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12. Comparative analysis of EpCAM high-expressing and low-expressing circulating tumour cells with regard to their clonal relationship and clinical value

Author

Franken, André, Kraemer, Annika, Sicking, Alicia, Watolla, Meike, Rivandi, Mahdi, Yang, Liwen, Warfsmann, Jens, Polzer, Bernhard M., Friedl, Thomas W. P., Meier-Stiegen, Franziska, Stoecklein, Nikolas H., Dayan, Davut, Riethdorf, Sabine, Mueller, Volkmar, Pantel, Klaus, Koch, André, Hartkopf, Andreas D., Krawczyk, Natalia, Ruckhaeberle, Eugen, Niederacher, Dieter, Fehm, Tanja, and Neubauer, Hans

Published
2023
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16. Anthracycline-containing and taxane-containing chemotherapy for early-stage operable breast cancer: a patient-level meta-analysis of 100 000 women from 86 randomised trials

Author

Braybrooke, Jeremy, Bradley, Rosie, Gray, Richard, Hills, Robert K, Pan, Hongchao, Peto, Richard, Dodwell, David, McGale, Paul, Taylor, Carolyn, Aihara, Tomohiko, Anderson, Stewart, Blum, Joanne, Cardoso, Fatima, Chen, Xiaosong, Crown, John P, Ejlertsen, Bent, Friedl, Thomas W P, Harbeck, Nadia, Janni, Wolfgang, Jensen, Maj-Britt, Mamounas, Eleftherios, Narui, Kazutaka, Nitz, Ulrike, Norton, Larry, O'Shaughnessy, Joyce, Piccart, Martine, Robert, Nicholas, Shao, Zhi-Ming, Slamon, Dennis, Sparano, Joseph, Watanabe, Toru, Yothers, Greg, Yu, Ke-Da, Berry, Richard, Boddington, Clare, Clarke, Mike, Davies, Christina, Davies, Lucy, Duane, Fran, Evans, Vaughan, Gay, Jo, Gettins, Lucy, Godwin, Jon, James, Sam, Lui, Hui, Lui, Zulian, MacKinnon, Elizabeth, Mannu, Gurdeep, McHugh, Theresa, Morris, Philip, Read, Simon, Straiton, Ewan, Buzdar, Aman, Suman, Vera J, Hunt, Kelly K, Leonard, Robert C F, Mansi, Janine, Delbaldo, Catherine, Piedbois, Pascal, Quinaux, Emmanuel, Fesl, Christian, Gnant, Michael, Sölkner, Lidija, Steger, Guenther, Eikesdal, Hans Petter, Lønning, Per Eystein, Bee, Valerie, Fung, Helena, Mackey, John, Martin, Miguel, Press, Michael, De Azambuja, Evandro, Gelber, Richard, Regan, Meredith, Di Leo, Angelo, Van Dooren, Veerle, Nogaret, Jean Marie, Bartlett, John, Chen, Bingshu E, Gelmon, Karen, Goss, Paul E, Levine, Mark N, Parulekar, Wendy, Pritchard, Kathleen I, Shepherd, Lois, Berry, Donald, Cirrincione, Constance, Shulman, Lawrence N, Winer, Eric, Gelman, Rebecca S, Harris, Jay R, Henderson, Craig, Shapiro, Charles L, Christiansen, Peer, Ewertz, Marianne, Mouridsen, Henning T, Van Leeuwen, Elise, Linn, Sabine, Van Rossum, Annelot G J, Van Tinteren, Harm, Van Werkhoven, Erik, Goldstein, Lori, Gray, Robert, Eiermann, Wolfgang, Gianni, Luca, Valagussa, Pinuccia, Bogaerts, Jan, Bonnefoi, Herve, Poncet, Coralie, Huovinen, Riikka, Joensuu, Heikki, Bonneterre, Jacques, Fargeot, Pierre, Fumoleau, Pierre, Kerbrat, Pierre, Luporsi, Elisabeth, Namer, Moïse, Carrasco, Eva M, Segui, Miguel Angel, Meisner, Christoph, Loibl, Sibylle, Nekljudova, Valentina, Thomssen, Christoph, Von Minckwitz, Gunter, Kümmel, Sherko, Lopez, Massimo, Vici, Patrizia, Fountzilas, George, Koliou, Georgia, Mavroudis, Dimitrios, Saloustros, Emmanouil, Brain, Etienne, Delaloge, Suzette, Michiels, Stefan, Mathoulin-Pelissier, Simone, Bines, Jose, Sarmento, Roberta M B, Bonadonna, Gianni, Brambilla, Cristina, Rossi, Anna, Bliss, Judith, Coombes, Raoul Charles, Kilburn, Lucy, Marty, Michel, Amadori, Dino, Boccardo, Francesco, Nanni, Oriana, Rubagotti, Alessandra, Scarpi, Emanuela, Masuda, Norikazu, Toi, Masakazu, Ueno, Takayuki, Ishikawa, Takashi, Matsumoto, Koji, Takao, Shintaro, Sommer, Harald, Foroglou, Pericles, Giokas, George, Kondylis, D, Lissaios, Byron, Reinisch, Mattea, Lee, Keun Seok, Nam, Byung-Ho, Ro, Jung Sil, De Matteis, Andrea, Perrone, Francesco, Tang, Gong, Wolmark, Norman, Hozumi, Yasuo, Nomura, Yasuo, Earl, Helena, Hiller, Louise, Vallier, Anne-Laure, De Mastro, Lucia, Venturini, Macro, Delozier, Thierry, Lemonnier, Jerome, Martin, Anne-Laure, Roché, Henri, Spielmann, Marc, Chen, Xiasong, Shen, Kunwei, Albain, Kathy, Barlow, William, Budd, George T, Gralow, Julie, Hayes, Dan, Bartlett-Lee, Peter, Ellis, Paul, Bianco, Angelo Raffaele, De Laurentiis, Michelino, De Placido, Sabino, Wildiers, Hans, Hsu, Limin, Eremin, Oleg, Walker, Leslie G, Ahlgren, Johan, Blomqvist, Carl, Holmberg, Lars, Lindman, Henrik, Asmar, Lina, Jones, Stephen E, Gluz, Oleg, Liedtke, Cornelia, Arriagada, Rodrigo, Bergsten-Nordström, Elizabeth, Carey, Lisa, Coleman, Robert, Cuzick, Jack, Davidson, Nancy, Dignam, James, Dowsett, Mitch, Francis, Prudence A, Goetz, Matthew P, Goodwin, Pam, Halpin-Murphy, Pat, Hill, Catherine, Jagsi, Reshma, Mukai, Hirofumi, Ohashi, Yasuo, Pierce, Lori, Poortmans, Philip, Raina, Vinod, Rea, Daniel, Robertson, John, Rutgers, Emiel, Salgado, Roberto, Spanic, Tanja, Tutt, Andrew, Viale, Giuseppe, Wang, Xiang, Whelan, Tim, Wilcken, Nicholas, Cameron, David, Bergh, Jonas, and Swain, Sandra M

Published
2023
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17. The SURVIVE study: Liquid biopsy guided surveillance after intermediate- to high-risk early breast cancer.

Author

Pfister, Kerstin, primary, Huesmann, Sophia, additional, Friedl, Thomas W. P., additional, Fink, Angelina, additional, Mehmeti, Forca, additional, Mergel, Franziska, additional, Schäffler, Henning, additional, Heublein, Sabine, additional, Hartkopf, Andreas Daniel, additional, Mueller, Volkmar, additional, Wiesmueller, Lisa Maria, additional, Fehm, Tanja N., additional, Pantel, Klaus, additional, Rack, Brigitte, additional, and Janni, Wolfgang, additional

Published
2024
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18. The impact of anthracyclines in intermediate and high-risk HER2-negative early breast cancer—a pooled analysis of the randomised clinical trials PlanB and SUCCESS C

Author

de Gregorio, Amelie, Janni, Wolfgang, Friedl, Thomas W. P., Nitz, Ulrike, Rack, Brigitte, Schneeweiss, Andreas, Kates, Ronald, Fehm, Tanja, Kreipe, Hans, Christgen, Matthias, Kümmel, Sherko, Trapp, Elisabeth, Wuerstlein, Rachel, Hartkopf, Andreas, Clemens, Michael, Reimer, Toralf, Häberle, Lothar, Fasching, Peter A., Gluz, Oleg, and Harbeck, Nadia

Published
2022
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22. Harnessing the power of tidal flat diatoms to combat climate change.

Author

Park, Jihae, Lee, Hojun, Asselman, Jana, Janssen, Colin, Depuydt, Stephen, De Saeger, Jonas, Friedl, Thomas, Sabbe, Koen, Vyverman, Wim, Philippart, Catharina J. M., Pitarch, Jaime, Heynderickx, Philippe M., Wu, Di, Ronsse, Frederik, De Neve, Wesley, Pandey, Lalit K., Park, Joon Tae, and Han, Taejun

Subjects
GREENHOUSE gases, CARBON sequestration, CLIMATE change mitigation, SURFACE of the earth, MARINE biomass, COASTAL wetlands, TIDAL flats
Abstract

In approximately one decade, global temperatures will likely exceed a warming level that a United Nations Intergovernmental Panel on Climate Change report considers a "red alert for humanity". We propose exploring tidal flat diatoms to address climate change challenges. Tidal flats are extensive coastal ecosystems crucial to the provisioning and regulation of aquatic environments. Diatoms contribute to tidal flat biomass production and account for 20% of global primary productivity and 40% of annual marine biomass production, making them crucial for nutrient cycling and sediment stabilization. Potential CO2 removal from Korean tidal flats by diatoms is estimated to be 598,457–683,171 t CO2 equivalents (CO2e) annually, with the economic value of blue carbon (BC) resulting from diatom activity being approximately US$ 17.95–20.50 million. Dissemination of this potential could incentivize coastal wetland protection and climate change mitigation measures. The global estimated CO2e removal potential of tidal flat diatoms is 40,957,346–46,754,961 t CO2e, representing 0.11–0.13% of the annual global greenhouse gas emissions, even though tidal flats cover 0.0025% of the Earth's surface and diatoms represent less than 0.5% (by weight) of all photosynthetic plants. Researchers should combine ecology and economics to develop standardized approaches for carbon input monitoring and quantification. Further, spatiotemporal analyses of environmental threats to tidal flat diatoms are necessary for conserving their biodiversity and function as a critical BC source. Land-based cultivation for large-scale biomass production and biorefinery processes can contribute to a greener, more prosperous future for humanity and the marine ecosystems upon which we rely. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Impact of Granulocyte Colony-Stimulating Factor (G-CSF) and Epoetin (EPO) on Hematologic Toxicities and Quality of Life in Patients During Adjuvant Chemotherapy in Early Breast Cancer: Results From the Multi-Center Randomized ADEBAR Trial

Author

Bekes, Inga, Eichler, Martin, Singer, Susanne, Friedl, Thomas W.P., Harbeck, Nadia, Rack, Brigitte, Forstbauer, Helmut, Dannecker, Christian, Huober, Jens, Kiechle, Marion, Lato, Krisztian, Janni, Wolfgang, and Fink, Visnja

Published
2020
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29. Feasibility of a large multi-center translational research project for newly diagnosed breast and ovarian cancer patients with affiliated biobank: the BRandO biology and outcome (BiO)-project

Author

De Gregorio, Amelie, Nagel, Gabriele, Möller, Peter, Rempen, Andreas, Schlicht, Erik, Fritz, Steffen, Flock, Felix, Kühn, Thorsten, Thiel, Falk, Felberbaum, Ricardo, Ebner, Florian, De Gregorio, Nikolaus, Friedl, Thomas Wolfram Paul, Wiesmüller, Lisa, Kuhn, Peter, Schmitt, Margit, Janni, Wolfgang, Rothenbacher, Dietrich, and Huober, Jens

Published
2020
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30. Differential prognostic relevance of patho-anatomical factors among different tumor-biological subsets of breast cancer: Results from the adjuvant SUCCESS A study

Author

Deniz, Miriam, DeGregorio, Amelie, DeGregorio, Nikolaus, Bekes, Inga, Widschwendter, Peter, Schochter, Fabienne, Ernst, Kristina, Scholz, Christoph, Bauer, Emanuel CA., Aivazova-Fuchs, Viktoria, Weissenbacher, Tobias, Kost, Bernd, Jueckstock, Julia, Andergassen, Ullrich, Steidl, Julia, Trapp, Elisabeth, Fasching, Peter A., Häberle, Lothar, Beckmann, Matthias W., Schneeweiss, Andreas, Schrader, Iris, Janni, Wolfgang, Rack, Brigitte, and Friedl, Thomas WP.

Published
2019
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31. Use of Granulocyte-colony Stimulating Factor During Chemotherapy and Its Association With CA27.29 and Circulating Tumor Cells—Results From the SUCCESS A Trial

Author

Hepp, Philip, Fasching, Peter A., Beckmann, Matthias W., Fehm, Tanja, Salmen, Jessica, Hagenbeck, Carsten, Jäger, Bernadette, Widschwendter, Peter, de Gregorio, Nikolaus, Schochter, Fabienne, Mahner, Sven, Harbeck, Nadia, Weissenbacher, Tobias, Kurt, Ayse-Gül, Friedl, Thomas W.P., Janni, Wolfgang, and Rack, Brigitte

Published
2018
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32. Efficacy of Lapatinib in Patients with HER2-Negative Metastatic Breast Cancer and HER2-Positive Circulating Tumor Cells—The DETECT III Clinical Trial.

Author

Fehm, Tanja, Mueller, Volkmar, Banys-Paluchowski, Maggie, Fasching, Peter A, Friedl, Thomas W P, Hartkopf, Andreas, Huober, Jens, Loehberg, Christian, Rack, Brigitte, Riethdorf, Sabine, Schneeweiss, Andreas, Wallwiener, Diethelm, Meier-Stiegen, Franziska, Krawczyk, Natalia, Jaeger, Bernadette, Reinhardt, Florian, Hoffmann, Oliver, Mueller, Lothar, Wimberger, Pauline, and Ruckhaeberle, Eugen

Published
2024
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33. Congruence of chloroplast- and nuclear-encoded DNA sequence variations used to assess species boundaries in the soil microalga Heterococcus(Stramenopiles, Xanthophyceae)

Author

Rybalka, Nataliya, Wolf, Matthias, Andersen, Robert A, and Friedl, Thomas

Subjects
Biological Sciences, Ecology, Evolutionary Biology, Genetics, Antarctic Regions, Cell Nucleus, DNA, Algal, DNA, Chloroplast, DNA, Ribosomal Spacer, Evolution, Molecular, Genetic Markers, Likelihood Functions, Nucleic Acid Conformation, Phylogeny, Sequence Analysis, DNA, Soil, Stramenopiles, Evolutionary biology
Abstract

BackgroundHeterococcus is a microalgal genus of Xanthophyceae (Stramenopiles) that is common and widespread in soils, especially from cold regions. Species are characterized by extensively branched filaments produced when grown on agarized culture medium. Despite the large number of species described exclusively using light microscopic morphology, the assessment of species diversity is hampered by extensive morphological plasticity.ResultsTwo independent types of molecular data, the chloroplast-encoded psbA/rbcL spacer complemented by rbcL gene and the internal transcribed spacer 2 of the nuclear rDNA cistron (ITS2), congruently recovered a robust phylogenetic structure. With ITS2 considerable sequence and secondary structure divergence existed among the eight species, but a combined sequence and secondary structure phylogenetic analysis confined to helix II of ITS2 corroborated relationships as inferred from the rbcL gene phylogeny. Intra-genomic divergence of ITS2 sequences was revealed in many strains. The 'monophyletic species concept', appropriate for microalgae without known sexual reproduction, revealed eight different species. Species boundaries established using the molecular-based monophyletic species concept were more conservative than the traditional morphological species concept. Within a species, almost identical chloroplast marker sequences (genotypes) were repeatedly recovered from strains of different origins. At least two species had widespread geographical distributions; however, within a given species, genotypes recovered from Antarctic strains were distinct from those in temperate habitats. Furthermore, the sequence diversity may correspond to adaptation to different types of habitats or climates.ConclusionsWe established a method and a reference data base for the unambiguous identification of species of the common soil microalgal genus Heterococcus which uses DNA sequence variation in markers from plastid and nuclear genomes. The molecular data were more reliable and more conservative than morphological data.

Published
2013

34. Prognostic Impact of Weight Change During Adjuvant Chemotherapy in Patients With High-Risk Early Breast Cancer: Results From the ADEBAR Study

Author

Mutschler, Nikola S., Scholz, Christoph, Friedl, Thomas W.P., Zwingers, Thomas, Fasching, Peter A., Beckmann, Matthias W., Fehm, Tanja, Mohrmann, Svjetlana, Salmen, Jessica, Ziegler, Carola, Jäger, Bernadette, Widschwendter, Peter, de Gregorio, Nikolaus, Schochter, Fabienne, Mahner, Sven, Harbeck, Nadia, Weissenbacher, Tobias, Jückstock, Julia, Janni, Wolfgang, and Rack, Brigitte

Published
2018
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35. Congruence of chloroplast- and nuclear-encoded DNA sequence variations used to assess species boundaries in the soil microalga Heterococcus (Stramenopiles, Xanthophyceae).

Author

Rybalka, Nataliya, Wolf, Matthias, Andersen, Robert A, and Friedl, Thomas

Subjects
Cell Nucleus, DNA, Algal, DNA, Chloroplast, DNA, Ribosomal Spacer, Soil, Genetic Markers, Likelihood Functions, Sequence Analysis, DNA, Evolution, Molecular, Phylogeny, Nucleic Acid Conformation, Antarctic Regions, Stramenopiles, Genetics, Evolutionary Biology
Abstract

BackgroundHeterococcus is a microalgal genus of Xanthophyceae (Stramenopiles) that is common and widespread in soils, especially from cold regions. Species are characterized by extensively branched filaments produced when grown on agarized culture medium. Despite the large number of species described exclusively using light microscopic morphology, the assessment of species diversity is hampered by extensive morphological plasticity.ResultsTwo independent types of molecular data, the chloroplast-encoded psbA/rbcL spacer complemented by rbcL gene and the internal transcribed spacer 2 of the nuclear rDNA cistron (ITS2), congruently recovered a robust phylogenetic structure. With ITS2 considerable sequence and secondary structure divergence existed among the eight species, but a combined sequence and secondary structure phylogenetic analysis confined to helix II of ITS2 corroborated relationships as inferred from the rbcL gene phylogeny. Intra-genomic divergence of ITS2 sequences was revealed in many strains. The 'monophyletic species concept', appropriate for microalgae without known sexual reproduction, revealed eight different species. Species boundaries established using the molecular-based monophyletic species concept were more conservative than the traditional morphological species concept. Within a species, almost identical chloroplast marker sequences (genotypes) were repeatedly recovered from strains of different origins. At least two species had widespread geographical distributions; however, within a given species, genotypes recovered from Antarctic strains were distinct from those in temperate habitats. Furthermore, the sequence diversity may correspond to adaptation to different types of habitats or climates.ConclusionsWe established a method and a reference data base for the unambiguous identification of species of the common soil microalgal genus Heterococcus which uses DNA sequence variation in markers from plastid and nuclear genomes. The molecular data were more reliable and more conservative than morphological data.

Published
2013

38. Gemcitabine as adjuvant chemotherapy in patients with high-risk early breast cancer—results from the randomized phase III SUCCESS-A trial

Author

de Gregorio, Amelie, Häberle, Lothar, Fasching, Peter A., Müller, Volkmar, Schrader, Iris, Lorenz, Ralf, Forstbauer, Helmut, Friedl, Thomas W. P., Bauer, Emanuel, de Gregorio, Nikolaus, Deniz, Miriam, Fink, Visnja, Bekes, Inga, Andergassen, Ulrich, Schneeweiss, Andreas, Tesch, Hans, Mahner, Sven, Brucker, Sara Y., Blohmer, Jens-Uwe, Fehm, Tanja N., Heinrich, Georg, Lato, Krisztian, Beckmann, Matthias W., Rack, Brigitte, and Janni, Wolfgang

Published
2020
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43. Cyanobacteria and Algae of Biological Soil Crusts

Author

Büdel, Burkhard, Dulić, Tamara, Darienko, Tatyana, Rybalka, Nataliya, Friedl, Thomas, Caldwell, Martyn M., Series editor, Díaz, Sandra, Series editor, Heldmaier, Gerhard, Series editor, Jackson, Robert B., Series editor, Lange, Otto L., Series editor, Levia, Delphis F., Series editor, Mooney, Harold A., Series editor, Schulze, Ernst-Detlef, Series editor, Sommer, Ulrich, Series editor, Weber, Bettina, editor, Büdel, Burkhard, editor, and Belnap, Jayne, editor

Published
2016
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44. Prevalence of Circulating Tumor Cells After Adjuvant Chemotherapy With or Without Anthracyclines in Patients With HER2-negative, Hormone Receptor-positive Early Breast Cancer

Author

Schramm, Amelie, Schochter, Fabienne, Friedl, Thomas W.P., de Gregorio, Nikolaus, Andergassen, Ulrich, Alunni-Fabbroni, Marianna, Trapp, Elisabeth, Jaeger, Bernadette, Heinrich, Georg, Camara, Oumar, Decker, Thomas, Ober, Angelika, Mahner, Sven, Fehm, Tanja N., Pantel, Klaus, Fasching, Peter A., Schneeweiss, Andreas, Janni, Wolfgang, and Rack, Brigitte K.

Published
2017
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47. Supplementary Figure S2A from Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer

Author

Janni, Wolfgang J., primary, Rack, Brigitte, primary, Terstappen, Leon W.M.M., primary, Pierga, Jean-Yves, primary, Taran, Florin-Andrei, primary, Fehm, Tanja, primary, Hall, Carolyn, primary, de Groot, Marco R., primary, Bidard, François-Clement, primary, Friedl, Thomas W.P., primary, Fasching, Peter A., primary, Brucker, Sara Y., primary, Pantel, Klaus, primary, and Lucci, Anthony, primary

Published
2023
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48. Supplementary Table S1 from Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer

Author

Janni, Wolfgang J., primary, Rack, Brigitte, primary, Terstappen, Leon W.M.M., primary, Pierga, Jean-Yves, primary, Taran, Florin-Andrei, primary, Fehm, Tanja, primary, Hall, Carolyn, primary, de Groot, Marco R., primary, Bidard, François-Clement, primary, Friedl, Thomas W.P., primary, Fasching, Peter A., primary, Brucker, Sara Y., primary, Pantel, Klaus, primary, and Lucci, Anthony, primary

Published
2023
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49. supplemental figure legend from Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer

Author

Janni, Wolfgang J., primary, Rack, Brigitte, primary, Terstappen, Leon W.M.M., primary, Pierga, Jean-Yves, primary, Taran, Florin-Andrei, primary, Fehm, Tanja, primary, Hall, Carolyn, primary, de Groot, Marco R., primary, Bidard, François-Clement, primary, Friedl, Thomas W.P., primary, Fasching, Peter A., primary, Brucker, Sara Y., primary, Pantel, Klaus, primary, and Lucci, Anthony, primary

Published
2023
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50. Abstract PD18-07: Omission of chemotherapy in the treatment of HER2-positive and hormone-receptor positive metastatic breast cancer – interim results from the randomized phase 3 DETECT V trial

Author

Janni, Wolfgang, primary, Fehm, Tanja, additional, Müller, Volkmar, additional, Schochter, Fabienne, additional, De Gregorio, Amelie, additional, Decker, Thomas, additional, Hartkopf, Andreas, additional, Just, Marianne, additional, Sagasser, Jacqueline, additional, Schmidt, Marcus, additional, Wimberger, Pauline, additional, Banys-Paluchowski, Maggie, additional, Fasching, Peter A., additional, Rack, Brigitte, additional, Riethdorf, Sabine, additional, Schneeweiss, Andreas, additional, Wallwiener, Diethelm, additional, Meier-Stiegen, Franziska, additional, Krawczyk, Natalia, additional, Hoffmann, Oliver, additional, Blohmer, Jens-Uwe, additional, Niederacher, Dieter, additional, Neubauer, Hans, additional, Pantel, Klaus, additional, Friedl, Thomas W., additional, and Huober, Jens, additional

Published
2023
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