671 results on '"Fukami, Tatsuki"'
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2. Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone
3. Cytochrome P450 and UDP-Glucuronosyltransferase Expressions, Activities, and Induction Abilities in 3D-Cultured Human Renal Proximal Tubule Epithelial Cells
4. Iminium ion metabolites are formed from nintedanib by human CYP3A4
5. Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation
6. Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology
7. Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine
8. Activation of Inflammation by MCF-7 Cells-Derived Small Extracellular Vesicles (sEV): Comparison of Three Different Isolation Methods of sEV
9. NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction
10. In Vitro Evaluation of the Reductase Activities of Human AKR1C3 Allelic Variants
11. ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver
12. Evaluation of Drug-Drug Interactions via Inhibition of Hydrolases by Orlistat, an Anti-Obesity Drug
13. Development and Validation of a Proteomic Correlation Profiling Technique to Detect and Identify Enzymes Involved in Metabolism of Drugs of Concern
14. Characterization of Enzymes Involved in Nintedanib Metabolism in Humans
15. Utility of a Systematic Approach to Selecting Candidate Prodrugs: A Case Study Using Candesartan Ester Analogues
16. Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism
17. Quantitative Evaluation of the Contribution of Each Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoform to Reduction Reactions of Compounds Containing a Ketone Group in the Human Liver
18. Adenosine N6-methylation upregulates the expression of human CYP2B6 by altering the chromatin status
19. Methionine Sulfoxide Reductase A in Human and Mouse Tissues is Responsible for Sulindac Activation, Making a Larger Contribution than the Gut Microbiota
20. PPARα regulates the expression of human arylacetamide deacetylase involved in drug hydrolysis and lipid metabolism
21. Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency
22. Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans
23. m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2
24. Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans
25. Characteristics of miRNA-SNPs in healthy Japanese subjects and non-small cell lung cancer, colorectal cancer, and soft tissue sarcoma patients
26. Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase
27. The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression
28. Identification of miRNAs that regulate human CYP2B6 expression
29. Hydrolase activities of cynomolgus monkey liver microsomes and recombinant CES1, CES2, and AADAC
30. Role of Human Arylacetamide Deacetylase (AADAC) on Hydrolysis of Eslicarbazepine Acetate and Effects of AADAC Genetic Polymorphisms on Hydrolase Activity
31. Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor
32. Systematic Approach for Screening of Prodrugs: Evaluation Using Oseltamivir Analogues as Models
33. Human superoxide dismutase 1 attenuates quinoneimine metabolite formation from mefenamic acid
34. Identification of an isoform catalyzing the CoA conjugation of nonsteroidal anti-inflammatory drugs and the evaluation of the expression levels of acyl-CoA synthetases in the human liver
35. Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers
36. A Novel Systematic Approach for Selection of Prodrugs Designed to Improve Oral Absorption
37. SLC35B1 significantly contributes to the uptake of UDPGA into the endoplasmic reticulum for glucuronidation catalyzed by UDP-glucuronosyltransferases
38. A new trapping method to quantitatively assess the formation of reactive metabolites from drugs which cause agranulocytosis
39. Strain and sex differences in drug hydrolase activities in rodent livers
40. Methylation of adenosine at the N6 position post-transcriptionally regulates hepatic P450s expression
41. Adenosine Deaminases Acting on RNA Downregulate the Expression of Constitutive Androstane Receptor in the Human Liver–Derived Cells by Attenuating Splicing
42. Characterization of human UGT2A3 expression using a prepared specific antibody against UGT2A3
43. RNA Editing Enzymes Modulate the Expression of Hepatic CYP2B6, CYP2C8, and Other Cytochrome P450 Isoforms
44. Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model
45. Quantitative Analysis of UDP-Glucuronosyltransferase Ugt1a and Ugt2b mRNA Expression in the Rat Liver and Small Intestine: Sex and Strain Differences
46. Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs
47. In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury
48. miR-141-3p commonly regulates human UGT1A isoforms via different mechanisms
49. Identification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injury
50. Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans
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