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21 results on '"Fu, Jin-Jin"'

16. Long non‐coding RNA ELFN1‐AS1‐mediated ZBTB16inhibition augments the progression of gastric cancer by activating the PI3K/AKTaxis

Author

Zhuang, Shao‐Hua, Meng, Chu‐Chen, Fu, Jin‐Jin, and Huang, Jian

Abstract

Long non‐coding RNA ELFN1 antisense RNA 1 (ELFN1‐AS1) has been reported as a cancer driver in many human malignancies. This study was conducted to investigate the function of ELFN1‐AS1 in gastric cancer (GC) and its mechanism of action. Bioinformatics analysis revealed increased expression of ELFN1‐AS1 in GC, and abundant expression of ELFN1‐AS1 was observed in the acquired GC cell lines. Knockdown of ELFN1‐AS1 in GC cells weakened cell proliferation, invasion, migration, and resistance to apoptosis. ELFN1‐AS1 was mainly localized in the nuclei of GC cells. ELFN1‐AS1 recruited DNA methyltransferases to the promoter region of ZBTB16 and induced transcriptional repression of ZBTB16 through methylation modification. Furthermore, downregulation of ZBTB16 activated the phosphatidylinositol 3‐kinase/protein kinase B (PI3K/AKT) signaling pathway and restored the proliferation and invasiveness of GC cells. In vivo, downregulation of ELFN1‐AS1 reduced the growth rate of xenograft tumors in mice. In summary, this study demonstrates that ELFN1‐AS1 recruits DNA methyltransferases to the promoter region of ZBTB16 to induce its transcriptional repression, which further augments the development of GC by activating the PI3K/AKT signaling pathway.

Published
2022
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19. Role and application of quorum sensing in anaerobic ammonium oxidation (anammox) process: A review.

Author

Zhang, Quan, Fan, Nian-Si, Fu, Jin-Jin, Huang, Bao-Cheng, and Jin, Ren-Cun

Subjects
QUORUM sensing, MICROBIAL aggregation, AMMONIUM, OXIDATION, NITROGEN removal (Water purification)
Abstract

Anaerobic ammonium oxidation (anammox) is a promising biological nitrogen removal process, due to its advantages of high efficiency and low cost. However, problems remain in the application, such as long startup period and susceptibility to environmental variations. Quorum sensing (QS), as a means of bacterial communication, attracts more attentions in regulating aggregation behavior and microbial density. Many physiological characteristics of anammox bacteria have been confirmed to be associated with QS, including specific anammox activity, growth rate and the production of extracellular polymeric substances (EPS), which directly affect the performance of anammox process. Therefore, a comprehensive understanding of the QS in anammox process is prerequisite. This work systematically reviewed the role and application of QS in the anammox process with the focus on mechanism. Additionally, current challenges and research needs were proposed. [ABSTRACT FROM AUTHOR]

Published
2021
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