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836 results on '"Fujimoto, Shinji"'

4. Mice deficient in the phosphatase activity of sEH show decreased levels of the endocannabinoid 2‐AG in the olfactory bulb and depressive‐like behavior.

Author

Oguro, Ami, Kaga, Yurino, Sato, Hideaki, Fujiyama, Taichi, Fujimoto, Shinji, Nagai, Saki, Matsuyama, Makoto, Miyara, Masatsugu, Ishihara, Yasuhiro, Yamazaki, Takeshi, Imaoka, Susumu, and Kotake, Yaichiro

Subjects
EPOXIDE hydrolase, OLFACTORY bulb, LYSOPHOSPHOLIPIDS, ACID phosphatase, CRISPRS
Abstract

Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that has epoxide hydrolase activity and phosphatase activity. Our earlier study revealed that lysophosphatidic acids are a substrate of the phosphatase activity of sEH in vitro, but its physiological function remained unknown. Herein, we used the CRISPR/Cas9 system and i‐GONAD method to generate mice that are deficient in sEH phosphatase activity. In the mouse brain, sEH was highly expressed in the olfactory bulb. Deletion of the sEH phosphatase activity resulted in decreased levels of the endocannabinoid 2‐arachidonoyl glycerol (2‐AG), which is a dephosphorylated form of 2‐arachidonoyl‐lysophosphatidic acid in the olfactory bulb. The sEH‐deficient mice showed depressive‐like behavior. These results indicate that sEH can regulate the production of 2‐AG and brain function in vivo. [ABSTRACT FROM AUTHOR]

Published
2024
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6. CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate

Author

Suzuki, Toshimitsu, Tatsukawa, Tetsuya, Sudo, Genki, Delandre, Caroline, Pai, Yun Jin, Miyamoto, Hiroyuki, Raveau, Matthieu, Shimohata, Atsushi, Ohmori, Iori, Hamano, Shin-ichiro, Haginoya, Kazuhiro, Uematsu, Mitsugu, Takahashi, Yukitoshi, Morimoto, Masafumi, Fujimoto, Shinji, Osaka, Hitoshi, Oguni, Hirokazu, Osawa, Makiko, Ishii, Atsushi, Hirose, Shinichi, Kaneko, Sunao, Inoue, Yushi, Moore, Adrian Walton, and Yamakawa, Kazuhiro

Published
2022
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14. TiO2 nanotubes with customized diameters for local drug delivery systems.

Author

Miyabe, Sayaka, Fujinaga, Yushi, Tsuchiya, Hiroaki, and Fujimoto, Shinji

Subjects
DRUG delivery systems, NANOTUBES, DIAMETER
Abstract

In this study, we evaluated the drug release behavior of diameter customized TiO2 nanotube layers fabricated by anodization with various applied voltage sequences: conventional constant applied potentials of 20 V (45 nm) and 60 V (80 nm), a 20/60 V stepped potential (50 nm [two‐diameter]), and a 20–60 V swept potential (49 nm [full‐tapered]) (values in parentheses indicate the inner tube diameter at the top part of nanotube layers). The structures of the 50 nm (two‐diameter) and 49 nm (full‐tapered) samples had smaller inner diameters at the top part of nanotube layers than that of the 80 nm sample, while the outer diameters at the bottom part of nanotube layers were almost the same size as the 80 nm sample. The 80 nm sample, which had the largest nanotube diameter and length, exhibited the greatest burst release, followed by the 50 nm (two‐diameter), 49 nm (full‐tapered), and 45 nm samples. The initial burst released drug amounts and release rates from the 50 nm (two‐diameter) and 49 nm (full‐tapered) samples were significantly suppressed by the smaller tube top. On the other hand, the largest proportion of the slow released drug amount to the total released drug amount was observed for the 50 nm (two‐diameter) sample. Thus, 50 nm (two‐diameter) achieved suppressed initial burst release and large storage capacity. Therefore, this study has, for the first time, applied TiO2 nanotube layers with modulated diameters (two‐diameter and full‐tapered) to the realization of a localized drug delivery system (LDDS) with customized drug release properties. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Corrosion behavior of carbon steel covered with a coating film containing metallic compounds under a sulfuric acid mist environment containing chloride.

Author

Takahashi, Masamitsu, Deguchi, Hiroshi, Hayashi, Yasunori, Kimura, Akihiko, Hanaki, Koushu, Tsuchiya, Hiroaki, Yamashita, Masato, and Fujimoto, Shinji

Subjects
CARBON steel corrosion, METALLIC films, CARBON steel, SURFACE coatings
Abstract

The corrosion behavior of carbon steel covered with coating films containing Al2(SO4)3, CaO, and BaO was examined under a sulfuric acid mist environment containing chloride. CaSO4･2H2O and BaSO4 were formed as the corrosion products in the coating film and prevented the penetration of corrosives, in particular BaSO4 was highly effective. Furthermore, the rust layer containing CaCO3 adhered to the carbon steel substrate suppressed the penetration of chloride. The formation of these corrosion products suppressed the anodic reaction, resulting in higher corrosion resistance of the carbon steel in the chloride‐containing acid environment. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy

Author

Bailey, Julia N., de Nijs, Laurence, Bai, Dongsheng, Suzuki, Toshimitsu, Miyamoto, Hiroyuki, Tanaka, Miyabi, Patterson, Christopher, Lin, Yu-Chen, Medina, Marco T., Alonso, María E., Serratosa, José M., Durón, Reyna M., Nguyen, Viet H., Wight, Jenny E., Martínez-Juárez, Iris E., Ochoa, Adriana, Jara-Prado, Aurelio, Guilhoto, Laura, Molina, Yolly, Yacubian, Elsa M., López-Ruiz, Minerva, Inoue, Yushi, Kaneko, Sunao, Hirose, Shinichi, Osawa, Makiko, Oguni, Hirokazu, Fujimoto, Shinji, Grisar, Thierry M., Stern, John M., Yamakawa, Kazuhiro, Lakaye, Bernard, and Delgado-Escueta, Antonio V.

Published
2018
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41. Structure of corrosion product formed on carbon steel covered with NiSO4-Added resin coating under sulfuric acid mist environment containing chloride

Author

Hayashida, Shota, Takahashi, Masamitsu, Deguchi, Hiroshi, Tsuchiya, Hiroaki, Hanaki, Koushu, Yamashita, Masato, and Fujimoto, Shinji

Subjects
Magnetite, Sulfuric acid mist, Carbon steel, Corrosion product, Goethite, Akaganeite, Metallic salt
Abstract

Shota Hayashida, Masamitsu Takahashi, Hiroshi Deguchi, Hiroaki Tsuchiya, Koushu Hanaki, Masato Yamashita, Shinji Fujimoto, Structure of Corrosion Product Formed on Carbon Steel Covered with NiSO4-Added Resin Coating under Sulfuric Acid Mist Environment Containing Chloride, Materials Transactions, 2021, Volume 62, Issue 6, Pages 781-787, Released on J-STAGE May 25, 2021, Advance online publication May 14, 2021, Online ISSN 1347-5320, Print ISSN 1345-9678, https://doi.org/10.2320/matertrans.C-M2021819., Corrosion resistance of carbon steel covered with resin coating containing nickel sulfate has been evaluated under chloride and sulfuric acid mist environment. The structure of corrosion products formed on steel surface was investigated by XRD and XAFS analyses using synchrotron radiation. Nickel sulfate promoted the formation of goethite and akaganeite. It was considered that this akaganeite was not tetragonal β-FeOOH but monoclinic akaganeite containing nickel.

Published
2021

49. Drug Release Characteristic of Type 316L Stainless Steel with Self-Organized Nanopores

Author

Miyabe, Sayaka, Fujinaga, Yushi, Tsuchiya, Hiroaki, and Fujimoto, Shinji

Subjects
Nanopore, Biomaterials, Nanostructure, Local Drug Delivery System, Anodic Polarization
Abstract

Drug-releasing implants are attracting attention as a local drug delivery system（LDDS）with high drug efficiency and few side effects because they can administer drugs locally and continuously. Since the surface structure of implants is important for drug- releasing implants, many research reports have been made using metallic surfaces with nanostructures such as TiO 2 nanotubes as the platform for LDDS. In present study, we investigated drug release characteristic of collagen coated Type 316L stainless steel with self-organized nanopores formed by anodic polarization. Regardless of whether or not nanopore structure, the collagen coating treatment increased the amount of drug loaded on samples. The samples with nanopore structure suppressed burst release and increased the rate of slow release.

Published
2021

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