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418 results on '"Fromont, Gaëlle"'

2. PD-L1 expression and its prognostic value in metastatic papillary renal cell carcinoma: Results from a GETUG multicenter retrospective cohort

Author

Naffrichoux, Jérémie, Poupin, Pierre, Pouillot, William, Linassier, Claude, Rioux-Leclercq, Nathalie, De Vries-Brilland, Manon, Mourey, Loïc, Laguerre, Brigitte, Oudard, Stéphane, Gross-Goupil, Marine, Mousset, Coralie, Gravis, Gwenaelle, Rolland, Frédéric, Moise, Laura, Emambux, Sheik, Vassal, Cécile, Zanetta, Sylvie, Penel, Nicolas, Albiges, Laurence, Fromont, Gaëlle, and Cancel, Mathilde

Published
2024
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4. Endogenous ether lipids differentially promote tumor aggressiveness by regulating the SK3 channel

Author

Papin, Marion, Fontaine, Delphine, Goupille, Caroline, Figiel, Sandy, Domingo, Isabelle, Pinault, Michelle, Guimaraes, Cyrille, Guyon, Nina, Cartron, Pierre François, Emond, Patrick, Lefevre, Antoine, Gueguinou, Maxime, Crottès, David, Jaffrès, Paul-Alain, Ouldamer, Lobna, Maheo, Karine, Fromont, Gaëlle, Potier-Cartereau, Marie, Bougnoux, Philippe, Chantôme, Aurélie, and Vandier, Christophe

Published
2024
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5. Expanding inclusion criteria for active surveillance in intermediate-risk prostate cancer: a machine learning approach

Author

Baboudjian, Michael, Breda, Alberto, Roumeguère, Thierry, Uleri, Alessandro, Roche, Jean-Baptiste, Touzani, Alae, Lacetera, Vito, Beauval, Jean-Baptiste, Diamand, Romain, Simone, Guiseppe, Windisch, Olivier, Benamran, Daniel, Fourcade, Alexandre, Fiard, Gaelle, Durand-Labrunie, Camille, Roumiguié, Mathieu, Sanguedolce, Francesco, Oderda, Marco, Barret, Eric, Fromont, Gaëlle, Dariane, Charles, Charvet, Anne-Laure, Gondran-Tellier, Bastien, Bastide, Cyrille, Lechevallier, Eric, Palou, Joan, Ruffion, Alain, Van Der Bergh, Roderick C. N., Peltier, Alexandre, and Ploussard, Guillaume

Published
2023
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8. Heterogeneity of contemporary grade group 4 prostate cancer in radical prostatectomy specimens

Author

Martini, Alberto, Touzani, Alae, Beauval, Jean-Baptiste, Ruffion, Alain, Olivier, Jonathan, Gasmi, Anis, Dariane, Charles, Thoulouzan, Matthieu, Barret, Eric, Brureau, Laurent, Créhange, Gilles, Fiard, Gaëlle, Gauthé, Mathieu, Renard-Penna, Raphaële, Roubaud, Guilhem, Sargos, Paul, Roumiguié, Mathieu, Timsit, Marc-Olivier, Mathieu, Romain, Villers, Arnauld, Rouprêt, Morgan, Fromont, Gaëlle, and Ploussard, Guillaume

Published
2022
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9. Grade group 1 prostate cancer on biopsy: are we still missing aggressive disease in the era of image-directed therapy?

Author

Baboudjian, Michael, Roumiguié, Mathieu, Peltier, Alexandre, Oderda, Marco, Barret, Eric, Fromont, Gaëlle, Dariane, Charles, Fiard, Gaelle, Charvet, Anne-Laure, Gondran-Tellier, Bastien, Durand-Labrunie, Camille, Campello, Pierre Vincent, Roumeguère, Thierry, Diamand, Romain, Diana, Pietro, Touzani, Alae, Beauval, Jean-Baptiste, Daniel, Laurent, Rouprêt, Morgan, Ruffion, Alain, and Ploussard, Guillaume

Published
2022
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10. Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research

Author

Potier-Cartereau, Marie, Raoul, William, Weber, Gunther, Mahéo, Karine, Rapetti-Mauss, Raphael, Gueguinou, Maxime, Buscaglia, Paul, Goupille, Caroline, Le Goux, Nelig, Abdoul-Azize, Souleymane, Lecomte, Thierry, Fromont, Gaëlle, Chantome, Aurélie, Mignen, Olivier, Soriani, Olivier, Vandier, Christophe, Pedersen, Stine Helene Falsig, Editor-in-Chief, Barber, Diane L., Series Editor, Cordat, Emmanuelle, Series Editor, Kajimura, Mayumi, Series Editor, Leipziger, Jens G., Series Editor, O'Donnell, Martha E., Series Editor, Pardo, Luis A., Series Editor, Schmitt, Nicole, Series Editor, and Stock, Christian, Series Editor

Published
2022
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11. Persistent organochlorine pesticides in periprostatic adipose tissue from men with prostate cancer: Ethno-geographic variations, association with disease aggressiveness

Author

Antignac, Jean-Philippe, Figiel, Sandy, Pinault, Michèle, Blanchet, Pascal, Bruyère, Franck, Mathieu, Romain, Lebdai, Souhil, Fournier, Georges, Rigaud, Jerome, Mahéo, Karine, Marchand, Philippe, Guiffard, Ingrid, Bichon, Emmanuelle, le Bizec, Bruno, Multigner, Luc, and Fromont, Gaëlle

Published
2023
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12. Investigation of the RB1-SOX2 axis constitutes a tool for viral status determination and diagnosis in Merkel cell carcinoma

Author

Thanguturi, Soumanth, Tallet, Anne, Miquelestorena-Standley, Elodie, Coco, Catherine, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Blom, Astrid, Saiag, Philippe, Beneton, Nathalie, Bens, Guido, Zaragoza, Julia, Nardin, Charlee, Aubin, François, Dinulescu, Monica, Machet, Marie-Christine, Houben, Roland, Schrama, David, Collin, Christine, Fromont, Gaëlle, Jullie, Marie-Laure, Macagno, Nicolas, Gaboriaud, Pauline, Berthon, Patricia, Touzé, Antoine, Guyétant, Serge, Samimi, Mahtab, and Kervarrec, Thibault

Published
2022
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15. Annual nationwide analysis of costs and post-operative outcomes after radical prostatectomy according to the surgical approach (open, laparoscopic, and robotic)

Author

Ploussard, Guillaume, Grabia, Annabelle, Barret, Eric, Beauval, Jean-Baptiste, Brureau, Laurent, Créhange, Gilles, Dariane, Charles, Fiard, Gaëlle, Fromont, Gaëlle, Gauthé, Mathieu, Mathieu, Romain, Renard-Penna, Raphaële, Roubaud, Guilhem, Ruffion, Alain, Sargos, Paul, Rouprêt, Morgan, and Lequeu, Charles-Edouard

Published
2022
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16. Understanding natural isotopic variations in cultured cancer cells.

Author

Mantha, Olivier L., Mahé, Marie, Mahéo, Karine, Fromont, Gaëlle, Guéguinou, Maxime, Tea, Illa, Hankard, Régis, and De Luca, Arnaud

Subjects
CELL culture, NITROGEN isotopes, MODULATION (Music theory), CELL lines, CANCER cells
Abstract

Rationale: Natural variations in the abundance of the stable isotopes of nitrogen (δ15N) and carbon (δ13C) offer valuable insights into metabolic fluxes. In the wake of strong interest in cancer metabolism, recent research has revealed δ15N and δ13C variations in cancerous compared to non‐cancerous tissues and cell lines. However, our understanding of natural isotopic variations in cultured mammalian cells, particularly in relation to metabolism, remains limited. This study aims to start addressing this gap using metabolic modulations in cells cultured under controlled conditions. Methods: Prostate cancer cells (PC3) were cultured in different conditions and their δ15N and δ13C were measured using isotope ratio mass spectrometry. Isotopic variations during successive cell culture passages were assessed and two widely used cell culture media (RPMI and DMEM) were compared. Metabolism was modulated through glutamine deprivation and hypoxia. Results: Successive cell culture passages generally resulted in reproducible δ15N and δ13C values. The impact of culture medium composition on δ15N and δ13C of the cells highlights the importance of maintaining a consistent medium composition across conditions whenever possible. Glutamine deprivation and hypoxia induced a lower δ13C in bulk cell samples, with only the former affecting δ15N. Gaps between theory and experiments were bridged and the lessons learned throughout the process are provided. Conclusions: Exposing cultured cancer cells to hypoxia allowed us to further investigate the relation between metabolic modulations and natural isotopic variations, while mitigating the confounding impact of changing culture medium composition. This study highlights the potential of natural δ13C variations for studying substrate fluxes and nutrient allocation in reproducible culture conditions. Considering cell yield and culture medium composition is pivotal to the success of this approach. [ABSTRACT FROM AUTHOR]

Published
2024
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17. PARP inhibitors in prostate cancers, is it time for combinations?

Author

Teyssonneau, Diego, Dariane, Charles, Barret, Eric, Beauval, Jean-Baptiste, Brureau, Laurent, Fiard, Gaëlle, Fromont, Gaëlle, Créhange, Gilles, Gauthé, Mathieu, Ruffion, Alain, Renard-Penna, Raphaële, Mathieu, Romain, Sargos, Paul, Rouprêt, Morgan, Ploussard, Guillaume, and Roubaud, Guilhem

Abstract

Despite several improvements in outcomes, metastatic prostate cancer remains deadly. Alterations in the homologous recombination repair (HRR) pathway are associated with more aggressive disease. Olaparib and rucaparib, two poly-ADP-ribose polymerase (PARP) inhibitors, have received approval from the authorities of several countries for their anti-tumoral effects in patients with metastatic castration-resistant prostate cancers harboring HRR gene alterations, in particular BRCA2. More recently, it has been hypothesized that new hormonal therapies (NHTs) and PARP inhibitors (PARPi) could have synergistic actions and act independently of HRR deficiency. This review proposes to discuss the advantages and disadvantages of PARPi used as monotherapy or in combination with NHTs and whether there is a need for molecular selection. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Comprehensive analyses of immune tumor microenvironment in papillary renal cell carcinoma

Author

de Vries-Brilland, Manon, primary, Rioux-Leclercq, Nathalie, additional, Meylan, Maxime, additional, Dauvé, Jonathan, additional, Passot, Christophe, additional, Spirina-Menand, Elena, additional, Flippot, Ronan, additional, Fromont, Gaëlle, additional, Gravis, Gwenaelle, additional, Geoffrois, Lionnel, additional, Chevreau, Christine, additional, Rolland, Fréderic, additional, Blanc, Ellen, additional, Lefort, Félix, additional, Ravaud, Alain, additional, Gross-Goupil, Marine, additional, Escudier, Bernard, additional, Negrier, Sylvie, additional, and Albiges, Laurence, additional

Published
2023
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19. Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma

Author

Kervarrec, Thibault, Tallet, Anne, Miquelestorena-Standley, Elodie, Houben, Roland, Schrama, David, Gambichler, Thilo, Berthon, Patricia, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Aubin, Francois, Bens, Guido, Tabareau-Delalande, Flore, Beneton, Nathalie, Fromont, Gaëlle, Arbion, Flavie, Leteurtre, Emmanuelle, Herfs, Michael, Touzé, Antoine, Samimi, Mahtab, and Guyétant, Serge

Published
2019
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22. Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomas

Author

Kervarrec, Thibault, Tallet, Anne, Miquelestorena-Standley, Elodie, Houben, Roland, Schrama, David, Gambichler, Thilo, Berthon, Patricia, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Aubin, Francois, Bens, Guido, Tabareau-Delalande, Flore, Beneton, Nathalie, Fromont, Gaëlle, Arbion, Flavie, Leteurtre, Emmanuelle, Touzé, Antoine, Samimi, Mahtab, and Guyétant, Serge

Published
2019
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25. Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research

Author

Potier-Cartereau, Marie, primary, Raoul, William, additional, Weber, Gunther, additional, Mahéo, Karine, additional, Rapetti-Mauss, Raphael, additional, Gueguinou, Maxime, additional, Buscaglia, Paul, additional, Goupille, Caroline, additional, Le Goux, Nelig, additional, Abdoul-Azize, Souleymane, additional, Lecomte, Thierry, additional, Fromont, Gaëlle, additional, Chantome, Aurélie, additional, Mignen, Olivier, additional, Soriani, Olivier, additional, and Vandier, Christophe, additional

Published
2020
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27. Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in African–Caribbean and Caucasian patients

Author

Figiel, Sandy, Pinault, Michelle, Domingo, Isabelle, Guimaraes, Cyrille, Guibon, Roseline, Besson, Pierre, Tavernier, Elsa, Blanchet, Pascal, Multigner, Luc, Bruyère, Franck, Haillot, Olivier, Mathieu, Romain, Vincendeau, Sebastien, Rioux-Leclercq, Nathalie, Lebdai, Souhil, Azzouzi, Abdel-Rahmene, Perrouin-Verbe, Marie-Aimee, Fournier, Georges, Doucet, Laurent, Rigaud, Jerome, Renaudin, Karine, Mahéo, Karine, and Fromont, Gaëlle

Published
2018
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30. Padeliporfin vascular-targeted photodynamic therapy versus active surveillance in men with low-risk prostate cancer (CLIN1001 PCM301): an open-label, phase 3, randomised controlled trial

Author

Azzouzi, Abdel-Rahmène, Vincendeau, Sébastien, Barret, Eric, Cicco, Antony, Kleinclauss, François, van der Poel, Henk G, Stief, Christian G, Rassweiler, Jens, Salomon, Georg, Solsona, Eduardo, Alcaraz, Antonio, Tammela, Teuvo T, Rosario, Derek J, Gomez-Veiga, Francisco, Ahlgren, Göran, Benzaghou, Fawzi, Gaillac, Bertrand, Amzal, Billy, Debruyne, Frans M J, Fromont, Gaëlle, Gratzke, Christian, and Emberton, Mark

Published
2017
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33. Data from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases

Author

Chantôme, Aurélie, primary, Potier-Cartereau, Marie, primary, Clarysse, Lucie, primary, Fromont, Gaëlle, primary, Marionneau-Lambot, Séverine, primary, Guéguinou, Maxime, primary, Pagès, Jean-Christophe, primary, Collin, Christine, primary, Oullier, Thibauld, primary, Girault, Alban, primary, Arbion, Flavie, primary, Haelters, Jean-Pierre, primary, Jaffrès, Paul-Alain, primary, Pinault, Michelle, primary, Besson, Pierre, primary, Joulin, Virginie, primary, Bougnoux, Philippe, primary, and Vandier, Christophe, primary

Published
2023
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34. Supplementary Methods from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases

Author

Chantôme, Aurélie, primary, Potier-Cartereau, Marie, primary, Clarysse, Lucie, primary, Fromont, Gaëlle, primary, Marionneau-Lambot, Séverine, primary, Guéguinou, Maxime, primary, Pagès, Jean-Christophe, primary, Collin, Christine, primary, Oullier, Thibauld, primary, Girault, Alban, primary, Arbion, Flavie, primary, Haelters, Jean-Pierre, primary, Jaffrès, Paul-Alain, primary, Pinault, Michelle, primary, Besson, Pierre, primary, Joulin, Virginie, primary, Bougnoux, Philippe, primary, and Vandier, Christophe, primary

Published
2023
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35. Supplementary Figures 1 - 5 from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases

Author

Chantôme, Aurélie, primary, Potier-Cartereau, Marie, primary, Clarysse, Lucie, primary, Fromont, Gaëlle, primary, Marionneau-Lambot, Séverine, primary, Guéguinou, Maxime, primary, Pagès, Jean-Christophe, primary, Collin, Christine, primary, Oullier, Thibauld, primary, Girault, Alban, primary, Arbion, Flavie, primary, Haelters, Jean-Pierre, primary, Jaffrès, Paul-Alain, primary, Pinault, Michelle, primary, Besson, Pierre, primary, Joulin, Virginie, primary, Bougnoux, Philippe, primary, and Vandier, Christophe, primary

Published
2023
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42. Perioperative outcomes after radical prostatectomy: does the surgical approach change the impact of hospital volume? A nationwide analysis

Author

BABOUDJIAN, Michael, primary, GONDRAN-TELLIER, Bastien, additional, GRABIA, Annabelle, additional, BARRET, Eric, additional, BEAUVAL, Jean-Baptiste, additional, BRUREAU, Laurent, additional, CREHANGE, Gilles, additional, DARIANE, Charles, additional, FIARD, Gaëlle, additional, FROMONT, Gaëlle, additional, GAUTHE, Mathieu, additional, MATHIEU, Romain, additional, RENARD-PENNA, Raphaële, additional, ROUBAUD, Guilhem, additional, RUFFION, Alain, additional, SARGOS, Paul, additional, LEQUEU, Charles-Edouard, additional, ROUPRET, Morgan, additional, and PLOUSSARD, Guillaume, additional

Published
2022
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45. Micro-ultrasound-guided biopsies versus systematic biopsies in the detection of prostate cancer: a systematic review and meta-analysis

Author

Dariane, Charles, Ploussard, Guillaume, Barret, Eric, Beauval, Jean-Baptiste, Brureau, Laurent, Créhange, Gilles, Fromont, Gaëlle, Gauthé, Mathieu, Mathieu, Romain, Renard-Penna, Raphaële, Roubaud, Guilhem, Ruffion, Alain, Sargos, Paul, Rouprêt, Morgan, Fiard, Gaëlle, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut Curie [Paris], CHU Pontchaillou [Rennes], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Bergonié [Bordeaux], UNICANCER, Hospices Civils de Lyon (HCL), Centre pour l'innovation en cancérologie de Lyon (CICLY), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Service d'urologie [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Gestes Medico-chirurgicaux Assistés par Ordinateur (TIMC-GMCAO), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), and None

Subjects
meta-analysis, micro-ultrasound, targeted biopsies, systematic biopsies, prostate cancer, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Purpose: The diagnosis of prostate cancer (PCa) still relies on the performance of both targeted (TB) and systematic biopsies (SB). Micro-ultrasound (mUS)-guided biopsies demonstrated a high sensitivity in detecting clinically significant prostate cancer (csPCa), which could be comparable to that of magnetic resonance imaging (MRI)-TB, but their added value has not been compared to SB yet.Methods: We conducted a systematic review and meta-analysis, based on Medline, EMBASE, Scopus, and Web of Science, in accordance with PRISMA guidelines, to compare mUS-guided biopsies to SB.Results: Based on the literature search of 2957 articles, 15 met the inclusion criteria (2967 patients). Most patients underwent mUS-guided biopsies, followed by MRI-TB and SB. Respectively 5 (n = 670) and 4 (n = 467) studies, providing raw data on SB, were included in a random-effect meta-analysis of the detection rate of csPCa, i.e. Gleason Grade Group (GGG) ≥ 2 or non-csPCa (GGG = 1). Overall, PCa was detected in 56-71% of men, with 31.3-49% having csPCa and 17-25.4% having non-csPCa. Regarding csPCa, mUS-guided biopsies identified 196 and SB 169 cases (Detection Ratio (DR): 1.18, 95% CI 0.83-1.68, I2 = 69%), favoring mUS-guided biopsies; regarding non-csPCa, mUS-guided biopsies identified 62 and SB 115 cases (DR: 0.55, 95% CI 0.41-0.73, I2 = 0%), also favoring mUS-guided biopsies by decreasing unnecessary diagnosis.Conclusion: Micro-ultrasound-guided biopsies compared favorably with SB for the detection of csPCa and detected fewer non-csPCa than SB. Prospective trials are awaited to confirm the interest of adding mUS-guided biopsies to MRI-TB to optimize csPCa detection without increasing overdiagnosis of non-csPCa.

Published
2022

47. Restaging of Patients with Persistently Elevated Prostate-specific Antigen After Radical Prostatectomy Using [68Ga]-PSMA-11 Positron Emission Tomography/Computed Tomography: Impact on Disease Management

Author

Gauthé, Mathieu, Sargos, Paul, Benziane Ouaritini, Nicolas, Barret, Eric, Beauval, Jean-Baptiste, Brureau, Laurent, Créhange, Gilles, Dariane, Charles, Fiard, Gaëlle, Fromont, Gaëlle, Mathieu, Romain, Renard-Penna, Raphaële, Roubaud, Guilhem, Ruffion, Alain, Rouprêt, Morgan, and Ploussard, Guillaume

Published
2022
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49. Development of a High-Performance Thin-Layer Chromatography Method for the Quantification of Alkyl Glycerolipids and Alkenyl Glycerolipids from Shark and Chimera Oils and Tissues

Author

Papin, Marion, primary, Guimaraes, Cyrille, additional, Pierre-Aue, Benoit, additional, Fontaine, Delphine, additional, Pardessus, Jeoffrey, additional, Couthon, Hélène, additional, Fromont, Gaëlle, additional, Mahéo, Karine, additional, Chantôme, Aurélie, additional, Vandier, Christophe, additional, and Pinault, Michelle, additional

Published
2022
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