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1. A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease

Author

Mato Prado, Mireia, Puik, Jisce R., Castellano, Leandro, López-Jiménez, Elena, Liu, Daniel S. K., Meijer, Laura L., Le Large, Tessa Y. S., Rees, Eleanor, Funel, Niccola, Sivakumar, Shivan, Pereira, Stephen P., Kazemier, Geert, Zonderhuis, Babs M., Erdmann, Joris I., Swijnenburg, Rutger-Jan, Frilling, Andrea, Jiao, Long R., Stebbing, Justin, Giovannetti, Elisa, Krell, Jonathan, and Frampton, Adam E.

Published
2023
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5. Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds

Author

Li Petri, Giovanna, El Hassouni, Btissame, Sciarrillo, Rocco, Funel, Niccola, Mantini, Giulia, Zeeuw van der Laan, Eveline A., Cascioferro, Stella, Avan, Amir, Zucali, Paolo Andrea, Zaffaroni, Nadia, Lagerweij, Tonny, Parrino, Barbara, Smid, Kees, Deraco, Marcello, Granchi, Carlotta, Braczko, Alicja, Smolenski, Ryszard T., Matherly, Larry H., Jansen, Gerrit, Assaraf, Yehuda G., Diana, Patrizia, Cloos, Jacqueline, Peters, Godefridus J., Minutolo, Filippo, and Giovannetti, Elisa

Published
2020
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6. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Author

Wolpin, Brian M, Rizzato, Cosmeri, Kraft, Peter, Kooperberg, Charles, Petersen, Gloria M, Wang, Zhaoming, Arslan, Alan A, Beane-Freeman, Laura, Bracci, Paige M, Buring, Julie, Canzian, Federico, Duell, Eric J, Gallinger, Steven, Giles, Graham G, Goodman, Gary E, Goodman, Phyllis J, Jacobs, Eric J, Kamineni, Aruna, Klein, Alison P, Kolonel, Laurence N, Kulke, Matthew H, Li, Donghui, Malats, Núria, Olson, Sara H, Risch, Harvey A, Sesso, Howard D, Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C, Albanes, Demetrius, Andreotti, Gabriella, Austin, Melissa A, Barfield, Richard, Basso, Daniela, Berndt, Sonja I, Boutron-Ruault, Marie-Christine, Brotzman, Michelle, Büchler, Markus W, Bueno-de-Mesquita, H Bas, Bugert, Peter, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E, Capurso, Gabriele, Chung, Charles, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Funel, Niccola, Gaziano, J Michael, Giese, Nathalia A, Giovannucci, Edward L, Goggins, Michael, Gorman, Megan J, Gross, Myron, Haiman, Christopher A, Hassan, Manal, Helzlsouer, Kathy J, Henderson, Brian E, Holly, Elizabeth A, Hu, Nan, Hunter, David J, Innocenti, Federico, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay-Tee, Klein, Eric A, Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C, LaCroix, Andrea, Landi, Maria T, Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L, Nakamura, Yusuke, Oberg, Ann L, Owzar, Kouros, Patel, Alpa V, Peeters, Petra HM, Peters, Ulrike, Pezzilli, Raffaele, Piepoli, Ada, Porta, Miquel, Real, Francisco X, Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Shu, Xiao-Ou, Silverman, Debra T, Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Taylor, Philip R, and Theodoropoulos, George E

Subjects
Cancer, Aged, Case-Control Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, White People, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Published
2014

11. Supplementary Figure 2 from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells

Author

Avan, Amir, primary, Crea, Francesco, primary, Paolicchi, Elisa, primary, Funel, Niccola, primary, Galvani, Elena, primary, Marquez, Victor E, primary, Honeywell, Richard J., primary, Danesi, Romano, primary, Peters, Godefridus J., primary, and Giovannetti, Elisa, primary

Published
2023
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12. Supplementary Figure 1 from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells

Author

Avan, Amir, primary, Crea, Francesco, primary, Paolicchi, Elisa, primary, Funel, Niccola, primary, Galvani, Elena, primary, Marquez, Victor E, primary, Honeywell, Richard J., primary, Danesi, Romano, primary, Peters, Godefridus J., primary, and Giovannetti, Elisa, primary

Published
2023
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13. Supplementary Figure Legend from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells

Author

Avan, Amir, primary, Crea, Francesco, primary, Paolicchi, Elisa, primary, Funel, Niccola, primary, Galvani, Elena, primary, Marquez, Victor E, primary, Honeywell, Richard J., primary, Danesi, Romano, primary, Peters, Godefridus J., primary, and Giovannetti, Elisa, primary

Published
2023
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15. Supplementary Figures 1-3, Tables 1-6 from Loss of 18q22.3 Involving the Carboxypeptidase of Glutamate-like Gene Is Associated with Poor Prognosis in Resected Pancreatic Cancer

Author

Lee, Jih-Hsiang, primary, Giovannetti, Elisa, primary, Hwang, Jin-Hyeok, primary, Petrini, Iacopo, primary, Wang, Qiuyan, primary, Voortman, Johannes, primary, Wang, Yonghong, primary, Steinberg, Seth M., primary, Funel, Niccola, primary, Meltzer, Paul S., primary, Wang, Yisong, primary, and Giaccone, Giuseppe, primary

Published
2023
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16. Supplementary Figure 1 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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17. Data from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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18. Supplementary Methods from MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

Author

Giovannetti, Elisa, primary, Funel, Niccola, primary, Peters, Godefridus J., primary, Del Chiaro, Marco, primary, Erozenci, Leyla A., primary, Vasile, Enrico, primary, Leon, Leticia G., primary, Pollina, Luca E., primary, Groen, Annemieke, primary, Falcone, Alfredo, primary, Danesi, Romano, primary, Campani, Daniela, primary, Verheul, Henk M., primary, and Boggi, Ugo, primary

Published
2023
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19. Supplementary Figure 3 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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20. Supplementary Figure 8 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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21. Supplementary Figure 6 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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22. Supplementary Figure 4 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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23. Supplementary Figure 7 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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24. Supplementary Figures 1-5 from MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

Author

Giovannetti, Elisa, primary, Funel, Niccola, primary, Peters, Godefridus J., primary, Del Chiaro, Marco, primary, Erozenci, Leyla A., primary, Vasile, Enrico, primary, Leon, Leticia G., primary, Pollina, Luca E., primary, Groen, Annemieke, primary, Falcone, Alfredo, primary, Danesi, Romano, primary, Campani, Daniela, primary, Verheul, Henk M., primary, and Boggi, Ugo, primary

Published
2023
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25. Supplementary Methods from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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26. Data from MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

Author

Giovannetti, Elisa, primary, Funel, Niccola, primary, Peters, Godefridus J., primary, Del Chiaro, Marco, primary, Erozenci, Leyla A., primary, Vasile, Enrico, primary, Leon, Leticia G., primary, Pollina, Luca E., primary, Groen, Annemieke, primary, Falcone, Alfredo, primary, Danesi, Romano, primary, Campani, Daniela, primary, Verheul, Henk M., primary, and Boggi, Ugo, primary

Published
2023
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27. Supplementary Video from MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

Author

Giovannetti, Elisa, primary, Funel, Niccola, primary, Peters, Godefridus J., primary, Del Chiaro, Marco, primary, Erozenci, Leyla A., primary, Vasile, Enrico, primary, Leon, Leticia G., primary, Pollina, Luca E., primary, Groen, Annemieke, primary, Falcone, Alfredo, primary, Danesi, Romano, primary, Campani, Daniela, primary, Verheul, Henk M., primary, and Boggi, Ugo, primary

Published
2023
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28. Supplementary Figure Legend from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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29. Supplementary Figure 5 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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30. Supplementary Video 1 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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31. Supplementary Figure 2 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Author

Avan, Amir, primary, Caretti, Viola, primary, Funel, Niccola, primary, Galvani, Elena, primary, Maftouh, Mina, primary, Honeywell, Richard J., primary, Lagerweij, Tonny, primary, Van Tellingen, Olaf, primary, Campani, Daniela, primary, Fuchs, Dieter, primary, Verheul, Henk M., primary, Schuurhuis, Gerrit-Jan, primary, Boggi, Ugo, primary, Peters, Godefridus J., primary, Würdinger, Thomas, primary, and Giovannetti, Elisa, primary

Published
2023
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33. Robotic-assisted versus open left pancreatectomy for cystic tumours: A single-centre experience

Author

Morelli, Luca, Di Franco, Gregorio, Guadagni, Simone, Palmeri, Matteo, Furbetta, Niccolò, Funel, Niccola, Gianardi, DesiréE, Palma, Andrea, Pollina, Luca, Moglia, Andrea, Pietrabissa, Andrea, Candio, Giulio, Mosca, Franco, and Cuschieri, Alfred

Subjects
Pancreatectomy, Surgery, Tumors, Comparative literature, Robots, Operating systems (Software), Health
Abstract

Byline: Luca. Morelli, Gregorio. Di Franco, Simone. Guadagni, Matteo. Palmeri, Niccolò. Furbetta, Niccola. Funel, Desirée. Gianardi, Andrea. Palma, Luca. Pollina, Andrea. Moglia, Andrea. Pietrabissa, Giulio. Candio, Franco. Mosca, Alfred. Cuschieri [...]

Published
2020

34. Dysregulated insulin secretion is associated with pancreatic β‐cell hyperplasia and direct acinar‐β‐cell trans‐differentiation in partially eNOS ‐deficient mice

Author

Novelli, Michela, primary, Masini, Matilde, additional, Vecoli, Cecilia, additional, Moscato, Stefania, additional, Funel, Niccola, additional, Pippa, Anna, additional, Mattii, Letizia, additional, Ippolito, Chiara, additional, Campani, Daniela, additional, Neglia, Danilo, additional, and Masiello, Pellegrino, additional

Published
2022
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35. Italian consensus guidelines for the diagnostic work-up and follow-up of cystic pancreatic neoplasms

Author

Albarello, Luca, Camellini, Lorenzo, Cantù, Paolo, Conigliaro, Rita, Costamagna, Guido, Del Favero, Giuseppe, Del Vecchio Blanco, Giovanna, Di Sebastiano, Pierluigi, Fabbri, Carlo, Federici, Paolo, Funel, Niccola, Galli, Andrea, Gabbrielli, Armando, Graziani, Rossella, Guadagnini, Tiziana, Laghi, Andrea, Macarri, Giampiero, Magnolfi, Fabrizio, Marzioni, Marco, Monica, Fabio, Muscatiello, Nicola, Mutignani, Massimiliano, Pisani, Antonio, Scarano, Enrico, Serra, Carla, Spada, Marco, Visconti, Marco, Zambelli, Alessandro, Buscarini, Elisabetta, Pezzilli, Raffaele, Cannizzaro, Renato, Angelis, Claudio De, Gion, Massimo, Morana, Giovanni, Zamboni, Giuseppe, Arcidiacono, Paolo, Balzano, Gianpaolo, Barresi, Luca, Basso, Daniela, Bocus, Paolo, Calculli, Lucia, Capurso, Gabriele, Canzonieri, Vincenzo, Casadei, Riccardo, Crippa, Stefano, D’Onofrio, Mirko, Frulloni, Luca, Fusaroli, Pietro, Manfredi, Guido, Pacchioni, Donatella, Pasquali, Claudio, Rocca, Rodolfo, Ventrucci, Maurizio, Venturini, Silvia, Villanacci, Vincenzo, Zerbi, Alessandro, and Falconi, Massimo

Published
2014
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36. Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms

Author

Obazee, Ofure, Capurso, Gabriele, Tavano, Francesca, Archibugi, Livia, De Bonis, Antonio, Greenhalf, William, Key, Tim, Pasquali, Claudio, Milanetto, Anna Caterina, Hackert, Thilo, Fogar, Paola, Liço, Valbona, Dervenis, Christos, Lawlor, Rita T, Landoni, Luca, Gazouli, Maria, Zambon, Carlo Federico, Funel, Niccola, Strobel, Oliver, Jamroziak, Krzysztof, Cantù, Cinzia, Małecka-Panas, Ewa, Landi, Stefano, Neoptolemos, John P, Basso, Daniela, Talar-Wojnarowska, Renata, Rinzivillo, Maria, Andriulli, Angelo, Canzian, Federico, and Campa, Daniele

Published
2018
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38. Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium

Author

Campa, Daniele, Rizzato, Cosmeri, Capurso, Gabriele, Giese, Nathalia, Funel, Niccola, Greenhalf, William, Soucek, Pavel, Gazouli, Maria, Pezzilli, Raffaele, Pasquali, Claudio, Talar-Wojnarowska, Renata, Cantore, Maurizio, Andriulli, Angelo, Scarpa, Aldo, Jamroziak, Krzysztof, Fave, Gianfranco Delle, Costello, Eithne, Khaw, Kay-Tee, Heller, Anette, Key, Tim J., Theodoropoulos, George, Malecka-Panas, Ewa, Mambrini, Andrea, Bambi, Franco, Landi, Stefano, Pedrazzoli, Sergio, Bassi, Claudio, Pacetti, Paola, Piepoli, Ada, Tavano, Francesca, di Sebastiano, Pierluigi, Vodickova, Ludmila, Basso, Daniela, Plebani, Mario, Fogar, Paola, Büchler, Markus W., Bugert, Peter, Vodicka, Pavel, Boggi, Ugo, Neoptolemos, John P., Werner, Jens, and Canzian, Federico

Published
2013
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41. Genetic Polymorphisms Involved in Mitochondrial Metabolism and Pancreatic Cancer Risk

Author

Peduzzi, Giulia, primary, Gentiluomo, Manuel, additional, Tavano, Francesca, additional, Arcidiacono, Paolo Giorgio, additional, Ermini, Stefano, additional, Vodicka, Pavel, additional, Boggi, Ugo, additional, Cavestro, Giulia Martina, additional, Capurso, Gabriele, additional, Morelli, Luca, additional, Milanetto, Anna Caterina, additional, Pezzilli, Raffaele, additional, Lawlor, Rita T., additional, Carrara, Silvia, additional, Lovecek, Martin, additional, Souček, Pavel, additional, Guo, Feng, additional, Hackert, Thilo, additional, Uzunoğlu, Faik G., additional, Gazouli, Maria, additional, Párniczky, Andrea, additional, Kupcinskas, Juozas, additional, Bijlsma, Maarten F., additional, Bueno-de-Mesquita, Bas, additional, Vermeulen, Roel, additional, van Eijck, Casper H.J., additional, Jamroziak, Krzysztof, additional, Talar-Wojnarowska, Renata, additional, Greenhalf, William, additional, Gioffreda, Domenica, additional, Petrone, Maria C., additional, Landi, Stefano, additional, Archibugi, Livia, additional, Puzzono, Marta, additional, Funel, Niccola, additional, Sperti, Cosimo, additional, Piredda, Maria L., additional, Mohelnikova-Duchonova, Beatrice, additional, Lu, Ye, additional, Hlaváč, Viktor, additional, Gao, Xin, additional, Schneider, Martin, additional, Izbicki, Jakob R., additional, Theodoropoulos, George, additional, Bunduc, Stefania, additional, Kreivenaite, Edita, additional, Busch, Olivier R., additional, Małecka-Panas, Ewa, additional, Costello, Eithne, additional, Perri, Francesco, additional, Testoni, Sabrina Gloria Giulia, additional, Vanella, Giuseppe, additional, Pasquali, Claudio, additional, Oliverius, Martin, additional, Brenner, Hermann, additional, Loos, Martin, additional, Götz, Mara, additional, Georgiou, Konstantinos, additional, Erőss, Bálint, additional, Maiello, Evaristo, additional, Szentesi, Andrea, additional, Bazzocchi, Francesca, additional, Basso, Daniela, additional, Neoptolemos, John P., additional, Hegyi, Péter, additional, Kiudelis, Vytautas, additional, Canzian, Federico, additional, and Campa, Daniele, additional

Published
2021
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42. Detailing the ultrastructure’s increase of prion protein in pancreatic adenocarcinoma

Author

Bianchini, Matteo, primary, Giambelluca, Maria Anita, additional, Scavuzzo, Maria Concetta, additional, Di Franco, Gregorio, additional, Guadagni, Simone, additional, Palmeri, Matteo, additional, Furbetta, Niccolò, additional, Gianardi, Desirée, additional, Funel, Niccola, additional, Ricci, Claudio, additional, Gaeta, Raffaele, additional, Pollina, Luca Emanuele, additional, Falcone, Alfredo, additional, Vivaldi, Caterina, additional, Di Candio, Giulio, additional, Biagioni, Francesca, additional, Busceti, Carla Letizia, additional, Morelli, Luca, additional, and Fornai, Francesco, additional

Published
2021
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43. TERT gene harbors multiple variants associated with pancreatic cancer susceptibility

Author

Campa, Daniele, Rizzato, Cosmeri, Stolzenberg-Solomon, Rachael, Pacetti, Paola, Vodicka, Pavel, Cleary, Sean P., Capurso, Gabriele, Bueno-de-Mesquita, H. B(as), Werner, Jens, Gazouli, Maria, Butterbach, Katja, Ivanauskas, Audrius, Giese, Nathalia, Petersen, Gloria M., Fogar, Paola, Wang, Zhaoming, Bassi, Claudio, Ryska, Miroslav, Theodoropoulos, George E., Kooperberg, Charles, Li, Donghui, Greenhalf, William, Pasquali, Claudio, Hackert, Thilo, Fuchs, Charles S., Mohelnikova-Duchonova, Beatrice, Sperti, Cosimo, Funel, Niccola, Dieffenbach, Aida Karina, Wareham, Nicholas J., Buring, Julie, Holcátová, Ivana, Costello, Eithne, Zambon, Carlo-Federico, Kupcinskas, Juozas, Risch, Harvey A., Kraft, Peter, Bracci, Paige M., Pezzilli, Raffaele, Olson, Sara H., Sesso, Howard D., Hartge, Patricia, Strobel, Oliver, Małecka-Panas, Ewa, Visvanathan, Kala, Arslan, Alan A., Pedrazzoli, Sergio, Souček, Pavel, Gioffreda, Domenica, Key, Timothy J., Talar-Wojnarowska, Renata, Scarpa, Aldo, Mambrini, Andrea, Jacobs, Eric J., Jamroziak, Krzysztof, Klein, Alison, Tavano, Francesca, Bambi, Franco, Landi, Stefano, Austin, Melissa A., Vodickova, Ludmila, Brenner, Hermann, Chanock, Stephen J., Fave, Gianfranco Delle, Piepoli, Ada, Cantore, Maurizio, Zheng, Wei, Wolpin, Brian M., Amundadottir, Laufey T., and Canzian, Federico

Published
2015
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46. Silver Nanoparticle-Coated Polyhydroxyalkanoate Based Electrospun Fibers for Wound Dressing Applications

Author

Kalaoglu-Altan, Ozlem Ipek, primary, Baskan, Havva, additional, Meireman, Timo, additional, Basnett, Pooja, additional, Azimi, Bahareh, additional, Fusco, Alessandra, additional, Funel, Niccola, additional, Donnarumma, Giovanna, additional, Lazzeri, Andrea, additional, Roy, Ipsita, additional, Danti, Serena, additional, and De Clerck, Karen, additional

Published
2021
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47. Zebrafish Patient-Derived Xenografts Identify Chemo-Response in Pancreatic Ductal Adenocarcinoma Patients

Author

Usai, Alice, primary, Di Franco, Gregorio, additional, Piccardi, Margherita, additional, Cateni, Perla, additional, Pollina, Luca Emanuele, additional, Vivaldi, Caterina, additional, Vasile, Enrico, additional, Funel, Niccola, additional, Palmeri, Matteo, additional, Dente, Luciana, additional, Falcone, Alfredo, additional, Giunchi, Dimitri, additional, Massolo, Alessandro, additional, Raffa, Vittoria, additional, and Morelli, Luca, additional

Published
2021
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48. Genetic Polymorphisms Involved in Mitochondrial Metabolism and Pancreatic Cancer Risk

Author

Peduzzi, Giulia Gentiluomo, Manuel Tavano, Francesca and Arcidiacono, Paolo Giorgio Ermini, Stefano Vodicka, Pavel and Boggi, Ugo Cavestro, Giulia Martina Capurso, Gabriele and Morelli, Luca Milanetto, Anna Caterina Pezzilli, Raffaele and Lawlor, Rita T. Carrara, Silvia Lovecek, Martin Souc, Pavel and Guo, Feng Hackert, Thilo Uzunoglu, Faik G. Gazouli, Maria Parniczky, Andrea Kupcinskas, Juozas Bijlsma, Maarten F. Bueno-de-Mesquita, Bas Vermeulen, Roel van Eijck, Casper H. J. Jamroziak, Krzysztof Talar-Wojnarowska, Renata and Greenhalf, William Gioffreda, Domenica Petrone, Maria C. and Landi, Stefano Archibugi, Livia Puzzono, Marta Funel, Niccola Sperti, Cosimo Piredda, Maria L. and Mohelnikova-Duchonova, Beatrice Lu, Ye Hlavac, Viktor Gao, Xin Schneider, Martin Izbicki, Jakob R. Theodoropoulos, George Bunduc, Stefania Kreivenaite, Edita Busch, Olivier R. and Malecka-Panas, Ewa Costello, Eithne Perri, Francesco and Testoni, Sabrina Gloria Giulia Vanella, Giuseppe Pasquali, Claudio Oliverius, Martin Brenner, Hermann Loos, Martin and Gotz, Mara Georgiou, Konstantinos Eross, Alint Maiello, Evaristo Szentesi, Andrea Bazzocchi, Francesca Basso, Daniela Neoptolemos, John P. Hegyi, P. Eter Kiudelis, Vytautas Canzian, Federico Campa, Daniele

Subjects
endocrine system diseases
Abstract

Background: The mitochondrial metabolism has been associated with pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also suggests the involvement of the genetic variability of the mitochondrial function in several traits involved in PDAC etiology. However, a systematic investigation of the genetic variability of mitochondrial genome (mtSNP) and of all the nuclear genes involved in its functioning (n-mtSNPs) has never been reported. Methods: We conducted a two-phase association study of mtSNPs and n-mtSNPs to assess their effect on PDAC risk. We analyzed 35,297 n-mtSNPs and 101 mtSNPs in up to 55,870 individuals (12,884 PDAC cases and 42,986 controls). In addition, we also conducted a gene-based analysis on 1,588 genes involved in mitochondrial metabolism using Multi-marker Analysis of GenoMic Annotation (MAGMA) software. Results: In the discovery phase, we identified 49 n-mtSNPs and no mtSNPs associated with PDAC risk (P < 0.05). In the second phase, none of the findings were replicated. In the gene-level analysis, we observed that three genes (TERT, SUGCT, and SURF1) involved in the mitochondrial metabolism showed an association below the Bonferroni-corrected threshold of statistical significance (P = 0.05/1588 - 3.1 x 10(-5)). Conclusions: Even though the mitochondrial metabolism might be involved in PDAC etiology, our results, obtained in a study with one of the largest sample sizes to date, show that neither n-mtSNPs nor mtSNPs are associated with PDAC risk.

Published
2021

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