Search

Your search keyword '"Fusco A"' showing total 54,137 results
Start Over Author "Fusco A"
54,137 results on '"Fusco A"'

1. Consistency for the surface diffusion flat flow in three dimensions

Author

Cicalese, Marco, Fusco, Nicola, Julin, Vesa, and Kubin, Andrea

Subjects
Mathematics - Analysis of PDEs
Abstract

We investigate the flat flow solution for the surface diffusion equation via the discrete minimizing movements scheme proposed by Cahn and Taylor. We prove that in dimension three the scheme converges to the unique smooth solution of the equation, provided that the initial set is sufficiently regular.

Published
2025

2. A deep learning framework for efficient pathology image analysis

Author

Neidlinger, Peter, Lenz, Tim, Foersch, Sebastian, Loeffler, Chiara M. L., Clusmann, Jan, Gustav, Marco, Shaktah, Lawrence A., Langer, Rupert, Dislich, Bastian, Boardman, Lisa A., French, Amy J., Goode, Ellen L., Gsur, Andrea, Brezina, Stefanie, Gunter, Marc J., Steinfelder, Robert, Behrens, Hans-Michael, Röcken, Christoph, Harrison, Tabitha, Peters, Ulrike, Phipps, Amanda I., Curigliano, Giuseppe, Fusco, Nicola, Marra, Antonio, Hoffmeister, Michael, Brenner, Hermann, and Kather, Jakob Nikolas

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Artificial intelligence (AI) has transformed digital pathology by enabling biomarker prediction from high-resolution whole slide images (WSIs). However, current methods are computationally inefficient, processing thousands of redundant tiles per WSI and requiring complex aggregator models. We introduce EAGLE (Efficient Approach for Guided Local Examination), a deep learning framework that emulates pathologists by selectively analyzing informative regions. EAGLE incorporates two foundation models: CHIEF for efficient tile selection and Virchow2 for extracting high-quality features. Benchmarking was conducted against leading slide- and tile-level foundation models across 31 tasks from four cancer types, spanning morphology, biomarker prediction and prognosis. EAGLE outperformed state-of-the-art foundation models by up to 23% and achieved the highest AUROC overall. It processed a slide in 2.27 seconds, reducing computational time by more than 99% compared to existing models. This efficiency enables real-time workflows, allows pathologists to validate all tiles which are used by the model during analysis, and eliminates dependence on high-performance computing, making AI-powered pathology more accessible. By reliably identifying meaningful regions and minimizing artifacts, EAGLE provides robust and interpretable outputs, supporting rapid slide searches, integration into multi-omics pipelines and emerging clinical foundation models.

Published
2025

3. KM3NeT Constraint on Lorentz-Violating Superluminal Neutrino Velocity

Author

KM3NeT Collaboration, Adriani, O., Aiello, S., Albert, A., Alhebsi, A. R., Alshamsi, M., Garre, S. Alves, Ambrosone, A., Ameli, F., Andre, M., Aphecetche, L., Ardid, M., Ardid, S., Argüelles, C., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardačová, Z., Baret, B., Bariego-Quintana, A., Becherini, Y., Bendahman, M., Gualandi, F. Benfenati, Benhassi, M., Bennani, M., Benoit, D. M., Berbee, E., Berti, E., Bertin, V., Betti, P., Biagi, S., Boettcher, M., Bonanno, D., Bottai, S., Bouasla, A. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Brânzaş, H., Bretaudeau, F., Breuhaus, M., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carenini, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chen, A., Cherubini, S., Chiarusi, T., Circella, M., Clark, R., Cocimano, R., Coelho, J. A. B., Coleiro, A., Condorelli, A., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Benedittis, A., De Wasseige, G., Decoene, V., Deguire, P., Del Rosso, I., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drakopoulou, E., Drouhin, D., Ducoin, J. -G., Duverne, P., Dvornický, R., Eberl, T., Eckerová, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Mentawi, S. El, Ellajosyula, V., Enzenhöfer, A., Ferrara, G., Filipović, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gagliardini, S., Gal, T., Méndez, J. García, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Genton, E., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Gozzini, S. R., Gracia, R., Guidi, C., Guillon, B., Gutiérrez, M., Haack, C., van Haren, H., Heijboer, A., Hennig, L., Hernández-Rey, J. J., Idrissi, A., Ibnsalih, W. Idrissi, Illuminati, G., Janik, O., Joly, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kamp, N., Keegans, J., Kikvadze, V., Kistauri, G., Kopper, C., Kouchner, A., Kovalev, Y. Y., Krupa, L., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazar, J., Lazo, A., Stum, S. Le, Lehaut, G., Lemaître, V., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Longhitano, F., Magnani, F., Majumdar, J., Malerba, L., Mamedov, F., Manfreda, A., Manousakis, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Mastrodicasa, M., Mastroianni, S., Mauro, J., Mehta, K. C. K., Meskar, A., Miele, G., Migliozzi, P., Migneco, E., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Mori, N., Moussa, A., Mateo, I. Mozun, Muller, R., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, Oliviero, V., Orlando, A., Oukacha, E., Pacini, L., Paesani, D., González, J. Palacios, Papalashvili, G., Papini, P., Parisi, V., Parmar, A., Gomez, E. J. Pastor, Pastore, C., Păun, A. M., Păvălaş, G. E., Martínez, S. Peña, Perrin-Terrin, M., Pestel, V., Pestes, R., Petropavlova, M., Piattelli, P., Plavin, A., Poirè, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quiroz-Rangel, C. A., Randazzo, N., Ratnani, A., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Robinson, J., Romanov, A., Ros, E., Šaina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanfilippo, S., Sanguineti, M., Santonocito, D., Sapienza, P., Scaringella, M., Scarnera, M., Schnabel, J., Schumann, J., Schutte, H. M., Seneca, J., Sennan, N., Myhr, P. A. Sevle, Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Šimkovic, F., Simonelli, A., Sinopoulou, A., Spisso, B., Spurio, M., Starodubtsev, O., Stavropoulos, D., Štekl, I., Stocco, D., Taiuti, M., Takadze, G., Tayalati, Y., Thiersen, H., Thoudam, S., Melo, I. Tosta e, Trocmé, B., Tsourapis, V., Tzamariudaki, E., Ukleja, A., Vacheret, A., Valsecchi, V., Van Elewyck, V., Vannoye, G., Vannuccini, E., Vasileiadis, G., de Sola, F. Vazquez, Veutro, A., Viola, S., Vivolo, D., van Vliet, A., Wen, A. Y., de Wolf, E., Lhenry-Yvon, I., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Lorentz invariance is a fundamental symmetry of spacetime and foundational to modern physics. One of its most important consequences is the constancy of the speed of light. This invariance, together with the geometry of spacetime, implies that no particle can move faster than the speed of light. In this article, we present the most stringent neutrino-based test of this prediction, using the highest energy neutrino ever detected to date, KM3-230213A. The arrival of this event, with an energy of $220^{+570}_{-110}\,\text{PeV}$, sets a constraint on $\delta \equiv c_\nu^2-1 < 4\times10^{-22}$.

Published
2025

4. The ultra-high-energy event KM3-230213A within the global neutrino landscape

Author

KM3NeT Collaboration, Adriani, O., Aiello, S., Albert, A., Alhebsi, A. R., Alshamsi, M., Garre, S. Alves, Ambrosone, A., Ameli, F., Andre, M., Aphecetche, L., Ardid, M., Ardid, S., Argüelles, C., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardačová, Z., Baret, B., Bariego-Quintana, A., Becherini, Y., Bendahman, M., Gualandi, F. Benfenati, Benhassi, M., Bennani, M., Benoit, D. M., Berbee, E., Berti, E., Bertin, V., Betti, P., Biagi, S., Boettcher, M., Bonanno, D., Bottai, S., Bouasla, A. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Brânzaš, H., Bretaudeau, F., Breuhaus, M., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carenini, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chen, A., Cherubini, S., Chiarusi, T., Circella, M., Clark, R., Cocimano, R., Coelho, J. A. B., Coleiro, A., Condorelli, A., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Benedittis, A., De Wasseige, G., Decoene, V., Deguire, P., Del Rosso, I., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drakopoulou, E., Drouhin, D., Ducoin, J. -G., Duverne, P., Dvornický, R., Eberl, T., Eckerová, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Mentawi, S. El, Ellajosyula, V., Enzenhöfer, A., Ferrara, G., Filipović, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gal, T., Méndez, J. García, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Genton, E., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Gozzini, S. R., Gracia, R., Guidi, C., Guillon, B., Gutiérrez, M., Haack, C., van Haren, H., Heijboer, A., Hennig, L., Hernández-Rey, J. J., Idrissi, A., Ibnsalih, W. Idrissi, Illuminati, G., Janik, O., Joly, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kamp, N., Keegans, J., Kikvadze, V., Kistauri, G., Kopper, C., Kouchner, A., Kovalev, Y. Y., Krupa, L., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazar, J., Lazo, A., Stum, S. Le, Lehaut, G., Lemaître, V., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Longhitano, F., Magnani, F., Majumdar, J., Malerba, L., Mamedov, F., Manfreda, A., Manousakis, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Mastrodicasa, M., Mastroianni, S., Mauro, J., Mehta, K. C. K., Meskar, A., Miele, G., Migliozzi, P., Migneco, E., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Mori, N., Moussa, A., Mateo, I. Mozun, Muller, R., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, Oliviero, V., Orlando, A., Oukacha, E., Pacini, L., Paesani, D., González, J. Palacios, Papalashvili, G., Papini, P., Parisi, V., Parmar, A., Gomez, E. J. Pastor, Pastore, C., Păun, A. M., Păvălaš, G. E., Martínez, S. Peña, Perrin-Terrin, M., Pestel, V., Pestes, R., Petropavlova, M., Piattelli, P., Plavin, A., Poirè, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quiroz-Rangel, C. A., Randazzo, N., Ratnani, A., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Robinson, J., Romanov, A., Ros, E., Šaina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanfilippo, S., Sanguineti, M., Santonocito, D., Sapienza, P., Scaringella, M., Scarnera, M., Schnabel, J., Schumann, J., Schutte, H. M., Seneca, J., Sennan, N., Myhr, P. A. Sevle, Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Šimkovic, F., Simonelli, A., Sinopoulou, A., Spisso, B., Spurio, M., Starodubtsev, O., Stavropoulos, D., Štekl, I., Stocco, D., Taiuti, M., Takadze, G., Tayalati, Y., Thiersen, H., Thoudam, S., Melo, I. Tosta e, Trocmé, B., Tsourapis, V., Tzamariudaki, E., Ukleja, A., Vacheret, A., Valsecchi, V., Van Elewyck, V., Vannoye, G., Vannuccini, E., Vasileiadis, G., de Sola, F. Vazquez, Veutro, A., Viola, S., Vivolo, D., van Vliet, A., Wen, A. Y., de Wolf, E., Lhenry-Yvon, I., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

On February 13th, 2023, the KM3NeT/ARCA telescope detected a neutrino candidate with an estimated energy in the hundreds of PeVs. In this article, the observation of this ultra-high-energy neutrino is discussed in light of null observations above tens of PeV from the IceCube and Pierre Auger observatories. Performing a joint fit of all experiments under the assumption of an isotropic $E^{-2}$ flux, the best-fit single-flavour flux normalisation is $E^2 \Phi^{\rm 1f}_{\nu + \bar \nu} = 7.5 \times 10^{-10}~{\rm GeV cm^{-2} s^{-1} sr^{-1}}$ in the 90% energy range of the KM3NeT event. Furthermore, the ultra-high-energy data are then fit together with the IceCube measurements at lower energies, either with a single power law or with a broken power law, allowing for the presence of a new component in the spectrum. The joint fit including non-observations by other experiments in the ultra-high-energy region shows a slight preference for a break in the PeV regime if the ``High-Energy Starting Events'' sample is included, and no such preference for the other two IceCube samples investigated. A stronger preference for a break appears if only the KM3NeT data is considered in the ultra-high-energy region, though the flux resulting from such a fit would be inconsistent with null observations from IceCube and Pierre Auger. In all cases, the observed tension between KM3NeT and other datasets is of the order of $2.5\sigma-3\sigma$, and increased statistics are required to resolve this apparent tension and better characterise the neutrino landscape at ultra-high energies., Comment: 11 pages, 4 figures

Published
2025

5. On the Potential Galactic Origin of the Ultra-High-Energy Event KM3-230213A

Author

Adriani, O., Aiello, S., Albert, A., Alhebsi, A. R., Alshamsi, M., Garre, S. Alves, Ambrosone, A., Ameli, F., Andre, M., Aphecetche, L., Ardid, M., Ardid, S., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardačová, Z., Baret, B., Bariego-Quintana, A., Becherini, Y., Bendahman, M., Gualandi, F. Benfenati, Benhassi, M., Bennani, M., Benoit, D. M., Berbee, E., Berti, E., Bertin, V., Betti, P., Biagi, S., Boettcher, M., Bonanno, D., Bottai, S., Bouasla, A. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Brânzaş, H., Bretaudeau, F., Breuhaus, M., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carenini, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chen, A., Cherubini, S., Chiarusi, T., Circella, M., Clark, R., Cocimano, R., Coelho, J. A. B., Coleiro, A., Condorelli, A., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Benedittis, A., De Wasseige, G., Decoene, V., Deguire, P., Del Rosso, I., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drakopoulou, E., Drouhin, D., Ducoin, J. -G., Duverne, P., Dvornický, R., Eberl, T., Eckerová, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Mentawi, S. El, Ellajosyula, V., Enzenhöfer, A., Ferrara, G., Filipović, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gal, T., Méndez, J. García, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Genton, E., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Gozzini, S. R., Gracia, R., Guidi, C., Guillon, B., Gutiérrez, M., Haack, C., van Haren, H., Heijboer, A., Hennig, L., Hernández-Rey, J. J., Idrissi, A., Ibnsalih, W. Idrissi, Illuminati, G., Janik, O., Joly, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Keegans, J., Kikvadze, V., Kistauri, G., Kopper, C., Kouchner, A., Kovalev, Y. Y., Krupa, L., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazar, J., Lazo, A., Stum, S. Le, Lehaut, G., Lemaître, V., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Longhitano, F., Magnani, F., Majumdar, J., Malerba, L., Mamedov, F., Manfreda, A., Manousakis, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Mastrodicasa, M., Mastroianni, S., Mauro, J., Mehta, K. C. K., Meskar, A., Miele, G., Migliozzi, P., Migneco, E., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Mori, N., Moussa, A., Mateo, I. Mozun, Muller, R., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, Oliviero, V., Orlando, A., Oukacha, E., Pacini, L., Paesani, D., González, J. Palacios, Papalashvili, G., Papini, P., Parisi, V., Parmar, A., Gomez, E. J. Pastor, Pastore, C., Păun, A. M., Păvălaş, G. E., Martínez, S. Peña, Perrin-Terrin, M., Pestel, V., Pestes, R., Petropavlova, M., Piattelli, P., Plavin, A., Poirè, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quiroz-Rangel, C. A., Randazzo, N., Ratnani, A., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Robinson, J., Romanov, A., Ros, E., Šaina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanfilippo, S., Sanguineti, M., Santonocito, D., Sapienza, P., Scaringella, M., Scarnera, M., Schnabel, J., Schumann, J., Schutte, H. M., Seneca, J., Sennan, N., Myhr, P. A. Sevle, Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Šimkovic, F., Simonelli, A., Sinopoulou, A., Spisso, B., Spurio, M., Starodubtsev, O., Stavropoulos, D., Štekl, I., Stocco, D., Taiuti, M., Takadze, G., Tayalati, Y., Thiersen, H., Thoudam, S., Melo, I. Tosta e, Trocmé, B., Tsourapis, V., Tzamariudaki, E., Ukleja, A., Vacheret, A., Valsecchi, V., Van Elewyck, V., Vannoye, G., Vannuccini, E., Vasileiadis, G., de Sola, F. Vazquez, Veutro, A., Viola, S., Vivolo, D., van Vliet, A., de Wolf, E., Lhenry-Yvon, I., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The KM3NeT observatory detected the most energetic neutrino candidate ever observed, with an energy between 72 PeV and 2.6 EeV at the 90% confidence level. The observed neutrino is likely of cosmic origin. In this article, it is investigated if the neutrino could have been produced within the Milky Way. Considering the low fluxes of the Galactic diffuse emission at these energies, the lack of a nearby potential Galactic particle accelerator in the direction of the event and the difficulty to accelerate particles to such high energies in Galactic systems, we conclude that if the event is indeed cosmic, it is most likely of extragalactic origin.

Published
2025

6. Study of tau neutrinos and non-unitary neutrino mixing with the first six detection units of KM3NeT/ORCA

Author

KM3NeT Collaboration, Aiello, S., Albert, A., Alhebsi, A. R., Alshamsi, M., Garre, S. Alves, Ambrosone, A., Ameli, F., Andre, M., Aphecetche, L., Ardid, M., Ardid, S., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardačová, Z., Baret, B., Bariego-Quintana, A., Becherini, Y., Bendahman, M., Gualandi, F. Benfenati, Benhassi, M., Bennani, M., Benoit, D. M., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bonanno, D., Bouasla, A. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Brânzaş, H., Bretaudeau, F., Breuhaus, M., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carenini, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chen, A., Cherubini, S., Chiarusi, T., Circella, M., Clark, R., Cocimano, R., Coelho, J. A. B., Coleiro, A., Condorelli, A., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Benedittis, A., De Wasseige, G., Decoene, V., Deguire, P., Del Rosso, I., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drakopoulou, E., Drouhin, D., Ducoin, J. -G., Duverne, P., Dvornický, R., Eberl, T., Eckerová, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Mentawi, S. El, Ellajosyula, V., Enzenhöfer, A., Ferrara, G., Filipović, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gagliardini, S., Gal, T., Méndez, J. García, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Genton, E., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Gozzini, S. R., Gracia, R., Guidi, C., Guillon, B., Gutiérrez, M., Haack, C., van Haren, H., Heijboer, A., Hennig, L., Hernández-Rey, J. J., Idrissi, A., Ibnsalih, W. Idrissi, Illuminati, G., Joly, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kikvadze, V., Kistauri, G., Kopper, C., Kouchner, A., Kovalev, Y. Y., Krupa, L., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazar, J., Lazo, A., Stum, S. Le, Lehaut, G., Lema^itre, V., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Longhitano, F., Magnani, F., Majumdar, J., Malerba, L., Mamedov, F., Manfreda, A., Manousakis, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Mastrodicasa, M., Mastroianni, S., Mauro, J., Mehta, K. C. K., Meskar, A., Miele, G., Migliozzi, P., Migneco, E., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Moussa, A., Mateo, I. Mozun, Muller, R., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, Oliviero, V., Orlando, A., Oukacha, E., Paesani, D., González, J. Palacios, Papalashvili, G., Parisi, V., Parmar, A., Gomez, E. J. Pastor, Pastore, C., Păun, A. M., Păvălaş, G. E., Martínez, S. Peña, Perrin-Terrin, M., Pestel, V., Pestes, R., Piattelli, P., Plavin, A., Poirè, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quiroz-Rangel, C. A., Randazzo, N., Ratnani, A., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Romanov, A., Ros, E., Šaina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanfilippo, S., Sanguineti, M., Santonocito, D., Sapienza, P., Scarnera, M., Schnabel, J., Schumann, J., Schutte, H. M., Seneca, J., Sennan, N., Sevle, P., Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Šimkovic, F., Simonelli, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Štekl, I., Taiuti, M., Takadze, G., Tayalati, Y., Thiersen, H., Thoudam, S., Melo, I. Tosta e, Trocmé, B., Tsourapis, V., Tudorache, A., Tzamariudaki, E., Ukleja, A., Vacheret, A., Valsecchi, V., Van Elewyck, V., Vannoye, G., Vasileiadis, G., de Sola, F. Vazquez, Veutro, A., Viola, S., Vivolo, D., van Vliet, A., de Wolf, E., Lhenry-Yvon, I., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Subjects
High Energy Physics - Experiment
Abstract

Oscillations of atmospheric muon and electron neutrinos produce tau neutrinos with energies in the GeV range, which can be observed by the ORCA detector of the KM3NeT neutrino telescope in the Mediterranean Sea. First measurements with ORCA6, an early subarray corresponding to about 5$\%$ of the final detector, are presented. A sample of 5828 neutrino candidates has been selected from the analysed exposure of 433 kton-years. The $\nu_\tau$ normalisation, defined as the ratio between the number of observed and expected tau neutrino events, is measured to be $S_\tau = 0.48^{+0.5}_{-0.33}$. This translates into a $\nu_\tau$ charged-current cross section measurement of $\sigma_{\tau}^{\text{meas}} = (2.5 ^{+2.6}_{-1.8}) \times 10^{-38}$ cm$^{2}$ nucleon$^{-1}$ at the median $\nu_\tau$ energy of 20.3 GeV. The result is consistent with the measurements of other experiments. In addition, the current limit on the non-unitarity parameter affecting the $\tau$-row of the neutrino mixing matrix was improved, with $\alpha_{33}>$ 0.95 at the 95$\%$ confidence level., Comment: 25 pages, 8 figures

Published
2025

7. The SPHERE infrared survey for exoplanets (SHINE). V. Complete observations, data reduction and analysis, detection performances, and final results

Author

Chomez, A., Delorme, P., Lagrange, A. -M., Gratton, R., Flasseur, O., Chauvin, G., Langlois, M., Mazoyer, J., Zurlo, A., Desidera, S., Mesa, D., Bonnefoy, M., Feldt, M., Hagelberg, J., Meyer, M., Vigan, A., Ginski, C., Kenworthy, M., Albert, D., Bergeon, S., Beuzit, J. -L., Biller, B., Bhowmik, T., Boccaletti, A., Bonavita, M., Brandner, W., Cantalloube, F., Cheetham, A., D'Orazi, V., Dominik, C., Fontanive, C., Galicher, R., Henning, Th., Janson, M., Kral, Q., Lagadec, E., Lazzoni, C., Coroller, H. Le, Ligi, R., Maire, A. -L., Marleau, G. -D., Menard, F., Messina, S., Meunier, N., Mordasini, C., Moutou, C., Müller, A., Perrot, C., Samland, M., Schmid, H. M., Schmidt, T., Squicciarini, V., Sissa, E., Turatto, M., Udry, S., Abe, L., Antichi, J., Asensio-Torres, R., Baruffolo, A., Baudoz, P., Baudrand, J., Bazzon, A., Blanchard, P., Bohn, A. J., Sevilla, S. Brown, Carbillet, M., Carle, M., Cascone, E., Charton, J., Claudi, R., Costille, A., De Caprio, V., Delboulbe, A., Dohlen, K., Engler, N., Fantinel, D., Feautrier, P., Fusco, T., Gigan, P., Girard, J. H., Giro, E., Gisler, D., Gluck, L., Gry, C., Hubin, N., Hugot, E., Jaquet, M., Kasper, M., Mignant, D. Le, Llored, M., Madec, F., Magnard, Y., Martinez, P., Maurel, D., Möller-Nilsson, O., Mouillet, D., Moulin, T., Origné, A., Pavlov, A., Perret, D., Petit, C., Pragt, J., Puget, P., Rabou, P., Ramos, J., Rickman, E. L., Rigal, F., Rochat, S., Roelfsema, R., Rousset, G., Roux, A., Salasnich, B., Sauvage, J. -F., Sevin, A., Soenke, C., Stadler, E., Suarez, M., Wahhaj, Z., Weber, L., and Wildi, F.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

During the past decade, state-of-the-art planet-finder instruments like SPHERE@VLT, coupling coronagraphic devices and extreme adaptive optics systems, unveiled, thanks to large surveys, around 20 planetary mass companions at semi-major axis greater than 10 astronomical units. Direct imaging being the only detection technique to be able to probe this outer region of planetary systems, the SPHERE infrared survey for exoplanets (SHINE) was designed and conducted from 2015 to 2021 to study the demographics of such young gas giant planets around 400 young nearby solar-type stars. In this paper, we present the observing strategy, the data quality, and the point sources analysis of the full SHINE statistical sample as well as snapSHINE. Both surveys used the SPHERE@VLT instrument with the IRDIS dual band imager in conjunction with the integral field spectrograph IFS and the angular differential imaging observing technique. All SHINE data (650 datasets), corresponding to 400 stars, including the targets of the F150 survey, are processed in a uniform manner with an advanced post-processing algorithm called PACO ASDI. An emphasis is put on the classification and identification of the most promising candidate companions. Compared to the previous early analysis SHINE F150, the use of advanced post-processing techniques significantly improved by one or 2 magnitudes (x3-x6) the contrast detection limits, which will allow us to put even tighter constraints on the radial distribution of young gas giants. This increased sensitivity directly places SHINE as the largest and deepest direct imaging survey ever conducted. We detected and classified more than 3500 physical sources. One additional substellar companion has been confirmed during the second phase of the survey (HIP 74865 B), and several new promising candidate companions are awaiting second epoch confirmations., Comment: Accepted for publication in A&A. 19 pages, 19 figures. Abstract shortened to comply with ArxiV standards. Data ingestion at the CDS is ongoing

Published
2025

8. Probing invisible neutrino decay with the first six detection units of KM3NeT/ORCA

Author

Aiello, S., Albert, A., Alhebsi, A. R., Alshamsi, M., Garre, S. Alves, Ambrosone, A., Ameli, F., Andre, M., Aphecetche, L., Ardid, M., Ardid, S., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardačová, Z., Baret, B., Bariego-Quintana, A., Becherini, Y., Bendahman, M., Gualandi, F. Benfenati, Benhassi, M., Bennani, M., Benoit, D. M., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bonanno, D., Bouasla, A. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Brânzaş, H., Bretaudeau, F., Breuhaus, M., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carenini, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chen, A., Cherubini, S., Chiarusi, T., Circella, M., Clark, R., Cocimano, R., Coelho, J. A. B., Coleiro, A., Condorelli, A., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Benedittis, A., De Wasseige, G., Decoene, V., Deguire, P., Del Rosso, I., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drakopoulou, E., Drouhin, D., Ducoin, J. -G., Duverne, P., Dvornický, R., Eberl, T., Eckerová, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Mentawi, S. El, Ellajosyula, V., Enzenhöfer, A., Ferrara, G., Filipović, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gagliardini, S., Gal, T., Méndez, J. García, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Genton, E., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Gozzini, S. R., Gracia, R., Guidi, C., Guillon, B., Gutiérrez, M., Haack, C., van Haren, H., Heijboer, A., Hennig, L., Hernández-Rey, J. J., Idrissi, A., Ibnsalih, W. Idrissi, Illuminati, G., Joly, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kikvadze, V., Kistauri, G., Kopper, C., Kouchner, A., Kovalev, Y. Y., Krupa, L., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazar, J., Lazo, A., Stum, S. Le, Lehaut, G., Lemaître, V., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Longhitano, F., Magnani, F., Majumdar, J., Malerba, L., Mamedov, F., Manfreda, A., Manousakis, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Mastrodicasa, M., Mastroianni, S., Mauro, J., Mehta, K. C. K., Meskar, A., Miele, G., Migliozzi, P., Migneco, E., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Moussa, A., Mateo, I. Mozun, Muller, R., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, Oliviero, V., Orlando, A., Oukacha, E., Paesani, D., González, J. Palacios, Papalashvili, G., Parisi, V., Parmar, A., Gomez, E. J. Pastor, Pastore, C., Păun, A. M., Păvălaş, G. E., Martínez, S. Peña, Perrin-Terrin, M., Pestel, V., Pestes, R., Piattelli, P., Plavin, A., Poiré, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quiroz-Rangel, C. A., Randazzo, N., Ratnani, A., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Romanov, A., Ros, E., Săina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanfilippo, S., Sanguineti, M., Santonocito, D., Sapienza, P., Scarnera, M., Schnabel, J., Schumann, J., Schutte, H. M., Seneca, J., Sennan, N., Sevle, P., Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Šimkovic, F., Simonelli, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Štekl, I., Taiuti, M., Takadze, G., Tayalati, Y., Thiersen, H., Thoudam, S., Melo, I. Tosta e, Trocmé, B., Tsourapis, V., Tudorache, A., Tzamariudaki, E., Ukleja, A., Vacheret, A., Valsecchi, V., Van Elewyck, V., Vannoye, G., Vasileiadis, G., de Sola, F. Vazquez, Veutro, A., Viola, S., Vivolo, D., van Vliet, A., de Wolf, E., Lhenry-Yvon, I., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Subjects
High Energy Physics - Experiment
Abstract

In the era of precision measurements of neutrino oscillation parameters, it is necessary for experiments to disentangle discrepancies that may indicate physics beyond the Standard Model in the neutrino sector. KM3NeT/ORCA is a water Cherenkov neutrino detector under construction and anchored at the bottom of the Mediterranean Sea. The detector is designed to study the oscillations of atmospheric neutrinos and determine the neutrino mass ordering. This paper focuses on the initial configuration of ORCA, referred to as ORCA6, which comprises six out of the foreseen 115 detection units of photosensors. A high-purity neutrino sample was extracted during 2020 and 2021, corresponding to an exposure of 433 kton-years. This sample is analysed following a binned log-likelihood approach to search for invisible neutrino decay, in a three-flavour neutrino oscillation scenario, where the third neutrino mass state $\nu_3$ decays into an invisible state, e.g. a sterile neutrino. The resulting best fit of the invisible neutrino decay parameter is $\alpha_3 = 0.92^{+1.08}_{-0.57}\times 10^{-4}~\mathrm{eV^2}$, corresponding to a scenario with $\theta_{23}$ in the second octant and normal neutrino mass ordering. The results are consistent with the Standard Model, within a $2.1\,\sigma$ interval., Comment: 20 pages, 8 figures

Published
2025

9. Periodic Gamma-ray Modulation of the blazar PG 1553+113 Confirmed by Fermi-LAT and Multi-wavelength Observations

Author

Abdollahi, S., Baldini, L., Barbiellini, G., Bellazzini, R., Berenji, B., Bissaldi, E., Blandford, R. D., Bonino, R., Bruel, P., Buson, S., Cameron, R. A., Caraveo, P. A., Casaburo, F., Cavazzuti, E., Cheung, C. C., Chiaro, G., Ciprini, S., Cozzolongo, G., Orestano, P. Cristarella, Cutini, S., D'Ammando, F., Di Lalla, N., Dirirsa, F., Di Venere, L., Domínguez, A., Fegan, S. J., Ferrara, E. C., Fiori, A., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Garrappa, S., Gasparrini, D., Germani, S., Giglietto, N., Giordano, F., Giroletti, M., Green, D., Grenier, I. A., Guiriec, S., Hays, E., Horan, D., Kuss, M., Larsson, S., Laurenti, M., Li, J., Liodakis, I., Longo, F., Loparco, F., Lott, B., Lovellette, M. N., Lubrano, P., Maldera, S., Malyshev, D., Manfreda, A., Marcotulli, L., Martí-Devesa, G., Mazziotta, M. N., Mereu, I., Michelson, P. F., Mitthumsiri, W., Mizuno, T., Monzani, M. E., Morselli, A., Moskalenko, I. V., Negro, M., Omodei, N., Orienti, M., Orlando, E., Ormes, J. F., Paneque, D., Perri, M., Persic, M., Pesce-Rollins, M., Porter, T. A., Principe, G., Rainò, S., Rando, R., Rani, B., Razzano, M., Reimer, A., Reimer, O., Parkinson, P. M. Saz, Scotton, L., Serini, D., Sesana, A., Sgrò, C., Siskind, E. J., Spandre, G., Spinelli, P., Suson, D. J., Tajima, H., Takahashi, M. N., Tak, D., Thayer, J. B., Thompson, D. J., Torres, D. F., Valverde, J., Verrecchia, F., and Zaharijas, G.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

A 2.1-year periodic oscillation of the gamma-ray flux from the blazar PG 1553+113 has previously been tentatively identified in almost 7 year of data from the Fermi Large Area Telescope. After 15 years of Fermi sky-survey observations, doubling the total time range, we report >7 cycle gamma-ray modulation with an estimated significance of 4 sigma against stochastic red noise. Independent determinations of oscillation period and phase in the earlier and the new data are in close agreement (chance probability <0.01). Pulse timing over the full light curve is also consistent with a coherent periodicity. Multiwavelength new data from Swift X-Ray Telescope, Burst Alert Telescope, and UVOT, and from KAIT, Catalina Sky Survey, All-Sky Automated Survey for Supernovae, and Owens Valley Radio Observatory ground-based observatories as well as archival Rossi X-Ray Timing Explorer satellite-All Sky Monitor data, published optical data of Tuorla, and optical historical Harvard plates data are included in our work. Optical and radio light curves show clear correlations with the gamma-ray modulation, possibly with a nonconstant time lag for the radio flux. We interpret the gamma-ray periodicity as possibly arising from a pulsational accretion flow in a sub-parsec binary supermassive black hole system of elevated mass ratio, with orbital modulation of the supplied material and energy in the jet. Other astrophysical scenarios introduced include instabilities, disk and jet precession, rotation or nutation, and perturbations by massive stars or intermediate-mass black holes in polar orbit., Comment: 23 pages, 14 figures, 20 plots, 1 table, accepted and published by The Astrophysical Journal. Article produced by the Fermi Large Area Telescope (LAT) Collaboration

Published
2025
Full Text
View/download PDF

10. Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost.

Author

Zhang, Bo, Fong, Youyi, Dang, Lauren, Fintzi, Jonathan, Chen, Shiyu, Wang, Jing, Rouphael, Nadine, Branche, Angela, Diemert, David, Falsey, Ann, Graciaa, Daniel, Baden, Lindsey, Frey, Sharon, Whitaker, Jennifer, Little, Susan, Kamidani, Satoshi, Walter, Emmanuel, Novak, Richard, Rupp, Richard, Jackson, Lisa, Yu, Chenchen, Magaret, Craig, Molitor, Cindy, Borate, Bhavesh, Busch, Sydney, Benkeser, David, Netzl, Antonia, Smith, Derek, Babu, Tara, Kottkamp, Angelica, Luetkemeyer, Anne, Immergluck, Lilly, Presti, Rachel, Bäcker, Martín, Winokur, Patricia, Mahgoub, Siham, Goepfert, Paul, Fusco, Dahlene, Atmar, Robert, Posavad, Christine, Mu, Jinjian, Makowski, Mat, Makhene, Mamodikoe, Nayak, Seema, Roberts, Paul, Gilbert, Peter, and Follmann, Dean

Subjects
Humans, Antibodies, Neutralizing, COVID-19, COVID-19 Vaccines, SARS-CoV-2, Antibodies, Viral, Immunization, Secondary, Female, Male, Adult, Middle Aged, Spike Glycoprotein, Coronavirus, mRNA Vaccines
Abstract

Neutralizing antibody titer has been a surrogate endpoint for guiding COVID-19 vaccine approval and use, although the pandemics evolution and the introduction of variant-adapted vaccine boosters raise questions as to this surrogates contemporary performance. For 985 recipients of an mRNA second bivalent or monovalent booster containing various Spike inserts [Prototype (Ancestral), Beta, Delta, and/or Omicron BA.1 or BA.4/5] in the COVAIL trial (NCT05289037), titers against 5 strains were assessed as correlates of risk of symptomatic COVID-19 (COVID-19) and as correlates of relative (Pfizer-BioNTech Omicron vs. Prototype) booster protection against COVID-19 over 6 months of follow-up during the BA.2-BA.5 Omicron-dominant period. Consistently across the Moderna and Pfizer-BioNTech vaccine platforms and across all variant Spike inserts assessed, both peak and exposure-proximal (predicted-at-exposure) titers correlated with lower Omicron COVID-19 risk in individuals previously infected with SARS-CoV-2, albeit significantly less so in naïve individuals [e.g., exposure-proximal hazard ratio per 10-fold increase in BA.1 titer 0.74 (95% CI 0.59, 0.94) for naïve vs. 0.41 (95% CI 0.23, 0.64) for non-naïve; interaction p = 0.013]. Neutralizing antibody titer was a strong inverse correlate of Omicron COVID-19 in non-naïve individuals and a weaker correlate in naïve individuals, posing questions about how prior infection alters the neutralization correlate.

Published
2025

11. Observation of a spectral hardening in cosmic ray boron spectrum with the DAMPE space mission

Author

DAMPE Collaboration, Alemanno, F., Altomare, C., An, Q., Azzarello, P., Barbato, F. C. T., Bernardini, P., Bi, X. J., Boutin, H., Cagnoli, I., Cai, M. S., Casilli, E., Catanzani, E., Chang, J., Chen, D. Y., Chen, J. L., Chen, Z. F., Chen, Z. X., Coppin, P., Cui, M. Y., Cui, T. S., Cui, Y. X., De Mitri, I., de Palma, F., Di Giovanni, A., Dong, T. K., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., Fan, R. R., Fan, Y. Z., Fang, F., Fang, K., Feng, C. Q., Feng, L., Frieden, J. M., Fusco, P., Gao, M., Gargano, F., Ghose, E., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, L. Y., Jiang, Y. Z., Jiang, W., Kong, J., Kotenko, A., Kyratzis, D., Lei, S. J., Li, W. H., Li, W. L., Li, X., Li, X. Q., Liang, Y. M., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, Y., Loparco, F., Ma, M., Ma, P. X., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Parenti, A., Peng, W. X., Peng, X. Y., Perrina, C., Putti-Garcia, E., Qiao, R., Rao, J. N., Sarkar, R., Savina, P., Serpolla, A., Shangguan, Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Silveri, L., Song, J. X., Stolpovskiy, M., Su, H., Su, M., Sun, H. R., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Wang, J. Z., Wang, L. G., Wang, S., Wang, X. L., Wang, Y. F., Wang, Y., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, S. S., Wu, X., Xia, Z. Q., Xu, E. H., Xu, H. T., Xu, J., Xu, Z. H., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yao, H. J., Yu, Y. H., Yuan, Q., Yue, C., Zang, J. J., Zhang, S. X., Zhang, W. Z., Zhang, Yan, Zhang, Yi, Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, C., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., and Zhu, Y.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

Secondary cosmic ray fluxes are important probes of the propagation and interaction of high-energy particles in the Galaxy. Recent measurements of primary and secondary cosmic ray nuclei have revealed unexpected spectral features that demand a deeper understanding. In this work we report the direct measurement of the cosmic ray boron spectrum from 10 GeV/n to 8 TeV/n with eight years of data collected by the Dark Matter Particle Explorer (DAMPE) mission. The measured spectrum shows an evident hardening at $182\pm24$ GeV/n with a spectral power index of $\gamma_1 = 3.02 \pm 0.01$ before the break and an index change of $\Delta \gamma = 0.31 \pm 0.05$ after the break. A simple power law model is disfavored at a confidence level of 8$\sigma$. Compared with the hardenings measured in the DAMPE proton and helium spectra, the secondary boron spectrum hardens roughly twice as much as these primaries, which is consistent with a propagation related mechanism to interpret the spectral hardenings of cosmic rays observed at hundreds of GeV/n., Comment: 10 pages, 10 figures, submitted to PRL

Published
2024

12. The Cost of Consistency: Submodular Maximization with Constant Recourse

Author

Dütting, Paul, Fusco, Federico, Lattanzi, Silvio, Norouzi-Fard, Ashkan, Svensson, Ola, and Zadimoghaddam, Morteza

Subjects
Computer Science - Data Structures and Algorithms, Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

In this work, we study online submodular maximization, and how the requirement of maintaining a stable solution impacts the approximation. In particular, we seek bounds on the best-possible approximation ratio that is attainable when the algorithm is allowed to make at most a constant number of updates per step. We show a tight information-theoretic bound of $\tfrac{2}{3}$ for general monotone submodular functions, and an improved (also tight) bound of $\tfrac{3}{4}$ for coverage functions. Since both these bounds are attained by non poly-time algorithms, we also give a poly-time randomized algorithm that achieves a $0.51$-approximation. Combined with an information-theoretic hardness of $\tfrac{1}{2}$ for deterministic algorithms from prior work, our work thus shows a separation between deterministic and randomized algorithms, both information theoretically and for poly-time algorithms.

Published
2024

13. Object Agnostic 3D Lifting in Space and Time

Author

Fusco, Christopher, Ch'ng, Shin-Fang, Dabhi, Mosam, and Lucey, Simon

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence
Abstract

We present a spatio-temporal perspective on category-agnostic 3D lifting of 2D keypoints over a temporal sequence. Our approach differs from existing state-of-the-art methods that are either: (i) object-agnostic, but can only operate on individual frames, or (ii) can model space-time dependencies, but are only designed to work with a single object category. Our approach is grounded in two core principles. First, general information about similar objects can be leveraged to achieve better performance when there is little object-specific training data. Second, a temporally-proximate context window is advantageous for achieving consistency throughout a sequence. These two principles allow us to outperform current state-of-the-art methods on per-frame and per-sequence metrics for a variety of animal categories. Lastly, we release a new synthetic dataset containing 3D skeletons and motion sequences for a variety of animal categories., Comment: 3DV 2025

Published
2024

14. Search for non-standard neutrino interactions with the first six detection units of KM3NeT/ORCA

Author

Aiello, S., Albert, A., Alhebsi, A. R., Alshamsi, M., Garre, S. Alves, Ambrosone, A., Ameli, F., Andre, M., Aphecetche, L., Ardid, M., Ardid, S., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardačová, Z., Baret, B., Bariego-Quintana, A., Becherini, Y., Bendahman, M., Benfenati, F., Benhassi, M., Bennani, M., Benoit, D. M., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bonanno, D., Bouasla, A. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Brânzăş, H., Bretaudeau, F., Breuhaus, M., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carenini, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chen, A., Cherubini, S., Chiarusi, T., Circella, M., Clark, R., Cocimano, R., Coelho, J. A. B., Coleiro, A., Condorelli, A., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Benedittis, A., De Martino, B., De Wasseige, G., Decoene, V., Del Rosso, I., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drakopoulou, E., Drouhin, D., Ducoin, J. -G., Dvornický, R., Eberl, T., Eckerová, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Ellajosyula, V., Enzenhöfer, A., Ferrara, G., Filipović, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gagliardini, S., Gal, T., Méndez, J. García, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Genton, E., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Gozzini, S. R., Gracia, R., Guidi, C., Guillon, B., Gutiérrez, M., Haack, C., van Haren, H., Heijboer, A., Hennig, L., Hernández-Rey, J. J., Ibnsalih, W. Idrissi, Illuminati, G., Joly, D., de Jong, M., de Jong, P., Jung, B. J., Kistauri, G., Kopper, C., Kouchner, A., Kovalev, Y. Y., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazar, J., Lazo, A., Stum, S. Le, Lehaut, G., Lemaître, V., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Longhitano, F., Magnani, F., Majumdar, J., Malerba, L., Mamedov, F., Manfreda, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Mastrodicasa, M., Mastroianni, S., Mauro, J., Miele, G., Migliozzi, P., Migneco, E., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Moussa, A., Mateo, I. Mozun, Muller, R., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, Oliviero, V., Orlando, A., Oukacha, E., Paesani, D., González, J. Palacios, Papalashvili, G., Parisi, V., Gómez, E. J. Pastor, Pastore, C., Păun, A. M., Păvălaş, G. E., Martínez, S. Peña, Perrin-Terrin, M., Pestel, V., Pestes, R., Piattelli, P., Plavin, A., Poiré, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quiroz-Rangel, C. A., Randazzo, N., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Romanov, A., Ros, E., Šaina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanfilippo, S., Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schumann, J., Schutte, H. M., Seneca, J., Sennan, N., Sevle, P., Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Šimkovic, F., Simonelli, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Štekl, I., Taiuti, M., Takadze, G., Tayalati, Y., Thiersen, H., Thoudam, S., Melo, I. Tosta e, Trocmé, B., Tsourapis, V., Tudorache, A., Tzamariudaki, E., Ukleja, A., Vacheret, A., Valsecchi, V., Van Elewyck, V., Vannoye, G., Vasileiadis, G., de Sola, F. Vazquez, Veutro, A., Viola, S., Vivolo, D., van Vliet, A., de Wolf, E., Lhenry-Yvon, I., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Subjects
High Energy Physics - Experiment
Abstract

KM3NeT/ORCA is an underwater neutrino telescope under construction in the Mediterranean Sea. Its primary scientific goal is to measure the atmospheric neutrino oscillation parameters and to determine the neutrino mass ordering. ORCA can constrain the oscillation parameters $\Delta m^{2}_{31}$ and $\theta_{23}$ by reconstructing the arrival direction and energy of multi-GeV neutrinos crossing the Earth. Searches for deviations from the Standard Model of particle physics in the forward scattering of neutrinos inside Earth matter, produced by Non-Standard Interactions, can be conducted by investigating distortions of the standard oscillation pattern of neutrinos of all flavours. This work reports on the results of the search for non-standard neutrino interactions using the first six detection units of ORCA and 433 kton-years of exposure. No significant deviation from standard interactions was found in a sample of 5828 events reconstructed in the 1 GeV$-$1 TeV energy range. The flavour structure of the non-standard coupling was constrained at 90\% confidence level to be $|\varepsilon_{\mu\tau} | \leq 5.4 \times 10^{-3}$, $|\varepsilon_{e\tau} | \leq 7.4 \times 10^{-2}$, $|\varepsilon_{e\mu} | \leq 5.6 \times 10^{-2}$ and $-0.015 \leq \varepsilon_{\tau\tau} - \varepsilon_{\mu\mu} \leq 0.017$. The results are comparable to the current most stringent limits placed on the parameters by other experiments.

Published
2024

15. Harnessing LLMs for Educational Content-Driven Italian Crossword Generation

Author

Zeinalipour, Kamyar, Fusco, Achille, Zanollo, Asya, Maggini, Marco, and Gori, Marco

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence
Abstract

In this work, we unveil a novel tool for generating Italian crossword puzzles from text, utilizing advanced language models such as GPT-4o, Mistral-7B-Instruct-v0.3, and Llama3-8b-Instruct. Crafted specifically for educational applications, this cutting-edge generator makes use of the comprehensive Italian-Clue-Instruct dataset, which comprises over 30,000 entries including diverse text, solutions, and types of clues. This carefully assembled dataset is designed to facilitate the creation of contextually relevant clues in various styles associated with specific texts and keywords. The study delves into four distinctive styles of crossword clues: those without format constraints, those formed as definite determiner phrases, copular sentences, and bare noun phrases. Each style introduces unique linguistic structures to diversify clue presentation. Given the lack of sophisticated educational tools tailored to the Italian language, this project seeks to enhance learning experiences and cognitive development through an engaging, interactive platform. By meshing state-of-the-art AI with contemporary educational strategies, our tool can dynamically generate crossword puzzles from Italian educational materials, thereby providing an enjoyable and interactive learning environment. This technological advancement not only redefines educational paradigms but also sets a new benchmark for interactive and cognitive language learning solutions., Comment: This paper has been accepted for presentation at CLiC.it 2024

Published
2024

16. First Searches for Dark Matter with the KM3NeT Neutrino Telescopes

Author

KM3NeT Collaboration, Aiello, S., Albert, A., Alhebsi, A. R., Alshamsi, M., Garre, S. Alves, Ambrosone, A., Ameli, F., Andre, M., Aphecetche, L., Ardid, M., Ardid, S., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardačová, Z., Baret, B., Bariego-Quintana, A., Becherini, Y., Bendahman, M., Benfenati, F., Benhassi, M., Bennani, M., Benoit, D. M., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bonanno, D., Bouasla, A. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Brânzăş, H., Bretaudeau, F., Breuhaus, M., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carenini, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chen, A., Cherubini, S., Chiarusi, T., Circella, M., Clark, R., Cocimano, R., Coelho, J. A. B., Coleiro, A., Condorelli, A., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Benedittis, A., De Martino, B., De Wasseige, G., Decoene, V., Del Rosso, I., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drakopoulou, E., Drouhin, D., Ducoin, J. -G., Dvornický, R., Eberl, T., Eckerová, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Ellajosyula, V., Enzenhöfer, A., Ferrara, G., Filipović, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gagliardini, S., Gal, T., Méndez, J. García, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Genton, E., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Gozzini, S. R., Gracia, R., Guidi, C., Guillon, B., Gutiérrez, M., Haack, C., van Haren, H., Heijboer, A., Hennig, L., Hernández-Rey, J. J., Ibnsalih, W. Idrissi, Illuminati, G., Joly, D., de Jong, M., de Jong, P., Jung, B. J., Kistauri, G., Kopper, C., Kouchner, A., Kovalev, Y. Y., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazar, J., Lazo, A., Stum, S. Le, Lehaut, G., Lemaître, V., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Longhitano, F., Magnani, F., Majumdar, J., Malerba, L., Mamedov, F., Manfreda, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Mastrodicasa, M., Mastroianni, S., Mauro, J., Miele, G., Migliozzi, P., Migneco, E., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Moussa, A., Mateo, I. Mozun, Muller, R., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, Oliviero, V., Orlando, A., Oukacha, E., Paesani, D., González, J. Palacios, Papalashvili, G., Parisi, V., Gómez, E. J. Pastor, Pastore, C., Păun, A. M., Păvălaş, G. E., Martínez, S. Peña, Perrin-Terrin, M., Pestel, V., Pestes, R., Piattelli, P., Plavin, A., Poiré, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quiroz-Rangel, C. A., Randazzo, N., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Romanov, A., Ros, E., Šaina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanfilippo, S., Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schumann, J., Schutte, H. M., Seneca, J., Sennan, N., Sevle, P., Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Šimkovic, F., Simonelli, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Štekl, I., Taiuti, M., Takadze, G., Tayalati, Y., Thiersen, H., Thoudam, S., Melo, I. Tosta e, Trocmé, B., Tsourapis, V., Tudorache, A., Tzamariudaki, E., Ukleja, A., Vacheret, A., Valsecchi, V., Van Elewyck, V., Vannoye, G., Vasileiadis, G., de Sola, F. Vazquez, Veutro, A., Viola, S., Vivolo, D., van Vliet, A., de Wolf, E., Lhenry-Yvon, I., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Indirect dark matter detection methods are used to observe the products of dark matter annihilations or decays originating from astrophysical objects where large amounts of dark matter are thought to accumulate. With neutrino telescopes, an excess of neutrinos is searched for in nearby dark matter reservoirs, such as the Sun and the Galactic Centre, which could potentially produce a sizeable flux of Standard Model particles. The KM3NeT infrastructure, currently under construction, comprises the ARCA and ORCA undersea \v{C}erenkov neutrino detectors located at two different sites in the Mediterranean Sea, offshore of Italy and France, respectively. The two detector configurations are optimised for the detection of neutrinos of different energies, enabling the search for dark matter particles with masses ranging from a few GeV/c$^2$ to hundreds of TeV/c$^2$. In this work, searches for dark matter annihilations in the Galactic Centre and the Sun with data samples taken with the first configurations of both detectors are presented. No significant excess over the expected background was found in either of the two analyses. Limits on the velocity-averaged self-annihilation cross section of dark matter particles are computed for five different primary annihilation channels in the Galactic Centre. For the Sun, limits on the spin-dependent and spin-independent scattering cross sections of dark matter with nucleons are given for three annihilation channels.

Published
2024

17. Search for Extended GeV Sources in the Inner Galactic Plane

Author

Abdollahi, S., Acero, F., Acharyya, A., Adelfio, A., Ajello, M., Baldini, L., Ballet, J., Bartolini, C., Gonzalez, J. Becerra, Bellazzini, R., Bissaldi, E., Bonino, R., Bruel, P., Cameron, R. A., Caraveo, P. A., Castro, D., Cavazzuti, E., Cheung, C. C., Cibrario, N., Ciprini, S., Cozzolongo, G., Orestano, P. Cristarella, Cuoco, A., Cutini, S., D'Ammando, F., Di Lalla, N., Dinesh, A., Di Venere, L., Domínguez, A., Fiori, A., Funk, S., Fusco, P., Gargano, F., Gasbarra, C., Gasparrini, D., Germani, S., Giacchino, F., Giglietto, N., Giliberti, M., Giordano, F., Giroletti, M., Green, D., Grenier, I. A., Guillemot, L., Guiriec, S., Gupta, R., Hashizume, M., Hays, E., Hewitt, J. W., Horan, D., Hou, X., Kayanoki, T., Kuss, M., Laviron, A., Lemoine-Goumard, M., Liguori, A., Li, J., Liodakis, I., Loizzo, P., Longo, F., Loparco, F., Lorusso, L., Lovellette, M. N., Lubrano, P., Maldera, S., Malyshev, D., Martí-Devesa, G., Martin, P., Mazziotta, M. N., Mereu, I., Michelson, P. F., Mirabal, N., Mitthumsiri, W., Mizuno, T., Monti-Guarnieri, P., Monzani, M. E., Morselli, A., Moskalenko, I. V., Negro, M., Omodei, N., Orienti, M., Orlando, E., Paneque, D., Panzarini, G., Persic, M., Pesce-Rollins, M., Pillera, R., Porter, T. A., Rainò, S., Rando, R., Razzano, M., Reimer, A., Reimer, O., Bernal, M. Rocamora, Sánchez-Conde, M., Parkinson, P. M. Saz, Serini, D., Sgrò, C., Siskind, E. J., Smith, D. A., Spandre, G., Spinelli, P., Strong, A. W., Suson, D. J., Tajima, H., Thayer, J. B., Torres, D. F., Valverde, J., Wadiasingh, Z., Wood, K., and Zaharijas, G.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The recent detection of extended $\gamma$-ray emission around middle-aged pulsars is interpreted as inverse-Compton scattering of ambient photons by electron-positron pairs escaping the pulsar wind nebula, which are confined near the system by unclear mechanisms. This emerging population of $\gamma$-ray sources was first discovered at TeV energies and remains underexplored in the GeV range. To address this, we conducted a systematic search for extended sources along the Galactic plane using 14 years of Fermi-LAT data above 10 GeV, aiming to identify a number of pulsar halo candidates and extend our view to lower energies. The search covered the inner Galactic plane ($\lvert l\rvert\leq$ 100$^{\circ}$, $\lvert b\rvert\leq$ 1$^{\circ}$) and the positions of known TeV sources and bright pulsars, yielding broader astrophysical interest. We found 40 such sources, forming the Second Fermi Galactic Extended Sources Catalog (2FGES), most with 68% containment radii smaller than 1.0$^{\circ}$ and relatively hard spectra with photon indices below 2.5. We assessed detection robustness using field-specific alternative interstellar emission models and by inspecting significance maps. Noting 13 sources previously known as extended in the 4FGL-DR3 catalog and five dubious sources from complex regions, we report 22 newly detected extended sources above 10 GeV. Of these, 13 coincide with H.E.S.S., HAWC, or LHAASO sources; six coincide with bright pulsars (including four also coincident with TeV sources); six are associated with 4FGL point sources only; and one has no association in the scanned catalogs. Notably, six to eight sources may be related to pulsars as classical pulsar wind nebulae or pulsar halos., Comment: 43 pages, 17 figures, 11 tables

Published
2024

18. gSeaGen code by KM3NeT: an efficient tool to propagate muons simulated with CORSIKA

Author

Aiello, S., Albert, A., Alhebsi, A. R., Alshamsi, M., Garre, S. Alves, Ambrosone, A., Ameli, F., Andre, M., Aphecetche, L., Ardid, M., Ardid, S., Atmani, H., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardačová, Z., Baret, B., Bariego-Quintana, A., Becherini, Y., Bendahman, M., Benfenati, F., Benhassi, M., Bennani, M., Benoit, D. M., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bonanno, D., Bouasla, A. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Brânzaş, H., Bretaudeau, F., Breuhaus, M., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carenini, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chen, A., Cherubini, S., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Condorelli, A., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Benedittis, A., De Martino, B., De Wasseige, G., Decoene, V., Del Rosso, I., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drakopoulou, E., Drouhin, D., Ducoin, J. -G., Dvornický, R., Eberl, T., Eckerová, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Ellajosyula, V., Enzenhöfer, A., Ferrara, G., Filipović, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gagliardini, S., Gal, T., Méndez, J. García, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Genton, E., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Gozzini, S. R., Gracia, R., Guidi, C., Guillon, B., Gutiérrez, M., Haack, C., van Haren, H., Heijboer, A., Hennig, L., Hernández-Rey, J. J., Ibnsalih, W. Idrissi, Illuminati, G., Joly, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kistauri, G., Kopper, C., Kouchner, A., Kovalev, Y. Y., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Stum, S. Le, Lehaut, G., Lemaître, V., Leonora, E., Lessing, N., Clark, M. Lindsey, Longhitano, F., Magnani, F., Majumdar, J., Malerba, L., Mamedov, F., Mańczak, J., Manfreda, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Mastrodicasa, M., Mastroianni, S., Mauro, J., Miele, G., Migliozzi, P., Migneco, E., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Moussa, A., Mateo, I. Mozun, Muller, R., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, Oliviero, V., Orlando, A., Oukacha, E., Paesani, D., González, J. Palacios, Papalashvili, G., Parisi, V., Gomez, E. J. Pastor, Pastore, C., Păun, A. M., Păvălaş, G. E., Martínez, S. Peña, Perrin-Terrin, M., Pestel, V., Pestes, R., Piattelli, P., Plavin, A., Poirè, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quiroz-Rangel, C. A., Randazzo, N., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Robinson, J., Romanov, A., Ros, E., Šaina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanfilippo, S., Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Šimkovic, F., Simonelli, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Štekl, I., Stellacci, S. M., Taiuti, M., Tayalati, Y., Thiersen, H., Thoudam, S., Melo, I. Tosta e, Trocmé, B., Tsourapis, V., Tudorache, A., Tzamariudaki, E., Ukleja, A., Vacheret, A., Valsecchi, V., Van Elewyck, V., Vannoye, G., Vasileiadis, G., de Sola, F. Vazquez, Veutro, A., Viola, S., Vivolo, D., van Vliet, A., de Wolf, E., Lhenry-Yvon, I., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Subjects
High Energy Physics - Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Computational Physics
Abstract

The KM3NeT Collaboration has tackled a common challenge faced by the astroparticle physics community, namely adapting the experiment-specific simulation software to work with the CORSIKA air shower simulation output. The proposed solution is an extension of the open-source code gSeaGen, allowing for the transport of muons generated by CORSIKA to a detector of any size at an arbitrary depth. The gSeaGen code was not only extended in terms of functionalities but also underwent a thorough redesign of the muon propagation routine, resulting in a more accurate and efficient simulation. This paper presents the capabilities of the new gSeaGen code as well as prospects for further developments., Comment: 27 pages, 13 figures, submitted to Computer Physics Communications

Published
2024

19. On Spatio-Temporal Stochastic Frontier Models

Author

Fusco, Elisa, Arbia, Giuseppe, Vidoli, Francesco, and Nardelli, Vincenzo

Subjects
Statistics - Methodology, Economics - Econometrics, Statistics - Applications, 91B72, 62P20
Abstract

In the literature on stochastic frontier models until the early 2000s, the joint consideration of spatial and temporal dimensions was often inadequately addressed, if not completely neglected. However, from an evolutionary economics perspective, the production process of the decision-making units constantly changes over both dimensions: it is not stable over time due to managerial enhancements and/or internal or external shocks, and is influenced by the nearest territorial neighbours. This paper proposes an extension of the Fusco and Vidoli [2013] SEM-like approach, which globally accounts for spatial and temporal effects in the term of inefficiency. In particular, coherently with the stochastic panel frontier literature, two different versions of the model are proposed: the time-invariant and the time-varying spatial stochastic frontier models. In order to evaluate the inferential properties of the proposed estimators, we first run Monte Carlo experiments and we then present the results of an application to a set of commonly referenced data, demonstrating robustness and stability of estimates across all scenarios., Comment: 14 pages, 3 figures, 5 tables, presented at the SEA2024: XVIII World Conference of Spatial Econometrics Association (A tribute to Jean Paelinck). Spatial Econometrics: Past and future 50 years, 24-25 June 2024, Groningen, the Netherlands

Published
2024

20. Performance comparison of the Shack-Hartmann and pyramid wavefront sensors with a laser guide star for 40 m telescopes

Author

Oyarzun, Francisco, Heritier, Cedric-Taissir, Chambouleyron, Vincent, Fusco, Thierry, Rouquette, Paul, and Neichel, Benoit

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Context. The new giant segmented mirror telescopes will use laser guide stars (LGS) for their adaptive optics (AO) systems. Two options to use as wavefront sensors (WFS) are the Shack-Hartmann wavefront sensor (SHWFS) and the pyramid wavefront sensor (PWFS). Aims. In this paper, we compare the noise performance of the PWFS and the SHWFS. We aim to find which of the two WFS is the best to use in a single or tomographic configuration. Methods. To compute the noise performance we extended a noise model developed for the PWFS to be used with the SHWFS. To do this, we expressed the centroiding algorithm of the SHWFS as a matrix-vector multiplication, which allowed us to use the statistics of noise to compute its propagation through the AO loop. We validated the noise model with end-to-end simulations for telescopes of 8 and 16 m in diameter. Results. For an AO system with only one WFS, we found that, given the same number of subapertures, the PWFS outperforms the SHWFS. For a 40 m telescope, the limiting magnitude of the PWFS is around 1 magnitude higher than the SHWFS. When using multiple WFS and a Generalized least squares estimator to combine the signal, our model predicts that in a tomographic system, the SHWFS performs better than the PWFS having a limiting magnitude 0.3 magnitudes higher. If using sub-electron RON detectors for the PWFS, then the performances are almost identical between the two WFSs Conclusions. We conclude that when using a single WFS with LGS, the PWFS is a better alternative than the SH. However, for a tomographic system, either would have almost the same performance.

Published
2024

21. Search for quantum decoherence in neutrino oscillations with six detection units of KM3NeT/ORCA

Author

Aiello, S., Albert, A., Alhebsi, A. R., Alshamsi, M., Garre, S. Alves, Ambrosone, A., Ameli, F., Andre, M., Aphecetche, L., Ardid, M., Ardid, S., Atmani, H., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardacova, Z., Baret, B., Bariego-Quintana, A., Becherini, Y., Bendahman, M., Benfenati, F., Benhassi, M., Bennani, M., Benoit, D. M., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bonanno, D., Bouasla, A. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Branzas, H., Bretaudeau, F., Breuhaus, M., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carenini, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chen, A., Cherubini, S., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Condorelli, A., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Benedittis, A., De Martino, B., De Wasseige, G., Decoene, V., Del Rosso, I., Di Mauro, L. S., Di Palma, I., Diaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drakopoulou, E., Drouhin, D., Ducoin, J. -G., Dvornicky, R., Eberl, T., Eckerova, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Ellajosyula, V., Enzenhoefer, A., Ferrara, G., Filipovic, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gagliardini, S., Gal, T., Mendez, J. Garcia, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Genton, E., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Gozzini, S. R., Gracia, R., Guidi, C., Guillon, B., Gutierrez, M., Haack, C., van Haren, H., Heijboer, A., Hennig, L., Hernandez-Rey, J. J., Ibnsalih, W. Idrissi, Illuminati, G., Joly, D., de Jong, M., de Jong, P., Jung, B. J., Kistauri, G., Kopper, C., Kouchner, A., Kovalev, Y. Y., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Stum, S. Le, Lehaut, G., Lemaitre, V., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Longhitano, F., Magnani, F., Majumdar, J., Malerba, L., Mamedov, F., Manczak, J., Manfreda, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Mastrodicasa, M., Mastroianni, S., Mauro, J., Miele, G., Migliozzi, P., Migneco, E., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Moussa, A., Mateo, I. Mozun, Muller, R., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. O., Oliviero, V., Orlando, A., Oukacha, E., Gonzalez, D. Paesaniy J. Palacios, Papalashvili, G., Parisi, V., Gomez, E. J. Pastor, Pastore, C., Paun, A. M., Pavala, G. E., Martinez, S. Pena, Perrin-Terrin, M., Pestel, V., Pestes, R., Piattelli, P., Plavin, A., Poire, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quiroz-Rangel, C. A., Randazzo, N., Razzaque, S., Rea, I. C., Real, D., Robinson, G. Riccobene. J., Romanov, A., Ros, E., Saina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sanchez, Sanfilippo, S., Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Simkovic, F., Simonelli, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Stekl, I., Stellacci, S. M., Taiuti, M., Tayalati, Y., Thiersen, H., Thoudam, S., Tosta, I., Melo, e, Trocme, B., Tsourapis, V., Tudorache, A., Tzamariudaki, E., Ukleja, A., Vacheret, A., Valsecchi, V., Van Elewyck, V., Vannoye, G., Vasileiadis, G., de Sola, F. Vazquez, Veutro, A., Viola, S., Vivolo, D., van Vliet, A., de Wolf, E., Lhenry-Yvon, I., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., and Zywucka, N.

Subjects
High Energy Physics - Experiment
Abstract

Neutrinos described as an open quantum system may interact with the environment which introduces stochastic perturbations to their quantum phase. This mechanism leads to a loss of coherence along the propagation of the neutrino $-$ a phenomenon commonly referred to as decoherence $-$ and ultimately, to a modification of the oscillation probabilities. Fluctuations in space-time, as envisaged by various theories of quantum gravity, are a potential candidate for a decoherence-inducing environment. Consequently, the search for decoherence provides a rare opportunity to investigate quantum gravitational effects which are usually beyond the reach of current experiments. In this work, quantum decoherence effects are searched for in neutrino data collected by the KM3NeT/ORCA detector from January 2020 to November 2021. The analysis focuses on atmospheric neutrinos within the energy range of a few GeV to $100\,\mathrm{GeV}$. Adopting the open quantum system framework, decoherence is described in a phenomenological manner with the strength of the effect given by the parameters $\Gamma_{21}$ and $\Gamma_{31}$. Following previous studies, a dependence of the type $\Gamma_{ij} \propto (E/E_0)^n$ on the neutrino energy is assumed and the cases $n = -2,-1$ are explored. No significant deviation with respect to the standard oscillation hypothesis is observed. Therefore, $90\,\%$ CL upper limits are estimated as $\Gamma_{21} < 4.6\cdot 10^{-21}\,$GeV and $\Gamma_{31} < 8.4\cdot 10^{-21}\,$GeV for $n = -2$, and $\Gamma_{21} < 1.9\cdot 10^{-22}\,$GeV and $\Gamma_{31} < 2.7\cdot 10^{-22}\,$GeV for $n = -1$, respectively., Comment: 17 pages, 5 figures

Published
2024

30. Efficacy and Safety of Remdesivir in People With Impaired Kidney Function Hospitalized for COVID-19 Pneumonia: A Randomized Clinical Trial.

Author

Sise, Meghan, Santos, Jose, Goldman, Jason, Tuttle, Katherine, Teixeira, J, Seibert, Allan, Koullias, Yiannis, Llewellyn, Joe, Regan, Sean, Zhao, Yang, Huang, Hailin, Hyland, Robert, Osinusi, Anu, Winter, Helen, Humeniuk, Rita, Hulter, Henry, Gottlieb, Robert, Fusco, Dahlene, Birne, Rita, Stancampiano, Fernando, Libertin, Claudia, Small, Catherine, Plate, Markus, and McPhail, Mark

Subjects
COVID-19, SARS-CoV-2, kidney impairment, remdesivir, Humans, Alanine, Adenosine Monophosphate, Male, Female, Middle Aged, COVID-19 Drug Treatment, Antiviral Agents, Double-Blind Method, Aged, SARS-CoV-2, COVID-19, Hospitalization, Acute Kidney Injury, Adult, Treatment Outcome, Respiration, Artificial, Aged, 80 and over
Abstract

BACKGROUND: Few antiviral therapies have been studied in patients with coronavirus disease 2019 (COVID-19) and kidney impairment. Herein, the efficacy, safety, and pharmacokinetics of remdesivir, its metabolites, and sulfobutylether-β-cyclodextrin excipient were evaluated in hospitalized patients with COVID-19 and severe kidney impairment. METHODS: In REDPINE, a phase 3, randomized, double-blind, placebo-controlled study, participants aged ≥12 years hospitalized for COVID-19 pneumonia with acute kidney injury, chronic kidney disease, or kidney failure were randomized 2:1 to receive intravenous remdesivir (200 mg on day 1; 100 mg daily up to day 5) or placebo (enrollment from March 2021 to March 2022). The primary efficacy end point was the composite of the all-cause mortality rate or invasive mechanical ventilation rate through day 29. Safety was evaluated through day 60. RESULTS: Although enrollment concluded early, 243 participants were enrolled and treated (remdesivir, n = 163; placebo, n = 80). At baseline, 90 participants (37.0%) had acute kidney injury (remdesivir, n = 60; placebo, n = 30), 64 (26.3%) had chronic kidney disease (remdesivir, n = 44; placebo, n = 20), and 89 (36.6%) had kidney failure (remdesivir, n = 59; placebo, n = 30); and 31 (12.8%) were vaccinated against COVID-19. Composite all-cause mortality or invasive mechanical ventilation rates through day 29 were 29.4% and 32.5% in the remdesivir and placebo group, respectively (P = .61). Treatment-emergent adverse events were reported in 80.4% for remdesivir versus 77.5% for placebo, and serious adverse events in 50.3% versus 50.0%, respectively. Pharmacokinetic plasma exposure to remdesivir was not affected by kidney function. CONCLUSIONS: Although the study was underpowered, no significant difference in efficacy was observed between treatment groups. REDPINE demonstrated that remdesivir is safe in patients with COVID-19 and severe kidney impairment. CLINICAL TRIALS REGISTRATION: EudraCT 2020-005416-22; Clinical Trials.gov NCT04745351.

Published
2024

31. Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases.

Author

Rosain, Jérémie, Le Voyer, Tom, Liu, Xian, Gervais, Adrian, Polivka, Laura, Cederholm, Axel, Berteloot, Laureline, Parent, Audrey, Pescatore, Alessandra, Spinosa, Ezia, Minic, Snezana, Kiszewski, Ana, Tsumura, Miyuki, Thibault, Chloé, Esnaola Azcoiti, Maria, Martinovic, Jelena, Philippot, Quentin, Khan, Taushif, Marchal, Astrid, Charmeteau-De Muylder, Bénédicte, Bizien, Lucy, Deswarte, Caroline, Hadjem, Lillia, Fauvarque, Marie-Odile, Dorgham, Karim, Eriksson, Daniel, Falcone, Emilia, Puel, Mathilde, Ünal, Sinem, Geraldo, Amyrath, Le Floch, Corentin, Li, Hailun, Rheault, Sylvie, Muti, Christine, Bobrie-Moyrand, Claire, Welfringer-Morin, Anne, Fuleihan, Ramsay, Lévy, Romain, Roelens, Marie, Gao, Liwei, Materna, Marie, Pellegrini, Silvia, Piemonti, Lorenzo, Catherinot, Emilie, Goffard, Jean-Christophe, Fekkar, Arnaud, Sacko-Sow, Aissata, Soudée, Camille, Boucherit, Soraya, Neehus, Anna-Lena, Has, Cristina, Hübner, Stefanie, Blanchard-Rohner, Géraldine, Amador-Borrero, Blanca, Utsumi, Takanori, Taniguchi, Maki, Tani, Hiroo, Izawa, Kazushi, Yasumi, Takahiro, Kanai, Sotaro, Migaud, Mélanie, Aubart, Mélodie, Lambert, Nathalie, Gorochov, Guy, Picard, Capucine, Soudais, Claire, LHonneur, Anne-Sophie, Rozenberg, Flore, Milner, Joshua, Zhang, Shen-Ying, Vabres, Pierre, Trpinac, Dusan, Marr, Nico, Boddaert, Nathalie, Desguerre, Isabelle, Pasparakis, Manolis, Miller, Corey, Poziomczyk, Cláudia, Abel, Laurent, Okada, Satoshi, Jouanguy, Emmanuelle, Cheynier, Rémi, Zhang, Qian, Cobat, Aurélie, Béziat, Vivien, Boisson, Bertrand, Steffann, Julie, Fusco, Francesca, Ursini, Matilde, Hadj-Rabia, Smail, Bodemer, Christine, Bustamante, Jacinta, Luche, Hervé, Puel, Anne, Courtois, Gilles, Bastard, Paul, Landegren, Nils, Anderson, Mark, and Casanova, Jean-Laurent

Subjects
Humans, Interferon Type I, Female, Autoantibodies, Thymus Gland, Child, Incontinentia Pigmenti, Child, Preschool, I-kappa B Kinase, Virus Diseases, Infant, Adult, Adolescent, Young Adult
Abstract

Human inborn errors of thymic T cell tolerance underlie the production of autoantibodies (auto-Abs) neutralizing type I IFNs, which predispose to severe viral diseases. We analyze 131 female patients with X-linked dominant incontinentia pigmenti (IP), heterozygous for loss-of-function (LOF) NEMO variants, from 99 kindreds in 10 countries. Forty-seven of these patients (36%) have auto-Abs neutralizing IFN-α and/or IFN-ω, a proportion 23 times higher than that for age-matched female controls. This proportion remains stable from the age of 6 years onward. On imaging, female patients with IP have a small, abnormally structured thymus. Auto-Abs against type I IFNs confer a predisposition to life-threatening viral diseases. By contrast, patients with IP lacking auto-Abs against type I IFNs are at no particular risk of viral disease. These results suggest that IP accelerates thymic involution, thereby underlying the production of auto-Abs neutralizing type I IFNs in at least a third of female patients with IP, predisposing them to life-threatening viral diseases.

Published
2024

32. Stochastically Structured Illumination Microscopy scan less super resolution imaging

Author

Fusco, Denzel, Xypakis, Emmanouil, Gigante, Ylenia, Mautone, Lorenza, Di Angelantonio, Silvia, Ponsi, Giorgia, Ruocco, Giancarlo, and Leonetti, Marco

Subjects
Physics - Optics, 92C55, 78A70
Abstract

In Super-resolution, a varying-illumination image stack is required. This enriched the dataset typically necessitates precise mechanical control and micron scale optical alignment and repeatability. Here, we introduce a novel methodology for super-resolution microscopy called Stochastically Structured Illumination Microscopy (S2IM), which bypasses the need for illumination control instead exploiting the random, uncontrolled movement of the target object. We tested our methodology within the clinically relevant ophthalmoscopic setting, harnessing the inherent saccadic motion of the eye to induce stochastic displacement of the illumination pattern on the retina. We opted to avoid human subjects by utilizing a phantom eye model, featuring a retina composed of human induced pluripotent stem cells (iPSC) retinal neurons, and replicating the ocular saccadic movements by custom actuators. Our findings demonstrate that S$^2$IM unlocks scan-less super-resolution with a resolution enhancement of 1.91, with promising prospects also beyond ophthalmoscopy applications such as active matter or atmospheric/astronomical observation.

Published
2024

33. RISTRETTO: a VLT XAO design to reach Proxima Cen b in the visible

Author

Blind, N., Shinde, M., Dinis, I., Restori, N., Chazelas, B., Fusco, T., Guyon, O., Kuehn, J., Lovis, C., Martinez, P., Motte, M., Sauvage, J. -F., and Spang, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

RISTRETTO is the evolution of the original idea of coupling the VLT instruments SPHERE and ESPRESSO \cite{lovis_2016a}, aiming at High Dispersion Coronagraphy. RISTRETTO is a visitor instrument that should enable the characterization of the atmospheres of nearby exoplanets in reflected light, by using the technique of high-contrast, high-resolution spectroscopy. Its goal is to observe Prox Cen b and other planets placed at about 35mas from their star, i.e. $2\lambda/D$ at $\lambda$=750nm. The instrument is composed of an extreme adaptive optics, a coronagraphic Integral Field Unit, and a diffraction-limited spectrograph (R=140.000, $\lambda =$620-840 nm). We present the RISTRETTO XAO architecture that reach the specification, providing contrasts down to $5\times10^{-5}$ at 2$\lambda/D$ from the star in the visible, in the presence of atmosphere and low wind effect. This performance is allowed by a new two-sensors-one-dm architecture, some variations to the already known concepts of unmodulated pyWFS and zWFS, and exploiting to the maximum of their capabilities the state-of-the-art high speed, low noise cameras \& fast DM. We present the result of end-to-end simulations, that demonstrate stable closed loop operation of an unmodulated pyramid and a zernike WFS (together), and in presence of low wind effect., Comment: 13 pages, 12 figure, SPIE Astronomical Telescopes + Instrumentation, 2024, Yokohama, Japan

Published
2024
Full Text
View/download PDF

34. Selling Joint Ads: A Regret Minimization Perspective

Author

Aggarwal, Gagan, Badanidiyuru, Ashwinkumar, Dütting, Paul, and Fusco, Federico

Subjects
Computer Science - Computer Science and Game Theory, Computer Science - Machine Learning
Abstract

Motivated by online retail, we consider the problem of selling one item (e.g., an ad slot) to two non-excludable buyers (say, a merchant and a brand). This problem captures, for example, situations where a merchant and a brand cooperatively bid in an auction to advertise a product, and both benefit from the ad being shown. A mechanism collects bids from the two and decides whether to allocate and which payments the two parties should make. This gives rise to intricate incentive compatibility constraints, e.g., on how to split payments between the two parties. We approach the problem of finding a revenue-maximizing incentive-compatible mechanism from an online learning perspective; this poses significant technical challenges. First, the action space (the class of all possible mechanisms) is huge; second, the function that maps mechanisms to revenue is highly irregular, ruling out standard discretization-based approaches. In the stochastic setting, we design an efficient learning algorithm achieving a regret bound of $O(T^{3/4})$. Our approach is based on an adaptive discretization scheme of the space of mechanisms, as any non-adaptive discretization fails to achieve sublinear regret. In the adversarial setting, we exploit the non-Lipschitzness of the problem to prove a strong negative result, namely that no learning algorithm can achieve more than half of the revenue of the best fixed mechanism in hindsight. We then consider the $\sigma$-smooth adversary; we construct an efficient learning algorithm that achieves a regret bound of $O(T^{2/3})$ and builds on a succinct encoding of exponentially many experts. Finally, we prove that no learning algorithm can achieve less than $\Omega(\sqrt T)$ regret in both the stochastic and the smooth setting, thus narrowing the range where the minimax regret rates for these two problems lie., Comment: Paper accepted at ACM EC 2024

Published
2024

35. GRB 221009A: the B.O.A.T Burst that Shines in Gamma Rays

Author

Axelsson, M., Ajello, M., Arimoto, M., Baldini, L., Ballet, J., Baring, M. G., Bartolini, C., Bastieri, D., Gonzalez, J. Becerra, Bellazzini, R., Berenji, B., Bissaldi, E., Blandford, R. D., Bonino, R., Bruel, P., Buson, S., Cameron, R. A., Caputo, R., Caraveo, P. A., Cavazzuti, E., Cheung, C. C., Chiaro, G., Cibrario, N., Ciprini, S., Cozzolongo, G., Orestano, P. Cristarella, Crnogorcevic, M., Cuoco, A., Cutini, S., D'Ammando, F., De Gaetano, S., Di Lalla, N., Dinesh, A., Di Tria, R., Di Venere, L., Domínguez, A., Fegan, S. J., Ferrara, E. C., Fiori, A., Franckowiak, A., Fukazawa, Y., Funk, S., Fusco, P., Galanti, G., Gargano, F., Gasbarra, C., Germani, S., Giacchino, F., Giglietto, N., Giliberti, M., Gill, R., Giordano, F., Giroletti, M., Granot, J., Green, D., Grenier, I. A., Guiriec, S., Gustafsson, M., Hashizume, M., Hays, E., Hewitt, J. W., Horan, D., Kayanoki, T., Kuss, M., Laviron, A., Li, J., Liodakis, I., Longo, F., Loparco, F., Lorusso, L., Lott, B., Lovellette, M. N., Lubrano, P., Maldera, S., Malyshev, D., Manfreda, A., Martí-Devesa, G., Martinelli, R., Castellanos, I. Martinez, Mazziotta, M. N., McEnery, J. E., Mereu, I., Meyer, M., Michelson, P. F., Mirabal, N., Mitthumsiri, W., Mizuno, T., Monti-Guarnieri, P., Monzani, M. E., Morishita, T., Morselli, A., Moskalenko, I. V., Negro, M., Niwa, R., Omodei, N., Orienti, M., Orlando, E., Paneque, D., Panzarini, G., Persic, M., Pesce-Rollins, M., Petrosian, V., Pillera, R., Piron, F., Porter, T. A., Principe, G., Racusin, J. L., Rainò, S., Rando, R., Rani, B., Razzano, M., Razzaque, S., Reimer, A., Reimer, O., Ryde, F., Sánchez-Conde, M., Parkinson, P. M. Saz, Serini, D., Sgrò, C., Sharma, V., Siskind, E. J., Spandre, G., Spinelli, P., Suson, D. J., Tajima, H., Tak, D., Thayer, J. B., Torres, D. F., Valverde, J., Zaharijas, G., Lesage, S., Briggs, M. S., Burns, E., Bala, S., Bhat, P. N., Cleveland, W. H., Dalessi, S., de Barra, C., Gibby, M., Giles, M. M., Hamburg, R., Hristov, B. A., Hui, C. M., Kocevski, D., Mailyan, B., Malacaria, C., McBreen, S., Poolakkil, S., Roberts, O. J., Scotton, L., Veres, P., von Kienlin, A., Wilson-Hodge, C. A., and Wood, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present a complete analysis of Fermi Large Area Telescope (LAT) data of GRB 221009A, the brightest Gamma-Ray Burst (GRB) ever detected. The burst emission above 30 MeV detected by the LAT preceded by 1 s the low-energy (< 10 MeV) pulse that triggered the Fermi Gamma-Ray Burst Monitor (GBM), as has been observed in other GRBs. The prompt phase of GRB 221009A lasted a few hundred seconds. It was so bright that we identify a Bad Time Interval (BTI) of 64 seconds caused by the extremely high flux of hard X-rays and soft gamma rays, during which the event reconstruction efficiency was poor and the dead time fraction quite high. The late-time emission decayed as a power law, but the extrapolation of the late-time emission during the first 450 seconds suggests that the afterglow started during the prompt emission. We also found that high-energy events observed by the LAT are incompatible with synchrotron origin, and, during the prompt emission, are more likely related to an extra component identified as synchrotron self-Compton (SSC). A remarkable 400 GeV photon, detected by the LAT 33 ks after the GBM trigger and directionally consistent with the location of GRB 221009A, is hard to explain as a product of SSC or TeV electromagnetic cascades, and the process responsible for its origin is uncertain. Because of its proximity and energetic nature, GRB 221009A is an extremely rare event., Comment: 60 pages, 38 figures, 9 tables

Published
2024

36. RISTRETTO: reflected-light exoplanet spectroscopy at the diffraction limit of the VLT

Author

Lovis, Christophe, Blind, Nicolas, Chazelas, Bruno, Shinde, Muskan, Bugatti, Maddalena, Restori, Nathanaël, Dinis, Isaac, Genolet, Ludovic, Hughes, Ian, Sordet, Michaël, Schnell, Robin, Rihs, Samuel, Crausaz, Adrien, Turbet, Martin, Billot, Nicolas, Fusco, Thierry, Neichel, Benoit, Sauvage, Jean-François, Diaz, Pablo Santos, Houelle, Mathilde, Blackman, Joshua, Lanotte, Audrey, Kühn, Jonas, Hagelberg, Janis, Guyon, Olivier, Martinez, Patrice, Spang, Alain, Mordasini, Christoph, Ehrenreich, David, Demory, Brice-Olivier, and Bolmont, Emeline

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

RISTRETTO is a visible high-resolution spectrograph fed by an extreme adaptive optics (AO) system, to be proposed as a visitor instrument on ESO VLT. The main science goal of RISTRETTO is to pioneer the detection and atmospheric characterisation of exoplanets in reflected light, in particular the temperate rocky planet Proxima b. RISTRETTO will be able to measure albedos and detect atmospheric features in a number of exoplanets orbiting nearby stars for the first time. It will do so by combining a high-contrast AO system working at the diffraction limit of the telescope to a high-resolution spectrograph, via a 7-spaxel integral-field unit (IFU) feeding single-mode fibers. Further science cases for RISTRETTO include the study of accreting protoplanets such as PDS70b/c through spectrally-resolved H-alpha emission, and spatially-resolved studies of Solar System objects such as icy moons and the ice giants Uranus and Neptune. The project is in the manufacturing phase for the spectrograph sub-system, and the preliminary design phase for the AO front-end. Specific developments for RISTRETTO include a novel coronagraphic IFU combining a phase-induced amplitude apodizer (PIAA) to a 3D-printed microlens array feeding a bundle of single-mode fibers. It also features an XAO system with a dual wavefront sensor aiming at high robustness and sensitivity, including to pupil fragmentation. RISTRETTO is a pathfinder instrument in view of similar developments at the ELT, in particular the SCAO-IFU mode of ELT-ANDES and the future ELT-PCS instrument., Comment: 6 pages, 1 figure, SPIE Astronomical Telescopes + Instrumentation, 2024, Yokohama, Japan

Published
2024
Full Text
View/download PDF

37. Optimal Control Problems with Vector-Valued Impulse Controls and Time Delays

Author

Fusco, Giovanni, Motta, Monica, and Vinter, Richard

Subjects
Mathematics - Optimization and Control, 49N25, 93C43, 49K21, 26A45, 49J21
Abstract

We consider a nonlinear control system with vector-valued measures as controls and with dynamics depending on time delayed states. First, we introduce a notion of discontinuous, bounded variation solution associated with this system and establish an equivalent representation formula for it, inspired by the approach known in delay-free impulsive control as the `graph completions' method. Then, thanks to this equivalent formulation, we prove well-posedness properties of these solutions and also derive necessary optimality conditions in the form of a Maximum Principle for an associated minimization problem.

Published
2024

38. Hadronic cross section measurements with the DAMPE space mission using 20GeV-10TeV cosmic-ray protons and $^4$He

Author

Alemanno, F., An, Q., Azzarello, P., Barbato, F. C. T., Bernardini, P., Bi, X. J., Cagnoli, I., Cai, M. S., Casilli, E., Catanzani, E., Chang, J., Chen, D. Y., Chen, J. L., Chen, Z. F., Coppin, P., Cui, M. Y., Cui, T. S., Cui, Y. X., Dai, H. T., De Benedittis, A., De Mitri, I., de Palma, F., Di Giovanni, A., Ding, Q., Dong, T. K., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., Fan, R. R., Fan, Y. Z., Fang, F., Fang, K., Feng, C. Q., Feng, L., Frieden, J. M., Fusco, P., Gao, M., Gargano, F., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, L. Y., Jiang, Y. Z., Jiang, W., Kong, J., Kotenko, A., Kyratzis, D., Lei, S. J., Li, W. H., Li, W. L., Li, X., Li, X. Q., Liang, Y. M., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, Y., Loparco, F., Luo, C. N., Ma, M., Ma, P. X., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Pan, X., Parenti, A., Peng, W. X., Peng, X. Y., Perrina, C., Putti-Garcia, E., Qiao, R., Rao, J. N., Ruina, A., Sarkar, R., Savina, P., Serpolla, A., Shangguan, Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Silveri, L., Song, J. X., Stolpovskiy, M., Su, H., Su, M., Sun, H. R., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Wang, J. Z., Wang, L. G., Wang, S., Wang, S. X., Wang, X. L., Wang, Y., Wang, Y. F., Wang, Y. Z., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, S. S., Wu, X., Xia, Z. Q., Xu, H. T., Xu, J., Xu, Z. H., Xu, Z. L., Xu, E. H., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yao, H. J., Yu, Y. H., Yuan, G. W., Yuan, Q., Yue, C., Zang, J. J., Zhang, S. X., Zhang, W. Z., Zhang, Yan, Zhang, Yi, Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, C., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., and Zhu, Y.

Subjects
High Energy Physics - Experiment
Abstract

Precise direct cosmic-ray (CR) measurements provide an important probe to study the energetic particle sources in our Galaxy, and the interstellar environment through which these particles propagate. Uncertainties on hadronic models, ion-nucleon cross sections in particular, are currently the limiting factor towards obtaining more accurate CR ion flux measurements with calorimetric space-based experiments. We present an energy-dependent measurement of the inelastic cross section of protons and helium-4 nuclei (alpha particles) on a Bi$_4$Ge$_3$O$_{12}$ target, using 88 months of data collected by the DAMPE space mission. The kinetic energy range per nucleon of the measurement points ranges from 18 GeV to 9 TeV for protons, and from 5 GeV/n to 3 TeV/n for helium-4 nuclei. Our results lead to a significant improvement of the CR flux normalisation. In the case of helium-4, these results correspond to the first cross section measurements on a heavy target material at energies above 10 GeV/n., Comment: Published in PRD

Published
2024
Full Text
View/download PDF

39. Exploring GPU-to-GPU Communication: Insights into Supercomputer Interconnects

Author

De Sensi, Daniele, Pichetti, Lorenzo, Vella, Flavio, De Matteis, Tiziano, Ren, Zebin, Fusco, Luigi, Turisini, Matteo, Cesarini, Daniele, Lust, Kurt, Trivedi, Animesh, Roweth, Duncan, Spiga, Filippo, Di Girolamo, Salvatore, and Hoefler, Torsten

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Artificial Intelligence, Computer Science - Hardware Architecture, Computer Science - Networking and Internet Architecture, Computer Science - Performance, C.2.4, C.5.1, C.2.1, C.4
Abstract

Multi-GPU nodes are increasingly common in the rapidly evolving landscape of exascale supercomputers. On these systems, GPUs on the same node are connected through dedicated networks, with bandwidths up to a few terabits per second. However, gauging performance expectations and maximizing system efficiency is challenging due to different technologies, design options, and software layers. This paper comprehensively characterizes three supercomputers - Alps, Leonardo, and LUMI - each with a unique architecture and design. We focus on performance evaluation of intra-node and inter-node interconnects on up to 4096 GPUs, using a mix of intra-node and inter-node benchmarks. By analyzing its limitations and opportunities, we aim to offer practical guidance to researchers, system architects, and software developers dealing with multi-GPU supercomputing. Our results show that there is untapped bandwidth, and there are still many opportunities for optimization, ranging from network to software optimization.

Published
2024
Full Text
View/download PDF

40. Understanding Data Movement in Tightly Coupled Heterogeneous Systems: A Case Study with the Grace Hopper Superchip

Author

Fusco, Luigi, Khalilov, Mikhail, Chrapek, Marcin, Chukkapalli, Giridhar, Schulthess, Thomas, and Hoefler, Torsten

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing
Abstract

Heterogeneous supercomputers have become the standard in HPC. GPUs in particular have dominated the accelerator landscape, offering unprecedented performance in parallel workloads and unlocking new possibilities in fields like AI and climate modeling. With many workloads becoming memory-bound, improving the communication latency and bandwidth within the system has become a main driver in the development of new architectures. The Grace Hopper Superchip (GH200) is a significant step in the direction of tightly coupled heterogeneous systems, in which all CPUs and GPUs share a unified address space and support transparent fine grained access to all main memory on the system. We characterize both intra- and inter-node memory operations on the Quad GH200 nodes of the new Swiss National Supercomputing Centre Alps supercomputer, and show the importance of careful memory placement on example workloads, highlighting tradeoffs and opportunities.

Published
2024

41. Measurement of neutrino oscillation parameters with the first six detection units of KM3NeT/ORCA

Author

KM3NeT Collaboration, Aiello, S., Albert, A., Alhebsi, A. R., Alshamsi, M., Garre, S. Alves, Ambrosone, A., Ameli, F., Andre, M., Aphecetche, L., Ardid, M., Ardid, S., Atmani, H., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardačová, Z., Baret, B., Bariego-Quintana, A., Becherini, Y., Bendahman, M., Benfenati, F., Benhassi, M., Bennani, M., Benoit, D. M., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bonanno, D., Bouasla, A. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Brânzaş, H., Bretaudeau, F., Breuhaus, M., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carenini, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chen, A., Cherubini, S., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Condorelli, A., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Benedittis, A., De Martino, B., De Wasseige, G., Decoene, V., Del Rosso, I., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drakopoulou, E., Drouhin, D., Ducoin, J. -G., Dvornický, R., Eberl, T., Eckerová, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Ellajosyula, V., Enzenhöfer, A., Ferrara, G., Filipović, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gagliardini, S., Gal, T., Méndez, J. García, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Genton, E., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Gozzini, S. R., Gracia, R., Guidi, C., Guillon, B., Gutiérrez, M., Haack, C., van Haren, H., Heijboer, A., Hennig, L., Hernández-Rey, J. J., Ibnsalih, W. Idrissi, Illuminati, G., Joly, D., de Jong, M., de Jong, P., Jung, B. J., Kistauri, G., Kopper, C., Kouchner, A., Kovalev, Y. Y., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Stum, S. Le, Lehaut, G., Lemaítre, V., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Longhitano, F., Magnani, F., Majumdar, J., Malerba, L., Mamedov, F., Mańczak, J., Manfreda, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Mastrodicasa, M., Mastroianni, S., Mauro, J., Miele, G., Migliozzi, P., Migneco, E., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Moussa, A., Mateo, I. Mozun, Muller, R., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, Oliviero, V., Orlando, A., Oukacha, E., Paesani, D., González, J. Palacios, Papalashvili, G., Parisi, V., Gomez, E. J. Pastor, Păun, A. M., Păvălaş, G. E., Martínez, S. Peña, Perrin-Terrin, M., Pestel, V., Pestes, R., Piattelli, P., Plavin, A., Poirè, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quiroz-Rangel, C. A., Randazzo, N., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Robinson, J., Romanov, A., Ros, E., Šaina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanfilippo, S., Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Šimkovic, F., Simonelli, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Štekl, I., Stellacci, S. M., Taiuti, M., Tayalati, Y., Thiersen, H., Thoudam, S., Melo, I. Tosta e, Trocmé, B., Tsourapis, V., Tudorache, A., Tzamariudaki, E., Ukleja, A., Vacheret, A., Valsecchi, V., Van Elewyck, V., Vannoye, G., Vasileiadis, G., de Sola, F. Vazquez, Veutro, A., Viola, S., Vivolo, D., van Vliet, A., de Wolf, E., Yvon, I., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Subjects
High Energy Physics - Experiment
Abstract

KM3NeT/ORCA is a water Cherenkov neutrino detector under construction and anchored at the bottom of the Mediterranean Sea. The detector is designed to study oscillations of atmospheric neutrinos and determine the neutrino mass ordering. This paper focuses on an initial configuration of ORCA, referred to as ORCA6, which comprises six out of the foreseen 115 detection units of photo-sensors. A high-purity neutrino sample was extracted, corresponding to an exposure of 433 kton-years. The sample of 5828 neutrino candidates is analysed following a binned log-likelihood method in the reconstructed energy and cosine of the zenith angle. The atmospheric oscillation parameters are measured to be $\sin^2\theta_{23}= 0.51^{+0.04}_{-0.05}$, and $ \Delta m^2_{31} = 2.18^{+0.25}_{-0.35}\times 10^{-3}~\mathrm{eV^2} \cup \{-2.25,-1.76\}\times 10^{-3}~\mathrm{eV^2}$ at 68\% CL. The inverted neutrino mass ordering hypothesis is disfavoured with a p-value of 0.25., Comment: 29 pages, 12 figures

Published
2024

42. Online Learning with Sublinear Best-Action Queries

Author

Russo, Matteo, Celli, Andrea, Baldeschi, Riccardo Colini, Fusco, Federico, Haimovich, Daniel, Karamshuk, Dima, Leonardi, Stefano, and Tax, Niek

Subjects
Computer Science - Machine Learning
Abstract

In online learning, a decision maker repeatedly selects one of a set of actions, with the goal of minimizing the overall loss incurred. Following the recent line of research on algorithms endowed with additional predictive features, we revisit this problem by allowing the decision maker to acquire additional information on the actions to be selected. In particular, we study the power of \emph{best-action queries}, which reveal beforehand the identity of the best action at a given time step. In practice, predictive features may be expensive, so we allow the decision maker to issue at most $k$ such queries. We establish tight bounds on the performance any algorithm can achieve when given access to $k$ best-action queries for different types of feedback models. In particular, we prove that in the full feedback model, $k$ queries are enough to achieve an optimal regret of $\Theta\left(\min\left\{\sqrt T, \frac Tk\right\}\right)$. This finding highlights the significant multiplicative advantage in the regret rate achievable with even a modest (sublinear) number $k \in \Omega(\sqrt{T})$ of queries. Additionally, we study the challenging setting in which the only available feedback is obtained during the time steps corresponding to the $k$ best-action queries. There, we provide a tight regret rate of $\Theta\left(\min\left\{\frac{T}{\sqrt k},\frac{T^2}{k^2}\right\}\right)$, which improves over the standard $\Theta\left(\frac{T}{\sqrt k}\right)$ regret rate for label efficient prediction for $k \in \Omega(T^{2/3})$.

Published
2024

43. Advancements in Traffic Processing Using Programmable Hardware Flow Offload

Author

Deri, Luca, Cardigliano, Alfredo, and Fusco, Francesco

Subjects
Computer Science - Networking and Internet Architecture
Abstract

The exponential growth of data traffic and the increasing complexity of networked applications demand effective solutions capable of passively inspecting and analysing the network traffic for monitoring and security purposes. Implementing network probes in software using general-purpose operating systems has been made possible by advances in packet-capture technologies, such as kernel-bypass frameworks, and by multi-queue adapters designed to distribute the network workload in multi-core processors. Modern SmartNICs, in addition, have introduced stateful mechanisms to associate actions to network flows such as forwarding packets or updating traffic statistics for an individual flow. In this paper, we describe our experience in exploiting those functionalities in a modern network probe and we perform a detailed study of the performance characteristics under different scenarios. Compared to pure CPU-based solutions, SmartNICs with flow-offload technologies provide substantial benefits when implementing forwarding applications. However, the main limitation of having to keep large flow tables in the host memory remains largely unsolved for realistic monitoring and security applications., Comment: Presented at NetCell-AI workshop part of IEEE HPSR 2024, https://hpsr2024.ieee-hpsr.org/

Published
2024

44. Pandora's Box Problem Over Time

Author

Amanatidis, Georgios, Fusco, Federico, Reiffenhäuser, Rebecca, and Tsikiridis, Artem

Subjects
Computer Science - Computer Science and Game Theory, Computer Science - Data Structures and Algorithms, Mathematics - Probability
Abstract

The Pandora's Box problem models the search for the best alternative when evaluation is costly. In its simplest variant, a decision maker is presented with $n$ boxes, each associated with a cost of inspection and a distribution over the reward hidden within. The decision maker inspects a subset of these boxes one after the other, in a possibly adaptive ordering, and obtains as utility the difference between the largest reward uncovered and the sum of the inspection costs. While this classic version of the problem is well understood (Weitzman 1979), recent years have seen a flourishing of the literature on variants of the problem. In this paper, we introduce a general framework -- the Pandora's Box Over Time problem -- that captures a wide range of variants where time plays a role, e.g., as it might constrain the schedules of exploration and influence both costs and rewards. In the Pandora's Box Over Time problem, each box is characterized by time-dependent rewards and costs, and inspecting it might require a box-specific processing time. Moreover, once a box is inspected, its reward may deteriorate over time, possibly differently for each box. Our main result is an efficient $21.3$-approximation to the optimal strategy, which is NP-hard to compute in general. We further obtain improved results for the natural special cases where boxes have no processing time, or when costs and reward distributions do not depend on time (but rewards may deteriorate after inspecting).

Published
2024

45. ANDES, the high resolution spectrograph for the ELT: science goals, project overview and future developments

Author

Marconi, A., Abreu, M., Adibekyan, V., Alberti, V., Albrecht, S., Alcaniz, J., Aliverti, M., Prieto, C. Allende, Gómez, J. D. Alvarado, Alves, C. S., Amado, P. J., Amate, M., Andersen, M. I., Antoniucci, S., Artigau, E., Bailet, C., Baker, C., Baldini, V., Balestra, A., Barnes, S. A., Baron, F., Barros, S. C. C., Bauer, S. M., Beaulieu, M., Bellido-Tirado, O., Benneke, B., Bensby, T., Bergin, E. A., Berio, P., Biazzo, K., Bigot, L., Bik, A., Birkby, J. L., Blind, N., Boebion, O., Boisse, I., Bolmont, E., Bolton, J. S., Bonaglia, M., Bonfils, X., Bonhomme, L., Borsa, F., Bouret, J. -C., Brandeker, A., Brandner, W., Broeg, C. H., Brogi, M., Brousseau, D., Brucalassi, A., Brynnel, J., Buchhave, L. A., Buscher, D. F., Cabona, L., Cabral, A., Calderone, G., Calvo-Ortega, R., Cantalloube, F., Martins, B. L. Canto, Carbonaro, L., Caujolle, Y., Chauvin, G., Chazelas, B., Cheffot, A. -L., Cheng, Y. S., Chiavassa, A., Christensen, L., Cirami, R., Cirasuolo, M., Cook, N. J., Cooke, R. J., Coretti, I., Covino, S., Cowan, N., Cresci, G., Cristiani, S., Parro, V. Cunha, Cupani, G., D'Odorico, V., Dadi, K., Leão, I. de Castro, De Cia, A., De Medeiros, J. R., Debras, F., Debus, M., Delorme, A., Demangeon, O., Derie, F., Dessauges-Zavadsky, M., Di Marcantonio, P., Di Stefano, S., Dionies, F., de Souza, A. Domiciano, Doyon, R., Dunn, J., Egner, S., Ehrenreich, D., Faria, J. P., Ferruzzi, D., Feruglio, C., Fisher, M., Fontana, A., Frank, B. S., Fuesslein, C., Fumagalli, M., Fusco, T., Fynbo, J., Gabella, O., Gaessler, W., Gallo, E., Gao, X., Genolet, L., Genoni, M., Giacobbe, P., Giro, E., Goncalves, R. S., Gonzalez, O. A., Hernández, J. I. González, Gouvret, C., Temich, F. Gracia, Haehnelt, M. G., Haniff, C., Hatzes, A., Helled, R., Hoeijmakers, H. J., Hughes, I., Huke, P., Ivanisenko, Y., Järvinen, A. S., Järvinen, S. P., Kaminski, A., Kern, J., Knoche, J., Kordt, A., Korhonen, H., Korn, A. J., Kouach, D., Kowzan, G., Kreidberg, L., Landoni, M., Lanotte, A. A., Lavail, A., Lavie, B., Lee, D., Lehmitz, M., Li, J., Li, W., Liske, J., Lovis, C., Lucatello, S., Lunney, D., MacIntosh, M. J., Madhusudhan, N., Magrini, L., Maiolino, R., Maldonado, J., Malo, L., Man, A. W. S., Marquart, T., Marques, C. M. J., Marques, E. L., Martinez, P., Martins, A., Martins, C. J. A. P., Martins, J. H. C., Maslowski, P., Mason, C. A., Mason, E., McCracken, R. A., Sousa, M. A. F. Melo e, Mergo, P., Micela, G., Milaković, D., Molliere, P., Monteiro, M. A., Montgomery, D., Mordasini, C., Morin, J., Mucciarelli, A., Murphy, M. T., N'Diaye, M., Nardetto, N., Neichel, B., Neri, N., Niedzielski, A. T., Niemczura, E., Nisini, B., Nortmann, L., Noterdaeme, P., Nunes, N. J., Oggioni, L., Olchewsky, F., Oliva, E., Onel, H., Origlia, L., Ostlin, G., Ouellette, N. N. -Q., Palle, E., Papaderos, P., Pariani, G., Pasquini, L., Castro, J. Peñate, Pepe, F., Peroux, C., Levasseur, L. Perreault, Perruchot, S., Petit, P., Pfuhl, O., Pino, L., Piqueras, J., Piskunov, N., Pollo, A., Poppenhaeger, K., Porru, M., Puschnig, J., Quirrenbach, A., Rauscher, E., Rebolo, R., Redaelli, E. M. A., Reffert, S., Reid, D. T., Reiners, A., Richter, P., Riva, M., Rivoire, S., Rodriguez-López, C., Roederer, I. U., Romano, D., Roth, M., Rousseau, S., Rowe, J., Saccardi, A., Salvadori, S., Sanna, N., Santos, N. C., Diaz, P. Santos, Sanz-Forcada, J., Sarajlic, M., Sauvage, J. -F., Savio, D., Scaudo, A, Schäfer, S., Schiavon, R. P., Schmidt, T. M., Selmi, C., Simoes, R., Simonnin, A., Sivanandam, S., Sordet, M., Sordo, R., Sortino, F., Sosnowska, D., Sousa, S. G., Spang, A., Spiga, R., Stempels, E., Stevenson, J. R. Y., Strassmeier, K. G., Mascareño, A. Suárez, Sulich, A., Sun, X., Tanvir, N. R., Tenegi-Sangines, F., Thibault, S., Thompson, S. J., Tisserand, P., Tozzi, A., Turbet, M., Veran, J. -P., Vallee, P., Vanni, I., Varas, R., Vega-Moreno, A., Venn, K. A., Verma, A., Vernet, J., Viel, M., Wade, G., Waring, C., Weber, M., Weder, J., Wehbe, B., Weingrill, J., Woche, M., Xompero, M., Zackrisson, E., Zanutta, A., Osorio, M. R. Zapatero, Zechmeister, M., and Zimara, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The first generation of ELT instruments includes an optical-infrared high-resolution spectrograph, indicated as ELT-HIRES and recently christened ANDES (ArmazoNes high Dispersion Echelle Spectrograph). ANDES consists of three fibre-fed spectrographs ([U]BV, RIZ, YJH) providing a spectral resolution of $\sim$100,000 with a minimum simultaneous wavelength coverage of 0.4-1.8 $\mu$m with the goal of extending it to 0.35-2.4 $\mu$m with the addition of a U arm to the BV spectrograph and a separate K band spectrograph. It operates both in seeing- and diffraction-limited conditions and the fibre feeding allows several, interchangeable observing modes including a single conjugated adaptive optics module and a small diffraction-limited integral field unit in the NIR. Modularity and fibre-feeding allow ANDES to be placed partly on the ELT Nasmyth platform and partly in the Coud\'e room. ANDES has a wide range of groundbreaking science cases spanning nearly all areas of research in astrophysics and even fundamental physics. Among the top science cases, there are the detection of biosignatures from exoplanet atmospheres, finding the fingerprints of the first generation of stars, tests on the stability of Nature's fundamental couplings, and the direct detection of the cosmic acceleration. The ANDES project is carried forward by a large international consortium, composed of 35 Institutes from 13 countries, forming a team of almost 300 scientists and engineers which include the majority of the scientific and technical expertise in the field that can be found in ESO member states., Comment: SPIE astronomical telescope and instrumentation 2024, in press

Published
2024

48. Antifungal activity of guanidine compounds

Author

Eguiluz, Alexandra Daniela Barrios, Orlandi, Caroline Barcelos Costa, Do Espírito Santo, Rafael Días, Zampieri, Eduardo Henrique, dos Anjos, Luana Ribeiro, Giannini, Maria José Soares Mendes, Fusco-Almeida, Ana Marisa, Valentini, Sandro Roberto, Zanelli, Cleslei Fernando, de Souza-Moreira, Tatiana Maria, and González, Eduardo René Pérez

Published
2025
Full Text
View/download PDF

49. Intraoperative neuromonitoring in destabilized spine: development of an intraoperative checklist to optimize response. A Delphi consensus report

Author

Tedesco, Giuseppe, Fusco, Eulalia Iolanda, Tedesco, Elena, Ghermandi, Riccardo, Cappelletto, Barbara, Romoli, Stefano, Fontanella, Marco, Garbossa, Diego, Rispoli, Rossella, Griffoni, Cristiana, Grippo, Antonello, Costa, Paolo, Falzetti, Luigi, Tosini, Giovanni, Barbanti Brodano, Giovanni, Vommaro, Francesco, Ricci, Alessandro, and Gasbarrini, Alessandro

Published
2025
Full Text
View/download PDF

50. An AI-assisted morphoproteomic approach is a supportive tool in esophagitis-related precision medicine

Author

Mattern, Sven, Hollfoth, Vanessa, Bag, Eyyub, Ali, Arslan, Riemenschneider, Philip, Jarboui, Mohamed A, Boldt, Karsten, Sulyok, Mihaly, Dickemann, Anabel, Luibrand, Julia, Fusco, Stefano, Franz-Wachtel, Mirita, Singer, Kerstin, Goeppert, Benjamin, Schilling, Oliver, Malek, Nisar, Fend, Falko, Macek, Boris, Ueffing, Marius, and Singer, Stephan

Published
2025
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results