Search

We developed a CANDLES-III system to study the neutrino-less double beta (0$\nu\beta\beta$) decay of $^{48}$Ca. The proposed system employs 96 CaF$_{2}$ scintillation crystals (305 kg) with natural Ca ($^{\rm nat.}$Ca) isotope which corresponds 350\,g of $^{48}$Ca. External backgrounds were rejected using a 4$\pi$ active shield of a liquid scintillator surrounding the CaF$_2$ crystals. The internal backgrounds caused by the radioactive impurities within the CaF$_2$ crystals can be reduced effectively through analysis of the signal pulse shape. We analyzed the data obtained in the Kamioka underground for a live-time of 130.4\,days to evaluate the feasibility of the low background measurement with the CANDLES-III detector. Using Monte Carlo simulations, we estimated the background rate from the radioactive impurities in the CaF$_{2}$ crystals and the rate of high energy $\gamma$-rays caused by the (n, $\gamma$) reactions induced by environmental neutrons. The expected background rate was in a good agreement with the measured rate, i.e., approximately 10$^{-3}$ events/keV/yr/(kg of $^{\rm nat.}$Ca), in the 0$\nu\beta\beta$ window. In conclusion, the background candidates were estimated properly by comparing the measured energy spectrum with the background simulations. With this measurement method, we performed the first search for 0$\nu\beta\beta$ decay in a low background condition using a detector with a Ca isotope, in which the Ca present was not enriched, in a scale of hundreds of kg. The $^{48}$Ca isotope has a high potential for use in 0$\nu\beta\beta$ decay search, and is expected to be useful for the development of a next-generation detector for highly sensitive measurements.

In remote sensing of planetary bodies, the development of analysis techniques that lead to quantitative interpretations of datasets has relatively been deficient compared to the wealth of acquired data, especially in the case of regoliths with particle sizes on the order of the probing wavelength. Radiative transfer theory has often been applied to the study of densely packed particulate media like planetary regoliths, but with difficulty; here we continue to improve theoretical modeling of spectra of densely packed particulate media. We use the superposition T-matrix method to compute the scattering properties of an elementary volume entering the radiative transfer equation by modeling it as a cluster of particles and thereby capture the near-field effects important for dense packing. Then, these scattering parameters are modified with the static structure factor correction to suppress the irrelevant far-field diffraction peak rendered by the T-matrix procedure. Using the corrected single­ scattering parameters, reflectance (and emissivity) is computed via the invariant-imbedding solution to the scalar radiative transfer equation. We modeled the emissivity spectrum of the 3.3 μm particle size fraction of enstatite, representing a common regolith component, in the mid-infrared (~5 – 50 μm). The use of the static structure factor correction coupled with the superposition T-matrix method produced better agreement with the corresponding laboratory spectrum than the sole use of the T-matrix method, particularly for volume scattering wavelengths (transparency features). This work demonstrates the importance of proper treatment of the packing effects when modeling semi-infinite densely packed particulate media using finite, cluster-based light scattering models.

Mid-infrared spectroscopy is a useful tool for remotely sensing the composition of Earth and other planets. Quantitative mineralogical investigations are possible using remotely sensed data; however, the difficulty in modeling complex interactions of light with particles that are on the order of the wavelength limits the usefulness of the remote sensing data. As part of an effort to develop a more effective treatment of light scattering in planetary regolith, we explore the ability of T-matrix and radiative transfer (RT) hybrid models to produce emissivity spectra that are consistent with laboratory measurements. Parameters obtained from T-matrix calculations are used in three different RT models to construct emissivity spectra of enstatite particles of different sizes. Compared to the widely used Mie/RT hybrid models, the T-matrix/RT hybrid models produce more consistent emissivity spectra for the finest particle size fraction (3.3 μm). Overall, T-matrix hybrid models produce improved emissivity spectra, but larger particle sizes are still difficult to model. The improvement observed in T-matrix/RT hybrid models is a result of the inclusion of multiple scattering in closely packed media, and it demonstrates the importance of the implementation of physically realistic factors in developing a more effective light scattering model for planetary regolith. Further development and implementation of this and similar hybrid models will result in an improvement in quantitative assessments of planetary particulate surfaces from mid-infrared spectra.

During the 2014-2015 mutual events season, the Institut de Mécanique Céleste et de Calcul des Éphémérides (IMCCE), Paris, France, and the Sternberg Astronomical Institute (SAI), Moscow, Russia, led an international observation campaign to record ground-based photometric observations of Galilean moon mutual occultations and eclipses.We focused on processing the complete photometric observations data base to compute new accurate astrometric positions. We used our method to derive astrometric positions from the light curves of the events. We developed an accurate photometric model of mutual occultations and eclipses, while correcting for the satellite albedos, Hapke's light scattering law, the phase effect, and the limb darkening. We processed 609 light curves, and we compared the observed positions of the satellites with the theoretical positions from IMCCE NOE-5-2010-GAL satellite ephemerides and INPOP13c planetary ephemeris. The standard deviation after fitting the light curve in equatorial positions is ±24 mas, or 75 km at Jupiter. The rms (O-C) in equatorial positions is ±50 mas, or 150 km at Jupiter. © 2017 The Author(s).

A newly found fast radiative cooling process of C 6 - is studied by simulation based on statistical sharing of the internal energy by the vibrational modes both in the electronic ground and excited states. For comparison, a contrasting slow cooling of C6H− is simulated by the same procedure. The simulation demonstrates a distinct difference in the time evolution of energy distributions between C 6 - and C 6 H−, and well reproduces the observed fast cooling of C 6 - by recurrent electronic transitions and the slow cooling of C6H− by vibrational de-excitation.

CANDLES is the project to search for neutrino-less double beta decay ( 0νββ ) of 48 Ca. The observation of 0νββ will prove existence of a massive Majorana neutrino. For the 0νββ measurement, we need a low background condition because of a low decay rate of 0νββ . Now we installed the CANDLES III system at the Kamioka underground laboratory. The CANDLES III system realizes the low background condition by a characteristic structure and data analyses for background rejection. Here we report performances of the CANDLES III system.

Many countries with incidence of malaria, including those surrounding Maputo Bay, use dichloro-diphenyl-trichloroethane (DDT) to reduce mosquitoes. This study is the first to estimate the human health risk associated with consumption of marine fish from Maputo Bay contaminated with DDTs. The median for ∑DDTs was 3.8 ng/g ww (maximum 280.9 ng/g ww). The overall hazard ratio for samples was 1.5 at the 75th percentile concentration and 28.2 at the 95th percentile. These calculations show increased potential cancer risks due to contamination by DDTs, data which will help policy makers perform a risk–benefit analysis of DDT use in malaria control programs in the region.

We present a novel optical amplitude regenerator based on blue-chirp spectral slicing using a semiconductor optical amplifier (SOA). The combination of blue-chirp spectral slicing and gain competition in the SOA has a unique input/output (I/O) power-transfer function, which is controlled by the power of an input data signal injected into the SOA. The I/O power-transfer function provides selective amplitude-level regeneration of either the mark or space level of the input data signal. In this paper, we experimentally investigate the transfer function and the regeneration effect using a quantum-dot semiconductor optical amplifier. The results show that the regenerator has unique regeneration effect, specialized for either the mark or space level of a 10-Gbit/s on-off keying signal.

Distortion of laser-induced fluorescence profiles attributable to optical absorption and saturation broadening was corrected in combination with laser absorption spectroscopy in argon plasma flow. At high probe-laser intensity, saturated absorption profiles were measured to correct probe-laser absorption. At low laser intensity, nonsaturated absorption profiles were measured to correct fluorescence reabsorption. Saturation broadening at the measurement point was corrected using a ratio of saturated to non-saturated broadening. Observed LIF broadening and corresponding translational temperature without correction were, respectively,2.20±0.05 GHz and2510±100 K and corrected broadening and temperature were, respectively,1.96±0.07 GHz and1990±150 K. Although this correction is applicable only at the center of symmetry, the deduced temperature agreed well with that obtained by LAS with Abel inversion.

Limited evidence is available as to whether Kampo medicine modifies gastrointestinal function in humans. We investigated the effect of a Kampo medicine, Hange-koboku-to (Banxia-houpo-tang, HKT), on patients with functional dyspepsia (FD) and on healthy volunteers with regard to gastric motility. The gastric emptying rate (GER) in FD patients was significantly lower than in the healthy subjects. GER in FD patients and in healthy volunteers showed a significant increase after 2 weeks of medication with HKT. Furthermore, gastrointestinal symptoms improved significantly in the FD patients after the administration of HKT. These results suggest that HKT improves delayed gastric emptying and acts as a prokinetic agent.

(2004). Mechanical properties of friction stir welded 6061 aluminium alloys. Welding International: Vol. 18, No. 2, pp. 95-102.

Two types of the karyomorphs in the katydid Mecopoda elongata (L.) from Borneo (Malaysia) and Amami Is. (Japan) were found. The chromosomal comple- ment of M. elongata from Amami Is. and one karyomorph from Borneo (Kota Kinabalu - song 1) consists of 28 autosomes plus the X in the male (2n=29). In two long pairs, pair L1 is metacentric, whereas pair L2 is subacrocentric. Other autosomes are meta or submetacentric. The size and shape of the X chromosome is similar to the L1 pair. "Kota Kinabalu - song-2" karyomorph has the same chromosome num- ber as "KK song-1" and "Amami". However, in "KK song-2" the autosomes belong- ing to L2 pair are metacentric. The size of these chromosomes is approximately sim- ilar to the L1 pair and the X chromosome. The discrete chromosome differentiation in M. elongata suggest that this species consists of several biological species. In M. elongata from Borneo, the assumption of a belonging of two groups of the kary- omorphs to different species proves to be true also in differences in crepitating.

Soft tissue stretching has been proposed as one of the control factors in craniofacial morphogenesis. However, its mechanism remains unclear. The present study investigated electromyographic (EMG) activity and muscle fibre composition of cervical muscles following prolonged head extension in growing rats. Thirty-six male Wistar rats were divided into two experimental (E1, E2) and one control (C) group at 25 days of age. To induce head extension, the experimental rats were raised in cylindrical cages, which were positioned horizontally for group E1 and tilted upward at 45 degrees for group E2. At 55 days of age, EMG activity was recorded from the anterior digastricus (AD), sternohyoideus (SH), sternomastoideus (SM), longus capitis (LC), and biventer cervicis (BC) muscles in the rest position and passive head extension. EMG activity was analysed on its integrated values (IEMG), and composition of muscle fibres was evaluated by myosin ATPase reaction and fibre cross-sectional areas were calculated. Group E1 showed a higher percentage of type I fibres and lower IEMG during passive head extension in AD. In group E2 there was a higher percentage of type I fibres, a higher IEMG at rest, and a lower IEMG during passive head extension in BC. The experimental groups demonstrated altered proportions of type IIA and IIB fibres in SM and LC. They also showed higher percentages of subtype fibres and reduced cross-section areas of type II fibres in most of the muscles investigated. These findings suggest that head extension affects fibre transition, distribution, cross-section area, and recruitment pattern in cervical muscles.

We report conclusive evidence of an efficient cooling mechanism via the electronic radiative transitions of hot small molecular anions isolated in vacuum. We stored ${{\mathrm{C}}_{6}}^{\ensuremath{-}}$ and ${\mathrm{C}}_{6}{\mathrm{H}}^{\ensuremath{-}}$ in an ion storage ring and observed laser-induced electron detachment with delays up to several milliseconds. The terminal hydrogen atom caused a drastic change in the decay profiles. The decay of photoexcited ${\mathrm{C}}_{6}{\mathrm{H}}^{\ensuremath{-}}$ is slow and nonexponential, which can be explained by depletion cooling, whereas that for ${{\mathrm{C}}_{6}}^{\ensuremath{-}}$ occurs extremely fast, on a time scale below 0.1 ms and can only be explained by electronic radiative cooling via low-lying electronic excited states.

Clinical/occlusal scores and jaw-muscle EMGs were recorded in 24 TMD symptomatic (group S) and 20 normal (group N) subjects to evaluate the significance of EMG parameters and their clinical associations. Results indicated: (1) integrated EMG activity (IEMG) was larger at the rest position (RP) in anterior temporalis (Ta) but smaller at maximal voluntary clenching (MVC) in masseter (Ma) and Ta, and the ratios of IEMG at 70%MVC to the corresponding bite force (70%BF) were greater in group S; (2) mean power frequency (MPF) were almost the same in both groups but its shift was more rapid in group S; (3) silent period duration (SPD) was longer in group S; (4) asymmetry indices for SPD and silent period latency (SPL) were larger in group S; (5) muscle pain was associated negatively with IEMG at MVC and 70%BF but positively with IEMGs at RP and 70%MVC, and impaired jaw movements were associated negatively with the above EMG values; (6) muscle pain was positively associated with SPD in Ma, while joint pain and sound showed positive and negative associations with SPD, respectively; (7) associations between occlusion and EMG parameters were found more in group N. These findings verify: (1) jaw elevators in TMD may have hyper-tonic activities and a weak functional efficiency; (2) jaw muscles in TMD may become easily fatigued following a functional effort, and less relaxed following a muscle twitch; (3) the severity of pain could not be reflected in EMG activities, but impaired jaw movement may increase tonic activity and decrease functional effort; (4) TMD symptoms may alter the functional adaptation of jaw-muscle activities and occlusion.

Decreased masticatory demands due to liquid or soft diets cause a reduction in the growth of craniofacial bones and in the development of feeding musculature, but the effects on masticatory function and jaw/tongue muscle activities are unclear. The present study was undertaken to test the hypotheses that a liquid diet feeding after weaning affects the critical-period programming of mastication and the motor performances of jaw and tongue muscles. Thirty-six male Wistar rats were divided into two equals groups at weaning and fed either a solid (solid-diet group) or a liquid (liquid-diet group) diet until they reached 50 days of age. Electromyograms (EMG) of the masseter, medial pterygoid, temporalis, anterior digastric, styloglossus, and genioglossus were recorded while animals were naturally ingesting ordinary pellets, apple cubes, and a liquid diet. It was found that: (1) a more irregular chewing rhythm, a shorter chewing sequence, and a longer chewing cycle were found in the liquid-diet group, but there were no differences observed during lapping/licking between the two groups; (2) during the chewing cycles, the EMG onset of each muscle in relation to that of the masseter in the liquid-diet group was similar to that in the lapping/licking cycles in both groups; (3) the activities of jaw elevators (masseter, medial pterygoid, and temporalis) during the chewing cycles were significantly higher in the liquid-diet group; and (4) the increase in the EMG activities of jaw elevators during pellet chewing compared with apple cube chewing was significantly weaker in the liquid-diet group, whereas such an enhancement was found simultaneously in the styloglossus in the solid-diet group, and in the anterior digastric in the liquid-diet group. These findings verify that: (1) the motor output of jaw and tongue muscles may be altered in rats fed a liquid diet after being weaned; (2) the feeding of a liquid diet to rats after being weaned may obstruct the functional transition from suckling to mastication; and (3) jaw elevators that develop without motor learning of mastication are inefficiency when performing functionally.

We report conclusive evidence of an efficient cooling mechanism via the electronic radiative transitions of hot small molecular anions isolated in vacuum. We stored C6(-) and C6H(-) in an ion storage ring and observed laser-induced electron detachment with delays up to several milliseconds. The terminal hydrogen atom caused a drastic change in the decay profiles. The decay of photoexcited C6H(-) is slow and nonexponential, which can be explained by depletion cooling, whereas that for C6(-) occurs extremely fast, on a time scale below 0.1 ms and can only be explained by electronic radiative cooling via low-lying electronic excited states.

The present study directly addresses the roles of the P2X(7) receptor (P2X(7)R), an ionotropic adenosine triphosphate (ATP) receptor, and cytokines in the induction of orofacial pain following chronic constriction injury (CCI) of the infraorbital nerve (IoN).Rats were anesthetized, and ligatures of 4-0 chromic gut were tied around the IoN. A438079, a P2X(7)R antagonist or SB203580, a phosphorylated (p)-p38 mitogen-activated protein kinase (MAPK) inhibitor, was infused intrathecally into CCI-treated rats. In another group of rats, 3'-O-(4-benzoylbenzoyl) adenosine 5'-triphosphate (BzATP), a P2X(7) R agonist, was infused intrathecally with A438079, SB203580 or etanercept, a tumor necrosis factor (TNF)-α receptor-binding recombinant drug.CCI of the IoN induced tactile allodynia/hyperalgesia and up-regulation of P2X(7)R, membrane-bound TNF-α (mTNF-α) and soluble TNF-α (sTNF-α) in the trigeminal sensory nuclear complex (TNC). Tactile allodynia/hyperalgesia or up-regulation of mTNF-α and sTNF-α in the TNC following CCI of the IoN was inhibited by A438079. SB203580 also attenuated tactile allodynia/hyperalgesia or up-regulation of mTNF-α, but not the up-regulation of sTNF-α in the TNC. Treatment of rats with BzATP induced tactile allodynia/hyperalgesia and up-regulation of sTNF-α and p-p38 in the TNC. Tactile allodynia/hyperalgesia or up-regulation of sTNF-α following BzATP treatment was inhibited by SB203580 and etanercept.Based on these findings, phosphorylation of p38 MAPK via P2X(7)R may induce tactile allodynia/hyperalgesia, which is most likely mediated by sTNF-α released by microglia.

CANDLES is the project to search for neutrino-less double beta decay (0νββ) of βCa. The observation of 0νββ will prove existence of a massive Majorana neutrino. Now we installed new detector system CANDLES III. Here expected performances of the system for background rejection are presented. It is also described current status of development for the detector system.

Particle induced x-ray emission (PIXE) measurements were applied to analyze constituent elements in ancient earthenware (middle Jomon period) excavated at Teramae site in Fukushima prefecture. Quantitative analyses of the earthenware and clay obtained near the site show difference in contents of the constituent elements between them.

The observation of neutrino-less double beta decay (0νββ) will prove existence of a massive Majorana neutrino. For a sensitive measurement of the neutrino mass, we have developed a new detector system CANDLES, which features CaF 2 (pure) scintillators. The CANDLES system needs a low background measurement because 0νββ is a very rare decay. In order to reach the low background measurement, we introduced characteristic flash ADCs in the system. Besides the flash ADC, we developed a trigger system for the CaF 2 (pure) events. Signal processing for the data readout and trigger is in a FPGA. In this paper, we present the data acquisition system including the characteristic flash ADC and the trigger system for the CANDLES system.

CANDLES is the project to search for neutrinoless double beta (0νββ) decay of 48Ca by using CaF2 scintillators. The observation of 0νββ decay will prove the existence of massive Majorana neutrinos. Expected performances and current status of the CANDLES system are described.

Neutrino‐less double beta decay (0νββ) is currently known to be an only experiment to verify whether lepton number is conserved or not. The lepton number non‐conservation is the key to create matter dominated universe with CP violation. The so‐called leptogenesys scenario presents a way to create the matter dominated universe by these violations. If neutrinos have Majorana mass, transition from a particle to an anti‐particle is possible and the left‐handed and right‐handed neutrinos could have different masses. It is highly likely that the neutrinos are Majorana particles. We have been studying double beta decay of 48Ca. Our first stage experiment using the ELEGANT VI detector system gave the best lower limit of the half life of 0νββ of 48Ca. We have been working on CANDLES detector system to sense much longer lifetime region. We have developed techniques to reduce backgrounds. The CADLES detector system was installed at Kamioka underground laboratory. Here I describe a schematic view of the system.

Summary A serine protease from mite faecal extract, Dermatophagoides farinae, was purified using DEAE-Sephacel anion exchange chromatography and Supcrdex 75 pg gel chromato-graphy. The molecular weight of this protease was 34 kD on SDS-PAGE under reducing conditions. The optimal pH and temperature of the protease were 8-0 and 47 C, respectively. In addition, this protease cleaved arginyl or lysyl residue containing substrates selectively and was only inhibited by aprotinin, PUT-175, tind soy bean trypsin inhibitor and not by chymostatin, E-64 and iodoacetic acid. These results show that our purified serine protease belongs to the trypsin-type. Purified trypsin-like protease was shown to be allergenic by enzyme-linked immunosorbent assay. Antigeni-city of trypsin-like protease was completely different from those of Der f I and Der f II. Both, 20 N-terminal amino acid sequence and amino acid compositions of the purified protease were very similar to those of Der f III. Good similarities were found between trypsin-like protease and Der f III concerning physicochemical properties such as molecular weight on SDS-PAGE and ammonium sulphate solubility. Summarizing the above data, it can be concluded that a trypsin-like protease from mite faecal extract is actually the Der f III allergen and that it may be involved in the digestive process of the mite as it was found not in mite body but in mite faeces.

This work integrates robotics and electronic games with the objective of producing more motivating and attractive therapeutic activities in distal radius fracture rehabilitation (wrist region). The proposed robotic system allows the reliable measurement of all wrist angular motion amplitudes. To this end, a framework is proposed to allow the full integration of the designed game to the developed hardware. The framework stores data from the game and from the robot movements for further analysis. The prototype was tested in healthy subjects, and a questionnaire was used to produce qualitative impressions on the system.

CANDLES is the project to search for neutrino‐less double beta decay (0νββ) of 48Ca. The observation of 0νββ will prove existence of a massive Majorana neutrino. We have developed the new detector system CANDLES which features CaF2 (pure) scintillators. Here expected performances of the system for background rejection are presented. It is also described current status of development for the detector system.

The Japanese Guyots, Wake Guyots, and Mid-Pacific Mountains are part of a broad area of Cretaceous volcanism in the western Pacific termed the “Darwin Rise.” Based on Seabeam bathymetric data we classify these drowned volcanic islands as: type “A,” those that advanced to the atoll stage before final submergence; type “B,” those that drowned at the barrier reef stage; and type “V,” those with little or no reef material on their volcanic summits. Widespread evidence for karst topography extending to depths of 200 m on the summits of A and B guyots sheds new light on events leading to the synchronous extinction of reefs on the Darwin Rise in the mid-Cretaceous. We propose that after the formation of the reefs on the A and B guyots, the entire region was elevated at approximately the Aptian-Albian boundary (113 Ma) to form a superswell similar to that existing now in French Polynesia. The type V guyots formed on this anomalously shallow lithosphere. The demise of the reefs was the direct result of the rise of this superswell, although climate factors may have prevented reef recolonization following its later subsidence.

A series of ion storage experiments on small carbon cluster anions was conducted to understand size-dependent cooling processes. The laser-induced delayed electron detachment time profile show clear even/odd alternation due to the presence of the electronic cooling. The time evolution of the internal energy distribution was simulated for Cn- (n=4 to 7) with a common procedure taking vibrational and electronic cooling into account.

We describe the design, implementation and evaluation of a programmable architecture for profiling, composing and deploying handoff services. We argue that future wireless access networks should be built on a foundation of open programmable networking allowing for the dynamic deployment and management of new mobile and wireless services. Customizing handoff control and mobility management in this manner calls for advances in software and networking technologies in order to respond to specific radio, mobility, and quality of service requirements of future wireless service providers. Two applications of programmable handoff are presented. First, we describe "multi-service" access networks, which are capable of simultaneously supporting multiple styles of handoff over the same physical infrastructure. Second, we discuss "reflective handoff" which allows mobile devices to roam between heterogeneous networks.

CANDLES is the project to search for neutrino-less double beta decay (0νββ ) of 48 Ca. The observation of 0νββ will prove existence of a massive Majorana neutrino. For the 0νββ measurement, we need a low background condition because of a low decay rate of 0νββ . Now we installed the CANDLES III system at the Kamioka underground laboratory. The CANDLES III system realizes the low background condition by a characteristic structure and data analyses for background rejection. Here we report performances of the CANDLES III system.

This study evaluates the process of relapse after mandibular setback surgery by an analysis of the role of craniofacial morphology, hyoid position, pharyngeal airway and head posture. Subjects examined were 62 patients who received the sagittal split ramus osteotomies (SSRO). Changes of the craniofacial and related structures were evaluated from the serial cephalograms up to 3 years after the surgery. Results indicated that mandibular relapse represented by Pg occurred mostly within 6 months after the surgery. A net setback of the mandible was 9.1 mm and the superior move was 1.7 mm, with a reduction of 7.2 mm in mandibular length, 4.2 mm in ramus height, 3.7 mm in posterior face height, 2.6 degrees in gonial angle, an increase of 2.9 degrees in mandibular plane angle (MPA) by the last examination. Hyoid bone moved backward and downward and head posture was raised. The forward relapse of Pg was correlated with the changes of ANB, MPA, ramus height and hyoid position. Only hyoid position was predictably correlated with mandibular morphology and head posture. These findings suggest that mandibular setback alters the relationship among the hyoid position, pharyngeal airway and the head posture. It might be critical, therefore, relapse is closely monitored and controlled before the full healing of fragments and new muscular balance is established.

Disc displacement is accepted as one of major findings in temporomandibular disorders (TMD). However, the associations of disc positions with morphological and positional changes of temporomandibular joint (TMJ) components and lateral pterygoid (LP), TMD clinical symptoms, and occlusion have rarely been discussed quantitatively. In this study, the morphological and positional changes of TMJ components and LP were assessed by means of magnetic resonance imaging (MRI) and tomography of the TMJ in 41 TMD and nine control (CN) subjects. Disc positions in TMD subjects were divided into normal position (NP) and anterior displacement with and without reduction (ADR+ and ADR-, respectively). From MRI scans and tomograms, the morphological and positional changes of TMJ components and LP were measured and compared among CN, NP, ADR+ and ADR- groups. Correlations between these measurements and the scored clinical symptoms and occlusal factors were analysed in TMD subjects. The results indicated that: (1) TMJ osseous structures and LP showed no significant difference among CN and the three TMD groups, except for a posterior seat of condyle and shorter/steeper condylar movement during jaw opening; (2) disc length and inclination were significantly shorter and steeper, respectively, in ADR+ and ADR-; (3) disc positions were not specified by clinical symptoms and occlusal factors, except for the dominant TMJ sounds in ADR+; (4) an uncoordinated movement of the condyle/disc complex was found in ADR+ and/or ADR-; (5) TMJ osseous structures and the disc were weakly associated with clinical symptoms and occlusal factors. However, the LP showed negative associations with palpable pain for both the TMJ and jaw muscles and the static occlusal factors. These findings suggest that TMJ internal derangements are more related to the positional changes or spatial relationships of TMJ components but less to the individual morphologies of TMJ osseous structures, disc and LP, as well as specific clinical symptoms and occlusal factors, which might be in disagreement with a large body of previous statements.

The peptide possessing N-terminal 10 amino acid sequence of Cry j 2 was chemically synthesized and conjugated to KLH-carrier protein. Rabbits were immunized with this haptenized protein and the antibody (N-10 antibody) was obtained. Cross-blot analysis revealed that N-10 antibody recognized the hapten moiety. Purification of Cry j 2 was carried out with monitoring its reactivity with N-10 antibody. The substance reactive to N-10 antibody existed in the DEAE-Sephadex unadsorbed fraction. The substance reactive to N-10 antibody was subjected to CM-Sephadex equilibrated with 10 mM acetate buffer (pH 5.0). In contrast to the previous report on Cry j 2, the substance reactive to N-10 antibody existed in the CM-Sephadex unadsorbed fraction. The CM-Sephadex unadsorbed fraction was concentrated with 80% saturated ammonium sulfate, and applied to a Superdex pg 200 column. The major peak of protein was regarded as the final preparation and was subjected to SDS-PAGE. The substance reactive to N-10 antibody had a MW of 40 kDa under reducing and 37 kDa under non-reducing conditions, respectively. Furthermore, the substance reactive to N-10 antibody showed potent allergenic activity. These data completely agreed with the previous data on Cry j 2 and strongly suggested that the final preparation contained a large amount of Cry j 2. BALB/c mice were immunized intraperitoneally with the final preparation to produce a monoclonal antibody against Cry j 2. Eleven clones reacting to the final preparation were obtained, and the antibodies produced from these clones did not react with purified Cry j 1.(ABSTRACT TRUNCATED AT 250 WORDS)

We have examined the antigenic relationship between the house dust mite Dermatophagoides farinae and the predacious mite Phytoseiulus persimilis. Immunoblotting analysis demonstrated that there was a very weak antigenic cross-reactivity between these different suborder of mites but that this cross-reactivity was not attributed to D. farinaes major allergen's, Der fI and Der fII. These results suggest that P. persimilis might scarcely provoke allergic symptoms in patients sensitized to house dust mites.

CANDLES is a project to search for neutrinoless double beta decay of 48Ca using CaF2 scintillators. The observation of neutrinoless double beta decay would confirm the existence of massive Majorana neutrinos. Herein the expected performances and current status of the CANDLES system are described.

A 64-year-old male consulted our hospital with a 6-day history of malaise, body temperature to 38 degrees C, anorexia, and light headedness. The chest radiograph showed consolidation in the left lower lung area. Chest CT and ultrasonography revealed left pleural fluid. The pleural fluid was exudative (yellowish in color, protein 3.0 g/dl, Rivalta reaction positive, adenosine deaminase 19.4 U/L), and had a total cell count of 4.7 x 10(6)/ml with 45% lymphocytes, 40% histiocytes, and 15% polymorphonuclear leukocytes. He had kept a budgerigar, but we could not isolate Chlamydia from the pleural fluid or the pet bird. Transbronchial lung biopsy from left S10 revealed an increase of mononuclear leukocytes within the interstitial spaces, and the alveolar spaces contained polymorphonuclear leukocytes, fibrin, and organized alveolar exudate. Bronchoalveolar lavage cellular constituents were 50% lymphocytes, 27% neutrophils, and 23% macrophages. Serologic studies demonstrated C. trachomatis specific IgM antibody titers at 1:20 in a serum sample and at 1:10 in pleural fluid. We report a case of community-acquired pneumonia caused by C. trachomatis diagnosed by serologic studies.