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4. Multivalent glycoconjugates as anti-pathogenic agents

Author

Bernardi, Anna, Jimenez-Barbero, Jesus, Casnati, Alessandro, De Castro, Cristina, Darbre, Tamis, Fieschi, Franck, Finne, Jukka, Funken, Horst, Jaeger, Karl-Erich, Lahmann, Martina, Lindhorst, Thisbe K., Marradi, Marco, Messner, Paul, Molinaro, Antonio, Murphy, Paul V., Nativi, Cristina, Oscarson, Stefan, Penades, Soledad, Peri, Francesco, Pieters, Roland J., Renaudet, Olivier, Reymond, Jean-Louis, Richichi, Barbara, Rojo, Javier, Sansone, Francesco, Schaeffer, Christina, Turnbull, W. Bruce, Velasco-Torrijos, Trinidad, Vidal, Sebastien, Vincent, Stephane, Wennekes, Tom, Zuilhof, Han, Imberty, Anne, Bernardi, Anna, Jimenez-Barbero, Jesus, Casnati, Alessandro, De Castro, Cristina, Darbre, Tamis, Fieschi, Franck, Finne, Jukka, Funken, Horst, Jaeger, Karl-Erich, Lahmann, Martina, Lindhorst, Thisbe K., Marradi, Marco, Messner, Paul, Molinaro, Antonio, Murphy, Paul V., Nativi, Cristina, Oscarson, Stefan, Penades, Soledad, Peri, Francesco, Pieters, Roland J., Renaudet, Olivier, Reymond, Jean-Louis, Richichi, Barbara, Rojo, Javier, Sansone, Francesco, Schaeffer, Christina, Turnbull, W. Bruce, Velasco-Torrijos, Trinidad, Vidal, Sebastien, Vincent, Stephane, Wennekes, Tom, Zuilhof, Han, and Imberty, Anne

Abstract

Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies., QC 20211206

Published
2013
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5. Multivalent glycoconjugates as anti-pathogenic agents

Author

Bernardi, Anna, Jimenez-Barbero, Jesus, Casnati, Alessandro, De Castro, Christina, Darbre, Tamis, Fieschi, Franck, Finne, Jukka, Funken, Horst, Jaeger, Karl-Erich, Lahmann, Martina, Lindhorst, Thisbe K., Marradi, Marco, Messner, Paul, Molinaro, Antonio, Murphy, Paul V., Nativi, Cristina, Oscarson, Stefan, Penades, Soledad, Peri, Francesco, Pieters, Roland J., Renaudet, Olivier, Reymond, Jean-Reymond, Richichi, Barbara, Rojo, Javier, Sansone, Francesco, Schaffer, Christina, Turnbull, W. Bruce, Velasco-Torrijos, Trinidad, Vidal, Sebastien, Vincent, Stephane, Wennekes, Tom, Zuilhof, Han, Imberty, Anne, Bernardi, Anna, Jimenez-Barbero, Jesus, Casnati, Alessandro, De Castro, Christina, Darbre, Tamis, Fieschi, Franck, Finne, Jukka, Funken, Horst, Jaeger, Karl-Erich, Lahmann, Martina, Lindhorst, Thisbe K., Marradi, Marco, Messner, Paul, Molinaro, Antonio, Murphy, Paul V., Nativi, Cristina, Oscarson, Stefan, Penades, Soledad, Peri, Francesco, Pieters, Roland J., Renaudet, Olivier, Reymond, Jean-Reymond, Richichi, Barbara, Rojo, Javier, Sansone, Francesco, Schaffer, Christina, Turnbull, W. Bruce, Velasco-Torrijos, Trinidad, Vidal, Sebastien, Vincent, Stephane, Wennekes, Tom, Zuilhof, Han, and Imberty, Anne

Abstract

Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein–glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies

Published
2012

7. Multivalent glycoconjugates as anti-pathogenic agents

Author

Bernardi, Anna, primary, Jiménez-Barbero, Jesus, additional, Casnati, Alessandro, additional, De Castro, Cristina, additional, Darbre, Tamis, additional, Fieschi, Franck, additional, Finne, Jukka, additional, Funken, Horst, additional, Jaeger, Karl-Erich, additional, Lahmann, Martina, additional, Lindhorst, Thisbe K., additional, Marradi, Marco, additional, Messner, Paul, additional, Molinaro, Antonio, additional, Murphy, Paul V., additional, Nativi, Cristina, additional, Oscarson, Stefan, additional, Penadés, Soledad, additional, Peri, Francesco, additional, Pieters, Roland J., additional, Renaudet, Olivier, additional, Reymond, Jean-Louis, additional, Richichi, Barbara, additional, Rojo, Javier, additional, Sansone, Francesco, additional, Schäffer, Christina, additional, Turnbull, W. Bruce, additional, Velasco-Torrijos, Trinidad, additional, Vidal, Sébastien, additional, Vincent, Stéphane, additional, Wennekes, Tom, additional, Zuilhof, Han, additional, and Imberty, Anne, additional

Published
2013
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10. The Lipase LipA (PA2862) but Not LipC (PA4813) from Pseudomonas aeruginosa Influences Regulation of Pyoverdine Production and Expression of the Sigma Factor PvdS.

Author

Funken, Horst, Knapp, Andreas, Vasil, Michael L., Wilhelm, Susanne, Jaeger, Karl-Erich, and Rosenau, Frank

Subjects
*IRON metabolism, *PSEUDOMONAS aeruginosa, *MICROBIAL virulence, *SIDEROPHORES, *MICROBIAL metabolites, *LIPASES
Abstract

A key element in iron-dependent regulation of iron metabolism and virulence-related functions for Pseudomonas aeruginosa is the sigma factor PvdS. PvdS expression itself is also influenced by iron-independent stimuli. We show that pyoverdine production and pvdS expression depend on one of the two lipases of P. aeruginosa. [ABSTRACT FROM AUTHOR]

Published
2011
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11. Subtilase SprP exerts pleiotropic effects in Pseudomonas aeruginosa.

Author

Pelzer A, Polen T, Funken H, Rosenau F, Wilhelm S, Bott M, and Jaeger KE

Subjects
Anaerobiosis, Bacterial Proteins genetics, Biofilms, Cloning, Molecular, DNA, Bacterial genetics, DNA, Recombinant genetics, Denitrification, Escherichia coli, Gene Deletion, Oligopeptides biosynthesis, Open Reading Frames, Protein Structure, Tertiary, Pseudomonas aeruginosa genetics, Pseudomonas aeruginosa growth & development, Pseudomonas aeruginosa pathogenicity, RNA, Bacterial biosynthesis, RNA, Messenger biosynthesis, Recombinant Fusion Proteins metabolism, Subtilisins genetics, Virulence, Bacterial Proteins physiology, Genes, Bacterial, Genetic Pleiotropy, Pseudomonas aeruginosa enzymology, Subtilisins physiology
Abstract

The open reading frame PA1242 in the genome of Pseudomonas aeruginosa PAO1 encodes a putative protease belonging to the peptidase S8 family of subtilases. The respective enzyme termed SprP consists of an N-terminal signal peptide and a so-called S8 domain linked by a domain of unknown function (DUF). Presumably, this DUF domain defines a discrete class of Pseudomonas proteins as homologous domains can be identified almost exclusively in proteins of the genus Pseudomonas. The sprP gene was expressed in Escherichia coli and proteolytic activity was demonstrated. A P. aeruginosa ∆sprP mutant was constructed and its gene expression pattern compared to the wild-type strain by genome microarray analysis revealing altered expression levels of 218 genes. Apparently, SprP is involved in regulation of a variety of different cellular processes in P. aeruginosa including pyoverdine synthesis, denitrification, the formation of cell aggregates, and of biofilms., (© 2013 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.)

Published
2014
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