69 results on '"Fundação de Amparo à Pesquisa do Estado do Amazonas"'
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2. Creatine Supplementation in Patients With Intermittent Claudication.
- Author
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Fundação de Amparo à Pesquisa do Estado do Amazonas and Ademar Avelar de Almeida Junior, PhD
- Published
- 2019
3. Identification of constrained sequence elements across 239 primate genomes
- Author
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Natural Environment Research Council (UK), UK Research and Innovation, National Human Genome Research Institute (US), Fundación la Caixa, Vienna Science and Technology Fund, European Commission, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fonds de la Recherche Scientifique (Fédération Wallonie-Bruxelles), Fundação de Amparo à Pesquisa do Estado do Amazonas, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), German Research Foundation, Ministry of Science and Technology of Vietnam, Agencia Estatal de Investigación (España), Generalitat de Catalunya, Natural Sciences and Engineering Research Council of Canada, Canada Research Chairs, Wenner-Gren Foundation, Leakey Foundation, National Science Foundation (US), National Geographic Society, National Institute on Aging (US), Swedish Research Council, National Research Foundation Singapore, European Research Council, Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Kuderna, Lukas F. K. [0000-0002-9992-9295], Kuhlwilm, Martin [0000-0002-0115-1797], Valenzuela, Alejandro [0000-0001-6120-6246], Juan, David [0000-0003-1912-9667], Lizano, Esther [0000-0003-3304-9807], Navarro, Arcadi [0000-0003-2162-8246], Marqués-Bonet, Tomàs [0000-0002-5597-3075], Kuderna, Lukas F. K., Ulirsch, Jacob C., Rashid, Sabrina, Ameen, Mohamed, Sundaram, Laksshman, Hickey, Glenn, Cox, Anthony J., Gao, Hong, Kumar, Arvind, Aguet, Francois, Christmas, Matthew J., Clawson, Hiram, Haeussler, Maximilian, Janiak, Mareike C., Kuhlwilm, Martin, Orkin, Joseph D., Bataillon, Thomas, Manu, Shivakumara, Valenzuela, Alejandro, Bergman, Juraj, Rousselle, Marjolaine, Silva, Felipe Ennes, Agueda, Lidia, Blanc, Julie, Gut, Marta, Vries, Dorien de, Goodhead, Ian, Harris, R. Alan, Raveendran, Muthuswamy, Jensen, Axel, Chuma, Idriss S., Horvath, Julie E., Hvilsom, Christina, Juan, David, Frandsen, Peter, Schraiber, Joshua G., Melo, Fabiano R. de, Bertuol, Fabrício, Byrne, Hazel, Sampaio, Iracilda, Farias, Izeni, Valsecchi, João, Messias, Malu, Silva, Maria N. F. da, Trivedi, Mihir, Rossi, Rogerio, Hrbek, Tomas, Andriaholinirina, Nicole, Rabarivola, Clément J., Zaramody, Alphonse, Jolly, Clifford J., Phillips-Conroy, Jane, Wilkerson, Gregory, Abee, Christian, Simmons, Joe H., Fernandez-Duque, Eduardo, Kanthaswamy, Sree, Shiferaw, Fekadu, Wu, Dongdong, Zhou, Long, Shao, Yong, Zhang, Guojie, Keyyu, Julius D., Knauf, Sascha, Le, Minh D., Lizano, Esther, Merker, Stefan, Navarro, Arcadi, Nadler, Tilo, Khor, Chiea Chuen, Lee, Jessica, Tan, Patrick, Lim, Weng Khong, Kitchener, Andrew C., Zinner, Dietmar, Gut, Ivo, Melin, Amanda D., Guschanski, Katerina, Schierup, Mikkel Heide, Beck, Robin M. D., Karakikes, Ioannis, Wang, Kevin C., Umapathy, Govindhaswamy, Roos, Christian, Boubli, Jean P., Siepel, Adam, Kundaje, Anshul, Paten, Benedict, Lindblad-Toh, Kerstin, Rogers, Jeffrey, Marqués-Bonet, Tomàs, Farh, Kyle Kai-How, Natural Environment Research Council (UK), UK Research and Innovation, National Human Genome Research Institute (US), Fundación la Caixa, Vienna Science and Technology Fund, European Commission, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fonds de la Recherche Scientifique (Fédération Wallonie-Bruxelles), Fundação de Amparo à Pesquisa do Estado do Amazonas, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), German Research Foundation, Ministry of Science and Technology of Vietnam, Agencia Estatal de Investigación (España), Generalitat de Catalunya, Natural Sciences and Engineering Research Council of Canada, Canada Research Chairs, Wenner-Gren Foundation, Leakey Foundation, National Science Foundation (US), National Geographic Society, National Institute on Aging (US), Swedish Research Council, National Research Foundation Singapore, European Research Council, Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Kuderna, Lukas F. K. [0000-0002-9992-9295], Kuhlwilm, Martin [0000-0002-0115-1797], Valenzuela, Alejandro [0000-0001-6120-6246], Juan, David [0000-0003-1912-9667], Lizano, Esther [0000-0003-3304-9807], Navarro, Arcadi [0000-0003-2162-8246], Marqués-Bonet, Tomàs [0000-0002-5597-3075], Kuderna, Lukas F. K., Ulirsch, Jacob C., Rashid, Sabrina, Ameen, Mohamed, Sundaram, Laksshman, Hickey, Glenn, Cox, Anthony J., Gao, Hong, Kumar, Arvind, Aguet, Francois, Christmas, Matthew J., Clawson, Hiram, Haeussler, Maximilian, Janiak, Mareike C., Kuhlwilm, Martin, Orkin, Joseph D., Bataillon, Thomas, Manu, Shivakumara, Valenzuela, Alejandro, Bergman, Juraj, Rousselle, Marjolaine, Silva, Felipe Ennes, Agueda, Lidia, Blanc, Julie, Gut, Marta, Vries, Dorien de, Goodhead, Ian, Harris, R. Alan, Raveendran, Muthuswamy, Jensen, Axel, Chuma, Idriss S., Horvath, Julie E., Hvilsom, Christina, Juan, David, Frandsen, Peter, Schraiber, Joshua G., Melo, Fabiano R. de, Bertuol, Fabrício, Byrne, Hazel, Sampaio, Iracilda, Farias, Izeni, Valsecchi, João, Messias, Malu, Silva, Maria N. F. da, Trivedi, Mihir, Rossi, Rogerio, Hrbek, Tomas, Andriaholinirina, Nicole, Rabarivola, Clément J., Zaramody, Alphonse, Jolly, Clifford J., Phillips-Conroy, Jane, Wilkerson, Gregory, Abee, Christian, Simmons, Joe H., Fernandez-Duque, Eduardo, Kanthaswamy, Sree, Shiferaw, Fekadu, Wu, Dongdong, Zhou, Long, Shao, Yong, Zhang, Guojie, Keyyu, Julius D., Knauf, Sascha, Le, Minh D., Lizano, Esther, Merker, Stefan, Navarro, Arcadi, Nadler, Tilo, Khor, Chiea Chuen, Lee, Jessica, Tan, Patrick, Lim, Weng Khong, Kitchener, Andrew C., Zinner, Dietmar, Gut, Ivo, Melin, Amanda D., Guschanski, Katerina, Schierup, Mikkel Heide, Beck, Robin M. D., Karakikes, Ioannis, Wang, Kevin C., Umapathy, Govindhaswamy, Roos, Christian, Boubli, Jean P., Siepel, Adam, Kundaje, Anshul, Paten, Benedict, Lindblad-Toh, Kerstin, Rogers, Jeffrey, Marqués-Bonet, Tomàs, and Farh, Kyle Kai-How
- Abstract
Noncoding DNA is central to our understanding of human gene regulation and complex diseases1,2, and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in the human genome3,4,5,6,7,8,9. Identifying the genomic elements that have become constrained specifically in primates has been hampered by the faster evolution of noncoding DNA compared to protein-coding DNA10, the relatively short timescales separating primate species11, and the previously limited availability of whole-genome sequences12. Here we construct a whole-genome alignment of 239 species, representing nearly half of all extant species in the primate order. Using this resource, we identified human regulatory elements that are under selective constraint across primates and other mammals at a 5% false discovery rate. We detected 111,318 DNase I hypersensitivity sites and 267,410 transcription factor binding sites that are constrained specifically in primates but not across other placental mammals and validate their cis-regulatory effects on gene expression. These regulatory elements are enriched for human genetic variants that affect gene expression and complex traits and diseases. Our results highlight the important role of recent evolution in regulatory sequence elements differentiating primates, including humans, from other placental mammals.
- Published
- 2024
4. Geographic patterns of tree dispersal modes in Amazonia and their ecological correlates
- Author
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Colciencias (Colombia), Universidad de Los Andes (Colombia), Amazonian Scientific Research Institute SINCHI, Fundação de Amparo à Pesquisa do Estado do Amazonas, University of Edinburgh, University of Queensland, Correa, Diego F., Stevenson, Pablo R., Umaña, María Natalia, de Souza Coelho, Luiz, de Andrade Lima Filho, Diógenes, Salomao, Rafael P., do Amaral, Iêda Leao, Colciencias (Colombia), Universidad de Los Andes (Colombia), Amazonian Scientific Research Institute SINCHI, Fundação de Amparo à Pesquisa do Estado do Amazonas, University of Edinburgh, University of Queensland, Correa, Diego F., Stevenson, Pablo R., Umaña, María Natalia, de Souza Coelho, Luiz, de Andrade Lima Filho, Diógenes, Salomao, Rafael P., and do Amaral, Iêda Leao
- Abstract
Aim: To investigate the geographic patterns and ecological correlates in the geographic distribution of the most common tree dispersal modes in Amazonia (endozoochory, synzoochory, anemochory and hydrochory). We examined if the proportional abundance of these dispersal modes could be explained by the availability of dispersal agents (disperser-availability hypothesis) and/or the availability of resources for constructing zoochorous fruits (resource-availability hypothesis). Time period: Tree-inventory plots established between 1934 and 2019. Major taxa studied: Trees with a diameter at breast height (DBH) ≥ 9.55 cm. Location: Amazonia, here defined as the lowland rain forests of the Amazon River basin and the Guiana Shield. Methods: We assigned dispersal modes to a total of 5433 species and morphospecies within 1877 tree-inventory plots across terra-firme, seasonally flooded, and permanently flooded forests. We investigated geographic patterns in the proportional abundance of dispersal modes. We performed an abundance-weighted mean pairwise distance (MPD) test and fit generalized linear models (GLMs) to explain the geographic distribution of dispersal modes. Results: Anemochory was significantly, positively associated with mean annual wind speed, and hydrochory was significantly higher in flooded forests. Dispersal modes did not consistently show significant associations with the availability of resources for constructing zoochorous fruits. A lower dissimilarity in dispersal modes, resulting from a higher dominance of endozoochory, occurred in terra-firme forests (excluding podzols) compared to flooded forests. Main conclusions: The disperser-availability hypothesis was well supported for abiotic dispersal modes (anemochory and hydrochory). The availability of resources for constructing zoochorous fruits seems an unlikely explanation for the distribution of dispersal modes in Amazonia. The association between frugivores and the proportional abundance of zoochory req
- Published
- 2023
5. The landscape of tolerated genetic variation in humans and primates
- Author
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EMBO, National Institutes of Health (US), Fundación la Caixa, Vienna Science and Technology Fund, European Commission, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), International Primatological Society, Rufford Foundation, Margot Marsh Biodiversity Foundation, Primate Conservation, Mamirauá Institute for Sustainable Development, Gordon and Betty Moore Foundation, Fundação de Amparo à Pesquisa do Estado do Amazonas, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), German Research Foundation, National Science Foundation (US), Ministry of Science and Technology of Vietnam, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Natural Sciences and Engineering Research Council of Canada, Canada Research Chairs, Illumina, Natural Environment Research Council (UK), San Diego Zoo Wildlife Alliance, Wenner-Gren Foundation, Leakey Foundation, National Geographic Society, National Institute on Aging (US), National Research Foundation Singapore, Swedish Research Council, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Juan, David [0000-0003-1912-9667], Valenzuela, Alejandro [0000-0001-6120-6246], Lizano, Esther [0000-0003-3304-9807], Navarro, Arcadi [0000-0003-2162-8246], Marqués-Bonet, Tomàs [0000-0002-5597-3075], Gao, Hong, Hamp, Tobias, Ede, Jeffrey, Schraiber, Joshua G., McRae, Jeremy, Singer-Berk, Moriel, Yang, Yanshen, Dietrich, Anastasia S. D., Fiziev, Petko P., Kuderna, Lukas F. K., Sundaram, Laksshman, Wu, Yibing, Adhikari, Aashish, Field, Yair, Chen, Chen, Batzoglou, Serafim, Aguet, Francois, Lemire, Gabrielle, Reimers, Rebecca, Balick, Daniel, Janiak, Mareike C., Kuhlwilm, Martin, Orkin, Joseph D., Manu, Shivakumara, Valenzuela, Alejandro, Bergman, Juraj, Rousselle, Marjolaine, Silva, Felipe Ennes, Agueda, Lidia, Blanc, Julie, Gut, Marta, Vries, Dorien de, Goodhead, Ian, Harris, R. Alan, Raveendran, Muthuswamy, Jensen, Axel, Chuma, Idriss S., Horvath, Julie E., Hvilsom, Christina, Juan, David, Frandsen, Peter, Melo, Fabiano R. de, Bertuol, Fabrício, Byrne, Hazel, Sampaio, Iracilda, Farias, Izeni, Amaral, João Valsecchi do, Messias, Mariluce, Silva, Maria N. F. da, Trivedi, Mihir, Rossi, Rogerio, Hrbek, Tomas, Andriaholinirina, Nicole, Rabarivola, Clément J., Zaramody, Alphonse, Jolly, Clifford J., Phillips-Conroy, Jane, Wilkerson, Gregory, Abee, Christian, Simmons, Joe H., Fernandez-Duque, Eduardo, Kanthaswamy, Sree, Shiferaw, Fekadu, Wu, Dongdong, Zhou, Long, Shao, Yong, Zhang, Guojie, Keyyu, Julius D., Knauf, Sascha, Le, Minh D., Lizano, Esther, Merker, Stefan, Navarro, Arcadi, Bataillon, Thomas, Nadler, Tilo, Khor, Chiea Chuen, Lee, Jessica, Tan, Patrick, Lim, Weng Khong, Kitchener, Andrew C., Zinner, Dietmar, Gut, Ivo, Melin, Amanda, Guschanski, Katerina, Schierup, Mikkel Heide, Beck, Robin M. D., Umapathy, Govindhaswamy, Roos, Christian, Boubli, Jean P., Lek, Monkol, Sunyaev, Shamil, O’Donnell-Luria, Anne, Rehm, Heidi L., Xu, Jinbo, Rogers, Jeffrey, Marqués-Bonet, Tomàs, Farh, Kyle Kai-How, EMBO, National Institutes of Health (US), Fundación la Caixa, Vienna Science and Technology Fund, European Commission, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), International Primatological Society, Rufford Foundation, Margot Marsh Biodiversity Foundation, Primate Conservation, Mamirauá Institute for Sustainable Development, Gordon and Betty Moore Foundation, Fundação de Amparo à Pesquisa do Estado do Amazonas, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), German Research Foundation, National Science Foundation (US), Ministry of Science and Technology of Vietnam, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Natural Sciences and Engineering Research Council of Canada, Canada Research Chairs, Illumina, Natural Environment Research Council (UK), San Diego Zoo Wildlife Alliance, Wenner-Gren Foundation, Leakey Foundation, National Geographic Society, National Institute on Aging (US), National Research Foundation Singapore, Swedish Research Council, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Juan, David [0000-0003-1912-9667], Valenzuela, Alejandro [0000-0001-6120-6246], Lizano, Esther [0000-0003-3304-9807], Navarro, Arcadi [0000-0003-2162-8246], Marqués-Bonet, Tomàs [0000-0002-5597-3075], Gao, Hong, Hamp, Tobias, Ede, Jeffrey, Schraiber, Joshua G., McRae, Jeremy, Singer-Berk, Moriel, Yang, Yanshen, Dietrich, Anastasia S. D., Fiziev, Petko P., Kuderna, Lukas F. K., Sundaram, Laksshman, Wu, Yibing, Adhikari, Aashish, Field, Yair, Chen, Chen, Batzoglou, Serafim, Aguet, Francois, Lemire, Gabrielle, Reimers, Rebecca, Balick, Daniel, Janiak, Mareike C., Kuhlwilm, Martin, Orkin, Joseph D., Manu, Shivakumara, Valenzuela, Alejandro, Bergman, Juraj, Rousselle, Marjolaine, Silva, Felipe Ennes, Agueda, Lidia, Blanc, Julie, Gut, Marta, Vries, Dorien de, Goodhead, Ian, Harris, R. Alan, Raveendran, Muthuswamy, Jensen, Axel, Chuma, Idriss S., Horvath, Julie E., Hvilsom, Christina, Juan, David, Frandsen, Peter, Melo, Fabiano R. de, Bertuol, Fabrício, Byrne, Hazel, Sampaio, Iracilda, Farias, Izeni, Amaral, João Valsecchi do, Messias, Mariluce, Silva, Maria N. F. da, Trivedi, Mihir, Rossi, Rogerio, Hrbek, Tomas, Andriaholinirina, Nicole, Rabarivola, Clément J., Zaramody, Alphonse, Jolly, Clifford J., Phillips-Conroy, Jane, Wilkerson, Gregory, Abee, Christian, Simmons, Joe H., Fernandez-Duque, Eduardo, Kanthaswamy, Sree, Shiferaw, Fekadu, Wu, Dongdong, Zhou, Long, Shao, Yong, Zhang, Guojie, Keyyu, Julius D., Knauf, Sascha, Le, Minh D., Lizano, Esther, Merker, Stefan, Navarro, Arcadi, Bataillon, Thomas, Nadler, Tilo, Khor, Chiea Chuen, Lee, Jessica, Tan, Patrick, Lim, Weng Khong, Kitchener, Andrew C., Zinner, Dietmar, Gut, Ivo, Melin, Amanda, Guschanski, Katerina, Schierup, Mikkel Heide, Beck, Robin M. D., Umapathy, Govindhaswamy, Roos, Christian, Boubli, Jean P., Lek, Monkol, Sunyaev, Shamil, O’Donnell-Luria, Anne, Rehm, Heidi L., Xu, Jinbo, Rogers, Jeffrey, Marqués-Bonet, Tomàs, and Farh, Kyle Kai-How
- Abstract
[INTRODUCTION] Millions of people have received genome and exome sequencing to date, a collective effort that has illuminated for the first time the vast catalog of small genetic differences that distinguish us as individuals within our species. However, the effects of most of these genetic variants remain unknown, limiting their clinical utility and actionability. New approaches that can accurately discern disease-causing from benign mutations and interpret genetic variants on a genome-wide scale would constitute a meaningful initial step towards realizing the potential of personalized genomic medicine., [RATIONALE] As a result of the short evolutionary distance between humans and nonhuman primates, our proteins share near-perfect amino acid sequence identity. Hence, the effects of a protein-altering mutation found in one species are likely to be concordant in the other species. By systematically cataloging common variants of nonhuman primates, we aimed to annotate these variants as being unlikely to cause human disease as they are tolerated by natural selection in a closely related species. Once collected, the resulting resource may be applied to infer the effects of unobserved variants across the genome using machine learning., [RESULTS] Following the strategy outlined above we obtained whole-genome sequencing data for 809 individuals from 233 primate species and cataloged 4.3 million common missense variants. We confirmed that human missense variants seen in at least one nonhuman primate species were annotated as benign in the ClinVar clinical variant database in 99% of cases. By contrast, common variants from mammals and vertebrates outside the primate lineage were substantially less likely to be benign in the ClinVar database (71 to 87% benign), restricting this strategy to nonhuman primates. Overall, we reclassified more than 4 million human missense variants of previously unknown consequence as likely benign, resulting in a greater than 50-fold increase in the number of annotated missense variants compared to existing clinical databases. To infer the pathogenicity of the remaining missense variants in the human genome, we constructed PrimateAI-3D, a semisupervised 3D-convolutional neural network that operates on voxelized protein structures. We trained PrimateAI-3D to separate common primate variants from matched control variants in 3D space as a semisupervised learning task. We evaluated the trained PrimateAI-3D model alongside 15 other published machine learning methods on their ability to distinguish between benign and pathogenic variants in six different clinical benchmarks and demonstrated that PrimateAI-3D outperformed all other classifiers in each of the tasks., [CONCLUSION] Our study addresses one of the key challenges in the variant interpretation field, namely, the lack of sufficient labeled data to effectively train large machine learning models. By generating the most comprehensive primate sequencing dataset to date and pairing this resource with a deep learning architecture that leverages 3D protein structures, we were able to achieve meaningful improvements in variant effect prediction across multiple clinical benchmarks.
- Published
- 2023
6. A global catalog of whole-genome diversity from 233 primate species
- Author
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Fundación la Caixa, Vienna Science and Technology Fund, European Commission, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), International Primatological Society, Rufford Foundation, Margot Marsh Biodiversity Foundation, Primate Conservation, Fundação de Amparo à Pesquisa do Estado do Amazonas, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), German Research Foundation, National Science Foundation (US), Ministry of Science and Technology of Vietnam, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Generalitat de Catalunya, Natural Sciences and Engineering Research Council of Canada, Canada Research Chairs, European Research Council, Natural Environment Research Council (UK), UK Research and Innovation, Department of Biotechnology (India), San Diego Zoo Wildlife Alliance, Wenner-Gren Foundation, Leakey Foundation, National Geographic Society, National Institute on Aging (US), National Institutes of Health (US), Swedish Research Council, National Research Foundation Singapore, Government of Singapore, Kuderna, Lukas F. K. [0000-0002-9992-9295], Kuhlwilm, Martin [0000-0002-0115-1797], Orkin, Joseph D. [0000-0001-6922-2072], Valenzuela, Alejandro [0000-0001-6120-6246], Juan, David [0000-0003-1912-9667], Lizano, Esther [0000-0003-3304-9807], Navarro, Arcadi [0000-0003-2162-8246], Marqués-Bonet, Tomàs [0000-0002-5597-3075], Kuderna, Lukas F. K., Gao, Hong, Janiak, Mareike C., Kuhlwilm, Martin, Orkin, Joseph D., Bataillon, Thomas, Manu, Shivakumara, Valenzuela, Alejandro, Bergman, Juraj, Rousselle, Marjolaine, Silva, Felipe Ennes, Agueda, Lidia, Blanc, Julie, Gut, Marta, Vries, Dorien de, Goodhead, Ian, Harris, R. Alan, Raveendran, Muthuswamy, Jensen, Axel, Chuma, Idrissa S., Horvath, Julie E., Hvilsom, Christina, Juan, David, Frandsen, Peter, Schraiber, Joshua G., Melo, Fabiano R. de, Bertuol, Fabrício, Byrne, Hazel, Sampaio, Iracilda, Farias, Izeni, Valsecchi, João, Messias, Malu, Silva, Maria N. F. da, Trivedi, Mihir, Rossi, Rogerio, Hrbek, Tomas, Andriaholinirina, Nicole, Rabarivola, Clément J., Zaramody, Alphonse, Jolly, Clifford J., Phillips-Conroy, Jane, Wilkerson, Gregory, Abee, Christian, Simmons, Joe H., Fernandez-Duque, Eduardo, Kanthaswamy, Sree, Shiferaw, Fekadu, Wu, Dongdong, Zhou, Long, Shao, Yong, Zhang, Guojie, Keyyu, Julius D., Knauf, Sascha, Le, Minh D., Lizano, Esther, Merker, Stefan, Navarro, Arcadi, Nadler, Tilo, Khor, Chiea Chuen, Lee, Jessica, Tan, Patrick, Lim, Weng Khong, Kitchener, Andrew C., Zinner, Dietmar, Gut, Ivo, Melin, Amanda D., Guschanski, Katerina, Schierup, Mikkel Heide, Beck, Robin M. D., Umapathy, Govindhaswamy, Roos, Christian, Boubli, Jean P., Rogers, Jeffrey, Farh, Kyle Kai-How, Marqués-Bonet, Tomàs, Fundación la Caixa, Vienna Science and Technology Fund, European Commission, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), International Primatological Society, Rufford Foundation, Margot Marsh Biodiversity Foundation, Primate Conservation, Fundação de Amparo à Pesquisa do Estado do Amazonas, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), German Research Foundation, National Science Foundation (US), Ministry of Science and Technology of Vietnam, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Generalitat de Catalunya, Natural Sciences and Engineering Research Council of Canada, Canada Research Chairs, European Research Council, Natural Environment Research Council (UK), UK Research and Innovation, Department of Biotechnology (India), San Diego Zoo Wildlife Alliance, Wenner-Gren Foundation, Leakey Foundation, National Geographic Society, National Institute on Aging (US), National Institutes of Health (US), Swedish Research Council, National Research Foundation Singapore, Government of Singapore, Kuderna, Lukas F. K. [0000-0002-9992-9295], Kuhlwilm, Martin [0000-0002-0115-1797], Orkin, Joseph D. [0000-0001-6922-2072], Valenzuela, Alejandro [0000-0001-6120-6246], Juan, David [0000-0003-1912-9667], Lizano, Esther [0000-0003-3304-9807], Navarro, Arcadi [0000-0003-2162-8246], Marqués-Bonet, Tomàs [0000-0002-5597-3075], Kuderna, Lukas F. K., Gao, Hong, Janiak, Mareike C., Kuhlwilm, Martin, Orkin, Joseph D., Bataillon, Thomas, Manu, Shivakumara, Valenzuela, Alejandro, Bergman, Juraj, Rousselle, Marjolaine, Silva, Felipe Ennes, Agueda, Lidia, Blanc, Julie, Gut, Marta, Vries, Dorien de, Goodhead, Ian, Harris, R. Alan, Raveendran, Muthuswamy, Jensen, Axel, Chuma, Idrissa S., Horvath, Julie E., Hvilsom, Christina, Juan, David, Frandsen, Peter, Schraiber, Joshua G., Melo, Fabiano R. de, Bertuol, Fabrício, Byrne, Hazel, Sampaio, Iracilda, Farias, Izeni, Valsecchi, João, Messias, Malu, Silva, Maria N. F. da, Trivedi, Mihir, Rossi, Rogerio, Hrbek, Tomas, Andriaholinirina, Nicole, Rabarivola, Clément J., Zaramody, Alphonse, Jolly, Clifford J., Phillips-Conroy, Jane, Wilkerson, Gregory, Abee, Christian, Simmons, Joe H., Fernandez-Duque, Eduardo, Kanthaswamy, Sree, Shiferaw, Fekadu, Wu, Dongdong, Zhou, Long, Shao, Yong, Zhang, Guojie, Keyyu, Julius D., Knauf, Sascha, Le, Minh D., Lizano, Esther, Merker, Stefan, Navarro, Arcadi, Nadler, Tilo, Khor, Chiea Chuen, Lee, Jessica, Tan, Patrick, Lim, Weng Khong, Kitchener, Andrew C., Zinner, Dietmar, Gut, Ivo, Melin, Amanda D., Guschanski, Katerina, Schierup, Mikkel Heide, Beck, Robin M. D., Umapathy, Govindhaswamy, Roos, Christian, Boubli, Jean P., Rogers, Jeffrey, Farh, Kyle Kai-How, and Marqués-Bonet, Tomàs
- Abstract
The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact of genomic diversity on fundamental biological processes. Analysis of that diversity provides insight into long-standing questions in evolutionary and conservation biology and is urgent given severe threats these species are facing. Here, we present high-coverage whole-genome data from 233 primate species representing 86% of genera and all 16 families. This dataset was used, together with fossil calibration, to create a nuclear DNA phylogeny and to reassess evolutionary divergence times among primate clades. We found within-species genetic diversity across families and geographic regions to be associated with climate and sociality, but not with extinction risk. Furthermore, mutation rates differ across species, potentially influenced by effective population sizes. Lastly, we identified extensive recurrence of missense mutations previously thought to be human specific. This study will open a wide range of research avenues for future primate genomic research.
- Published
- 2023
7. Fluoride exposure duringintrauterine and lactation periods promotes changes in the offspring rats' alveolar bone
- Author
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fundação de Amparo à Pesquisa do Estado do Amazonas, Martins Ferreira, Maria Karolina, Souza-Monteiro, Deiweson, Oliveira Bittencourt, Leonardo, Matos-Sousa, José Mário, Santos Chemelo, Victória, Neves Santos, Vinicius Ruan, Oliveira Nunes, Paula Beatriz, Souza Balbinot, Gabriela de, Ferraz Prado, Alejandro, Mezzomo Collares, Fabricio, Ager, F. J., Ortega-Feliú, I., Respaldiza, M. A., Pessanha, Sofia, Rodrigues Lima, Rafael, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fundação de Amparo à Pesquisa do Estado do Amazonas, Martins Ferreira, Maria Karolina, Souza-Monteiro, Deiweson, Oliveira Bittencourt, Leonardo, Matos-Sousa, José Mário, Santos Chemelo, Victória, Neves Santos, Vinicius Ruan, Oliveira Nunes, Paula Beatriz, Souza Balbinot, Gabriela de, Ferraz Prado, Alejandro, Mezzomo Collares, Fabricio, Ager, F. J., Ortega-Feliú, I., Respaldiza, M. A., Pessanha, Sofia, and Rodrigues Lima, Rafael
- Abstract
The importance of fluoride (F) for oral health is well established in the literature. However, evidence suggests that excessive exposure to this mineral is associated with adverse effects at different life stages and may affect many biological systems, especially mineralized tissues. The purpose of this study was to investigate the effects of F exposure during pregnancy and breastfeeding on the alveolar bone of the offspring since the alveolar bone is one of the supporting components of the dental elements. For this, the progeny rats were divided into three groups: control, 10 mg F/L, and 50 mg F/L for 42 (gestational and lactation periods). Analysis of the quantification of F levels in the alveolar bone by particle-induced gamma emission; Raman spectroscopy to investigate the physicochemical aspects and mineral components; computed microtomography to evaluate the alveolar bone microstructure and analyses were performed to evaluate osteocyte density and collagen quantification using polarized light microscopy. The results showed an increase in F levels in the alveolar bone, promoted changes in the chemical components in the bone of the 50 mg F/L animals (p < 0.001), and had repercussions on the microstructure of the alveolar bone, evidenced in the 10 mg F/L and 50 mg F/L groups (p < 0.001). Furthermore, F was able to modulate the content of organic bone matrix, mainly collagen; thus, this damage possibly reduced the amount of bone tissue and consequently increased the root exposure area of the exposed groups in comparison to a control group (p < 0.001). Our findings reveal that Fcan modulate the physicochemical and microstructural dimensions and reduction of alveolar bone height, increasing the exposed root region of the offspring during the prenatal and postnatal period. These findings suggest that F can modulate alveolar bone mechanical strength and force dissipation functionality.
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- 2022
8. Passivation blocks for fault tolerant control of nonlinear systems
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Fundação de Amparo à Pesquisa do Estado do Amazonas, Bessa, Iury, Puig, Vicenç, Martínez Palhares, Reinaldo, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Fundação de Amparo à Pesquisa do Estado do Amazonas, Bessa, Iury, Puig, Vicenç, and Martínez Palhares, Reinaldo
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This paper describes a novel passivity/dissipativity based approach for fault tolerant control (FTC) of nonlinear systems by means of fault hiding, i.e., by inserting reconfiguration blocks (RBs) between the plant and controller to mitigate the fault effects. The proposed approach is used to design a new kind of RB, called passivation block (PB), which is generically employed for sensor and actuator faults and achieves simultaneously series, feedback and feedfoward passivation of the controller during a fault occurrence. Based on the dissipativity theory, new conditions are obtained to design a dynamic PB (DPB) which requires minimum information on the system model. In particular, the proposed DPB can be systematically obtained by combining the LMI-based conditions based on the knowledge about the passivity indices. Numerical simulations are carried out and indicate that the PBs are able to stabilize an example of a faulty nonlinear system.
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- 2021
9. Historical biogeography identifies a possible role of Miocene wetlands in the diversification of the Amazonian rocket frogs (Aromobatidae: Allobates)
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Agence Nationale de la Recherche (France), Fundação de Amparo à Pesquisa do Estado do Amazonas, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Ministry of Culture (Czech Republic), National Museum (Czech Republic), Research Foundation - Flanders, Universidad de Los Andes (Colombia), German Research Foundation, Réjaud, Alexandre, Rodrigues, Miguel T., Crawford, Andrew J., Castroviejo-Fisher, Santiago, Jaramillo, Andrés F., Chaparro, Juan C., Glaw, Frank, Gagliardi-Urrutia, Giussepe, Moravec, Jiří, De la Riva, Ignacio, Pérez, Pedro, Lima, Albertina P., Werneck, Fernanda P., Hrbek, Tomas, Ron, Santiago R., Ernst, Raffael, Kok, Philippe J.R., Driskell, Amy, Chave, Jérôme, Fouquet, Antoine, Agence Nationale de la Recherche (France), Fundação de Amparo à Pesquisa do Estado do Amazonas, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Ministry of Culture (Czech Republic), National Museum (Czech Republic), Research Foundation - Flanders, Universidad de Los Andes (Colombia), German Research Foundation, Réjaud, Alexandre, Rodrigues, Miguel T., Crawford, Andrew J., Castroviejo-Fisher, Santiago, Jaramillo, Andrés F., Chaparro, Juan C., Glaw, Frank, Gagliardi-Urrutia, Giussepe, Moravec, Jiří, De la Riva, Ignacio, Pérez, Pedro, Lima, Albertina P., Werneck, Fernanda P., Hrbek, Tomas, Ron, Santiago R., Ernst, Raffael, Kok, Philippe J.R., Driskell, Amy, Chave, Jérôme, and Fouquet, Antoine
- Abstract
Aim: We investigate the spatiotemporal context of the diversification of Allobates, a widespread genus of Amazonian frogs with high species diversity particularly in western Amazonia. We tested if that diversity originated in situ or through repeated dispersals from other Amazonian areas and if this diversification took place during or after the Pebas system, a vast lacustrine system occupying most western Amazonia between 23 and 10 million years ago (Mya). Location: Amazonia. Taxon: Allobates (Anura: Aromobatidae). Methods: We gathered a spatially and taxonomically extensive sampling of mitochondrial DNA sequences from 932 Allobates specimens to delimit Operational Taxonomic Units (OTUs). Complete mitogenomes of these OTUs were assembled to reconstruct a time-calibrated phylogeny used to infer the historical and spatial origin of the Amazonian Allobates lineages. Results: Phylogenetic analyses and ancestral area reconstruction suggested that most of the western Amazonian lineages resulted from in situ diversification and that these events occurred between the inferred origin of the genus (25 Mya) and 10 Mya, with a possible peak between 14 and 10 Mya. Dispersal among areas mostly occurred from western Amazonia towards the Brazilian and the Guiana Shields. Closely related Allobates OTUs display an allopatric pattern of distribution, matching interfluves delimited by modern Amazonian rivers. Main Conclusions: In western Amazonia, diversification of Allobates appears to have been simultaneous with the last stages of the Pebas system (14–10 Mya). Subsequently (within the last 10 Mya), modern Amazonian river courses shaped the distribution pattern of Allobates species and possibly promoted allopatric speciation.
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- 2020
10. Entropy based routing for mobile, low power and lossy wireless sensors networks
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Universitat Politècnica de València. Departamento de Informática de Sistemas y Computadores - Departament d'Informàtica de Sistemes i Computadors, Governo do Estado do Amazonas, Agencia Estatal de Investigación, Sidia Instituto de Ciência e Tecnologia, Fundação de Amparo à Pesquisa do Estado do Amazonas, Secretaria de Estado de Ciencia, Tecnologia e Inovacao Amazonas, Ministerio da Ciencia, Tecnologia, Inovacoes e Comunicacoes, Brasil, Coordenaçao de Aperfeiçoamento de Pessoal de Nível Superior, Brasil, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil, Carvalho, Celso, Mota, Edjair, Ferraz, Eric, Seixas, Paulo, Souza, Paulo, Tavares, Vitor, Lucena Filho, Walfredo, Ferreira, David, Manzoni, Pietro, Tavares De Araujo Cesariny Calafate, Carlos Miguel, Universitat Politècnica de València. Departamento de Informática de Sistemas y Computadores - Departament d'Informàtica de Sistemes i Computadors, Governo do Estado do Amazonas, Agencia Estatal de Investigación, Sidia Instituto de Ciência e Tecnologia, Fundação de Amparo à Pesquisa do Estado do Amazonas, Secretaria de Estado de Ciencia, Tecnologia e Inovacao Amazonas, Ministerio da Ciencia, Tecnologia, Inovacoes e Comunicacoes, Brasil, Coordenaçao de Aperfeiçoamento de Pessoal de Nível Superior, Brasil, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil, Carvalho, Celso, Mota, Edjair, Ferraz, Eric, Seixas, Paulo, Souza, Paulo, Tavares, Vitor, Lucena Filho, Walfredo, Ferreira, David, Manzoni, Pietro, and Tavares De Araujo Cesariny Calafate, Carlos Miguel
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[EN] Routing protocol for low-power and lossy networks is a routing solution specifically developed for wireless sensor networks, which does not quickly rebuild topology of mobile networks. In this article, we propose a mechanism based on mobility entropy and integrate it into the corona RPL (CoRPL) mechanism, which is an extension of the IPv6 routing protocol for low-power and lossy networks (RPL). We extensively evaluated our proposal with a simulator for Internet of Things and wireless sensor networks. The mobility entropy-based mechanism, called CoRPL+E, considers the displacement of nodes as a deciding factor to define the links through which nodes communicate. Simulation results show that the proposed mechanism, when compared to CoRPL mechanism, is effective in reducing packet loss and latency in simulated mobile routing protocol for low-power and lossy networks. From the simulation results, one can see that the CoRPL+E proposal mechanism provides a packet loss reduction rate of up to 50% and delays reduction by up to 25% when compared to CoRPL mechanism.
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- 2019
11. Individual variation in feather corticosterone levels and its influence on haemosporidian infection in a Neotropical bird
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fundação de Amparo à Pesquisa do Estado do Amazonas, Fundaçao Capes (Brasil), Bosholn, Mariane, Anciães, Marina, Gil, Diego, Weckstein, Jason D., Dispoto, Janice H., Fecchio, Alan, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fundação de Amparo à Pesquisa do Estado do Amazonas, Fundaçao Capes (Brasil), Bosholn, Mariane, Anciães, Marina, Gil, Diego, Weckstein, Jason D., Dispoto, Janice H., and Fecchio, Alan
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Corticosterone (CORT) is the main glucocorticoid hormone of amphibians, reptiles, birds and some mammals. This hormone may have evolved as an adaptive metabolic mechanism, in part because increased concentrations of CORT are essential for individuals to manage energy resources and thus cope with negative perturbations such as predation and storms. The benefits of CORT are offset by costs, because elevated levels can suppress inflammatory responses of individuals, making them more susceptible to parasites and pathogens. In this study, we investigated the relationships between feather CORT levels, infection status and diversity of haemosporidian parasites in the Blue-crowned Manakin Lepidothrix coronata, considering possible effects related to the sex and age of individuals. We predicted higher levels of feather CORT in infected individuals. We observed that feather CORT levels were similar among individuals of different sexes and ages. Although haemosporidian infection status did not vary among sexes, occurrence probability was higher among younger individuals, which may indicate that the less developed immune system of these individuals makes them more susceptible to avian malaria. Contrary to expectations, we found that feather CORT levels were not associated with the infection status and diversity of haemosporidian parasites. That haemosporidian occurrence probability does not increase with elevated feather CORT levels suggests that individuals are not immunosuppressed by elevated levels of this hormone, at least to the extent that feather CORT truly reflects individual differences in the level of this hormone.
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- 2019
12. Obtention of Li3xLa2/3−xTiO3 ceramics from amorphous nanopowders by spark plasma sintering
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Fundação de Amparo à Pesquisa do Estado do Amazonas, European Commission, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Leyet, Y., Guerrero, F., Anglada-Rivera, J., Martínez, I., Amorín, Harvey, Romaguera-Barcelay, Y., Poyato, Rosalía, Gallardo-López, Ángela, Fundação de Amparo à Pesquisa do Estado do Amazonas, European Commission, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Leyet, Y., Guerrero, F., Anglada-Rivera, J., Martínez, I., Amorín, Harvey, Romaguera-Barcelay, Y., Poyato, Rosalía, and Gallardo-López, Ángela
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In this work, LiLaTiO powder with nominal lithium content (x = 0.08) was synthesized by mechano synthesis method. Spark plasma sintering (SPS) was employed to prepare lithium lanthanum titanium oxide solid-state ceramic. The techniques of X-ray diffraction, high resolution scanning electron microscopy, and Raman spectroscopy were used to characterize the composition and microstructure of samples. The results showed that fine-grained ceramics with relative density of 95.5% were obtained by sintering the oxide powders at 1100°C for only 5 min.
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- 2016
13. Diversification of the Pristimantis conspicillatus group (Anura: Craugastoridae) within distinct neotropical areas throughout the Neogene
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Antoine Fouquet, Alexandre Réjaud, Miguel T. Rodrigues, Santiago R. Ron, Juan C. Chaparro, Mariela Osorno, Fernanda P. Werneck, Tomas Hrbek, Albertina P. Lima, Teresa Camacho-Badani, Andres F. Jaramillo-Martinez, Jérôme Chave, Evolution et Diversité Biologique (EDB), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), Pontificia Universidad Católica del Ecuador, Universidad Nacional de San Antonio Abad del Cusco (UNSAAC), Instituto Amazonico de Investigaciones Cientificas, Partenaires INRAE, Instituto Nacional de Pesquisas da Amazônia (INPA), Federal University of Amazonas, Museo de Historia Natural ‘‘Alcide d'Orbigny’’ [Cochabamba, Bolivia] (MHNC), Pontifical Catholic University of Rio Grande do Sul (PUC-RS), French/Brazilian GUYAMAZON program action (IRD, CNRS, CTG, CIRAD and Brazilian Fundação de Amparo à Pesquisa do Estado do Amazonas-FAPEAM 062.00962/2018), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / National Council for Scientific and Technological Development (CNPq #446935/2014-0), NSF-FAPESP Dimensions of Biodiversity Program [grant numbers: BIOTA 2013/50297-0, NSF-DEB 1343578], NASA, SENESCYT (Arca de Noé Initiative), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil (CAPES # 001) and Programa i-COOP (# COOPA20188) from Consejo Superior de Investigaciones Científicas (CSIC), Spain, L’Oréal-UNESCO For Women In Science Program, Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP grant numbers: 2003/10335-8, 2011/50146-6, Colombia expedient No. RCI0005-00-2018 - Autoridad Nacional de Licencias Ambientales (ANLA), ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), ANR-10-LABX-0041,TULIP,Towards a Unified theory of biotic Interactions: the roLe of environmental(2010), and ANR-11-INBS-0001,ANAEE-FR,ANAEE-Services(2011)
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mitogenomics ,Pebas ,species delimitation ,historical biogeography ,miocene ,[SDV]Life Sciences [q-bio] ,Plant Science ,Ecology, Evolution, Behavior and Systematics - Abstract
Supplemental material for this article can be accessed here: https://doi.org/10.1080/14772000.2022.2130464; International audience; Determining the relative importance of dispersal and vicariance events across neotropical regions is a major goal in biogeography. These events are thought to be related to important landscape changes, notably the transition of Amazonia toward its modern hydrological configuration ca. 10 million years ago. We investigated the spatio-temporal context of the diversification of one of the major lineages of Pristimantis, a widespread and large genus of direct-developing Neotropical frogs. We gathered a spatially and taxonomically extensive sampling of mitochondrial DNA sequences from 754 Pristimantis gr. conspicillatus specimens, which led to delimiting 75 Operational Taxonomic Units (OTUs). Complete mitogenomes of 35 of these OTUs were assembled and collated with two nuDNA loci to reconstruct a time-calibrated phylogeny. We identified five major clades that diverged around the Oligocene-Miocene transition and that are largely restricted to distinct Neotropical regions i.e. Western Amazonia (P. conspicillatus clade), the Brazilian Shield (P. fenestratus clade), the Atlantic Forest (P. ramagii clade), the Guiana Shield (P. vilarsi clade) and the northern Andes (P. nicefori clade). The majority of the diversification events within these clades occurred in-situ from the early Miocene onward. Yet, a few ancient dispersal/vicariance events are inferred to have occurred among trans-Andean forests, the Atlantic Forest, the Brazilian and the Guiana Shields, but almost none in the last 10 Ma. The radical landscape transformations during the Miocene caused by the Andean orogeny and hydrological barriers such as the Pebas System and the subsequent transcontinental configuration of the Amazon drainage is a likely explanation for the isolation of the different clades within the P. gr. conspicillatus.
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- 2022
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14. An Overview of the Management of Mansonellosis
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Thuy-Huong Ta-Tang, Sérgio Luiz Bessa Luz, James Lee Crainey, José M. Rubio, National Council for Scientific and Technological Development (Brasil), Fundação de Amparo à Pesquisa do Estado do Amazonas (Brasil), and Instituto de Salud Carlos III
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030231 tropical medicine ,Review ,Disease ,03 medical and health sciences ,0302 clinical medicine ,Environmental health ,parasitic diseases ,medicine ,Mansonella perstans ,030212 general & internal medicine ,Mansonellosis ,Disease burden ,Lymphatic filariasis ,General Environmental Science ,Mansonella streptocerca ,doxycycline ,biology ,business.industry ,General Engineering ,medicine.disease ,biology.organism_classification ,Mansonella ozzardi ,Doxycycline ,Neglected tropical diseases ,General Earth and Planetary Sciences ,business ,Wolbachia ,Malaria - Abstract
Mansonellosis is caused by three filarial parasite species from the genus Mansonella that commonly produce chronic human microfilaraemias: M. ozzardi, M. perstans and M. streptocerca. The disease is widespread in Africa, the Caribbean and South and Central America, and although it is typically asymptomatic it has been associated with mild pathologies including leg-chills, joint-pains, headaches, fevers, and corneal lesions. No robust mansonellosis disease burden estimates have yet been made and the impact the disease has on blood bank stocks and the monitoring of other filarial diseases is not thought to be of sufficient public health importance to justify dedicated disease management interventions. Mansonellosis´s Ceratopogonidae and Simuliidae vectors are not targeted by other control programmes and because of their small size and out-door biting habits are unlikely to be affected by interventions targeting other disease vectors like mosquitoes. The ivermectin and mebendazole-based mass drug administration (iMDA and mMDA) treatment regimens deployed by the WHO´s Elimination of Neglected Tropical Diseases (ESPEN) programme and its forerunners have, however, likely impacted significantly on the mansonellosis disease burden, principally by reducing the transmission of M. streptocerca in Africa. The increasingly popular plan of using iMDA to control malaria could also affect M. ozzardi parasite prevalence and transmission in Latin America in the future. However, a potentially far greater mansonellosis disease burden impact is likely to come from shortcourse curative anti-Wolbachia therapeutics, which are presently being developed for onchocerciasis and lymphatic filariasis treatment. Even if the WHO´s ESPEN programme does not choose to deploy these drugs in MDA interventions, they have the potential to dramatically increase the financial and logistical feasibility of effective mansonellosis management.There is, thus, now a fresh and urgent need to better characterise the disease burden and ecoepidemiology of mansonellosis so that effective management programmes can be designed, advocated for and implemented. We would like to express our special thanks to María Belén García Fernández for helping us to draw the life-cycle of Mansonella species. JLC and SLBL also gratefully acknowledge support from the Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM; 062.01282/2018 and 002.00200/2019). And JLC would like to acknowledge support he receives from a Conselho Nacional de Desenvolvimento Científica e Tecnológico (CNPq) productivity grant. THTT is funded by a Sara Borrell contract from the Instituto de Salud Carlos III. Sí
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- 2021
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15. ETNOMICOLOGIA NO SUDOESTE DA AMAZÔNIA: CONHECIMENTO E INFORMAÇÃO
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Felipe Sant'Anna Cavalcante, Anita Yris Garcia Mendoza, Osvanda Silva de Moura, Milton César Costa Campos, Janaína Paolucci Sales De Lima, and Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)
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General Earth and Planetary Sciences ,General Environmental Science - Abstract
A Micologia é o ramo da Ciência que visa estudar os fungos bem como suas características e a Etnomicologia estuda a relação e as interações no contexto biológico, econômico e social, os usos históricos e o conhecimento dos fungos por diferentes etnias, raças ou nacionalidades. Nesse sentido, a finalidade do presente estudo visa analisar a percepção dos moradores sobre fungos em diferentes bairros do município de Humaitá-AM. O trabalho foi conduzido a partir de entrevistas semiestruturadas, visando à obtenção de dados socioeconômicos e micológicos. Os bairros pesquisados foram: São Pedro, Nova Esperança, São Domingos Sávio e São Sebastião. Para a análise dos dados foi utilizado a metodologia de análise textual discursiva. Foram aplicados 47 questionários, onde verificou que o gênero feminino predominou (65,95%) quando comparado ao gênero masculino (34,05%). Além disso, observou-se que 70,21% dos entrevistados não tem conhecimento sobre a importância dos fungos. Porém, os mesmos afirmaram conhecer a importância do meio ambiente para os seres vivos. Portanto, nos bairros entrevistados nota-se um desconhecimento sobre fungos e sua importância para o meio ambiente
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- 2022
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16. O fantasma das fábricas chinesas: expatriados, trabalhadores e políticas do modelo chinês no Brasil
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Maciel Brito, Cleiton Ferreira, Moura Maciel, Jeanne Mariel Brito de, and Fundação de Amparo à Pesquisa do Estado do Amazonas - FAPEAM
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Globalização chinesa. Amazônia. Modelo chinês. Trabalhadores - Abstract
Este artigo analisa a expansão global da China com foco em suas fábricas instaladas no Polo Industrial da Zona Franca de Manaus (ZFM), espaço produtivo situado na Amazônia brasileira e um dos principais destinos dos investimentos chineses na América do Sul. Nesse sentido, entre os anos de 2013 e 2017, fizemos pesquisa de campo em quatro fábricas chinesas, entrevistando trabalhadores, chineses expatriados, líderes sindicais e gerentes. Como principal descoberta da investigação, mostramos a instauração de um modelo chinês de gestão e evidenciamos como isso impactou o trabalho no Brasil. As reações a esse processo foram intensas e o artigo aborda as principais insatisfações tanto de trabalhadores, quanto das lideranças sindicais locais.
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- 2022
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17. A AMAZÔNIA NO(S) DISCURSO(S) DOS BOIS-BUMBÁS DE PARINTINS
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Mileny Brandão, Claudiana Narzetti, and Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)
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Neste artigo, apresentam-se resultados parciais de pesquisa em andamento acerca do(s) discurso(s) dos Bois-Bumbás de Parintins, Garantido e Caprichoso, materializado(s) nas letras de suas toadas. Especificamente, faz-se análise discursiva de um recorte do corpus da pesquisa, que consiste em sequências discursivas (versos das toadas) nas quais são empregadas as palavras-chave “floresta” “natureza”, “mata”, “selva”, “Amazônia”. A questão geral é: a acentuada rivalidade entre os dois Bois-Bumbás correlaciona-se a relações de oposição e conflito também no discurso? A questão específica é: qual o discurso deles sobre a floresta? O referencial teórico é o da AD francesa derivada dos trabalhos de Michel Pêcheux. A metodologia da pesquisa é comparativa/contrastiva, seguindo trabalhos pioneiros em AD na França (1960-70). Os resultados indicam que os referidos Bois-Bumbás não apenas sustentam o mesmo discurso sobre a Amazônia, mas também discursivizam os mesmos objetos de discurso.
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- 2021
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18. PERCURSOS E DISPUTAS DE SENTIDOS E DISCURSIVIDADES NA AMAZÔNIA: A COMUNIDADE DO MACURANY (PARINTINS/AM)
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Luiz Carlos Martins de Souza, Almiro Lima da Silva, and Fundação de Amparo à Pesquisa do Estado do Amazonas - FAPEAM
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Neste texto elencamos alguns dos percursos e disputas de sentidos e de discursividades recorrentes na Amazônia, em relação e contraste com a vida da comunidade ribeirinha do Macurany (Parintins/Amazonas). Para isso, nos baseamos em algumas obras e interpretações sobre a história da região, sobre comunidades ribeirinhas e indígenas, de modo a avaliarmos e relacionarmos, pela perspectiva materialista de Análise de Discurso, tais interpretações à realidade dessa comunidade ribeirinha de origem indígena, em Parintins, cidade atravessada pelas contradições das formações sociais amazônidas. Assim, percebemos a recorrência das discursividades instaladas e convocadas com a colonização, o que nos indica que precisamos de mais obras artísticas, escolares, acadêmicas e jornalísticas para expormos e dirimirmos os problemas e os efeitos catastróficos da violência simbólica, moral, política, social, econômica e física, causados por essas discursividades.
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- 2021
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19. ANÁLISE DO RISCO DE INUNDAÇÃO NO IGARAPÉ DO MINDU EM MANAUS – AMAZONAS
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de Queiroz, Matheus Silveira, Alves, Neliane de Sousa, Batista, Selma Paula Maciel, and Fundação de Amparo à Pesquisa do Estado do Amazonas - FAPEAM
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Desastres ,Morfometria do Canal ,Riscos ,Inundação ,General Medicine - Abstract
O objetivo deste trabalho é analisar os principais fatores causadores de risco de inundação no igarapé do Mindu localizado área urbana da cidade de Manaus. Para isso foram realizados trabalhos de campo entre os anos de 2017 e 2019 e ao longo dos 18,2 km de extensão do igarapé foram analisados parâmetros morfométricos da bacia hidrográfica, dados de precipitação, cotas limnimétricas e fatores antrópicos. Os parâmetros morfométricos analisados indicam que os riscos à inundação são baixos na bacia do igarapé do Mindu e apenas a densidade de drenagem pode promover a ocorrência de inundações. Estas inundações estão associadas principalmente às alterações antrópicas e a ocupação do solo na bacia. Observa-se que entre os anos de 1992 e 2018 houve um aumento significativo do desflorestamento e da aglomeração urbana, ocasionando uma maior concentração urbana na alta bacia e maior concentração de vegetação na média bacia. As mudanças de engenharia no canal, principalmente retificações, e o processo de dragagem se mostram ineficientes para o controle de inundações. As inundações são mais propicias a acontecer nos meses de novembro a abril, período em que as maiores precipitações na bacia ocorrem e o igarapé está no seu processo de enchente.
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- 2020
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20. Os Casarões da Sete: entre edificações demolidas e cenários construídos no Centro Histórico de Manaus/AM (1998-2010)
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Fernandes, Flávia de Oliveira, Santos, Tatiana de Lima Pedrosa, Universidade do Estado do Amazonas, and Fundação de Amparo à Pesquisa do Estado do Amazonas
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Patrimônio Histórico Imóvel ,Casarões da Sete ,Políticas Patrimoniais ,Interdisciplinaridade ,Manaus ,Arqueologia ,Antropologia ,História ,Patrimônio - Abstract
Este artigo tem como objetivo analisar os discursos do patrimônio histórico imóvel de Manaus, através dos Casarões da Sete, um conjunto arquitetônico histórico, localizado na Avenida Sete de Setembro no bairro Centro da cidade de Manaus, restaurado no ano de 1998 pelo Estado do Amazonas, porém, entre os anos de 2008 e 2010 foi alvo de demolição ilegal, aprovado também pelo Estado, se caracterizando como ações contraditórias. Para isso, traçamos uma contextualização dos embates em torno dos bens culturais através da modificação no entorno dos imóveis e discutimos a questão jurídica frente à demolição. De cunho qualitativo, tendo como prerrogativas, o contexto, a interpretação e o olhar crítico, a pesquisa contou com um campo de abordagem interdisciplinar entre as áreas do conhecimento que tem como tema os estudos do patrimônio cultural e também com a corrente dos estudos culturais. Abstract: This article aims to analyze the discourses on the immovable historical heritage of Manaus, through the Casarões da Sete, an architectural complex, located on Avenida Sete de Setembro in the Centro district of the city of Manaus, restored in 1998 and demolished between the years 2008 and 2010, which are characterized as contradictory actions carried out by the State of Amazonas itself. Thus, we ask ourselves about which narratives guide the references and policies of heritage in the city of Manaus? We traced then, a contextualization of the conflicts around cultural assets through the modification of the surroundings of the properties and also discussed the legal issue towards the demolition. As a methodology, this case study is of a qualitative nature, having as prerogatives the context, interpretation and critical eye, counting on an interdisciplinary field of approach among the areas of knowledge that have as their theme the studies of cultural heritage
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- 2021
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21. Kelch13 mutations in Plasmodium falciparum and risk of spreading in Amazon basin countries
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Paola Marchesini, Maria-Paz Ade, Maylis Douine, Marcus V. G. Lacerda, Angel Manuel Alvarez, Luana Mathieu, Magda Magris, Yassamine Lazrek, Magalie Demar, Gisely Cardoso de Melo, Lise Musset, Prabhjot Singh, Wuelton Marcelo Monteiro, Horace Cox, Jean S F Alexandre, Laboratoire de Parasitologie [Cayenne, Guyane française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française] (CCOMS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Ecole Doctorale 587 : Diversités, santé et développement en Amazonie (ED 587), Université de Guyane (UG), Réseau International des Instituts Pasteur (RIIP), Pan American Health Organization [Washington] (PAHO), Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), Universidade do Estado do Amazonas (UEA), Servicio Autónomo Centro Amazónico de Investigación y Control de Enfermedades Tropicales 'Simón Bolívar' (SACAICET), Ministry of Public Health [Georgetown, Guyana], Ministry of Health [Brasília, Brazil], Pan American Health Organization [Georgetown, Guyana] (PAHO), Pan American Health Organization - Organización Panamericana de la Salud [Caracas, Venezuela] (PAHO - OPS), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Instituto Leônidas e Maria Deane - Fiocruz Amazônia [Manaus, Brésil] (ILMD), Fundação Oswaldo Cruz (FIOCRUZ), This work was supported by Global Malaria Program (World Health Organization), Communicable Diseases and Environmental Determinants of Health Department (Pan American Health Organization), Guyamazon 3 Program, French Ministry for Research, European Commission Grant (Regional Fund for Development, Synergie GY0012082), Santé Publique France as National Reference Centre for Malaria and Investissement d’Avenir grant managed by Agence Nationale de la Recherche [CEBA (ref. ANR-10-LABX-25–01)]. L.C.M. received funding support from the Centre National d’Etudes Spatiales (CNES). The Manaus team was funded by Fundação de Amparo à Pesquisa do Estado do Amazonas-FAPEAM (PAPAC 005/2019, Posgrad and Pró-Estado). W.M.M. and M.V.G.L. are research fellows from CNPq., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), Musset, Lise, Laboratoires d'excellence - CEnter of the study of Biodiversity in Amazonia - - CEBA2010 - ANR-10-LABX-0025 - LABX - VALID, CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)
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Veterinary medicine ,Drug Resistance ,Protozoan Proteins ,[SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Genotype ,Pharmacology (medical) ,Malaria, Falciparum ,Original Research ,Sanger sequencing ,0303 health sciences ,education.field_of_study ,Human migration ,3. Good health ,AcademicSubjects/MED00290 ,Infectious Diseases ,symbols ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] ,Brazil ,[SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Amazon basin ,Microbiology (medical) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Plasmodium falciparum ,030231 tropical medicine ,Population ,Biology ,Kelch Repeat ,Antimalarials ,03 medical and health sciences ,symbols.namesake ,[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] ,parasitic diseases ,Humans ,AcademicSubjects/MED00740 ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,education ,030304 developmental biology ,Pharmacology ,business.industry ,Artemisinin resistance ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,biology.organism_classification ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Mutation ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,AcademicSubjects/MED00230 ,business - Abstract
Background The first potential focus for artemisinin resistance in South America was recently confirmed with the presence of the C580Y mutation in the Plasmodium falciparum kelch 13 gene (pfk13) in Guyana. Objectives This study aimed to strengthen pfk13 monitoring in the Amazon basin countries, to compile the available data and to evaluate the risk of spreading of mutations. Methods Sanger sequencing was done on 862 samples collected between 1998 and 2019, and a global map of pfk13 genotypes available for this region was constructed. Then, the risk of spreading of mutations based on P. falciparum case importation between 2015 and 2018 within countries of the Amazon basin was evaluated. Results No additional pfk13 C580Y foci were identified. Few mutations (0.5%, 95% CI = 0.3%–0.8%) in the propeller domain were observed in the general parasite population of this region despite a high proportion of K189T mutations (49.1%, 95% CI = 46.2%–52.0%) in the non-propeller domain. Case information revealed two patterns of intense human migration: Venezuela, Guyana and the Roraima State in Brazil; and French Guiana, Suriname and the Amapá State in Brazil. Conclusions There are few pfk13 mutant foci, but a high risk of dispersion in the Amazon basin, mainly from the Guiana Shield, proportionate to mining activities. Therefore, access to prompt diagnosis and treatment, and continuous molecular monitoring is essential in these geographical areas.
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- 2021
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22. Fluoride exposure duringintrauterine and lactation periods promotes changes in the offspring rats' alveolar bone
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Maria Karolina Martins Ferreira, Deiweson Souza-Monteiro, Leonardo Oliveira Bittencourt, José Mário Matos-Sousa, Victória Santos Chemelo, Vinicius Ruan Neves Santos, Paula Beatriz Oliveira Nunes, Gabriela de Souza Balbinot, Alejandro Ferraz Prado, Fabricio Mezzomo Collares, Francisco José Ager, Inés Ortega-Feliu, Miguel Angel Respaldiza, Sofia Pessanha, Rafael Rodrigues Lima, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), and Fundação de Amparo à Pesquisa do Estado do Amazonas
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Minerals ,Environmental Engineering ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,General Medicine ,General Chemistry ,Pollution ,Bone and Bones ,Rats ,Fluorides ,Bone Density ,Pregnancy ,Animals ,Lactation ,Environmental Chemistry ,Female ,Collagen - Abstract
The importance of fluoride (F) for oral health is well established in the literature. However, evidence suggests that excessive exposure to this mineral is associated with adverse effects at different life stages and may affect many biological systems, especially mineralized tissues. The purpose of this study was to investigate the effects of F exposure during pregnancy and breastfeeding on the alveolar bone of the offspring since the alveolar bone is one of the supporting components of the dental elements. For this, the progeny rats were divided into three groups: control, 10 mg F/L, and 50 mg F/L for 42 (gestational and lactation periods). Analysis of the quantification of F levels in the alveolar bone by particle-induced gamma emission; Raman spectroscopy to investigate the physicochemical aspects and mineral components; computed microtomography to evaluate the alveolar bone microstructure and analyses were performed to evaluate osteocyte density and collagen quantification using polarized light microscopy. The results showed an increase in F levels in the alveolar bone, promoted changes in the chemical components in the bone of the 50 mg F/L animals (p < 0.001), and had repercussions on the microstructure of the alveolar bone, evidenced in the 10 mg F/L and 50 mg F/L groups (p < 0.001). Furthermore, F was able to modulate the content of organic bone matrix, mainly collagen; thus, this damage possibly reduced the amount of bone tissue and consequently increased the root exposure area of the exposed groups in comparison to a control group (p < 0.001). Our findings reveal that Fcan modulate the physicochemical and microstructural dimensions and reduction of alveolar bone height, increasing the exposed root region of the offspring during the prenatal and postnatal period. These findings suggest that F can modulate alveolar bone mechanical strength and force dissipation functionality., This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001. R.R.L is a researcher from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and received grant under number 312275/2021-8. Also this research was funded by PROCAD Amazônia – CAPES (23038.005350/2018–78).
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- 2022
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23. CINEMA, IDEOLOGIA E INCONSCIENTE: COLIN MACCABE, STEPHEN HEATH E A SCREEN THEORY, O ELO PERDIDO ENTRE A ANÁLISE DE DISCURSIVIDADES E A ANÁLISE FÍLMICA
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de Souza, Luiz Carlos Martins and Fundação de Amparo à Pesquisa do Estado do Amazonas
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Linguística Aplicada ,Análise de Discurso ,Estudos Cinematográficos ,Análise do discurso fílmico. Michel Pêcheux. Colin MacCabe. Stephen Heath. Screen Theory - Abstract
Abordagens do funcionamento da ideologia, da discursividade e da subjetividade foram desenvolvidas e convergiram nos estudos cinematográficos nos anos 1970, na França e na Grã-Bretanha. Tais desenvolvimentos e convergência sucederam com o engajamento político de intelectuais, a partir da influência de Louis Althusser e Jacques Lacan. Esta retrospectiva resgata uma das principais perspectivas na história dos Estudos Cinematográficos, a Screen Theory, através das ideias dos editores da Screen Magazine nos anos 1970, Colin MacCabe e Stephen Heath. Explicita-se nela a influência do filósofo francês Michel Pêcheux, até então ignorada no Brasil e na França, e as consequências de sua “posição-sujeito” nos debates sobre a Screen Theory. A crítica da relação entre o Outro em Lacan e o Sujeito Universal em Althusser, e seu desdobramento no conceito de “posição-sujeito” em Pêcheux, são contribuições fundamentais dessa experiência para a perspectiva brasileira dos estudos materialistas da discursividade.
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- 2021
24. Os povos Guarani e suas relações cotidianas: uma memória em construção
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de Alencar, Larissa Albuquerque, Avellar, Luciana de Castro Maeda, de Almeida, Marcelina das Graças, Fundação de Amparo à Pesquisa do Estado do Amazonas, and Fundação de Amparo à Pesquisa do Estado de Minas Gerais
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Povos Guarani ,Relações Cotidianas ,Memória ,Moradia ,Gênero ,Ciências Sociais Aplicadas ,Arquitetura e Urbanismo - Abstract
Os indígenas da etnia Guarani - considerados os povos mais antigos do Brasil; são detentores de uma grande riqueza cultural que vem sendo fragmentada devido aos diversos processos de transformação social a que têm sido submetidos. Diante desse cenário, entender como eram configuradas as primeiras moradias do território nacional é de suma importância não somente para o registro histórico e de memória dos povos indígenas, mas, também, para compreender aspectos que envolvem a relação do ser humano com o espaço habitado na contemporaneidade. Para este fim foi realizada uma pesquisa qualitativa com o foco na narrativa que descreveu, a partir de registros documentais e bibliográficos, os costumes e as relações que ocorrem no âmbito de suas habitações o que resultou em um breve registro das questões de origem da diversidade cultural com ênfase na abordagem comportamental sob a ótica da moradia e do papel da mulher dentro dessa sociedade.
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- 2021
25. Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts
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Rosado, Jason, White, Michael T., Longley, Rhea J., Lacerda, Marcus, Monteiro, Wuelton, Brewster, Jessica, Sattabongkot, Jetsumon, Guzman-Guzman, Mitchel, Llanos-Cuentas, Alejandro, Vinetz, Joseph M., Gamboa, Dionicia, Mueller, Ivo, Malaria : parasites et hôtes - Malaria : parasites and hosts, Institut Pasteur [Paris], Santé publique : épidémiologie & sciences de l'information biomédicale (ED 393), Sorbonne Université (SU), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Instituto Leônidas e Maria Deane - Fiocruz Amazônia [Manaus, Brésil] (ILMD), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), Mahidol University [Bangkok], Universidad Peruana Cayetano Heredia (UPCH), Yale University School of Medicine, This work was supported by National Health and Medical Research Council Australia grants 1092789, 1134989 and 1043345 to IM (https://www.nhmrc.gov.au/), the Global Health Innovative Technology Fund grant T2015-142 to IM (https://www.ghitfund.org/), National Institutes of Health-National Institute of Allergy and Infectious Diseases (NIH-NIAID) U19AI089681 to JMV (https://www.niaid.nih.gov). This work has been supported by FIND with funding from the Australian and British governments. The Brazilian team was partly funded by Fundação de Amparo à Pesquisa do Estado do Amazonas-FAPEAM (PAPAC 005/2019 and Pró-Estado). JR is supported by the Pasteur - Paris University (PPU) International PhD Program. RJL received the Page Betheras Award from WEHI to provide funding for technical support for this project during parental leave. RJL is supported by a NHMRC Early Career Investigator Fellowship (1173210). ML and WM are fellows of the Brazilian National Council for Scientific and Technological Development. MGG is supported by Training Grant 5D43TW007120 (https://www.fic.nih.gov)., Institut Pasteur [Paris] (IP), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), and Yale School of Medicine [New Haven, Connecticut] (YSM)
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Plasmodium ,Physiology ,RC955-962 ,serology ,immunogenicity ,Pathology and Laboratory Medicine ,Biochemistry ,Geographical locations ,Cohort Studies ,immunoglobulin G ,Medical Conditions ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Immune Physiology ,Arctic medicine. Tropical medicine ,Peru ,Medicine and Health Sciences ,Prevalence ,Longitudinal Studies ,Immune Response ,receiver operating characteristic ,Immune System Proteins ,seroprevalence ,Plasmodium vivax malaria ,Thailand ,Serology ,risk factor ,[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology ,Antibody response ,pregnancy ,Public aspects of medicine ,RA1-1270 ,purl.org/pe-repo/ocde/ford#3.03.06 [https] ,Brazil ,Research Article ,Asia ,Immunology ,prevalence ,Plasmodium falciparum ,dispersity ,antibody titer ,Article ,Antibodies ,Parasite Groups ,parasitic diseases ,Parasitic Diseases ,Malaria, Vivax ,Humans ,follow up ,Serologic Tests ,human ,quality control ,Antigens ,Ascaris lumbricoides ,CD4+ T lymphocyte ,questionnaire ,Biology and Life Sciences ,Proteins ,antibody response ,South America ,Tropical Diseases ,vaccination ,discriminant analysis ,major clinical study ,enzyme linked immunosorbent assay ,Malaria ,sensitivity and specificity ,Immunoglobulin G ,Antibody Formation ,Parasitology ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,People and places ,Plasmodium vivax ,Apicomplexa ,Biomarkers - Abstract
Background Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, but little is known about the other factors that affect antibody responses in naturally infected people from endemic settings. To address this question, we studied IgG responses to novel serological exposure markers (SEMs) of P. vivax in three settings with different transmission intensity. Methodology We validated a panel of 34 SEMs in a Peruvian cohort with up to three years’ longitudinal follow-up using a multiplex platform and compared results to data from cohorts in Thailand and Brazil. Linear regression models were used to characterize the association between antibody responses and age, the number of detected blood-stage infections during follow-up, and time since previous infection. Receiver Operating Characteristic (ROC) analysis was used to test the performance of SEMs to identify P. vivax infections in the previous 9 months. Principal findings Antibody titers were associated with age, the number of blood-stage infections, and time since previous P. vivax infection in all three study sites. The association between antibody titers and time since previous P. vivax infection was stronger in the low transmission settings of Thailand and Brazil compared to the higher transmission setting in Peru. Of the SEMs tested, antibody responses to RBP2b had the highest performance for classifying recent exposure in all sites, with area under the ROC curve (AUC) = 0.83 in Thailand, AUC = 0.79 in Brazil, and AUC = 0.68 in Peru. Conclusions In low transmission settings, P. vivax SEMs can accurately identify individuals with recent blood-stage infections. In higher transmission settings, the accuracy of this approach diminishes substantially. We recommend using P. vivax SEMs in low transmission settings pursuing malaria elimination, but they are likely to be less effective in high transmission settings focused on malaria control., Author summary Plasmodium vivax still poses a threat in many countries due to its ability to cause recurrent infections. Key to achieving the goal of malaria elimination is the ability to quickly detect and treat carriers of relapsing parasites. Failing to identify this transmission reservoir will hinder progress towards malaria elimination. Recently, novel serological markers of recent exposure to P. vivax (SEM) have been developed and validated in low transmission settings. It is still poorly understood what factors affect the antibody response to these markers when evaluated in contrasting endemic contexts. To determine the factors that influence the antibody response to SEM, we compared the antibody levels in three sites with different transmission intensity: Thailand (low), Brazil (moderate) and Peru (high). In this study, we found that transmission intensity plays a key role in the acquisition of the antibody repertoire to P. vivax. In highly endemic sites, it is likely that immunological memory resulting from a constant and sustained exposure will impact the performance of SEMs to detect individuals with recent exposure to P. vivax. In summary, SEMs that perform well in low transmission sites do not perform as well in high transmission regions.
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- 2021
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26. Passivation blocks for fault tolerant control of nonlinear systems
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Iury Bessa, Reinaldo M. Palhares, Vicenç Puig, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Fundação de Amparo à Pesquisa do Estado do Amazonas, Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, and Universitat Politècnica de Catalunya. SAC - Sistemes Avançats de Control
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0209 industrial biotechnology ,Informàtica::Automàtica i control [Àrees temàtiques de la UPC] ,Computer science ,Passivity ,02 engineering and technology ,Fault-tolerant computing ,Fault (power engineering) ,020901 industrial engineering & automation ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,Nonlinear control systems ,Electrical and Electronic Engineering ,Fault hiding ,Block (data storage) ,Automatic control ,Tolerància als errors (Informàtica) ,020208 electrical & electronic engineering ,Control reconfiguration ,Fault tolerance ,Passivity indices ,Dissipativity theory ,Control automàtic ,Nonlinear system ,Control and Systems Engineering ,Fault-tolerant systems ,Tolerància als errors (Enginyeria) ,Fault tolerance (Engineering) ,Actuator - Abstract
This paper describes a novel passivity/dissipativity based approach for fault tolerant control (FTC) of nonlinear systems by means of fault hiding, i.e., by inserting reconfiguration blocks (RBs) between the plant and controller to mitigate the fault effects. The proposed approach is used to design a new kind of RB, called passivation block (PB), which is generically employed for sensor and actuator faults and achieves simultaneously series, feedback and feedfoward passivation of the controller during a fault occurrence. Based on the dissipativity theory, new conditions are obtained to design a dynamic PB (DPB) which requires minimum information on the system model. In particular, the proposed DPB can be systematically obtained by combining the LMI-based conditions based on the knowledge about the passivity indices. Numerical simulations are carried out and indicate that the PBs are able to stabilize an example of a faulty nonlinear system., This work was supported in part by the Brazilian agencies CNPq, Brazil (Grant numbers: 307933/2018-0, 201370/2019-0), FAPEMIG, Brazil (Grant number: PPM-00053-17) and by the PROPG-CAPES/FAPEAM Scholarship Program (Grant number: 88887.217045/2018-00). The material in this paper was not presented at any conference. This paper was recommended for publication in revised form by Associate Editor Hernan Haimovich under the direction of Editor Sophie Tarbouriech
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- 2021
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27. Construção de materiais didáticos manipuláveis para o ensino de matemática para alunos cegos
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Santos, Wenderson Cardoso dos, Universidade do Estado do Amazonas, Costa, Lucélida de Fátima Maia da, and Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)
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Educação ,Educação Matematica ,Materiais didáticos manipuláveis. Ensino de matemática. Aluno cego - Abstract
Nesse artigo apresentamos resultados de uma pesquisa qualitativa descritiva realizada no âmbito do Programa de Iniciação Científica - PAIC desenvolvido na Universidade do Estado do Amazonas – UEA, com o intuito de construir materiais didáticos manipuláveis para o ensino de matemática para alunos cegos. Os resultados obtidos indicam que os materiais didáticos manipuláveis são potenciais recursos ao ensino de matemática e pode possibilitar ao aluno cego o desenvolvimento do raciocínio matemático ao estabelecer relações entre as informações registradas em sua estrutura cognitiva e as novas informações que estão lhes sendo apresentadas, no caso do aluno cego passa inevitavelmente pelas sensações táteis.
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- 2020
28. Design social e reuso de pallets: estratégias para adequação/projeção de mobiliário da Associação de Idosos do Coroado, Manaus (Amazonas)
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Silva, Geislayne Mendonça, Nascimento, Claudete Catanhede do, Chateaubriand, Annunziata Donadio, and Fundação de Amparo à Pesquisa do Estado do Amazonas – FAPEAM.
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Sustainable Design ,Pallets ,Social Design ,ASSIC ,Design Sustentável ,Design Social ,Design - Abstract
The Coroado’s Association of Senior Citizens (Portuguese acronym: ASSIC) in partnership with the Coroado’s Program/UFAM, Manaus (Amazonas, Brazil), have developed studies to adapt their facilities, among them the research for designing furniture solutions through the reuse of pallets and Social Design guidelines, presented in this article. These solutions proved to be easily manufactured and an alternative of income generation for local carpenters due to the low cost of execution, the value added to the final products and the acceptance of users. A Associação de Idosos do Coroado (ASSIC) em parceria com o Programa Coroado/UFAM, Manaus (Amazonas), têm desenvolvido estudos para adequação de sua sede, entre eles a pesquisa para geração de alternativas de mobiliário a partir do reuso de pallets e de diretrizes do Design Social, apresentadas neste artigo. Essas alternativas mostraram-se ser de fácil fabricação e uma alternativa de geração de renda para marceneiros locais pelo baixo custo de execução, pelo valor agregado aos produtos finais e pela aceitação dos usuários.
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- 2020
29. AS REPRESENTAÇÕES SOBRE A HISTÓRIA DA ÁFRICA, DOS AFRICANOS E DOS AFRODESCENDENTES NOS LIVROS DIDÁTICOS DE HISTÓRIA DO ENSINO FUNDAMENTAL DA ESCOLA ESTADUAL DOM GINO MALVESTIO NO MUNICÍPIO DE PARINTINS/AM (2017)
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Janderson Lopes Brito and Fundação de Amparo à Pesquisa do Estado do Amazonas – FAPEAM
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afrodescendentes ,História ,AFRICANINDADES E CULTURA AFRO-BRASILEIRA ,africano ,HISTÓRIA ,AFRICANO ,AFRODESCENDENTES ,história ,General Works - Abstract
THE REPRESENTATIONS ON THE HISTORY OF AFRICA, AFRICANS AND AFRODESCENDANTS IN THE DIDACTIC HISTORY BOOKS OF THE FUNDAMENTAL STUDY SCHOOL DOM GINO MALVESTIO IN THE PARINTINS / AM CITY (2017).Resumo: Esta pesquisa foi realizada com intuito de analisar a coleção de livros didáticosdo ensino fundamental da escola estadual Dom Gino Malvestio - Parintins/AM destinados ao triênio 2107/2018 e 2019 com objetivo de verificar a imagem construída sobre a História da África presente nas abordagens destes livros didáticos de história; verificar de que forma a cultura dos africanos e afrodescendentes são representadas neles e por fim observar se as representações sobre os africanos e afrodescendentes presentes nos citados livros didáticos, procuramos também responder algumas perguntas que nortearam nossas análise como por exemplo: será que as antigas abordagens História da África cultura dos africanos e afrodescendentes permanecem? Ou foram eliminadas depois da Lei 10.639/2003 que torna obrigatório o ensino de História e Cultura Afro-Brasileira? Uma historiografia que repensou a presença da História da África e dos africanos e afrodescendentes evidenciando principalmente o africano e o afrodescendente enquanto sujeitos históricos teria chegado nas páginas desse material? Depois de analisado nossas fontes e detectado alguns problemas foram sugeridas as devidas alternativas, possibilidades e novos caminhos a serem trilhados baseados nos resultados dapesquisa.Palavras chave: História, África, africanos, afrodescendentes, livro didático.Abstract: This research was carried out with the purpose of analyzing the collection of textbooks of elementary school of the state school Dom Gino Malvestio - Parintins / AM destined to the triennium 2107/2018 and 2019 with the purpose of verifying the constructed image on the History of Africa present in the approaches to these history textbooks; to verify how the culture of Africans and Afrodescendants are represented in them, and finally to see if the representations about Africans and Afrodescendents present in the mentioned textbooks, we also try to answer some questions that guided our analysis such as: do the old approaches History of African culture of Africans and Afrodescendants remain? Or were they eliminated after Law 10.639 / 2003, which makes the teaching of Afro-Brazilian History and Culture compulsory? A historiography that rethought the presence of the History of Africaand the Africans and Afrodescendents evidencing mainly the African and Afrodescendant as historical subjects would have arrived in the pages of this material? After analyzing our sources and detecting some problems we have suggested the appropriate alternatives, possibilities and new paths to be traced based on the results of theresearch.Keywords: History, Africa, African, Afro-descendant, textbook.Recebido em: 17/01/2018 – Aceito em 28/01/2018
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- 2018
30. DINAMICA DO USO DA TERRA NO MUNICIPIO DE IRANDUBA (2005-2015) E A RELAÇÃO COM OS EMPREENDIMENTOS IMOBILIÁRIOS
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Gomes, Suzana dos Santos, Wachholz, Flávio, Universidade do Estado do Amazonas, and Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)
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Região Metropolitana de Manaus ,solo exposto ,General Medicine ,agropecuária - Abstract
A pesquisa relacionou o uso da terra à instalação de empreendimentos imobiliários em Iranduba - AM. Os mapas de uso da terra foram elaborados para descrever dois momentos, 2006 e 2015. As imagens de satélite Landsat 5 TM de (16-07-2006) e do Landsat 8 de (11-09-2015). O processamento das imagens realizado no software Spring 5.4.3, gerou uma classificação, foram obtidas as classes: floresta, água preta, água branca, agropecuária e solo exposto. Em ambos os mapas as áreas de floresta são dominantes e localizam-se a noroeste do município, as áreas de agropecuária aparecem nas proximidades da cidade de Iranduba e da rodovia AM-070. A classe de água branca teve um aumento em 2015 (10,88 para 12,25%) em detrimento da redução das águas pretas (4,19 para 2,87%). O aumento de solo exposto (1,05 para 1,79%) e a diminuição da agropecuária (10,34 para 7,40%) está relacionado a substituição de áreas agrícolas por empreendimentos imobiliários. A área compreendida pelo empreendimento Bairro Planejado Nova Manaus em 2013, era utilizado em 2007 para agropecuária. O interesse imobiliário, sobre as áreas é devido à proximidade da Rodovia AM-070 e já estarem desmatadas. Por enquanto tem diversos empreendimentos imobiliários, transformando a paisagem local, que estão em fase de instalação e venda, mas na maioria em solo exposto.
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- 2018
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31. Origin of the interest, motivation and environmental concern in socio-environmentally engaged young in the Manaus-AM metropolitan region
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Damaris Teixeira Paz, Maria Inês Gasparetto Higuchi, Universidade Federal do Amazonas, Fundação de Amparo à Pesquisa do Estado do Amazonas, and Conselho Nacional de Desenvolvimento Científico e Tecnológico
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Ciências Ambientais ,Psicologia Ambiental ,Youth ,Socio-environmental Collectives ,Socio-Environmental Engagement ,coletivos socioambientais ,Gender studies ,engajamento social ,Coletivos Socioambientais ,Social insertion ,juventude e meio ambiente ,Management, Monitoring, Policy and Law ,Development ,Metropolitan area ,Juventude ,Engajamento Socioambiental ,Environmental sciences ,GE1-350 ,Sociology ,Qualitative research - Abstract
This research discusses aspects associated to the emergence of environmental interest in young people engaged in social and environmental collectives as well as the main motivations and concerns that led them to militancy of this nature. The qualitative research was carried out with 19 young people from six socio-environmental groups from three cities in the metropolitan region of Manaus-AM. The data obtained from semi-structured interviews indicated that the concerns about environmental problems of these young people are located mainly in broad areas. The contributions of family,teachers or friends and the coexistence with people already engaged in pro-environmental actions related to these problems, are pointed out as stimulators of interest and entry into social and environmental collectives. The initial interest in joining a group opens new avenues for learning and at the same time fulfills the youth's desire for greater social insertion., Esta pesquisa discute aspectos associados à origem do interesse ambiental em jovens engajados em coletivos socioambientais bem como as principais motivações e preocupações que os levaram à militância dessa natureza. A pesquisa de natureza qualitativa foi realizada com 19jovens integrantes de seis grupos socioambientais de três cidades da região metropolitana de Manaus-AM. Os dados obtidos a partir de entrevistas semiestruturadas indicaram que as preocupações sobre problemas ambientais desses jovens se situam principalmente em âmbitos abrangentes. As contribuições de familiares e de professores, de amigos e da convivência com pessoas já engajadas em ações pró-ambientais referentes a esses problemas são apontadas como ativadores do interesse e ingresso nos coletivos socioambientais. Verificou-se que o interesse inicial em se inserir em um grupo abre caminhos para novas aprendizagens e ao mesmo tempo em que atende aos anseios juvenis de maior inserção social e engajamento em ações pró-ambientais.
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- 2018
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32. Saúde e Desenvolvimento Humano: Revisão Integrativa da Literatura Sobre Psicologia do Desenvolvimento Humano e Odontopediatria
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Martins, Arã Saíd, Neves, André Luiz Machado das, and Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)
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Human Development ,Dentistry ,Kid ,Pediatric dentistry ,Psychology ,Developmental psychology ,Desenvolvimento Humano ,Odontologia ,Criança ,Odontopediatria ,Psicologia ,Psicologia do desenvolvimento ,Psicologia do desenvolvimento, saúde, odontologia - Abstract
The study of the interdisciplinary relationship between developmental psychology and pediatric dentistry in the literature can present the appropriate health conditions for the child. This article aims to identify, in national and international literature, scientific evidence on the implications of developmental psychology on health and pediatric dentistry. With a qualitative methodological approach acquiring contours of the historical-cultural perspective, with emphasis in the categories of meaning, an Integrative Literature Review (RIL) was realized. The data collected in 15 articles allowed the identification of three distinct categories that sought to express the meanings and the objective of the articles: Biopsychosocial variables in oral health conditions in childhood and the interdisciplinary approach; Dental care in the sociocultural perspective of human development; and harmful habits, child development and parental care. The present study concluded that developmental psychology has expanded beyond the traditional practice in education, psychoanalysis and studies of childhood and adolescence. When referring to its performance in dentistry, the contribution has extrapolated the traditional logic of control techniques. O estudo da relação interdisciplinar entre psicologia do desenvolvimento e odontopediatria existente na literatura, pode apresentar as condições de saúde adequadas à criança. Este artigo tem como objetivo identificar, na literatura nacional e internacional, as evidências científicas sobre as implicações da psicologia do desenvolvimento na saúde e na odontopediatria. Com uma abordagem metodológica qualitativa adquirindo contornos da perspectiva histórico-cultural, com ênfase nas categorias de significado, realizou-se uma Revisão Integrativa de Literatura (RIL). Os dados coletados em 15 artigos possibilitaram a identificação de três categorias distintas, que buscaram expressar os significados e o objetivo dos artigos: Variáveis biopsicossociais nas condições de saúde bucal na infância e a abordagem interdisciplinar; Atendimento em odontopediatria na perspectiva sociocultural do desenvolvimento humano; e Hábitos deletérios, desenvolvimento infantil e cuidado dos pais. O presente estudo concluiu que a psicologia do desenvolvimento expandiu-se para além da tradicional atuação na educação, psicanálise e estudos da infância e adolescência. Quando se refere a sua atuação na odontologia, a contribuição tem extrapolado a lógica tradicional de técnicas de controle.
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- 2020
33. Efetividade da Lei nº 12.732/2012 na assistência às neoplasias malignas e sua associação com a mortalidade no Estado do Amazonas
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Rodrigues, Alcinéia da Silva, Alencar, Leila Cristina Ferreira Silva de, Castelo Branco, Vitória Regina Maia, and Fundação de Amparo à Pesquisa do Estado do Amazonas - FAPEAM
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Direito ,Direitos Fundamentais ,Fundamental Law ,Law of 60 Days ,Malignant Neoplasms ,Direito Fundamental ,Lei dos Sessenta Dias ,Neoplasias Malignas - Abstract
This article presents the results of a research developed with the objective of analyzing the effectiveness of Law no. 12.732/2012, the law of 60 days, in the assistance of malignant neoplasms and its association with mortality in the state of Amazonas. For this purpose, it was chosen as specific objectives: to estimate the mean waiting time for diagnosis and treatment by a group of neoplasms; To present socio-demographic, epidemiological and clinical factors according to opportune/inopportune waiting time between diagnosis and treatment by groups of malignant neoplasms; and constitute a legal scenario related to the effectiveness of the law in accordance with sociodemographic, epidemiological and clinical factors. A mixed methodology was adopted to perform a descriptive study in sectional cut (2015-2016) of malignant neoplasms registered in residents of Amazonas. The results indicate the non-effectiveness of the Law of 60 days for patients affected by malignant neoplasms in the state of Amazonas, which compromises the efficacy of the treatment and influences public expenditures with disease assistance. Nesse artigo, apresentam-se resultados de uma pesquisa desenvolvida com o objetivo de analisar a efetividade da Lei 12. 732/2012, Lei dos 60 dias, na assistência às neoplasias malignas e sua associação com a mortalidade no Estado do Amazonas. Para tanto, elegeram-se como objetivos específicos: estimar o tempo médio de espera para o diagnóstico e tratamento por grupo de neoplasia; apresentar fatores sociodemográficos, epidemiológicos e clínicos segundo tempo de espera oportuno/inoportuno entre o diagnóstico e tratamento por grupos de neoplasias malignas; e constituir um cenário jurídico relacionado à efetividade da Lei de acordo com fatores sociodemográficos, epidemiológicos e clínicos. Adotou-se uma metodologia mista para a realização do estudo descritivo em corte seccional (2015-2016) de neoplasias malignas registradas em residentes no Amazonas. Os resultados indicam a não efetividade da Lei dos sessenta dias para os pacientes acometidos por neoplasias malignas no Estado do Amazonas, o que compromete a eficácia do tratamento e influencia os gastos públicos com auxílio doença.
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- 2020
34. Historical biogeography identifies a possible role of Miocene wetlands in the diversification of the Amazonian rocket frogs (Aromobatidae: Allobates)
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Philippe J. R. Kok, Jiří Moravec, Jérôme Chave, Andrés F. Jaramillo, Amy C. Driskell, Alexandre Réjaud, Fernanda P. Werneck, Antoine Fouquet, Tomas Hrbek, Andrew J. Crawford, Santiago R. Ron, Santiago Castroviejo-Fisher, Ignacio De la Riva, Frank Glaw, Miguel Trefaut Rodrigues, Giussepe Gagliardi-Urrutia, Pedro E. Pérez, Albertina P. Lima, Raffael Ernst, Juan C. Chaparro, Agence Nationale de la Recherche (France), Fundação de Amparo à Pesquisa do Estado do Amazonas, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Ministry of Culture (Czech Republic), National Museum (Czech Republic), Research Foundation - Flanders, Universidad de Los Andes (Colombia), German Research Foundation, Evolution et Diversité Biologique (EDB), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées
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0106 biological sciences ,Neotropics ,DNA-based species delimitation ,Amazonian ,Biogeography ,Allopatric speciation ,Context (language use) ,[SDV.BID]Life Sciences [q-bio]/Biodiversity ,010603 evolutionary biology ,01 natural sciences ,Historical biogeography ,03 medical and health sciences ,Aromobatidae ,Ecology, Evolution, Behavior and Systematics ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,Mitogenomics ,0303 health sciences ,Ecology ,biology ,Anuran ,15. Life on land ,biology.organism_classification ,Riverine barrier ,MIOCENO ,Taxon ,Geography ,Biological dispersal ,Allobates ,Neogene - Abstract
Aim: We investigate the spatiotemporal context of the diversification of Allobates, a widespread genus of Amazonian frogs with high species diversity particularly in western Amazonia. We tested if that diversity originated in situ or through repeated dispersals from other Amazonian areas and if this diversification took place during or after the Pebas system, a vast lacustrine system occupying most western Amazonia between 23 and 10 million years ago (Mya). Location: Amazonia. Taxon: Allobates (Anura: Aromobatidae). Methods: We gathered a spatially and taxonomically extensive sampling of mitochondrial DNA sequences from 932 Allobates specimens to delimit Operational Taxonomic Units (OTUs). Complete mitogenomes of these OTUs were assembled to reconstruct a time-calibrated phylogeny used to infer the historical and spatial origin of the Amazonian Allobates lineages. Results: Phylogenetic analyses and ancestral area reconstruction suggested that most of the western Amazonian lineages resulted from in situ diversification and that these events occurred between the inferred origin of the genus (25 Mya) and 10 Mya, with a possible peak between 14 and 10 Mya. Dispersal among areas mostly occurred from western Amazonia towards the Brazilian and the Guiana Shields. Closely related Allobates OTUs display an allopatric pattern of distribution, matching interfluves delimited by modern Amazonian rivers. Main Conclusions: In western Amazonia, diversification of Allobates appears to have been simultaneous with the last stages of the Pebas system (14–10 Mya). Subsequently (within the last 10 Mya), modern Amazonian river courses shaped the distribution pattern of Allobates species and possibly promoted allopatric speciation., This study benefited from an “Investissement d’Avenir” grant managed by the Agence Nationale de la Recherche (CEBA, ref. ANR-10-LABX-25-01; TULIP, ref. ANR-10-LABX-0041; ANAEE-France: ANR-11-INBS-0001). AF and FPW acknowledge the French/Brazilian GUYAMAZON program action (IRD, CNRS, CTG, CIRAD and Brazilian Fundação de Amparo à Pesquisa do Estado do Amazonas-FAPEAM 062.00962/2018) and co-coordinated by A. Fouquet and F. P. Werneck. MTR thanks Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP grant numbers: 2003/10335-8, 2011/50146-6 and NSF-FAPESP Dimensions of Biodiversity Program [grant numbers: BIOTA 2013/50297-0, NSF-DEB 1343578]) and NASA. SRR acknowledges a grant from SENESCYT (Arca de Noé Initiative). FPW thanks CNPq (Productivity Fellowship), FAPEAM, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-CAPES (Visiting Professor Fellowship) and the L’Oréal-UNESCO For Women In Science Program. AFJ is supported by the Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior-Brasil (CAPES Finance Code: 88882.462010/2019-01). JM is supported by the Ministry of Culture of the Czech Republic (DKRVO 2019-20023/6.VI.b, National Museum Prague, 00023272). PJRK was supported by research grants from the Fonds voor Wetenschappelijk Onderzoek (FWO12A7614N and FWO12A7617N). AJC was supported by Research Program INV-2017-51-1432 from the School of Sciences, Universidad de los Andes. RE was supported by research grants from the Deutsche Forschungsgemeinschaft (DFG ER 589/1-1 & ER 589/2-1).
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- 2020
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35. Aspectos de matrilateralidade em um sistema de nominação patrilinear: explorando formulações de gênero e pessoa entre os Tukano
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Fabiane Vinente dos Santos and Fundação de Amparo à Pesquisa do estado do Amazonas
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Matrilateral ,Amazon rainforest ,Kinship ,Ethnology ,General Medicine ,Sociology ,Clan - Abstract
O artigo aborda a nominação das crianças filhas de pai não indígena (pehkasã, nome pelo qual os não indígenas são chamados em Tukano) e mãe Tukano. Chamadas de moregi (misturadas), estas crianças, pelos princípios de nominação, não teriam direito a um dos nomes do estoque masculino (bahseke wame), uma vez que seus pais são pehkasã e nãopossuem vinculação clânica nem nome para lhes legar. Contudo, a nominação destas crianças é possibilitada por um arranjo familiar – o pai da mãe (FM) atua como nominador matrilateral. Meu objetivo é explorar as consequências deste arranjo matrilateral, imprevisto no parentesco Tukano, e utilizar tal “inovação” para discutir alguns pontos sobre as transformações na questão de gênero no noroeste amazônico. Somente tomando a sério as diferenças de enfoque nas perspectivas masculinas e femininas, seria possível explicar o arranjo.
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- 2019
36. Avaliação térmica, física e mecânica de blocos de concreto com poliestireno expandido reciclado
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Raimundo Pereira de Vasconcelos, Paulo Gonçalves, Fundação de Amparo à Pesquisa do Estado do Amazonas, Instituto de Pesquisas Tecnológicas de São Paulo, Universidade do Estado do Amazonas, and Companhia de Pesquisa de Recursos Minerais do Estado do Amazonas
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Concreto com EPS ,Materiais alternativos ,Termografia ,Geography, Planning and Development - Abstract
Resumo A presente pesquisa produziu blocos de concretos com substituição parcial do agregado graúdo comumente utilizado por poliestireno expandido reciclado. Para tanto, uma dosagem experimentalé proposta a partir da associação do modelo de empacotamento compressível com a metodologia adaptada de Tango, publicada em 1994, produzindo-se quatro tipos de blocos (um referencial sem substituição e três com substituição volumétrica de 5%, 10% e 15% do agregado pelo poliestireno expandido), com fator a/c igual a 0,5. As características físicas e mecânicas foram obtidas em conformidade com a NBR 12118:2013, identificando-se que os blocos referenciais e com 5% de substituição poderiam ser empregados para fins estruturais, enquanto aqueles com 10% e 15% de substituição não alcançaram a resistência mínima estabelecida pela NBR 6136:2016. A análise do desempenho térmico adotou procedimentos de cálculo da NBR 15220-2:2005, verificando-se os limites estabelecidos pela NBR 15575-4:2013. O conforto térmico proporcionado pelos blocos referenciais e com 15% de substituição, em protótipos de alvenaria, apresentaram resultados semelhantes para temperaturas internas durante o período observado. Contudo, no horário de pico da temperatura ambiente, verificaram-se maiores atrasos e inércia térmica na alvenaria com poliestireno reciclado.
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- 2019
37. Manejo florestal comunitário na Amazônia: comparação entre um modelo introduzido e a extração ilegal de madeira
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Edson José Vidal da Silva, Philippe Waldhoff, Fundação de Amparo à Pesquisa do Estado do Amazonas (Programa de Bolsas), and e Conselho Nacional de Desenvolvimento Científico e Tecnológico (Processo no. 462492/2014-1)
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Extração de madeira ,Amazônia ,Meios de vida ,Licenciamento ambiental - Abstract
A extração de pequenas quantidades de madeira faz parte dos meios de vida de diversas comunidades tradicionais na Amazônia. A exigência da licença ambiental trouxe enormes desafios para seus protagonistas, colocando muitos em uma situação de clandestinidade. Foi comparada a situação entre extratores que adotaram as regras formais do plano de manejo florestal e os que permaneceram extraindo de forma convencional. Foram realizadas entrevistas e análise documental. Os dados foram analisados utilizando-se a base conceitual dos meios de vida sustentáveis, estatística descritiva e testes de análise de variâncias. A extração de madeira com plano de manejo florestal apresentou melhores resultados em relação ao capital natural e piores em relação ao capital financeiro e físico. Concluiu-se que a adoção das regras do manejo florestal sustentável contribui para a conservação da floresta e das espécies manejadas, mas levaram à irregularidade da renda e a dependência financeira de agentes externos.
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- 2019
38. Fábricas selvagens: transformações do trabalho no Polo Industrial da Zona Franca de Manaus
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Cleiton Ferreira Maciel Brito, Jeanne Mariel Brito de Moura Maciel, and Fundação de Amparo à Pesquisa do Estado do Amazonas
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trabalho ,Polo Industrial de Manaus ,organização da produção ,globalização - Abstract
O objetivo deste artigo é deslindar as principais transformações do trabalho ocorridas no espaço produtivo da Zona Franca de Manaus. Com tal propósito, é feita uma recuperação histórica e teórica das pesquisas realizadas no Polo Industrial de Manaus (PIM) no sentido de apontar, primeiro, as características do trabalho desde o início da década de 1970 até a primeira década do século XX. Segundo, busca-se indicar as respostas conceituais elaboradas pelos pesquisadores para a compreensão de mudanças e continuidades no mundo do trabalho de Manaus. Terceiro, dentro de um contexto de metamorfoses da economia mundial, dos dilemas políticos nacionais e da disputa feita pela classe trabalhadora local, o artigo delineia os padrões organizacionais oriundos de quatro décadas do PIM, e aborda o tipo de trabalho visualizado nas pesquisas mais recentes. Ademais, a chegada de novos atores produtivos no início do milênio, como os chineses, levanta questões teóricas novas, além de abrigar um mundo do trabalho fértil para a exploração sociológica. Uma agenda de pesquisas envolvendo essa temática compõe a parte final do artigo.
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- 2019
39. VISIBILIDADE DO INDÍGENA EM SITUAÇÃO URBANA NAS MICRORREGIÕES DO ESTADO DO AMAZONAS A PARTIR DO CENSO DEMOGRÁFICO
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Marcelo Rocha Radicchi, (FAPEAM/RH-Interiorização) Fundação de Amparo à Pesquisa do Estado do Amazonas, Escola Nacional de Saúde Pública/FIOCRUZ, and (CAPES/PDSE) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
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Condições socieconômicas de populações indígenas no Brasil ,Demografia ,Antropologia ,Saúde ,Características da população ,População indígena ,Fatores Socioeconômicos - Abstract
Este trabalho comparou o perfil socioeconômico e demográfico da população indígena residente em área urbana nas microrregiões do estado do Amazonas com não-indígenas. Analisou-se dados do Universo extraídos do SIDRA/IBGE, Censo Demográfico de 2010. Considerou-se as treze microrregiões do estado. O Amazonas é um estado de maioria parda e urbana (79,1%), com os indígenas perfazendo 4,8% do total. Na situação urbana, em 11 das 13 microrregiões, a população indígena feminina é maior. As pirâmides demográficas indígenas apresentam base alargada, indicativa de uma população jovem. O percentual médio de alfabetização dos indígenas é o menor comparando com as demais categorias de cor/raça. Os indígenas são os mais frequentes na categoria “sem rendimento” em 6 microrregiões e se concentram na faixa de rendimento “até um salário mínimo”. A situação socioeconômica desfavorável dos indígenas urbanos corrobora os resultados de outras investigações sobre demografia indígena. Sugere-se expandir as análises de modo a considerar, entre outros aspectos, dados acerca de pertencimento étnico específico, podendo ser realizado a partir do Banco Multidimensional de Estatísticas (BME) do IBGE.
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- 2020
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40. Contributing to Elimination of Cross-Border Malaria Through a Standardized Solution for Case Surveillance, Data Sharing, and Data Interpretation: Development of a Cross-Border Monitoring System
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Benoît van Gastel, Margarete do Socorro Mendonça Gomes, Lise Musset, Emmanuel Roux, Emilie Mosnier, Raphael de Freitas Saldanha, A. Carbunar, Christovam Barcellos, Alice Sanna, Théophile Mandon, Paulo Cesar Peiter, Christophe Charron, Anapaula Martins Mendes, Jean-Christophe Desconnets, B. Guarmit, Institute of Scientific and Technological Communication and Information in Health / Instituto de Comunicação e Informação Científica e Tecnológica em Saúde [Rio de Janeiro] (ICICT), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), LMI Sentinela [Rio de Janeiro], Institut de Recherche pour le Développement (IRD)-Universidade de Brasilia [Brasília] (UnB)-Fundação Oswaldo Cruz (FIOCRUZ), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Centres Délocalisés de Prévention et de Soins (CDPS), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Pôle des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane française], UMR 228 Espace-Dev, Espace pour le développement, Université de Guyane (UG)-Université des Antilles (UA)-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM), Superintendência de Vigilância em Saúde do Amapá (SVS-AP), Universidade Federal do Amapá [Oiapoque, Brésil] (UNIFAP), Réseau International des Instituts Pasteur (RIIP), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Institut Pasteur de la Guyane, Agence Régionale de la Santé [Cayenne, Guyane française] (ARS), This work was funded by the following entities: the Fighting malaria: from 'global war' to 'local guerrillas' at international borders project, part of the Grand Challenges Explorations Round 18 program funded by the Bill and Melinda Gates Foundation (investment ID OPP1171795), the GAPAM-Sentinela (Guyane Française – Amapá – Amazonas – Malária: Sítio Sentinela Transfronteiriça do Observatório Clima e Saúde) project, part of the Guyamazon program funded by the French National Research Institute for Sustainable Development (Institut de Recherche pour le Développement [IRD]), CIRAD (Centre de Coopération Internationale en Recherche Agronomique pour le Développement), the French Guiana territorial collectivity, the French Embassy in Brazil, FAPEMA (Fundação de Amparo à Pesquisa do Estado do Maranhão), FAPEAP (Fundação de Amparo à Pesquisa do Estado do Amapá), and FAPEAM (Fundação de Amparo à Pesquisa do Estado do Amazonas), the ODYSSEA (Observatory of the Dynamics of Interactions Between Societies and Environment in the Amazon) project, part of the European Union’s Horizon 2020 Research and Innovation Program funded by the European Union (Marie Skłodowska Curie grant agreement No. 691053), the Joint International Laboratory (Laboratoire Mixte International [LMI]) Cross-border observatories of climate, environment and vector-borne diseases - Sentinel site of the Brazilian Climate and Health Observatory (LMI Sentinela), under the leadership of the IRD, Fiocruz, and Brasilia University, Fiocruz and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Brazil - Finance Code 001, and Santé Publique France. We are also grateful for support from PrInt (Programa de Internacionalização) Fiocruz-CAPES Program., The authors are grateful to Frédéric Théveny (IRD, Cayenne IRD Center, French Guiana) for his technical assistance in the operational implementation of the system. The authors are also very grateful to Mathilde Isar, Julie Margaillan, and Pierre Bos, from the legal department of the IRD, for their assistance in obtaining the authorization from the French data protection authority (CNIL)., Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Institut de Recherche pour le Développement (IRD)-Universidade de Brasilia [Brasília] (UnB)-Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM)-Université de Guyane (UG)-Université des Antilles (UA), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Laboratoire de Parasitologie [Cayenne, Guyane française], Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française] (CCOMS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), and Roux, Emmanuel
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surveillance ,cross-border malaria ,Computer science ,Reuse ,Scientific evidence ,0302 clinical medicine ,data interoperability ,[SHS.STAT] Humanities and Social Sciences/Methods and statistics ,[INFO.INFO-DB] Computer Science [cs]/Databases [cs.DB] ,data visualization ,030212 general & internal medicine ,education.field_of_study ,[SHS.STAT]Humanities and Social Sciences/Methods and statistics ,Emigration and Immigration ,Reference Standards ,French Guiana ,3. Good health ,Population Surveillance ,Public aspects of medicine ,RA1-1270 ,Raw data ,Brazil ,[INFO.INFO-WB] Computer Science [cs]/Web ,[SHS.INFO]Humanities and Social Sciences/Library and information sciences ,030231 tropical medicine ,Population ,Health Informatics ,[SHS.INFO] Humanities and Social Sciences/Library and information sciences ,03 medical and health sciences ,Data visualization ,parasitic diseases ,medicine ,Humans ,Disease Eradication ,education ,Original Paper ,[INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB] ,Information Dissemination ,business.industry ,[INFO.INFO-WB]Computer Science [cs]/Web ,Public Health, Environmental and Occupational Health ,medicine.disease ,Data science ,Malaria ,Visualization ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Data quality ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
Background Cross-border malaria is a significant obstacle to achieving malaria control and elimination worldwide. Objective This study aimed to build a cross-border surveillance system that can make comparable and qualified data available to all parties involved in malaria control between French Guiana and Brazil. Methods Data reconciliation rules based on expert knowledge were defined and applied to the heterogeneous data provided by the existing malaria surveillance systems of both countries. Visualization dashboards were designed to facilitate progressive data exploration, analysis, and interpretation. Dedicated advanced open source and robust software solutions were chosen to facilitate solution sharing and reuse. Results A database gathering the harmonized data on cross-border malaria epidemiology is updated monthly with new individual malaria cases from both countries. Online dashboards permit a progressive and user-friendly visualization of raw data and epidemiological indicators, in the form of time series, maps, and data quality indexes. The monitoring system was shown to be able to identify changes in time series that are related to control actions, as well as differentiated changes according to space and to population subgroups. Conclusions This cross-border monitoring tool could help produce new scientific evidence on cross-border malaria dynamics, implementing cross-border cooperation for malaria control and elimination, and can be quickly adapted to other cross-border contexts.
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- 2020
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41. Individual variation in feather corticosterone levels and its influence on haemosporidian infection in a Neotropical bird
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Janice H. Dispoto, Alan Fecchio, Mariane Bosholn, Jason D. Weckstein, Marina Anciães, Diego Gil, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fundação de Amparo à Pesquisa do Estado do Amazonas, and Fundaçao Capes (Brasil)
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0106 biological sciences ,Leucocytozoon ,endocrine system ,Plasmodium ,animal structures ,Zoology ,Lepidothrix ,010603 evolutionary biology ,01 natural sciences ,010605 ornithology ,Predation ,chemistry.chemical_compound ,Glucocorticoid ,Avian malaria ,Corticosterone ,medicine ,polycyclic compounds ,Manakin ,Amazon ,Ecology, Evolution, Behavior and Systematics ,biology ,medicine.disease ,biology.organism_classification ,Avian ecophysiology ,chemistry ,Haemoproteus ,Feather ,visual_art ,visual_art.visual_art_medium ,Animal Science and Zoology ,hormones, hormone substitutes, and hormone antagonists ,Autoecology - Abstract
Corticosterone (CORT) is the main glucocorticoid hormone of amphibians, reptiles, birds and some mammals. This hormone may have evolved as an adaptive metabolic mechanism, in part because increased concentrations of CORT are essential for individuals to manage energy resources and thus cope with negative perturbations such as predation and storms. The benefits of CORT are offset by costs, because elevated levels can suppress inflammatory responses of individuals, making them more susceptible to parasites and pathogens. In this study, we investigated the relationships between feather CORT levels, infection status and diversity of haemosporidian parasites in the Blue-crowned Manakin Lepidothrix coronata, considering possible effects related to the sex and age of individuals. We predicted higher levels of feather CORT in infected individuals. We observed that feather CORT levels were similar among individuals of different sexes and ages. Although haemosporidian infection status did not vary among sexes, occurrence probability was higher among younger individuals, which may indicate that the less developed immune system of these individuals makes them more susceptible to avian malaria. Contrary to expectations, we found that feather CORT levels were not associated with the infection status and diversity of haemosporidian parasites. That haemosporidian occurrence probability does not increase with elevated feather CORT levels suggests that individuals are not immunosuppressed by elevated levels of this hormone, at least to the extent that feather CORT truly reflects individual differences in the level of this hormone., The field data collection was based upon research supported by the Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico (UNIVERSAL number 471092/2012-6 Faixa C to M.A.) and by Fundacao de Amparo a Pesquisa do Estado do Amazonas (PRONEX proj. 003/2009, number 653/2009 to M.A. and Albertina Lima). Hormone analysis was funded by Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico (Ciencia sem Fronteiras Chamada No. 71/2013 to M.A., D.G. and Regina Macedo). Haemosporidian laboratory work was funded by NSF DEB-1503804 to J.D.W. During the project, M.B. received a fellowship from Fundacao de Amparo a Pesquisa do Estado do Amazonas (FAPEAM) and Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico (CNPq). A.F. was supported by a postdoctoral fellowship (PNPD scholarship) from Coordenacao de Aperfeicoamento de Pessoal de Nıvel Superior (CAPES).
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- 2019
42. ESTUDO DOS DESLOCAMENTOS URBANOS DE COARI, ITACOATIARA E PARINTINS E POSSÍVEIS INFLUÊNCIAS DA TOPOGRAFIA NA DIVISÃO MODAL / STUDY OF URBAN DISPLACEMENT OF THE CITIES COARI, ITACOATIARA AND PARINTINS AND POSSIBLE INFLUENCES OF THE TOPOGRAPHY IN THE MODAL SPLIT
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Silva, Jouber Costa, Souza, Geraldo Alves, and Fundação de Amparo à Pesquisa do Estado do Amazonas - FAPEAM
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Mobilidade urbana ,Interior do Amazonas ,Topografia ,Modais Motorizados ,Modais não motorizados ,Urban Mobility ,Amazon countryside ,Topography ,Motorized modal ,Non-motorized modal - Abstract
This research was order to study the urban displacements in Amazonas countryside, as well understand the similarities and differences of urban displacement and identify the influence of topography for the use of modal. For this three cities were chosen: Coari, Itacoatiara and Parintins. As hypothesis left is the idea that in cities with more rugged topography (Coari) the use of non-motorized modes must be smaller than in cities with a flatter topography (Itacoatiara e Parintins). To obtain the results were performed two weeks duration with field work in each city. During the field were recorded five modes: car; motorcycle; bike taxi; mode walking and bicycle. The data demonstrate a greater use of motorcycles in all the surveyed cities. The car has a higher percentage of their use in the city in Itacoatiara and Parintins. The pedestrian mode showed no significant variation between cities. In the case of the bicycle was found less use in Coari. So what can be concluded is that the initial hypothesis of the project was confirmed in part, in addition to the topography, the economic factor and the domestic and foreign policy have changed the strategies of the population as regards the choice of modal for urban displacement. O presente estudo tem como objetivo estudar os deslocamentos urbanos em cidade do interior do Amazonas, bem como entender as semelhanças e diferenças dos deslocamentos urbanos e identificar a influência da topografia para com o uso dos modais. Para isso foram escolhidas três cidades: Coari, Itacoatiara e Parintins. Como hipótese, partiu-se da idéia que em cidades com topografia mais acidentada (Coari) o uso dos modais não motorizados devem ser menor que em cidades com uma topografia mais plana (Itacoatiara e Parintins). Para obtenção dos resultados realizou-se trabalhos de campo durante duas semanas em cada cidade. Contabilizou-se cinco formas de deslocamentos: carro; motocicleta; moto táxi; modo a pé e bicicleta. Os dados demonstram um maior uso da motocicleta em todas as cidades pesquisadas. O carro possui maior percentagem de uso nas cidades de Itacoatiara e Parintins. O modo a pé não apresentou variação significativa entre as cidades. No caso da bicicleta verificou-se um menor uso em Coari. Portanto, conclui-se que a hipótese inicial do projeto foi, em parte, confirmada, e que além da topografia, o fator econômico e a política nacional têm modificado as estratégias da população no que se refere à escolha do modal para os deslocamentos urbanos.
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- 2018
43. The role of Pleistocene climate change in the genetic variability, distribution and demography of Proechimys cuvieri and P. Guyannensis (Rodentia: Echimyidae) in northeastern Amazonia
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François Catzeflis, Claudia Regina Silva, Camila C. Ribas, Maria Nazareth Ferreira da Silva, Rafael N. Leite, Duke S. Rogers, Benoit de Thoisy, Instituto Nacional de Pesquisas da Amazônia (INPA), Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá (IEPA), Estado do Amapa, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Brigham Young University (BYU), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), We thank Fundação de Amparo à Pesquisa do Estado do Amapá (FAPEAP), Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM) and Intitut de Recherche pour le Développement (IRD) for financial support through the Guyamazon II research program (Process 250203021/2014). The project benefited from the support of an ‘‘Investissement d’Avenir’’ grant managed by Agence Nationale de la Recherche (CEBA, Ref. ANR-10-LABX-25-01). We also thank FAPEAP for support through the Thesis Funding Programme (Process 250203052/2014). CRS thanks Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for a scholarship. RNL was supported by CNPq (150069 / 2014-6, 457267 / 2014-3)., Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)
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0106 biological sciences ,0301 basic medicine ,Sympatry ,Proechimys Guyannensis ,Heredity ,Genetic Distance ,Marine and Aquatic Sciences ,Forests ,01 natural sciences ,Geographical locations ,Species Habitat ,Pleistocene Epoch ,Haplotype ,Proechimys cuvieri ,Phylogeny ,Data Management ,River ,Animalss ,Quaternary Period ,Multidisciplinary ,Rodent ,Geography ,Ecology ,biology ,[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] ,Species Distribution ,Geology ,Phylogenetic Analysis ,Cytochromes b ,Terrestrial Environments ,Phylogenetics ,Pleistocene ,Genetic Mapping ,Phylogeography ,Biogeography ,Genetic Variability ,Genetic structure ,Medicine ,Proechimys guyannensis ,Gene Structures ,Brazil ,Research Article ,Freshwater Environments ,Systematics ,Computer and Information Sciences ,Gene Sequence ,Science ,Climate Change ,Rodentia ,Cytochromes B ,010603 evolutionary biology ,Ecosystems ,Proechimys Cuvieri ,03 medical and health sciences ,Rivers ,Animals Tissue ,Genetics ,Molecular Clock ,Animals ,Evolutionary Systematics ,Controlled Study ,Taxonomy ,Demography ,Evolutionary Biology ,Population Biology ,Brasil ,Ecology and Environmental Sciences ,Cytochrome B ,Biology and Life Sciences ,Aquatic Environments ,Paleontology ,Genetic Variation ,Geologic Time ,Bayes Theorem ,Echimyidae ,Bodies of Water ,South America ,15. Life on land ,biology.organism_classification ,Nonhuman ,030104 developmental biology ,Haplotypes ,Earth Sciences ,Cenozoic Era ,Species richness ,People and places ,Paleogenetics ,Population Genetics - Abstract
The spiny rats, genus Proechimys, have the highest species richness within the Echimyidae family, as well as species with high genetic variability. The genus distribution includes tropical South America and Central America south to Honduras. In this study, we evaluate the phylogeographic histories of Proechimys guyannensis and P. cuvieri using cytochrome b, in a densely sampled area in northeastern Amazon where both species are found in sympatry in different environments. For each species, Bayesian and Maximum Likelihood phylogenetic analysis were congruent and recovered similar clades in the studied area. Bayesian phylogenetic analysis using a relaxed molecular clock showed that these clusters of haplotypes diversified during Pleistocene for both species. Apparently, the large rivers of the region did not act as barriers, as some clades include specimens collected from opposite banks of Oiapoque, Araguari and Jari rivers. Bayesian skyline plot analysis showed recent demographic expansion in both species. The Pleistocene climatic changes in concert with the geologic changes in the Amazon fan probably acted as drivers in the diversification that we detected in these two spiny rats. Proechimys cuvieri and P. guyannensis show genetic structure in the eastern part of the Guiana region. Greater genetic distances observed in P. guyannensis, associated with highly structured groups, suggest that more detailed studies of systematics and ecology should be directed to this species. © 2018 Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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- 2018
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44. A RESPONSABILIDADE CIVIL AMBIENTAL DO ESTADO NA OCUPAÇÃO DESORDENADA DO NOVA CONQUISTA, MANAUS
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Bentes, Dorinethe dos Santos, Castro, Aline Vasques, Fabio, Gabrielle Stoco, FAPEAM - Fundação de Amparo à Pesquisa do Estado do Amazonas, and UFAM - Universidade Federal do Amazonas
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Responsabilidade civil ambiental. Ação Civil Pública. Ação Popular. Área de ocupação desordenada. Bairro Nova Conquista ,Ocupações Desordenadas nas Zonas Urbanas de Manaus ,Direito Ambiental e do Trabalho - Abstract
Para se descrever a responsabilidade civil ambiental do Poder Público na ocupação desordenada de Nova Conquista, Zona Leste de Manaus, foi utilizado o método fenomenológico e o monográfico. Destacou-se dois importantes tópicos: primeiro, os meios processuais colocados à disposição da sociedade, como a Ação Civil Pública e a Ação Popular, para se pleitear a recomposição da área afetada; segundo, a importância da participação do Ministério Público na proteção dos direitos difusos. Verificou-se, in loco, a extrema dificuldade em se proceder com a urbanização destes locais devido à falta de planejamento por parte dos órgãos responsáveis, assim como a dificuldade em se mensurar o dano e reestabelecer o status quo ante. Assim, sugeriu-se a facilitação na aquisição da casa própria por meio de programas habitacionais, e a promoção de uma efetiva reforma urbana na cidade de Manaus. THE STATE CIVIL ENVIRONMENTAL RESPONSIBILITY IN DISORDERLY OCCUPATION OF NOVA CONQUISTA, MANAUSAbstract: In order to describe the environmental liability of the government in the disorderly occupation of Nova Conquista, East Zone of Manaus, we used the phenomenological method and monographic method. Stood out two important topics: First, the procedural means placed at the disposal of society, such as Public Civil Action and the Popular Action, to claim the recovery of the affected area; second, the importance of involving the public prosecutor in the protection of diffuse rights. It was found, in locu, the extreme difficulty in proceeding with the urbanization of these sites due to lack of planning by the responsible agencies as well as the difficulty in measuring the damage and restore the status quo ante. Thus, it was suggested in facilitating home ownership through housing programs, and the promotion of an effective urban renewal in the city of Manaus.Keywords: Environmental Liability. Civil Action. Popular Action. Area disorderly occupation. Neighborhood Nova Conquista.
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- 2017
45. O PROCESSO DE MUDANÇA EM UMA INSTITUIÇÃO DE ENSINO SUPERIOR SOBRE A ÓTICA DA RESPONSABILIDADE SOCIAL UNIVERSITÁRIA
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Cristhiane Martins Lima, Vinícius Costa da Silva Zonatto, Adriela de Marchi, Miguel Angel Verdinelli, Patrinês Aparecida França Zonatto, and Fundação de Amparo à Pesquisa do Estado do Amazonas – FAPEAM.
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Community and Home Care ,Responsabilidade Social Universitária. Instituição de Ensino Superior. Relatórios Anuais de Gestão - Abstract
Este estudo investigou as ações de Responsabilidade Social Universitária desenvolvidas em uma universidade federal brasileira, propostas nos relatórios anuais de gestão, utilizando o modelo teórico da Pirâmide Institucional de Calderón (2006) e os princípios e valores propostos por Jiménez De La Jara, Fontecilla e Troncoso (2006). Para tanto, foi realizado um estudo longitudinal com análise de conteúdo dos relatórios de gestão do período de 2005 a 2014. Os resultados obtidos na análise documental mostram que, no decorrer dos anos, as ações voltadas para a Responsabilidade Social vêm crescendo e se ampliando, estando principalmente ligadas a projetos e programas voltados para a pesquisa e extensão universitária. As práticas evidenciadas revelam que a instituição busca a excelência no ensino público e na produção científica; a partir de servidores capacitados, valorizados e comprometidos com a missão; adequação da infraestrutura; contribuição para o desenvolvimento social e regional por meio de processos administrativos, acadêmicos e técnicos; a criação de novas estratégias que permitam a democratização do acesso e a permanência no ensino, focalizando, principalmente, aqueles que se encontram excluída por decorrência das desigualdades sociais. Os resultados encontrados nesta pesquisa permitem concluir que a IES desenvolve ações de Responsabilidade Social Universitária. Também sugerem a validação do modelo teórico de análise proposto por Calderón (2006), bem como os princípios e valores propostos por Jiménez De la Jara et al. (2006) para o desenvolvimento de uma cultura de Responsabilidade Social Universitária no âmbito de Universidades brasileiras.
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- 2017
46. A autonomia de Deus: um estudo semântico da palavra nāham em Gênesis 6.6
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Ribamar Mendes Filho, José Jacinto and FAPEAM - Fundação de Amparo à Pesquisa do Estado do Amazonas
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Imutabilidade ,Arrependimento ,Autonomia ,Estudo Semântico ,Teologia Bíblica com ênfase em Antigo Testamento - Abstract
Este ensaio tem como objetivo propor uma reflexão a respeito da imutabilidade e o arrependimento de Deus: pois Deus sendo imutável, também é sujeito que se arrepende. Estudando os conceitos sobre imutabilidade e o arrependimento de Deus, o texto partirá do pressuposto da autonomia de Deus. O breve tratado dos conceitos terá que considerar o estudo das palavras nāham e shuv, mediante uma abordagem gramatico-literal, que observará o discurso sobre Deus e sobre o homem/mulher, no que se refere ao arrependimento. Fazer um estudo semântico da palavra nāham partindo da comparação das traduções Almeida Revista e Atualizada (ARA), Nova Versão Internacional (NVI), e Nova Tradução da Linguagem de Hoje (NTLH).
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- 2016
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47. Estratégias empresariais e esfera pública: a Zona Franca de Manaus como colonização sócio-política
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Cleiton Ferreira Maciel, Jeanne Mariel Brito de Moura, Fundação de Amparo à Pesquisa do Estado do Amazonas- FAPEAM, and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior- CAPES
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Estratégias empresariais ,esfera pública ,Zona Franca de Manaus ,sociologia política - Abstract
Neste texto, buscamos discutir as estratégias empresariais como forma política de “colonizar” a esfera pública. Nessa perspectiva, configuraremos aqui, em um primeiro momento, um mapa conceitual acerca da relação capital-trabalho no ambiente produtivo da Zona Franca de Manaus, (ZFM) estabelecendo, em seguida, pontos de discussão com alguns direcionamentos teóricos de Hannah Arendt, Walter Benjamin, Edward Said, Antônio Gramsci e Nancy Fraser. A hipótese que lançamos neste artigo e que buscamos problematizar é a de que a Zona Franca de Manaus é uma invenção histórica sobre o lugar, que no século XX vai ganhar forma de “não-lugar”, sendo constituído enquanto espaço transnacionalizado e simbolicamente construído, permeado por interesses políticos e econômicos que transcendem a esfera do “local”. Essa invenção histórica tem como efeito simbólico e prático o enevoamento de contradições sociais que ocorrem no interior da nua e crua realidade do Amazonas, e será usada pela elite local e nacional como ferramenta ideológica para diluir conflitos e mascarar tensões. Uma tentativa da esfera privada de colonizar a esfera pública, portanto.
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- 2016
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48. SISTEMA DE INFORMAÇÃO GEORREFENCIADO, APLICADO AO PROJETO PROSAMIM-1/MANAUS - AMAZONAS
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Ferreira, Jose Ednaldo Zane, Lima, Aline Maria Meiguins de, Silva Junior, João de Athaydes, Mendes, Ronaldo Lopes Rodrigues, and Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)
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Interdisciplinar ,Planejamento ,web ,sistemas de informação ,Planning ,information systems - Abstract
Os sistemas de informação aplicados ao planejamento urbano permitem uma melhor gestão do território, por meio da espacialização das unidades componentes e visualização de suas inter-relações. O objetivo deste trabalho foi desenvolver um sistema de informações das áreas de atuação do Programa Social e Ambiental dos Igarapés de Manaus - PROSAMIM-1 que auxiliasse o seu dimensionamento no município de Manaus-AM. O PROSAMIM-1 representa um dos projetos de ação ambiental mais significativos dos últimos 50 anos executados na cidade de Manaus, cujo impacto deve ser publicamente disseminado, permitindo assim a maior interação social do projeto. O sistema de informações projetado também tem a função de atuar como um repositório para o registro de sua evolução histórica. A metodologia empregada é associada a uma pesquisa aplicada, com a sistematização das informações do projeto, oriundas das bases e registros produzidos pelos órgãos responsáveis e sua estruturação em um mecanismo de consulta e pesquisa georreferenciado via web. O produto gerado possibilitou a localização visual das áreas do PROSAMIM-1 e a proposição de ações que auxiliem o planejamento urbano e estratégico das áreas do entorno., Information systems applied to urban planning allow better territory management, through the composing units' spatial distribution and a view of their interrelation. The aim of this study was to develop an information system of the areas of the Social and Environmental Program and Streams of Manaus - PROSAMIM-1 that could help its sizing in Manaus-AM. The PROSAMIM-1 is one of the most significant environmental project over the last 50 years executed in the Manaus city, and its impact should be publicly disseminated, thus allowing greater social interaction design. The information system designed also has the function of acting as a repository for the registration of its historical evolution. The methodology is associated with applied research, with the systematization of project information, derived bases and records produced by the responsible organs and its organization in a consultative mechanism and georeferenced web search. The product created enabled the visual location of PROSAMIM-1 areas and propose actions to assist the strategic and urban planning on its surrounding areas.
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- 2016
49. A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
- Author
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Benoit Witkowski, Hans-Peter Fuehrer, Garib Das Thakur, Céline Barnadas, Djibrine Djalle, Michael Ramharter, Mindy Leelawong, Wasif Ali-Khan, Harald Noedl, Bouasy Hongvanthong, Mohammad Shafiul-Alam, Hypolite Muhindo-Mavoko, Abdillahi Mohamed Hassan, Judith Straimer, Nimol Khim, Kigbafori D. Silué, Kaknika Loch, Barbara H. Stokes, Maria Dorina Bustos, Laura Berne, Dylan R. Pillai, Ayola A. Adegnika, Lin Hua Tang, Rotha Eam, Saorin Kim, Alioune Dieye, Mei Li, Carole E. Eboumbou-Moukoko, Lydie Canier, Marian Warsame, Didier Menard, David A. Fidock, Yap Boum, Lyndes Wini, Abdiqani Sheikh-Omar, Patrick Tshibangu-Wa-Tshibangu, Maman Laminou Ibrahim, Mohammad Jahirul-Karim, Malen Ken, Monique A. Dorkenoo, Sócrates Herrera, Odile Mercereau-Puijalon, Lise Musset, Valentine Duru, Eric Legrand, Maniphone Khanthavong, Pascal Ringwald, Bruno Pradines, Sandrine Houzé, Rachida Tahar, Olukemi K. Amodu, Johann Beghain, Sandie Menard, Liwang Cui, Colin J. Sutherland, Jun Hu Chen, Kesara Na-Bangchang, Khin Lin, Michael Nambozi, Rithea Leang, Jean Christophe Barale, Milijaona Randrianarivelojosia, Marcus V. G. Lacerda, Sophy Chy, Frédéric Ariey, Jean-Bosco Ouédraogo, Isabelle Morlais, Maria de Fátima Ferreira-da-Cruz, Lubin Jiang, Christophe Rogier, Jun Cao, Peter G. Kremsner, Bui Quang-Phuc, Inès Vigan-Womas, Din Syafruddin, Jetsumon Sattabongkot, Shigeyuki Kano, Abebe A. Fola, Louis Collet, Karamoko Niaré, Thierry Fandeur, Sedigheh Zakeri, Sodiomon B. Sirima, Antoine Berry, Jean Baptiste Mazarati, Fe Espino, Ghulam Rahim-Awab, Chanra Khean, Offianan Andre Toure, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Génétique et Génomique des Insectes vecteurs, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Centre de Recherche Médicale de Lambaréné, Albert Schweitzer, Leiden University Medical Center (LUMC), Universiteit Leiden, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), University of Ibadan, Nangarhar University, Mahidol University [Bangkok], The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Papua New Guinea Institute for Medical Research (PNGIMR), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Mbarara University of Science and Technology [Mbarara] (MUST), Epicentre Ouganda [Mbarara] [Médecins Sans Frontières], Epicentre [Paris] [Médecins Sans Frontières], World Health Organization (WHO), country office for Thailand, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), JiangSu University, National Institute of Parasitic Diseases, Center for Disease Control, China, Centre Hospitalier de Mayotte, Pennsylvania State University (Penn State), Penn State System, Epidemiology and Disease Control division (EDCD), Ministry of Public Health [Nepal], Institut Pasteur de Dakar, Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Institut Pasteur de Bangui, Université de Lomé [Togo], Université de Douala, Centre Pasteur du Cameroun, Research Institute for Tropical Medicine, Centre International de Recherches Médicales de Franceville (CIRMF), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), University of Gondar, Institute of Parasitology [Vienna], University of Veterinary Medicine, Vienna, World Health Organisation (WHO), country office for Somalia, Caucaseco scientific research center = Centro de Investigación Científica Caucaseco, National Center for Malariology, Parasitology and Entomology, Ministry of Health [Mozambique], Hôpital Bichat - Claude Bernard, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5), Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES), Directorate General of Health Services (DGHS), Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences (IPS-CAS), National Center for Global Health and Medicine [Japan] (NCGM), Institut Pasteur du Laos, Instituto Leônidas e Maria Deane - Fiocruz Amazônia [Manaus, Brésil] (ILMD), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), National Center for Malaria Control, Parasitology and Entomology, Ministry of Health of Cambodgia, Henry M. Jackson Foundation for the Advancement of Military Medicine (HJM), U.S. Naval Medical Research, The Department of Medical Research (Upper Myanmar), Rwanda Biomedical Center (RBC), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement [Yaoundé, Cameroun] (IRD [Cameroun]), Institut de Recherche pour le Développement (IRD), University of Kinshasa (UNIKIN), University of Antwerp (UA), Institut Pasteur de la Guyane, Thammasat University (TU), Tropical Diseases Research Center (TDRC), Université de Bamako, Medizinische Universität Wien = Medical University of Vienna, Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz, Medicines for Malaria Venture (MMV), Université de Genève = University of Geneva (UNIGE), Global Malaria Programme, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence du Paludisme, Institut Pasteur de Madagascar, Ministry of Health and Human Services [Somalia], Centre Suisse de Recherches Scientifiques en Cote d'Ivoire [Abidjan] (CSRS-CI), Université Félix Houphouët-Boigny (UFHB), Groupe de recherche action en santé (GRAS), London School of Hygiene and Tropical Medicine (LSHTM), University of Hasanuddin, Eijkman Institute for Molecular Biology [Jakarta], Institut Pasteur de Côte d'Ivoire, Ministry of Health and Medical Services, Institut Pasteur d'Iran, Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Microbiologie structurale - Structural Microbiology (Microb. Struc. (UMR_3528 / U-Pasteur_5)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Columbia University Irving Medical Center (CUIMC), Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Supported by the Institut Pasteur Paris, Institut Pasteur International Division, Institut Pasteur Cambodia, and the World Health Organization, by a grant (ANR-10-LABX-62-IBEID) from the French Government Investissement d’Avenir program, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases', a grant from Natixis Banques, a grant (R01I109023, to Dr. Fidock) from the National Institutes of Health, grants from the Fiocruz Fundação Oswaldo Cruz, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Fundação de Amparo à Pesquisa do Estado do Amazonas, the Brazilian National Council for Scientific and Technological Development, the Agence Nationale de la Recherche (13-BSV3-0018-01 and11-BSV7-009-01), the Austrian Federal Ministry of Science, Research, and Econo-my, the Calgary Laboratory Services, the Centre International de Recherches Médicales de Franceville, the European and Developing Countries Clinical Trials Partnership (CT-2004-31070-001), the Drugs for Neglected Diseases Initiative, the Else Kroener Fresenius Stiftung, the Holger Poehlmann Stiftung, the European Community African–European Research Initiative 'IDEA' (HEALTH-F3-2009-241642), the Fonds Wetenschappelijk Onderzoek, the Vlaamse Interuniversitaire Raad–Universitaire Ontwikkelingssamenwerking, the Belgian Technical Cooperation in Democratic Republic of Congo, the European Community Seventh Framework Program (FP7/2007-2013, 242095, and 223601), the European Commission (REGPOT-CT-2011-285837-STRONGER), the Ministère de la Santé Publique du Niger (Laboratoire National de Référence Résistance aux Antipaludiques), the Foundation of National Science and Technology Major Program (2012ZX10004-220), the French Ministry of Health (Institut National de Veille Sanitaire), the Global Fund to Fight AIDS, Tuberculosis and Malaria, the 5% Initiative program (French Ministry of Foreign Affairs, France Expertise Internationale, 12INI109), the Institut Pasteur de Madagascar, the Government of the Philippines, the Institut de Recherche pour le Développement, the Foundation des Treilles, the Délégation Générale pour l’Armement (PDH-2-NRBC-4-B1-402), the Institut Pasteur de Bangui, the International Society for Health Research and Training, the Malaria Research Initiative Bandarban, Vienna, International Centre for Diarrhoeal Disease Research, Bangladesh, the Médecins sans Frontières (Centre Opérationnel Paris, France), Medicines for Malaria Venture, the National Research Council of Thailand, the Thammasat University, the National Natural Science Foundation of China (81271870, 81361120405, and 81271863), the Natural Science Foundation of Jiangsu Province (BK20130114 and BK20150001), the Jiangsu Science and Technology Department (BM2015024), the National Institutes of Health (R01 AI11646601, AI109023, and ICEMR U19AI089702, U19AI089672), the Pasteur Institute of Iran, the Malaria Division of the Iranian Center for Diseases Management and Control, Public Health England (Malaria Reference Service Contract), the Government of Rwanda, the U.S. Department of Defense Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (P0463-14-N6), the Fogarty International Center of the National Institutes of Health training (D43 TW007393), the Mahidol-Oxford Research Unit, the Government of Japan (Science and Technology Agency, Agency for Medical Research and Development, Japan International Cooperation Agency, and Science and Technology Research Partnership for Sustainable Development), and the President’s Malaria Initiative of the U.S. Agency for International Development., The KARMA Consortium, ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-13-BSV3-0018,MALARTRES,Résistance de Plasmodium aux antipaludiques de la famille des artémisinines(2013), ANR-13-BSV7-0009,NEBEDIV,Le rôle des ennemis naturels dans la diversité béta des arbres tropicaux(2013), European Project: CT-2004-31070-001,EDCCTP, European Project: HEALTH-F3-2009-24164,IDEA, European Project: FP7/2007-2013, 24209,FP7, European Project: FP7/2007-2013, 22360,FP7, European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), European Project: 242095,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,EVIMALAR(2009), European Project: 223601,EC:FP7:HEALTH,FP7-HEALTH-2007-B,MALVECBLOK(2009), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], Fundação Oswaldo Cruz (FIOCRUZ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Genève (UNIGE), INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Université Paris Diderot - Paris 7 (UPD7)-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Eberhard Karls Universität Tübingen, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia., Centre International de Recherches Médicales de Franceville, Caucaseco scientific research center, Mère et enfant face aux infections tropicales (MERIT - UMR_D 216), National Center for Global Health and Medicine (NCGM), Instituto Leônidas e Maria Deane (ILMD), Centre de Physiopathologie Toulouse Purpan ex IFR 30 et IFR 150 (CPTP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement [Yaoundé], Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, Eijkman Institute for Molecular Biology, Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance, Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ANR-10-LABX-62-IBEID,IBEID,Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases'(2010), Van geertruyden, Jean-Pierre, and KARMA Consortium
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0301 basic medicine ,Nonsynonymous substitution ,MESH: Sequence Analysis, DNA ,Endemic Diseases ,MESH: Asia, Southeastern ,Drug Resistance ,Protozoan Proteins ,Drug resistance ,MESH: Genotype ,Lactones ,0302 clinical medicine ,Genotype ,Artemisinin ,Malaria, Falciparum ,MESH: Protozoan Proteins ,Asia, Southeastern ,MESH: Plasmodium falciparum ,Genetics ,biology ,MESH: Malaria, Falciparum ,General Medicine ,Artemisinins ,MESH: China ,3. Good health ,MESH: Endemic Diseases ,MESH: Drug Resistance ,Algorithms ,MESH: Lactones ,medicine.drug ,China ,MESH: Mutation ,030231 tropical medicine ,030106 microbiology ,Plasmodium falciparum ,MESH: Algorithms ,03 medical and health sciences ,parasitic diseases ,MESH: Artemisinins ,MESH: Polymorphism, Genetic ,medicine ,Humans ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Allele ,Polymorphism, Genetic ,MESH: Humans ,Haplotype ,Sequence Analysis, DNA ,medicine.disease ,biology.organism_classification ,Virology ,Mutation ,Human medicine ,Malaria - Abstract
Comment inK13-Propeller Mutations and Malaria Resistance, http://www.nejm.org/doi/full/10.1056/NEJMe1604520; International audience; BACKGROUND:Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)-propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale.METHODS:We analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic. Most of the samples (84.5%) were obtained from patients who were treated at sentinel sites used for nationwide surveillance of antimalarial resistance. We evaluated the emergence and dissemination of mutations by haplotyping neighboring loci.RESULTS:We identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution. In Asia, 36.5% of the K13 mutations were distributed within two areas--one in Cambodia, Vietnam, and Laos and the other in western Thailand, Myanmar, and China--with no overlap. In Africa, we observed a broad array of rare nonsynonymous mutations that were not associated with delayed parasite clearance. The gene-edited Dd2 transgenic line with the A578S mutation, which expresses the most frequently observed African allele, was found to be susceptible to artemisinin in vitro on a ring-stage survival assay.CONCLUSIONS:No evidence of artemisinin resistance was found outside Southeast Asia and China, where resistance-associated K13 mutations were confined. The common African A578S allele was not associated with clinical or in vitro resistance to artemisinin, and many African mutations appear to be neutral. (Funded by Institut Pasteur Paris and others.).
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- 2016
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50. Obtention of Li3xLa2/3−xTiO3 ceramics from amorphous nanopowders by spark plasma sintering
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I. Martinez, J. Anglada-Rivera, Y. Romaguera-Barcelay, F. Guerrero, Rosalía Poyato, Harvey Amorín, Y. Leyet, Ángela Gallardo-López, Fundação de Amparo à Pesquisa do Estado do Amazonas, European Commission, and Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)
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Materials science ,Scanning electron microscope ,Oxide ,Lithium lanthanum titanium oxide ,Spark plasma sintering ,chemistry.chemical_element ,Sintering ,02 engineering and technology ,01 natural sciences ,chemistry.chemical_compound ,0103 physical sciences ,Ceramic ,010302 applied physics ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Microstructure ,Electronic, Optical and Magnetic Materials ,Titanium oxide ,chemistry ,Chemical engineering ,visual_art ,visual_art.visual_art_medium ,Lithium ,0210 nano-technology ,Mechano synthesis - Abstract
In this work, LiLaTiO powder with nominal lithium content (x = 0.08) was synthesized by mechano synthesis method. Spark plasma sintering (SPS) was employed to prepare lithium lanthanum titanium oxide solid-state ceramic. The techniques of X-ray diffraction, high resolution scanning electron microscopy, and Raman spectroscopy were used to characterize the composition and microstructure of samples. The results showed that fine-grained ceramics with relative density of 95.5% were obtained by sintering the oxide powders at 1100°C for only 5 min., The authors would like to thank CNPq and FAPEAM Brazilian agencies for financial support n° [350405/2012–3]. Y. Romaguera-Barcelay also thanks the operation program ON.2 for their financial support (NORTE-07-0124-FEDER-000070 – Multifunctional nanomaterials).
- Published
- 2016
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