1. Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human schistosomiasis
- Author
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Virmondes Rodrigues, Nasr Eldin Elwali, Yuesheng Li, Ogobara K. Doumbo, Laurent Argiro, Christophe Chevillard, Bourema Kouriba, Alain Dessein, Carole Eboumbou, Sandrine Marquet, Hélia Dessein, Génétique et immunologie des maladies parasitaires (GIMP), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Parasite Disease Group, Universidade do Porto [Porto]-Instituto de Biologia Molecular e Celular (IBMC)-Instituto de Investigação e Inovação em Saúde, Fédération de Recherche en Neurosciences (FR 3636), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Malaria Research and Training Center (MRTC), Faculté de Médecine de Bamako, Université de Douala, Immunologie et Génétique des Maladies Parasitaires [Aix Marseille Université] (IGMP - U399 Inserm - AMU), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de parasitologie-mycologie [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratory of Immunology, Universidade Federal do Triângulo Mineiro (UFTM), Hunan Institute of Parasitic Diseases, Universidade do Porto-Instituto de Biologia Molecular e Celular (IBMC)-Instituto de Investigação e Inovação em Saúde, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade do Porto = University of Porto-Instituto de Biologia Molecular e Celular (IBMC)-Instituto de Investigação e Inovação em Saúde, Génétique et immunologie des maladies parasitaires ( GIMP ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Fédération de Recherche en Neurosciences ( FR 3636 ), and Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS )
- Subjects
[SDV]Life Sciences [q-bio] ,Immunology ,Locus (genetics) ,Biology ,Interferon-gamma ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,[ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology ,Interferon ,Immunity ,medicine ,Animals ,Humans ,Schistosomiasis ,Immunology and Allergy ,Interferon gamma ,ComputingMilieux_MISCELLANEOUS ,Skin ,030304 developmental biology ,0303 health sciences ,Interleukin-13 ,Interleukin ,biology.organism_classification ,3. Good health ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Liver ,Interleukin 13 ,Schistosoma ,Schistosoma mansoni ,030215 immunology ,medicine.drug - Abstract
Immunity against schistosomes includes anti-infection immunity, which is mainly active against invading larvae in the skin, and anti-disease immunity, which controls abnormal fibrosis in tissues invaded by schistosome eggs. Anti-infection immunity is T-helper 2 (Th2) cell-dependent and is controlled by a major genetic locus that is located near the Th2 cytokine locus on chromosome 5q31-q33. Mutations in the gene encoding interleukin (IL)-13 that decrease or increase IL-13 production account, at least in part, for that genetic control. In contrast, protection against hepatic fibrosis is dependent on interferon (IFN)-gamma and is controlled by a major genetic locus that is located on 6q23, near the gene encoding the IFN-gamma receptor beta chain. Mutations that modulate IFN-gamma gene transcription are associated with different susceptibility to disease. These data indicate that IL-13 in the skin and IFN-gamma in the liver are key players in protective immunity against schistosomes. These roles relate to the high anti-fibrogenic activities of IFN-gamma and to the unique ability of IL-13 in Th2 priming in the skin and in the mobilization of eosinophils in tissues. The coexistence of strong IFN-gamma and IL-13-mediated immune responses in the same subject may involve the compartmentalization of the anti-schistosome immune response between the skin and the liver.
- Published
- 2004
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