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The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework. LAG-R aims to document animals' genetic makeup in scientific publications, providing essential details for replication and appropriate model use. While verifying complete genetic compositions may be impractical, better reporting and validation efforts enhance reliability of research. LAG-R standardization will bolster reproducibility, peer review, and overall scientific rigor., (© 2024. The Author(s).)

Primary segmentation in vertebrates is considered to be an intrinsic property of the presomitic paraxial mesoderm controlled by a number of interconnected oscillating signals. Re-segmentation, in contrast, has been shown to depend on signals from the axial structures. Here we report the requirement of the neural tube for maintenance but not formation of primary segmentation in chick embryos. Unilateral removal of the neural tube, next to the anterior presomitic mesoderm, caused disturbed development of the neural arches and the spinous processes. But already 24 h postsurgery, the sclerotome showed loss of primary segmentation in the craniocaudal axis. Cells strongly expressing twist and not showing any segmentation were located dorsomedially between the remaining left half of the neural tube and the right side dermomyotome, which frequently was truncated medially., (Copyright (c) 2006 S. Karger AG, Basel.)