Search

Your search keyword '"Fukushima, Ai"' showing total 39 results
Start Over Author "Fukushima, Ai"
39 results on '"Fukushima, Ai"'

16. Immunofluorescence analysis of DNA damage response protein p53-binding protein 1 in a case of uterine dedifferentiated leiomyosarcoma arising from leiomyoma

Author

Matsuda, Katsuya, primary, Akazawa, Yuko, additional, Yamaguchi, Yuka, additional, Mussazhanova, Zhanna, additional, Kurohama, Hirokazu, additional, Ueki, Nozomi, additional, Kohno, Michiharu, additional, Fukushima, Ai, additional, Kajimura, Itsuki, additional, Hiraki, Hiroko, additional, Matsuwaki, Takahiro, additional, Kawashita, Sayaka, additional, Kinoshita, Akira, additional, and Nakashima, Masahiro, additional

Published
2019
Full Text
View/download PDF

19. Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature

Author

Matsuda, Katsuya, Tateishi, Seiko, Akazawa, Yuko, Kinoshita, Akira, Yoshida, Shiko, Morisaki, Sachiko, Fukushima, Ai, Matsuwaki, Takahiro, Yoshiura, Koh-Ichiro, Nakashima, Masahiro, Matsuda, Katsuya, Tateishi, Seiko, Akazawa, Yuko, Kinoshita, Akira, Yoshida, Shiko, Morisaki, Sachiko, Fukushima, Ai, Matsuwaki, Takahiro, Yoshiura, Koh-Ichiro, and Nakashima, Masahiro

Abstract

Background: Mitotically active cellular fibroma (MACF) of the ovary, characterized by relatively high mitotic activity without severe atypia, represents a relatively new disease entity. MACF is categorized as a benign ovarian tumor. However, due to a limited number of case reports, its clinical and pathological features and optimum management remains largely undetermined. Herein, we report on a rare case of MACF that grew rapidly in size and was diagnosed on detailed pathological examination. Case presentation: A 44-year-old Japanese woman, who detected a myoma-like lesion 1-year earlier, was referred to our hospital when the follow-up examination demonstrated that the mass had increased in size. Magnetic resonance imaging revealed a T1 isointense and T2 hyperintense tumor (11 cm in diameter) in the right pelvic cavity. Laparoscopy confirmed the presence of a right ovarian tumor and laparoscopic right adnexectomy was performed. The tumor cells consisted of dense cellular proliferations of spindle fibroblast-like cells without significant cytological atypia. The mitotic activity index was estimated at >15 mitotic figures per 10 high-power fields. Reticulin staining and FOXL2 mutation analysis excluded the possibility of an adult granulosa cell tumor, and the patient was diagnosed with a MACF of the ovary. Conclusions: To the best of our knowledge, we are the first to report on a case of rapid growth of a MACF of the ovary during follow-up. When an increase in the size of a solid ovarian mass is detected, a MACF should be considered as a differential diagnosis., Diagnostic Pathology, 11, 101; 2016

Published
2016

23. Novel recessive mutations in MSTO1cause cerebellar atrophy with pigmentary retinopathy

Author

Iwama, Kazuhiro, Takaori, Toru, Fukushima, Ai, Tohyama, Jun, Ishiyama, Akihiko, Ohba, Chihiro, Mitsuhashi, Satomi, Miyatake, Satoko, Takata, Atsushi, Miyake, Noriko, Ito, Shuichi, Saitsu, Hirotomo, Mizuguchi, Takeshi, and Matsumoto, Naomichi

Abstract

Misato 1, mitochondrial distribution and morphology regulator (encoded by the MSTO1gene), is involved in mitochondrial distribution and morphology. Recently, MSTO1mutations have been shown to cause clinical manifestations suggestive of mitochondrial dysfunction, such as muscle weakness, short stature, motor developmental delay, and cerebellar atrophy. Both autosomal dominant and recessive modes of inheritance have been suggested. We performed whole-exome sequencing in two unrelated patients showing cerebellar atrophy, intellectual disability, and pigmentary retinopathy. Three novel mutations were identified: c.836 G > A (p.Arg279His), c.1099-1 G > A (p.Val367Trpfs*2), and c.79 C > T (p.Gln27*). Both patients had compound heterozygous mutations with a combination of protein-truncation mutation and missense mutation, the latter shared by them both. This survey of two patients with recessive and novel MSTO1mutations provides additional clinical and genetic information on the pathogenicity of MSTO1in humans.

Published
2018
Full Text
View/download PDF

24. Somatotopical relationships between cortical activity and reflex areas in reflexology: A functional magnetic resonance imaging study

Author

Nakamaru, Tomomi, Miura, Naoki, Fukushima, Ai, Kawashima, Ryuta, Nakamaru, Tomomi, Miura, Naoki, Fukushima, Ai, and Kawashima, Ryuta

Abstract

We examined the somatotopical relationship between cortical activity and sensory stimulation of reflex areas in reflexology using functional magnetic resonance imaging. Three reflex areas on the left foot, relating to the eye, shoulder, and small intestine were stimulated during the experiment. A statistical analysis showed that reflexological stimulation of the foot reflex areas corresponding to the eye, shoulder, and small intestine activated not only the somatosensory areas corresponding to the foot, but also the somatosensory areas corresponding to the eye, shoulder, and small intestine or neighboring body parts. Thus, the findings showed that reflexological stimulation induced a somatosensory process corresponding to the stimulated reflex area and that a neuroimaging approach can be used to examine the basis of reflexology effects., journal article

Published
2008

33. Trial of intraventricular ribavirin therapy for subacute sclerosing panencephalitis in Japan

Author

Tomoda, Akemi, primary, Nomura, Keiko, additional, Shiraishi, Seiji, additional, Hamada, Akinobu, additional, Ohmura, Takafumi, additional, Hosoya, Mitsuaki, additional, Miike, Teruhisa, additional, Sawaishi, Yukio, additional, Kimura, Hiroshi, additional, Takashima, Hiroshi, additional, Tohda, Yoshihiro, additional, Mori, Kenji, additional, Kato, Zenichiro, additional, Fukushima, Ai, additional, Nishio, Hisanori, additional, Nezu, Akio, additional, and Nihei, Kenji, additional

Published
2003
Full Text
View/download PDF

34. Nihon Shoni Jinzobyo Gakkai Zasshi

Author

Fukushima, Ai, primary, Tanaka, Yasuki, additional, Hoshina, Satoshi, additional, Fujinaka, Hidehiko, additional, Hayakawa, Hiroshi, additional, and Tomizawa, Shyuichi, additional

Published
2001
Full Text
View/download PDF

35. Nihon Shoni Jinzobyo Gakkai Zasshi

Author

Tomizawa, Shuichi, primary, Hayakawa, Hiroshi, additional, Fukushima, Ai, additional, Hoshina, Toru, additional, Fujinaka, Hidehiko, additional, Ookubo, Soichiro, additional, Uchiyama, Makoto, additional, Inui, Takuro, additional, Iguchi, Mitumasa, additional, Kamiya, Hisashi, additional, Okabe, Minoru, additional, Takeuchi, Hiroshi, additional, Furukawa, Seikyo, additional, and Mayumi, Mitufumi, additional

Published
2000
Full Text
View/download PDF

36. Challenges to Reintegration: A Qualitative Intrinsic Case-Study of Convicted Female Sex Traffickers.

Author

Love DA, Fukushima AI, Rogers TN, Petersen E, Brooks E, and Rogers CR

Abstract

Limited research focuses on the nature of the lived experiences of women engaged in sex trafficking. This study employed qualitative methods of in-depth structured interviews with ten convicted sex traffickers (ages 24-56; 100% identifying as female). Participants' lived experiences revealed circumstances that led them to trafficking, specific needs, and the stigmatization they faced after exiting economies tied to trafficking. Inductive analysis yielded three key barriers to reintegration success: limited choice; negative labeling; and unmet physical, emotional, and social needs. These findings enhance understanding of the factors influencing the successful reintegration of convicted female sex traffickers into mainstream society., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2023
Full Text
View/download PDF

37. Immunofluorescence analysis of DNA damage response protein p53-binding protein 1 in a case of uterine dedifferentiated leiomyosarcoma arising from leiomyoma.

Author

Matsuda K, Akazawa Y, Yamaguchi Y, Mussazhanova Z, Kurohama H, Ueki N, Kohno M, Fukushima A, Kajimura I, Hiraki H, Matsuwaki T, Kawashita S, Kinoshita A, and Nakashima M

Subjects
Cell Dedifferentiation genetics, Cell Transformation, Neoplastic genetics, Female, Fluorescent Antibody Technique, Genomic Instability genetics, Humans, Leiomyosarcoma genetics, Middle Aged, Neoplasms, Multiple Primary genetics, Uterine Neoplasms genetics, Leiomyoma pathology, Leiomyosarcoma pathology, Neoplasms, Multiple Primary pathology, Tumor Suppressor p53-Binding Protein 1 analysis, Uterine Neoplasms pathology
Abstract

Aims: Genomic instability has been indicated during the dedifferentiation process from leiomyoma (LM) to leiomyosarcoma (LMS). Previously, we have described that nuclear expression pattern of DNA damage response protein p53-binding protein 1 (53BP1), detected by immunofluorescence, reflects the magnitude of genomic instability during malignancy. Here, we present a case of LMS arising from LM with molecular analysis of 53BP1, which showed transitional magnitude of DNA damage response within a tumor., Methods and Results: A fifty-year-old female with abdominal mass underwent hysterectomy. Histologically, the tumor consisted of LMS with highly atypical multinucleated giant cells as well as an LM component with transitional atypical spindle cells in the border area. LMS showed diffuse nuclear staining of 53BP1 expression, which has been previously described as high DNA damage response pattern. In contrast, the LM component lacked 53BP1 immunoreactivity and focal expression was observed in transitional lesion. Furthermore, double-labelled immunofluorescence revealed co-localization of 53BP1 with p53 and Ki-67 in the LMS component, which indicated abnormal DNA damage response in proliferative state., Conclusions: This study revealed that diffuse-type 53BP1 expression may be beneficial to estimate genomic instability during dedifferentiation from LM to DLMS., (Copyright © 2019 The Authors. Published by Elsevier GmbH.. All rights reserved.)

Published
2019
Full Text
View/download PDF

38. [Case of 12-year-old boy with idiopathic recurrent neuralgic amyotrophy].

Author

Fukushima A, Sasaki M, Sugai K, and Tojo M

Subjects
Brachial Plexus Neuritis complications, Brachial Plexus Neuritis pathology, Child, Electromyography, Humans, Magnetic Resonance Imaging, Male, Muscle, Skeletal innervation, Muscle, Skeletal pathology, Recurrence, Shoulder, Shoulder Pain etiology, Tomography, X-Ray Computed, Brachial Plexus Neuritis diagnosis
Abstract

Here we report a 12-year-old boy with idiopathic neuralgic amyotrophy who had two episodes of shoulder pain followed by shoulder muscle atrophy and weakness at the age of 7 and 11 years, respectively. These symptoms were self-limited and disappeared within 9 months. During the second episode, electromyograph (EMG) revealed neurogenic changes in the deltoid muscle. Muscle imaging showed the right deltoid muscle atrophy with slightly high intensity areas on T1 and T2 weighted images in MRI. Muscle biopsy from the right deltoid muscle revealed neurogenic changes with denervating and reinnervating processes. Neuralgic amyotrophy is characterized by neuralgic pain followed by weakness and atrophy at a unilateral extremity and is usually self-limited. EMG and imaging studies showed focal neurogenic abnormalities, which were confirmed by muscle biopsy. Neuralgic amyotrophy usually occurs in young adults and it is very rare in children.

Published
2006

39. [Establishment of a brain perfusion single photon emission computed tomography database in children by statistical imaging analysis].

Author

Fukushima A, Kato A, Matsuda H, Sugai K, and Sasaki M

Subjects
Adolescent, Age Factors, Brain pathology, Brain Diseases diagnostic imaging, Child, Child, Preschool, Female, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Regional Blood Flow, Brain diagnostic imaging, Cerebrovascular Circulation, Cysteine analogs & derivatives, Organotechnetium Compounds, Radiopharmaceuticals, Tomography, Emission-Computed, Single-Photon statistics & numerical data
Abstract

We made a 3-dimensional, 99mTc-ECD brain perfusion single photon emission computed tomography (SPECT) database in children by a statistical analysis. We selected 52 individuals between 1 and 15 years of age whose brain SPECT and brain MRI findings were normal, and divided them into three age groups: 1-5, 6-10 and 11-15 years. By comparing databases obtained for each group, an age-dependent change of regional cerebral blood flow was investigated. The results showed that the relative blood flow increases in the frontal lobe and cerebeller hemisphere and decrease in the occipital lobe with increasing age, findings consistent with those of previous reports. This database enabled us to easily find 3-dimensional brain perfusion abnormality in individual patient by SPECT, and may help elucidate the pathophysiology of many brain disorders.

Published
2005

Catalog

Books, media, physical & digital resources
See catalog results