karin, Delrieu, Julie, Dessirier, Catherine, Féart, Christine, Fusinati, Rozenn, Gazan, Mélissa, Gibert, Valérie, Lamiraud, Matthieu, Maillot, Dolorès, Nadal, Christelle, Trotta, Eric O, Verger, Valérie, Viriot, Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Trophis [ Les Pennes Mirabeau], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), Avignon Université (AU), Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) (UMR MoISA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), French Institute for Public Health Research (IReSP) : LI-DARMONAAP18-PREV-004, Regional Health Agency Provence-Alpes-Cote d'Azur (ARS PACA), Southeastern France retirement fund (Carsat Sud-Est), Region Sud - Provence-Alpes-Cote d'Azur, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), and Bocquier, Aurélie
Subjects: Quality of life, Dietary diversity, Physical activity, Cost-Benefit Analysis, Loneliness, Elderly people, Cluster randomized controlled trial, Health education, Physical Fitness, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Healthy ageing, Pragmatic Clinical Trials as Topic, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Lifestyle integrated functional exercise, Geriatrics and Gerontology, Diet, Healthy, Exercise, Aged, Nutrition
Abstract: Background Diet and physical activity are key components of healthy aging. Current interventions that promote healthy eating and physical activity among the elderly have limitations and evidence of French interventions’ effectiveness is lacking. We aim to assess (i) the effectiveness of a combined diet/physical activity intervention (the “ALAPAGE” program) on older peoples’ eating behaviors, physical activity and fitness levels, quality of life, and feelings of loneliness; (ii) the intervention’s process and (iii) its cost effectiveness. Methods We performed a pragmatic cluster randomized controlled trial with two parallel arms (2:1 ratio) among people ≥60 years old who live at home in southeastern France. A cluster consists of 10 people participating in a “workshop” (i.e., a collective intervention conducted at a local organization). We aim to include 45 workshops randomized into two groups: the intervention group (including 30 workshops) in the ALAPAGE program; and the waiting-list control group (including 15 workshops). Participants (expected total sample size: 450) will be recruited through both local organizations’ usual practices and an innovative active recruitment strategy that targets hard-to-reach people. We developed the ALAPAGE program based on existing workshops, combining a participatory and a theory-based approach. It includes a 7-week period with weekly collective sessions supported by a dietician and/or an adapted physical activity professional, followed by a 12-week period of post-session activities without professional supervision. Primary outcomes are dietary diversity (calculated using two 24-hour diet recalls and one Food Frequency Questionnaire) and lower-limb muscle strength (assessed by the 30-second chair stand test from the Senior Fitness Test battery). Secondary outcomes include consumption frequencies of main food groups and water/hot drinks, other physical fitness measures, overall level of physical activity, quality of life, and feelings of loneliness. Outcomes are assessed before the intervention, at 6 weeks and 3 months later. The process evaluation assesses the fidelity, dose, and reach of the intervention as its causal mechanisms (quantitative and qualitative data). Discussion This study aims to improve healthy aging while limiting social inequalities. We developed and evaluated the ALAPAGE program in partnership with major healthy aging organizations, providing a unique opportunity to expand its reach. Trial registration ClinicalTrials.gov Identifier: NCT05140330, December 1, 2021. Protocol version: Version 3.0 (November 5, 2021).
Published: 2022
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4. Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Author: Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude, Johanna Lepeule, Chard-Hutchinson, Xavier, APPEL À PROJETS GÉNÉRIQUE 2018 - Exposition prénatale au tabac et à la pollution atmosphérique et effets sur la santé respiratoire et le neurodévelopment de l'enfant: rôle de la méthylation placentaire - - ETAPE2018 - ANR-18-CE36-0005 - AAPG2018 - VALID, Contaminants et Environnements : Santé, Adaptabilité, Comportements et Usages - Effets de la Pollution Atmosphérique sur la fonction Placentaire et le développement Post-natal - - EPPAP2013 - ANR-13-CESA-0011 - CESA - VALID, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Harvard T.H. Chan School of Public Health, École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), French National Cancer Institute (INCa), French Institute for Public Health Research (IreSP) [INCa_13641], Fondation de France [2012-00031593, 2012-00031617], European Union, Diabetes National Research Program (French Association of Diabetic Patients (AFD)), ANSES, Mutuelle Generale de l'Education Nationale (MGEN), French National Agency for Food Security, Frenchspeaking Association for the Study of Diabetes and Metabolism (ALFEDIAM), Foundation for Medical Research (FRM), National Institute for Research in Public Health (IRESP: TGIR cohorte sante 2008 program), French Ministry of Health (DGS), French Ministry of Research, Inserm Bone and Joint Diseases National Research (PRO-A), Human Nutrition National Research Programs, Paris-Sud University, Nestle, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), ANR-18-CE36-0005,ETAPE,Exposition prénatale au tabac et à la pollution atmosphérique et effets sur la santé respiratoire et le neurodévelopment de l'enfant: rôle de la méthylation placentaire(2018), and ANR-13-CESA-0011,EPPAP,Effets de la Pollution Atmosphérique sur la fonction Placentaire et le développement Post-natal(2013)
Subjects: [SDV]Life Sciences [q-bio], Placenta, Mesenchymal stromal cells, Blood Pressure, General Medicine, DNA Methylation, Cell-type heterogeneity, Epigenesis, Genetic, [SDV] Life Sciences [q-bio], Cohort Studies, Epigenome-wide association study, Pregnancy, Hypertension, Humans, Female, CpG Islands, Child
Abstract: Background Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy and proper maternal-fetal exchanges through the placenta and are very sensitive to numerous environmental stressors. Maternal hypertension during pregnancy has been associated with impaired placental functions and with an increased risk for children to suffer from cardiovascular and respiratory diseases later on. Investigating changes in placental DNA methylation levels and cell-type composition in association with maternal blood pressure could help elucidate its relationships with placental and fetal development. Methods Taking advantage of a large cohort of 666 participants, we investigated the association between epigenome-wide DNA methylation patterns in the placenta, measured using the Infinium HumanMethylation450 BeadChip, placental cell-type composition, estimated in silico, and repeated measurements of maternal steady and pulsatile blood pressure indicators during pregnancy. Results At the site-specific level, no significant association was found between maternal blood pressure and DNA methylation levels after correction for multiple testing (false discovery rate < 0.05), but 5 out of 24 previously found CpG associations were replicated (p-value < 0.05). At the regional level, our analyses highlighted 64 differentially methylated regions significantly associated with at least one blood pressure component, including 35 regions associated with mean arterial pressure levels during late pregnancy. These regions were found enriched for genes implicated in lung development and diseases. Further mediation analyses show that a significant part of the association between steady blood pressure—but not pulsatile pressure—and placental methylation can be explained by alterations in placental cell-type composition. In particular, elevated blood pressure levels are associated with a decrease in the ratio between mesenchymal stromal cells and syncytiotrophoblasts, even in the absence of preeclampsia. Conclusions This study provides the first evidence that the association between maternal steady blood pressure during pregnancy and placental DNA methylation is both direct and partly explained by changes in cell-type composition. These results could hint at molecular mechanisms linking maternal hypertension to lung development and early origins of childhood respiratory problems and at the importance of controlling maternal blood pressure during pregnancy.
Published: 2022
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5. Housing environment and mental health of Europeans during the COVID-19 pandemic: a cross-country comparison

Author: Amélie Keller, Jonathan Groot, Joane Matta, Feifei Bu, Tarik El Aarbaoui, Maria Melchior, Daisy Fancourt, Marie Zins, Marcel Goldberg, Anne-Marie Nybo Andersen, Naja H. Rod, Katrine Strandberg-Larsen, Tibor V. Varga, University of Copenhagen = Københavns Universitet (UCPH), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), University College of London [London] (UCL), PRJ-2019-00020, 09‐067124, March of Dimes Foundation, MDF, AstraZeneca, Sundhed og Sygdom, Det Frie Forskningsråd, FSS, DFF: 271‐08‐0839/06‐066023, SSVF 0646, Natur og Univers, Det Frie Forskningsråd, FNU, DFF: DFF—4183‐00152, DFF—4183‐00594, Velux Fonden: 36336, Pfizer Foundation, Merck Sharp and Dohme, MSD, Wellcome Trust, WT: 205407/Z/16/Z, 221400/Z/20/Z, UK Research and Innovation, UKRI: ES/S002588/1, National Health Insurance Administration, NHI, Nuffield Foundation: WEL/FR-000022583, Health Foundation, Cardiff University, Swansea University, Agence Nationale de la Recherche, ANR: -10-COHO-06, -20-COVI-000, ANR-11-INBS-0002, Institut National de la Santé et de la Recherche Médicale, Inserm: 20-26, Københavns Universitet, KU, Fondation pour la Recherche Médicale, FRM: 20RR052-00, Lundbeckfonden: R100‐A9193, Nordea-fonden: 02‐2013‐2014, AU R9‐A959‐13‐S804, Institut National Du Cancer, INCa, Egmont Fonden, H. Lundbeck A/S, This study was made possible by a grant from the RealDania Foundation (PRJ-2019-00020 ‘Indoor environment and child health…’). The DNBC was established with a significant grant from the Danish National Research Foundation. Additional support was obtained from the Danish Regional Committees, the Pharmacy Foundation, the Egmont Foundation, the March of Dimes Birth Defects Foundation, the Health Foundation and other minor grants. Follow‐up of mothers and children has been supported by the Danish Medical Research Council (SSVF 0646, 271‐08‐0839/06‐066023, O602‐01042B, 0602‐02738B), the Lundbeck Foundation (195/04, R100‐A9193), The Innovation Fund Denmark 0603‐00294B (09‐067124), the Nordea Foundation (02‐2013‐2014), Aarhus Ideas (AU R9‐A959‐13‐S804), a University of Copenhagen Strategic Grant (IFSV 2012) and the Danish Council for Independent Research (DFF—4183‐00594 and DFF—4183‐00152). Follow-up of mother and children in the COVID-19 data collection was supported by a grant from the Velux Foundation (grant number 36336, ‘Standing together at a distance—How Danes are living with the Corona Crisis’). The TEMPO cohort received funding from the French National Research Agency (ANR) including the Flash COVID-19 funding scheme, the French Institute for Public Health Research-IReSP (TGIR Cohortes), the French Inter-departmental Mission for the Fight against Drugs and Drug Addiction (MILDeCA), the French Institute of Cancer (INCa), and the Pfizer Foundation. The CONSTANCES COVID-19 Study was funded by: ANR (Agence Nationale de la Recherche, #ANR-20-COVI-000, #ANR-10-COHO-06), Fondation pour la Recherche Médicale (#20RR052-00), Inserm (Institut National de la Santé et de la Recherche Médicale, #C20-26). The CONSTANCES Cohort Study was supported and funded by the French National Health Insurance Fund ('Caisse nationale d’assurance maladie', CNAM). The CONSTANCES Cohort Study is an 'Infrastructure nationale en Biologie et Santé' and benefits from a grant from the French National Agency for Research (ANR-11-INBS-0002). CONSTANCES is also partly funded by Merck Sharp & Dohme (MSD), AstraZeneca, Lundbeck and L’Oréal. None of these funding sources had any role in the design of the study, collection and analysis of data or decision to publish. The Covid-19 Social Study was funded by the Nuffield Foundation [WEL/FR-000022583], but the views expressed are those of the authors and not necessarily the Foundation. The study was also supported by the MARCH Mental Health Network funded by the Cross-Disciplinary Mental Health Network Plus initiative supported by UK Research and Innovation [ES/S002588/1], and by the Wellcome Trust [221400/Z/20/Z]. DF was funded by the Wellcome Trust [205407/Z/16/Z]. The researchers are grateful for the support of a number of organisations with their recruitment efforts including: the UKRI Mental Health Networks, Find Out Now, UCL BioResource, SEO Works, FieldworkHub, and Optimal Workshop. The study was also supported by HealthWise Wales, the Health and Care Research Wales initiative, which is led by Cardiff University in collaboration with SAIL, Swansea University. The funders had no role in the study design, data collection, data analysis, interpretation, the writing of the report, and decisions on where to publish., The authors thank the INSERM-Versailles Saint Quentin en Yvelines University ?Population-based Epidemiologic Cohorts Unit? (Cohortes ?pid?miologiques en population) which designed and manages the Constances Cohort Study. They also thank the National Health Insurance Fund (?Caisse nationale d?assurance maladie des travailleurs salaries,? CNAMTS) and its Health Screening Centres (?Centres d?examens de sant??), which are collecting a large part of the data, as well as the National Old-Age Insurance Fund (Caisse nationale d?assurance vieillesse) for its contribution to the constitution of the cohort, ClinSearch, Asqualab and Eurocell, which are conducting the data quality control., ANR-10-COHO-0006,E4N,Etude Epidémiologique des Enfants de femmes de l'Education Nationale(2010), ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011), HAL UVSQ, Équipe, Cohortes - Etude Epidémiologique des Enfants de femmes de l'Education Nationale - - E4N2010 - ANR-10-COHO-0006 - COHO - VALID, and Infrastructures - La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance - - CONSTANCES2011 - ANR-11-INBS-0002 - INBS - VALID
Subjects: Family Characteristics, Multidisciplinary, DISORDERS, [SDV]Life Sciences [q-bio], COVID-19, ADULTS, [SDV] Life Sciences [q-bio], Crowding, Mental Health, POOLED ANALYSES, Communicable Disease Control, Housing, Humans, ANXIETY, COHORT, Pandemics, LONELINESS, COMMON, METAANALYSIS
Abstract: Many studies have investigated the impact of the COVID-19 pandemic on mental health. Throughout the pandemic, time spent at home increased to a great extent due to restrictive measures. Here we set out to investigate the relationship between housing conditions and the mental health of populations across European countries. We analyzed survey data collected during spring 2020 from 69,136 individuals from four cohorts from Denmark, France, and the UK. The investigated housing conditions included household density, composition, and crowding, access to outdoor facilities, dwelling type, and urbanicity. The outcomes were loneliness, anxiety, and life satisfaction. Logistic regression models were used, and results were pooled using random-effects meta-analysis. In the meta-analysis, living alone was associated with higher levels of loneliness (OR = 3.08, 95% CI 1.87–5.07), and lower life satisfaction (OR = 1.27, 95% CI 1.05–0.55), compared to living with others. Not having access to an outdoor space and household crowding were suggestively associated with worse outcomes. Living in crowded households, living alone, or lacking access to outdoor facilities may be particularly important in contributing to poor mental health during a lockdown. Addressing the observed fundamental issues related to housing conditions within society will likely have positive effects in reducing social inequalities, as well as improving preparedness for future pandemics.
Published: 2022
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6. Antibiotic prophylaxis in preterm premature rupture of membranes at 24–31 weeks’ gestation: Perinatal and 2‐year outcomes in the EPIPAGE‐2 cohort

Author: Lorthe, Elsa, Letouzey, Mathilde, Torchin, Héloïse, Foix L'Helias, Laurence, Gras‐le Guen, Christèle, Benhammou, Valérie, Boileau, Pascal, Charlier, Caroline, Kayem, Gilles, Ancel, Pierre‐yves, Arnaud, Catherine, Blanc, Julie, Debillon, Thierry, Delorme, Pierre, D’ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Gascoin, Géraldine, Gire, Catherine, Goffinet, François, Langer, Bruno, Maisonneuve, Emeline, Marret, Stéphane, Monier, Isabelle, Morgan, Andrei, Rozé, Jean‐christophe, Schmitz, Thomas, Sentilhes, Loïc, Subtil, Damien, Tosello, Barthélémy, Vayssière, Christophe, Winer, Norbert, Zeitlin, Jennifer, Astruc, D, Kuhn, P, Matis, J, Ramousset, C, Hernandorena, X, Chabanier, P, Joly‐pedespan, L, Costedoat, Mj, Leguen, A, Lecomte, B, Lemery, D, Vendittelli, F, Beucher, G, Dreyfus, M, Guillois, B, Toure, Y, Burguet, A, Couvreur, S, Gouyon, Jb, Sagot, P, Colas, N, Sizun, J, Beuchée, A, Pladys, P, Rouget, F, Dupuy, Rp, Soupre, D, Charlot, F, Roudaut, S, Favreau, A, Saliba, E, Reboul, L, Bednarek, N, Morville, P, Verrière, V, Thiriez, G, Balamou, C, Marpeau, L, Barbier, C, Durrmeyer, X, Granier, M, Ayoubi, M, Baud, O, Carbonne, B, Jarreau, Ph, Mitanchez, D, Duffaut, C, Cornu, L, Moras, R, Boulot, P, Cambonie, G, Daudé, H, Badessi, A, Tsaoussis, N, Bédu, A, Mons, F, Bahans, C, Binet, Mh, Fresson, J, Hascoët, Jm, Milton, A, Morel, O, Vieux, R, Hilpert, L, Alberge, C, Baron, M, Charkaluk, Ml, Pierrat, V, Truffert, P, Akowanou, S, Simeoni, U, Bongain, A, Deschamps, M, Branger, B, Rouger, V, Dupont, C, Gondry, Jean, Krim, G, Baby, B, Debeir, M, Claris, O, Picaud, Jc, Rubio‐gurung, S, Cans, C, Ego, A, Patural, H, Rannaud, A, Janky, E, Poulichet, A, Rosenthal, Jm, Coliné, E, Favre, A, Joly, N, Châlons, S, Pignol, J, Laurence, Pl, Robillard, Py, Samperiz, S, Ramful, D, Blondel, B, Bonet, M, Brinis, A, Coquelin, A, Durox, M, Kaminski, M, Khemache, K, Khoshnood, B, Lebeaux, C, Marchand‐martin, L, Rousseau, J, Saurel‐cubizolles, Mj, Tran, D, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier universitaire de Nantes (CHU Nantes), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris], Assistance Publique - Hôpitaux de Paris, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service Epidémiologie clinique et santé publique [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Unité de biostatistiques [Centre Georges-François Leclerc], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Médecine Néonatale et Réanimation Pédiatrique CHU Grenoble, CHU Grenoble, Service de gynécologie-obstétrique [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Service de Néonatologie, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Recherches épidémiologiques en santé périnatale et santé des femmes, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 (GRAMFC), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Funding information:This work was partly supported by a postdoctoral grant from the Fondation des Treilles to EL. EPIPAGE-2 was funded by the French Institute of Public Health Research (IRESP TGIR 2009-01 programme)/Institute of Public Health and its partners: the French Health Ministry, the National Institute of Health and Medical Research (INSERM), the National Institute of Cancer, and the National Solidarity Fund for Autonomy (CNSA), the National Research Agency through the French EQUIPEX programme of investments for the future (grant number ANR-11-EQPX-0038), and the PREMUP Foundation. Additional funding was obtained from Fondation pour la Recherche Medicale (grant number SPF 20160936356) and Fondation de France (grant numbers 00050329, Grand Prix R18202KK]). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript., ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Education, Formation, Travail, Savoirs (EFTS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Centre Hospitalier Universitaire [Grenoble] (CHU), Modélisation et Évaluation des données complexes en Santé Publique (TIMC-MESP), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Dijon, Hôpital Nord [CHU - APHM], Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Department of Obstetrics and Gynecology, Les Hôpitaux Universitaires de Strasbourg (HUS), EPIPAGE-2 Study Group, and Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Fetal Membranes, Premature Rupture, obstetric intervention, [SDV]Life Sciences [q-bio], Gestational Age, antenatal management, Cohort Studies, Pregnancy, Escherichia coli, Humans, Prospective Studies, latency, amoxicillin, neurodevelopment, macrolides, prematurity, Infant, Newborn, Pregnancy Outcome, Obstetrics and Gynecology, Infant, prophylactic antibiotics, Antibiotic Prophylaxis, Anti-Bacterial Agents, perinatal outcome, cephalosporins, Premature Birth, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neonatal Sepsis, Infant, Premature
Abstract: To compare different antibiotic prophylaxis administered after preterm premature rupture of membranes to determine whether any were associated with differences in obstetric and/or neonatal outcomes and/or neurodevelopmental outcomes at 2 years of corrected age.Prospective, nationwide, population-based EPIPAGE-2 cohort study of preterm infants.France, 2011.We included 492 women with a singleton pregnancy and a diagnosis of preterm premature rupture of membranes at 24-31 weeks. Exclusion criteria were contraindication to expectant management or indication for antibiotic therapy other than preterm premature rupture of membranes. Antibiotic prophylaxis was categorised as amoxicillin (n = 345), macrolide (n = 30), third-generation cephalosporin (n = 45) or any combinations covering Streptococcus agalactiae and90% of Escherichia coli (n = 72), initiated within 24 hours after preterm premature rupture of membranes.Population-averaged robust Poisson models.Survival at discharge without severe neonatal morbidity, 2-year neurodevelopment.With amoxicillin, macrolide, third-generation cephalosporin and combinations, 78.5%, 83.9%, 93.6% and 86.0% of neonates were discharged alive without severe morbidity. The administration of third-generation cephalosporin or any E. coli-targeting combinations was associated with improved survival without severe morbidity (adjusted risk ratio 1.25 [95% confidence interval 1.08-1.45] and 1.10 [95 % confidence interval 1.01-1.20], respectively) compared with amoxicillin. We evidenced no increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.In preterm premature rupture of membranes at 24-31 weeks, antibiotic prophylaxis based on third-generation cephalosporin may be associated with improved survival without severe neonatal morbidity when compared with amoxicillin, with no evidence of increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.Antibiotic prophylaxis after PPROM at 24-31 weeks: 3rd-generation cephalosporins associated with improved neonatal outcomes.
Published: 2022
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7. Impact of work arrangements during the COVID-19 pandemic on mental health in France

Author: Irwin Hecker, Tarik El Aarbaoui, Solène Wallez, Astrid Juhl Andersen, José Luis Ayuso-Mateos, Richard Bryant, Giovanni Corrao, David McDaid, Roberto Mediavilla, Ellenor Mittendorfer-Rutz, Matteo Monzio Compagnoni, A-La Park, Antje Riepenhausen, Thomas Rigotti, Katharina Seeber, Marit Sijbrandij, Pierre Smith, Oliver Tüscher, Henrik Walter, Anke Witteveen, Murielle Mary-Krause, Maria Melchior, Hecker, I, El Aarbaoui, T, Wallez, S, Andersen, A, Ayuso-Mateos, J, Bryant, R, Corrao, G, Mcdaid, D, Mediavilla, R, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Park, A, Riepenhausen, A, Rigotti, T, Seeber, K, Sijbrandij, M, Smith, P, Tüscher, O, Walter, H, Witteveen, A, Mary-Krause, M, Melchior, M, Clinical Psychology, APH - Mental Health, World Health Organization (WHO) Collaborating Center, Equipe de Recherche en Epidémiologie Sociale [iPLesp] (ERES), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), School of Psychology, University of New South Wales [Sydney] (UNSW), Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB)-Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Care Policy and Evaluation Centre, London School of Economics and Political Science (LSE), Instituto de Investigacion Hospital La Paz (IdiPAZ), Foundation for Biomedical Research, Hospital Universitario La Paz [Madrid, Spain]-Hospital Universitario La Paz [Madrid, Spain]-Hospital Universitario La Paz-School of Nursing Building, Division of Insurance Medicine, Karolinska Institutet [Stockholm], University of Milano-Bicocca -University of Milano-Bicocca, Research Division of Mind and Brain, Department of Psychiatry and Neurosciences, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Berlin School of Mind and Brain [Berlin], Humboldt University Of Berlin, Department of Work, Organizational and Business Psychology, Institute of Psychology, Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU)-Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Institut de recherche santé et société [Louvain, Belgium] (IRSS), Université Catholique de Louvain = Catholic University of Louvain (UCL), Department of Clinical, Neuro, and Developmental Psychology, Vrije Universiteit Amsterdam [Amsterdam] (VU), Sciensano [Bruxelles], Réseau International des Instituts Pasteur (RIIP), Leibniz Institute for Resilience Research, Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Department of Clinical, Neuro and Developmental Psychology, The TEMPO cohort is supported by the French National Research Agency (ANR), the French Institute for Public Health Research-IReSP (TGIR Cohortes), the French Inter-departmental Mission for the Fight against Drugs and Drug Addiction (MILDeCA), the French Institute of Cancer (INCa) and the Pfizer Foundation. The TEMPO COVID-19 study is supported by the European Union’s Horizon 2020 research and innovation program RESPOND (The RESPOND project is funded under Horizon 2020 – the Framework Programme for Research and Innovation (2014-2020). The content of this article reflects only the authors’ views and the European Community is not liable for any use that may be made of the information contained therein).+, European Project: RESPOND, and Leibniz Institute for Resilience Research [Mainz, Allemagne] (LIR Mainz)
Subjects: Health (social science), BF Psychology, Depression, Health Policy, Public Health, Environmental and Occupational Health, COVID-19, cohort, Anxiety, HV Social pathology. Social and public welfare. Criminology, work, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, RA0421 Public health. Hygiene. Preventive Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Mental health, France, COVID
Abstract: International audience; Background: The COVID-19 pandemic has been accompanied by an increase in symptoms of anxiety/depression in the French population. Work and financial difficulties may contribute to this deterioration of mental health however, to date, longitudinal prospective data are lacking on how work arrangements are associated with mental distress.Objective: Our study aims to better understand relationships between work arrangements and financial difficulties during the COVID-19 pandemic and individuals’ patterns of symptoms of anxiety/depression, while controlling for pre-pandemic factors, including employment and financial characteristics as well as mental health.Methods: Data were gathered for the TEMPO Project, a 30-year follow-up cohort study aiming to better understand trajectories of mental health. Between March 2020 and July 2021, 904 participants completed at least one of nine questionnaires aiming to specifically evaluate living circumstances and mental health during the COVID-19 pandemic.Results: In adjusted generalized estimating equations models controlling for participants’ demographic characteristics as well as employment and mental health prior to the COVID-19 pandemic, we found that individuals who were unemployed during the pandemic were more likely to report symptoms of anxiety/depression (OR = 1.89; 95% CI = 1.07-3.33) compared to those with stable employment. Similarly, persons who had financial difficulties during the pandemic had higher levels of symptoms of anxiety/depression (OR = 1.43; 95% CI = 0.99-2.07) than those who did not have such difficulties.Conclusion: Adults who were unemployed or experiencing financial difficulties during the COVID-19 pandemic were more likely to show elevated levels of symptoms of anxiety/depression. Importantly, this increased risk of poor mental health was not explained by pre-existing socioeconomic or mental health difficulties. Our study highlights the role of social determinants in shaping the risk of mental health difficulties; these should be targeted by interventions aiming to improve population wellbeing in the context of a pandemic.
Published: 2022
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8. Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells

Author: Isabelle Fronval, Gianni Zarcone, Sébastien Anthérieu, Guillaume Garçon, Jean-Marc Lo-Guidice, Véronique Riffault, Romain Dusautoir, Delphine Allorge, Marie Verriele, Nicolas Beauval, Nadine Locoge, Université de Lille, CHU Lille, Institut Pasteur de Lille, Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS], Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Lille Douai], Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre for Energy and Environment (CERI EE), Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Lille Douai), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut Mines-Télécom [Paris] (IMT), French Institute of Cancer (INCa_11505 and INCa_13648), French Institute for Public Health Research (IResP), Centre for Energy and Environment (CERI EE - IMT Nord Europe), and Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Nord Europe)
Subjects: Environmental Engineering, Health, Toxicology and Mutagenesis, Inflammatory response, 0211 other engineering and technologies, 02 engineering and technology, 010501 environmental sciences, Heat-not-burn tobacco, Electronic Nicotine Delivery Systems, 01 natural sciences, PAHs, Carbonyls, Smoke, Tobacco, Environmental Chemistry, Cigarette smoke, Humans, Lung, Toxicity, e-Cigarette, Food science, Waste Management and Disposal, 0105 earth and related environmental sciences, Aerosols, 021110 strategic, defence & security studies, Chemistry, Tobacco Products, Pollution, 3. Good health, 13. Climate action, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDE]Environmental Sciences
Abstract: International audience; The electronic cigarettes (e-cigs) and more recently the heated tobacco products (HTP) provide alternatives for smokers as they are generally perceived to be less harmful than conventional cigarettes. However, it is crucial to compare the health risks of these different emergent devices, in order to determine which product should be preferred to substitute cigarette. The present study aimed to compare the composition of emissions from HTP, e-cigs and conventional cigarettes, regarding selected harmful or potentially harmful compounds, and their toxic impacts on the human bronchial epithelial BEAS-2B cells. The HTP emitted less polycyclic aromatic hydrocarbons and carbonyls than the conventional cigarette. However, amounts of these compounds in HTP aerosols were still higher than in e-cig vapours. Concordantly, HTP aerosol showed reduced cytotoxicity compared to cigarette smoke but higher than e-cig vapours. HTP and e-cig had the potential to increase oxidative stress and inflammatory response, in a manner similar to that of cigarette smoke, but after more intensive exposures. In addition, increasing e-cig power impacted levels of certain toxic compounds and related oxidative stress. This study provides important data necessary for risk assessment by demonstrating that HTP might be less harmful than tobacco cigarette but considerably more harmful than e-cig.
Published: 2020
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9. Illness beliefs and emotional responses in mildly disabled stroke survivors: A qualitative study

Author: Della Vecchia, Claire, Préau, Marie, Carpentier, Camille, Viprey, Marie, Haesebaert, Julie, Termoz, Anne, Dima, Alexandra L., Schott, Anne-Marie, Bodescot, Myriam, MARVELOUS - - MARVELOUS2016 - ANR-16-RHUS-0009 - RHUS - VALID, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Groupe de Recherche en Psychologie Sociale (GRePS), Université Lumière - Lyon 2 (UL2), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pôle de Santé Publique [Lyon], Hospices Civils de Lyon (HCL), CDV was supported by a PhD grant from the Auvergne Rhône-Alpes region. This work was supported by the RHU MARVELOUS (ANR-16-RHUS-0009) of l’Université Claude Bernard Lyon 1 (UCBL), within the program 'Investissements d’Avenir' operated by the French National Research Agency (ANR), the 'Prevent’horizon' French Excellence Research Chair and the French institute of public health research (IRESP) (AAP Handicap 2015). This work was also supported by the ALLP., and ANR-16-RHUS-0009,MARVELOUS,MARVELOUS(2016)
Subjects: Male, Science, Cerebrovascular Diseases, Disabilities, Health Care Providers, Cognitive Neuroscience, Emotions, Culture, [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Social Sciences, Pathology and Laboratory Medicine, Vascular Medicine, Signs and Symptoms, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diagnostic Medicine, Surveys and Questionnaires, Mental Health and Psychiatry, Adaptation, Psychological, Medicine and Health Sciences, Psychology, Humans, Public and Occupational Health, Disabled Persons, Survivors, Fatigue, Qualitative Research, Aged, Cognitive Impairment, Aged, 80 and over, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Cognitive Neurology, Biology and Life Sciences, Middle Aged, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Stroke, Health Care, Neurology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Medicine, Cognitive Science, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Behavioral and Social Aspects of Health, Stress, Psychological, Research Article, Neuroscience
Abstract: International audience; BACKGROUND:As acute stroke services improve, more persons experience mild stroke and need to cope daily with hidden disabilities, which may be influenced by how they perceive stroke, cognitively and emotionally.OBJECTIVE:To investigate cognitive illness beliefs and emotional responses in persons with mild stroke and their possible influences on daily coping.METHODS:Semi-structured interviews were conducted with 24 persons with mild stroke, on average 7.5 months (±0.89) after stroke occurrence. A thematic analysis on verbatim transcripts was guided by the Common-Sense Model of Self-Regulation.RESULTS:All participants experienced difficulties constructing an illness identity at both acute and chronic phase. Behavioral risk factors were less accepted as causes of stroke. Lack (or inappropriate timing) of information from healthcare providers led to limited medication knowledge and low perceived control of stroke recurrence which generated anxiety, fear, and low involvement in coping. Participants who considered stroke a chronic condition experienced more difficulties. Perceived support from relatives and healthcare providers was beneficial for participation in recovery and health behaviour change.CONCLUSION:Despite having mildly disabilities, participants reported difficulties developing illness beliefs conducive to coping, and dealing with their emotional responses. These elements should be considered in tailored programs to improve coping with hidden disabilities post-stroke.
Published: 2019
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10. The Impact of Donor Type on Long-Term Health Status and Quality of Life after Allogeneic Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Leucemie de l'Enfant et de L'Adolescent Study

Author: André Baruchel, Gérard Michel, Guy Leverger, Geneviève Plat, Charlotte Jubert, Marie-Dominique Tabone, Hervé Chambost, Justyna Kanold, Catherine Paillard, Jean-Hugues Dalle, Claire Galambrun, Virginie Gandemer, Yves Bertrand, Jacinthe Bonneau, Maryline Poiree, Claire Freycon, Virginie Villes, Isabelle Pellier, Sandrine Visentin, Julie Berbis, Claire Oudin, Cécile Pochon, Anne Sirvent, Pascal Auquier, Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE), Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants (SPMC), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU), Hématologie et immunologie pédiatrique, Hospices Civils de Lyon (HCL)-CHU Lyon-Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL] (IHOPe), Hospices Civils de Lyon (HCL)-Hôpital Femme-Mère-Enfant (HFME), Service d'hématologie et immunologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Centre de référence des maladies héréditaires du métabolisme (MaMEA Nancy-Brabois), Groupe hospitalier Pellegrin, Service de Pédiatrie, Unité d'Oncologie et Hématologie Pédiatrique, Centre Hospitalier Universitaire de Nice (CHU Nice), Institut de Génétique et Développement de Rennes (IGDR), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), CHU Pontchaillou [Rennes], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hématogoie pédiatrique, hôpital Sud, Service d'oncologie médicale [CHU Strasbourg], CHU Strasbourg, Service d'hématologie pédiatrique, CHU Clermont-Ferrand-CIC Inserm 501, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service d'Hématologie pédiatrique, Hôpital de la Timone, Marseille, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CHU Toulouse [Toulouse], Hôpital Robert Debré Paris, Hôpital Robert Debré, Pédiatrie et oncologie pédiatrique [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), the French National Clinical Research Program (grant no. PHRC10-24-02), French National Cancer Institute (InCA), French National Research Agency (ANR) [2011-043], Canceropole PACA [2016-03], Regional Council PACA [2016-03], Herault and the Bouches-du-Rhone departmental comities of the Ligue Contre le Cancer, French Institute for Public Health Research (IRESP), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Jonchère, Laurent
Subjects: [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, Male, Pediatrics, Cord blood transplantation, MESH: Late effects, medicine.medical_treatment, Health Status, MESH: Quality of life, Hematopoietic stem cell transplantation, Childhood leukemia, 0302 clinical medicine, Quality of life, Child, MESH: Cord blood transplantation, Acute leukemia, Late effect, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Tissue Donors, 3. Good health, Leukemia, 030220 oncology & carcinogenesis, Child, Preschool, Female, Cord Blood Stem Cell Transplantation, medicine.symptom, Unrelated Donors, medicine.medical_specialty, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Hematopoietic stem cell transplantation, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Childhood leukemia, [SDV.CAN] Life Sciences [q-bio]/Cancer, medicine, Humans, Transplantation, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, Late effects, Infant, Odds ratio, medicine.disease, Surgery, business, 030215 immunology
Abstract: International audience; We compared the long-term impact of donor type (sibling donor [SD] versus matched unrelated donor [MUD] or umbilical cord blood [UCB]) on late side effects and quality of life (QoL) in childhood acute leukemia survivors treated with hematopoietic stem cell transplantation. We included 314 patients who underwent transplantation from 1997 to 2012 and were enrolled in the multicenter French Leucemie de l'Enfant et de L'Adolescent ("Leukemia in Children and Adolescents") cohort. More than one-third of the patients were adults at last visit; mean follow-up duration was 6.2 years. At least 1 late effect was observed in 284 of 314 patients (90.4%). The average number of adverse late effects was 2.1 +/- 1, 2.4 +/- 2, and 2.4 +/- 2 after SD, MUD, and UCB transplantation, respectively. In a multivariate analysis, considering the SD group as the reference, we did not detect an impact of donor type for most sequelae, with the exception of increased risk of major growth failure after MUD transplantation (odds ratio [OR], 2.42) and elevated risk of osteonecrosis after UCB transplantation (OR, 4.15). The adults and children's parents reported comparable QoL among the 3 groups. Adult patient QoL scores were lower than age- and sex-matched French reference scores for almost all dimensions. We conclude that although these patients are heavily burdened by long-term complications, donor type had a very limited impact on their long-term health status and QoL.
Published: 2016
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11. Late thyroid complications in survivors of childhood acute leukemia. An LEA study

Author: Gérard Michel, Marie-Dominique Tabone, Jean-Hugues Dalle, Dominique Plantaz, P Chastagner, Vincent Barlogis, Patrick Lutz, Pascal Auquier, Julie Berbis, Claire Oudin, Maryline Poiree, André Baruchel, Sandrine Thouvenin, Justyna Kanold, Yves Bertrand, Stéphane Ducassou, Virginie Villes, Guy Leverger, Anne Sirvent, Virginie Gandemer, Service d'hématologie pédiatrique, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants (SPMC), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU), Hématologie et immunologie pédiatrique, Hospices Civils de Lyon (HCL)-CHU Lyon-Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL] (IHOPe), Hospices Civils de Lyon (HCL)-Hôpital Femme-Mère-Enfant (HFME), CHU Clermont-Ferrand-CIC Inserm 501, Service de Pédiatrie, Unité d'Oncologie et Hématologie Pédiatrique, Centre Hospitalier Universitaire de Nice (CHU Nice), Hôpital Pellegrin Tripode, Service Hématologie Infantile, CHU Grenoble, Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Hôpital Robert Debré Paris, Hôpital Robert Debré, Institut de Génétique et Développement de Rennes (IGDR), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), CHU Pontchaillou [Rennes], Service de pédiatrie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Pédiatrie et oncologie pédiatrique [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service d'hématologie et immunologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), French National Clinical Research Program, French National Cancer Institute (InCA), French National Research Agency (ANR), Canceropole PACA, Regional Council PACA, Herault Departmental Comity of the Ligue Contre le Cancer, French Institute for Public Health Research (IRESP), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Paris Diderot - Paris 7 (UPD7)-Hôpital Robert Debré-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Male, MESH: Therapy/adverse effects, [SHS.PSY]Humanities and Social Sciences/Psychology, Gastroenterology, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, MESH: Child, Prevalence, Cumulative incidence, Survivors, MESH: Incidence, Child, Thyroid cancer, MESH: Combined Modality, MESH: Survivors, Acute leukemia, Leukemia, MESH: Thyroid Diseases/diagnosis, MESH: France/epidemiology, Incidence, Thyroid, Hematology, MESH: Follow-Up Studies, Total body irradiation, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Combined Modality Therapy, MESH: Leukemia/complications, 3. Good health, medicine.anatomical_structure, Child, Preschool, 030220 oncology & carcinogenesis, Acute Disease, MESH: Acute Disease, Female, France, Thyroid function, medicine.medical_specialty, MESH: Leukemia/epidemiology, MESH: Combined Modality Therapy/methods, MESH: Leukemia/therapy, MESH: Thyroid Diseases/epidemiology, Article, MESH: Multivariate Analysis, 03 medical and health sciences, Internal medicine, MESH: Thyroid Diseases/etiology, medicine, Humans, MESH: Prevalence, MESH: Humans, business.industry, MESH: Child, Preschool, medicine.disease, Thyroid Diseases, MESH: Male, Surgery, Transplantation, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Multivariate Analysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Prophylactic cranial irradiation, business, MESH: Female, Follow-Up Studies, 030215 immunology
Abstract: International audience; Thyroid complications are known side effects of irradiation. However, the risk of such complications in childhood acute leukemia survivors who received either central nervous system irradiation or hematopoietic stem cell transplantation is less described. We prospectively evaluated the incidence and risk factors for thyroid dysfunction and tumors in survivors of childhood acute myeloid or lymphoid leukemia. A total of 588 patients were evaluated for thyroid function, and 502 individuals were assessed for thyroid tumors (median follow-up duration: 12.6 and 12.5 years, respectively). The cumulative incidence of hypothyroidism was 17.3% (95% CI: 14.1-21.1) and 24.6% (95% CI: 20.4-29.6) at 10 and 20 years from leukemia diagnosis, respectively. Patients who received total body irradiation (with or without prior central nervous system irradiation) were at higher risk of hypothyroidism (adjusted HR: 2.87; P=0.04 and 2.79, P=0.01, respectively) as compared with transplanted patients who never received any irradiation. Patients transplanted without total body irradiation who received central nervous system irradiation were also at higher risk (adjusted HR: 3.39; P=0.02). Patients irradiated or transplanted at older than 10 years of age had a lower risk (adjusted HR: 0.61; P=0.02). Thyroid malignancy was found in 26 patients (5.2%). Among them, two patients had never received any type of irradiation: alkylating agents could also promote thyroid cancer. The cumulative incidence of thyroid malignancy was 9.6% (95% CI: 6.0-15.0) at 20 years. Women were at higher risk than men (adjusted HR: 4.74; P=0.002). In conclusion, thyroid complications are frequent among patients who undergo transplantation after total body irradiation and those who received prior central nervous system irradiation. Close monitoring is thus warranted for these patients. Clinicaltrials.gov identifier: NCT 01756599.
Published: 2016
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12. Prevalence and correlates of vaccine hesitancy among general practitioners: a cross-sectional telephone survey in France, April to July 2014

Author: Patrick Peretti-Watel, Aurélie Bocquier, Pierre Verger, Lisa Fressard, Jocelyn Raude, Céline Pulcini, Arnaud Gautier, Fanny Collange, Lissalde, Claire, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), REseau national d'Investigation clinique en VACcinologie (REIVAC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de Gestion des Essais de Produits de Santé (CeNGEPS), French Clinical Research Infrastructure Network [Paris] (Plateforme F-CRIN ), Alliance Nationale pour les Sciences de la vie et de la Santé [Paris] (AVIESAN), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Agence Nationale de la Santé Publique [Saint-Maurice] (ANSP), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), École des Hautes Études en Santé Publique [EHESP] (EHESP), Emergence des Pathologies Virales (EPV), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Sorbonne Paris Cité (USPC), Directorate of Research, Studies, Evaluation and Statistics (DREES) of the Ministry of Social Affairs and Health and the National Institute for Prevention and Education in Health (INPES). This research has also separately received funding from the French National ResearchAgency (call for proposals issued in 2015) and, as part of the 'Primary Prevention' call for proposals issued by the French Institute for Public Health Research (IReSP) and the INCa in 2013, from the French National Health Insurance Fund for Employees (CNAM-TS), the French Directorate General of Health (DGS), the Arc Foundation for Cancer Research, the French National Cancer Institute (INCa), the INPES, the French National Institute of Health and Medical Research (INSERM), the French Interdepartmental Agency for the Fight against Drugs and Addictive Behaviors (Mildeca) and the French Social Security Plan for the Self-Employed (RSI)., Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), INSB-INSB-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)
Subjects: 0301 basic medicine, Male, Pediatrics, Epidemiology, [SHS.SOCIO] Humanities and Social Sciences/Sociology, Alternative medicine, 0302 clinical medicine, Influenza A Virus, H1N1 Subtype, Surveys and Questionnaires, Prevalence, 030212 general & internal medicine, Practice Patterns, Physicians', [SHS.SOCIO]Humanities and Social Sciences/Sociology, Incidence, Vaccination, Professional Practice, 3. Good health, Telephone survey, Private practice, Influenza Vaccines, Global Positioning System, Female, France, General practice, Attitude of health personnel, Research Article, Adult, medicine.medical_specialty, 030106 microbiology, education, 03 medical and health sciences, Cluster analysis, General Practitioners, Virology, Influenza, Human, medicine, Humans, Adverse effect, Pandemics, Vaccine hesitancy, Behavior, Health professionals, business.industry, Vaccines and immunization, Public Health, Environmental and Occupational Health, Confidence interval, Telephone, Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Family medicine, Health Care Surveys, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: International audience; This article sought to estimate the prevalence of vaccine hesitancy (VH) among French general practitioners (GPs) and to study its demographic, professional and personal correlates. We conducted a cross-sectional telephone survey about GPs' vaccination-related attitudes and practices in 2014 in a national panel of 1,712 GPs in private practice, randomly selected from an exhaustive database of health professionals in France. A cluster analysis of various dimensions of VH (self-reported vaccine recommendations, perceptions of vaccine risks and usefulness) identified three clusters: 86% of GPs (95% confidence interval (CI): 84-88) were not or only slightly vaccine-hesitant, 11% (95% CI: 9-12) moderately hesitant and 3% (95% CI: 3-4) highly hesitant or opposed to vaccination. GPs in the latter two clusters were less frequently vaccinated and reported occasional practice of alternative medicine more often than those in the first cluster; they also described less experience with vaccine-preventable diseases and more experience with patients who they considered had serious adverse effects from vaccination. This study confirms the presence of VH among French GPs but also suggests that its prevalence is moderate. Given GPs' central role in vaccination, these results nevertheless call for a mobilisation of stake-holders to address VH among GPs.
Published: 2016
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13. Food insecurity, a determinant of obesity? - an analysis from a population-based survey in the paris metropolitan area, 2010

Author: Judith Martin-Fernandez, France Caillavet, Anne Lhuissier, Pierre Chauvin, Equipe de Recherche en Epidémiologie Sociale (ERES), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Alimentation et sciences sociales (ALISS), Institut National de la Recherche Agronomique (INRA), Epidémiologie, Systèmes d'Information, Modélisation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), French National Research Agency (ANR) within the framework of the Programme National de Recherche en Alimentation et Nutrition, French Institute for Public Health Research (IRESP) and French Interministerial Committee for Urban Affairs. It also received support from Mutualité Française. J. M-F received a PhD grant from the Île-de-France region for this research., Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Chauvin, Pierre, and Martin-Fernandez, Judith
Subjects: Gerontology, Adult, Male, Paris, Health (social science), Adolescent, Urban Population, Population, lcsh:TX341-641, Body Mass Index, Food Supply, Cohort Studies, Young Adult, Sex Factors, Physiology (medical), Environmental health, medicine, Odds Ratio, Prevalence, Humans, Longitudinal Studies, Obesity, education, Poverty, lcsh:RC620-627, Aged, 2. Zero hunger, education.field_of_study, Family Characteristics, Food security, business.industry, Multilevel model, Odds ratio, Middle Aged, medicine.disease, 3. Good health, lcsh:Nutritional diseases. Deficiency diseases, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Original Article, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Body mass index, lcsh:Nutrition. Foods and food supply, Cohort study
Abstract: Objective The relationship between food insecurity and obesity is discussed in the literature. The objective of this study was to determine whether food insecurity and obesity were associated in the Paris metropolitan area. Methods: We used data from third wave of the Health, Inequalities and Social Ruptures (SIRS) cohort study, a longitudinal population-based, representative health and socioepidemiological survey of the general population in the Paris metropolitan area. The participants' BMI (calculated using self-reported height and weight) was analyzed as a continuous variable, and a dichotomous variable (BMI < 30 kg/m2/BMI ≥ 30 kg/m2) was constructed. Food insecurity was estimated using the Household Food Security Scale Module (HFSSM) and was treated as a trichotomous variable (food security / low food security / very low food security). Multilevel models were estimated for men and women separately. Results: Obesity (BMI ≥ 30 kg/m2) prevalence was 10.2%. The determinant of obesity differs according to gender. After adjustment for age, income and the sociooccupational group, very low food security was associated with obesity in women (OR = 2.01, 95%CI 1.05-3.82), and women with very low food security had a higher BMI (Coef. = 1.78, 95% CI 0.24-3.31). This association, however, was not significant for men (OR = 1.84, 95%CI 0.64-5.30). Conclusion: In times of economic crisis, it is increasingly essential to explore and understand the pathway through which very low food security is linked to obesity.
Published: 2014
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14. A statistical procedure to create a neighborhood socioeconomic index for health inequalities analysis

Author: Benoît Lalloué, Nolwenn Le Meur, Séverine Deguen, Wahida Kihal, Cindy Padilla, Denis Zmirou-Navier, Jean-Marie Monnez, École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Modélisation Conceptuelle des Connaissances Biomédicales, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), This work and the Equit'Area project are supported by the French National Research Agency (ANR, contract-2010-PRSP-002-01) and the EHESP School of Public Health. This research was also jointly supported by the Direction Générale de la Santé (DGS), the Caisse Nationale d'Assurance Maladie des Travailleurs Salariés (CNAMTS), the Régime Social des Indépendants (RSI), the Caisse Nationale de Solidarité pour l'Autonomie (CNSA), the Mission Recherche de la Direction de la Recherche, des Etudes, de l'Evaluation et des Statistiques (MiRe-DREES) and l'Institut national de prévention et de promotion de la santé (Inpes), under the research call launched by the French Institute of Public Health Research (IReSP) in 2010., Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), and BMC, Ed.
Subjects: Multidimensional index, Index (economics), Urban Population, Principal component analysis, 03 medical and health sciences, 0302 clinical medicine, Residence Characteristics, Statistics, Cluster Analysis, Humans, 030212 general & internal medicine, Social determinants of health, Socioeconomics, Socioeconomic status, Small-Area Analysis, 030505 public health, Health Policy, Research, 1. No poverty, Public Health, Environmental and Occupational Health, Variance (accounting), Health Status Disparities, Metropolitan area, Hierarchical classification, 3. Good health, Geography, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Scale (social sciences), [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, 0305 other medical science
Abstract: International audience; INTRODUCTION: In order to study social health inequalities, contextual (or ecologic) data may constitute an appropriate alternative to individual socioeconomic characteristics. Indices can be used to summarize the multiple dimensions of the neighborhood socioeconomic status. This work proposes a statistical procedure to create a neighborhood socioeconomic index. METHODS: The study setting is composed of three French urban areas. Socioeconomic data at the census block scale come from the 1999 census. Successive principal components analyses are used to select variables and create the index. Both metropolitan area-specific and global indices are tested and compared. Socioeconomic categories are drawn with hierarchical clustering as a reference to determine "optimal" thresholds able to create categories along a one-dimensional index. RESULTS: Among the twenty variables finally selected in the index, 15 are common to the three metropolitan areas. The index explains at least 57% of the variance of these variables in each metropolitan area, with a contribution of more than 80% of the 15 common variables. CONCLUSIONS: The proposed procedure is statistically justified and robust. It can be applied to multiple geographical areas or socioeconomic variables and provides meaningful information to public health bodies. We highlight the importance of the classification method. We propose an R package in order to use this procedure.
Published: 2012
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15. Multiple imputation for estimation of an occurrence rate in cohorts with attrition and discrete follow-up time points: a simulation study

Author: Noémie Soullier, Jean Bouyer, Elise de La Rochebrochard, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national d'études démographiques (INED), Université Paris-Sud - Paris 11 (UP11), This work was supported by the French Institute for Public Health Research (IReSP), and the Ile-de-France Region [doctoral grant to NS]., BMC, Ed., and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Rural Population, Longitudinal study, Urban Population, Epidemiology, Health Informatics, Appropriate use, 01 natural sciences, Interviews as Topic, 010104 statistics & probability, 03 medical and health sciences, 0302 clinical medicine, Belgium, Statistics, medicine, Econometrics, Range (statistics), Humans, Attrition, 030212 general & internal medicine, 0101 mathematics, Longitudinal cohort, FOLLOW-UP_SURVEYS, Event (probability theory), Estimation, lcsh:R5-920, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Cumulative distribution function, Physicians, Family, Middle Aged, medicine.disease, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, SIMULATION, Polypharmacy, ATTRITION, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Health Services Research, lcsh:Medicine (General), business, METHODOLOGY, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article
Abstract: Background In longitudinal cohort studies, subjects may be lost to follow-up at any time during the study. This leads to attrition and thus to a risk of inaccurate and biased estimations. The purpose of this paper is to show how multiple imputation can take advantage of all the information collected during follow-up in order to estimate the cumulative probability P(E) of an event E, when the first occurrence of this event is observed at t successive time points of a longitudinal study with attrition. Methods We compared the performance of multiple imputation with that of Kaplan-Meier estimation in several simulated attrition scenarios. Results In missing-completely-at-random scenarios, the multiple imputation and Kaplan-Meier methods performed well in terms of bias (less than 1%) and coverage rate (range = [94.4%; 95.8%]). In missing-at-random scenarios, the Kaplan-Meier method was associated with a bias ranging from -5.1% to 7.0% and with a very poor coverage rate (as low as 0.2%). Multiple imputation performed much better in this situation (bias 83.4%). Conclusions Multiple imputation shows promise for estimation of an occurrence rate in cohorts with attrition. This study is a first step towards defining appropriate use of multiple imputation in longitudinal studies.
Published: 2010
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16. Prediction of Early Breast Cancer Metastasis from DNA Microarray Data Using High-Dimensional Cox Regression Models

Author: Thomas Filleron, Christophe Zemmour, Daniel Birnbaum, Pascal Finetti, François Bertucci, Bernard Chetrit, Jean-Marie Boher, Lissalde, Claire, Unité de Biostatistique et de Méthodologie [Institut Paoli-Calmettes, Marseille] (Département de la Recherche Clinique et de l’Innovation), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cellule Biostatistique [IUCT Oncopole, Toulouse] (Bureau des Essais Cliniques), Institut Claudius Regaud-Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), French Institute for Public Health Research (IRESP, AAR 2013–14) Inserm., Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Elastic net regularization, Cancer Research, boosting, Concordance, [SDV.CAN]Life Sciences [q-bio]/Cancer, Feature selection, [SDV.GEN] Life Sciences [q-bio]/Genetics, Computational biology, Bioinformatics, lcsh:RC254-282, cross-validation, 01 natural sciences, Cross-validation, 010104 statistics & probability, 03 medical and health sciences, breast cancer, Breast cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, genomics, metastasis, Medicine, 0101 mathematics, Original Research, 030304 developmental biology, [SDV.GEN]Life Sciences [q-bio]/Genetics, 0303 health sciences, Proportional hazards model, business.industry, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Regression, Oncology, DNA microarray, business
Abstract: Background DNA microarray studies identified gene expression signatures predictive of metastatic relapse in early breast cancer. Standard feature selection procedures applied to reduce the set of predictive genes did not take into account the correlation between genes. In this paper, we studied the performances of three high-dimensional regression methods – CoxBoost, LASSO (Least Absolute Shrinkage and Selection Operator), and Elastic net – to identify prognostic signatures in patients with early breast cancer. Methods We analyzed three public retrospective datasets, including a total of 384 patients with axillary lymph node-negative breast cancer. The Amsterdam van't Veer's training set of 78 patients was used to determine the optimal gene sets and classifiers using sensitivity thresholds resulting in misclassification of no more than 10% of the poor-prognosis group. To ensure the comparability between different methods, an automatic selection procedure was used to determine the number of genes included in each model. The van de Vijver's and Desmedt's datasets were used as validation sets to evaluate separately the prognostic performances of our classifiers. The results were compared to the original Amsterdam 70-gene classifier. Results The automatic selection procedure reduced the number of predictive genes up to a minimum of six genes. In the two validation sets, the three models (Elastic net, LASSO, and CoxBoost) led to the definition of genomic classifiers predicting the 5-year metastatic status with similar performances, with respective 59, 56, and 54% accuracy, 83, 75, and 83% sensitivity, and 53, 52, and 48% specificity in the Desmedt's dataset. In comparison, the Amsterdam 70-gene signature showed 45% accuracy, 97% sensitivity, and 34% specificity. The gene overlap and the classification concordance between the three classifiers were high. All the classifiers added significant prognostic information to that provided by the traditional prognostic factors and showed a very high overlap with respect to gene ontologies (GOs) associated with genes overexpressed in the predicted poor-prognosis vs. good-prognosis classes and centred on cell proliferation. Interestingly, all classifiers reported high sensitivity to predict the 4-year status of metastatic disease. Conclusions High-dimensional regression methods are attractive in prognostic studies because finding a small subset of genes may facilitate the transfer to the clinic, and also because they strengthen the robustness of the model by limiting the selection of false-positive predictive genes. With only six genes, the CoxBoost classifier predicted the 4-year status of metastatic disease with 93% sensitivity. Selecting a few genes related to ontologies other than cell proliferation might further improve the overall sensitivity performance.
Published: 2015
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16 results on '"French Institute for Public Health Research (IRESP)"'

1. Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder (PICOC)

2. Prevalence and socioeconomic and geographical inequalities of household food insecurity in the Paris region, France, 2010

3. Study protocol for a pragmatic cluster randomized controlled trial to improve dietary diversity and physical fitness among older people who live at home (the 'ALAPAGE study')

4. Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

5. Housing environment and mental health of Europeans during the COVID-19 pandemic: a cross-country comparison

6. Antibiotic prophylaxis in preterm premature rupture of membranes at 24–31 weeks’ gestation: Perinatal and 2‐year outcomes in the EPIPAGE‐2 cohort

7. Impact of work arrangements during the COVID-19 pandemic on mental health in France

8. Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells

9. Illness beliefs and emotional responses in mildly disabled stroke survivors: A qualitative study

10. The Impact of Donor Type on Long-Term Health Status and Quality of Life after Allogeneic Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Leucemie de l'Enfant et de L'Adolescent Study

11. Late thyroid complications in survivors of childhood acute leukemia. An LEA study

12. Prevalence and correlates of vaccine hesitancy among general practitioners: a cross-sectional telephone survey in France, April to July 2014

13. Food insecurity, a determinant of obesity? - an analysis from a population-based survey in the paris metropolitan area, 2010

14. A statistical procedure to create a neighborhood socioeconomic index for health inequalities analysis

15. Multiple imputation for estimation of an occurrence rate in cohorts with attrition and discrete follow-up time points: a simulation study

16. Prediction of Early Breast Cancer Metastasis from DNA Microarray Data Using High-Dimensional Cox Regression Models

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16 results on '"French Institute for Public Health Research (IRESP)"'

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