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1. Immunogenicity of a third dose with mRNA-vaccines in the ChAdOx1-S/BNT162b2 vaccination regimen against SARS-CoV-2 variants

Author

García, Lucía Díaz, García, Elena Ramírez, Meseguer, Enrique Seco, Stewart Balbàs, Stefan Mark, Candón, Alicia Marín, García, Irene García, Elizalde, Mikel Urroz, Rosa, Paula de la, García, Marta Sanz, Crespo, Cristina López, Martínez, Vega Mauleón, de Madariaga Castell, Raquel, Vara, Laura Vitón, Prieto-Pérez, Rocío, Vargas-Castrillón, Emilio, Laredo, Leonor, Zhu-Huang, Ouhao, Iglesias, Teresa, Imaz-Ayo, Natale, Meijide, Susana, García de Vicuña, Aitor, Santorcuato, Ana, Exposito, Iraide, de Benito, Sara, Bustinza, Alazne, Gallego, Mikel, García-Vázquez, Dolores, Belén de la Hoz, Ana, Pérez-Nanclares, Gustavo, Aurrekoetxea, Josu, Urrutia, Ines, Martínez-Salazar, Rosa, Orcajo, Janire, Calvo, Begoña, Corcuera, June, Velasco, Olaia, Aguayo, Anibal, Martínez-Gómez, Xavier, Otero-Romero, Susana, Armadans, Lluis, Borras-Bermejo, Blanca, Parés, Oleguer, Uriona, Sonia, Rodrigo Pendás, José Ángel, Llorente, Cesar, Santos, José, Pinós, Laia, Camacho, Lina, Riera, Judith, Sans, Carla, Agustí, Antonia, Altadill, Carmen, Blancafort, Carla Aguilar, Serrat, Gisela Gili, Plaza, Aitana, Prius, Anna Feliu, Torrens, Maria Margarita, Palacio, Esther, Torres, Gloria, Calonge, Julia, Alins, Elena Ballarin, Pérez-Esquirol, Eulàlia, Bosch, Lourdes Vendrell, Aldea, Marta, Mellado, Eugènia, Marcos, M<ce:sup loc='post">a</ce:sup> Ángeles, Tortajada, Marta, Barón-Mira, Lourdes E., Granés, Laura, Lazaar, Sulayman, Herranz, Sara, Malet, Montserrat, Quesada, Sebastiana, Llupià, Anna, Olivé, Victoria, Trilla, Antoni, Gómez, Begoña, González, Elisenda, Romero, Sheila, Gámez, Francisco Javier, Casals, Cristina, Burunat, Laura, Castelló, Juan José, Fernández, Patricia, Bedini, Josep Lluís, Vila, Jordi, Hurtado, Juan Carlos, Jado, Isabel, Fedele, Giovanni, Perea, Concepción, González, Mónica, Grajera, Isabel, Murillo, María Ángeles, Balfagón, Pilar, Díaz-Marín, Irene, González-Pardo, Gema, García-Pérez, Javier, Borobia, Alberto M., Pérez-Olmeda, Mayte, Portolés, Antonio, Castaño, Luis, Campins-Artí, Magdalena, Bertrán, María Jesús, Bermejo, Mercedes, Arribas, José Ramón, López, Andrea, Ascaso-del-Rio, Ana, Arana-Arri, Eunate, Fuentes Camps, Inmaculada, Vilella, Anna, Cascajero, Almudena, García-Morales, María Teresa, Castillo de la Osa, María, Pérez Ingidua, Carla, Lora, David, Jiménez-Santana, Paloma, Pino-Rosa, Silvia, Gómez de la Cámara, Agustín, De La Torre-Tarazona, Erick, Calonge, Esther, Cruces, Raquel, Belda-Iniesta, Cristóbal, Alcamí, José, Frías, Jesús, Carcas, Antonio J., and Díez-Fuertes, Francisco

Published
2024
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3. Immunogenic dynamics and SARS-CoV-2 variant neutralisation of the heterologous ChAdOx1-S/BNT162b2 vaccination: Secondary analysis of the randomised CombiVacS study

Author

García-Pérez, Javier, González-Pérez, María, Castillo de la Osa, María, Borobia, Alberto M., Castaño, Luis, Bertrán, María Jesús, Campins, Magdalena, Portolés, Antonio, Lora, David, Bermejo, Mercedes, Conde, Patricia, Hernández-Gutierrez, Lourdes, Carcas, Antonio, Arana-Arri, Eunate, Tortajada, Marta, Fuentes, Inmaculada, Ascaso, Ana, García-Morales, María Teresa, Erick de la Torre-Tarazona, Humberto, Arribas, José-Ramón, Imaz-Ayo, Natale, Mellado-Pau, Eugènia, Agustí, Antonia, Pérez-Ingidua, Carla, Gómez de la Cámara, Agustín, Ochando, Jordi, Belda-Iniesta, Cristobal, Frías, Jesús, Alcamí, José, and Pérez-Olmeda, Mayte

Published
2022
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5. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial

Author

Martínez de Soto, Lucía, Rodríguez Mariblanca, Amelia, Díaz García, Lucía, Ramírez García, Elena, Seco Meseguer, Enrique, Stewart Balbás, Stefan Mark, Marín Candón, Alicia, García García, Irene, Urroz Elizalde, Mikel, Monserrat Villatoro, Jaime, de la Rosa, Paula, Sanz García, Marta, López Crespo, Cristina, Mauleón Martínez, Vega, de Madariaga Castell, Raquel, Vitón Vara, Laura, García Rodríguez, Julio, Buño, Antonio, López Granados, Eduardo, Cámara, Carmen, Rey Cuevas, Esther, Ayllon García, Pilar, Jiménez González, María, Hernández Rubio, Victoria, Moraga Alapont, Paloma, Sánchez, Amparo, Prieto, Rocío, Llorente Gómez, Silvia, Miragall Roig, Cristina, Aparicio Marlasca, Marina, de la Calle, Fernando, Arsuaga, Marta, Duque, Blanca, Meijide, Susana, García de Vicuña, Aitor, Santorcuato, Ana, Expósito, Iraide, de Benito, Sara, Andia, Joseba, Castillo, Cristina, Irurzun, Esther, Camino, Jesús, Temprano, Mikel, Goikoetxea, Josune, Bustinza, Alazne, Larrea, Maialen, Gallego, Mikel, García-Vázquez, Dolores, de la Hoz, Ana Belén, Pérez-Nanclares, Gustavo, Pérez-Guzmán, Estíbaliz, Idoyaga, Eneko, Lamela, Adriana, Oteo, Jesús, Castillo de la Osa, María, Hernández Gutiérrez, Lourdes, Andrés Galván, María Elena, Calonge, Esther, Bermejo, Mercedes, de la Torre-Tarazona, Erick Humberto, Cascajero, Almudena, Fedele, Giovanni, Perea, Concepción, Cervera, Isabel, Bodega-Mayor, Irene, Montes-Casado, María, Portolés, Pilar, Baranda, Jana, Granés, Laura, Lazaar, Sulayman, Herranz, Sara, Mellado, María Eugènia, Tortajada, Marta, Malet, Montserrat, Quesada, Sebastiana, Vilella, Anna, Llupià, Anna, Olivé, Victoria, Trilla, Antoni, Gómez, Begoña, González, Elisenda, Romero, Sheila, Gámez, Francisco Javier, Casals, Cristina, Burunat, Laura, Castelló, Juan José, Fernández, Patricia, Bedini, Josep Lluís, Vila, Jordi, Aguilar, Carla, Altadill, Carmen, Armadans, Lluis, Borras-Bermejo, Blanca, Calonge, Julia, Camacho, Lina, Feliu, Anna, Gili, Gisela, Llorente, Cesar, Martínez-Gómez, Xavier, Otero-Romero, Susana, Palacio, Esther, Parés, Oleguer, Pinós, Laia, Plaza, Aitana, Riera-Arnau, Judit, Rodrigo-Pendás, José Angel, Sans, Carla, Santos, José, Torres, Gloria, Torrens, Margarita, Uriona, Sonia, Ballarin Alins, Elena, Pérez Esquirol, Eulàlia, Vendrell Bosch, Lourdes, Laredo Velasco, Leonor, Uribe López, Diana, González Rojano, Esperanza, Sánchez-Craviotto, Manuel, Rivas Paterna, Ana Belén, Hernán-Gómez, Teresa Iglesias, Rodríguez Galán, Natalia, Gil Marín, José Antonio, Álvarez-Morales, Verónica, Navalpotro, Ana Belén, Jiménez-Santamaría, M Dolores, Cardós, M Carmen, Hermoso, Elena, García-Arenillas, Mar, Pérez Macías, Natalia, Domingo Fernández, Alexandra, López Picado, Amanda, Quiñones, Jorge Mario, Deidda, Nicoletta, García-Franco, Ana, Torvisco, José María, Borobia, Alberto M, Carcas, Antonio J, Pérez-Olmeda, Mayte, Castaño, Luis, Bertran, María Jesús, García-Pérez, Javier, Campins, Magdalena, Portolés, Antonio, González-Pérez, María, García Morales, María Teresa, Arana-Arri, Eunate, Aldea, Marta, Díez-Fuertes, Francisco, Fuentes, Inmaculada, Ascaso, Ana, Lora, David, Imaz-Ayo, Natale, Barón-Mira, Lourdes E, Agustí, Antonia, Pérez-Ingidua, Carla, Gómez de la Cámara, Agustín, Arribas, José Ramón, Ochando, Jordi, Alcamí, José, Belda-Iniesta, Cristóbal, and Frías, Jesús

Published
2021
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7. Ivabradina para el control crónico de la frecuencia cardiaca en fibrilación auricular permanente. Diseño del proyecto BRAKE-AF

Author

Fontenla, Adolfo, López-Gil, María, Tamargo-Menéndez, Juan, Matía-Francés, Roberto, Salgado-Aranda, Ricardo, Rey-Blas, Juan Ramón, Miracle-Blanco, Ángel, Mejía-Martínez, Elena, Pastor-Fuentes, Agustín, Toquero-Ramos, Jorge, Arias, Miguel Ángel, Montilla, Isabel, Gómez de la Cámara, Agustín, and Arribas, Fernando

Published
2020
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8. Variabilidad geográfica y temporal del consumo de ultraprocesados y mortalidad asociada en España

Author

Gómez de la Cámara, Agustín Ramón, Romero Ferreiro, María del Carmen, Gómez de la Cámara, Agustín Ramón, and Romero Ferreiro, María del Carmen

Abstract

Los hábitos dietéticos han cambiado en las últimas décadas. Uno de los cambios más importantes es el aumento del consumo de alimentos ultraprocesados en todo el mundo. Los alimentos ultraprocesados (UPF, por sus siglas en inglés) son preparaciones industriales elaboradas a partir de sustancias obtenidas de los alimentos o sintetizadas directamente en laboratorios, y suelen contener poco o ningún alimento completo. Estos productos suelen contener altas cantidades de grasa, sal o azúcar y poca fibra, lo que los convierte en alimentos de baja calidad nutricional. Los últimos hallazgos disponibles sugieren que su alta disponibilidad y variedad, junto con el bajo coste, las estrategias de marketing y publicidad empleadas por las marcas y la falta de regulación legislativa, ha llevado a una ingesta excesiva de estos alimentos. Los UPF se han asociado a un mayor riesgo de enfermedades no transmisibles (ENT), como son la obesidad, las enfermedades cardiovasculares y el cáncer, así como a la mortalidad por cualquier causa. Dado que estos alimentos se han convertido en una importante fuente de energía en algunas poblaciones, es necesario limitar su consumo mediante medidas de salud pública y garantizar que la población es capaz de identificarlos. Una de las herramientas utilizadas para promover opciones dietéticas saludables es el etiquetado nutricional. Actualmente existen varias etiquetas, aunque la más utilizada es el Nutri-Score. El problema de este etiquetado radica en que no tiene en cuenta el nivel de procesamiento para categorizar los alimentos y por tanto no hacen recomendaciones basadas en esta dimensión. Actualmente, existe poca información sobre el consumo de alimentos ultraprocesados en España, así como su relación con la mortalidad y su etiquetado. Los estudios presentados en esta tesis intentan cubrir algunas de las lagunas existentes en este campo..., Dietary habits have changed in recent decades. One of the most important changes is the increase in the ultra-processed foods consumption all around the world. Ultra-processed foods (UPFs) are industrial formulations made from substances derived from food or synthesized in laboratories, usually containing little or no whole food. These foods often contain high amounts of fats, salt or sugar and low fiber, making them foods of low nutritional quality. Evidence suggests that it is the high availability and variety, low cost, the marketing and advertising strategies employed by brands and the lack of legislative regulation, that has led to excessive intake. Besides UPFs have been also associated with an increased risk of non-communicable diseases (NCDs), such as obesity, cardiovascular diseases and cancer as well as all-cause mortality. As these foods have become an important source of energy in some populations, it is necessary to limit their consumption through public health actions and to ensure that the population can identify them. One of the tools used to promote healthy dietary choices is nutrition labelling. There are currently several labels, although the most popular is the Nutri-Score. This label does not take into account the level of processing and does not make recommendations based on this classification. To sum up, there is limited information on the consumption of ultra-processed foods in Spain, their relationship with mortality and their labelling. The studies presented in this thesis attempt to fill some of the gaps in this field...

Published
2024

9. Prediction of individual lifetime cardiovascular risk and potential treatment benefit:Development and recalibration of the LIFE-CVD2 model to four European risk regions

Author

Hageman, Steven H.J., Kaptoge, Stephen, De Vries, Tamar I., Lu, Wentian, Kist, Janet M., Van Os, Hendrikus J.A., Numans, Mattijs E., Läll, Kristi, Bobak, Martin, Pikhart, Hynek, Kubinova, Ruzena, Malyutina, Sofia, Pająk, Andrzej, Tamosiunas, Abdonas, Erbel, Raimund, Stang, Andreas, Schmidt, Börge, Schramm, Sara, Bolton, Thomas R., Spackman, Sarah, Bakker, Stephan J.L., Blaha, Michael, Boer, Jolanda M.A., Bonnefond, Amélie, Brenner, Hermann, Brunner, Eric J., Cook, Nancy R., Davidson, Karina, Dennison, Elaine, Donfrancesco, Chiara, Dörr, Marcus, Floyd, James S., Ford, Ian, Fu, Michael, Gansevoort, Ron T., Giampaoli, Simona, Gillum, Richard F., Gómez-De-La-Cámara, Agustín, Håheim, Lise Lund, Hansson, Per Olof, Harms, Peter, Humphries, Steve E., Ikram, M. Kamran, Jukema, J. Wouter, Kavousi, Maryam, Kiechl, Stefan, Kucharska-Newton, Anna, Pablos, David Lora, Matsushita, Kunihiro, Meyer, Haakon E., Moons, Karel G.M., Mortensen, Martin Bødtker, Muilwijk, Mirthe, Nordestgaard, Børge G., Packard, Chris, Pamieri, Luigi, Panagiotakos, Demosthenes, Peters, Annette, Potier, Louis, Providencia, Rui, Psaty, Bruce M., Ridker, Paul M., Rodriguez, Beatriz, Rosengren, Annika, Sattar, Naveed, Schöttker, Ben, Schwartz, Joseph E., Shea, Steven, Shipley, Martin J., Sofat, Reecha, Thorand, Barbara, Verschuren, W. M.Monique, Völzke, Henry, Wareham, Nicholas J., Westbury, Leo, Willeit, Peter, Zhou, Bin, Danesh, John, Visseren, Frank L.J., Di Angelantonio, Emanuele, Pennells, Lisa, Dorresteijn, Jannick A.N., Hageman, Steven H.J., Kaptoge, Stephen, De Vries, Tamar I., Lu, Wentian, Kist, Janet M., Van Os, Hendrikus J.A., Numans, Mattijs E., Läll, Kristi, Bobak, Martin, Pikhart, Hynek, Kubinova, Ruzena, Malyutina, Sofia, Pająk, Andrzej, Tamosiunas, Abdonas, Erbel, Raimund, Stang, Andreas, Schmidt, Börge, Schramm, Sara, Bolton, Thomas R., Spackman, Sarah, Bakker, Stephan J.L., Blaha, Michael, Boer, Jolanda M.A., Bonnefond, Amélie, Brenner, Hermann, Brunner, Eric J., Cook, Nancy R., Davidson, Karina, Dennison, Elaine, Donfrancesco, Chiara, Dörr, Marcus, Floyd, James S., Ford, Ian, Fu, Michael, Gansevoort, Ron T., Giampaoli, Simona, Gillum, Richard F., Gómez-De-La-Cámara, Agustín, Håheim, Lise Lund, Hansson, Per Olof, Harms, Peter, Humphries, Steve E., Ikram, M. Kamran, Jukema, J. Wouter, Kavousi, Maryam, Kiechl, Stefan, Kucharska-Newton, Anna, Pablos, David Lora, Matsushita, Kunihiro, Meyer, Haakon E., Moons, Karel G.M., Mortensen, Martin Bødtker, Muilwijk, Mirthe, Nordestgaard, Børge G., Packard, Chris, Pamieri, Luigi, Panagiotakos, Demosthenes, Peters, Annette, Potier, Louis, Providencia, Rui, Psaty, Bruce M., Ridker, Paul M., Rodriguez, Beatriz, Rosengren, Annika, Sattar, Naveed, Schöttker, Ben, Schwartz, Joseph E., Shea, Steven, Shipley, Martin J., Sofat, Reecha, Thorand, Barbara, Verschuren, W. M.Monique, Völzke, Henry, Wareham, Nicholas J., Westbury, Leo, Willeit, Peter, Zhou, Bin, Danesh, John, Visseren, Frank L.J., Di Angelantonio, Emanuele, Pennells, Lisa, and Dorresteijn, Jannick A.N.

Abstract

Aims: The 2021 European Society of Cardiology prevention guidelines recommend the use of (lifetime) risk prediction models to aid decisions regarding initiation of prevention. We aimed to update and systematically recalibrate the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model to four European risk regions for the estimation of lifetime CVD risk for apparently healthy individuals. Methods and results: The updated LIFE-CVD (i.e. LIFE-CVD2) models were derived using individual participant data from 44 cohorts in 13 countries (687 135 individuals without established CVD, 30 939 CVD events in median 10.7 years of follow-up). LIFE-CVD2 uses sex-specific functions to estimate the lifetime risk of fatal and non-fatal CVD events with adjustment for the competing risk of non-CVD death and is systematically recalibrated to four distinct European risk regions. The updated models showed good discrimination in external validation among 1 657 707 individuals (61 311 CVD events) from eight additional European cohorts in seven countries, with a pooled C-index of 0.795 (95% confidence interval 0.767-0.822). Predicted and observed CVD event risks were well calibrated in population-wide electronic health records data in the UK (Clinical Practice Research Datalink) and the Netherlands (Extramural LUMC Academic Network). When using LIFE-CVD2 to estimate potential gain in CVD-free life expectancy from preventive therapy, projections varied by risk region reflecting important regional differences in absolute lifetime risk. For example, a 50-year-old smoking woman with a systolic blood pressure (SBP) of 140 mmHg was estimated to gain 0.9 years in the low-risk region vs. 1.6 years in the very high-risk region from lifelong 10 mmHg SBP reduction. The benefit of smoking cessation for this individual ranged from 3.6 years in the low-risk region to 4.8 years in the very high-risk region. Conclusion: By taking into account geographical differences in CVD incidence using contempor

Published
2024

10. Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

Author

Wood, Angela M, Kaptoge, Stephen, Butterworth, Adam, Willeit, Peter, Warnakula, Samantha, Bolton, Thomas, Paige, Ellie, Paul, Dirk S, Sweeting, Michael, Burgess, Stephen, Bell, Steven, Astle, William, Stevens, David, Koulman, Albert, Selmer, Randi M, Verschuren, Monique, Sato, Shinichi, Njølstad, Inger, Woodward, Mark, Veikko, Salomaa, Nordestgaard, Børge G, Yeap, Bu B, Flecther, Astrid, Melander, Olle, Kuller, Lewis H, Balkau, Beverley, Marmot, Michael, Koenig, Wolfgang, Casiglia, Edoardo, Cooper, Cyrus, Arndt, Volker, Franco, Oscar H, Wennberg, Patrik, Gallacher, John, Gómez de la Cámara, Agustín, Völzke, Henry, Dahm, Christina C, Dale, Caroline E, Bergmann, Manuela, Crespo, Carlos, van der Schouw, Yvonne T, Kaaks, Rudolf, Simons, Leon A, Lagiou, Pagona, Schoufour, Josje D, Boer, Jolanda M.A, Key, Timothy J, Rodriguez, Beatriz, Moreno-Iribas, Conchi, Davidson, Karina W, Taylor, James O, Sacerdote, Carlotta, Wallace, Robert B, Quiros, J. Ramon, Rimm, Eric B, Tumino, Rosario, Blazer III, Dan G, Linneberg, Allan, Daimon, Makoto, Panico, Salvatore, Howard, Barbara, Skeie, Guri, Salomaa, Veikko, Strandberg, Timo, Weiderpass, Elisabete, Nietert, Paul J, Psaty, Bruce M, Kromhout, Daan, Salamanca-Fernandez, Elena, Kiechl, Stefan, Krumholz, Harlan M, Grioni, Sara, Palli, Domenico, Huerta, José M, Price, Jackie, Sundström, Johan, Arriola, Larraitz, Arima, Hisatomi, Travis, Ruth C, Panagiotakos, Demosthenes B, Karakatsani, Anna, Trichopoulou, Antonia, Kühn, Tilman, Grobbee, Diederick E, Barrett-Connor, Elizabeth, van Schoor, Natasja, Boeing, Heiner, Overvad, Kim, Kauhanen, Jussi, Wareham, Nick, Langenberg, Claudia, Forouhi, Nita, Wennberg, Maria, Després, Jean-Pierre, Cushman, Mary, Cooper, Jackie A, Rodriguez, Carlos J, Sakurai, Masaru, Shaw, Jonathan E, Knuiman, Matthew, Voortman, Trudy, Meisinger, Christa, Tjønneland, Anne, Brenner, Hermann, Palmieri, Luigi, Dallongeville, Jean-Pierre, Brunner, Eric J, Assmann, Gerd, Trevisan, Maurizio, Gillumn, Richard F, Ford, Ian Ford, Sattar, Naveed, Lazo, Mariana, Thompson, Simon, Ferrari, Pietro, Leon, David A, Davey Smith, George, Peto, Richard, Jackson, Rod, Banks, Emily, Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S, Verschuren, W M Monique, Fletcher, Astrid, de la Cámara, Agustín Gómez, Bergmann, Manuela M, Crespo, Carlos J, Boer, Jolanda M A, Quiros, J Ramon, Blazer, Dan G, II, Dallongeville, Jean, Gillum, Richard F, Ford, Ian, Thompson, Simon G, and Smith, George Davey

Published
2018
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11. Validity Assessment of Low-risk SCORE Function and SCORE Function Calibrated to the Spanish Population in the FRESCO Cohorts

Author

Baena-Díez, José Miguel, Subirana, Isaac, Ramos, Rafael, Gómez de la Cámara, Agustín, Elosua, Roberto, Vila, Joan, Marín-Ibáñez, Alejandro, Guembe, María Jesús, Rigo, Fernando, Tormo-Díaz, María José, Moreno-Iribas, Conchi, Cabré, Joan Josep, Segura, Antonio, Lapetra, José, Quesada, Miquel, Medrano, María José, González-Diego, Paulino, Frontera, Guillem, Gavrila, Diana, Ardanaz, Eva, Basora, Josep, García, José María, García-Lareo, Manel, Gutiérrez-Fuentes, José Antonio, Mayoral, Eduardo, Sala, Joan, Dégano, Irene R., Francès, Albert, Castell, Conxa, Grau, María, and Marrugat, Jaume

Published
2018
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12. Evaluación de la validez de las funciones SCORE de bajo riesgo y calibrada para población española en las cohortes FRESCO

Author

Baena-Díez, José Miguel, Subirana, Isaac, Ramos, Rafael, Gómez de la Cámara, Agustín, Elosua, Roberto, Vila, Joan, Marín-Ibáñez, Alejandro, Guembe, María Jesús, Rigo, Fernando, Tormo-Díaz, María José, Moreno-Iribas, Conchi, Cabré, Joan Josep, Segura, Antonio, Lapetra, José, Quesada, Miquel, Medrano, María José, González-Diego, Paulino, Frontera, Guillem, Gavrila, Diana, Ardanaz, Eva, Basora, Josep, García, José María, García-Lareo, Manel, Gutiérrez-Fuentes, José Antonio, Mayoral, Eduardo, Sala, Joan, Dégano, Irene R., Francès, Albert, Castell, Conxa, Grau, María, and Marrugat, Jaume

Published
2018
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18. Epidemiology of the Toxic Oil Syndrome

Author

Philen, Rossanne M., Posada de la Paz, Manuel, Hill, Robert H., Schurz, Helen H., Borda, Ignacio Abaitua, Gómez de la Cámara, Agustín, Kilbourne, Edwin M., Seiler, Jürg P., editor, and Vilanova, Eugenio, editor

Published
1997
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19. Stability of SARS-CoV-2 spike antigens against mutations

Author

European Commission, Natural Sciences and Engineering Research Council of Canada, Eusko Jaurlaritza, Universidad del País Vasco, De la Fuente, Ildefonso M. [0000-0001-6548-7583], Malaina, Iker [0000-0002-1305-6623], Carrasco-Pujante, J. [0000-0001-6490-738X], De la Fuente, Ildefonso M., Malaina, Iker, Fedetz, María, Chruszcz, Maksymilian, Grandes, Gontzal, Lozano-Pérez, Antonio A., Shteyer, Eyal, Ya'akov, Ami Ben, Gómez de la Cámara, Agustín, Borobia, Alberto M., Carrasco-Pujante, J., Pijoan, José Ignacio, Bringas, Carlos, Pérez-Yarza, G., Ouro, Alberto, Crawford, Michael J., Shoshan-Barmatz, Varda, Zhurov, Vladimir, López, Jose I., Knafo, Shira, Tary-Lehmann, Magdalena, Gabaldón, Toni, Grbić, Miodrag, European Commission, Natural Sciences and Engineering Research Council of Canada, Eusko Jaurlaritza, Universidad del País Vasco, De la Fuente, Ildefonso M. [0000-0001-6548-7583], Malaina, Iker [0000-0002-1305-6623], Carrasco-Pujante, J. [0000-0001-6490-738X], De la Fuente, Ildefonso M., Malaina, Iker, Fedetz, María, Chruszcz, Maksymilian, Grandes, Gontzal, Lozano-Pérez, Antonio A., Shteyer, Eyal, Ya'akov, Ami Ben, Gómez de la Cámara, Agustín, Borobia, Alberto M., Carrasco-Pujante, J., Pijoan, José Ignacio, Bringas, Carlos, Pérez-Yarza, G., Ouro, Alberto, Crawford, Michael J., Shoshan-Barmatz, Varda, Zhurov, Vladimir, López, Jose I., Knafo, Shira, Tary-Lehmann, Magdalena, Gabaldón, Toni, and Grbić, Miodrag

Abstract

Modern health care needs preventive vaccines and therapeutic treatments with stability against pathogen mutations to cope with current and future viral infections. At the beginning of the COVID-19 pandemic, our analytic and predictive tool identified a set of eight short SARS-CoV-2 S-spike protein epitopes that had the potential to persistently avoid mutation. Here a combination of genetic, Systems Biology and protein structure analyses confirm the stability of our identified epitopes against viral mutations. Remarkably, this research spans the whole period of the pandemic, during which 93.9% of the eight peptides remained invariable in the globally predominant 43 circulating variants, including Omicron. Likewise, the selected epitopes are conserved in 97% of all 1,514 known SARS-CoV-2 lineages. Finally, experimental analyses performed with these short peptides showed their specific immunoreactivity. This work opens a new perspective on the design of next-generation vaccines and antibody therapies that will remain reliable against future pathogen mutations.

Published
2022

20. Machine learning uncovers blood test patterns subphenotypes at hospital admission discerning increased 30-day ICU mortality rates in COVID-19 elderly patients

Author

Zhou, Lexin, primary, Romero-García, Nekane, additional, Badenes, Rafael, additional, Morales, Teresa García, additional, Lora, David, additional, Gómez de la Cámara, Agustín, additional, García Ruiz, Francisco T, additional, García-Gómez, Juan M, additional, and Sáez, Carlos, additional

Published
2022
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22. Immunogenic Dynamics and SARS-CoV-2 Variants Neutralization of the Heterologous ChAdOx1-S/BNT162b2 Vaccination: Secondary Analysis of the CombiVacS Study

Author

Alcamí Pertejo, José, primary, García-Pérez, Javier, additional, Gonzalez-Perez, Maria, additional, Castillo de la Osa, María, additional, Borobia, Alberto M, additional, Castaño, Luis, additional, Jesús Bertrán, María, additional, Campins, Magdalena, additional, Portolés, Antonio, additional, Lora, David, additional, Bermejo, Mercedes, additional, Conde, Patricia, additional, Hernández Gutiérrez, Lourdes, additional, Carcas, Antonio J, additional, Arana-Arr, Eunate, additional, Tortajada, Marta, additional, Fuentes-Camps, Inmaculada, additional, Ascaso, Ana, additional, García-Morales, María Teresa, additional, de la Torre-Tarazona, Humberto Erick, additional, Arribas, José-Ramón, additional, Imaz-Ayo, Natale, additional, Mellado-Pau, Eugènia, additional, Agustí, Antonia, additional, Pérez-Ingidua, Carla, additional, Gómez de la Cámara, Agustín, additional, Ochando, Jordi, additional, Belda-Iniesta, Cristóbal, additional, Frías, Jesús, additional, Pérez-Olmeda, Mayte, additional, and Group, CombiVacS Study, additional

Published
2022
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23. Immunogenic Dynamics and SARS-CoV-2 Variants Neutralization of the Heterologous ChAdOx1-S/BNT162b2 Vaccination: Secondary Analysis of the CombiVacS Study

Author

García-Pérez, Javier, primary, González-Pérez, Maria, additional, Castillo de la Osa, María, additional, Borobia, Alberto M, additional, Castaño, Luis, additional, Jesús Bertrán, María, additional, Campins, Magdalena, additional, Portolés, Antonio, additional, Lora, David, additional, Bermejo, Mercedes, additional, Conde, Patricia, additional, Hernández Gutiérrez, Lourdes, additional, Carcas, Antonio J, additional, Arana, Eunate, additional, Tortajada, Marta, additional, Fuentes-Camps, Inmaculada, additional, Ascaso, Ana, additional, García Morales, María Teresa, additional, de la Torre-Tarazona, Humberto Erick, additional, Arribas, JR, additional, Imaz-Ayo, Natale, additional, Mellado-Pau, Eugènia, additional, Agustí, Antonia, additional, Pérez-Ingidua, Carla, additional, Gómez de la Cámara, Agustín, additional, ochando, jordi, additional, Belda-Iniesta, Cristóbal, additional, Frías, Jesús, additional, Pérez Olmeda, María Teresa, additional, Alcamí Pertejo, José, additional, and Group, CombiVacS Study, additional

Published
2022
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24. Concordancia entre los porcentajes de grasa corporal estimados mediante el área adiposa del brazo, el pliegue del tríceps y por impedanciometría brazo-brazo

Author

Martín Moreno Vicente, Gómez Gandoy Juan Benito, Antoranz González María Jesús, and Gómez de la Cámara Agustín

Subjects
Impedancia bioeléctrica, Antropometría, Composición corporal, Evaluación nutricional, Grosor de pliegues cutaneos, Medicine, Public aspects of medicine, RA1-1270
Abstract

Fundamento: La valoración del estado nutricional a partir de los miembros superiores es útil a nivel clínico. El objetivo de este trabajo es analizar el grado de acuerdo entre los porcentajes de grasa corporal (%GC) estimados mediante el área adiposa del brazo (%GC BRAZO), la ecuación de Siri para el pliegue del tríceps (%GC TRÍCEPS) y por bioimpedanciometría brazo-brazo (%GC BIA), así como con la ecuación de Siri para cuatro pliegues (%GC SIRI). Métodos: Estudio descriptivo transversal. Se valoró antropométricamente y por impedanciometría (Omron BF 300©) a 145 personas (83 varones, 62 mujeres). La concordancia entre métodos se analizó mediante el coeficiente de correlación intraclase (CCI) y el método de Bland-Altman. Resultados: el CCI entre %GC BRAZO-%GC TRÍCEPS fue de 0,8322 (intervalo de confianza al 95% 0,7672-0,8791); entre %GCB RAZO-%GC BIA de 0,7337 (0,6305-0,8080) y entre %GC TRICEPS-%GC BIA de 0,9290 (0,9015; 0,9488). Con el método de Bland-Altman el intervalo de concordancia entre %GC BRAZO-%GC TRÍCEPS (-11,2; 16,96) y entre %GC BRAZO-%GC BIA (-13,04; 21,76) superó el punto de corte (±10%), pero no entre %G CTRICEPS-%GC BIA (-6,64; 9,6), %GC SIRI-%GC TRÍCEPS (-5,27; 4,52) y %GC SIRI-%GC BIA (-6,31; 8,52). El IMC no influyó en el resultado. Conclusiones: El método utilizado influye en la valoración nutricional realizada a partir de los miembros superiores. El área adiposa del brazo sobreestima el %GC con relación a la ecuación de Siri para el pliegue del tríceps o para cuatro pliegues y a la impedanciometría, y aunque este resultado sugiere que el área adiposa del brazo puede no ser un indicador válido de la adiposidad global, este extremo deberá ser confirmado frente a una técnica patrón.

Published
2003

25. Grasa corporal e índice adiposo-muscular estimados mediante impedanciometría en la evaluación nutricional de mujeres de 35 a 55 años

Author

Martín Moreno Vicente, Gómez Gandoy Juan Benito, Gómez de la Cámara Agustín, and Antoranz González María Jesús

Subjects
Impedancia bioeléctrica, Antropometría, Tejido adiposo, Índice adiposo-muscular corporal, Composición corporal, Salud de las mujeres, Medicine, Public aspects of medicine, RA1-1270
Abstract

Fundamentos: La evaluación nutricional durante la premenopausia y la menopausia tiene un papel relevante para valorar los cambios que acontecen en la mujer. El objetivo de este estudio es comparar los parámetros grasa corporal e índice adiposo-muscular corporal (IAMC) estimados mediante impedanciometría respecto al índice de masa corporal (IMC) en la definición del estado nutricional y la composición corporal. Métodos: Estudio descriptivo transversal. Mediante muestreo aleatorio (base de tarjeta sanitaria) fueron seleccionadas 30 mujeres de 35 a 55 años, valorándose en ellas la asociación entre grasa corporal e IAMC con el IMC; diferentes estimadores de la distribución de la grasa corporal: circunferencias de la cintura y cresta ilíaca, cocientes cintura-cadera e ilíaca-cadera y diámetros ilíaco y sagital; presiones arteriales sistólica (PAS) y diastólica (PAD) y niveles plasmáticos de glucosa, colesterol, HDL-colesterol y triglicéridos. Resultados: El porcentaje de grasa corporal correlacionó intensamente (p

Published
2002

30. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial

Author

Borobia, Alberto M, primary, Carcas, Antonio J, additional, Pérez-Olmeda, Mayte, additional, Castaño, Luis, additional, Bertran, María Jesús, additional, García-Pérez, Javier, additional, Campins, Magdalena, additional, Portolés, Antonio, additional, González-Pérez, María, additional, García Morales, María Teresa, additional, Arana-Arri, Eunate, additional, Aldea, Marta, additional, Díez-Fuertes, Francisco, additional, Fuentes, Inmaculada, additional, Ascaso, Ana, additional, Lora, David, additional, Imaz-Ayo, Natale, additional, Barón-Mira, Lourdes E, additional, Agustí, Antonia, additional, Pérez-Ingidua, Carla, additional, Gómez de la Cámara, Agustín, additional, Arribas, José Ramón, additional, Ochando, Jordi, additional, Alcamí, José, additional, Belda-Iniesta, Cristóbal, additional, Frías, Jesús, additional, Martínez de Soto, Lucía, additional, Rodríguez Mariblanca, Amelia, additional, Díaz García, Lucía, additional, Ramírez García, Elena, additional, Seco Meseguer, Enrique, additional, Stewart Balbás, Stefan Mark, additional, Marín Candón, Alicia, additional, García García, Irene, additional, Urroz Elizalde, Mikel, additional, Monserrat Villatoro, Jaime, additional, de la Rosa, Paula, additional, Sanz García, Marta, additional, López Crespo, Cristina, additional, Mauleón Martínez, Vega, additional, de Madariaga Castell, Raquel, additional, Vitón Vara, Laura, additional, García Rodríguez, Julio, additional, Buño, Antonio, additional, López Granados, Eduardo, additional, Cámara, Carmen, additional, Rey Cuevas, Esther, additional, Ayllon García, Pilar, additional, Jiménez González, María, additional, Hernández Rubio, Victoria, additional, Moraga Alapont, Paloma, additional, Sánchez, Amparo, additional, Prieto, Rocío, additional, Llorente Gómez, Silvia, additional, Miragall Roig, Cristina, additional, Aparicio Marlasca, Marina, additional, de la Calle, Fernando, additional, Arsuaga, Marta, additional, Duque, Blanca, additional, Meijide, Susana, additional, García de Vicuña, Aitor, additional, Santorcuato, Ana, additional, Expósito, Iraide, additional, de Benito, Sara, additional, Andia, Joseba, additional, Castillo, Cristina, additional, Irurzun, Esther, additional, Camino, Jesús, additional, Temprano, Mikel, additional, Goikoetxea, Josune, additional, Bustinza, Alazne, additional, Larrea, Maialen, additional, Gallego, Mikel, additional, García-Vázquez, Dolores, additional, de la Hoz, Ana Belén, additional, Pérez-Nanclares, Gustavo, additional, Pérez-Guzmán, Estíbaliz, additional, Idoyaga, Eneko, additional, Lamela, Adriana, additional, Oteo, Jesús, additional, Castillo de la Osa, María, additional, Hernández Gutiérrez, Lourdes, additional, Andrés Galván, María Elena, additional, Calonge, Esther, additional, Bermejo, Mercedes, additional, de la Torre-Tarazona, Erick Humberto, additional, Cascajero, Almudena, additional, Fedele, Giovanni, additional, Perea, Concepción, additional, Cervera, Isabel, additional, Bodega-Mayor, Irene, additional, Montes-Casado, María, additional, Portolés, Pilar, additional, Baranda, Jana, additional, Granés, Laura, additional, Lazaar, Sulayman, additional, Herranz, Sara, additional, Mellado, María Eugènia, additional, Tortajada, Marta, additional, Malet, Montserrat, additional, Quesada, Sebastiana, additional, Vilella, Anna, additional, Llupià, Anna, additional, Olivé, Victoria, additional, Trilla, Antoni, additional, Gómez, Begoña, additional, González, Elisenda, additional, Romero, Sheila, additional, Gámez, Francisco Javier, additional, Casals, Cristina, additional, Burunat, Laura, additional, Castelló, Juan José, additional, Fernández, Patricia, additional, Bedini, Josep Lluís, additional, Vila, Jordi, additional, Aguilar, Carla, additional, Altadill, Carmen, additional, Armadans, Lluis, additional, Borras-Bermejo, Blanca, additional, Calonge, Julia, additional, Camacho, Lina, additional, Feliu, Anna, additional, Gili, Gisela, additional, Llorente, Cesar, additional, Martínez-Gómez, Xavier, additional, Otero-Romero, Susana, additional, Palacio, Esther, additional, Parés, Oleguer, additional, Pinós, Laia, additional, Plaza, Aitana, additional, Riera-Arnau, Judit, additional, Rodrigo-Pendás, José Angel, additional, Sans, Carla, additional, Santos, José, additional, Torres, Gloria, additional, Torrens, Margarita, additional, Uriona, Sonia, additional, Ballarin Alins, Elena, additional, Pérez Esquirol, Eulàlia, additional, Vendrell Bosch, Lourdes, additional, Laredo Velasco, Leonor, additional, Uribe López, Diana, additional, González Rojano, Esperanza, additional, Sánchez-Craviotto, Manuel, additional, Rivas Paterna, Ana Belén, additional, Hernán-Gómez, Teresa Iglesias, additional, Rodríguez Galán, Natalia, additional, Gil Marín, José Antonio, additional, Álvarez-Morales, Verónica, additional, Navalpotro, Ana Belén, additional, Jiménez-Santamaría, M Dolores, additional, Cardós, M Carmen, additional, Hermoso, Elena, additional, García-Arenillas, Mar, additional, Pérez Macías, Natalia, additional, Domingo Fernández, Alexandra, additional, López Picado, Amanda, additional, Quiñones, Jorge Mario, additional, Deidda, Nicoletta, additional, García-Franco, Ana, additional, and Torvisco, José María, additional

Published
2021
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31. Desarrollo de modelos predictivos de mortalidad y reingreso a corto plazo en pacientes ingresados por un primer episodio de insuficiencia cardíaca. Resultados del estudio multicéntrico PREDICE

Author

Guerra Vales, Juan Manuel, Gómez de la Cámara, Agustín Ramón, Torralba Morón, Ángel, Guerra Vales, Juan Manuel, Gómez de la Cámara, Agustín Ramón, and Torralba Morón, Ángel

Abstract

La insuficiencia cardíaca (IC) es un problema de salud pública de primer orden. Es una enfermedad frecuente que deteriora la calidad de vida de los pacientes que la padecen, condiciona una elevada morbimortalidad y supone un elevado gasto sanitario. Durante décadas, se han desarrollado trabajos de investigación diseñados para identificar aquellos factores que influyen en el pronóstico de la IC. En los últimos años, la investigación se ha orientado a tratar de elaborar modelos predictivos de riesgo de reingreso y mortalidad en pacientes afectos de IC. Estos modelos se elaboran a partir de la combinación de diferentes factores de mal pronóstico previamente identificados en los pacientes con IC. El objetivo de este trabajo es diseñar modelos predictivos de riesgo de reingreso y mortalidad durante el primer mes de seguimiento en pacientes ingresados específicamente por un primer episodio de IC..., Heart failure (HF) is a major public health problem. It is a frequent disease that deteriorates the quality of life of those patients who suffer from it. This disease conditions a high morbidity and mortality and implies a high health expenditure. For decades, they have been developed various research projects designed to identify those factors that influence the prognosis of HF. In recent years, research has focused on trying to develop predictive risk models of readmission and mortality in patients with HF. These models are developed from the combination of different poor prognostic factors previously identified in patients with HF. The objective of this work is to design predictive risk models of readmission and mortality during the first follow-up month in patients specifically admitted for a first episode of HF...

Published
2021

32. Two Dimensions of Nutritional Value: Nutri-Score and NOVA

Author

Romero Ferreiro, Carmen, Lora Pablos, David, Gómez de la Cámara, Agustín, Romero Ferreiro, Carmen, Lora Pablos, David, and Gómez de la Cámara, Agustín

Abstract

Front-of-pack labels can improve the ability of consumers to identify which foods are healthier, making them a useful public health tool. Nutri-Score is a front-of-pack labelling system adopted by several European countries. This system ranks foods according to their nutritional quality, but does not consider other dimensions such as the degree of food processing. The aim of this study is to compare the nutritional quality (as assessed by Nutri-Score) and the ultra-processing (as assessed by the NOVA classification) of foods in the Open Food Facts database. A simple correspondence analysis was carried out to study the relationship between the two systems. Ultra-processed foods (NOVA 4) were found in all Nutri-Score categories, ranging from 26.08% in nutritional category A, 51.48% in category B, 59.09% in category C, 67.39% in category D to up to 83.69% in nutritional category E. Given the negative effect that the consumption of ultra-processed foods has on different aspects of health, front-of-pack labelling with Nutri-Score should at least be accompanied by complementary labelling indicating the level of processing, such as the NOVA classification., hospital 12 de Octubre (i+12), Fac. de Ciencias Biológicas, Fac. de Estudios Estadísticos, Fac. de Medicina, TRUE, pub

Published
2021

35. Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease

Author

Di Angelantonio, Emanuele, Gao, Pei, Khan, Hassan, Butterworth, Adam S., Wormser, David, Kaptoge, Stephen, Kondapally Seshasai, Sreenivasa Rao, Thompson, Alex, Sarwar, Nadeem, Willeit, Peter, Ridker, Paul M, Barr, Elizabeth L. M., Khaw, Kay-Tee, Psaty, Bruce M., Brenner, Hermann, Balkau, Beverley, Dekker, Jacqueline M., Lawlor, Debbie A., Daimon, Makoto, Willeit, Johann, Njølstad, Inger, Nissinen, Aulikki, Brunner, Eric J., Kuller, Lewis H., Price, Jackie F., Sundström, Johan, Knuiman, Matthew W., Feskens, Edith J. M., Verschuren, W. M. M., Wald, Nicholas, Bakker, Stephan J. L., Whincup, Peter H., Ford, Ian, Goldbourt, Uri, Gómez-de-la-Cámara, Agustín, Gallacher, John, Simons, Leon A., Rosengren, Annika, Sutherland, Susan E., Björkelund, Cecilia, Blazer, Dan G., Wassertheil-Smoller, Sylvia, Onat, Altan, Marín Ibañez, Alejandro, Casiglia, Edoardo, Jukema, Wouter J., Simpson, Lara M., Giampaoli, Simona, Nordestgaard, Børge G., Selmer, Randi, Wennberg, Patrik, Kauhanen, Jussi, Salonen, Jukka T., Dankner, Rachel, Barrett-Connor, Elizabeth, Kavousi, Maryam, Gudnason, Vilmundur, Evans, Denis, Wallace, Robert B., Cushman, Mary, D’Agostino, Ralph B., Sr, Umans, Jason G., Kiyohara, Yutaka, Nakagawa, Hidaeki, Sato, Shinichi, Gillum, Richard F., Folsom, Aaron R., van der Schouw, Yvonne T., Moons, Karel G., Griffin, Simon J., Sattar, Naveed, Wareham, Nicholas J., Selvin, Elizabeth, Thompson, Simon G., and Danesh, John

Published
2014
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37. Ultra-processed food intake and all-cause mortality: DRECE cohort study.

Author

Romero Ferreiro, Carmen, Martín-Arriscado Arroba, Cristina, Cancelas Navia, Pilar, Lora Pablos, David, and Gómez de la Cámara, Agustín

Subjects
MORTALITY, FOOD consumption, COHORT analysis, PROCESSED foods, CARDIOVASCULAR diseases risk factors, FOOD industry
Abstract

Objective: To determine the association between ultra-processed food (UPF) intake and all-cause mortality in a representative sample of Spanish population. Design: Prospective cohort design in which follow-up lasted from baseline (1991) to mortality date or 31 December 2017, whichever was first. Dietary information was collected using a validated frequency questionnaire and categorised following the NOVA classification according to the extent of food processing. The association between consumption of UPF and mortality was analysed using Cox models. Isoenergetic substitution models were constructed to compare the health effects of the NOVA groups. Setting: Cohort from the Diet and Risk of Cardiovascular Diseases (CVD) in Spain (DRECE) study, representative of the Spanish population Participants: Totally, 4679 subjects between 5 and 59 years old. Results: Average consumption of UPF was 370·8 g/d (24·4 % of energy intake). After a median follow-up of 27 years, 450 deaths occurred. Those who consumed the highest amount of UPF had higher risk of mortality. For every 10 % of the energy intake from UPF consumption, an increase of 15 % in the hazard of all-cause mortality was observed (HR 1·15; (95 % CI 1·03, 1·27); P-value = 0·012). Substitution of UPF with minimally processed foods was significantly associated with a decreased risk of mortality. Conclusions: An increase in UPF consumption was associated with higher risk of all-cause mortality in a representative sample of the Spanish population. Moreover, the theoretical substitution of UPF with unprocessed or minimally processed foods leads to a decrease in mortality. These results support the need to promote diets based on unprocessed or minimally processed foods. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Reactogenicity and Immunogenicity of BNT162b2 in Subjects Having Received a First Dose of ChAdOx1s: Initial Results of a Randomised, Adaptive, Phase 2 Trial (CombiVacS)

Author

Borobia, Alberto M, primary, Carcas, Antonio J, additional, Pérez Olmeda, María Teresa, additional, Castaño, Luis, additional, Jesús Bertrán, María, additional, García-Pérez, Javier, additional, Campins, Magdalena, additional, Portolés, Antonio, additional, Gonzalez-Perez, Maria, additional, García Morales, María Teresa, additional, Arana, Eunate, additional, Aldea Novo, Marta, additional, Díez-Fuertes, Francisco, additional, Fuentes-Camps, Inmaculada, additional, Ascaso, Ana, additional, Lora, David, additional, Imaz-Ayo, Natale, additional, Baron-Mira, Lourdes E, additional, Agustí, Antonia, additional, Pérez-Ingidua, Carla, additional, Gómez de la Cámara, Agustín, additional, Arribas, JR, additional, Ochando, Jordi, additional, Alcamí Pertejo, José, additional, Belda-Iniesta, Cristóbal, additional, Frías, Jesús, additional, and Group, CombiVacS Study, additional

Published
2021
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41. Desarrollo de modelos predictivos de mortalidad y reingreso a corto plazo en pacientes ingresados por un primer episodio de insuficiencia cardíaca. Resultados del estudio multicéntrico PREDICE

Author

Torralba Morón, Ángel, Guerra Vales, Juan Manuel, Gómez de la Cámara, Agustín Ramón, Torralba Morón, Ángel, Guerra Vales, Juan Manuel, and Gómez de la Cámara, Agustín Ramón

Abstract

La insuficiencia cardíaca (IC) es un problema de salud pública de primer orden. Es una enfermedad frecuente que deteriora la calidad de vida de los pacientes que la padecen, condiciona una elevada morbimortalidad y supone un elevado gasto sanitario. Durante décadas, se han desarrollado trabajos de investigación diseñados para identificar aquellos factores que influyen en el pronóstico de la IC. En los últimos años, la investigación se ha orientado a tratar de elaborar modelos predictivos de riesgo de reingreso y mortalidad en pacientes afectos de IC. Estos modelos se elaboran a partir de la combinación de diferentes factores de mal pronóstico previamente identificados en los pacientes con IC. El objetivo de este trabajo es diseñar modelos predictivos de riesgo de reingreso y mortalidad durante el primer mes de seguimiento en pacientes ingresados específicamente por un primer episodio de IC...

Published
2020

42. Determinación de la influencia del consumo de vitaminas en el desarrollo de diabetes. Estudio DRECE

Author

García García, María Nieves, Gómez de la Cámara, Agustín, Martí Centeno, Lluc-Jordi, García García, María Nieves, Gómez de la Cámara, Agustín, and Martí Centeno, Lluc-Jordi

Abstract

La diabetes mellitus es una de las enfermedades que afecta a más personas en el mundo y una de las cuáles no tiene cura aún. Se ha relacionado a esta enfermedad con diversos factores que pueden prevenir su desarrollo o retrasarlo con unos síntomas más leves como lo pueden ser la edad o el sexo. En el estudio realizado a partir de los datos del estudio DRECE, se quiere demostrar el papel que tiene el consumo de vitaminas, tanto hidrosolubles como la D, como liposolubles como la E y la A, de tal manera en que se evite o retrase la aparición de esta patología.

Published
2020

46. The prognosis of patients hospitalized with a first episode of heart failure, validation of two scores: PREDICE and AHEAD

Author

Ruiz Ruiz, Francisco, Menéndez Orenga, Miguel, Medrano Ortega, Francisco Javier, Calderón Sandubete, Enrique José, Lora Pablos, David, Navarro Puerto, María Asunción, Gómez de la Cámara, Agustín, and Universidad de Sevilla. Departamento de Medicina.

Subjects
Inpatients, Severity of illness index, Heart failure, Validation studies as topics
Abstract

Purpose: Heart failure (HF) is a chronic, frequent and disabling condition but with a modifiable course and a large potential for improving. The aim of this study was to validate the two available clinical prediction rules for mortality at one year in patients with primo- hospitalization for decompensated HF: PREDICE and AHEAD. The secondary aim was to evaluate in our setting the changes in the clinical pattern of HF in the last decade in patients hospitalized for a first episode of the disease. Patients and methods: A prospective multicenter cohort study, which included 180 patients hospitalized with “de novo” HF was conducted to validate the PREDICE score. Calibration and discrimination measurements were calculated for the PREDICE model and the PREDICE score (using the validation cohort of the PREDICE) and the AHEAD score (using both the development and the validation cohort of the PREDICE). Results: For the PREDICE models, the area under the curve (AUC) was 0.68 (95% confidence interval [CI]: 0.57–0.79) and the calibration slope 0.65 (95% CI: 0.21–1.20). For the PREDICE score AUC was 0.59 (95% CI: 0.47–0.71) and slope 0.42 (95% CI: −0.20–1.17). For the AHEAD score the AUC was 0.68 (95% CI: 0.62–0.73) and slope 1.38 (95% CI: 0.62–0.73) when used the development cohort of PREDICE and the AUC was 0.58 (95% CI: 0.49–0.67), and slope 0.68 (95% CI: −0.06 to 1.47) when used its validation cohort. Conclusion: The present study shows that the two risk scores available for patients with primo-hospitalization for decompensated HF (PREDICE and AHEAD) are not currently valid for predicting mortality at one-year. In our setting the clinical spectrum of hospitalized patients with new-onset HF has been modified over time. The study underscores the need to validate the prognostic models before clinical implementation. Ministerio de Sanidad PI070945.

Published
2019

49. The prognosis of patients hospitalized with a first episode of heart failure, validation of two scores: PREDICE and AHEAD.

Author

Universidad de Sevilla. Departamento de Medicina., Ruiz Ruiz, Francisco, Menéndez Orenga, Miguel, Medrano Ortega, Francisco Javier, Calderón Sandubete, Enrique José, Lora Pablos, David, Navarro Puerto, María Asunción, Gómez de la Cámara, Agustín, Universidad de Sevilla. Departamento de Medicina., Ruiz Ruiz, Francisco, Menéndez Orenga, Miguel, Medrano Ortega, Francisco Javier, Calderón Sandubete, Enrique José, Lora Pablos, David, Navarro Puerto, María Asunción, and Gómez de la Cámara, Agustín

Abstract

Purpose: Heart failure (HF) is a chronic, frequent and disabling condition but with a modifiable course and a large potential for improving. The aim of this study was to validate the two available clinical prediction rules for mortality at one year in patients with primo- hospitalization for decompensated HF: PREDICE and AHEAD. The secondary aim was to evaluate in our setting the changes in the clinical pattern of HF in the last decade in patients hospitalized for a first episode of the disease. Patients and methods: A prospective multicenter cohort study, which included 180 patients hospitalized with “de novo” HF was conducted to validate the PREDICE score. Calibration and discrimination measurements were calculated for the PREDICE model and the PREDICE score (using the validation cohort of the PREDICE) and the AHEAD score (using both the development and the validation cohort of the PREDICE). Results: For the PREDICE models, the area under the curve (AUC) was 0.68 (95% confidence interval [CI]: 0.57–0.79) and the calibration slope 0.65 (95% CI: 0.21–1.20). For the PREDICE score AUC was 0.59 (95% CI: 0.47–0.71) and slope 0.42 (95% CI: −0.20–1.17). For the AHEAD score the AUC was 0.68 (95% CI: 0.62–0.73) and slope 1.38 (95% CI: 0.62–0.73) when used the development cohort of PREDICE and the AUC was 0.58 (95% CI: 0.49–0.67), and slope 0.68 (95% CI: −0.06 to 1.47) when used its validation cohort. Conclusion: The present study shows that the two risk scores available for patients with primo-hospitalization for decompensated HF (PREDICE and AHEAD) are not currently valid for predicting mortality at one-year. In our setting the clinical spectrum of hospitalized patients with new-onset HF has been modified over time. The study underscores the need to validate the prognostic models before clinical implementation.

Published
2019

50. The prognosis of patients hospitalized with a first episode of heart failure, validation of two scores: PREDICE and AHEAD

Author

Ministerio de Sanidad, Consumo y Bienestar Social (España), Menéndez-Orenga, Miguel [https://orcid.org/0000-0003-1315-4327], Medrano, Francisco Javier [https://orcid.org/0000-0001-5863-344X], Calderón, Enrique J. [https://orcid.org/0000-0002-3166-5086], Lora-Pablos, David [https://orcid.org/0000-0002-3317-5689], Ruiz-Ruiz, Francisco, Menéndez-Orenga, Miguel, Medrano, Francisco Javier, Calderón, Enrique J., Lora-Pablos, David, Navarro Puerto, María Asunción, Rodríguez-Torres, Patricia, Gómez de la Cámara, Agustín, Ministerio de Sanidad, Consumo y Bienestar Social (España), Menéndez-Orenga, Miguel [https://orcid.org/0000-0003-1315-4327], Medrano, Francisco Javier [https://orcid.org/0000-0001-5863-344X], Calderón, Enrique J. [https://orcid.org/0000-0002-3166-5086], Lora-Pablos, David [https://orcid.org/0000-0002-3317-5689], Ruiz-Ruiz, Francisco, Menéndez-Orenga, Miguel, Medrano, Francisco Javier, Calderón, Enrique J., Lora-Pablos, David, Navarro Puerto, María Asunción, Rodríguez-Torres, Patricia, and Gómez de la Cámara, Agustín

Abstract

[Purpose] Heart failure (HF) is a chronic, frequent and disabling condition but with a modifiable course and a large potential for improving. The aim of this study was to validate the two available clinical prediction rules for mortality at one year in patients with primo-hospitalization for decompensated HF: PREDICE and AHEAD. The secondary aim was to evaluate in our setting the changes in the clinical pattern of HF in the last decade in patients hospitalized for a first episode of the disease., [Patients and methods] A prospective multicenter cohort study, which included 180 patients hospitalized with “de novo” HF was conducted to validate the PREDICE score. Calibration and discrimination measurements were calculated for the PREDICE model and the PREDICE score (using the validation cohort of the PREDICE) and the AHEAD score (using both the development and the validation cohort of the PREDICE)., [Results] For the PREDICE models, the area under the curve (AUC) was 0.68 (95% confidence interval [CI]: 0.57–0.79) and the calibration slope 0.65 (95% CI: 0.21–1.20). For the PREDICE score AUC was 0.59 (95% CI: 0.47–0.71) and slope 0.42 (95% CI: −0.20–1.17). For the AHEAD score the AUC was 0.68 (95% CI: 0.62–0.73) and slope 1.38 (95% CI: 0.62–0.73) when used the development cohort of PREDICE and the AUC was 0.58 (95% CI: 0.49–0.67), and slope 0.68 (95% CI: −0.06 to 1.47) when used its validation cohort., [Conclusion] The present study shows that the two risk scores available for patients with primo-hospitalization for decompensated HF (PREDICE and AHEAD) are not currently valid for predicting mortality at one-year. In our setting the clinical spectrum of hospitalized patients with new-onset HF has been modified over time. The study underscores the need to validate the prognostic models before clinical implementation.

Published
2019

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