68 results on '"Fu, Yu-Lin"'
Search Results
2. A new substrate equalization method for optimizing the influent conditions and fluid flow patterns of a multifed upflow anaerobic sludge blanket reactor with mature anammox granules
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Xing, Bao-Shan, Tang, Xi-Fang, Li, Ling-Hu, Fu, Yu-Lin, Liu, Jia-Yi, Wang, Ya-Ge, Sun, Xin-Xin, Li, Yu-You, Chen, Rong, and Jin, Ren-Cun
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- 2024
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3. Diagnosis of Alzheimer's Disease Using Convolutional Neural Network With Select Slices by Landmark on Hippocampus in MRI Images.
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Yori Pusparani, Chih-Yang Lin, Yih-Kuen Jan, Fu-Yu Lin, Ben-Yi Liau, Peter Ardhianto, Isack Farady, John Sahaya Rani Alex, Jeetashree Aparajeeta, Wen-Hung Chao, and Chi-Wen Lung
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- 2023
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4. An approach to the diagnosis of lumbar disc herniation using deep learning models
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Ardha Ardea Prisilla, Yue Leon Guo, Yih-Kuen Jan, Chih-Yang Lin, Fu-Yu Lin, Ben-Yi Liau, Jen-Yung Tsai, Peter Ardhianto, Yori Pusparani, and Chi-Wen Lung
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augmentation ,automatic detection ,low back pain ,MRI ,YOLO models ,Biotechnology ,TP248.13-248.65 - Abstract
Background: In magnetic resonance imaging (MRI), lumbar disc herniation (LDH) detection is challenging due to the various shapes, sizes, angles, and regions associated with bulges, protrusions, extrusions, and sequestrations. Lumbar abnormalities in MRI can be detected automatically by using deep learning methods. As deep learning models gain recognition, they may assist in diagnosing LDH with MRI images and provide initial interpretation in clinical settings. YOU ONLY LOOK ONCE (YOLO) model series are often used to train deep learning algorithms for real-time biomedical image detection and prediction. This study aims to confirm which YOLO models (YOLOv5, YOLOv6, and YOLOv7) perform well in detecting LDH in different regions of the lumbar intervertebral disc.Materials and methods: The methodology involves several steps, including converting DICOM images to JPEG, reviewing and selecting MRI slices for labeling and augmentation using ROBOFLOW, and constructing YOLOv5x, YOLOv6, and YOLOv7 models based on the dataset. The training dataset was combined with the radiologist’s labeling and annotation, and then the deep learning models were trained using the training/validation dataset.Results: Our result showed that the 550-dataset with augmentation (AUG) or without augmentation (non-AUG) in YOLOv5x generates satisfactory training performance in LDH detection. The AUG dataset overall performance provides slightly higher accuracy than the non-AUG. YOLOv5x showed the highest performance with 89.30% mAP compared to YOLOv6, and YOLOv7. Also, YOLOv5x in non-AUG dataset showed the balance LDH region detections in L2-L3, L3-L4, L4-L5, and L5-S1 with above 90%. And this illustrates the competitiveness of using non-AUG dataset to detect LDH.Conclusion: Using YOLOv5x and the 550 augmented dataset, LDH can be detected with promising both in non-AUG and AUG dataset. By utilizing the most appropriate YOLO model, clinicians have a greater chance of diagnosing LDH early and preventing adverse effects for their patients.
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- 2023
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5. A new substrate equalization method for optimizing the influent conditions and fluid flow patterns of a multifed upflow anaerobic sludge blanket (MUASB) reactor with mature anammox granules
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Xing, Bao-Shan, primary, Tang, Xi-Fang, additional, Li, Ling-Hu, additional, Fu, Yu-Lin, additional, Liu, Jia-Yi, additional, Wang, Ya-Ge, additional, Sun, Xin-Xin, additional, Li, Yu-You, additional, Chen, Rong, additional, and Jin, Ren-Cun, additional
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- 2024
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6. Diameter Reduction Determined Through Carotid Ultrasound Associated With Cardiovascular and All‐Cause Mortality: A Single‐Center Experience of 38 201 Consecutive Patients in Taiwan
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Pei‐Chun Chen, Fu‐Yu Lin, Han‐Chun Huang, Hsiu‐Yin Chiang, Shih‐Ni Chang, Pei‐Shan Chen, Yuh‐Cherng Guo, Pei‐Shan Liao, Yu‐Chyn Wei, and Chin‐Chi Kuo
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atherosclerosis ,carotid artery diameter ,electronic health records ,mortality ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Few studies have evaluated the prognostic significance of diameter‐based carotid sonographic measurements for mortality. We investigated whether a reduction in diameter of different carotid anatomical segments is associated with cardiovascular and all‐cause mortality in a hospital‐based cohort with universal health care. Methods and Results We conducted a retrospective cohort study of 38 201 patients who underwent carotid duplex ultrasound at a medical center in Taiwan. Carotid sonographic parameters were the diameter reduction percentage in carotid bifurcation, the internal carotid artery, the common carotid artery, and the external carotid artery and the overall carotid atherosclerotic burden score, determined by summing the scores from all segments. The vital status was ascertained by linking data to National Death Registry until 2017. During a median follow‐up of 4.2 years, 5644 participants died, with 1719 deaths attributable to cardiovascular diseases. The multivariable‐adjusted hazard ratios (HRs; 95% CIs) for cardiovascular mortality were 1.33 (1.16‒1.53), 1.58 (1.361.84), and 1.89 (1.58, 2.26) for participants with 30% to
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- 2021
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7. Meta-analysis of randomized controlled studies of closed incisional negative pressure wound therapy versus standard wound dressing in the prevention of surgical site infections for patients undergoing surgeries for lower extremity fractures
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Fu-Yu Lin, Tomas Kempny, Martin Knoz, and Hsu-Tang Cheng
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Surgery - Published
- 2023
8. Bereitschaftspotential in Multiple System Atrophy
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Yi-Chien Yang, Fang-Tzu Chang, Jui-Cheng Chen, Chon-Haw Tsai, Fu-Yu Lin, and Ming-Kuei Lu
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Bereitschaftspotential ,movement-related cortical potential ,multiple system atrophy ,parkinsonism ,neurodegenerative disorder ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective: Multiple system atrophy (MSA) is a neurodegenerative disorder manifesting as parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is categorized into MSA with predominant parkinsonism (MSA-P) and into MSA with predominant cerebellar ataxia (MSA-C). The pathophysiology of motor control circuitry involvement in MSA subtype is unclear. Bereitschaftspotential (BP) is a feasible clinical tool to measure electroencephalographic activity prior to volitional motions. We recorded BP in patients with MSA-P and MSA-C to investigate their motor cortical preparation and activation for volitional movement.Methods: We included eight patients with MSA-P, eight patients with MSA-C, and eight age-matched healthy controls. BP was recorded during self-paced rapid wrist extension movements. The electroencephalographic epochs were time-locked to the electromyography onset of the voluntary wrist movements. The three groups were compared with respect to the mean amplitudes of early (1,500–500 ms before movement onset) and late (500–0 ms before movement onset) BP.Results: Mean early BP amplitude was non-significantly different between the three groups. Mean late BP amplitude in the two patient groups was significantly reduced in the parietal area contralateral to the movement side compared with that in the healthy control group. In addition, the late BP of the MSA-C group but not the MSA-P group was significantly reduced at the central parietal area compared with that of the healthy control group.Conclusions: Our findings suggest that patients with MSA exhibit motor cortical dysfunction in voluntary movement preparation and activation. The dysfunction can be practicably evaluated using late BP, which represents the cerebello-dentato-thalamo-cortical pathway.
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- 2021
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9. Three-year mortality in cryptococcal meningitis: Hyperglycemia predict unfavorable outcome.
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Sheng-Ta Tsai, Fu-Yu Lin, Pei-Shan Chen, Hsiu-Yin Chiang, and Chin-Chi Kuo
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Medicine ,Science - Abstract
Existing evidence revealed grave prognosis for cryptococcal meningitis (CM), particularly its short-term mortality. However, its long-term survival and prognostic factors remained unknown. This study investigated 3-year mortality and analyzed its predictive factors in patients with CM. This retrospective cohort study with 83 cerebrospinal fluid culture-confirmed CM patients was conducted at China Medical University Hospital from 2003 to 2016. The 3-year mortality rate in patients with CM was 54% (45 deaths among 83 patients). Advanced age, human immunodeficiency virus (HIV) seronegative state, low Glasgow Coma Scale score on admission, decreased hemoglobin and hyperglycemia on diagnosis were associated with 3-year mortality. After multivariate adjustment in the Cox proportional hazard model, only severe hyperglycemia (serum glucose ≥200 mg/dL) on diagnosis could predict 3-year mortality.
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- 2021
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10. Increased risk of overactive bladder in patients with idiopathic Parkinson's disease: Insight from a nationwide population-based cohort study.
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Fu-Yu Lin, Yi-Chien Yang, Cheng-Li Lin, and Lukas Jyuhn-Hsiarn Lee
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Medicine ,Science - Abstract
Idiopathic Parkinson's disease (IPD) is a progressive neurodegenerative disorder characterized by typical motor impairment. However, lower urinary tract symptoms, including urinary urgency or frequency, which are non-motor phenomena, occur frequently among patients with IPD. In this study, we assess the risk of overactive bladder (OAB) in patients with IPD.The National Health Insurance Research Database of Taiwan was used to identify patients with IPD (IPD cohort) and four-fold controls (non-IPD cohort) from 2000 to 2010. The non-IPD cohort was matched according to age, sex, and baseline comorbidities, including benign prostate hyperplasia, stress incontinence, diabetes, and cerebrovascular diseases. The occurrence of OAB was monitored until the end of 2011. Hazard ratios of OAB were estimated using Cox proportional hazards regression models.In total, 4,571 and 18,255 patients were included in IPD and non-IPD cohorts, respectively. Results showed a significantly higher overall incidence rate of OAB in the IPD cohort compared with the non-IPD cohort (14.5 vs. 6.37 per 10,000 person-years), with a 2.3-fold increased risk of OAB (95% confidence interval [CI] = 1.51-3.51) after controlling for benign prostate hyperplasia and stress incontinence. The mean follow-up period for the IPD cohort was 5.0 years. This cohort study showed that the cumulative incidence of OAB was 0.65% at the fifth year and 1.54% at the tenth year after IPD diagnosis; this risk was highest in the age group 65-74 years.This study reveals that IPD is independently associated with an increased risk of OAB in patients with IPD. The probability of OAB was 1.54% over a 10-year period after IPD diagnosis; the risk of OAB is considered to be age-dependent and most substantial in patients aged 65-74 years.
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- 2018
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11. Combination of Autologous Fat Grafting and Negative-Pressure Wound Therapy for the Treatment of Scalp Linear Scleroderma
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Min-Min Lee, Fu-Yu Lin, Ali Ahmadi, Maria Chicco, Hsu-Tang Cheng, and Plastic and Reconstructive Surgery and Hand Surgery
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medicine.medical_specialty ,integumentary system ,business.industry ,medicine.medical_treatment ,General Medicine ,Bone grafting ,Surgery ,Abdominal wall ,Lesion ,medicine.anatomical_structure ,Otorhinolaryngology ,Negative-pressure wound therapy ,Scalp ,medicine ,Linear Scleroderma ,sense organs ,medicine.symptom ,Localized Scleroderma ,business ,Tissue expansion - Abstract
Scalp linear scleroderma (LSc) is a subtype of localized scleroderma which typically affects young patients and which can be severely disfiguring. Traditional treatment options include bone grafting or tissue expansion. In this report, we present the case of a patient with scalp LSc successfully treated with scar release, autologous fat grafting, and negative-pressure wound therapy (NPWT). A 55-year-old female, with a history of craniectomy for a benign sellar tumor 10 years previously, developed LSc over the frontal scalp with exposure of titanium plates and screws. She was treated with removal of metalwork, scar release, autologous fat grafting from the abdominal wall and immediate application of NPWT. At 3-month postoperative follow-up, the appearance of the depressed lesion and of its margins had significantly improved. Our experience suggests that the combination of autologous fat grafting and NPWT is an effective treatment modality for scalp LSc.
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- 2021
12. H2O wash: a simple method toward eliminating discharge products and regenerating cathodes of Li–O2 batteries
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Iputera, Kevin, primary, Fu, Yu-Lin, additional, Li, Lidong, additional, Hu, Shu-Fen, additional, Wei, Da-Hua, additional, and Liu, Ru-Shi, additional
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- 2022
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13. Systematic review of negative pressure wound therapy for head and neck wounds with fistulas: Outcomes and complications
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Pin-Yi Huang, Hsu-Tang Cheng, and Fu-Yu Lin
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medicine.medical_specialty ,Reconstructive Surgeon ,Fistula ,medicine.medical_treatment ,MEDLINE ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Negative-pressure wound therapy ,medicine ,Humans ,030212 general & internal medicine ,Head and neck ,Adverse effect ,Wound Healing ,business.industry ,Soft tissue ,Original Articles ,Evidence-based medicine ,medicine.disease ,Surgery ,Treatment Outcome ,Wounds and Injuries ,business ,Head ,Neck ,Negative-Pressure Wound Therapy - Abstract
Fistula formation in head and neck wounds is considered one of the most challenging complications that a head and neck reconstructive surgeon may encounter. The current mainstay of treatment is aggressive surgical debridement followed by vascularised soft tissue coverage. Negative pressure wound therapy (NPWT) has been successfully used for the closure of complicated wounds for decades. This study analysed the outcomes and complications of NPWT in the management of head and neck wounds with fistulas. A systematic search of studies published between January 1966 and September 2019 was conducted using the PubMed, MEDLINE, EMBASE, and SCOPUS databases and using the following key words: "negative pressure wound therapy," "head and neck," and "fistula." We included human studies with abstract and full text available. Analysed endpoints were rate of fistula closure, follow-up duration, and complications if present. Nine retrospective case series (Level IV evidence) that collectively included 122 head and neck wounds with orocutaneous fistulas, pharyngocutaneous fistulas, and salivary contamination were examined. The number of patients included in each study ranged from 5 to 64. The mode of NPWT varied among the included studies, with most adopting a continuous pressure of -125 mm Hg. Mean durations of NPWT ranged from 3.7 to 23 days, and the reported fistula closure rate ranged from 78% to 100%. To achieve complete wound healing, six studies used additional procedures after stopping NPWT, including conventional wound dressings and vascularised tissue transfer. Information regarding follow up was provided in only three of the nine studies, where patients were followed for 5, 10, and 18 months. No serious adverse events were reported. NPWT for head and neck wounds with fistulas may be considered a safe treatment method that yields beneficial outcomes with a low risk of complications. The current data originated mainly from studies with low levels of evidence characterised by heterogeneity. Therefore, definitive recommendations based on these data cannot be offered. Additional high-quality trials are warranted to corroborate the findings of this systematic review.
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- 2019
14. H2O wash: a simple method toward eliminating discharge products and regenerating cathodes of Li–O2 batteries.
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Iputera, Kevin, Fu, Yu-Lin, Li, Lidong, Hu, Shu-Fen, Wei, Da-Hua, and Liu, Ru-Shi
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CATHODES , *ENERGY density , *STORAGE batteries , *ELECTRIC batteries , *LITHIUM-air batteries - Abstract
The development of air cathodes for Li–O2 batteries is extensively studied, but focus on recycling Li–O2 batteries is still limited. Usually, the final death of Li–O2 batteries is caused by the accumulation of discharge products (Li2O2) on air cathodes which cannot be decomposed. Herein, we report an H2O-wash method that could regenerate air cathodes and pretreat them for air-cathode characterization. We successfully regenerated two kinds of air cathodes for at least five rounds without capacity fading. The structural and chemical/electrochemical changes of air cathodes could be easily observed owing to the removal of discharge products. Volume expansion and functionalized carbon were observed after regeneration. Finally, the used air cathodes could be utilized for CO2 capture, thereby reducing the impact of CO2 emission. This study aims to show that Li–O2 batteries can not only serve as a device of high energy density but also as a solution to a greener future. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Three-year mortality in cryptococcal meningitis: Hyperglycemia predict unfavorable outcome
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Fu-Yu Lin, Hsiu-Yin Chiang, Pei-Shan Chen, Chin-Chi Kuo, and Sheng-Ta Tsai
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Male ,RNA viruses ,Physiology ,Cryptococcus ,Human immunodeficiency virus (HIV) ,Meningitis, Cryptococcal ,Pathology and Laboratory Medicine ,medicine.disease_cause ,Nervous System ,Medical Conditions ,Immunodeficiency Viruses ,Risk Factors ,Infectious Diseases of the Nervous System ,Medicine and Health Sciences ,Cerebrospinal Fluid ,Multidisciplinary ,biology ,Organic Compounds ,Mortality rate ,Monosaccharides ,Age Factors ,Eukaryota ,HIV diagnosis and management ,Middle Aged ,Prognosis ,Body Fluids ,Chemistry ,Cryptococcal Meningitis ,Infectious Diseases ,Neurology ,Medical Microbiology ,Viral Pathogens ,Physical Sciences ,Viruses ,Medicine ,Female ,Anatomy ,Pathogens ,Cryptococcal meningitis ,Research Article ,Adult ,medicine.medical_specialty ,Death Rates ,Science ,Carbohydrates ,Risk Assessment ,Microbiology ,Population Metrics ,HIV Seronegativity ,Internal medicine ,Diabetes mellitus ,Retroviruses ,medicine ,Humans ,Glasgow Coma Scale ,Microbial Pathogens ,Aged ,Retrospective Studies ,Population Biology ,business.industry ,Proportional hazards model ,Organic Chemistry ,Lentivirus ,Organisms ,Fungi ,Chemical Compounds ,Biology and Life Sciences ,HIV ,Retrospective cohort study ,biology.organism_classification ,medicine.disease ,Diagnostic medicine ,Glucose ,Hyperglycemia ,Metabolic Disorders ,Cryptococcus neoformans ,business ,Follow-Up Studies - Abstract
Existing evidence revealed grave prognosis for cryptococcal meningitis (CM), particularly its short-term mortality. However, its long-term survival and prognostic factors remained unknown. This study investigated 3-year mortality and analyzed its predictive factors in patients with CM. This retrospective cohort study with 83 cerebrospinal fluid culture-confirmed CM patients was conducted at China Medical University Hospital from 2003 to 2016. The 3-year mortality rate in patients with CM was 54% (45 deaths among 83 patients). Advanced age, human immunodeficiency virus (HIV) seronegative state, low Glasgow Coma Scale score on admission, decreased hemoglobin and hyperglycemia on diagnosis were associated with 3-year mortality. After multivariate adjustment in the Cox proportional hazard model, only severe hyperglycemia (serum glucose ≥200 mg/dL) on diagnosis could predict 3-year mortality.
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- 2021
16. Quantity-effect relationship of electroacupuncture for urge incontinence: A multicenter randomized controlled trial
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Feng, Qi-fan / 冯琦钒, Fu, Yu-lin / 傅御麟, Chen, Chao / 陈超, Xing, Man / 邢曼, Ha, Li-fu / 哈力甫, Zhao, Jian-hua / 赵建华, and Chen, Yue-lai / 陈跃来
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- 2012
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17. Therapeutic Potential of Tpl2 (Tumor Progression Locus 2) Inhibition on Diabetic Vasculopathy Through the Blockage of the Inflammasome Complex
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Po-Hsun Chen, Sheng-Mao Wu, Shing-Hwa Liu, Cheng Hsu Chen, Keng-Hung Lin, Maw-Rong Lee, Meei-Ling Sheu, Fu-Yu Lin, Chin-Chang Shen, Wen-Jane Lee, Wayne Huey-Herng Sheu, De-Wei Lai, Hsiang-Yu Yeh, and Jun-Sing Wang
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Male ,0301 basic medicine ,Databases, Factual ,Inflammasomes ,medicine.medical_treatment ,Angiogenesis Inhibitors ,Inflammation ,Retinal Pigment Epithelium ,Retinal Neovascularization ,Diabetes Mellitus, Experimental ,Neovascularization ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Pregnancy ,Proto-Oncogene Proteins ,medicine ,Animals ,Humans ,Prospective Studies ,Protein Kinase Inhibitors ,Cells, Cultured ,Aged ,Diabetic Retinopathy ,Retinal pigment epithelium ,business.industry ,Inflammasome ,Retinal ,Diabetic retinopathy ,Middle Aged ,MAP Kinase Kinase Kinases ,medicine.disease ,Mice, Inbred C57BL ,Cross-Sectional Studies ,Diabetes Mellitus, Type 1 ,030104 developmental biology ,medicine.anatomical_structure ,Cytokine ,Diabetes Mellitus, Type 2 ,chemistry ,030221 ophthalmology & optometry ,Cancer research ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Inflammasome complex ,Signal Transduction ,medicine.drug - Abstract
Objective: Diabetic retinopathy, one of retinal vasculopathy, is characterized by retinal inflammation, vascular leakage, blood-retinal barrier breakdown, and neovascularization. However, the molecular mechanisms that contribute to diabetic retinopathy progression remain unclear. Approach and Results: Tpl2 (tumor progression locus 2) is a protein kinase implicated in inflammation and pathological vascular angiogenesis. N Ɛ -carboxymethyllysine (CML) and inflammatory cytokines levels in human sera and in several diabetic murine models were detected by ELISA, whereas liquid chromatography–tandem mass spectrometry analysis was used for whole eye tissues. The CML and p-Tpl2 expressions on the human retinal pigment epithelium (RPE) cells were determined by immunofluorescence. Intravitreal injection of pharmacological inhibitor or NA (neutralizing antibody) was used in a diabetic rat model. Retinal leukostasis, optical coherence tomography, and H&E staining were used to observe pathological features. Sera of diabetic retinopathy patients had significantly increased CML levels that positively correlated with diabetic retinopathy severity and foveal thickness. CML and p-Tpl2 expressions also significantly increased in the RPE of both T1DM and T2DM diabetes animal models. Mechanistic studies on RPE revealed that CML-induced Tpl2 activation and NADPH oxidase, and inflammasome complex activation were all effectively attenuated by Tpl2 inhibition. Tpl2 inhibition by NA also effectively reduced inflammatory/angiogenic factors, retinal leukostasis in streptozotocin-induced diabetic rats, and RPE secretion of inflammatory cytokines. The attenuated release of angiogenic factors led to inhibited vascular abnormalities in the diabetic animal model. Conclusions: The inhibition of Tpl2 can block the inflammasome signaling pathway in RPE and has potential clinical and therapeutic implications in diabetes-associated retinal microvascular dysfunction.
- Published
- 2020
18. Dissemination of the tet(X)-Variant Genes from Layer Farms to Manure-Receiving Soil and Corresponding Lettuce
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He, Tao, primary, Wei, Rui-Cheng, additional, Zhang, Lili, additional, Gong, Lan, additional, Zhu, Lei, additional, Gu, Jili, additional, Fu, Yu-Lin, additional, Wang, Yang, additional, Liu, De-Jun, additional, and Wang, Ran, additional
- Published
- 2021
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19. Designing by frontline tobacco-prevention practitioners: How can Design Thinking workshop affect the development of public health strategies?
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Fu-Yu Lin, Min-yuan Ma, and Eric Chen-F Hsieh
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medicine.medical_specialty ,business.industry ,Public health ,medicine ,Tobacco prevention ,Design thinking ,Public relations ,business ,Affect (psychology) ,Psychology ,Strategy development - Published
- 2020
20. Idarucizumab-facilitated intravenous thrombolysis in acute stroke with dabigatran: Two cases with hemorrhagic transformation
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Fu-Yu Lin, Yi Te Tsai, Pao-Sheng Yen, Yu-Jen Hsiao, Ching-Hua Lu, Chen-Wen Fang, and Li-Kai Tsai
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Idarucizumab ,Thrombolysis ,030204 cardiovascular system & hematology ,Dabigatran ,03 medical and health sciences ,0302 clinical medicine ,Neurology ,Internal medicine ,Ischemic stroke ,medicine ,Cardiology ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Acute stroke ,medicine.drug - Published
- 2018
21. Increased risk of overactive bladder in patients with idiopathic Parkinson’s disease: Insight from a nationwide population-based cohort study
- Author
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Yi-Chien Yang, Lukas Jyuhn-Hsiarn Lee, Fu-Yu Lin, and Cheng-Li Lin
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Male ,Urinary urgency ,030232 urology & nephrology ,lcsh:Medicine ,Comorbidity ,Kaplan-Meier Estimate ,urologic and male genital diseases ,Cohort Studies ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Medicine and Health Sciences ,Cumulative incidence ,Longitudinal Studies ,lcsh:Science ,Aged, 80 and over ,Multidisciplinary ,Movement Disorders ,Incidence ,Hazard ratio ,Age Factors ,Neurodegenerative Diseases ,Parkinson Disease ,Middle Aged ,Overactive bladder ,Neurology ,Research Design ,Cohort ,Female ,medicine.symptom ,Anatomy ,Cohort study ,Research Article ,medicine.medical_specialty ,Endocrine Disorders ,Urology ,Bladder ,Cerebrovascular Diseases ,Taiwan ,Research and Analysis Methods ,03 medical and health sciences ,Exocrine Glands ,Lower urinary tract symptoms ,Internal medicine ,medicine ,Diabetes Mellitus ,Humans ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Incontinence ,business.industry ,Urinary Bladder, Overactive ,lcsh:R ,Biology and Life Sciences ,Retrospective cohort study ,Renal System ,medicine.disease ,bacterial infections and mycoses ,Metabolic Disorders ,lcsh:Q ,Prostate Gland ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Background Idiopathic Parkinson’s disease (IPD) is a progressive neurodegenerative disorder characterized by typical motor impairment. However, lower urinary tract symptoms, including urinary urgency or frequency, which are non-motor phenomena, occur frequently among patients with IPD. In this study, we assess the risk of overactive bladder (OAB) in patients with IPD. Methods The National Health Insurance Research Database of Taiwan was used to identify patients with IPD (IPD cohort) and four-fold controls (non-IPD cohort) from 2000 to 2010. The non-IPD cohort was matched according to age, sex, and baseline comorbidities, including benign prostate hyperplasia, stress incontinence, diabetes, and cerebrovascular diseases. The occurrence of OAB was monitored until the end of 2011. Hazard ratios of OAB were estimated using Cox proportional hazards regression models. Results In total, 4,571 and 18,255 patients were included in IPD and non-IPD cohorts, respectively. Results showed a significantly higher overall incidence rate of OAB in the IPD cohort compared with the non-IPD cohort (14.5 vs. 6.37 per 10,000 person-years), with a 2.3-fold increased risk of OAB (95% confidence interval [CI] = 1.51–3.51) after controlling for benign prostate hyperplasia and stress incontinence. The mean follow-up period for the IPD cohort was 5.0 years. This cohort study showed that the cumulative incidence of OAB was 0.65% at the fifth year and 1.54% at the tenth year after IPD diagnosis; this risk was highest in the age group 65–74 years. Conclusion This study reveals that IPD is independently associated with an increased risk of OAB in patients with IPD. The probability of OAB was 1.54% over a 10-year period after IPD diagnosis; the risk of OAB is considered to be age-dependent and most substantial in patients aged 65–74 years.
- Published
- 2018
22. The effect of sensation of transmission along meridian acupuncture for chronic nonbacterial prostatitis
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MING, Shu-ren, primary, FU, Yu-lin, additional, HOU, Wen-guang, additional, and CHEN, Yue-lai, additional
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- 2019
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23. Coincidence or complication? A systematic review of trigger digit after carpal tunnel release
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Hsu-Tang Cheng, Fu-Yu Lin, and Chao-I Wu
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Adult ,Male ,medicine.medical_specialty ,Risk Assessment ,Sensitivity and Specificity ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Carpal tunnel release ,Trigger Digits ,Prevalence ,Medicine ,Humans ,In patient ,Carpal tunnel syndrome ,030222 orthopedics ,business.industry ,Incidence (epidemiology) ,Middle Aged ,medicine.disease ,Decompression, Surgical ,Trigger digit ,Carpal Tunnel Syndrome ,Surgery ,Trigger Finger Disorder ,Female ,Trigger finger ,business ,Complication ,030217 neurology & neurosurgery - Abstract
Carpal tunnel syndrome (CTS) and trigger digits are among the most common nontraumatic hand disorders treated by plastic surgeons. The onset of trigger digits after carpal tunnel release (CTR) has been inconsistently reported. This systematic review assessed the prevalence of trigger digits development in patients after CTR surgery.We searched the MEDLINE, EMBASE and SCOPUS databases for papers published between January 1966 and August 2016. Eligible studies contained quantitative data on the incidence of trigger digits after CTR. The primary outcome measure was the onset of trigger digits after CTR. The secondary outcome measure was the prevalence of digital involvement in patients who developed trigger digits after CTR.A total of 5654 CTR surgeries were performed in the included nine studies, and 483 patients (8.5%) developed trigger digits after CTR. The reported incidence of trigger digits after CTR ranged from 5.2% to 31.7%. The time to development of trigger digits was approximately 6 months postoperatively. In the eight observational studies and in the randomized controlled trial, the thumb and ring finger were reported as the most commonly involved trigger digits, respectively.The incidence of trigger digits after CTR surgery is not negligible. Thumbs and ring fingers are the most commonly involved digits. This topic should therefore be suitably addressed during preoperative consultations.
- Published
- 2017
24. Issues and solutions of conditional gene targeting
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Fu-Yu Lin and Xiao Yang
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Genetics ,Experimental control ,Expression pattern ,Transgene ,Gene targeting ,Cre recombinase ,General Medicine ,Biology ,Phenotype ,Gene ,Recombination - Abstract
Conditional gene targeting, based on the site-specific recombination system such as Cre-loxP, plays a vital role in the study of gene functions and the generation of disease mouse models. It was always under consideration that there were problems in the Cre-loxP recombination system, such as illegal expression pattern of Cre transgene, variation of Cre recombination efficiency and toxicity of Cre recombinase, as well as the potential influences of genetic background, breeding strategy, experimental control and gene compensation. Oversights of these issues may have a profound influence on the accuracy of gene functional dissection and conditional gene targeting mice phenotypic interpretation. Accordingly, solutions should be adopted including delicate regulative control of temporal-spatial specific Cre expression, detailed detection of Cre recombination efficiency, reduction of Cre toxicity, simplification of mouse genetic background, optimization of breeding, setting up of proper control and combined conditional gene targeting.
- Published
- 2011
25. Mandibular Fracture Patterns at a Medical Center in Central Taiwan
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Hsu-Tang Cheng, Fu-Yu Lin, and Chao-I Wu
- Subjects
medicine.medical_specialty ,business.industry ,Symphysis ,Mandibular fracture ,Incidence (epidemiology) ,Medical record ,Dentistry ,Retrospective cohort study ,030206 dentistry ,General Medicine ,medicine.disease ,Condyle ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,stomatognathic system ,030220 oncology & carcinogenesis ,Epidemiology ,medicine ,Young adult ,business - Abstract
Mandibular fractures constitute a major portion of maxillofacial trauma and may lead to considerable functional and aesthetic sequelae if treatment is inadequate or delayed. An epidemiology study on mandibular fractures may guide the preventive efforts of the Taiwan public health care system. Therefore, a retrospective review was conducted at a medical center in central Taiwan to evaluate the current mandibular fracture epidemiology.The medical records and digitized radiographs of 198 patients who received treatment for mandibular fractures during a 3-year period (from October 2010 to September 2013) at a medical center in central Taiwan were reviewed to obtain demographic and injury data.The average age was 29.4 years (3-82 years). Patients aged 21 to 30 years sustained the most mandibular fractures (62 patients, 31.3%). The overall sex distribution (male to female) ratio was 1.8. Motor-vehicle accidents (MVAs) were the most common mechanism of injury (162 patients, 82%), and scooter and motorcycle riders wearing partial-coverage helmets constituted the majority of patients. A chart review identified 198 patients with 335 mandibular fractures; 113 patients (57.1%) had multiple mandibular fractures. The most common fracture sites were the symphysis and parasymphysis regions (38.9%), followed by the condyle (26.0%), angle (14.3%), body (14.3%), and ramus (6.6%).MVAs are the major cause of mandibular fractures in central Taiwan, and patients aged
- Published
- 2017
26. Fibrodysplasia ossificans progressiva: initial presentation with a preosseous lesion of the scalp and its MRI appearance
- Author
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Chien-Hung Lin, Ginger Shu, Clement K. H. Chen, and Fu-Yu Lin
- Subjects
Thorax ,medicine.medical_specialty ,030218 nuclear medicine & medical imaging ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Biopsy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Scalp ,medicine.diagnostic_test ,business.industry ,Ossification, Heterotopic ,Infant ,Magnetic resonance imaging ,Myositis ossificans ,medicine.disease ,Magnetic Resonance Imaging ,Radiography ,medicine.anatomical_structure ,Myositis Ossificans ,Fibrodysplasia ossificans progressiva ,Female ,Radiology ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Thoracic wall - Abstract
This case subject is a 1-year-old girl presenting with recurrent diffuse soft-tissue swelling of the scalp and periorbital region. Her family denied any known history of trauma. There was no obvious discoloration or local heat at the lesion. Magnetic resonance imaging (MRI) revealed diffuse soft tissue swelling of the scalp manifesting as high signal intensity on T2-weighted images and low signal intensity on T1-weighted images with diffuse enhancement after gadolinium-contrast administration. Biopsy yielded inconclusive pathological results. Fibrodysplasia ossificans progressiva (FOP) was not suspected until malformation of the patient's toes was noticed. The scalp lesion underwent spontaneous regression, and subsequent radiographs of the chest and cervical spine revealed heterotopic ossifications of the neck and thorax. Early diagnosis of FOP is vital because trauma, unnecessary biopsy and intramuscular injection are known to cause acceleration of heterotopic ossifications. Previous studies reported diffuse soft tissue swelling at the posterior neck, thoracic wall or paraspinal region as preosseous lesions of FOP (Shiva Kumar et al. Neurology. 2010;74(6):e20, Merchant et al. Pediatr Radiol. 2006;36(10):1108-11, Hagiwara et al. AJR Am J Roentgenol. 2003;181(4):1145-7). To our knowledge, diffuse soft tissue swelling of the scalp as a preosseous lesion of FOP and associated MRI findings have not yet been reported. We believe that awareness of preosseous lesions presenting as diffuse soft tissue swelling, in addition to shortening and valgus deformity of the great toes, is an important diagnostic clue for establishing FOP.
- Published
- 2015
27. Derivation and validation of a discharge disposition predicting model after acute stroke
- Author
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Hung-Pin Tseng, Feng-Jenq Lin, Pi-Tzu Chen, Chih-Hsin Mou, Siu-Pak Lee, Chun-Yuan Chang, An-Chih Chen, Chung-Hsiang Liu, Chung-Hsin Yeh, Song-Yen Tsai, Yu-Jen Hsiao, Ching-Huang Lin, Shih-Pin Hsu, Shih-Chieh Yu, Chung-Y. Hsu, Fung-Chang Sung, Jiann-Shing Jeng, Shin-Joe Yeh, Li-Kai Tsai, Hou-Chang Chiu, Li-Ming Lien, Wei-Hung Chen, Chyi-Huey Bai, Tzu-Hsuan Huang, Chi-Ieong Lau, Ya-Ying Wu, Rey-Yue Yuan, Chaur-Jong Hu, Jau-Jiuan Sheu, Jia-Ming Yu, Chun-Sum Ho, Wen-Ting Chung, Jia-Ying Sung, Chin-I Chen, Hsing-Yu Weng, Yu-Hsuan Han, Chun-Ping Huang, Huey-Juan Lin, Der-Shin Ke, Chia-Yu Chang, Poh-Shiow Yeh, Kao-Chang Lin, Tain-Junn Cheng, Chih-Ho Chou, Chun-Ming Yang, Yuk-Keung Lo, Yu-Te Lin, Ching-Hwung Lin, Jiann-Chyun Lin, Yaw-Don Hsu, Jong-Chyou Denq, Giia-Sheun Peng, Jiunn-Tay Lee, Chang-Hung Hsu, Chun-Chieh Lin, Che-Hung Yen, Chun-An Cheng, Yueh-Feng Sung, Yuan-Liang Chen, Ming-Tung Lien, Chung-Hsing Chou, Chia-Chen Liu, Fu-Chi Yang, Yi-Chung Wu, An-Chen Tso, Yu-Hua Lai, Chun-I Chiang, Chia-Kuang Tsai, Meng-Ta Liu, Ying-Che Lin, Yu-Chuan Hsu, Chon-Haw Tsai, Wei-Shih Huang, Chung-Ta Lu, Tzung-Chang Tsai, Chun-Hung Tseng, Kang-Hsu Lin, Woei-Cherng Shyn, Yu-Wan Yang, Yen-Liang Liu, Der-Yang Cho, Chun-Chung Chen, Ming-Hui Sun, Li-Ying Ke, Ming-Liang Lai, Chih-Hung Chen, Jiunn-Rong Chen, Tsuey-Ru Chiang, Mei-Ching Lee, Shinn-Kuang Lin, Yuan-Fu Tseng, Jing-Er Lee, Cheng-Lun Hsiao, Jen-Feng Liang, Chiu-Mei Chen, Chao-Hsin Wu, Yu-Wei Chen, Kuo-Ying Lee, Yun-Yu Lin, Chen-Hua Li, Eric E. Smith, Hui-Fen Tsai, Chuan-Fa Hsieh, Chih-Dong Yang, Shiumn-Jen Liaw, How-Chin Liao, Han-Hwa Hu, Wen-Jang Wong, Yun-On Luk, Chang-Ming Chern, Li-Chi Hsu, Chih-Ping Chung, Mu-Chien Sun, Shey-Lin Wu, Chin-Hsiung Liu, Chun-Liang Lin, Hung-Chih Lin, Ta-Chang Lai, Jiu-Haw Yin, Chung-Jen Wang, Kai-Chen Wang, Li-Mei Chen, Lung Chan, Yu Sun, Chieh-Cheng Huang, Chang-Hsiu Liu, Cheng-Huai Lin, Chien-Jung Lu, Shoou-Jeng Yeh, Ling-Li Wu, Liang-Po Hsieh, Yong-Hui Lee, Chung-Wen Chen, Po-Lin Chen, Yu-Shan Lee, Shu-Yi Chen, Han-Jung Chen, Cheng-Sen Chang, Hung-Chang Kuo, Shu-Lung Wu, Huan-Wen Tsui, Jung-Chi Tsou, Feng-Hsiung Chou, Pei-Jung Lin, Chin-Sung Tung, Kan Lu, Po-Chou Liliang, Yu-Duan Tsai, Cheng-Loong Liang, Kuo-Wei Wang, Hao-Kuang Wang, Te-Yuan Chen, Yue-Loong Hsin, Chih-Yuan Lin, Bak-Sau Yip, Pei-Chun Tsai, Ping-Chen Chou, Tsam-Ming Kuo, Yi-Chen Lee, Yi-Pin Chiu, Kun-Chang Tsai, Ruey-Tay Lin, Chun-Hung Chen, Gim-Thean Khor, A-Ching Chao, Hsiu-Fen Lin, I-Sheng Lin, Sui-Hing Yan, Yi-Chun Lin, Pei-Yun Chen, Sheng-Huang Hsiao, Helen L. Po, Ya-Ju Lin, Hao-Chieh Tu, Sung-Chun Tang, Fu-Yu Lin, Ping-Kun Chen, Pai-Yi Chiu, Ping-Keung Yip, Vin-Chi Wang, Kaw-Chen Wang, Chung-Fen Tsai, Chao-Ching Chen, Chih-Hao Chen, Yi-Chien Liu, Chou-Hsiung Pan, Shin-Yi Jih, Po-Chi Chan, Min-Hsien Hsu, Hai-Ming Shoung, Yi-Chen Lo, Fu-Hwa Wang, Cheng-Yu Wei, Jun-Yu Lee, Ryh-Huei Lin, Ching-Hua Chu, and Ming-Chin Hsu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Risk Assessment ,Young Adult ,Risk Factors ,Diabetes mellitus ,medicine ,Humans ,Derivation ,Stroke ,Aged ,Aged, 80 and over ,Framingham Risk Score ,Receiver operating characteristic ,business.industry ,Rehabilitation ,Odds ratio ,Disposition ,Middle Aged ,Models, Theoretical ,medicine.disease ,Confidence interval ,Patient Discharge ,Nursing Homes ,Hospitalization ,Emergency medicine ,Physical therapy ,Surgery ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Discharge disposition planning is vital for poststroke patients. We investigated clinical factors associated with discharging patients to nursing homes, using the Taiwan Stroke Registry data collected from 39 major hospitals. Methods We randomly assigned 21,575 stroke inpatients registered from 2006 to 2008 into derivation and validation groups at a 3-to-1 ratio. We used the derivation group to develop a prediction model by measuring cumulative risk scores associated with potential predictors: age, sex, hypertension, diabetes mellitus, heart diseases, stroke history, snoring, main caregivers, stroke types, and National Institutes of Health Stroke Scale (NIHSS). Probability of nursing home care and odds ratio (OR) of nursing home care relative to home care by cumulative risk scores were measured for the prediction. The area under the receiver operating characteristic curve (AUROC) was used to assess the model discrimination against the validation group. Results Except for hypertension, all remaining potential predictors were significant independent predictors associated with stroke patient disposition to nursing home care after discharge from hospitals. The risk sharply increased with age and NIHSS. Patients with a cumulative risk score of 15 or more had an OR of 86.4 for the nursing home disposition. The AUROC plots showed similar areas under curves for the derivation group (.86, 95% confidence interval [CI], .85-.87) and for the validation group (.84, 95% CI, .83-.86). Conclusions The cumulative risk score is an easy-to-estimate tool for preparing stroke patients and their family for disposition on discharge.
- Published
- 2014
28. Abstract
- Author
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Hsu-Tang Cheng, Oscar J. Manrique, Cheng-Li Lin, Fu-Yu Lin, and Yung-Chang Hsu
- Subjects
medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Carpal tunnel release ,Trigger Digits ,Medicine ,Surgery ,business - Published
- 2016
29. Incidence of trigger digits following carpal tunnel release
- Author
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Oscar J. Manrique, Fu-Yu Lin, Hsu-Tang Cheng, and Cheng-Li Lin
- Subjects
030222 orthopedics ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Proportional hazards model ,Incidence (epidemiology) ,Hazard ratio ,Population ,Retrospective cohort study ,General Medicine ,medicine.disease ,Confidence interval ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Cohort ,Medicine ,business ,Carpal tunnel syndrome ,education ,030217 neurology & neurosurgery - Abstract
The onset of trigger digits after carpal tunnel release (CTR) have been reported inconsistently across different studies. The aim of this study is to assess the incidence of trigger digits after CTR using nationwide population cohort data. We conducted a retrospective cohort study using the Longitudinal Health Insurance Database 2000 (LHID2000) from the National Health Insurance Database (NHIRD) in Taiwan. The LHID2000 contained 1 million beneficiaries randomly selected from the year 2000 Registry for Beneficiaries in NHIRD. We identified 2605 carpal tunnel syndrome (CTS) patients received CTR from 2000 to 2010 (CTR cohort, n = 2605). For each CTR patient, 4 CTS patients without CTR were randomly selected in the control cohort from the general population frequency matched by age, sex, and diagnosed year (non-CTR cohort, n = 10,420). Both cohorts were followed up until the end of 2011 to investigate the occurrence of trigger digits. Adjusted hazard ratios (aHRs) with 95% confidence interval (CI) of trigger digits were estimated using the Cox proportional hazards model after controlling for age, sex, and comorbidities. The CTR cohort had a mean follow-up period of 5.58 ± 3.18 years and the non-CTR cohort had a mean follow-up period of 5.90 ± 3.10 years. The overall risk of trigger digits was 3.63-fold greater in the CTR cohort than in the non-CTR cohort (incidence rate: 12.6 vs 3.38/1000 person-years, aHR: 3.63, 95% CI, 2.97–4.44). The incidence of postoperative trigger digits was highest in the 1st 6 months (incidence rate: 27.9/1000 person-years, aHR: 9.65, 95% CI, 5.27–17.7) and then significantly decreased over time. CTR was significantly associated with the subsequent development of trigger digits, especially in the postoperative 6 months.
- Published
- 2017
30. Reversible Splenial Lesion of the Corpus Callosum in Migraine With Aura
- Author
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Chung-Yi Yang and Fu-Yu Lin
- Subjects
Adult ,Male ,Aura ,business.industry ,Migraine with Aura ,Brain Edema ,General Medicine ,Corpus callosum ,medicine.disease ,Magnetic Resonance Imaging ,Migraine with aura ,Corpus Callosum ,Lesion ,Migraine ,Neuroimaging ,Cortical spreading depression ,Humans ,Medicine ,Neurology (clinical) ,medicine.symptom ,business ,Splenial ,Neuroscience - Abstract
Migraine with aura has long been believed to be related to the phenomenon of cortical spreading depression. Clinically, there are no consistent neuroimaging findings corresponding to an attack of migraine with aura.We describe a patient suffering from migraine with aura associated with a transient abnormality in the midline of the splenium of the corpus callosum, showed by a magnetic resonance imaging. Features of edema and restricted diffusion indicated that there was cytotoxic edema.There have been reports of various etiologies associated with a temporary focal lesion in the splenium of the corpus callosum manifested as obviously restricted diffusion. These findings may be the consequence of a high vulnerability of the splenium of the corpus callosum to cytotoxic damage. Migraine with aura was considered to be the cause of the reversible focal injury of the splenium in this case. This association has not been reported earlier.
- Published
- 2011
31. Diagnostic efficacy of color Doppler ultrasonography in preoperative assessment of anterolateral thigh flap cutaneous perforators: an evidence-based review
- Author
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Hsu-Tang Cheng, Sophia Chia-Ning Chang, and Fu-Yu Lin
- Subjects
medicine.medical_specialty ,Evidence-Based Medicine ,business.industry ,MEDLINE ,Reproducibility of Results ,Evidence-based medicine ,Skin Transplantation ,Anterolateral thigh ,Evidence based review ,Skin transplantation ,Preoperative care ,Surgical Flaps ,Surgery ,Thigh ,Preoperative Care ,Color doppler ultrasonography ,Medicine ,Humans ,Radiology ,Ultrasonography, Doppler, Color ,business ,Skin - Published
- 2013
32. Mandibular Fracture Patterns at a Medical Center in Central Taiwan: A 3-Year Epidemiological Review.
- Author
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Fu-Yu Lin, Chao-I Wu, Hsu-Tang Cheng, Lin, Fu-Yu, Wu, Chao-I, and Cheng, Hsu-Tang
- Published
- 2017
- Full Text
- View/download PDF
33. Diagnostic efficacy of preoperative 64-section multidetector computed tomographic angiography in identifying the cutaneous perforators in the anterolateral thigh flap: an evidence-based review
- Author
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Fu-Yu Lin, Sophia Chia-Ning Chang, and Hsu-Tang Cheng
- Subjects
medicine.medical_specialty ,business.industry ,Angiography ,Anterolateral thigh ,Evidence based review ,Surgical Flaps ,Computed tomographic angiography ,Section (archaeology) ,Multidetector Computed Tomography ,Preoperative Period ,Medicine ,Humans ,Surgery ,Radiology ,business - Published
- 2012
34. Evaluation of diagnostic accuracy using preoperative handheld Doppler in identifying the cutaneous perforators in the anterolateral thigh flap: a systematic review
- Author
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Hsu-Tang Cheng, Fu-Yu Lin, and Sophia Chia-Ning Chang
- Subjects
medicine.medical_specialty ,business.industry ,MEDLINE ,Diagnostic accuracy ,Ultrasonography, Doppler ,Anterolateral thigh ,Sensitivity and Specificity ,Surgical Flaps ,Surgery ,symbols.namesake ,Thigh ,Predictive Value of Tests ,Predictive value of tests ,Preoperative Period ,symbols ,Medicine ,Humans ,Radiology ,Ultrasonography ,business ,Doppler effect - Published
- 2012
35. External or internal jugular vein? Recipient vein selection in head and neck free tissue transfer: an evidence-based systematic analysis
- Author
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Fu-Yu Lin, Sophia Chia-Ning Chang, and Hsu-Tang Cheng
- Subjects
Venous Thrombosis ,medicine.medical_specialty ,Evidence-Based Medicine ,business.industry ,Anastomosis, Surgical ,Anatomy ,Plastic Surgery Procedures ,Free Tissue Flaps ,Tissue transfer ,medicine.anatomical_structure ,Medicine ,Humans ,Surgery ,Radiology ,Jugular Veins ,business ,Head and neck ,Vein ,Internal jugular vein ,Head ,Selection (genetic algorithm) ,Neck - Published
- 2012
36. Free-flap salvage by thrombolytic agents? An evidence-based systemic analysis
- Author
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Fu-Yu Lin, Sophia Chia-Ning Chang, and Hsu-Tang Cheng
- Subjects
medicine.medical_specialty ,Evidence-based practice ,Systemic analysis ,Evidence-Based Medicine ,business.industry ,medicine.medical_treatment ,Anastomosis, Surgical ,Thrombosis ,Evidence-based medicine ,Free flap ,Anastomosis ,Microsurgery ,medicine.disease ,Free Tissue Flaps ,Surgery ,Fibrinolytic Agents ,medicine ,Thrombolytic Agent ,Humans ,business - Abstract
INTRODUCTION: Despite the advances in microsurgery and the experience gained in clinical practice, failures caused by thrombosis at the site of microanastomosis remains a challenge to plastic surgeons. The failure rate of approximately 5% of all free-flap surgeries clinically suggested that there may be a place for pharmacological intervention at the time of threatened flap failure. But there was no consensus on the role of thrombolytic agents in free-flap salvage.
- Published
- 2012
37. Images in emergency medicine. Man with sudden onset of bilateral flank pain. Polyarteritis nodosa
- Author
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Fu-Yu, Lin, I-Ha, Lao, Yen-Jen, Wang, and Wen-Sheng, Tzeng
- Subjects
Male ,Humans ,Flank Pain ,Emergency Service, Hospital ,Tomography, X-Ray Computed ,Aged ,Polyarteritis Nodosa ,Ultrasonography - Published
- 2012
38. Dyke-Davidoff-Masson syndrome with crossed cerebellar atrophy
- Author
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Fu-Yu, Lin and Lung-Shiang, Lai
- Subjects
Facial Asymmetry ,Seizures ,Cerebellum ,Humans ,Female ,Hemiplegia ,Syndrome ,Atrophy ,Middle Aged - Published
- 2010
39. Aesthetic correction of adult unoperated torticollis
- Author
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Fu-Yu Lin, Hsu-Tang Cheng, Chao-I Wu, and Sophia Chia-Ning Chang
- Subjects
Male ,medicine.medical_specialty ,Weakness ,Esthetics ,business.industry ,General Medicine ,medicine.disease ,Fibrosis ,Surgery ,Plastic surgery clinic ,Young Adult ,Otorhinolaryngology ,medicine ,Left sternocleidomastoid muscle ,Tightness sensation ,Humans ,Muscle Strength ,medicine.symptom ,Range of Motion, Articular ,business ,Torticollis - Abstract
A 24-year-old man presented to the plastic surgery clinic complaining of left-side neck persistent tightness sensation for years. He had a palpable broad fibrotic band over his left sternocleidomastoid muscle. In addition, it revealed mild but definite weakness by manual muscle test. Congenital muscular torticollis in adult is a treatable disease and usually mimics neurogenic cervical torsion dystonia. After the diagnosis was confirmed, he underwent resection of the left sternocleidomastoid muscle and underlying deep cervical fascia and relieving of extensive fibrosis. Postoperatively, his uncomfortable sensation improved, and there was no limitation of neck range of motion. After an autologous fat graft implantation to his left-side neck, there was a satisfied left-side-neck condition and aesthetic outcome.
- Published
- 2010
40. Cerebral infarct due to concomitant anterior cerebral artery dissection and dissecting aneurysm
- Author
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Fu-Yu, Lin and Bang-Bin, Chen
- Subjects
Male ,Aortic Dissection ,Anterior Cerebral Artery ,Humans ,Intracranial Aneurysm ,Cerebral Arterial Diseases ,Cerebral Infarction ,Middle Aged - Published
- 2010
41. Virtual Impedance Analyzer Design and Implementation
- Author
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Li-ling Chao, Fu-yu Lin, Kai-chao Yao, and Chin-Wen Liao
- Subjects
Spectrum analyzer ,Software ,Data acquisition ,Virtual instrumentation ,business.industry ,Computer science ,Reactance ,Process (computing) ,business ,Electrical impedance ,Computer hardware ,Electronic circuit - Abstract
In this research, the structure and design of virtual impedance analyzers are studied. The construction process is also described and introduced. This programmable virtual impedance analyzer is achieved by software part, Labview, hardware part, DAQ card and some external circuits. The measurement functions include: (1) impedance [Z] display that has magnitude, phase, impedance and reactance, (2) display settings that has visible section and scale, (3) measurement frequency control, (4) run button, and (5) display window. In the illustrations, demonstrate the design of front panels and also proceed the measurement test of designed virtual impedance analyzer to show the capabilities.
- Published
- 2007
42. Incidence of trigger digits following carpal tunnel release: A nationwide, population-based retrospective cohort study.
- Author
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Fu-Yu Lin, Manrique, Oscar J., Cheng-Li Lin, Hsu-Tang Cheng, Lin, Fu-Yu, Lin, Cheng-Li, and Cheng, Hsu-Tang
- Published
- 2017
- Full Text
- View/download PDF
43. [Study on a human tissue-type plasminogen activator mutant cDNA knocked-in the beta-casein gene site of murine ES cells]
- Author
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Fu-Yu, Lin, Xiao, Yang, Ji-Xian, Deng, Hong-Xing, Chen, and Pei-Tango, Huang
- Subjects
Mice ,Stem Cells ,Tissue Plasminogen Activator ,Gene Targeting ,Animals ,Caseins ,Humans ,Embryo, Mammalian - Abstract
A murine beta-casein gene targeting vector was constructed using the cloned genomic sequence. The short arm was 2.7 kb including mouse beta-casein gene 5' flanking sequence, exon1, intron1 and partial exon2. The long arm is a 3.4 kb fragment including partial intron2, exon3 approximately 7, intron3 approximately 6 and partial intron7. The human t-PA mutant cDNA was subcloned in the exon2 and fused with the mice beta-casein signal peptide sequence. The positive selective marker neo was placed in the middle of intron2. A tk negative selective marker was just outside the short arm. TC-1 ES cells were cultured and amplified on G418 resistant feeder layer. The linearized targeting construct DNAs of 45 microg were introduced into 2 x 10(7) ES cells by electroporation. Totally 192 ES clones were picked up after cultured in G418 and Gancyclovir for 7 days. The colonies were amplified and subjected to genomic DNA preparation. The genomic DNAs were digested with EcoR I and used for Southern blot analysis. A probe inside the 5' homologous arm was used for hybridization. A 9.8 kb band was found in wild type, but the band was shift down from 9.8 kb to 6.6 kb in the beta-casein gene targeted allele because a new EcoR I site was introduced into the exon2 along with the human t-PA mutant gene. There were 9.8 kb and 6.6 kb bands in targeted ES cells. One clone of targeted ES cells with correct homologous recombination events was obtained among 78 analyzed clones. It lays foundation for gene targeted mice making.
- Published
- 2004
44. A human t-PA mutant cDNA cassette knocked in the murine fgfr-4 locus targeting for mammary gland expression
- Author
-
Fu-Yu, Lin, Hong-Xing, Chen, Xuan, Cheng, Yang, Xiao, Ji-Xian, Deng, and Pei-Tang, Huang
- Subjects
Male ,DNA, Complementary ,Base Sequence ,Genotype ,Receptors, Fibroblast Growth Factor ,Mice, Inbred C57BL ,Mice ,Mutagenesis, Insertional ,Milk ,Animals ,Humans ,Female ,Receptor, Fibroblast Growth Factor, Type 4 ,Mammary Glands, Human ,DNA Primers - Abstract
The expression of foreign gene in transgenic animals produced by pronuclear microinjection is often confounded by the position effects caused by not only the nature of chromosomal integration site but also the number and arrangement of multiple transgene copies. Gene targeting provides a new way to overcome these inhibitions by introducing single-copy transgene into a chosen site. The choice of a good chromosomal site will favor transgene expression in a predictable fashion. In this study, we tested a new site (fgfr-4) for foreign gene integration and expression. A t-PA mutant (t-PAm) expression cassette under bovine alphas1-casein regulatory sequences was efficiently knocked-in fgfr-4 site through homologous recombination. The t-PAm was expressed in the milk of all targeted mice. Our experiment indicates that the fgfr-4 may be a candidate site for knocking foreign gene to make transgenic animals.
- Published
- 2004
45. [Murine beta-casein gene sequences direct a human tissue plasminogen activator variant expressed in the milk of transgenic mice]
- Author
-
Fu-Yu, Lin, Xuan, Cheng, Hong-Xing, Chen, Xiao-Hong, Tan, Jing, Cheng, Xiao, Yang, Ji-Xian, Deng, and Pei-Tang, Huang
- Subjects
Male ,Mice ,Milk ,Recombinant Fusion Proteins ,Tissue Plasminogen Activator ,Animals ,Caseins ,Humans ,Female ,Mice, Transgenic - Abstract
To investigate the ability of our cloned murine beta-casein locus to direct the exogenous gene expression in the milk of transgenic mice, the human t-PA variant mammary gland expression vector under the control of murine beta-casein gene regulatory elements was constructed, in which the human t-PA variant signal-pro peptide sequence was replaced with murine beta-casein signal peptide sequence and the human t-PA variant mature peptide cDNA was inserted into the second exon of beta-casein gene. The fusion gene was microinjected in the fertilized mice eggs. A total of 285 embryos were microinjected and transferred into 13 surrogate mother mice. Twelve positive transgenic mice were identified through PCR and Southern blot analysis among 42 new born mice. Human t-PA variant was expressed in the milk of 7 transgenic mice, the highest expression level attained to 3.6593 micrograms/ml. The results demonstrated that the murine beta-casein gene regulatory elements can direct the human t-PA variant gene successfully express in the milk of transgenic mice. It lays great foundation for the research on the beta-casein knock-in mice mammary gland bioreactor model construction.
- Published
- 2003
46. Evidence-Based Analysis of Vein Graft Interposition in Head and Neck Free Flap Reconstruction
- Author
-
Hsu-Tang Cheng, Sophia Chia-Ning Chang, and Fu-Yu Lin
- Subjects
Microsurgery ,medicine.medical_specialty ,business.industry ,Vein graft ,Plastic Surgery Procedures ,Free Tissue Flaps ,Veins ,Surgery ,Text mining ,medicine ,Humans ,Free flap reconstruction ,Head and neck ,business ,Head ,Neck - Published
- 2012
47. Effect of Relative Height of Planting Denture on Interdental Food Impaction: A Numerical Study
- Author
-
Qiao, Ai Ke, primary, Zhang, Zhan Zhu, additional, Fu, Yu Lin, additional, and Yang, De Sheng, additional
- Published
- 2013
- Full Text
- View/download PDF
48. Pseudomonas aeruginosa Necrotizing Fasciitis in a Patient with Methimazole-Induced Agranulocytosis
- Author
-
Hsu-Tang Cheng and Fu-Yu Lin
- Subjects
Methimazole ,business.industry ,Pseudomonas aeruginosa ,General Medicine ,medicine.disease ,medicine.disease_cause ,Hyperthyroidism ,Anti-Bacterial Agents ,Microbiology ,Diagnosis, Differential ,Antithyroid Agents ,Debridement ,Humans ,Medicine ,Female ,Pseudomonas Infections ,Fasciitis, Necrotizing ,business ,Fasciitis ,Aged ,Agranulocytosis ,Follow-Up Studies ,medicine.drug - Published
- 2011
49. Establishment of osteoblast-specific Cre transgenic mice
- Author
-
Pei-Tang Huang, Ning Hou, Tu-Jun Weng, Xiao Yang, Fu-Yu Lin, Jing Wang, Xiaohong Tan, and Xuan Cheng
- Subjects
Male ,Genetically modified mouse ,Microinjections ,Transgene ,Osteocalcin ,Cre recombinase ,Mice, Transgenic ,Biology ,Polymerase Chain Reaction ,law.invention ,Mice ,chemistry.chemical_compound ,law ,Animals ,Humans ,Promoter Regions, Genetic ,Gene ,Southern blot ,Osteoblasts ,Integrases ,Human Growth Hormone ,General Medicine ,Molecular biology ,genomic DNA ,chemistry ,Recombinant DNA ,Female ,DNA ,Plasmids - Abstract
An osteoblast-specific Cre transgenic construct (pOC-Cre) containing the osteocalcin promoter, Cre recombinase gene and polyA of human growth hormone gene was generated. The 4.6 kb DNA fragment of OC-Cre was introduced into fertilized zygotes by microinjection. 2 out of 16 offspring were identified as founders carrying the transgene by PCR and Southern blot analysis, and the integration efficiency is 12.5 %. To check the tissue distribution of the OC-Cre, the OC-Cre transgenic founder mice were bred with the mice carrying Smad4 conditional alleles. PCR results showed that the genomic DNA fragments after Cre mediated recombination could be only amplified from bone tissues of the transgenic mice. LacZ staining of OC-Cre; ROSA26 double transgenic mice revealed that Cre recombinase expressed in osteoblasts and mediated DNA recombination between LoxP sites at the ROSA26 locus. All these data indicated that the Cre recombinase was ex-pressed in the osteoblasts of the OC-Cre transgenic mice and could mediate DNA recombination between LoxP sites. The OC-Cre transgenic mice we generated in this study could serve as a useful tool for generating osteoblast specific gene-knockout mice.
- Published
- 2007
50. Virtual Impedance Analyzer Design and Implementation.
- Author
-
Kai-chao Yao, Chin-wen Liao, Li-ling Chao, and Fu-yu Lin
- Published
- 2007
- Full Text
- View/download PDF
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