1. Do young adults with childhood asthma avoid occupational exposures at first hire?: Asthma related healthy worker hire effect
- Author
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Dumas, Orianne, Smit, Lidwien, Pin, Isabelle, Kromhout, Hans, Siroux, Valérie, Nadif, Rachel, Vermeulen, Roel, Heederik, Dick, Hery, Michel, Choudat, Dominique, Kauffmann, Francine, Le Moual, Nicole, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Risk Assessment Sciences [Utrecht, The Netherlands] (IRAS), Utrecht University [Utrecht], Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), Service de Pneumologie Allergologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hospital program of clinical research (PHRC)-Paris, National Research Agency - Health environment, health-work program (ANR-SEST 2005), Merck Sharp & Dohme (MSD), Isere committee against respiratory diseases (COMARES), French Agency of health safety, environment and work (AFSSET-EST-09-15), French Ministry of foreign and European affairs / Netherland organization for scientific research (NWO) Van Gogh program for French Dutch cooperation, and the University Paris Sud 11 - ED420 doctoral grant., Epidemiological Study on the Genetics and Environment of Asthma, and Nadif, Rachel
- Subjects
MESH: Adolescent ,MESH: Gases ,MESH: Healthy Worker Effect ,MESH: Humans ,MESH: Asthma ,longitudinal study ,MESH: Adult ,occupational exposure ,Asthma ,MESH: Male ,MESH: Occupational Exposure ,respiratory tract diseases ,MESH: France ,MESH: Selection Bias ,MESH: Particulate Matter ,MESH: Young Adult ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,selection bias ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,healthy worker hire effect ,MESH: Educational Status ,MESH: Longitudinal Studies ,MESH: Female - Abstract
International audience; Information on the healthy worker hire effect in relation to asthma is scant. We aimed to assess whether and how childhood asthma-related characteristics (before hire) relate to occupational exposures at first hire. Analyses were conducted in 298 children examined at the first survey of the Epidemiological Study on the Genetics and Environment of Asthma (1991-1995), who reported a training period or a job at follow-up in 2003-2007 (aged 17-29 yrs; 53% males). Exposure likelihood to dust, gases and/or fumes in their first occupation was estimated by the ALOHA job exposure matrix. Asthma before the first occupation and two asthma classifications for severity (Global Initiative for Asthma 2002 guidelines) and symptoms were defined by questionnaire. In their first job, 47% of subjects were exposed. After adjustment (age, sex and education), pre-hire onset asthmatics (59%) were nonsignificantly less likely to be exposed (OR 0.67, 95% CI 0.41-1.11). Associations were stronger when considering those with severe asthma or high symptom score in childhood (OR 0.27 (95% CI 0.11-0.63) and OR 0.49 (95% CI 0.25-0.99), respectively). The association was observed in those who completed a university degree (OR 0.55, 95% CI 0.29-1.04) but not in the others (OR 0.98, 95% CI 0.44-2.22), with consistent results for all asthma characteristics. Results suggest a healthy worker hire effect in subjects with more severe or more symptomatic asthma in childhood. Education may modulate self-selection.
- Published
- 2011