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1. Immunogenicity and reactogenicity of modified vaccinia Ankara pre-exposure vaccination against mpox according to previous smallpox vaccine exposure and HIV infection: prospective cohort study

Author

Anzalone, Enza, Camici, Marta, Cannone, Fabio, Caputi, Priscilla, Cimaglia, Claudia, Corso, Rita, Cristofanelli, Flavia, Cruciani, Stefania, De Marco, Nicola, De Ponte, Chiara, Del Duca, Giulia, Faccendini, Paolo, Faraglia, Francesca, Faticoni, Augusto, Fusto, Marisa, Gebremeskel, Saba, Giancola, Maria Letizia, Giannico, Giuseppina, Gili, Simona, Iannella, Maria Rosaria, Junea, Angela, Lamonaca, Alessandra, Marani, Alessandra, Masone, Erminia, Mastrorosa, Ilaria, Mazzotta, Stefania, Nappo, Alessandra, Natalini, Giorgia, Parisi, Alfredo, Passacantilli, Sara, Paulicelli, Jessica, Plazzi, Maria Maddalena, Possi, Adriano, Preziosi, Gianni, Rosati, Silvia, Rubino, Marika, Scanzano, Pietro, Scorzolini, Laura, Tomassi, Virginia, Vescovo, Maurizio, Vita, Serena, Caterini, Luciano, Coppola, Luigi, Kontogiannis, Dimitra, D'Ettorre, Gabriella, Ridolfi, Marco, Di Giambenedetto, Simona, Farinacci, Damiano, Latini, Alessandra, Marchili, Mauro, Marocco, Raffaella, Mazzotta, Valentina, Lepri, Alessandro Cozzi, Matusali, Giulia, Cimini, Eleonora, Piselli, Pierluca, Aguglia, Camilla, Lanini, Simone, Colavita, Francesca, Notari, Stefania, Oliva, Alessandra, Meschi, Silvia, Casetti, Rita, Mondillo, Vanessa, Vergori, Alessandra, Bettini, Aurora, Grassi, Germana, Pinnetti, Carmela, Lapa, Daniele, Tartaglia, Eleonora, Gallì, Paola, Mondi, Annalisa, Montagnari, Giulia, Gagliardini, Roberta, Nicastri, Emanuele, Lichtner, Miriam, Sarmati, Loredana, Tamburrini, Enrica, Mastroianni, Claudio, Stingone, Christof, Siddu, Andrea, Barca, Alessandra, Fontana, Carla, Agrati, Chiara, Girardi, Enrico, Vaia, Francesco, Maggi, Fabrizio, and Antinori, Andrea

Published
2024
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2. Sarilumab plus standard of care vs standard of care for the treatment of severe COVID-19: a phase 3, randomized, open-labeled, multi-center study (ESCAPE study)

Author

Agrati, Chiara, Andreoni, Massimo, Antinori, Andrea, Bai, Francesca, Beccacece, Alessia, Barreca, Filippo, Bertuccio, Maria Paola, Bini, Teresa, Boumis, Evangelo, Camici, Marta, Cauda, Roberto, Cerva, Carlotta, Cicalini, Stefania, Cingolani, Antonella, D'Arminio Monforte, Antonella, D'Urso, Angela, De Masi, Margherita, De Zottis, Federico, Del Borgo, Cosmo, Di Gennaro, Francesco, Emiliozzi, Arianna, Fantoni, Massimo, Fondaco, Laura, Fusto, Marisa, Gagliardini, Roberta, Giovannenze, Francesca, Grilli, Elisabetta, Iannetta, Marco, Iodice, Daniele, Lichtner, Miriam, Lorenzini, Patrizia, Maffongelli, Gaetano, Masone, Erminia, Massa, Barbara, Mastrorosa, Ilaria, Mazzotta, Valentina, Mencarini, Paola, Milozzi, Eugenia, Mondi, Annalisa, Mosti, Silvia, Murri, Rita, Negri, Marcantonio, Nicastri, Emanuele, Oliva, Gian Piero, Onnelli, Giovanna, Ottou, Sandrine, Pace, Pier Giorgio, Palmieri, Fabrizio, Paulicelli, Jessica, Pinnetti, Carmela, Plazzi, Maria Maddalena, Sarmati, Loredana, Segala, Francesco Vladimiro, Sorace, Chiara, Taddei, Eleonora, Vergori, Alessandra, Vitale, Pietro, Lamonica, Silvia, Girardi, Enrico, and Vaia, Francesco

Published
2023
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3. Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation

Author

Ciccosanti, Fabiola, Antonioli, Manuela, Sacchi, Alessandra, Notari, Stefania, Farina, Anna, Beccacece, Alessia, Fusto, Marisa, Vergori, Alessandra, D’Offizi, Gianpiero, Taglietti, Fabrizio, Antinori, Andrea, Nicastri, Emanuele, Marchioni, Luisa, Palmieri, Fabrizio, Ippolito, Giuseppe, Piacentini, Mauro, Agrati, Chiara, and Fimia, Gian Maria

Published
2022
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4. Poor durability of the neutralizing response against XBB sublineages after a bivalent mRNA COVID‐19 booster dose in persons with HIV.

Author

Matusali, Giulia, Vergori, Alessandra, Cimini, Eleonora, Mariotti, Davide, Mazzotta, Valentina, Lepri, Alessandro Cozzi, Colavita, Francesca, Gagliardini, Roberta, Notari, Stefania, Meschi, Silvia, Fusto, Marisa, Tartaglia, Eleonora, Girardi, Enrico, Maggi, Fabrizio, and Antinori, Andrea

Subjects
BOOSTER vaccines, SARS-CoV-2 Omicron variant, COVID-19, VACCINATION status, MESSENGER RNA
Abstract

We estimated the dynamics of the neutralizing response against XBB sublineages and T cell response in persons with HIV (PWH) with previous AIDS and/or CD4 < 200/mm3 receiving the bivalent original strain/BA.4‐5 booster dose in fall 2022. Samples were collected before the shot (Day 0), 15 days, 3, and 6 months after. PWH were stratified by immunization status: hybrid immunity (HI; vaccination plus COVID‐19) versus nonhybrid immunity (nHI; vaccination only). Fifteen days after the booster, 16% and 30% of PWH were nonresponders in terms of anti‐XBB.1.16 or anti‐EG.5.1 nAbs, respectively. Three months after, a significant waning of anti‐XBB.1.16, EG.5.1 and ‐XBB.1 nAbs was observed both in HI and nHI but nAbs in HI were higher than in nHI. Six months after both HI and nHI individuals displayed low mean levels of anti‐XBB.1.16 and EG.5.1 nAbs. Regarding T cell response, IFN‐γ values were stable over time and similar in HI and nHI. Our data showed that in PWH, during the prevalent circulation of the XBB.1.16, EG.5.1, and other XBB sublineages, a mRNA bivalent vaccine might not confer broad protection against them. With a view to the 2023/2024 vaccination campaign, the use of the monovalent XBB.1.5 mRNA vaccine should be urgently warranted in PWH to provide adequate protection. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Long Term Assessment of Anti-SARS-CoV-2 Immunogenicity after mRNA Vaccine in Persons Living with HIV

Author

Vergori, Alessandra, primary, Cozzi-Lepri, Alessandro, additional, Matusali, Giulia, additional, Cicalini, Stefania, additional, Bordoni, Veronica, additional, Meschi, Silvia, additional, Mazzotta, Valentina, additional, Colavita, Francesca, additional, Fusto, Marisa, additional, Cimini, Eleonora, additional, Notari, Stefania, additional, D’Aquila, Veronica, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Gagliardini, Roberta, additional, Mariotti, Davide, additional, Giannico, Giuseppina, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, Agrati, Chiara, additional, Maggi, Fabrizio, additional, and Antinori, Andrea, additional

Published
2023
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6. Long Term Assessment of Anti-SARS-CoV-2 Immunogenicity after mRNA Vaccine in PLWH

Author

Vergori, Alessandra, primary, Cozzi-Lepri, Alessandro, additional, Matusali, Giulia, additional, Cicalini, Stefania, additional, Bordoni, Veronica, additional, Meschi, Silvia, additional, Mazzotta, Valentina, additional, Colavita, Francesca, additional, Fusto, Marisa, additional, Cimini, Eleonora, additional, Notari, Stefania, additional, D'Aquila, Veronica, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Gagliardini, Roberta, additional, Mariotti, Davide, additional, Giannico, Giuseppina, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, Agrati, Chiara, additional, Maggi, Fabrizio, additional, and Antinori, Andrea, additional

Published
2023
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7. Neutralizing activity and T-cell response after bivalent fifth dose of messenger RNA vaccine in people living with HIV

Author

Vergori, Alessandra, primary, Matusali, Giulia, additional, Lepri, Alessandro Cozzi, additional, Cimini, Eleonora, additional, Fusto, Marisa, additional, Colavita, Francesca, additional, Gagliardini, Roberta, additional, Notari, Stefania, additional, Mazzotta, Valentina, additional, Mariotti, Davide, additional, Cicalini, Stefania, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, Maggi, Fabrizio, additional, and Antinori, Andrea, additional

Published
2023
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8. Sarilumab plus standard of care vs standard of care for the treatment of severe COVID-19: a phase 3, randomized, open-labeled, multi-center study (ESCAPE study)

Author

Mastrorosa, Ilaria, primary, Gagliardini, Roberta, additional, Segala, Francesco Vladimiro, additional, Mondi, Annalisa, additional, Lorenzini, Patrizia, additional, Cerva, Carlotta, additional, Taddei, Eleonora, additional, Bai, Francesca, additional, Vergori, Alessandra, additional, Negri, Marcantonio, additional, Pinnetti, Carmela, additional, Cicalini, Stefania, additional, Murri, Rita, additional, Mazzotta, Valentina, additional, Camici, Marta, additional, Mosti, Silvia, additional, Bini, Teresa, additional, Maffongelli, Gaetano, additional, Beccacece, Alessia, additional, Milozzi, Eugenia, additional, Iannetta, Marco, additional, Lamonica, Silvia, additional, Fusto, Marisa, additional, Plazzi, Maria Maddalena, additional, Ottou, Sandrine, additional, Lichtner, Miriam, additional, Fantoni, Massimo, additional, Andreoni, Massimo, additional, Sarmati, Loredana, additional, Cauda, Roberto, additional, Girardi, Enrico, additional, Nicastri, Emanuele, additional, D'Arminio Monforte, Antonella, additional, Palmieri, Fabrizio, additional, Cingolani, Antonella, additional, Vaia, Francesco, additional, Antinori, Andrea, additional, Agrati, Chiara, additional, Barreca, Filippo, additional, Bertuccio, Maria Paola, additional, Boumis, Evangelo, additional, D'Urso, Angela, additional, De Masi, Margherita, additional, De Zottis, Federico, additional, Del Borgo, Cosmo, additional, Di Gennaro, Francesco, additional, Emiliozzi, Arianna, additional, Fondaco, Laura, additional, Giovannenze, Francesca, additional, Grilli, Elisabetta, additional, Iodice, Daniele, additional, Masone, Erminia, additional, Massa, Barbara, additional, Mastrorosa, Ilaria, additional, Mencarini, Paola, additional, Oliva, Gian Piero, additional, Onnelli, Giovanna, additional, Pace, Pier Giorgio, additional, Paulicelli, Jessica, additional, Sorace, Chiara, additional, and Vitale, Pietro, additional

Published
2023
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9. Declining Prevalence of Human Immunodeficiency Virus (HIV)–Associated Neurocognitive Disorders in Recent Years and Associated Factors in a Large Cohort of Antiretroviral Therapy–Treated Individuals With HIV

Author

Mastrorosa, Ilaria, primary, Pinnetti, Carmela, additional, Brita, Anna Clelia, additional, Mondi, Annalisa, additional, Lorenzini, Patrizia, additional, Del Duca, Giulia, additional, Vergori, Alessandra, additional, Mazzotta, Valentina, additional, Gagliardini, Roberta, additional, Camici, Marta, additional, De Zottis, Federico, additional, Fusto, Marisa, additional, Plazzi, Maria Maddalena, additional, Grilli, Elisabetta, additional, Bellagamba, Rita, additional, Cicalini, Stefania, additional, and Antinori, Andrea, additional

Published
2022
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10. SARS-CoV-2 Omicron Variant Neutralization after Third Dose Vaccination in PLWH

Author

Vergori, Alessandra, primary, Cozzi-Lepri, Alessandro, additional, Matusali, Giulia, additional, Colavita, Francesca, additional, Cicalini, Stefania, additional, Gallì, Paola, additional, Garbuglia, Anna Rosa, additional, Fusto, Marisa, additional, Puro, Vincenzo, additional, Maggi, Fabrizio, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, and Antinori, Andrea, additional

Published
2022
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11. Additional file 1 of Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation

Author

Ciccosanti, Fabiola, Antonioli, Manuela, Sacchi, Alessandra, Notari, Stefania, Farina, Anna, Beccacece, Alessia, Fusto, Marisa, Vergori, Alessandra, D’Offizi, Gianpiero, Taglietti, Fabrizio, Antinori, Andrea, Nicastri, Emanuele, Marchioni, Luisa, Palmieri, Fabrizio, Ippolito, Giuseppe, Piacentini, Mauro, Agrati, Chiara, and Fimia, Gian Maria

Abstract

Additional file 1: Tables S1: Demographics, clinical baseline characteristics, therapy and cause of death of COVID-19 patients.

Published
2022
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12. Declining Prevalence of Human Immunodeficiency Virus (HIV)–Associated Neurocognitive Disorders in Recent Years and Associated Factors in a Large Cohort of Antiretroviral Therapy–Treated Individuals With HIV.

Author

Mastrorosa, Ilaria, Pinnetti, Carmela, Brita, Anna Clelia, Mondi, Annalisa, Lorenzini, Patrizia, Duca, Giulia Del, Vergori, Alessandra, Mazzotta, Valentina, Gagliardini, Roberta, Camici, Marta, Zottis, Federico De, Fusto, Marisa, Plazzi, Maria Maddalena, Grilli, Elisabetta, Bellagamba, Rita, Cicalini, Stefania, and Antinori, Andrea

Subjects
HIV infection epidemiology, HIV infection complications, MENTAL illness drug therapy, HIV infections, COGNITION disorders, AIDS dementia complex, HIV integrase inhibitors, CROSS-sectional method, MULTIVARIATE analysis, MULTIPLE regression analysis, AGE distribution, ANTIRETROVIRAL agents, TREATMENT effectiveness, CHI-squared test, DISEASE prevalence, NON-nucleoside reverse transcriptase inhibitors, RESEARCH funding, EDUCATIONAL attainment, EVALUATION
Abstract

Background HIV-associated neurocognitive disorders (HAND) have been suggested as persistent even with effective antiretroviral therapy (ART). Aims were to evaluate HAND prevalence and associated factors, in a large cohort of people-with-HIV (PWH). Methods ART-treated PWH, underwent a neuropsychological examination through a battery of 12 tests exploring 5 different domains, between 2009 and 2020, were included in this cross-sectional analysis. HAND were classified according to Frascati's criteria. Participants were defined as complaining or not-complaining if a cognitive complaint was reported or not. Chi-square for trend and multivariable logistic regression were fitted. Results Overall, 1424 PWH were enrolled during four three-years periods. HAND prevalence was 24%; among complainers (572/1424), it was 38%, higher than among not-complainers (15%). Over the study period, a decreasing HAND prevalence was found in the entire population (P < 0.001) and in complaining (P < 0.001); in not-complaining it remained stable (P = 0.182). Factors associated with HAND were older age, lower educational level, lower current CD4+ T-cell count and HCV co-infection. Compared to nonnucleoside reverse transcriptase inhibitors, receiving dual and integrase strand transfer inhibitor (INSTI)-based therapies was associated with a decreased risk of HAND, as well as being tested in more recent years. Conclusions In this large cohort of ART-treated PWH, mostly virologically suppressed, a remarkable decreasing HAND prevalence was observed. Besides HIV- and patient-related factors, the reduced risk of HAND found with dual and INSTI-based regimens along with a more recent ART initiation, could suggest a potential role of new treatment strategies in this decline, due to their greater virologic efficacy and better tolerability. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Characteristics and Outcomes of COVID-19-Related Hospitalization among PLWH

Author

Gagliardini, Roberta, primary, Vergori, Alessandra, additional, Lorenzini, Patrizia, additional, Cicalini, Stefania, additional, Pinnetti, Carmela, additional, Mazzotta, Valentina, additional, Mondi, Annalisa, additional, Mastrorosa, Ilaria, additional, Camici, Marta, additional, Lanini, Simone, additional, Fusto, Marisa, additional, Paulicelli, Jessica, additional, Plazzi, Maria Maddalena, additional, Marchioni, Luisa, additional, Agrati, Chiara, additional, Garbuglia, Anna Rosa, additional, Piselli, Pierluca, additional, Nicastri, Emanuele, additional, Taglietti, Fabrizio, additional, Palmieri, Fabrizio, additional, D’Offizi, Gianpiero, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, and Antinori, Andrea, additional

Published
2022
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14. Sarilumab Plus Standard of Care Versus Standard of Care for the Treatment of Severe COVID-19: A Phase 3, Randomized, Open-Labeled, Multi-Center Study (ESCAPE Study)

Author

Mastrorosa, Ilaria, primary, Gagliardini, Roberta, additional, Segala, Francesco, additional, Mondi, Annalisa, additional, Lorenzini, Patrizia, additional, Cerva, Carlotta, additional, Taddei, Eleonora, additional, Bai, Francesca, additional, Vergori, Alessandra, additional, Marcantonio, Negri, additional, Pinnetti, Carmela, additional, Cicalini, Stefania, additional, Murri, Rita, additional, Mazzotta, Valentina, additional, Camici, Marta, additional, Mosti, Silvia, additional, Bini, Teresa, additional, Maffongelli, Gaetano, additional, Beccacece, Alessia, additional, Milozzi, Eugenia, additional, Iannetta, Marco, additional, Lamonica, Silvia, additional, Fusto, Marisa, additional, Plazzi, Maria Maddalena, additional, Ottou, Sandrine, additional, Lichtner, Miriam, additional, Fantoni, Massimo, additional, Andreoni, Massimo, additional, Sarmati, Loredana, additional, Cauda, Roberto, additional, Girardi, Enrico, additional, Nicastri, Emanuele, additional, D'Arminio Monforte, Antonella, additional, Palmieri, Fabrizio, additional, Cingolani, Antonella, additional, Vaia, Francesco, additional, Antinori, Andrea, additional, and Group, ESCAPE Study, additional

Published
2022
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15. Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against SARS-CoV-2 in People Living with HIV (PLWH) Receiving Antiretroviral Therapy (ART) According with Current CD4 T-Lymphocyte Count

Author

Antinori, Andrea, primary, Cicalini, Stefania, additional, Meschi, Silvia, additional, Bordoni, Veronica, additional, Lorenzini, Patrizia, additional, Vergori, Alessandra, additional, Lanini, Simone, additional, De Pascale, Lidya, additional, Matusali, Giulia, additional, Mariotti, Davide, additional, Lepri, Alessandro Cozzi, additional, Gallì, Paola, additional, Pinnetti, Carmela, additional, Gagliardini, Roberta, additional, Mazzotta, Valentina, additional, Mastrorosa, Ilaria, additional, Grisetti, Susanna, additional, Colavita, Francesca, additional, Cimini, Eleonora, additional, Grilli, Elisabetta, additional, Bellagamba, Rita, additional, Lapa, Daniele, additional, Sacchi, Alessandra, additional, Marani, Alessandra, additional, Cerini, Carlo, additional, Candela, Caterina, additional, Fusto, Marisa, additional, Puro, Vincenzo, additional, Castilletti, Concetta, additional, Agrati, Chiara, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, and Group, HIV-VAC Study, additional

Published
2021
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16. Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia

Author

Mori, Mattia, primary, Tottone, Luca, additional, Quaglio, Deborah, additional, Zhdanovskaya, Nadezda, additional, Ingallina, Cinzia, additional, Fusto, Marisa, additional, Ghirga, Francesca, additional, Peruzzi, Giovanna, additional, Crestoni, Maria Elisa, additional, Simeoni, Fabrizio, additional, Giulimondi, Francesca, additional, Talora, Claudio, additional, Botta, Bruno, additional, Screpanti, Isabella, additional, and Palermo, Rocco, additional

Published
2017
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18. Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation

Author

Ciccosanti, Fabiola, Antonioli, Manuela, Sacchi, Alessandra, Notari, Stefania, Farina, Anna, Beccacece, Alessia, Fusto, Marisa, Vergori, Alessandra, D'Offizi, Gianpiero, Taglietti, Fabrizio, Antinori, Andrea, Nicastri, Emanuele, Marchioni, Luisa, Palmieri, Fabrizio, Ippolito, Giuseppe, Piacentini, Mauro, Agrati, Chiara, Fimia, Gian Maria, Ciccosanti, Fabiola, Antonioli, Manuela, Sacchi, Alessandra, Notari, Stefania, Farina, Anna, Beccacece, Alessia, Fusto, Marisa, Vergori, Alessandra, D'Offizi, Gianpiero, Taglietti, Fabrizio, Antinori, Andrea, Nicastri, Emanuele, Marchioni, Luisa, Palmieri, Fabrizio, Ippolito, Giuseppe, Piacentini, Mauro, Agrati, Chiara, and Fimia, Gian Maria

Subjects
Platelets, Proteomics, Settore BIO/06, Neutrophils, Neutrophil, Platelet, Clinical Biochemistry, Complement, Proteomic, General Medicine, Plasma, Molecular Medicine, SARS CoV 2, Molecular Biology
Abstract

Most patients infected with SARS-CoV-2 display mild symptoms with good prognosis, while 20% of patients suffer from severe viral pneumonia and up to 5% may require intensive care unit (ICU) admission due to severe acute respiratory syndrome, which could be accompanied by multiorgan failure.Plasma proteomics provide valuable and unbiased information about disease progression and therapeutic candidates. Recent proteomic studies have identified molecular changes in plasma of COVID-19 patients that implied significant dysregulation of several aspects of the inflammatory response accompanied by a general metabolic suppression. However, which of these plasma alterations are associated with disease severity remains only partly characterized.A known limitation of proteomic studies of plasma samples is the large difference in the macromolecule abundance, with concentration spanning at least 10 orders of magnitude. To improve the coverage of plasma contents, we performed a deep proteomic analysis of plasma from 10 COVID-19 patients with severe/fatal pneumonia compared to 10 COVID-19 patients with pneumonia who did not require ICU admission (non-ICU). To this aim, plasma samples were first depleted of the most abundant proteins, trypsin digested and peptides subjected to a high pH reversed-phase peptide fractionation before LC–MS analysis.These results highlighted an increase of proteins involved in neutrophil and platelet activity and acute phase response, which is significantly higher in severe/fatal COVID-19 patients when compared to non-ICU ones. Importantly, these changes are associated with a selective induction of complement cascade factors in severe/fatal COVID-19 patients. Data are available via ProteomeXchange with identifier PXD036491. Among these alterations, we confirmed by ELISA that higher levels of the neutrophil granule proteins DEFA3 and LCN2 are present in COVID-19 patients requiring ICU admission when compared to non-ICU and healthy donors.Altogether, our study provided an in-depth view of plasma proteome changes that occur in COVID-19 patients in relation to disease severity, which can be helpful to identify therapeutic strategies to improve the disease outcome.

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19. Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in People Living With Human Immunodeficiency Virus Receiving Antiretroviral Therapy Based on Current CD4 T-Lymphocyte Count

Author

Andrea, Antinori, Stefania, Cicalini, Silvia, Meschi, Veronica, Bordoni, Patrizia, Lorenzini, Alessandra, Vergori, Simone, Lanini, Lidya, De Pascale, Giulia, Matusali, Davide, Mariotti, Alessandro, Cozzi Lepri, Paola, Gallì, Carmela, Pinnetti, Roberta, Gagliardini, Valentina, Mazzotta, Ilaria, Mastrorosa, Susanna, Grisetti, Francesca, Colavita, Eleonora, Cimini, Elisabetta, Grilli, Rita, Bellagamba, Daniele, Lapa, Alessandra, Sacchi, Alessandra, Marani, Carlo, Cerini, Caterina, Candela, Marisa, Fusto, Vincenzo, Puro, Concetta, Castilletti, Chiara, Agrati, Enrico, Girardi, Francesco, Vaia, Antinori, Andrea, Cicalini, Stefania, Meschi, Silvia, Bordoni, Veronica, Lorenzini, Patrizia, Vergori, Alessandra, Lanini, Simone, De Pascale, Lidya, Matusali, Giulia, Mariotti, Davide, Cozzi Lepri, Alessandro, Gallì, Paola, Pinnetti, Carmela, Gagliardini, Roberta, Mazzotta, Valentina, Mastrorosa, Ilaria, Grisetti, Susanna, Colavita, Francesca, Cimini, Eleonora, Grilli, Elisabetta, Bellagamba, Rita, Lapa, Daniele, Sacchi, Alessandra, Marani, Alessandra, Cerini, Carlo, Candela, Caterina, Fusto, Marisa, Puro, Vincenzo, Castilletti, Concetta, Agrati, Chiara, Girardi, Enrico, and Vaia, Francesco

Subjects
Microbiology (medical), CD4-Positive T-Lymphocytes, COVID-19 Vaccines, CoV, COVID-19 Vaccine, HIV Infections, immunogenicity, Antibodies, Viral, anti, Humans, HIV Infection, Lymphocyte Count, Prospective Studies, RNA, Messenger, BNT162 Vaccine, SARS, Immunity, Cellular, 2 vaccine, SARS-CoV-2, Vaccination, COVID-19, HIV, Viral Vaccines, AIDS, Prospective Studie, Infectious Diseases, CD4-Positive T-Lymphocyte, Immunoglobulin G, Human
Abstract

Background Data on SARS-CoV-2 vaccine immunogenicity in PLWH are currently limited. Aim of the study was to investigate immunogenicity according to current CD4 T-cell count Methods PLWH on ART attending a SARS-CoV-2 vaccination program, were included in a prospective immunogenicity evaluation after receiving BNT162b2 or mRNA-1273. Participants were stratified by current CD4 T-cell count (poor CD4 recovery, PCDR: 500/mm3). RBD-binding IgG, SARS-CoV-2 neutralizing antibodies (nAbs) and IFN-γ release were measured. As control group, HIV-negative healthcare workers (HCWs) were used Findings Among 166 PLWH, after 1 month from the booster dose, detectable RBD-binding IgG were elicited in 86.7% of PCDR, 100% of ICDR, 98.7% of HCDR, and a neutralizing titre ≥1:10 elicited in 70.0%, 88.2%, and 93.1%, respectively. Compared to HCDR, all immune response parameters were significantly lower in PCDR. After adjusting for confounders, current CD4 T-cell Conclusion Humoral and cell-mediated immune response against SARS-CoV-2 were elicited in most of PLWH, albeit significantly poorer in those with CD4 T-cell 500 cell/mm3 and HIV-negative controls. A lower RBD-binding antibody response than HCWs was also observed in PLWH with CD4 T-cell 200–500/mm3, whereas immune response elicited in PLWH with a CD4 T-cell >500/mm3 was comparable to HIV-negative population

Published
2021

20. Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in People Living With Human Immunodeficiency Virus Receiving Antiretroviral Therapy Based on Current CD4 T-Lymphocyte Count.

Author

Antinori A, Cicalini S, Meschi S, Bordoni V, Lorenzini P, Vergori A, Lanini S, De Pascale L, Matusali G, Mariotti D, Cozzi Lepri A, Gallì P, Pinnetti C, Gagliardini R, Mazzotta V, Mastrorosa I, Grisetti S, Colavita F, Cimini E, Grilli E, Bellagamba R, Lapa D, Sacchi A, Marani A, Cerini C, Candela C, Fusto M, Puro V, Castilletti C, Agrati C, Girardi E, and Vaia F

Subjects
Antibodies, Viral, BNT162 Vaccine, CD4-Positive T-Lymphocytes, COVID-19 Vaccines, HIV, Humans, Immunity, Cellular, Immunoglobulin G, Lymphocyte Count, Prospective Studies, RNA, Messenger, SARS-CoV-2, Vaccination, COVID-19 prevention & control, HIV Infections drug therapy, Viral Vaccines
Abstract

Background: Data on SARS-CoV-2 vaccine immunogenicity in PLWH are currently limited. Aim of the study was to investigate immunogenicity according to current CD4 T-cell count., Methods: PLWH on ART attending a SARS-CoV-2 vaccination program, were included in a prospective immunogenicity evaluation after receiving BNT162b2 or mRNA-1273. Participants were stratified by current CD4 T-cell count (poor CD4 recovery, PCDR: <200/mm3; intermediate CD4 recovery, ICDR: 200-500/mm3; high CD4 recovery, HCDR: >500/mm3). RBD-binding IgG, SARS-CoV-2 neutralizing antibodies (nAbs) and IFN-γ release were measured. As control group, HIV-negative healthcare workers (HCWs) were used., Findings: Among 166 PLWH, after 1 month from the booster dose, detectable RBD-binding IgG were elicited in 86.7% of PCDR, 100% of ICDR, 98.7% of HCDR, and a neutralizing titre ≥1:10 elicited in 70.0%, 88.2%, and 93.1%, respectively. Compared to HCDR, all immune response parameters were significantly lower in PCDR. After adjusting for confounders, current CD4 T-cell <200/mm3 significantly predicted a poor magnitude of anti-RDB, nAbs and IFN-γ response. As compared with HCWs, PCDR elicited a consistently reduced immunogenicity for all parameters, ICDR only a reduced RBD-binding antibody response, whereas HCDR elicited a comparable immune response for all parameters., Conclusion: Humoral and cell-mediated immune response against SARS-CoV-2 were elicited in most of PLWH, albeit significantly poorer in those with CD4 T-cell <200/mm3 versus those with >500 cell/mm3 and HIV-negative controls. A lower RBD-binding antibody response than HCWs was also observed in PLWH with CD4 T-cell 200-500/mm3, whereas immune response elicited in PLWH with a CD4 T-cell >500/mm3 was comparable to HIV-negative population., (© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America.)

Published
2022
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