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1. Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Author

Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., de Queiroz, J.P., Coutts, Shelagh B, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, and Hill, Michael D

Published
2024
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2. The Hippo pathway mediates Semaphorin signaling

Author

Meng, Zhipeng, Li, Fu-Long, Fang, Cao, Yeoman, Benjamin, Qiu, Yunjiang, Wang, Ying, Cai, Xiaomin, Lin, Kimberly C, Yang, Di, Luo, Min, Fu, Vivian, Ma, Xiaoxiao, Diao, Yarui, Giancotti, Filippo G, Ren, Bing, Engler, Adam J, and Guan, Kun-Liang

Subjects
Cancer, Genetics, Underpinning research, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Aetiology
Abstract

Semaphorins were originally identified as axonal guidance molecules, but they also control processes such as vascular development and tumorigenesis. The downstream signaling cascades of Semaphorins in these biological processes remain unclear. Here, we show that the class 3 Semaphorins (SEMA3s) activate the Hippo pathway to attenuate tissue growth, angiogenesis, and tumorigenesis. SEMA3B restoration in lung cancer cells with SEMA3B loss of heterozygosity suppresses cancer cell growth via activating the core Hippo kinases LATS1/2 (large tumor suppressor kinase 1/2). Furthermore, SEMA3 also acts through LATS1/2 to inhibit angiogenesis. We identified p190RhoGAPs as essential partners of the SEMA3A receptor PlexinA in Hippo regulation. Upon SEMA3 treatment, PlexinA interacts with the pseudo-guanosine triphosphatase (GTPase) domain of p190RhoGAP and simultaneously recruits RND GTPases to activate p190RhoGAP, which then stimulates LATS1/2. Disease-associated etiological factors, such as genetic lesions and oscillatory shear, diminish Hippo pathway regulation by SEMA3. Our study thus discovers a critical role of Hippo signaling in mediating SEMA3 physiological function.

Published
2022

5. YAP and TAZ regulate cell volume

Author

Perez-Gonzalez, Nicolas A, Rochman, Nash D, Yao, Kai, Tao, Jiaxiang, Le, Minh-Tam Tran, Flanary, Shannon, Sablich, Lucia, Toler, Ben, Crentsil, Eliana, Takaesu, Felipe, Lambrus, Bram, Huang, Jessie, Fu, Vivian, Chengappa, Pragati, Jones, Tia M, Holland, Andrew J, An, Steven, Wirtz, Denis, Petrie, Ryan J, Guan, Kun-Liang, and Sun, Sean X

Subjects
Biochemistry and Cell Biology, Biological Sciences, Aetiology, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Underpinning research, Cell Cycle, Cell Cycle Proteins, Cell Size, Cells, Cultured, Cytoskeleton, HEK293 Cells, Humans, Trans-Activators, Transcription Factors, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

How mammalian cells regulate their physical size is currently poorly understood, in part due to the difficulty in accurately quantifying cell volume in a high-throughput manner. Here, using the fluorescence exclusion method, we demonstrate that the mechanosensitive transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are regulators of single-cell volume. The role of YAP/TAZ in volume regulation must go beyond its influence on total cell cycle duration or cell shape to explain the observed changes in volume. Moreover, for our experimental conditions, volume regulation by YAP/TAZ is independent of mTOR. Instead, we find that YAP/TAZ directly impacts the cell division volume, and YAP is involved in regulating intracellular cytoplasmic pressure. Based on the idea that YAP/TAZ is a mechanosensor, we find that inhibiting myosin assembly and cell tension slows cell cycle progression from G1 to S. These results suggest that YAP/TAZ may be modulating cell volume in combination with cytoskeletal tension during cell cycle progression.

Published
2019

6. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

Author

Jewell, Jenna L, Fu, Vivian, Hong, Audrey W, Yu, Fa-Xing, Meng, Delong, Melick, Chase H, Wang, Huanyu, Lam, Wai-Ling Macrina, Yuan, Hai-Xin, Taylor, Susan S, and Guan, Kun-Liang

Subjects
Cell Line, Animals, Humans, Cyclic AMP-Dependent Protein Kinases, Receptors, G-Protein-Coupled, Signal Transduction, Protein Processing, Post-Translational, Phosphorylation, Mechanistic Target of Rapamycin Complex 1, Regulatory-Associated Protein of mTOR, cancer biology, cancer cells, cell biology, cells, human, mouse, Protein Processing, Post-Translational, Receptors, G-Protein-Coupled, Biochemistry and Cell Biology
Abstract

The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth, metabolism, and autophagy. Extensive research has focused on pathways that activate mTORC1 like growth factors and amino acids; however, much less is known about signaling cues that directly inhibit mTORC1 activity. Here, we report that G-protein coupled receptors (GPCRs) paired to Gαs proteins increase cyclic adenosine 3'5' monophosphate (cAMP) to activate protein kinase A (PKA) and inhibit mTORC1. Mechanistically, PKA phosphorylates the mTORC1 component Raptor on Ser 791, leading to decreased mTORC1 activity. Consistently, in cells where Raptor Ser 791 is mutated to Ala, mTORC1 activity is partially rescued even after PKA activation. Gαs-coupled GPCRs stimulation leads to inhibition of mTORC1 in multiple cell lines and mouse tissues. Our results uncover a signaling pathway that directly inhibits mTORC1, and suggest that GPCRs paired to Gαs proteins may be potential therapeutic targets for human diseases with hyperactivated mTORC1.

Published
2019

9. Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Author

Hankey, Graeme J., Hackett, Maree L., Almeida, Osvaldo P., Flicker, Leon, Mead, Gillian E., Dennis, Martin S., Etherton-Beer, Christopher, Ford, Andrew H., Billot, Laurent, Jan, Stephen, Lung, Thomas, Murray, Veronica, Lundström, Erik, Anderson, Craig S., Herbert, Robert, Carter, Gregory, Donnan, Geoffrey A., Nguyen, Huy-Thang, Gommans, John, Yi, Qilong, Li, Qiang, Bompoint, Severine, Barrett, Sarah, Claxton, Anne, O'Dea, Julia, Tang, Michelle, Williams, Clare, Peterson, Shenae, Drummond, Christie, Hong, Uyen-Ha, Le, Linh-Thi My, Ngo, Tram-Thi Bich, Mai, Yen-Bao, Han, Huyen-Thanh, Truong, Nhu-Quynh, Nguyen, Huong-Thi, Ngo, Hai-Thanh, Nguyen, -Thi Binh, Ha, Oanh-Thi Kieu, Nguyen, Trang-Le Huyen, Lindley, Richard I., New, Peter, Lee, Andrew, Tran, Thanh-Trung, Le, Loan-Tran Truc Mai, Kieu, Thuy-Le Vu, Nguyen, Sang-Van, Nguyen, Thuy-Anh Diem, Dang, Tam-Nhat, Phan, Hanh-Thi Truc, Vo, Loan-Thi Ngoc, Nguyen, Mai-Hue, Dang, Hanh-Cao, Tran, Hong-Thi, Dam, Linh-Thi Cam, Ngo, Trinh-Thi Kim, Pham, Thai-Nguyen Thanh, Pham, Binh-Nguyen, Dao, Nha-Thi Thanh, Nguyen, Huong-Thi Bich, Le, Linh-Thi Cam, Do, Chi-Minh, Huynh, Huy-Quoc, Tran, Giau-Thi Kim, Le, Oanh-Thi, Tran, Ly-Thi Khanh, Duong, Chinh-Dinh, Kieu, Duong-Van, Le, Na, Nguyen, Hoa-Ngoc, Le, Binh-Van, Nguyen, Long-Thanh, Nguyen, Long-Van, Dinh, Tuan-Quoc, Vo, Tan-Van, Bui, Tram-Ngoc, Hoang, Uyen-Thi To, Nguyen, Hien-Thi Bich, Nguyen, Ha-Thi Thu, Lam, Nga-Thuy, Le, Khanh-Kim, Trinh, Phuong-Thanh, Huynh, Hop-Quang, Nguyen, Thao-Thi Thu, Lu, Huyen-Ngoc, Pham, Tham-Hong, Nguyen, Sam-Hoanh, Le, Ninh-Hong, Nguyen, Giang-Truong, Doan, Bich-Thi, Pham, Sung-Phuoc, Luong, Duong-Huu, Mai, Ha-Van, Tran, Thuc-Van, Do, Phuong-Thi, Le, Hoai-Thi, Nguyen, Chi-Van, Nguyen, Phuong-Doan, Mai, Ton-Duy, Dao, Phuong-Viet, Nguyen, Dung-Tien, Khuong, Dai-Quoc, Vuong, Trung-Xuan, Vu, Lan-Tuong, Ngo, Ngoc-Duc, Dang, Hanh-Hong, Truong, Phuong-Thai, Le, Ngan-Thi, Hoang, Hoa-Van, Do, Chung-Quang, Nguyen, Minh-Thao, Dam, Anh-Hai, Le, Quynh-Nhu, Nguyen, Ngoc-Hoang, Nguyen, Tuyen-Van, Le, Toan-Dinh, Dinh, Ha-Thi Hai, Pham, Cuong-Van, Thach, Khanh-Thi Ngoc, Nguyen, Linh-Hai, Nguyen, Loan-Thi, Le, Vien-Chi, Tran, Phuong-Hong, Nguyen, Tai-Anh, Le, Tuan-Van, Truong, Luyen-Van, Bui, Tue-Chau, Huynh, Ngoc-Xuan, Dinh, Lap-Van, Pham, An-Gia, Le, Trang-Thi Huyen, Nguyen, Vy-Tuong, Nguyen, Yen-Hai, Nguyen, Thang-Ba, Thai, Huy, Pham, Quyen-Thi Ngoc, Dao, Khoa-Duy, Pham, Quoc-Nguyen Bao, Dang, Thuong-Thi Huyen, Dinh, Huong-Huynh To, Tong, Trang-Mai, Vu, Thuy-Thi, Le, Si-Tri, Tran, Tai-Ngoc, Tran, Phuong-Hoai, Dinh, Ngoc-Thuy Nhu, Nguyen, Binh-Thanh, Do, Vinh-Phuong, Nguyen, Anh-Ngoc, Nguyen, Binh-Thi Thanh, Blacker, David, Bunce, Lindsey, Tan, Ai Ling, Ghia, Darshan, Edmonds, Gillian, O'Loughlin, Nicole, Ewing, Megan, Whittaker, Kerri-Ann, Deane, Lorralee, Gawarikar, Yash, Jones, Brett, Lopez, Maria, Nagesh, Koushik, Siracusa, Emma, Davis, Stephen, McDonald, Amy, Tsoleridis, Jess, McCoy, Rachael, Jackson, David, Silver, Gab, Bates, Timothy R., Boudville, Amanda, Southwell, Lynda, Cordato, Dennis, McDougall, Alan J., Cappelen-Smith, Cecilia, Calic, Zeljka, Askar, Shabeel, Cheng, Qi, Kumar, Raymond, Geraghty, Richard, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, McLennan, Cassandra, Sahathevan, Ramesh, Hair, Casey, Levy, Stanley, Macdonald, Beverley, Nham, Benjamin, Rigney, Louise, Nathani, Dev, Gopinath, Sumana, Patel, Vishal, Mamun, Abul, Trewin, Benjamin, Phua, Chun, Choong, Ho, Tarrant, Lauren, Boyle, Kerry, Hewitt, Luisa, Hourn, Monique, Masterson, Amanda, Oakley, Kim, Ruddell, Karen, Sanctuary, Colette, Veitch, Kimberley, Burdusel, Camelia, Lee, Lina, Cheuk, Gary, Christley, Jeremy, Hartwell, Tabitha, Davenport, Craig, Hickey, Kate, Robertson, Rosanna, Carr, Michelle, Akbari, Sam, Coyle, Hannah, O'Neill, Megan, Redpath, Cameron, Roberts, Caroline, Tabesh, Marjan, Withiel, Toni, Abeysuriya, Kapila, Granger, Andrew, Abraham, Angela, Chua, Chermaine, Do Nguyen, Dung, Surendran, Vathani, Daines, Melissa, Shivlal, David, Latif, Mudassar, Mughal, Noreen, Morgan, Patricia, Krause, Martin, Priglinger, Miriam, Shandiz, Ehsan E., Day, Susan, Kho, Lay, Pollack, Michael, Dunne, Judith, Baines, Helen, Rees, Merridie, White, Jenni, Withanage, Aicuratiya, Delcourt, Candice, Carcel, Cheryl, Malavera, Alejandra, Kunchok, Amy, Ray, Elizabeth, Pepper, Elizabeth, Duckett, Emily, Ormond, Sally, Moey, Andrew, Kleinig, Timothy, Maxwell, Vanessa, Baldwin, Chantal, Vallat, Wilson, Field, Deborah, Markus, Romesh, Page, Kirsty, Wheelwright, Danielle, Bolitho, Sam, Faux, Steven, Sangvatanakul, Fix, Brown, Alexis, Walker, Susan, Massey, Jennifer, Hayes, Hillary, Katrak, Pesi, Winker, Annie, Zagami, Alessandro, Bailey, Alanah, Mccormack, Sarah, Murray, Andrew, Rollason, Mark, Taylor, Christopher, O'Rourke, Fintan, Kuang, Ye Min, Burnet, Heike, Liu, Yvonne, Wu, Aileen, Ramirez, Diana, Wijeratne, Tissa, Celestino, Sherisse, Low, Essie, Chen, Cynthia, Bergqvist, Jennifer, Evans, Andrew, Leung, Queenie, Jude, Martin, McQueen, Rachael, Mohr, Katherine, Kernaghan, Latitia, Stockle, Paul, Tan, Boon L., Laubscher, Sara, Schmid, Diana, Spooner, Melissa, Lallu, Bhavesh, Pepperell, Bronwen, Chalissery, John, Mahawish, Karim, DeCaigney, Susan, Broughton, Paula, Knight, Karen, Duque, Veronica, McNaughton, Harry, Lanford, Jeremy, Fu, Vivian, and Wong, Lai-Kin

Published
2020
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10. Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Author

Coutts, Shelagh B, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kenney, Carol, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, Hill, Michael D, Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Chen, S., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Cooley, R., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Irons, R., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Biswas, V., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Kerr, E., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Patel, V., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Aissa, M., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., Ismail, M., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., and de Queiroz, J.P.

Abstract

Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality.

Published
2024
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13. Interrogating Hippo Pathway Regulation Using Novel Chemical Probes

Author

Fu, Vivian

Subjects
Biochemistry
Abstract

We herein describe a PITP/-PI4KIII-MAP4K signaling axis that modulates the Hippo pathway in response to plasma membrane PI4P levels. Our study highlights a novel role for PITP/ in regulating the Hippo kinase cascade through the identification of VT01454, a small-molecule inhibitor and Microcolin B analog that induces YAP phosphorylation. We characterize VT01454 as both a potent and specific YAP inhibitor, use bio-orthogonal methods to identify PITP/ as the unequivocal targets of VT01454, and functionally validate the role of PITP/ in Hippo signaling by genetic deletion in HEK293A cells. Finally, we demonstrate that VT01454 inhibition of PITP/ regulates the Hippo pathway by modulation of a plasma membrane pool of PI4P, and that MAP4K6/7 are potential PI4P-interacting proteins.

Published
2020

17. SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction

Author

Dhillon, Rashpal S., primary, Qin, Yiming (Amy), additional, van Ginkel, Paul R., additional, Fu, Vivian X., additional, Vann, James M., additional, Lawton, Alexis J., additional, Green, Cara L., additional, Manchado‐Gobatto, Fúlvia B., additional, Gobatto, Claudio A., additional, Lamming, Dudley W., additional, Prolla, Tomas A., additional, and Denu, John M., additional

Published
2022
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18. A cohesive, person-centric evidence-based model for successful rehabilitation after stroke and other disabling conditions.

Author

McNaughton, Harry, Gommans, John, McPherson, Kathryn, Harwood, Matire, and Fu, Vivian

Subjects
EVALUATION of medical care, WELL-being, OCCUPATIONAL roles, BIOPSYCHOSOCIAL model, ATTITUDES of medical personnel, MOTIVATION (Psychology), NEUROPLASTICITY, SOCIOECONOMIC factors, STROKE rehabilitation, QUALITY of life, PEOPLE with disabilities
Abstract

The article discusses the evolving understanding of rehabilitation, emphasizing the need for a broader perspective that includes psychology, sociology, and other behavioral sciences. It challenges the biomedical approach and advocates for the biopsychosocial model of wellness. It recommends for a reevaluation of rehabilitation dogma and a shift towards a person-centered approach.

Published
2023
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20. SIRT3 deficiency decreases oxidative-metabolism capacity but increases lifespan under caloric restriction

Author

Dhillon, Rashpal S, primary, Qin, Yiming (Amy), additional, van Ginkel, Paul R, additional, Fu, Vivian X, additional, Vann, James M, additional, Lawton, Alexis J, additional, Green, Cara L, additional, Manchado-Gobatto, Fúlvia B, additional, Gobatto, Claudio A, additional, Lamming, Dudley W, additional, Prolla, Tomas A, additional, and Denu, John M, additional

Published
2022
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22. Conserving migratory waterbirds and the coastal zone: the future of South-east Asia's intertidal wetlands

Author

Yong, Ding Li, primary, Kee, Jing Ying, additional, Aung, Pyae Phyo, additional, Jain, Anuj, additional, Yeap, Chin-Aik, additional, Au, Nyat Jun, additional, Jearwattanakanok, Ayuwat, additional, Lim, Kim Keang, additional, Yu, Yat-Tung, additional, Fu, Vivian W. K., additional, Insua-Cao, Paul, additional, Sawa, Yusuke, additional, Crosby, Mike, additional, Chan, Simba, additional, and Crockford, Nicola J., additional

Published
2021
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24. Economic analysis of the ‘Take Charge’ intervention for people following stroke: Results from a randomised trial

Author

Te Ao, Braden, primary, Harwood, Matire, additional, Fu, Vivian, additional, Weatherall, Mark, additional, McPherson, Kathryn, additional, Taylor, William J, additional, McRae, Anna, additional, Thomson, Tom, additional, Gommans, John, additional, Green, Geoff, additional, Ranta, Annemarei, additional, Hanger, Carl, additional, Riley, Judith, additional, and McNaughton, Harry, additional

Published
2021
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25. Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration

Author

Hankey, Graeme J., primary, Hackett, Maree L., additional, Almeida, Osvaldo P., additional, Flicker, Leon, additional, Mead, Gillian E., additional, Dennis, Martin S., additional, Etherton-Beer, Christopher, additional, Ford, Andrew H., additional, Billot, Laurent, additional, Jan, Stephen, additional, Lung, Thomas, additional, Lundström, Erik, additional, Sunnerhagen, Katharina S., additional, Anderson, Craig S., additional, Thang-Nguyen, Huy, additional, Gommans, John, additional, Yi, Qilong, additional, Murray, Veronica, additional, Herbert, Robert, additional, Carter, Gregory, additional, Donnan, Geoffrey A., additional, Nguyen, Huy-Thang, additional, Li, Qiang, additional, Bompoint, Severine, additional, Barrett, Sarah, additional, Claxton, Anne, additional, O’Dea, Julia, additional, Tang, Michelle, additional, Williams, Clare, additional, Peterson, Shenae, additional, Drummond, Christie, additional, Hong, Uyen-Ha, additional, My Le, Linh-Thi, additional, Bich Ngo, Tram-Thi, additional, Mai, Yen-Bao, additional, Han, Huyen-Thanh, additional, Truong, Nhu-Quynh, additional, Nguyen, Huong-Thi, additional, Ngo, Hai-Thanh, additional, Nguyen, Thi Binh, additional, Kieu Ha, Oanh-Thi, additional, Huyen Nguyen, Trang-Le, additional, Lindley, Richard I., additional, New, Peter, additional, Lee, Andrew, additional, Tran, Thanh-Trung, additional, Truc Mai Le, Loan-Tran, additional, Vu Kieu, Thuy-Le, additional, Nguyen, Sang-Van, additional, Diem Nguyen, Thuy-Anh, additional, Dang, Tam-Nhat, additional, Truc Phan, Hanh-Thi, additional, Ngoc Vo, Loan-Thi, additional, Nguyen, Mai-Hue, additional, Dang, Hanh-Cao, additional, Tran, Hong-Thi, additional, Cam Dam, Linh-Thi, additional, Kim Ngo, Trinh-Thi, additional, Thanh Pham, Thai-Nguyen, additional, Pham, Binh-Nguyen, additional, Thanh Dao, Nha-Thi, additional, Bich Nguyen, Huong-Thi, additional, Cam Le, Linh-Thi, additional, Do, Chi-Minh, additional, Huynh, Huy-Quoc, additional, Tran, Giau-Thi Kim, additional, Le, Oanh-Thi, additional, Khanh Tran, Ly-Thi, additional, Duong, Chinh-Dinh, additional, Kieu, Duong-Van, additional, Le, Na, additional, Nguyen, Hoa-Ngoc, additional, Le, Binh-Van, additional, Nguyen, Long-Thanh, additional, Nguyen, Long-Van, additional, Dinh, Tuan-Quoc, additional, Vo, Tan-Van, additional, Bui, Tram-Ngoc, additional, To Hoang, Uyen-Thi, additional, Bich Nguyen, Hien-Thi, additional, Thu Nguyen, Ha-Thi, additional, Lam, Nga-Thuy, additional, Le, Khanh-Kim, additional, Trinh, Phuong-Thanh, additional, Huynh, Hop-Quang, additional, Thu Nguyen, Thao-Thi, additional, Lu, Huyen-Ngoc, additional, Pham, Tham-Hong, additional, Nguyen, Sam-Hoanh, additional, Le, Ninh-Hong, additional, Nguyen, Giang-Truong, additional, Doan, Bich-Thi, additional, Pham, Sung-Phuoc, additional, Luong, Duong-Huu, additional, Mai, Ha-Van, additional, Tran, Thuc-Van, additional, Do, Phuong-Thi, additional, Le, Hoai-Thi, additional, Nguyen, Chi-Van, additional, Nguyen, Phuong-Doan, additional, Mai, Ton-Duy, additional, Dao, Phuong-Viet, additional, Nguyen, Dung-Tien, additional, Khuong, Dai-Quoc, additional, Vuong, Trung-Xuan, additional, Vu, Lan-Tuong, additional, Ngo, Ngoc-Duc, additional, Dang, Hanh-Hong, additional, Truong, Phuong-Thai, additional, Le, Ngan-Thi, additional, Hoang, Hoa-Van, additional, Do, Chung-Quang, additional, Nguyen, Minh-Thao, additional, Dam, Anh-Hai, additional, Le, Quynh-Nhu, additional, Nguyen, Ngoc-Hoang, additional, Nguyen, Tuyen-Van, additional, Le, Toan-Dinh, additional, Hai Dinh, Ha-Thi, additional, Pham, Cuong–Van, additional, Ngoc Thach, Khanh-Thi, additional, Nguyen, Linh-Hai, additional, Nguyen, Loan-Thi, additional, Le, Vien-Chi, additional, Tran, Phuong-Hong, additional, Nguyen, Tai-Anh, additional, Le, Tuan-Van, additional, Truong, Luyen-Van, additional, Bui, Tue-Chau, additional, Huynh, Ngoc-Xuan, additional, Dinh, Lap-Van, additional, Pham, An-Gia, additional, Huyen Le, Trang-Thi, additional, Nguyen, Vy-Tuong, additional, Nguyen, Yen-Hai, additional, Nguyen, Thang-Ba, additional, Thai, Huy, additional, Ngoc Pham, Quyen-Thi, additional, Dao, Khoa-Duy, additional, Bao Pham, Quoc-Nguyen, additional, Huyen Dang, Thuong-Thi, additional, To Dinh, Huong-Huynh, additional, Tong, Trang-Mai, additional, Vu, Thuy-Thi, additional, Le, Si-Tri, additional, Tran, Tai-Ngoc, additional, Tran, Phuong-Hoai, additional, Nhu Dinh, Ngoc-Thuy, additional, Nguyen, Binh-Thanh, additional, Do, Vinh-Phuong, additional, Nguyen, Anh-Ngoc, additional, Thanh Nguyen, Binh-Thi, additional, Blacker, David, additional, Bunce, Lindsey, additional, Tan, Ai Ling, additional, Ghia, Darshan, additional, Edmonds, Gillian, additional, O’Loughlin, Nicole, additional, Ewing, Megan, additional, Whittaker, Kerri-Ann, additional, Deane, Lorralee, additional, Gawarikar, Yash, additional, Jones, Brett, additional, Lopez, Maria, additional, Nagesh, Koushik, additional, Siracusa, Emma, additional, Davis, Stephen, additional, McDonald, Amy, additional, Tsoleridis, Jess, additional, McCoy, Rachael, additional, Jackson, David, additional, Silver, Gab, additional, Bates, Timothy R., additional, Boudville, Amanda, additional, Southwell, Lynda, additional, Cordato, Dennis, additional, McDougall, Alan J., additional, Cappelen-Smith, Cecilia, additional, Calic, Zeljka, additional, Askar, Shabeel, additional, Cheng, Qi, additional, Kumar, Raymond, additional, Geraghty, Richard, additional, Duroux, Maree, additional, Ratcliffe, Megan, additional, Shone, Samantha, additional, McLennan, Cassandra, additional, Sahathevan, Ramesh, additional, Hair, Casey, additional, Levy, Stanley, additional, Macdonald, Beverley, additional, Nham, Benjamin, additional, Rigney, Louise, additional, Nathani, Dev, additional, Gopinath, Sumana, additional, Patel, Vishal, additional, Mamun, Abul, additional, Trewin, Benjamin, additional, Phua, Chun, additional, Choong, Ho, additional, Tarrant, Lauren, additional, Boyle, Kerry, additional, Hewitt, Luisa, additional, Hourn, Monique, additional, Masterson, Amanda, additional, Oakley, Kim, additional, Ruddell, Karen, additional, Sanctuary, Colette, additional, Veitch, Kimberley, additional, Burdusel, Camelia, additional, Lee, Lina, additional, Cheuk, Gary, additional, Christley, Jeremy, additional, Hartwell, Tabitha, additional, Davenport, Craig, additional, Hickey, Kate, additional, Robertson, Rosanna, additional, Carr, Michelle, additional, Akbari, Sam, additional, Coyle, Hannah, additional, O’Neill, Megan, additional, Redpath, Cameron, additional, Roberts, Caroline, additional, Tabesh, Marjan, additional, Withiel, Toni, additional, Abeysuriya, Kapila, additional, Granger, Andrew, additional, Abraham, Angela, additional, Chua, Chermaine, additional, Nguyen, Dung Do, additional, Surendran, Vathani, additional, Daines, Melissa, additional, Shivlal, David, additional, Latif, Mudassar, additional, Mughal, Noreen, additional, Morgan, Patricia, additional, Krause, Martin, additional, Priglinger, Miriam, additional, Shandiz, Ehsan E., additional, Day, Susan, additional, Kho, Lay, additional, Pollack, Michael, additional, Dunne, Judith, additional, Baines, Helen, additional, Rees, Merridie, additional, White, Jenni, additional, Withanage, Aicuratiya, additional, Delcourt, Candice, additional, Carcel, Cheryl, additional, Malavera, Alejandra, additional, Kunchok, Amy, additional, Ray, Elizabeth, additional, Pepper, Elizabeth, additional, Duckett, Emily, additional, Ormond, Sally, additional, Moey, Andrew, additional, Kleinig, Timothy, additional, Maxwell, Vanessa, additional, Baldwin, Chantal, additional, Vallat, Wilson, additional, Field, Deborah, additional, Markus, Romesh, additional, Page, Kirsty, additional, Wheelwright, Danielle, additional, Bolitho, Sam, additional, Faux, Steven, additional, Sangvatanakul, Fix, additional, Brown, Alexis, additional, Walker, Susan, additional, Massey, Jennifer, additional, Hayes, Hillary, additional, Katrak, Pesi, additional, Winker, Annie, additional, Zagami, Alessandro, additional, Bailey, Alanah, additional, Mccormack, Sarah, additional, Murray, Andrew, additional, Rollason, Mark, additional, Taylor, Christopher, additional, O’Rourke, Fintan, additional, Kuang, Ye Min, additional, Burnet, Heike, additional, Liu, Yvonne, additional, Wu, Aileen, additional, Ramirez, Diana, additional, Wijeratne, Tissa, additional, Celestino, Sherisse, additional, Low, Essie, additional, Chen, Cynthia, additional, Bergqvist, Jennifer, additional, Evans, Andrew, additional, Leung, Queenie, additional, Jude, Martin, additional, McQueen, Rachael, additional, Mohr, Katherine, additional, Kernaghan, Latitia, additional, Stockle, Paul, additional, Tan, Boon L., additional, Laubscher, Sara, additional, Schmid, Diana, additional, Spooner, Melissa, additional, Lallu, Bhavesh, additional, Pepperell, Bronwen, additional, Chalissery, John, additional, Mahawish, Karim, additional, DeCaigney, Susan, additional, Broughton, Paula, additional, Knight, Karen, additional, Duque, Veronica, additional, McNaughton, Harry, additional, Lanford, Jeremy, additional, Fu, Vivian, additional, and Wong, Lai-Kin, additional

Published
2021
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26. sj-pdf-1-cre-10.1177_0269215521993648 – Supplemental material for The effect of the Take Charge intervention on mood, motivation, activation and risk factor management: Analysis of secondary data from the Taking Charge after Stroke (TaCAS) trial

Author

McNaughton, Harry, Weatherall, Mark, McPherson, Kathryn, Fu, Vivian, Taylor, William J, McRae, Anna, Thomson, Tom, Gommans, John, Green, Geoff, Matire Harwood, Annemarei Ranta, Hanger, Carl, and Riley, Judith

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-cre-10.1177_0269215521993648 for The effect of the Take Charge intervention on mood, motivation, activation and risk factor management: Analysis of secondary data from the Taking Charge after Stroke (TaCAS) trial by Harry McNaughton, Mark Weatherall, Kathryn McPherson, Vivian Fu, William J Taylor, Anna McRae, Tom Thomson, John Gommans, Geoff Green, Matire Harwood, Annemarei Ranta, Carl Hanger and Judith Riley in Clinical Rehabilitation

Published
2021
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27. sj-pdf-1-imr-10.1177_03000605211067902 - Supplemental material for Estimating the minimal clinically important difference for the Physical Component Summary of the Short Form 36 for patients with stroke

Author

Fu, Vivian, Weatherall, Mark, and McNaughton, Harry

Subjects
education, 111199 Nutrition and Dietetics not elsewhere classified, Cardiology, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, 110604 Sports Medicine, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 111099 Nursing not elsewhere classified, 111708 Health and Community Services, 160807 Sociological Methodology and Research Methods, 111702 Aged Health Care, 111403 Paediatrics, 110904 Neurology and Neuromuscular Diseases, 110203 Respiratory Diseases, 110315 Otorhinolaryngology, FOS: Clinical medicine, 110319 Psychiatry (incl. Psychotherapy), FOS: Sociology, FOS: Psychology, 110599 Dentistry not elsewhere classified, 110323 Surgery, 110305 Emergency Medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-imr-10.1177_03000605211067902 for Estimating the minimal clinically important difference for the Physical Component Summary of the Short Form 36 for patients with stroke by Vivian Fu, Mark Weatherall and Harry McNaughton in Journal of International Medical Research

Published
2021
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28. sj-pdf-1-cre-10.1177_02692155211040727 – Supplemental material for Economic analysis of the ‘Take Charge’ intervention for people following stroke: Results from a randomised trial

Author

Te Ao, Braden, Harwood, Matire, Fu, Vivian, Weatherall, Mark, McPherson, Kathryn, Taylor, William J, McRae, Anna, Thomson, Tom, Gommans, John, Green, Geoff, Ranta, Annemarei, Hanger, Carl, Riley, Judith, and McNaughton, Harry

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-cre-10.1177_02692155211040727 for Economic analysis of the ‘Take Charge’ intervention for people following stroke: Results from a randomised trial by Braden Te Ao, Matire Harwood, Vivian Fu, Mark Weatherall, Kathryn McPherson, William J Taylor, Anna McRae, Tom Thomson, John Gommans, Geoff Green, Annemarei Ranta, Carl Hanger, Judith Riley and Harry McNaughton in Clinical Rehabilitation

Published
2021
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29. Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration

Author

Hankey, Graeme J., Hackett, Maree, Almeida, Osvaldo P., Flicker, Leon, Mead, Gillian E., Dennis, Martin S., Etherton-Beer, Christopher, Ford, Andrew H., Billot, Laurent, Jan, Stephen, Lung, Thomas, Lundström, Erik, Sunnerhagen, Katharina S., Anderson, Craig S., Thang-Nguyen, Huy, Gommans, John, Yi, Qilong, Murray, Veronica, Herbert, Robert, Carter, Gregory, Donnan, Geoffrey A., Nguyen, Huy-Thang, Li, Qiang, Bompoint, Severine, Barrett, Sarah, Claxton, Anne, O’Dea, Julia, Tang, Michelle, Williams, Clare, Peterson, Shenae, Drummond, Christie, Hong, Uyen-Ha, My Le, Linh-Thi, Bich Ngo, Tram-Thi, Mai, Yen-Bao, Han, Huyen-Thanh, Truong, Nhu-Quynh, Nguyen, Huong-Thi, Ngo, Hai-Thanh, Nguyen, Thi Binh, Kieu Ha, Oanh-Thi, Huyen Nguyen, Trang-Le, Lindley, Richard I., New, Peter, Lee, Andrew, Tran, Thanh-Trung, Truc Mai Le, Loan-Tran, Vu Kieu, Thuy-Le, Nguyen, Sang-Van, Diem Nguyen, Thuy-Anh, Dang, Tam-Nhat, Truc Phan, Hanh-Thi, Ngoc Vo, Loan-Thi, Nguyen, Mai-Hue, Dang, Hanh-Cao, Tran, Hong-Thi, Cam Dam, Linh-Thi, Kim Ngo, Trinh-Thi, Thanh Pham, Thai-Nguyen, Pham, Binh-Nguyen, Thanh Dao, Nha-Thi, Bich Nguyen, Huong-Thi, Cam Le, Linh-Thi, Do, Chi-Minh, Huynh, Huy-Quoc, Tran, Giau-Thi Kim, Le, Oanh-Thi, Khanh Tran, Ly-Thi, Duong, Chinh-Dinh, Kieu, Duong-Van, Le, Na, Nguyen, Hoa-Ngoc, Le, Binh-Van, Nguyen, Long-Thanh, Nguyen, Long-Van, Dinh, Tuan-Quoc, Vo, Tan-Van, Bui, Tram-Ngoc, To Hoang, Uyen-Thi, Bich Nguyen, Hien-Thi, Thu Nguyen, Ha-Thi, Lam, Nga-Thuy, Le, Khanh-Kim, Trinh, Phuong-Thanh, Huynh, Hop-Quang, Thu Nguyen, Thao-Thi, Lu, Huyen-Ngoc, Pham, Tham-Hong, Nguyen, Sam-Hoanh, Le, Ninh-Hong, Nguyen, Giang-Truong, Doan, Bich-Thi, Pham, Sung-Phuoc, Luong, Duong-Huu, Mai, Ha-Van, Tran, Thuc-Van, Do, Phuong-Thi, Le, Hoai-Thi, Nguyen, Chi-Van, Nguyen, Phuong-Doan, Mai, Ton-Duy, Dao, Phuong-Viet, Nguyen, Dung-Tien, Khuong, Dai-Quoc, Vuong, Trung-Xuan, Vu, Lan-Tuong, Ngo, Ngoc-Duc, Dang, Hanh-Hong, Truong, Phuong-Thai, Le, Ngan-Thi, Hoang, Hoa-Van, Do, Chung-Quang, Nguyen, Minh-Thao, Dam, Anh-Hai, Le, Quynh-Nhu, Nguyen, Ngoc-Hoang, Nguyen, Tuyen-Van, Le, Toan-Dinh, Hai Dinh, Ha-Thi, Pham, Cuong–Van, Ngoc Thach, Khanh-Thi, Nguyen, Linh-Hai, Nguyen, Loan-Thi, Le, Vien-Chi, Tran, Phuong-Hong, Nguyen, Tai-Anh, Le, Tuan-Van, Truong, Luyen-Van, Bui, Tue-Chau, Huynh, Ngoc-Xuan, Dinh, Lap-Van, Pham, An-Gia, Huyen Le, Trang-Thi, Nguyen, Vy-Tuong, Nguyen, Yen-Hai, Nguyen, Thang-Ba, Thai, Huy, Ngoc Pham, Quyen-Thi, Dao, Khoa-Duy, Bao Pham, Quoc-Nguyen, Huyen Dang, Thuong-Thi, To Dinh, Huong-Huynh, Tong, Trang-Mai, Vu, Thuy-Thi, Le, Si-Tri, Tran, Tai-Ngoc, Tran, Phuong-Hoai, Nhu Dinh, Ngoc-Thuy, Nguyen, Binh-Thanh, Do, Vinh-Phuong, Nguyen, Anh-Ngoc, Thanh Nguyen, Binh-Thi, Blacker, David, Bunce, Lindsey, Tan, Ai Ling, Ghia, Darshan, Edmonds, Gillian, O’Loughlin, Nicole, Ewing, Megan, Whittaker, Kerri-Ann, Deane, Lorralee, Gawarikar, Yash, Jones, Brett, Lopez, Maria, Nagesh, Koushik, Siracusa, Emma, Davis, Stephen, McDonald, Amy, Tsoleridis, Jess, McCoy, Rachael, Jackson, David, Silver, Gab, Bates, Timothy R., Boudville, Amanda, Southwell, Lynda, Cordato, Dennis, McDougall, Alan J., Cappelen-Smith, Cecilia, Calic, Zeljka, Askar, Shabeel, Cheng, Qi, Kumar, Raymond, Geraghty, Richard, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, McLennan, Cassandra, Sahathevan, Ramesh, Hair, Casey, Levy, Stanley, Macdonald, Beverley, Nham, Benjamin, Rigney, Louise, Nathani, Dev, Gopinath, Sumana, Patel, Vishal, Mamun, Abul, Trewin, Benjamin, Phua, Chun, Choong, Ho, Tarrant, Lauren, Boyle, Kerry, Hewitt, Luisa, Hourn, Monique, Masterson, Amanda, Oakley, Kim, Ruddell, Karen, Sanctuary, Colette, Veitch, Kimberley, Burdusel, Camelia, Lee, Lina, Cheuk, Gary, Christley, Jeremy, Hartwell, Tabitha, Davenport, Craig, Hickey, Kate, Robertson, Rosanna, Carr, Michelle, Akbari, Sam, Coyle, Hannah, O’Neill, Megan, Redpath, Cameron, Roberts, Caroline, Tabesh, Marjan, Withiel, Toni, Abeysuriya, Kapila, Granger, Andrew, Abraham, Angela, Chua, Chermaine, Nguyen, Dung Do, Surendran, Vathani, Daines, Melissa, Shivlal, David, Latif, Mudassar, Mughal, Noreen, Morgan, Patricia, Krause, Martin, Priglinger, Miriam, Shandiz, Ehsan E., Day, Susan, Kho, Lay, Pollack, Michael, Dunne, Judith, Baines, Helen, Rees, Merridie, White, Jenni, Withanage, Aicuratiya, Delcourt, Candice, Carcel, Cheryl, Malavera, Alejandra, Kunchok, Amy, Ray, Elizabeth, Pepper, Elizabeth, Duckett, Emily, Ormond, Sally, Moey, Andrew, Kleinig, Timothy, Maxwell, Vanessa, Baldwin, Chantal, Vallat, Wilson, Field, Deborah, Markus, Romesh, Page, Kirsty, Wheelwright, Danielle, Bolitho, Sam, Faux, Steven, Sangvatanakul, Fix, Brown, Alexis, Walker, Susan, Massey, Jennifer, Hayes, Hillary, Katrak, Pesi, Winker, Annie, Zagami, Alessandro, Bailey, Alanah, Mccormack, Sarah, Murray, Andrew, Rollason, Mark, Taylor, Christopher, O’Rourke, Fintan, Kuang, Ye Min, Burnet, Heike, Liu, Yvonne, Wu, Aileen, Ramirez, Diana, Wijeratne, Tissa, Celestino, Sherisse, Low, Essie, Chen, Cynthia, Bergqvist, Jennifer, Evans, Andrew, Leung, Queenie, Jude, Martin, McQueen, Rachael, Mohr, Katherine, Kernaghan, Latitia, Stockle, Paul, Tan, Boon L., Laubscher, Sara, Schmid, Diana, Spooner, Melissa, Lallu, Bhavesh, Pepperell, Bronwen, Chalissery, John, Mahawish, Karim, DeCaigney, Susan, Broughton, Paula, Knight, Karen, Duque, Veronica, McNaughton, Harry, Lanford, Jeremy, Fu, Vivian, Wong, Lai-Kin, Hankey, Graeme J., Hackett, Maree, Almeida, Osvaldo P., Flicker, Leon, Mead, Gillian E., Dennis, Martin S., Etherton-Beer, Christopher, Ford, Andrew H., Billot, Laurent, Jan, Stephen, Lung, Thomas, Lundström, Erik, Sunnerhagen, Katharina S., Anderson, Craig S., Thang-Nguyen, Huy, Gommans, John, Yi, Qilong, Murray, Veronica, Herbert, Robert, Carter, Gregory, Donnan, Geoffrey A., Nguyen, Huy-Thang, Li, Qiang, Bompoint, Severine, Barrett, Sarah, Claxton, Anne, O’Dea, Julia, Tang, Michelle, Williams, Clare, Peterson, Shenae, Drummond, Christie, Hong, Uyen-Ha, My Le, Linh-Thi, Bich Ngo, Tram-Thi, Mai, Yen-Bao, Han, Huyen-Thanh, Truong, Nhu-Quynh, Nguyen, Huong-Thi, Ngo, Hai-Thanh, Nguyen, Thi Binh, Kieu Ha, Oanh-Thi, Huyen Nguyen, Trang-Le, Lindley, Richard I., New, Peter, Lee, Andrew, Tran, Thanh-Trung, Truc Mai Le, Loan-Tran, Vu Kieu, Thuy-Le, Nguyen, Sang-Van, Diem Nguyen, Thuy-Anh, Dang, Tam-Nhat, Truc Phan, Hanh-Thi, Ngoc Vo, Loan-Thi, Nguyen, Mai-Hue, Dang, Hanh-Cao, Tran, Hong-Thi, Cam Dam, Linh-Thi, Kim Ngo, Trinh-Thi, Thanh Pham, Thai-Nguyen, Pham, Binh-Nguyen, Thanh Dao, Nha-Thi, Bich Nguyen, Huong-Thi, Cam Le, Linh-Thi, Do, Chi-Minh, Huynh, Huy-Quoc, Tran, Giau-Thi Kim, Le, Oanh-Thi, Khanh Tran, Ly-Thi, Duong, Chinh-Dinh, Kieu, Duong-Van, Le, Na, Nguyen, Hoa-Ngoc, Le, Binh-Van, Nguyen, Long-Thanh, Nguyen, Long-Van, Dinh, Tuan-Quoc, Vo, Tan-Van, Bui, Tram-Ngoc, To Hoang, Uyen-Thi, Bich Nguyen, Hien-Thi, Thu Nguyen, Ha-Thi, Lam, Nga-Thuy, Le, Khanh-Kim, Trinh, Phuong-Thanh, Huynh, Hop-Quang, Thu Nguyen, Thao-Thi, Lu, Huyen-Ngoc, Pham, Tham-Hong, Nguyen, Sam-Hoanh, Le, Ninh-Hong, Nguyen, Giang-Truong, Doan, Bich-Thi, Pham, Sung-Phuoc, Luong, Duong-Huu, Mai, Ha-Van, Tran, Thuc-Van, Do, Phuong-Thi, Le, Hoai-Thi, Nguyen, Chi-Van, Nguyen, Phuong-Doan, Mai, Ton-Duy, Dao, Phuong-Viet, Nguyen, Dung-Tien, Khuong, Dai-Quoc, Vuong, Trung-Xuan, Vu, Lan-Tuong, Ngo, Ngoc-Duc, Dang, Hanh-Hong, Truong, Phuong-Thai, Le, Ngan-Thi, Hoang, Hoa-Van, Do, Chung-Quang, Nguyen, Minh-Thao, Dam, Anh-Hai, Le, Quynh-Nhu, Nguyen, Ngoc-Hoang, Nguyen, Tuyen-Van, Le, Toan-Dinh, Hai Dinh, Ha-Thi, Pham, Cuong–Van, Ngoc Thach, Khanh-Thi, Nguyen, Linh-Hai, Nguyen, Loan-Thi, Le, Vien-Chi, Tran, Phuong-Hong, Nguyen, Tai-Anh, Le, Tuan-Van, Truong, Luyen-Van, Bui, Tue-Chau, Huynh, Ngoc-Xuan, Dinh, Lap-Van, Pham, An-Gia, Huyen Le, Trang-Thi, Nguyen, Vy-Tuong, Nguyen, Yen-Hai, Nguyen, Thang-Ba, Thai, Huy, Ngoc Pham, Quyen-Thi, Dao, Khoa-Duy, Bao Pham, Quoc-Nguyen, Huyen Dang, Thuong-Thi, To Dinh, Huong-Huynh, Tong, Trang-Mai, Vu, Thuy-Thi, Le, Si-Tri, Tran, Tai-Ngoc, Tran, Phuong-Hoai, Nhu Dinh, Ngoc-Thuy, Nguyen, Binh-Thanh, Do, Vinh-Phuong, Nguyen, Anh-Ngoc, Thanh Nguyen, Binh-Thi, Blacker, David, Bunce, Lindsey, Tan, Ai Ling, Ghia, Darshan, Edmonds, Gillian, O’Loughlin, Nicole, Ewing, Megan, Whittaker, Kerri-Ann, Deane, Lorralee, Gawarikar, Yash, Jones, Brett, Lopez, Maria, Nagesh, Koushik, Siracusa, Emma, Davis, Stephen, McDonald, Amy, Tsoleridis, Jess, McCoy, Rachael, Jackson, David, Silver, Gab, Bates, Timothy R., Boudville, Amanda, Southwell, Lynda, Cordato, Dennis, McDougall, Alan J., Cappelen-Smith, Cecilia, Calic, Zeljka, Askar, Shabeel, Cheng, Qi, Kumar, Raymond, Geraghty, Richard, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, McLennan, Cassandra, Sahathevan, Ramesh, Hair, Casey, Levy, Stanley, Macdonald, Beverley, Nham, Benjamin, Rigney, Louise, Nathani, Dev, Gopinath, Sumana, Patel, Vishal, Mamun, Abul, Trewin, Benjamin, Phua, Chun, Choong, Ho, Tarrant, Lauren, Boyle, Kerry, Hewitt, Luisa, Hourn, Monique, Masterson, Amanda, Oakley, Kim, Ruddell, Karen, Sanctuary, Colette, Veitch, Kimberley, Burdusel, Camelia, Lee, Lina, Cheuk, Gary, Christley, Jeremy, Hartwell, Tabitha, Davenport, Craig, Hickey, Kate, Robertson, Rosanna, Carr, Michelle, Akbari, Sam, Coyle, Hannah, O’Neill, Megan, Redpath, Cameron, Roberts, Caroline, Tabesh, Marjan, Withiel, Toni, Abeysuriya, Kapila, Granger, Andrew, Abraham, Angela, Chua, Chermaine, Nguyen, Dung Do, Surendran, Vathani, Daines, Melissa, Shivlal, David, Latif, Mudassar, Mughal, Noreen, Morgan, Patricia, Krause, Martin, Priglinger, Miriam, Shandiz, Ehsan E., Day, Susan, Kho, Lay, Pollack, Michael, Dunne, Judith, Baines, Helen, Rees, Merridie, White, Jenni, Withanage, Aicuratiya, Delcourt, Candice, Carcel, Cheryl, Malavera, Alejandra, Kunchok, Amy, Ray, Elizabeth, Pepper, Elizabeth, Duckett, Emily, Ormond, Sally, Moey, Andrew, Kleinig, Timothy, Maxwell, Vanessa, Baldwin, Chantal, Vallat, Wilson, Field, Deborah, Markus, Romesh, Page, Kirsty, Wheelwright, Danielle, Bolitho, Sam, Faux, Steven, Sangvatanakul, Fix, Brown, Alexis, Walker, Susan, Massey, Jennifer, Hayes, Hillary, Katrak, Pesi, Winker, Annie, Zagami, Alessandro, Bailey, Alanah, Mccormack, Sarah, Murray, Andrew, Rollason, Mark, Taylor, Christopher, O’Rourke, Fintan, Kuang, Ye Min, Burnet, Heike, Liu, Yvonne, Wu, Aileen, Ramirez, Diana, Wijeratne, Tissa, Celestino, Sherisse, Low, Essie, Chen, Cynthia, Bergqvist, Jennifer, Evans, Andrew, Leung, Queenie, Jude, Martin, McQueen, Rachael, Mohr, Katherine, Kernaghan, Latitia, Stockle, Paul, Tan, Boon L., Laubscher, Sara, Schmid, Diana, Spooner, Melissa, Lallu, Bhavesh, Pepperell, Bronwen, Chalissery, John, Mahawish, Karim, DeCaigney, Susan, Broughton, Paula, Knight, Karen, Duque, Veronica, McNaughton, Harry, Lanford, Jeremy, Fu, Vivian, and Wong, Lai-Kin

Abstract

Background and Purpose: The AFFINITY trial (Assessment of Fluoxetine in Stroke Recovery) reported that oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and seizures. After trial medication was ceased at 6 months, survivors were followed to 12 months post-randomization. This preplanned secondary analysis aimed to determine any sustained or delayed effects of fluoxetine at 12 months post-randomization. Methods: AFFINITY was a randomized, parallel-group, double-blind, placebo-controlled trial in adults (n=1280) with a clinical diagnosis of stroke in the previous 2 to 15 days and persisting neurological deficit who were recruited at 43 hospital stroke units in Australia (n=29), New Zealand (4), and Vietnam (10) between 2013 and 2019. Participants were randomized to oral fluoxetine 20 mg once daily (n=642) or matching placebo (n=638) for 6 months and followed until 12 months after randomization. The primary outcome was function, measured by the modified Rankin Scale, at 6 months. Secondary outcomes for these analyses included measures of the modified Rankin Scale, mood, cognition, overall health status, fatigue, health-related quality of life, and safety at 12 months. Results: Adherence to trial medication was for a mean 167 (SD 48) days and similar between randomized groups. At 12 months, the distribution of modified Rankin Scale categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio, 0.93 [95% CI, 0.76–1.14]; P =0.46). Compared with placebo, patients allocated fluoxetine had fewer recurrent ischemic strokes (14 [2.18%] versus 29 [4.55%]; P =0.02), and no longer had significantly more falls (27 [4.21%] versus 15 [2.35%]; P =0.08), bone fractures (23 [3.58%] versus 11 [1.72%]; P =0.05), or seizures (11 [1.71%] versus 8 [1.25%]; P =0.64) at 12 months. Conclusions: Fluoxetine 20 mg daily for 6 months after acute stroke had no delayed or sustained

Published
2021

31. WSO915144 Supplemental Material - Supplemental material for Taking Charge after Stroke: A randomized controlled trial of a person-centered, self-directed rehabilitation intervention

Author

Fu, Vivian, Weatherall, Mark, McPherson, Kathryn, Taylor, William, McRae, Anna, Thomson, Tom, Gommans, John, Green, Geoff, Matire Harwood, Annemarei Ranta, Hanger, Carl, Riley, Judith, and McNaughton, Harry

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, WSO915144 Supplemental Material for Taking Charge after Stroke: A randomized controlled trial of a person-centered, self-directed rehabilitation intervention by Vivian Fu, Mark Weatherall, Kathryn McPherson, William Taylor, Anna McRae, Tom Thomson, John Gommans, Geoff Green, Matire Harwood, Annemarei Ranta, Carl Hanger, Judith Riley and Harry McNaughton in International Journal of Stroke

Published
2020
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32. Extent and potential impact of hunting on migratory shorebirds in the Asia-Pacific

Author

Gallo-Cajiao, Eduardo, Morrison, Tiffany H, Woodworth, Bradley K, Lees, Alexander C, Naves, Liliana C, Yong, Ding Li, Choi, Chi-Yeung, Mundkur, Taej, Bird, Jeremy, Jain, Anuj, Klokov, Konstantin, Syroechkovskiy, Evgeny, Chowdhury, Sayam U, Fu, Vivian Wing Kan, Watson, James EM, Fuller, Richard A, Gallo-Cajiao, Eduardo, Morrison, Tiffany H, Woodworth, Bradley K, Lees, Alexander C, Naves, Liliana C, Yong, Ding Li, Choi, Chi-Yeung, Mundkur, Taej, Bird, Jeremy, Jain, Anuj, Klokov, Konstantin, Syroechkovskiy, Evgeny, Chowdhury, Sayam U, Fu, Vivian Wing Kan, Watson, James EM, and Fuller, Richard A

Abstract

Harvesting has driven population declines of migratory species. In the East Asian-Australasian Flyway (EAAF), declines of migratory shorebirds have been largely attributed to habitat loss. However, despite concerns about hunting, no study has considered this potential threat at a flyway scale. We synthesised and analysed the current state of knowledge of hunting of migratory shorebirds in the EAAF to determine: (i) whether there is flyway-wide coordination for monitoring hunting; (ii) the temporal, spatial, and taxonomic extent of hunting; and (iii) the potential population-level effects. We conducted an exhaustive literature search, aggregated data considering uncertainty in different dimensions, and appraised hunting levels against sustainable harvest thresholds. We identified 138 references (i.e., peer-reviewed journal articles, book chapters, books, conference proceedings, technical reports, theses, and newsletters) as potential sources of records of hunting of migratory shorebirds of which we were able to obtain 107. We discovered a lack of coordinated monitoring of hunting, despite harvest being temporally, spatially, and taxonomically pervasive, including species of conservation concern. Past harvest levels of migratory shorebirds may have reached at least half of the flyway-wide sustainable thresholds in the EAAF. Despite our inability to assess current hunting levels and unambiguous population-level effects, it is evident that hunting has the potential to be an additional stressor on migratory shorebird populations interplaying with habitat loss. We therefore highlight the need to develop a coordinated monitoring system of hunting at a flyway scale, as past levels of take are likely to have been unsustainable, hunting still occurs, and the current thresholds for sustainable harvest have become lower as a result of declines in shorebird populations.

Published
2020

35. The effect of the Take Charge intervention on mood, motivation, activation and risk factor management: Analysis of secondary data from the Taking Charge after Stroke (TaCAS) trial

Author

McNaughton, Harry, primary, Weatherall, Mark, additional, McPherson, Kathryn, additional, Fu, Vivian, additional, Taylor, William J, additional, McRae, Anna, additional, Thomson, Tom, additional, Gommans, John, additional, Green, Geoff, additional, Harwood, Matire, additional, Ranta, Annemarei, additional, Hanger, Carl, additional, and Riley, Judith, additional

Published
2021
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38. Conserving migratory waterbirds and the coastal zone: the future of South-east Asia's intertidal wetlands.

Author

Yong, Ding Li, Kee, Jing Ying, Aung, Pyae Phyo, Jain, Anuj, Yeap, Chin-Aik, Au, Nyat Jun, Jearwattanakanok, Ayuwat, Lim, Kim Keang, Yu, Yat-Tung, Fu, Vivian W. K., Insua-Cao, Paul, Sawa, Yusuke, Crosby, Mike, Chan, Simba, and Crockford, Nicola J.

Subjects
WATER birds, COASTS, COASTAL wetlands, WETLANDS, IMPORTANT bird areas, MIGRATORY animals, TIDAL flats, WETLAND soils
Abstract

South-east Asia's diverse coastal wetlands, which span natural mudflats and mangroves to man-made salt pans, offer critical habitat for many migratory waterbird species in the East Asian–Australasian Flyway. Species dependent on these wetlands include nearly the entire population of the Critically Endangered spoon-billed sandpiper Calidris pygmaea and the Endangered spotted greenshank Tringa guttifer, and significant populations of several other globally threatened and declining species. Presently, more than 50 coastal Important Bird and Biodiversity Areas (IBAs) in the region (7.4% of all South-east Asian IBAs) support at least one threatened migratory species. However, recent studies continue to reveal major knowledge gaps on the distribution of migratory waterbirds and important wetland sites along South-east Asia's vast coastline, including undiscovered and potential IBAs. Alongside this, there are critical gaps in the representation of coastal wetlands across the protected area networks of many countries in this region (e.g. Viet Nam, Indonesia, Malaysia), hindering effective conservation. Although a better understanding of the value of coastal wetlands to people and their importance to migratory species is necessary, governments and other stakeholders need to do more to strengthen the conservation of these ecosystems by improving protected area coverage, habitat restoration, and coastal governance and management. This must be underpinned by the judicious use of evidence-based approaches, including satellite-tracking of migratory birds, ecological research and ground surveys. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Extent and potential impact of hunting on migratory shorebirds in the Asia-Pacific

Author

Gallo-Cajiao, Eduardo, primary, Morrison, Tiffany H., additional, Woodworth, Bradley K., additional, Lees, Alexander C., additional, Naves, Liliana C., additional, Yong, Ding Li, additional, Choi, Chi-Yeung, additional, Mundkur, Taej, additional, Bird, Jeremy, additional, Jain, Anuj, additional, Klokov, Konstantin, additional, Syroechkovskiy, Evgeny, additional, Chowdhury, Sayam U., additional, Fu, Vivian Wing Kan, additional, Watson, James E.M., additional, and Fuller, Richard A., additional

Published
2020
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41. Taking Charge after Stroke: A randomized controlled trial of a person-centered, self-directed rehabilitation intervention

Author

Fu, Vivian, primary, Weatherall, Mark, additional, McPherson, Kathryn, additional, Taylor, William, additional, McRae, Anna, additional, Thomson, Tom, additional, Gommans, John, additional, Green, Geoff, additional, Harwood, Matire, additional, Ranta, Annemarei, additional, Hanger, Carl, additional, Riley, Judith, additional, and McNaughton, Harry, additional

Published
2020
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44. Economic analysis of the 'Take Charge' intervention for people following stroke: Results from a randomised trial.

Author

Te Ao, Braden, Harwood, Matire, Fu, Vivian, Weatherall, Mark, McPherson, Kathryn, Taylor, William J, McRae, Anna, Thomson, Tom, Gommans, John, Green, Geoff, Ranta, Annemarei, Hanger, Carl, Riley, Judith, and McNaughton, Harry

Subjects
CONFIDENCE intervals, COST control, HEALTH outcome assessment, RANDOMIZED controlled trials, COST effectiveness, STROKE rehabilitation, RESEARCH funding, QUESTIONNAIRES, DESCRIPTIVE statistics, ECONOMIC aspects of diseases, DATA analysis software, BARTHEL Index, STATISTICAL sampling, HEALTH self-care, QUALITY-adjusted life years
Abstract

Objective: To undertake an economic analysis of the Take Charge intervention as part of the Taking Charge after Stroke (TaCAS) study. Design: An open, parallel-group, randomised trial comparing active and control interventions with blinded outcome assessment Setting: Community. Participants: Adults (n = 400) discharged to community, non-institutional living following acute stroke. Interventions: The Take Charge intervention, a strengths based, self-directed rehabilitation intervention, in two doses (one or two sessions), and a control intervention (no Take Charge sessions). Measures: The cost per quality-adjusted life year (QALY) saved for the period between randomisation (always post hospital discharge) and 12 months following acute stroke. QALYs were calculated from the EuroQol-5D-5L. Costs of stroke-related and non-health care were obtained by questionnaire, hospital records and the New Zealand Ministry of Health. Results: One-year post hospital discharge cost of care was mean (95% CI) $US4706 (3758–6014) for the Take Charge intervention group and $6118 (4350–8005) for control, mean (95% CI) difference $ −1412 (−3553 to +729). Health utility scores were mean (95% CI) 0.75 (0.73–0.77) for Take Charge and 0.71 (0.67–0.75) for control, mean (95% CI) difference 0.04 (0.0–0.08). Cost per QALY gained for the Take Charge intervention was $US −35,296 (=£ −25,524, € −30,019). Sensitivity analyses confirm Take Charge is cost-effective, even at a very low willingness-to-pay threshold. With a threshold of $US5000 per QALY, the probability that Take Charge is cost-effective is 99%. Conclusion: Take Charge is cost-effective and probably cost saving. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Planned Oocyte Cryopreservation: Outcomes, Motivations, and Involvement of Primary Health Care Providers.

Author

Yee, Samantha, Lipton, Nechama J., Fu, Vivian, Goodman, Carly V., and Librach, Clifford

Subjects
OCCUPATIONAL roles, ACADEMIC medical centers, OVUM, MOTIVATION (Psychology), PRIMARY health care, SURVEYS, TREATMENT effectiveness, FERTILITY preservation, DECISION making, QUESTIONNAIRES, FERTILIZATION in vitro, PATIENT-professional relations, CRYOPRESERVATION of organs, tissues, etc., EMAIL
Abstract

Background: With improvements in oocyte cryopreservation and widespread delays in childbearing, planned oocyte cryopreservation (POC) has become an increasingly attractive option. This study aimed to (1) review POC cycle outcomes at an academic in vitro fertilization (IVF) center and (2) examine POC users' motivations for pursuing POC, fertility knowledge, and the involvement of their primary health care providers (PHP). Materials and Methods: POC cycle outcomes were collected from IVF records of the 224 women who underwent ≥1 cycle from 2012 to 2018. The 198 who were reachable by e-mail were invited to complete an online survey. The study was approved by the University of Toronto Research Ethics Board (No. 32951). Results: Mean age of the 224 women at first cycle was 36.4 (range: 25–42), with a significant decrease in anti-Müllerian hormone level (p = 0.001) and mean number of oocytes retrieved (p = 0.006) and cryopreserved per cycle (p = 0.042) with increasing age. From those invited for survey participation, 98 (49.5%) questionnaires were returned, with 86 evaluable. Majority of respondents were Caucasian (66%), single (93%), and earned a gross annual income of >$70,000 (74%). Strongest motivation for pursuing POC was concern about age-related fertility decline in the absence of a partner. Respondents' annual income was positively correlated with the number of completed cycles (p = 0.032). Half the respondents correctly identified age of onset of marked fertility decline as ≥35 years. In only 19% of cases was the conversation PHP initiated, and 29% never discussed POC with their PHP. Conclusions: More than 50% of women underwent POC at an age when fertility has begun to markedly decline. It is important for PHPs to identify and discuss POC with appropriate patients and offer accurate preliminary information and timely referrals for those interested in exploring this option. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Taking Charge After Stroke: A novel, community-based intervention to improve the lives of people with stroke

Author

McNaughton, Harry, Beasley, Richard, Miller, John, Fu, Vivian, McNaughton, Harry, Beasley, Richard, Miller, John, and Fu, Vivian

Abstract

Background and aims: Stroke is the third leading cause of disability worldwide. Despite the recent development of hyper-acute therapies for stroke, outcomes for people with stroke and types of rehabilitation interventions have remained unchanged. Rehabilitation in New Zealand is largely therapy-based and uses goal setting as a main component, but evidence for effectiveness of these methods is weak. Attempts to enhance the effects of rehabilitation using a stroke liaison officer or a caregiver to lead rehabilitation at home have had no effect on outcomes. However, self-management interventions have shown some promise. The Take Charge session is a novel, community-based, self-management intervention, which was shown to significantly improve both independence and health-related quality of life at 12 months following stroke in Māori and Pacific New Zealanders. We formalised the components of the Take Charge session, based upon Self Determination Theory and qualitative research about the importance of Taking Charge in recovery. This allowed us to retest the intervention in a different population of people with stroke. We hypothesised that: (1) the beneficial effect of the Take Charge session would be reproducible in a larger cohort of non-Māori, non-Pacific people with stroke, and (2) that two Take Charge sessions would have a greater positive effect on health-related quality of life than one alone. Methods: We randomised 400 people within 16 weeks of acute stroke who had been discharged to community living at seven centres in New Zealand to either a single Take Charge session (TCS 1, n = 132), two Take Charge sessions (TCS 2, n = 138), or a control intervention (n = 130). The primary outcome was the Physical Component Summary score (PCS) of the Short Form 36 (SF-36) at 12 months following index stroke, comparing any Take Charge session exposure to control. Secondary outcomes included the PCS of the Short Form 12 (SF-12) at six months, participation measured by the Frenc

Published
2019

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