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393 results on '"Furihata M"'

3. Severe combined immunodeficiency disease

Author

Militsakh, O., Day, T., Hornig, J., Lentsch, E., Skoner, J., Gillespie, M., Sharma, A., Neville, B., Rumboldt, Z., James, R., Goddard, J., Shikata, K., Doi, Y., Rosen, E. M., Goldberg, I. D., Fan, S., Kong, L., Lu, J. J., Chlenski, A., Cohn, S. L., Hlubek, F., Qian, C.-N., Teh, B. T., Batistatou, A., Charalbopoulos, K., Christensen, C., Reddel, R., Ploeg, I. M. C., Kroon, B. B. R., Nieweg, O. E., Rijk, M. C., Winqvist, O., Thorn, M., Zwick, C., Pfreundschuh, M., Knudsen, B. S., Lucas, J., Nelson, P., Kashikar, N., Datta, P. K., Hottinger, A. F., Hormigo, A., Knobler, E., Knobler, R., McCarty, J. H., Bardia, A., Loprinzi, C., Buettner, R., Jove, R., Garcia, R., Frank, D. A., Nakatsura, T., Witt, O., Yoshida, K., Chou, P.-L., Tsay, G. J., Takeuchi, T., Furihata, M., Robertson, F. M., Werbowetski-Ogilvie, T. E., Maestro, R. F., Sadr, M. S., Dennler, S., Dijke, P., Gadgeel, S., Tierauch, K.-H., Yip, K. W., Liu, F.-F., Cano, A., Neto, M. A., Rünger, T. M., Frühwald, Michael C., Trakhtenbrot, L., Mi, J., Larner, J. M., Hamlin, J. L., Radin, N. S., Lo, T. L., Guy, G. R., Yeudall, W. A., Parsons, S. J., Fan, F., Platanias, L. C., Mcgahren-Murray, M., Keyomarsi, K., Kos, J., Seigel, G. M., Alison, M. R., Hiyama, E., Renehan, A. G., Potten, C. S., Tang, D. G., Foster, P., Lin, K., Bergelt, C., Ronai, Z., Cukierman, E., Aumercier, M., Hodson, M., Lolis, E., Mehta, A., Chung, F.-L., Glatt, H., Oberthür, A., Warnat, P., Aranda, S., Culig, Z., Chung, B. H., Shin, Y.-B., Kim, M., Grevenstein, W. M. U., van Eijck, C. H. J., Baker, S. G., Kramer, B. S., Mahotka, C., Carbone, M., Yang, H., Mueller, S. C., Coopman, P. J., Brujin, D., Kessel, A. D., and George, J. M.

Published
2020

4. Squamous cell carcinoma

Author

Yeudall, W. A., Militsakh, O., Day, T., Hornig, J., Lentsch, E., Skoner, J., Gillespie, M., Sharma, A., Neville, B., Rumboldt, Z., James, R., Goddard, J., Shikata, K., Doi, Y., Rosen, E. M., Goldberg, I. D., Fan, S., Kong, L., Lu, J. J., Chlenski, A., Cohn, S. L., Hlubek, F., Qian, C.-N., T., B. T., Batistatou, A., Charalbopoulos, K., Christensen, C., Reddel, R., Ploeg, I. M. C., Kroon, B. B. R., Nieweg, O. E., Rijk, M. C., Winqvist, O., Thorn, M., Zwick, C., Pfreundschuh, M., Knudsen, B. S., Lucas, J., Nelson, P., Kashikar, N., Datta, P. K., Hottinger, A. F., Hormigo, A., Knobler, E., Knobler, R., McCarty, J. H., Bardia, A., Loprinzi, C., Buettner, R., Jove, R., Garcia, R., Frank, D. A., Nakatsura, T., Witt, O., Yoshida, K., Chou, P.-L., Tsay, G. J., Takeuchi, T., Furihata, M., Robertson, F. M., Werbowetski-Ogilvie, T. E., Maestro, R. F., Sadr, M. S., Dennler, S., Dijke, P., Gadgeel, S., Tierauch, K.-H., Yip, K. W., Liu, F.-F., Cano, A., Neto, M. A., Rünger, T. M., Frühwald, Michael C., Trakhtenbrot, L., Mi, J., Larner, J. M., Hamlin, J. L., Radin, N. S., Lo, T. L., Guy, G. R., Parsons, S. J., Fan, F., Platanias, L. C., Mcgahren-Murray, M., Keyomarsi, K., Kos, J., Seigel, G. M., Alison, M. R., Hiyama, E., Renehan, A.G., Potten, C. S., Tang, D. G., Foster, P., Lin, K., Bergelt, C., Ronai, Z., Cukierman, E., Aumercier, M., Hodson, M., Lolis, E., Mehta, A., Chung, F.-L., Glatt, H., Oberthür, A., Warnat, P., Aranda, S., Culig, Z., Chung, B. H., Shin, Y.-B., Kim, M., Grevenstein, W. M. U., van Eijck, C. H. J., Baker, S. G., Kramer, B. S., Mahotka, C., Carbone, M., Yang, H., Mueller, S. C., Coopman, P. J., Brujin, D., Kessel, A. D., and George, J. M.

Published
2020

20. 434 Four loci at 11q12, 10q26, 3p11.2, and 2p11 are associated with prostate cancer susceptibility in the Japanese population

Author

Akamatsu, S., primary, Takata, R., additional, Haiman, C.A., additional, Inoue, T., additional, Takahashi, A., additional, Kubo, M., additional, Furihata, M., additional, Kamatani, N., additional, Inazawa, J., additional, Chen, G.K., additional, Marchand, L.L., additional, Kolonel, L.N., additional, Yamada, H., additional, Egawa, S., additional, Fujioka, T., additional, Henderson, B.E., additional, Habuchi, T., additional, Ogawa, O., additional, Nakamura, Y., additional, and Nakagawa, H., additional

Published
2012
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23. Kidney-Targeted Birt-Hogg-Dube Gene Inactivation in a Mouse Model: Erk1/2 and Akt-mTOR Activation, Cell Hyperproliferation, and Polycystic Kidneys

Author

Baba, M., primary, Furihata, M., additional, Hong, S.-B., additional, Tessarollo, L., additional, Haines, D. C., additional, Southon, E., additional, Patel, V., additional, Igarashi, P., additional, Alvord, W. G., additional, Leighty, R., additional, Yao, M., additional, Bernardo, M., additional, Ileva, L., additional, Choyke, P., additional, Warren, M. B., additional, Zbar, B., additional, Linehan, W. M., additional, and Schmidt, L. S., additional

Published
2008
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46. Reduced human mismatch repair protein expression in the development of precancerous skin lesions to squamous cell carcinoma.

Author

Liang, Sheng-Ben, Furihata, Mutsuo, Takeuchi, Tamotsu, Sonobe, Hiroshi, Ohtsuki, Yuji, Liang, S B, Furihata, M, Takeuchi, T, Sonobe, H, and Ohtsuki, Y

Abstract

Loss of human mismatch repair (hMSH2) gene function has been linked to hereditary non-polyposis colorectal cancer (HNPCC), Muir-Torre syndrome (MTS), and sporadic cancers, excluding skin cancers unrelated to MTS. We immunohistochemically examined 125 squamous cell carcinomas (SCCs) using a monoclonal antibody to the hMSH2 protein and compared the results with those for 106 precursor lesions of SCC, consisting of actinic keratosis (AK), Bowenoid type of actinic keratosis (BAK), and Bowen's disease (BOD). In contrast to the homogeneous immunoreactivity of proliferating cells composed of AK, BAK, and BOD, heterogeneous and diminished immunostaining to hMSH2 was observed in tumor cells of SCCs examined. In addition, two SCCs (2 of 125; 1.6%) at multiple loci exhibited a complete lack of immunoreaction to hMSH2. Immunohistochemical staining of hMSH2 was semiquantitatively scored as 0 (0% of total cells examined), 1 (less than 10%), 2 (10-50%), or 3 (more than 50%). Percentage preservation of and average score for hMSH2 expression in normal, AK, BAK, BOD, and SCC were 56% and 2.06, 100% and 2.80, 94% and 2.88, 83% and 2.78, 63% and 2.36, respectively. The percentage preservation of and average scores for hMSH2 in AK, BAK, and BOD were significantly higher than those in presumably normal skin (P<0.01). There were no significant differences in the percentage preservation of and average scores for hMSH2 between presumably normal skin and SCC. The score for hMSH2 expression was significantly correlated with score for sun exposure in presumably normal skin of each lesion (R=0.70). These findings for hMSH2 expression in precursor lesions and SCC suggest that promotion or activation of hMSH2 expression may be induced by the increased DNA damage caused by sun exposure and that diminished expression of it might occur according to the transformation from precancerous lesions to SCC. [ABSTRACT FROM AUTHOR]

Published
2001
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48. Sun-exposure- and aging-dependent p53 protein accumulation results in growth advantage for tumour cells in carcinogenesis of nonmelanocytic skin cancer.

Author

Liang, Sheng-Ben, Ohtsuki, Y., Furihata, Mutsuo, Takeuchi, Tamotsu, Iwata, J., Chen, Bing-Kun, Sonobe, Hiroshi, Liang, S B, Furihata, M, Takeuchi, T, Chen, B K, and Sonobe, H

Abstract

Three hundred and sixteen patients with nonmelanocytic skin cancer, including 46 cases of Bowen's disease (BOD), 134 cases of squamous cell carcinoma (SCC), and 136 cases of basal cell carcinoma (BCC), were examined immunohistochemically using monoclonal antibody DO-7 to assess p53 protein accumulation related to sun exposure and ageing, and growth and differentiation of skin cancer and its precursors. The rates of p53 immunostaining of BOD, SCC and BCC were 80.4%, 76.1% and 70.6%, respectively. p53-positive cells were present not only in cancer nests, but also in dysplastic and even morphologically normal epidermis adjoining cancers. Sun exposure was statistically correlated with the p53 immunostaining scores in morphologically normal epidermis of the three skin cancers and in cancer nests of SCC and BCC. The positivity and score of p53 protein often differed significantly among the three types of cancer, especially in regions of dysplasia. Interestingly, differentiation of SCC was correlated with individual p53 scores for dysplasia and cancer nests, especially for dysplasia. BOD, as the precursor of SCC, demonstrated the strongest p53 expression. Furthermore, 12.3% cases with p53 negative cancer nests showed p53-positive reaction in dysplasia and in morphologically normal epidermis. It seems that the accumulation of p53 protein plays a part in precancerous lesions and in the genesis of more highly differentiated types of skin cancer and affects mainly the growth of tumour cells rather than their differentiation. For BCC, however, age was significantly related to p53 expression. Our findings suggest that overexpression of p53 in normal skin and cancer nests of SCC and BCC is significantly related to sun exposure, that the expression of p53 in BCC is an age-dependent process, and that the early accumulation of p53 protein may be a useful predictor for the detection of nonmelanocytic skin cancer. [ABSTRACT FROM AUTHOR]

Published
1999
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50. Synthesis and Characterization of Novel Inclusion Complexes between Microporous Molybdenum(II) Dicarboxylates and Organic Polymers

Author

Takamaizawa, S., Furihata, M., Takeda, S., Yamaguchi, K., and Mori, W.

Abstract

Novel inclusion complexes between host microporous molybdenum(II) dicarboxylates (fumarate, terephthalate, trans−trans-muconate, and pyridine-2,5-dicarboxylate) and guest organic polyethers (poly(ethylene glycol) (PEG) and poly(propylene glycol) (PPG)) of various molecular weights were synthesized. The rate of complex formation depends on the shapes of the micropores and polyethers. The amount of included polyethers increased with their molecular weight, and reached a saturated amount, with the exception that molybdenum(II) pyridine-2,5-dicarboxylate did not form complexes with bulky PPG. The amount of adsorbed argon in the microporous molybdenum(II) dicarboxylates decreased with increased amounts of included polyethers. The 13C CP/MAS NMR measurement of molybdenum(II) terephthalate with PEG demonstrated that PEG chains are included in the capillaries. This is an effective method for synthesizing supramolecular complexes.

Published
2000

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