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Background: Patients with sub-acute cerebral venous sinus thrombosis experience (SA.CVST) severe symptoms compared to two other venous sinus-related diseases, including chronic cerebral venous sinus thrombosis (C.CVST) and idiopathic intracranial hypertension (IIH). Objective: This study aimed to determine whether the different immune reactions in different venous sinuses are related. Methods: Stagnant blood in the cerebral venous sinuses was extracted by passing a microcatheter and CD14 -positive cells were sorted by magnetic beads and subjected to RNA-seq sequencing. Results: Compared to patients with IIH, 128 genes were significantly down-regulated and 373 genes were significantly up-regulated in the sub-acute CVST samples. The functions of these genes were mainly focused on "immune response", "T cell activation" and "plasma membrane". Gene Set Enrichment Analysis (GSEA) showed T cell survival and activation-related function significantly unregulated in sub-acute CVST. On the other hand, there were 366 genes down-regulated in chronic CVST and 75 genes up-regulated in chronic CVST. In functional annotation, these differently expressed genes were enriched in the "extracellular region", "chemokine-mediated signaling pathway" and "immune response". GSEA analysis confirmed that chemokine-related functions were all up-regulated in sub-acute CVST and monocyte-macrophage adhesion functions were also significantly up-regulated. Conclusion: This study suggested the CD14 -positive created an activated immune response in sub-acute CVST. [ABSTRACT FROM AUTHOR]

A weld inspection manipulator for intersected pipes was investigated. According to the requirement of motion constraints by Cartesian trajectory, a multi-object model based on the criteria of global minimal energy optimization for the manipulator was established, in which the flexible mounting height is also considered. The model encapsulates the issues of obstacle avoidance, trajectory accuracy of end-effector, dynamic constrains and minimal energy optimization criterion based on redundancy. The stochastic search strategy for the problem of minimal energy optimization was also proposed using genetic algorithm. This work was demonstrated by the results of simulation. It also has a wide range of application for other industry manipulators. [ABSTRACT FROM AUTHOR]

Measuring principle of the thickness and defect of magnetic materials was given. Based on the principle, an experimental set-up with a designed sensor was built. Through the sensor character experiments, some conclusions were obtained: the presence of magnetism concentrating components, shorter lift off distance, higher excitation current, more coil turns, less spacing between arrayed sensors and fewer magnetization time are all help to increase the sensor sensitivity. The influence of environment temperature to the measurement errors is less notable. The defect can be qualitatively determined easily, but it is different to give the quantificational parameters. The sensor should be calibrated again when different material objects are tested. [ABSTRACT FROM AUTHOR]