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4 results on '"Fuhong Yan"'

1. RBF and NSGA-II based EDM process parameters optimization with multiple constraints

Author

Xiaoke Li, Fuhong Yan, Jun Ma, Zhenzhong Chen, Xiaoyu Wen, and Yang Cao

Subjects
edm, process parameter optimization, rbf, nsga-ii, Biotechnology, TP248.13-248.65, Mathematics, QA1-939
Abstract

In this study, the radial basis function (RBF) which has good performance for nonlinear problem is introduced to approximate the implicit relationships between EDM parameters and performance responses for 304 steel. The fitting precision of RBF is compared with the second order polynomial response surface (PRS), support vector regression (SVR) and Kriging model (KRG) using the multiple correlation coefficient (R2) based cross validation error method. Then the RBF model is called to conduct multi-objective optimization using non-dominated sorting genetic algorithm II (NSGA-II) method. The energy consumption index unit energy consumption (UEC) and the air-pollution indices PM2.5 and PM10 are considered in proposed multi-objective optimization model. UEC is considered as the objective function to reduce the machining cost and the PM indices are termed as the constraints to protect the operators' health. The pulse current, time period and duty cycle are considered as the main factors affecting the EDM responses. According to the Pareto plots of multi-objective optimization model, conclusion can be drawn that SR and PM10 play significant roles in multi-optimization and PM2.5 has less influence on optimization results. The results of the present study reveal that using maximum material removal rate (MRR) and minimum UEC as objective and using surface roughness (SR), PM2.5 and PM10 as constraints can be an effective method to provide appropriate process parameters reference for EDM machining.

Published
2019
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2. Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II

Author

Fuhong Yan, Xiaobei Feng, Nan Chen, Wei-ming Wang, Wen Zhang, Chong Zhang, Zhaohui Wang, and Jingyuan Xie

Subjects
Nephrology, Adult, Male, medicine.medical_specialty, China, Physiology, Pseudohypoaldosteronism, Receptors, Drug, Blotting, Western, DNA Mutational Analysis, Molecular Sequence Data, Mutation, Missense, Biology, Protein Serine-Threonine Kinases, medicine.disease_cause, Asian People, Physiology (medical), Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Solute Carrier Family 12, Member 3, Amino Acid Sequence, Pseudohypoaldosteronism Type 2, Child, Aged, Genetics, Family Health, Mutation, Microscopy, Confocal, Base Sequence, Sequence Homology, Amino Acid, Symporters, urogenital system, Kinase, Wnk kinase, General Medicine, Middle Aged, WNK1, medicine.disease, WNK4, Pedigree, HEK293 Cells, Female
Abstract

Background: It has been reported that mutations in WNK1 and WNK4 cause pseudohypoaldosteronism type II (PHA2), an autosomal dominant renal disease. WNK kinase proteins are expressed in the kidney and regulate ion transport including the thiazide-sensitive sodium chloride cotransporter (NCC). In this report, we screened 4 Chinese PHA2 pedigrees for WNK4 mutations, identified a novel mutation, and studied its effects on NCC protein trafficking in vitro. Methods: The patients’ genomic DNA was extracted from peripheral leukocytes. Sequence analysis was performed by PCR amplification of the 19 exons of WNK4. The wild-type or mutant WNK4 was coexpressed with NCC in HEK293 cells. We measured the effect of wild-type WNK4 compared to the mutant WNK4 on NCC protein surface expression. Results: A novel missense mutation in WNK4, K1169E, was identified in 1 of the 4 pedigrees. Analysis of confocal images showed that K1169E lost its inhibitory effect on NCC surface expression compared to wild-type WNK4 when expressed in HEK293 cells, while it did not change NCC total protein expression. Conclusions: We identified an unreported disease-causing WNK4 missense mutation, K1169E, in 1 Chinese PHA2 pedigree. This mutation appears to be a ‘loss of function’ of NCC inhibition and suggests that some important functional roles lie in the 2nd coiled-coil domain of WNK4.

Published
2010

3. Two brothers in one Chinese family with collagen type III glomerulopathy

Author

Xiaoxia Pan, Fuhong Yan, Xiaobei Dong, Yaowen Xu, Hao Shi, Zhaohui Wang, and Nan Chen

Subjects
Nephrology, Adult, Male, medicine.medical_specialty, China, business.industry, Biopsy, Kidney Glomerulus, medicine.disease, Pedigree, Type III Procollagen, Procollagen type III, Collagen Type III, Endocrinology, Glomerulonephritis, Asian People, Glomerulopathy, Internal medicine, medicine, Humans, Chinese family, business
Published
2006

4. A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative

Author

Changkuo Zhao, Xianheng Wang, Fuhong Yang, Lei Gao, and Yuhe Wang

Subjects
camptothecin, norcantharidin, synthesis, water solubility, tumour, Science
Abstract

A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines.

Published
2018
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