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8. Comparing Attributes: Understanding How Differences Arise and Their Importance.

Author

Lamorena, Matt and Friedel, David B.

Subjects
Basis (Taxation) -- Laws, regulations and rules -- Management -- Research, S corporations -- Finance -- Taxation -- Laws, regulations and rules -- Research, Close corporations -- Finance -- Taxation -- Research -- Laws, regulations and rules, Government regulation, Company business management, Company financing
Abstract

This column identifies common rules in tax law that affect businesses and that depend on a comparison of tax attributes. We will address several key comparisons and how differences in [...]

Published
2020

12. Per-oral Endoscopic Myotomy

Author

Stavropoulos, Stavros N., Modayil, Rani, Friedel, David, Wu, George Y., Series editor, Romanelli, John R., editor, Desilets, David J., editor, and Earle, David B., editor

Published
2017
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25. Solithromycin in Children and Adolescents with Community-acquired Bacterial Pneumonia

Author

Lang, Jason E., Hornik, Christoph P., Elliott, Carrie, Silverstein, Adam, Hornik, Chi, Al-Uzri, Amira, Bosheva, Miroslava, Bradley, John S., Borja-Tabora, Charissa Fay Corazon, John, David Di, Echevarria, Ana Mendez, Ericson, Jessica E., Friedel, David, Gonczi, Ferenc, Isidro, Marie Grace Dawn, James, Laura P., Kalocsai, Krisztina, Koutroulis, Ioannis, Laki, Istvan, Ong-Lim, Anna Lisa T., Nad, Marta, Simon, Gabor, Syed, Salma, Szabo, Eva, Benjamin, Daniel K., and Cohen-Wolkowiez, Michael

Subjects
Community-Acquired Infections, Adolescent, Pneumonia, Bacterial, Humans, Macrolides, Triazoles, Child, Article, Anti-Bacterial Agents
Abstract

BACKGROUND: Solithromycin is a new macrolide-ketolide antibiotic with potential effectiveness in pediatric community-acquired bacterial pneumonia (CABP). Our objective was to evaluate its safety and effectiveness in children with CABP. METHODS: This phase 2/3, randomized, open-label, active-control, multi-center study randomly assigned solithromycin (capsules, suspension or intravenous) or an appropriate comparator antibiotic in a 3:1 ratio (planned n=400) to children 2 months to 17 years of age with CABP. Primary safety endpoints included treatment-emergent adverse events (TEAE) and AE-related drug discontinuations. Secondary effectiveness endpoints included clinical improvement following treatment without additional antimicrobial therapy. RESULTS: Unrelated to safety, the sponsor stopped the trial prior to completion. Before discontinuation, 97 participants were randomly assigned to solithromycin (n=73) or comparator (n=24). There were 24 participants (34%, 95% CI, 23-47%) with a TEAE in the solithromycin group and 7 (29%, 95% CI, 13-51%) in the comparator group. Infusion site pain and elevated liver enzymes were the most common related AEs with solithromycin. Study drug was discontinued due to AEs in 3 subjects (4.3%) in the solithromycin group and 1 (4.2%) in the comparator group. Forty participants (65%, 95% CI, 51-76%) in the solithromycin group achieved clinical improvement on the last day of treatment versus 17 (81%, 95% CI, 58-95%) in the comparator group. The proportion achieving clinical cure was 60% (95% CI, 47-72%) and 68% (95% CI, 43-87%) for the solithromycin and comparator groups, respectively. CONCLUSION: Intravenous and oral solithromycin were generally well-tolerated and associated with clinical improvement in the majority of participants treated for CABP.

Published
2022

29. State tax consequences to shareholders on distributions of property.

Author

Friedel, David and Awuah, Yaw

Subjects
State taxation -- Laws, regulations and rules, Corporate distributions -- Taxation -- Laws, regulations and rules, Stockholders -- Taxation -- Laws, regulations and rules, Government regulation, Internal Revenue Code (I.R.C. 301(c)-301(e))
Abstract

When a company distributes property to its shareholders, tax consequences arise for the distributing corporation and the receiving shareholder. This item addresses the state tax consequences to the shareholder, which [...]

Published
2015

43. New solution creates new problems when buying member of consolidated group.

Author

Friedel, David B. and Wivagg, Elizabeth L.

Subjects
Debt financing (Corporations) -- Taxation, Consolidated tax returns -- Laws, regulations and rules, Acquisitions and mergers -- Taxation, Extinguishment of debts -- Taxation, Government regulation, Internal Revenue Code (I.R.C. 1502), Internal Revenue Code (I.R.C. 338)
Published
2010

45. New solutions to old problems when selling member of consolidated group.

Author

Friedel, David B.

Subjects
Consolidated tax returns -- Management, Affiliated corporations -- Taxation, Extinguishment of debts -- Taxation, Loss deductions -- Laws, regulations and rules, Company business management, Government regulation, Internal Revenue Code (I.R.C. 1502), Internal Revenue Code (I.R.C. 362)
Published
2009

46. Working with the final unified loss rules: the devil we now know.

Author

Friedel, David B.

Subjects
Consolidated tax returns -- Laws, regulations and rules, Basis (Taxation) -- Laws, regulations and rules, Subsidiary corporations -- Taxation, Tax elections -- Analysis, Government regulation, Internal Revenue Code (I.R.C. 338(h)(10)), Internal Revenue Code (I.R.C. 382)
Published
2009

48. Final loss disallowance rules: a new world order.

Author

Friedel, David B.

Subjects
Loss deductions -- Laws, regulations and rules, Consolidated tax returns -- Laws, regulations and rules, Stock transfer tax -- Laws, regulations and rules, Government regulation, Internal Revenue Code (I.R.C. 1502)
Published
2008

49. The practical impact of the current dual consolidated loss regulations.

Author

Friedel, David, Hong, Samuel, and Skorny, Doug

Subjects
Loss deductions -- Laws, regulations and rules, Consolidated tax returns -- Laws, regulations and rules, Tax elections -- Laws, regulations and rules, International business enterprises -- Taxation, Government regulation, Internal Revenue Code (I.R.C. 1503(d))
Published
2008

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