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22 results on '"Gäbel, Markus"'

7. Livebirth after uterus transplantation

Author

Brännström, Mats, Johannesson, Liza, Bokström, Hans, Kvarnström, Niclas, Mölne, Johan, Dahm-Kähler, Pernilla, Enskog, Anders, Milenkovic, Milan, Ekberg, Jana, Diaz-Garcia, Cesar, Gäbel, Markus, Hanafy, Ash, Hagberg, Henrik, Olausson, Michael, and Nilsson, Lars

Published
2015
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12. Evaluation of reference genes for gene expression studies in human brown adipose tissue

Author

Taube, Magdalena, Andersson-Assarsson, Johanna C, Lindberg, Kristin, Pereira, Maria J, Gäbel, Markus, Svensson, Maria K, Eriksson, Jan W, Svensson, Per-Arne, Taube, Magdalena, Andersson-Assarsson, Johanna C, Lindberg, Kristin, Pereira, Maria J, Gäbel, Markus, Svensson, Maria K, Eriksson, Jan W, and Svensson, Per-Arne

Abstract

Human brown adipose tissue (BAT) has during the last 5 year been subjected to an increasing research interest, due to its putative function as a target for future obesity treatments. The most commonly used method for molecular studies of human BAT is the quantitative polymerase chain reaction (qPCR). This method requires normalization to a reference gene (genes with uniform expression under different experimental conditions, e.g. similar expression levels between human BAT and WAT), but so far no evaluation of reference genes for human BAT has been performed. Two different microarray datasets with samples containing human BAT were used to search for genes with low variability in expression levels. Seven genes (FAM96B, GNB1, GNB2, HUWE1, PSMB2, RING1 and TPT1) identified by microarray analysis, and 8 commonly used reference genes (18S, B2M, GAPDH, LRP10, PPIA, RPLP0, UBC, and YWHAZ) were selected and further analyzed by quantitative PCR in both BAT containing perirenal adipose tissue and subcutaneous adipose tissue. Results were analyzed using 2 different algorithms (Normfinder and geNorm). Most of the commonly used reference genes displayed acceptably low variability (geNorm M-values <0.5) in the samples analyzed, but the novel reference genes identified by microarray displayed an even lower variability (M-values <0.25). Our data suggests that PSMB2, GNB2 and GNB1 are suitable novel reference genes for qPCR analysis of human BAT and we recommend that they are included in future gene expression studies of human BAT.

Published
2015
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13. Live Birth After Uterus Transplantation

Author

Brännström, Mats, primary, Johannesson, Liza, additional, Bokström, Hans, additional, Kvarnström, Niclas, additional, Mölne, Johan, additional, Dahm-Kähler, Pernilla, additional, Enskog, Anders, additional, Milenkovic, Milan, additional, Ekberg, Jana, additional, Diaz-Garcia, Cesar, additional, Gäbel, Markus, additional, Hanafy, Ash, additional, Hagberg, Henrik, additional, Olausson, Michael, additional, and Nilsson, Lars, additional

Published
2015
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15. Fifteen years’ experience of intestinal and multivisceral transplantation in the Nordic countries

Author

Varkey, Jonas, primary, Simrén, Magnus, additional, Jalanko, Hannu, additional, Oltean, Mihai, additional, Saalman, Robert, additional, Gudjonsdottir, Audur, additional, Gäbel, Markus, additional, Borg, Helena, additional, Edenholm, Mats, additional, Bentdal, Oystein, additional, Husby, Steffen, additional, Staun, Michael, additional, Mäkisalo, Heikki, additional, Bosaeus, Ingvar, additional, Olausson, Michael, additional, Pakarinen, Mikko, additional, and Herlenius, Gustaf, additional

Published
2015
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16. First clinical uterus transplantation trial: a six-month report

Author

Brännström, Mats, primary, Johannesson, Liza, additional, Dahm-Kähler, Pernilla, additional, Enskog, Anders, additional, Mölne, Johan, additional, Kvarnström, Niclas, additional, Diaz-Garcia, Cesar, additional, Hanafy, Ash, additional, Lundmark, Cecilia, additional, Marcickiewicz, Janusz, additional, Gäbel, Markus, additional, Groth, Klaus, additional, Akouri, Randa, additional, Eklind, Saskia, additional, Holgersson, Jan, additional, Tzakis, Andreas, additional, and Olausson, Michael, additional

Published
2014
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17. A randomized, doubleblind, placebo-controlled, study of single-dose rituximab as induction in renal transplantation

Author

Tydén, Gunnar, Genberg, Helena, Tollemar, Jan, Ekberg, Henrik, Persson, Nils H., Tufveson, Gunnar, Wadström, Jonas, Gäbel, Markus, Mjörnstedt, Lars, Tydén, Gunnar, Genberg, Helena, Tollemar, Jan, Ekberg, Henrik, Persson, Nils H., Tufveson, Gunnar, Wadström, Jonas, Gäbel, Markus, and Mjörnstedt, Lars

Abstract

We performed a prospective, double blind, randomized, placebo-controlled multicenter study on the efficacy and safety of rituximab as induction therapy, together with tacrolimus, mycophenolate mofetil, and steroids. The primary endpoint was defined as acute rejection, graft loss, or death during the first 6 months. Secondary endpoints were creatinine clearance, incidence of infections, and incidence of rituximab-related adverse event. RESULTS: We enrolled 140 patients (44 living donor and 96 deceased donor), and of those, 68 rituximab and 68 placebo patients fulfilled the study. In all the patients receiving rituximab, there was a complete depletion of CD19/CD20 cells, whereas there was no change in the number of CD19/CD20 cells in the placebo group. There were 10 treatment failures in the rituximab group versus 14 in the placebo group (P=0.348). There were eight rejection episodes in the rituximab group versus 12 in the placebo group (P=0.317) Creatinine clearance was 66+/-22 mL/min in the study group and 67+/-23 mL/min in the placebo group. There was no difference in the number of bacterial infections, cytomegalovirus infections, and BK virus infections or fungal infections. CONCLUSION: We performed a placebo-controlled study of rituximab induction in renal transplantation. There was a tendency toward fewer and milder rejections during the first 6 months in the rituximab group. Although induction with one dose of rituximab induced a complete depletion B cells, there was no increase in the incidence of infectious complications or leukopenia and it seems safe, therefore, to conduct further studies on the use of rituximab in transplantation.

Published
2009
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21. Normothermic regional perfusion in controlled DCD liver procurement: Outcomes of the Swedish national implementation protocol.

Author

Bluhme E, Gäbel M, Martinez de la Maza L, Nilsén V, Hildebrand K, Jarsäter J, Bååth C, Proos M, Romano A, Villard C, Oniscu GC, Gustafsson N, Thompson M, Hansson C, Löfstedt M, Andersson Lindholm J, Falk L, Bennet W, and Jorns C

Abstract

Liver transplantation (LTX) using donors after controlled circulatory death (cDCD) is associated with poorer graft survival and increased incidence of nonanastomotic biliary strictures (NASs) compared to livers procured from brain-dead donors (DBD). The use of normothermic regional perfusion (NRP) during cDCD procurement may improve posttransplant outcomes and reduce the incidence of NAS. In Sweden, cDCD LTX was introduced through a national pilot protocol with mandatory NRP. This study aims to evaluate the outcome of cDCD LTX during the pilot period. Donor and recipient data were collected on all cDCD liver transplants during the pilot period between January 2020 to December 2022. Outcome on NAS, patient and graft survival, early allograft dysfunction, acute kidney injury, and comprehensive complication index was compared to a matched cohort of 28 patients transplanted with a DBD liver between 2018 and 2022. Eighteen patients were transplanted with a liver from a cDCD donor after using NRP. The mean functional warm ischemia time was 29 ± 6 minutes. The mean lactate reduction during NRP was 8.7 ± 2.4 mmol/L, and the end NRP perfusate alanine aminotransferase was 1.4 ± 1 µkat/L. When comparing recipients of cDCD liver transplant to DBD, no significant differences were observed in the incidence of NAS, patient and graft survival, comprehensive complication index, early allograft dysfunction, or acute kidney injury. Study protocol magnetic resonance cholangiopancreatography in cDCD patients showed no signs of subclinical biliary strictures. Evaluation of the Swedish national pilot of cDCD LTX with mandatory NRP shows comparable outcomes to a matched DBD cohort with 94.4% 1-year patient and graft survival and no incidence of NAS within the first year., (Copyright © The Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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22. [Promising results in intestinal transplantation].

Author

Gäbel M, Olausson M, Krantz M, and Herlenius G

Subjects
Adult, Child, Digestive System Surgical Procedures adverse effects, Graft Survival, Humans, Immunosuppression Therapy, Medical Illustration, Parenteral Nutrition adverse effects, Survival Rate, Waiting Lists mortality, Digestive System Surgical Procedures methods, Intestinal Diseases surgery, Intestines transplantation
Published
2012

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