33 results on '"Fritzsche, F R"'
Search Results
2. Flache epitheliale Atypie und andere Zylinderzellläsionen der Brust
- Author
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Fritzsche, F. R., Dietel, M., and Kristiansen, G.
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- 2006
- Full Text
- View/download PDF
3. Influence of drinking habits of pathologists on publications
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Fritzsche, F R and Kristiansen, G
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- 2009
- Full Text
- View/download PDF
4. European and US publications in the 50 highest ranking pathology journals from 2000 to 2006
- Author
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Fritzsche, F R, Oelrich, B, Dietel, M, Jung, K, and Kristiansen, G
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- 2008
- Full Text
- View/download PDF
5. Radiological and pathological findings of a metastatic composite paraganglioma with neuroblastoma in a man: a case report
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Fritzsche, F R, Bode, P K, Koch, S, Frauenfelder, T, University of Zurich, and Fritzsche, F R
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10042 Clinic for Diagnostic and Interventional Radiology ,10049 Institute of Pathology and Molecular Pathology ,610 Medicine & health ,2700 General Medicine - Published
- 2010
- Full Text
- View/download PDF
6. Expression of Histone Deacetylases 1, 2 and 3 in histological subtypes of testicular germ cell tumours
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Fritzsche, F R, Hasler, A, Bode, P K, Adams, H, Seifert, H H, Sulser, T, Moch, H, Barghorn, A, Kristiansen, G, and University of Zurich
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2734 Pathology and Forensic Medicine ,10062 Urological Clinic ,616 - Patología. Medicina clínica. Oncología ,10022 Division of Surgical Research ,HDAC ,10049 Institute of Pathology and Molecular Pathology ,610 Medicine & health ,2722 Histology ,Immunohistochemistry - Abstract
In this study we aimed to evaluate the protein expression of class I histone deacetylases (HDAC) in testicular germ cell tumours (GCT) and to analyse differences between the histological subtypes of testicular GCT. 325 testicular GCT were included in a tissue microarray with each histological subtype of the tumour being separately represented on this array. Expression of class I HDAC isoforms 1, 2 and 3 was assessed by immunohistochemistry. While HDAC2 and 3 were highly expressed in all histological subtypes of GCT, HDAC1 was almost consistently expressed at lower levels. We observed significant differences in the expression of the respective HDACs between seminoma and non-seminoma GCT tissue components. Interestingly, choriocarcinomas showed generally high expression values for all three class I HDAC isoforms. Relevant correlations with clinicopathological parameters could not be demonstrated. Contrasting published findings on other tumour entities, no immediate practical diagnostic or prognostic value for HDAC1-3 in GCT could be inferred. However, the high expression levels might still be indicative for a treatment response to HDAC inhibitors which ought to be evaluated in further studies.
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- 2011
7. MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors
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Bode, P K, Barghorn, A, Fritzsche, F R, Riener, M O, Kristiansen, G, Knuth, A, Moch, H, and University of Zurich
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2734 Pathology and Forensic Medicine ,10049 Institute of Pathology and Molecular Pathology ,610 Medicine & health - Published
- 2011
- Full Text
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8. Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx
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Huber, G F, Fritzsche, F R, et al, University of Zurich, and Huber, G F
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10049 Institute of Pathology and Molecular Pathology ,610 Medicine & health ,10045 Clinic for Otorhinolaryngology ,2730 Oncology ,1306 Cancer Research - Published
- 2011
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9. Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas
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Riener, M O, Fritzsche, F R, Soll, C, Pestalozzi, B C, Probst-Hensch, N M, Clavien, P A, Jochum, W, Soltermann, A, Moch, H, Kristiansen, G, University of Zurich, and Kristiansen, G
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2734 Pathology and Forensic Medicine ,10049 Institute of Pathology and Molecular Pathology ,610 Medicine & health ,2722 Histology - Published
- 2010
10. Determination of the Her-2/neu gene amplification status in cytologic breast cancer specimens using automated silver-enhanced in-situ hybridization (SISH)
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Fritzsche, F R, Bode, P K, Moch, H, Kristiansen, G, Varga, Z, Bode, B, and University of Zurich
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2734 Pathology and Forensic Medicine ,10049 Institute of Pathology and Molecular Pathology ,610 Medicine & health ,2702 Anatomy ,2746 Surgery - Published
- 2010
11. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
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Weichert, W, Röske, A, Gekeler, V, Beckers, T, Stephan, C, Jung, K, Fritzsche, F R, Niesporek, S, Denkert, C, Dietel, M, Kristiansen, G, University of Zurich, and Kristiansen, G
- Subjects
10049 Institute of Pathology and Molecular Pathology ,610 Medicine & health ,2730 Oncology ,1306 Cancer Research - Published
- 2008
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12. Silver-enhanced in situ hybridization for detection of polyomavirus DNA in patients with BK virus nephropathy
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Fritzsche, F R, Pianca, S, Gaspert, A, Varga, Z, Wang, L, Farrell, M P, Chen, X B, Hirsch, H H, Springer, E, Fehr, T, Myles, J, Tubbs, R, Moch, H, Fritzsche, F R, Pianca, S, Gaspert, A, Varga, Z, Wang, L, Farrell, M P, Chen, X B, Hirsch, H H, Springer, E, Fehr, T, Myles, J, Tubbs, R, and Moch, H
- Abstract
BK virus nephropathy is not an infrequent complication of renal transplantation associated with high rates of graft loss. Although antibodies against SV40 antigen detect different viruses of the polyomavirus family, immunohistochemistry is widely used to confirm the diagnosis of BK virus nephropathy in renal biopsies. Here we aimed to validate the novel silver-enhanced in situ hybridization (SISH) technique for the automated detection of BK virus in renal transplant biopsies. Two different patient cohorts were included. Twenty-nine consecutive patients suspicious for BK virus infection were investigated by SISH and chromogenic in situ hybridization. An additional 26 renal biopsies positive by SV40 immunohistochemistry from 19 patients were analyzed by SISH. Polyomavirus DNA serum levels, as determined by nested PCR analysis, were available for all of these patients. The presence of BK virus DNA in renal tubular cells was identified in 5 of the suspicious cases by both, SISH and chromogenic in situ hybridization . One additional patient was only positive in the SISH. In the second cohort, SISH was positive in all SV40 positive biopsies, but SISH signals were less extensive than SV40 immunohistochemistry. Our results show that the BK virus SISH is an ancillary tool for the detection of polyomavirus DNA in renal biopsies using bright-field microscopy. However, its diagnostic value in comparison with standard immunohistochemistry seems to be limited.
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- 2011
13. Pathological processing techniques and final diagnosis of breast cancer sentinel lymph nodes
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Fritzsche, F R, Reineke, T, Morawietz, L, Kristiansen, G, Dietel, M, Fink, D, Rageth, C, Honegger, C, Caduff, R, Moch, H, Varga, Z, Fritzsche, F R, Reineke, T, Morawietz, L, Kristiansen, G, Dietel, M, Fink, D, Rageth, C, Honegger, C, Caduff, R, Moch, H, and Varga, Z
- Abstract
BACKGROUND: Recommendations for intraoperative and postoperative breast sentinel lymph node (SLN) processing differ widely. Micrometastases and isolated tumor cells (ITC) have recently been proposed as prognostically and therapeutically relevant. We compared 3 SLN protocols with regard to intraoperative and postoperative diagnosis. MATERIALS AND METHODS: SLN in cohort I (270 patients) were intraoperatively assessed by stereomicroscopy. Intraoperative frozen section (IFS) was used only in stereomicroscopically suspicious SLN. In cohort II (197 patients), all SLN were examined with only 1 IFS. Final SLN workup in cohorts I and II consisted of complete step sectioning with immunohistochemistry. In cohort III (268 patients) 2 or more IFS were performed followed by 3 step sections and immunohistochemistry. RESULTS: pN1 stages were significantly higher in cohorts I and II (33.3% and 34.0% respectively) than in cohort III (24.6%). Intraoperative false negativity for the detection of metastases (pN1) ranged from 54.4% (cohort I) and 35.8% (cohort II) to 21.2% (cohort III). In contrast, ITC were detected significantly more frequently in cohort I (9.3%) and cohort II (14.7%) than in cohort III (1.9%). CONCLUSIONS: Higher rates of SLN metastases and ITC in cohort I/II compared to cohort III suggest that IFS may result in tissue loss thus increasing the risk of missing metastases. Sparse IFS but complete postoperative SLN workup with step sectioning and immunohistochemistry provides more accurate information regarding minimal disease in SLN, but often results in delayed axillary lymph node dissection. This is important for preoperative patient information and recommendations in SLN processing protocols.
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- 2010
14. Pulmonary Kaposi's sarcoma after heart transplantation: a case report
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Fritzsche, F R, Tutic, M, Opitz, I, Hunziker, R, Kristiansen, G, Montani, M, Fritzsche, F R, Tutic, M, Opitz, I, Hunziker, R, Kristiansen, G, and Montani, M
- Abstract
INTRODUCTION: Kaposi's sarcomas have been associated with different conditions of immunosuppression and are also known to be a typical complication of solid organ transplantations. CASE PRESENTATION: We report of a 65 year old man of Turkish origin with a history of heart transplantation 10 months ago who presented for clarification of his dyspnoea. The patient had a known history of chronic obstructive pulmonary disease and a smoking history of 40 pack years. Radiologically, three progressively growing intrapulmonary nodules were detected. The histology was diagnostic for a Kaposi's sarcoma. Visceral and especially primary intrapulmonary Kaposi's sarcomas are very rare and have been described to have a rather unfavourable prognosis. CONCLUSION: Even with a history suggestive for conventional lung cancer, Kaposi's sarcomas should be considered in patients after transplantation of solid organs. It should be noticed that in a minority of cases this tumour exists in the absence of the typical cutaneous lesions.
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- 2010
15. Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores
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Ikenberg, K, Fritzsche, F R, Zuerrer-Haerdi, U, Hofmann, I, Hermanns, T, Seifert, H, Müntener, M, Provenzano, M; https://orcid.org/0000-0001-6993-5718, Sulser, T, Behnke, S, Gerhardt, J, Mortezavi, A, Wild, P, Hofstädter, F, Burger, M, Moch, H, Kristiansen, G, Ikenberg, K, Fritzsche, F R, Zuerrer-Haerdi, U, Hofmann, I, Hermanns, T, Seifert, H, Müntener, M, Provenzano, M; https://orcid.org/0000-0001-6993-5718, Sulser, T, Behnke, S, Gerhardt, J, Mortezavi, A, Wild, P, Hofstädter, F, Burger, M, Moch, H, and Kristiansen, G
- Abstract
BACKGROUND: The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. METHODS: Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA) organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC). IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. RESULTS: IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p < 0.0001), but did not show significant correlation with the pT-stage, the proliferation index (MIB1), preoperative serum PSA level and the margin status. Only a weak and slightly significant correlation was found with the Gleason score and IMP3 expression failed to show prognostic significance in clinico-pathological correlation-analyses. CONCLUSIONS: Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed.
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- 2010
16. Periostin is up-regulated in high grade and high stage prostate cancer
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Tischler, V, Fritzsche, F R, Wild, P J, Stephan, C, Seifert, H H, Riener, M O, Hermanns, T, Mortezavi, A, Gerhardt, J, Schraml, P, Jung, K, Moch, H, Soltermann, A, Kristiansen, G, Tischler, V, Fritzsche, F R, Wild, P J, Stephan, C, Seifert, H H, Riener, M O, Hermanns, T, Mortezavi, A, Gerhardt, J, Schraml, P, Jung, K, Moch, H, Soltermann, A, and Kristiansen, G
- Abstract
BACKGROUND: Expression of periostin is an indicator of epithelial-mesenchymal transition in cancer but a detailed analysis of periostin expression in prostate cancer has not been conducted so far. METHODS: Here, we evaluated periostin expression in prostate cancer cells and peritumoural stroma immunohistochemically in two independent prostate cancer cohorts, including a training cohort (n = 93) and a test cohort (n = 325). Metastatic prostate cancers (n = 20), hormone refractory prostate cancers (n = 19) and benign prostatic tissues (n = 38) were also analyzed. RESULTS: In total, strong epithelial periostin expression was detectable in 142 of 418 (34.0%) of prostate carcinomas and in 11 of 38 benign prostate glands (28.9%). Increased periostin expression in carcinoma cells was significantly associated with high Gleason score (p < 0.01) and advanced tumour stage (p < 0.05) in the test cohort. Whereas periostin expression was weak or absent in the stroma around normal prostate glands, strong periostin expression in tumour stroma was found in most primary and metastatic prostate cancers. High stromal periostin expression was associated with higher Gleason scores (p < 0.001). There was a relationship between stromal periostin expression and shortened PSA relapse free survival times in the training cohort (p < 0.05). CONCLUSIONS: Our data indicate that periostin up-regulation is related to increased tumour aggressiveness in prostate cancer and might be a promising target for therapeutical interventions in primary and metastatic prostate cancer.
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- 2010
17. GOLPH2 expression may serve as diagnostic marker in seminomas
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Fritzsche, F R, Kristiansen, G, Riener, M-O, Dietel, M, Oelrich, B, Fritzsche, F R, Kristiansen, G, Riener, M-O, Dietel, M, and Oelrich, B
- Abstract
BACKGROUND: GOLPH2 (Golgi phosphoprotein 2) is a novel Golgi membrane protein. Despite its unknown physiologic function, however, it has been proposed as a biomarker for hepatocellular and prostate carcinoma due to its upregulation in those cancer entities. Whether the overexpression of GOLPH2 is tumour specific or a generic parameter of malignancy and whether this finding is true for additional carcinomas has not been determined. In this study, we aimed to evaluate the expression pattern of GOLPH2 in testicular seminomas, the most common histologic subtype of testicular neoplasm. METHODS: GOLPH2 protein expression was assessed by immunohistochemistry in 69 testicular seminomas and compared to the expression rates in matching normal testicular tissue and intratubular germ cell neoplasia of unclassified type (IGCNU). In addition, a subset of Leydig cell tumours was analyzed accordingly. RESULTS: GOLPH2 was consistently overexpressed (89.9%) in seminomas. Matching non-neoplastic tissue showed weak or negative staining. The observed differences between non-neoplastic and neoplastic tissue were statistically highly significant (p < 0.001). There were no significant associations with tumour status. Interestingly, GOLPH2 was also highly expressed in the intertubular Leydig cells as well as in Leydig cell tumours. CONCLUSIONS: GOLPH2 protein is highly expressed in seminomas and in Leydig cell tumours. This study fosters the association of GOLPH2 with malignant neoplastic processes. The staining pattern is easily assessable and consistent which is a favourable property especially in clinical settings. GOLPH2 could be a novel immunohistochemical marker for the assessment of testicular neoplasms, especially against the background that in analogy to hepatocellular carcinomas complementary GOLPH2 serum levels might be helpful in detecting metastases or recurrent tumour. Therefore serum studies and analyses of GOLPH2 expression in non-seminomatous germ cell tumours are
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- 2010
18. Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer
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Kempkensteffen, C, Fritzsche, F R, Johannsen, M, Weikert, S, Hinz, S, Dietel, M, Riener, M O, Moch, H, Jung, K, Krause, H, Miller, K, Kristiansen, G, Kempkensteffen, C, Fritzsche, F R, Johannsen, M, Weikert, S, Hinz, S, Dietel, M, Riener, M O, Moch, H, Jung, K, Krause, H, Miller, K, and Kristiansen, G
- Abstract
BACKGROUND: Decreased expression of the interferon-stimulated, putative tumour suppressor gene XAF1 has been shown to play a role during the onset, progression and treatment failure in various malignancies. However, little is yet known about its potential implication in the tumour biology of clear-cell renal cell cancer (ccRCC). METHODS: This study assessed the expression of XAF1 protein in tumour tissue obtained from 291 ccRCC patients and 68 normal renal tissue samples, utilizing immunohistochemistry on a tissue-micro-array. XAF1 expression was correlated to clinico-pathological tumour features and prognosis. RESULTS: Nuclear XAF1 expression was commonly detected in normal renal- (94.1%) and ccRCC (91.8%) samples, without significant differences of expression levels. Low XAF1 expression in ccRCC tissue, however, was associated with progression of tumour stage (p = 0.040) and grade (p < 0.001). Low XAF1 tumour levels were also prognostic of significantly shortened overall survival times in univariate analysis (p = 0.018), but did not provide independent prognostic information. CONCLUSION: These data suggest down-regulation of XAF1 expression to be implicated in ccRCC progression and implies that its re-induction may provide a therapeutic approach. Although the prognostic value of XAF1 in ccRCC appears to be limited, its predictive value remains to be determined, especially in patients with metastatic disease undergoing novel combination therapies of targeted agents with Interferon-alpha.
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- 2009
19. Large mixed germ cell tumor in a young patient presenting as an intrapulmonary mass
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Fritzsche, F R, Kristiansen, G, Frauenfelder, T, Opitz, I, Bode, P, Moch, H, Montani, M, Fritzsche, F R, Kristiansen, G, Frauenfelder, T, Opitz, I, Bode, P, Moch, H, and Montani, M
- Abstract
We present the case of a 26-year-old man with a bland medical history, who presented to the general practitioner because of severe cough and dyspnea. The chest X-ray revealed a massive organ-displacing tumor in the right chest not delineable from the mediastinum. The subsequent needle core biopsy was diagnostic for a mixed germ cell tumor comprising immature teratoma and seminoma. After an initially good response to chemotherapy, tumor markers and tumor size were progressive. The right-sided pneumonectomy revealed an intrapulmonary tumor with cystic and solid components, hemorrhage, and necrosis with a tumor diameter of 18cm. Histology confirmed a teratoma with mature and immature components accompanied by residual seminomatous tumor cells. Despite maximal intensive care, the patient died four weeks after surgery from acute respiratory distress syndrome. We describe this exceptional large intrapulmonary germ cell tumor and discuss the spectrum of such rare tumors.
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- 2009
20. GOLPH2 expression in renal cell cancer
- Author
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Fritzsche, F R, Riener, M O, Dietel, M, Moch, H, Jung, K, Kristiansen, G, Fritzsche, F R, Riener, M O, Dietel, M, Moch, H, Jung, K, and Kristiansen, G
- Abstract
BACKGROUND: Renal cell carcinomas (RCC) are among the most common and most lethal genitourinary malignancies. GOLPH2 (golgi phosphoprotein 2, GOLM1) has recently been proposed as a biomarker for hepatocellular and prostate cancer. In this study we analysed the expression patterns and the prognostic and diagnostic value of GOLPH2 in RCC. METHODS: GOLPH2 protein expression was analysed by immunohistochemistry in 104 clinically well characterized RCC cases in comparison with matched normal kidney tissue and in association with clinico-pathological parameters. Statistical analyses including Kaplan Meier analyses were performed with SPSS version 15.0. RESULTS: GOLPH2 was highly expressed in normal renal tubules and in almost half of RCC with a statistically significant predominance in the papillary and chromophobe histological subtypes. No other associations with clinico-pathological parameters were detectable. The Kaplan-Meier curves showed a weak trend for unfavourable prognosis of tumours with high GOLPH2 expression, but failed significance. CONCLUSION: GOLPH2 protein is expressed in normal renal tissue (especially in distal tubular epithelia) and is down-regulated in the majority of clear cell RCC. In papillary and chromophobe RCC GOLPH2 expression is consistently present. In contrast to its diagnostic value in hepatocellular and prostatic carcinomas, a prognostic or diagnostic value of GOLPH2 in RCC appears to be unlikely.
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- 2008
21. ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression
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Fritzsche, F R, Wassermann, K, Jung, M, Tölle, A, Kristiansen, I, Lein, M, Johannsen, M, Dietel, M, Jung, K, Kristiansen, G, Fritzsche, F R, Wassermann, K, Jung, M, Tölle, A, Kristiansen, I, Lein, M, Johannsen, M, Dietel, M, Jung, K, and Kristiansen, G
- Abstract
BACKGROUND: A Disintegrin And Metalloprotease (ADAM) 9 has been implicated in tumour progression of various solid tumours, however, little is known about its role in renal cell carcinoma. We evaluated the expression of ADAM9 on protein and transcript level in a clinico-pathologically characterized renal cell cancer cohort. METHODS: 108 renal cancer cases were immunostained for ADAM9 on a tissue-micro-array. For 30 additional cases, ADAM9 mRNA of microdissected tumour and normal tissue was analyzed via quantitative RT-PCR. SPSS 14.0 was used to apply crosstables (Fisher's exact test and chi2-test), correlations and univariate as well as multivariate survival analyses. RESULTS: ADAM9 was significantly up-regulated in renal cancer in comparison to the adjacent normal tissue on mRNA level. On protein level, ADAM9 was significantly associated with higher tumour grade, positive nodal status and distant metastasis. Furthermore, ADAM9 protein expression was significantly associated with shortened patient survival in the univariate analysis. CONCLUSION: ADAM9 is strongly expressed in a large proportion of renal cell cancers, concordant with findings in other tumour entities. Additionally, ADAM9 expression is significantly associated with markers of unfavourable prognosis. Whether the demonstrated prognostic value of ADAM9 is independent from other tumour parameters will have to be verified in larger study cohorts.
- Published
- 2008
22. Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype
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Kristiansen, G, primary, Rose, M, additional, Geisler, C, additional, Fritzsche, F R, additional, Gerhardt, J, additional, Lüke, C, additional, Ladhoff, A-M, additional, Knüchel, R, additional, Dietel, M, additional, Moch, H, additional, Varga, Z, additional, Theurillat, J-P, additional, Gorr, T A, additional, and Dahl, E, additional
- Published
- 2010
- Full Text
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23. GOLPH2 protein expression as a novel tissue biomarker for prostate cancer: implications for tissue-based diagnostics
- Author
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Kristiansen, G, primary, Fritzsche, F R, additional, Wassermann, K, additional, Jäger, C, additional, Tölle, A, additional, Lein, M, additional, Stephan, C, additional, Jung, K, additional, Pilarsky, C, additional, Dietel, M, additional, and Moch, H, additional
- Published
- 2008
- Full Text
- View/download PDF
24. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
- Author
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Weichert, W, primary, Röske, A, additional, Gekeler, V, additional, Beckers, T, additional, Stephan, C, additional, Jung, K, additional, Fritzsche, F R, additional, Niesporek, S, additional, Denkert, C, additional, Dietel, M, additional, and Kristiansen, G, additional
- Published
- 2008
- Full Text
- View/download PDF
25. European and US publications in the 50 highest ranking pathology journals from 2000 to 2006
- Author
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Fritzsche, F R, primary, Oelrich, B, additional, Dietel, M, additional, Jung, K, additional, and Kristiansen, G, additional
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- 2007
- Full Text
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26. Breast core biopsy | Mammastanzbiopsien
- Author
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Fritzsche, F. R., Ulrich Bick, Dietel, M., and Kristiansen, G.
27. Pulmonary Kaposi's sarcoma after heart transplantation: a case report
- Author
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Roger Hunziker, Glen Kristiansen, Matteo Montani, Michaela Tutic, Florian R. Fritzsche, Isabelle Opitz, University of Zurich, and Fritzsche, F R
- Subjects
Heart transplantation ,Medicine(all) ,medicine.medical_specialty ,Pathology ,business.industry ,10042 Clinic for Diagnostic and Interventional Radiology ,medicine.medical_treatment ,lcsh:R ,lcsh:Medicine ,Case Report ,Immunosuppression ,610 Medicine & health ,General Medicine ,2700 General Medicine ,medicine.disease ,Dermatology ,Transplantation ,Surgical oncology ,10049 Institute of Pathology and Molecular Pathology ,Medicine ,Sarcoma ,Complication ,business ,Lung cancer ,Pulmonary Kaposi's Sarcoma - Abstract
Introduction Kaposi's sarcomas have been associated with different conditions of immunosuppression and are also known to be a typical complication of solid organ transplantations. Case presentation We report the case of a 65-year-old Turkish man with a history of heart transplantation 10 months ago who presented for clarification of his dyspnea. The patient had a known history of chronic obstructive pulmonary disease and a smoking history of 40 pack years. Radiologically, three progressively growing intra-pulmonary nodules were detected. The histology was diagnostic for a Kaposi's sarcoma. Visceral and especially primary intra-pulmonary Kaposi's sarcomas are very rare and have been described to have a rather unfavorable prognosis. Conclusions Even with a history suggestive for conventional lung cancer, Kaposi's sarcomas should be considered in patients after transplantation of solid organs. It should be noted that in a minority of cases this tumor exists in the absence of the typical cutaneous lesions.
- Published
- 2010
28. Large mixed germ cell tumor in a young patient presenting as an intrapulmonary mass
- Author
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Matteo Montani, Isabelle Opitz, Florian R. Fritzsche, Peter K. Bode, Thomas Frauenfelder, Glen Kristiansen, Holger Moch, University of Zurich, and Fritzsche, F R
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Lung Neoplasms ,10255 Clinic for Thoracic Surgery ,medicine.medical_treatment ,610 Medicine & health ,Pathology and Forensic Medicine ,1307 Cell Biology ,Pneumonectomy ,Fatal Outcome ,Intensive care ,10049 Institute of Pathology and Molecular Pathology ,Biomarkers, Tumor ,Medicine ,Humans ,Chemotherapy ,business.industry ,10042 Clinic for Diagnostic and Interventional Radiology ,Teratoma ,Mediastinum ,Cell Biology ,Seminoma ,medicine.disease ,Combined Modality Therapy ,2734 Pathology and Forensic Medicine ,medicine.anatomical_structure ,Disease Progression ,Immature teratoma ,Radiography, Thoracic ,business ,Tomography, X-Ray Computed ,Germ cell - Abstract
We present the case of a 26-year-old man with a bland medical history, who presented to the general practitioner because of severe cough and dyspnea. The chest X-ray revealed a massive organ-displacing tumor in the right chest not delineable from the mediastinum. The subsequent needle core biopsy was diagnostic for a mixed germ cell tumor comprising immature teratoma and seminoma. After an initially good response to chemotherapy, tumor markers and tumor size were progressive. The right-sided pneumonectomy revealed an intrapulmonary tumor with cystic and solid components, hemorrhage, and necrosis with a tumor diameter of 18cm. Histology confirmed a teratoma with mature and immature components accompanied by residual seminomatous tumor cells. Despite maximal intensive care, the patient died four weeks after surgery from acute respiratory distress syndrome. We describe this exceptional large intrapulmonary germ cell tumor and discuss the spectrum of such rare tumors.
- Published
- 2009
- Full Text
- View/download PDF
29. Genomic profiling of late-onset basal cell carcinomas from two brothers with nevoid basal cell carcinoma syndrome.
- Author
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Hasan Ali O, Yurchenko AA, Pavlova O, Sartori A, Bomze D, Higgins R, Ring SS, Hartmann F, Bühler D, Fritzsche FR, Jochum W, Navarini AA, Kim A, French LE, Dermitzakis E, Christiano AM, Hohl D, Bickers DR, Nikolaev SI, and Flatz L
- Subjects
- Adult, Genomics, Humans, Male, Patched Receptors, Patched-1 Receptor genetics, Siblings, Basal Cell Nevus Syndrome genetics, Carcinoma, Basal Cell genetics, Skin Neoplasms genetics
- Abstract
Background: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant genetic disorder. It is commonly caused by mutations in PTCH1 and chiefly characterized by multiple basal cell carcinomas (BCCs) developing prior to the age of 30 years. In rare cases, NBCCS presents with a late onset of BCC development., Objective: To investigate BCC tumorigenesis in two brothers, who showed characteristic features of NBCCS but developed their first BCCs only after the age of 40 years. Two other siblings did not show signs of NBCCS., Results: We obtained blood samples from four siblings and nine BCCs from the two brothers with NBCCS. Whole exome sequencing and RNA sequencing revealed loss of heterozygosity (LOH) of PTCH1 in eight out of nine tumours that consistently involved the same haplotype on chromosome 9. This haplotype contained a germinal splice site mutation in PTCH1 (NM_001083605:exon9:c.763-6C>A). Analysis of germline DNA confirmed segregation of this mutation with the disease. All BCCs harboured additional somatic loss-of-function (LoF) mutations in the remaining PTCH1 allele which are not typically seen in other cases of NBCCS. This suggests a hypomorphic nature of the germinal PTCH1 mutation in this family. Furthermore, all BCCs had a similar tumour mutational burden compared to BCCs of unrelated NBCCS patients while harbouring a higher number of damaging PTCH1 mutations., Conclusions: Our data suggest that a sequence of three genetic hits leads to the late development of BCCs in two brothers with NBCCS: a hypomorphic germline mutation, followed by somatic LOH and additional mutations that complete PTCH1 inactivation. These genetic events are in line with the late occurrence of the first BCC and with the higher number of damaging PTCH1 mutations compared to usual cases of NBCCS., (© 2020 European Academy of Dermatology and Venereology.)
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- 2021
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30. [Intrahepatic sarcoma of the follicular dendritic cells].
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Fritzsche FR, Bode B, Thies S, Donati OF, Schiesser M, Clavien PA, and Jochum W
- Subjects
- Aged, Biomarkers, Tumor analysis, Biopsy, Needle, Castleman Disease pathology, Dendritic Cells, Follicular pathology, Fatal Outcome, Female, Humans, Liver pathology, Lymph Nodes pathology, Neoplasm Staging, Dendritic Cell Sarcoma, Follicular pathology, Liver Neoplasms pathology
- Abstract
We report an intrahepatic sarcoma of the follicular dendritic cells in a 76-year-old woman with a medical history of a hyaline-vascular type of Castleman's disease. We discuss the clinico-pathological findings, the pathogenesis and the differential diagnosis of this rare tumour entity.
- Published
- 2010
- Full Text
- View/download PDF
31. [Sialolipoma of the parotid gland].
- Author
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Fritzsche FR, Bode PK, Stinn B, Huber GF, and Noske A
- Subjects
- Adult, Diagnosis, Differential, Humans, Lipoma surgery, Magnetic Resonance Imaging, Male, Parotid Gland pathology, Parotid Gland surgery, Parotid Neoplasms surgery, Lipoma diagnosis, Lipoma pathology, Parotid Neoplasms diagnosis, Parotid Neoplasms pathology
- Abstract
Sialolipoma is a relatively new and rare variant of lipoma of the salivary glands characterized by the combination of classical lipoma morphology with non-neoplastic ductulo-acinary salivary tissue components. Including the presented case, 27 sialolipomas, 14 of them localized in the parotid gland, have been published. We describe the clinical, radiological and pathomorphological characteristics of a parotid sialolipoma in a 43-year-old man.
- Published
- 2009
- Full Text
- View/download PDF
32. Co-expression and prognostic value of gross cystic disease fluid protein 15 and mammaglobin in primary breast cancer.
- Author
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Fritzsche FR, Thomas A, Winzer KJ, Beyer B, Dankof A, Bellach J, Dahl E, Dietel M, and Kristiansen G
- Subjects
- Breast Neoplasms mortality, Breast Neoplasms pathology, Carcinoma, Ductal, Breast mortality, Carcinoma, Ductal, Breast pathology, Carcinoma, Lobular mortality, Carcinoma, Lobular pathology, Cell Count, Disease-Free Survival, Female, Humans, Mammaglobin A, Membrane Transport Proteins, Middle Aged, Survival Rate, Biomarkers, Tumor metabolism, Breast Neoplasms metabolism, Carcinoma, Ductal, Breast metabolism, Carcinoma, Lobular metabolism, Carrier Proteins metabolism, Glycoproteins metabolism, Neoplasm Proteins metabolism, Uteroglobin metabolism
- Abstract
Gross cystic disease fluid protein (GCDFP-15) and mammaglobin are both widely used and accepted markers for epithelia of breast origin. We aimed to evaluate their relation of expression on parallel whole tissue sections in primary breast cancer by immunohistochemistry and also to correlate it with clinico-pathological parameters including patient survival. Primary breast carcinomas from 165 patients with a mean clinical follow-up of 73 months were immunostained using commercially available antibodies against GCDFP-15 and mammaglobin. An immunoreactive score (IRS) was calculated based on the cytoplasmic staining intensity and the number of cells stained. Cytoplasmic expression of GCDFP-15 and mammaglobin was observed in 73.3% and 72.1% of invasive breast carcinomas respectively. 91.8% of breast cancer cases expressed at least one of both markers. Both markers strongly correlated with each other and were significantly associated with lower tumour grading. Additionally, GCDFP-15 negativity was significantly associated with shortened disease-free survival times in univariate and multivariate analyses. We demonstrated the strong correlation of GCDFP-15 and mammaglobin with each other and showed that only very few primary breast cancers are completely negative for both markers. The significantly longer disease free survival times for patients with GCDFP-15 positive tumours clearly warrants further study.
- Published
- 2007
- Full Text
- View/download PDF
33. Expression of AGR2 in non small cell lung cancer.
- Author
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Fritzsche FR, Dahl E, Dankof A, Burkhardt M, Pahl S, Petersen I, Dietel M, and Kristiansen G
- Subjects
- Adenocarcinoma mortality, Adenocarcinoma pathology, Adult, Aged, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Female, Follow-Up Studies, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lung Neoplasms mortality, Lung Neoplasms pathology, Male, Middle Aged, Mucoproteins, Neoplasm Invasiveness, Neoplasm Staging, Oncogene Proteins, Prognosis, Proportional Hazards Models, Time Factors, Tissue Array Analysis, Adenocarcinoma chemistry, Carcinoma, Non-Small-Cell Lung chemistry, Carcinoma, Squamous Cell chemistry, Lung Neoplasms chemistry, Proteins analysis
- Abstract
We aimed to evaluate immunohistochemically the expression of the human Anterior Gradient-2 (AGR2), a gene which has recently been proposed as an oncogene for lung carcinoma development, in non small cell lung cancer and to correlate the findings to clinico-pathological data including patient survival. 95 cases of NSCLC were immunostained using a polyclonal AGR2 antibody and statistical analyses were applied to test for prognostic and diagnostic associations. AGR2 was expressed in 66.3% of cases, preferentially adenocarcinomas. There were no relevant associations with clinico-pathological parameters. A prognostic value of AGR2 could not be demonstrated neither in multivariate nor in univariate analyses. Interestingly, this is the first study to demonstrate AGR2 expression in squamous cell carcinomas. Although a prognostic value of AGR2 seems unlikely further studies are warranted to investigate the biological role of AGR2 in NSCLC and its differential expression according to histology.
- Published
- 2007
- Full Text
- View/download PDF
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