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This paper discusses co-housing and its role as sustainable architecture to support various aspects of the life of communities and the environment. This research is important because the potential of co-housing settlements to improve the social and mental well-being of their residents has not been widely discussed. In addition, housing that uses sustainable technology tends to be very expensive, which, in the end, makes it more difficult for cultural communities to access settlements. For this reason, this study aims to demonstrate how the co-housing concept can address the issues mentioned earlier. To achieve this, a qualitative approach is employed, with the Miss Tjitjih (MT) community selected as the case study. The MT community was chosen because it has been living in co-housing concept housing for more than four decades. Open-ended questions were given to reveal opinions from the participant's side. The answers from the participants are then analyzed with the help of Nvivo. The results of the analysis are then grouped to obtain a code that explains the role of co-housing for this community. The resulting diagram reveals the role of co-housing as a settlement model that can answer various problems of cultural communities in the city. [ABSTRACT FROM AUTHOR]

The government of the Education Office of North Maluku Province is trying to overcome the problem of student distribution for schools in the city of Ternate, especially SMA/SMK/equivalent which aims to make all schools quality and there are no more superior schools. However, new problems arise related to the zoning system itself, sometimes some parents of prospective students and prospective students themselves do not know the schools in their domicile zone. The problem formulation is how to create and compile a Geographic Information System Mapping SMA and SMK in Ternate City. Designing a geographic information system that can provide information about web-based SMA and SMK Mapping in Ternate City and become a reference for the community in choosing their or their children's schools according to the zoning system. For testing the system is in accordance with the stages tested where for testing the system is used black box testing, namely testing to see the suitability of data accessed. The high school and vocational recession geographic information system was built using the PHP programming language, Mysql as a database, while for making locations of high school and vocational high school vulnerable places using google maps, maps API. All high school and vocational tracking information system uploads use black boxes, run as expected on the system upload carried out. From the results of this design, it will make it easier for parents to find information on SMA and SMK schools, such as the domicile zone of the school where they live. [ABSTRACT FROM AUTHOR]

The Information and Communication Technology Unit (ICTU) is a technical implementation unit in the field of information and communication technology development and management. Currently, Khairun University's ICTU is undertaking a software development project, one of which involves creating an application called "Permata". In the process of developing this application, one of the common challenges faced is estimating the project costs for software development, as the developers do not yet have a standard method to determine the costs of software development. The objective of this research is to produce a Use Case Point application for estimating the costs of software development at ICTU, Khairun University. The Use Case Point (UCP) method is derived from the Function Point Analysis (FPA) method and aims to provide a simple estimation method oriented toward software project objects. The software objects involved in this method are Actor Types (UAW), Use Case Weight (UUCW), Technical System Development Complexity (TF), and Development Environment Complexity (EF). The estimated time value for developing the Permata application is 1,389.844855 man-hours, equivalent to approximately 1.904 months. The estimated cost for the Permata application is Rp129,099,127. [ABSTRACT FROM AUTHOR]

In the pursuit of technologically advanced governance, the Ministry ABC has integrated technology into daily operations, particularly through web applications like an employee administration information system. However, challenges persist in the implementation of online administration, especially in terms of technology adoption among the older generation. This study employs the Technology Acceptance Model (TAM) to investigate the usage of the administrative information system, focusing on System Quality (SQ), Perceived Ease of Use (EU), Perceived Usefulness (PU), and Behavioral Intention (BI). Surveying 147 respondents via questionnaires, the findings reveal that system quality positively influences perceived ease of use and perceived usefulness, while unexpectedly establishing a negative relationship between system quality, perceived ease of use, perceived usefulness, and behavioral intention. These insights hold significance for both theory and practice, reaffirming the crucial roles of perceived ease of use and perceived usefulness in shaping behavioral intentions and augmenting the TAM model. [ABSTRACT FROM AUTHOR]

The amount of rainfall that occurs cannot be determined with certainty, but it can be predicted or estimated. In predicting the potential for rain, data mining techniques can be used by classifying data using the naive Bayes method. Naïve Bayes algorithm is a classification method using probability and statistical methods. The purpose of this study is how to implement the naive Bayes method to predict the potential for rain in Ternate City, and be able to calculate the accuracy of the Naive Bayes method from system created. The highest calculation results with new data with a total of 400 training data and 30 test data, obtained 30 correct data with 100% precision, 100% recall and 100% accuracy and the lowest calculation results with new data with a total of 500 training data and 50 test data, obtained 38 correct data and 12 incorrect data with a percentage of precision 61.29%, recall 100% and accuracy 76%.

How do we reveal hidden structures within a complicated web of social interactions? How can we explain the complex nexus of relationships in a public space? In this paper, we offer a different perspective on urban structures by using a multi-layer perspective to understand the structure of space that emerges from the complex uses of spaces. We particularly benefit from the concept of nesting as the theoretical lens in our research. We use a popular urban leisure space in Jakarta as a case study: The Hotel Indonesia (HI) Roundabout during Car Free Day Sunday events. We reveal that within this particular event, there are nested smaller events. The nesting structure also demonstrates how events and activities overlap within a single setting. The nesting approach provides us with a chance to seek an alternative structure for urban spaces. [ABSTRACT FROM AUTHOR]

Background: Hepatitis C virus (HCV) is a major cause of liver disease and a potential cause of substantial morbidity and mortality worldwide. The overall prevalence of HCV infection is 2%, representing 120 million people worldwide. Current standard treatment using pegylated interferon and ribavirin is effective in only 50% of the patients infected with HCV genotype 1, and is associated with significant side effects. Therefore, it is still of importance to develop new drugs for treatment of HCV. Antiviral substances obtained from natural products, including medicinal plants, are potentially good targets to study. In this study, we evaluated Indonesian medicinal plants for their anti-HCV activities. Methods: Ethanol extracts of 21 samples derived from 17 species of medicinal plants explored in the East Java region were tested. Anti-HCV activities were determined by a cell culture method using Huh7.5 cells and HCV strains of 9 different genotypes (1a to 7a, 1b and 2b). Results: Four of the 21 samples tested showed antiviral activities against HCV: Toona sureni leaves (TSL) with 50% inhibitory concentrations (IC50) of 13.9 and 2.0 μg/ml against the HCV J6/JFH1-P47 and -P1 strains, respectively, Melicope latifolia leaves (MLL) with IC50 of 3.5 and 2.1 μg/ml, respectively, Melanolepis multiglandulosa stem (MMS) with IC50 of 17.1 and 6.2 μg/ml, respectively, and Ficus fistulosa leaves (FFL) with IC50 of 15.0 and 5.7 μg/ml, respectively. Time-of-addition experiments revealed that TSL and MLL inhibited both at the entry and post-entry steps while MMS and FFL principally at the entry step. TSL and MLL inhibited all of 11 HCV strains of all the genotypes tested to the same extent. On the other hand, FFL showed significantly weaker inhibitory activities against the HCV genotype 1a strain, and MMS against the HCV strains of genotypes 2b and 7a to a lesser extent, compared to the other HCV genotypes. Conclusions: Ethanol extracts of TSL, MLL, MMS and FFL showed antiviral activities against all the HCV genotypes tested with the exception that some genotype(s) showed significant resistance to FFL and to MMS to a lesser extent. These plant extracts may be good candidates for the development of anti-HCV drugs. [ABSTRACT FROM AUTHOR]

Hepatitis C virus (HCV) infection is highly prevalent among global populations, with an estimated number of infected patients being 170 million. Approximately 70–80% of patients acutely infected with HCV will progress to chronic liver disease, such as liver cirrhosis and hepatocellular carcinoma, which is a substantial cause of morbidity and mortality worldwide. New therapies for HCV infection have been developed, however, the therapeutic efficacies still need to be improved. Medicinal plants are promising sources for antivirals against HCV. A variety of plants have been tested and proven to be beneficial as antiviral drug candidates against HCV. In this study, we examined extracts, their subfractions and isolated compounds of Ruta angustifolia leaves for antiviral activities against HCV in cell culture. We isolated six compounds, chalepin, scopoletin, γ-fagarine, arborinine, kokusaginine and pseudane IX. Among them, chalepin and pseudane IX showed strong anti-HCV activities with 50% inhibitory concentration (IC 50 ) of 1.7 ± 0.5 and 1.4 ± 0.2 μg/ml, respectively, without apparent cytotoxicity. Their anti-HCV activities were stronger than that of ribavirin (2.8 ± 0.4 μg/ml), which has been widely used for the treatment of HCV infection. Mode-of-action analyses revealed that chalepin and pseudane IX inhibited HCV at the post-entry step and decreased the levels of HCV RNA replication and viral protein synthesis. We also observed that arborinine, kokusaginine and γ-fagarine possessed moderate levels of anti-HCV activities with IC 50 values being 6.4 ± 0.7, 6.4 ± 1.6 and 20.4 ± 0.4 μg/ml, respectively, whereas scopoletin did not exert significant anti-HCV activities at 30 μg/ml. [ABSTRACT FROM AUTHOR]

Background: Hepatitis C virus (HCV) is a major cause of liver disease and a potential cause of substantial morbidity and mortality worldwide. The overall prevalence of HCV infection is 2%, representing 120 million people worldwide. Current standard treatment using pegylated interferon and ribavirin is effective in only 50% of the patients infected with HCV genotype 1, and is associated with significant side effects. Therefore, it is still of importance to develop new drugs for treatment of HCV. Antiviral substances obtained from natural products, including medicinal plants, are potentially good targets to study. In this study, we evaluated Indonesian medicinal plants for their anti-HCV activities., Methods: Ethanol extracts of 21 samples derived from 17 species of medicinal plants explored in the East Java region were tested. Anti-HCV activities were determined by a cell culture method using Huh7.5 cells and HCV strains of 9 different genotypes (1a to 7a, 1b and 2b)., Results: Four of the 21 samples tested showed antiviral activities against HCV: Toona sureni leaves (TSL) with 50% inhibitory concentrations (IC50) of 13.9 and 2.0 μg/ml against the HCV J6/JFH1-P47 and -P1 strains, respectively, Melicope latifolia leaves (MLL) with IC50 of 3.5 and 2.1 μg/ml, respectively, Melanolepis multiglandulosa stem (MMS) with IC50 of 17.1 and 6.2 μg/ml, respectively, and Ficus fistulosa leaves (FFL) with IC50 of 15.0 and 5.7 μg/ml, respectively. Time-of-addition experiments revealed that TSL and MLL inhibited both at the entry and post-entry steps while MMS and FFL principally at the entry step. TSL and MLL inhibited all of 11 HCV strains of all the genotypes tested to the same extent. On the other hand, FFL showed significantly weaker inhibitory activities against the HCV genotype 1a strain, and MMS against the HCV strains of genotypes 2b and 7a to a lesser extent, compared to the other HCV genotypes., Conclusions: Ethanol extracts of TSL, MLL, MMS and FFL showed antiviral activities against all the HCV genotypes tested with the exception that some genotype(s) showed significant resistance to FFL and to MMS to a lesser extent. These plant extracts may be good candidates for the development of anti-HCV drugs.