37 results on '"Frutos, Rogelio P."'
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2. Stable isotope synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites
3. Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 2: Asymmetric Synthesis via Shi Epoxidation.
4. Carbon 14 and stable isotope synthesis of two potent and selective phosphodiesterase type 4 inhibitors.
5. Carbon 14 synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites.
6. Development of a Scalable Asymmetric Process for the Synthesis of GLYT1 Inhibitor BI 425809 (Iclepertin).
7. Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling.
8. Stereoselective synthesis of 1-aryl-4a-methyloctahydrophenanthrenes via cyclization reactions initiated by benzylic cations
9. Intramolecular formal /3 + 2~ cycloaddition of alkenes and benzylic cations: stereoselective synthesis of 1,2,3,4,4a,9a-hexahydrofluorenes
10. Practical synthesis of a cell adhesion inhibitor by self-regeneration of stereocenters
11. An improved synthesis of N-aryl-hydantoin LFA-1 antagonists via the enantiospecific alkylation of an isobutyraldehyde-derived imidazolidinone template
12. Asymmetric Oxidation of a Dihydrothienopyrimidine
13. Development of a Practical Process for the Synthesis of PDE4 Inhibitors
14. A new and practical boronic acid catalyzed intramolecular cyclodehydration of ureas for the synthesis of LFA-1 antagonists
15. Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation.
16. A General and Practical Synthesis ofN-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors
17. ChemInform Abstract: One‐Pot Synthesis of 2,5‐Disubstituted Pyrimidines from Nitriles.
18. One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles
19. Development of a Safe and Economical Synthesis of Methyl 6-Chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylation on Kilogram Scale
20. Asymmetric Synthesis of LFA-1 Inhibitor BIRT2584 on Metric Ton Scale
21. Efficient Multikilogram Synthesis of 5-Bromo-2-cyclopropyl-1-methyl-1H-imidazole
22. Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis
23. Expedient Synthesis of Substituted Imidazoles from Nitriles.
24. Expedient synthesis of substituted imidazoles from nitriles
25. Development of a Scalable Process for 1-(3,5-Dichlorophenyl)-5-iodo-3-methyl- (4-methylbenzyl)-1H-imidazo[1,2-a]imidazol-2-one: A Key Intermediate for the Synthesis of LFA-1 Inhibitors
26. A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins
27. Regiocontrolled synthesis of highly-functionalized fused imidazoles: a novel synthesis of second generation LFA-1 inhibitors
28. A General and Practical Synthesis of N-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors.
29. Synthesis of protected, chiral α,α-disubstituted α-amino acids via a Beckmann rearrangement
30. Synthesis and characterization of a novel ranitidine dimer
31. Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions
32. Development of a Safe and Economical Synthesis ofMethyl 6-Chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylationon Kilogram Scale.
33. Cyclization reactions terminated by enamides and enecarbamates
34. Intramolecular formal[3+2] cycloaddition of alkenes and benzylic cations. Stereoselective...
35. Synthesis of protected, chiral α,α-disubstituted α-amino acids viaa Beckmann rearrangement
36. Asymmetric Tandem Additions to Chiral 2,3‐Dihydronaphthyloxazolines: Synthesis of the Triptoquinone/Triptinin A Ring System.
37. Asymmetric Tandem Additions to Chiral 2,3-Dihydronaphthyloxazolines: Synthesis of the Triptoquinone/Triptinin A Ring System
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