173 results on '"Gökçe S"'
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2. Kinetic parameters and luminescence properties of rare earth (Tb, Nd) doped and transition metal (Mn) doped/co-doped YAlO3 prepared via sol-gel method
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Gökçe, S., Keskin, İ.Ç., Katı, M.İ., Kibar, R., Çetin, A., and Tuncer Arslanlar, Y.
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- 2023
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Catalog
3. Luminescence characteristics and kinetic parameters of LiBaPO4: Tb3+, Dy3+ phosphors synthesized by sol-gel method
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Katı, M.İ., primary, Gökçe, S., additional, Keskin, İ.Ç., additional, Türemiş, M., additional, Çetin, A., additional, and Kibar, R., additional
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- 2023
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4. MnCrxFe2−xO4 Nanoparticles: Magnetic and Microwave Absorption Properties
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Baykal, A., Genç, F., Elmal, A. Z., Gökçe, S., Sertkol, M., and Sözeri, H.
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- 2016
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5. Chapter4.20 - Vanillin
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Karatoprak, Gökçe Ş.
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- 2022
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6. Storing and managing water for the environment is more efficient than mimicking natural flows
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Sarah E. Null, Harrison Zeff, Jeffrey Mount, Brian Gray, Anna M. Sturrock, Gokce Sencan, Kristen Dybala, and Barton Thompson
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Science - Abstract
Abstract Dams and reservoirs are often needed to provide environmental water and maintain suitable water temperatures for downstream ecosystems. Here, we evaluate if water allocated to the environment, with storage to manage it, might allow environmental water to more reliably meet ecosystem objectives than a proportion of natural flow. We use a priority-based water balance operations model and a reservoir temperature model to evaluate 1) pass-through of a portion of reservoir inflow versus 2) allocating a portion of storage capacity and inflow for downstream flow and stream temperature objectives. We compare trade-offs to other senior and junior priority water demands. In many months, pass-through flows exceed the volumes needed to meet environmental demands. Storage provides the ability to manage release timing to use water efficiently for environmental benefit, with a co-benefit of increasing reservoir storage to protect cold-water at depth in the reservoir. more...
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- 2024
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7. Why Do Some Depressive Patients Have Suicidal Ideation but Others Not? Suicidal Ideation From the Perspective of Affective Neuroscience Personality Traits
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Yasemin Hoşgören Alici, Selvi Ceran, Jamal Hasanli, Gonca Asut, Beren Özel, Zehra Ucar Hasanli, Gökçe Saygi, Arda Bağcaz, and Emre Misir
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affective neuroscience ,hopelessness ,major depressive disorder ,suicide ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
ABSTRACT Introduction Although major depression is the disorder most frequently associated with suicidal behavior, it is unclear that major depressive disorder patients may develop suicidal ideation. Basic affective system theory may provide a novel and beneficial viewpoint in this field. The goal of this study was to investigate the basic affective system in relation to suicidal ideation in individuals with depression. Method The study population comprised 160 participants who had been formally diagnosed with major depressive disorder. Participants were divided into two groups according to whether they had suicide ideation (depression with suicide [DS]) (N = 93) or not (depression with no suicidal ideation [DNS]) (N = 67). The Beck Depression Inventory (BDI), the Suicide Probability Scale (SPS), the Beck Hopelessness Scale (BHS), and the Affective Neuroscience Personality Scale (ANPS) were applied. Statistical Product and Service Solutions (SPSS) 24 and the SPSS macroprocess, which were specifically developed for assessing complex models including serial mediators, were used to analyze the data. Results The mean age of all participants was 31.1 ± 11 years, and most of them were female (65%). The DS group had a higher family history of psychiatric medication use and suicidal attempts. In addition, BDI, BHS, and SPS total scores were higher, as well as ANGER subscale scores were higher in the DS group. In mediation analysis, the ANGER subscale significantly predicted the presence of suicide ideation. We observed a direct effect of the ANGER subscale score on suicide ideation as well as an indirect effect of the ANGER subscale score on suicidal ideation via depression severity. Conclusion Higher scores on ANGER are associated with suicidal ideation. Neurobiological correlates, including the ANGER system, may be promising in understanding suicidal behaviors. more...
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- 2024
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8. A comprehensive review on the potential of coumarin and related derivatives as multi-target therapeutic agents in the management of gynecological cancers
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Gökçe Şeker Karatoprak, Berrak Dumlupınar, Engin Celep, Inci Kurt Celep, Esra Küpeli Akkol, and Eduardo Sobarzo-Sánchez
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coumarin ,drug discovery ,gynecological cancer ,natural compound ,structure–activity relationships of coumarins ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Current treatments for gynecological cancers include surgery, radiotherapy, and chemotherapy. However, these treatments often have significant side effects. Phytochemicals, natural compounds derived from plants, offer promising anticancer properties. Coumarins, a class of benzopyrone compounds found in various plants like tonka beans, exhibit notable antitumor effects. These compounds induce cell apoptosis, target PI3K/Akt/mTOR signaling pathways, inhibit carbonic anhydrase, and disrupt microtubules. Additionally, they inhibit tumor multidrug resistance and angiogenesis and regulate reactive oxygen species. Specific coumarin derivatives, such as auraptene, praeruptorin, osthole, and scopoletin, show anti-invasive, anti-migratory, and antiproliferative activities by arresting the cell cycle and inducing apoptosis. They also inhibit metalloproteinases-2 and -9, reducing tumor cell migration, invasion, and metastasis. These compounds can sensitize tumor cells to radiotherapy and chemotherapy. Synthetic coumarin derivatives also demonstrate potent antitumor and anticancer activities with minimal side effects. Given their diverse mechanisms of action and minimal side effects, coumarin-class phytochemicals hold significant potential as therapeutic agents in gynecological cancers, potentially improving treatment outcomes and reducing side effects. This review will aid in the synthesis and development of novel coumarin-based drugs for these cancers. more...
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- 2024
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9. Determination of Factors Affecting Sleep Quality in Postoperative Patients and Improvement of Correctible Causes
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Ayşegül Özgök, Gökçe Selçuk Sert, and Dilek Öztürk Kazancı
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uyku kalitesi ,pittsburg uyku kalitesi indeksi ,postoperatif uyku kalitesi ,sleep quality ,pittsburg sleep quality index ,postoperative sleep quality ,Medicine (General) ,R5-920 - Abstract
Patients who had postoperative major abdominal surgery and major cardiovascular surgery were included in our study. A total of 103 patients were included in the study. Patients were evaluated with the Pitssburg sleep quality index questionnaire between five and seven days postoperatively. All questionnaires and scales were administered by the same researcher without specifying the participant's name in order to maintain consistency. After explaining the scope and purpose of the study, written consent of all participants was obtained. Pittsburg sleep quality index is a 19-item self-report scale that evaluates sleep quality and disorder. It consists of 24 questions, 19 questions are self-report questions, 5 questions are questions to be answered by the spouse or roommate. The 18 scored questions of the scale consist of 7 components. Subjective Sleep Quality, Sleep Latency, Sleep Duration, Habitual Sleep Efficiency, Sleep Disorder, Sleeping Drug Use, and Daytime Dysfunction. Each component is evaluated over 0-3 points. The total score of the 7 components gives the scale total score. The total score ranges from 0 to 21. A total score greater than 5 indicates "poor sleep quality". In our study, we aimed to investigate whether anesthetic agents, concomitant diseases, type of surgery, and some biochemical parameters affect sleep quality in postoperative patients. The diseases we investigated included hypertension, chronic obstructive pulmonary diseases, asthma, heart failure, cerebrovascular diseases, thyroid function disorders, diabetes mellitus, chronic kidney diseases, and chronic kidney failure. We also evaluated the sociocultural levels of the patients as an important part of the study. Educational status of our patients, literacy rates and occupations were also important to us. In our study, we showed that anesthetic agents [hypnotic and opioid] had no effect on sleep quality, and sleep quality was worse in cardiovascular surgery cases, although it was not statistically significant. We showed that a long operation time (5 hours and more) impairs postoperative sleep quality, thyroid diseases affect sleep quality badly, and sleep disorders are more common especially in patients with COPD. We think that sleep has a very important place in accelerating the recovery process of postoperative patients and that sleep disorders should be questioned better and that postoperative patients with sleep disorders should definitely seek psychological and medical help. more...
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- 2024
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10. Medication overuse headache: a 12-year follow-up study of 77 patients: EP1233
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Beckmann, Y., Gökçe, S., and İnceoğlu, A.
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- 2014
11. bis(N,N-diethylnicotinamide) p-chlorobenzoate complexes of Ni(II), Zn(II) and Cd(II): Synthesis and characterization
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Köse, D. A., Gökçe, G., Gökçe, S., and Uzun, İ.
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- 2009
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12. PİYASADAN TEMİN EDİLEN BAZI YAĞLARIN ANTİOKSİDAN AKTİVİTESİNİN ÇEŞİTLİ YÖNTEMLERLE DEĞERLENDİRİLMESİ
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Kübra Karagül, Gökçe Şeker Karatoprak, Selen İlgün, and Semih Yıldırım
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sabit yağ ,antioksidan ,abts ,dpph ,lipit peroksidasyon ,fixed oil ,antioxidant ,lipid prexidation ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Science ,Science (General) ,Q1-390 - Abstract
Sabit yağlar ve uçucu yağlar, yüzyıllardır insanlar tarafından, hastalıkların tedavi edilmesinde, hastalıklardan korunmak amacıyla ve yaşam kalitesini artırmak için kullanılmaktadır. Ayrıca çoğu bitkisel kökenli olan, özellikle bitkilerin yağlı tohumlarından elde edilen yağlar, aromaterapide “taşıyıcı yağ” olarak kullanılmaktadır. Tedavide kullanılan bu yağların yapısı, kalitesi, elde ediliş şekli ve tedaviye uygun olarak seçilmesi, yağın tedaviye olumlu katkı vermesini sağlayan en önemli etmendir. Özellikle yaşlanma karşıtı ürünlerde tercih edilen yağlar antioksidan özellikleri ile ön plana çıkmakta ve bu yönüyle tedaviye destek olmaktadırlar. Çalışmada da bu amaca yönelik olarak piyasada bulunan bazı yağların antioksidan aktivitesi karşılaştırılmıştır. Yöntem olarak 1,1-difenil-2-pikrilhidrazil (DPPH•) radikal süpürücü etki, 2,2’- azino-bis (3-etilbenzotiazolin-6- sulfonik asit) (ABTS+•) radikal süpürücü etki ve askorbat–Fe (III)-katalizli fosfolipit peroksidasyonunu engelleyici etki tayini yöntemleri kullanılmıştır. Deneysel çalışmalarda kullanılan buğday rüşeymi (Triticum sativum), keten tohumu (Linum usitatissimum), nar çekirdeği (Punica granatum), kişniş (Coriandrium sativum), çörek otu (Nigella sativa), sakız kabağı tohumu yağları (Cucurbita sp.) ve zerdeçal ekstresi (Curcuma longa) piyasadan temin edilmiştir. Yapılan çalışmalar sonucunda zerdeçal ekstresi ve buğday rüşeym yağı en aktif yağlar olarak belirlenmişlerdir. more...
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- 2024
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13. Innovation for Economic Growth: G7 vs E7
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Ayşegül Gürsoy and Gökçe Sinem Erbuğa
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innovation ,global innovation index ,g7 ,e7 ,inovasyon ,küresel i̇novasyon endeksi ,Industrial productivity ,HD56-57.5 - Abstract
Purpose: The main objective of this research is to examine the impact of R&D expenditures and Global Innovation Index ranking on per capita income in E7 and G7 country groups. Methodology: Logistic regression model was used as the research method in the study. Stata 18 Data Analysis and Statistical Software Program was used in the analysis of the data. At the hand of Stata 18 Data Analysis and Statistical Software Program, regression analysis was used to estimate the possible and unknown effects of independent variables on the dependent variable. During the collection of the data used in the study, the archive scanning method, which is one of the qualitative research methods, was used. Archival reports and official records were also used in the study. Findings: According to the research results, 83.56% of the model is explained by explanatory variables. With all other explanatory variables constant, a 1% increase in R&D expenditure will result in an increase of 0.5243% on GDP per capita. At the same time, this coefficient gives the flexibility of GDP per capita relative to R&D expenditure (%GDP). It is also found out that there is a positive relationship between GDP per capita and R&D expenditure and also, there is a negative relationship between GDP per capita-GII ranking. In this study, which deals with the innovation efficiency of the G7 countries and the E7 countries, and the effect of this performance on the GDP per capita, it is seen that the G7 countries spend more on innovation. Originality: It contributes to the literature as there is no other study in the literature that deals with per capita income, Global Innovation Index ranking and R&D expenditures comparatively between the G7 and E7. more...
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- 2024
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14. Periocular involvement in cutaneous leishmaniasis
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Durdu, M, Gökçe, S, Bagirova, M, Yalaz, M, Allahverdiyev, A M, and Uzun, S
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- 2007
15. Atrioventricular Septal Defects Repair: Comparison of Classic Single Patch and Double-Patch Techniques
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Kanat Özışık, Gökçe Selçuk Sert, Yasemin Özdemir Şahan, Ahmet Vedat Kavurt, Mustafa Yılmaz, Ata Niyazi Ecevit, Başak Soran Türkcan, and Atakan Atalay
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atrioventriküler septal defekt ,pulmoner hipertansiyon ,farklı tamir yöntemleri ,endokardiyal yastıkçık defektleri. ,atrioventricular septal defect repair ,pulmonary hypertension ,different techniques for repair ,endocardial cushion defects. ,Medicine (General) ,R5-920 - Abstract
Objective: Different patch techniques were virtually always used in the surgery of pediatric patients with complete atrioventricular septal defects. In this study, we described our single center, single surgeon experiences and results about the classic single patch and double patch techniques to repair complete atrioventricular septal defects. Materials and Methods: This retrospective descriptive study included 30 patients who underwent intracardiac repair of complete atrioventricular septal defect in Ankara Bilkent City Hospital Department of Pediatric Cardiovascular Surgery. The study was conducted between February 2019 to December 2021. Patients in group S underwent surgery using the traditional single-patch method, while group D included patients who underwent repair using the double patch approach (n = 10). Patients’ demographic and clinical information was taken from institutional databases and medical records. Postoperative complications were recorded. Results: When the preoperative/postoperative insufficiency levels of the valves were compared with the Wilcoxon Signed rank test, the findings were not statistically significant for the left atrioventricular valves, but were statistically significant for the right atrioventricular valves. (p=0.02) When we compared postoperative valve regurgitation of both techniques with the Kruskall-Wallis test, no significant difference was found between postoperative valve regurgitation and function, independent of preoperative findings. Conclusion: Both operation techniques did not make a difference between operative or late mortality and morbidity. Depending on the surgeon’s experience, ventricular septal defect size does not play a restrictive role in the selection of the technique to be used. The single-patch and double patch method as described here is methodical, comprehensible, repeatable, and reasonably long-lasting. more...
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- 2023
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16. A green HPLC method for the determination of apixaban in pharmaceutical products: Development and validation
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Akbel Erten, Bulduk İbrahim, and Gökçe Süleyman
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green separation ,pharmaceutical analysis ,apixaban ,Chemistry ,QD1-999 - Published
- 2023
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17. Contributors
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Abdolghaffari, Amir Hossein, Adhikari-Devkota, Anjana, Ahmed, Salman, Alhasani, Reem Hasaballah, Alqarni, Mohammed, Althobaiti, Norah A., Alves, Renata de Sousa, Arya, Rajeshwar K.K., Asghari, Mohammad Hossein, Azeemah, Chundoo B., Azzopardi, Joseph I., Baureek, Nawshin, Behl, Tapan, Belwal, Tarun, Benmelouka, Amira Y., Bhandari, Dhaka R., Bisht, Dheeraj, Bisht, Arti, Blundell, Renald, Blázovics, Anna, Bouhenni, Hasna, Braga, Jacqueline Ramos Machado, Chafaa, Meriem, Chatterjee, Sharmistha, Chauhdary, Zunera, Chen, Xiuping, Chen, Lei, Coy-Barrera, Ericsson, Das, Abhishek K., Devkota, Hari P., Dey, Prasanta, Dhariwal, Arasana, Dilmar A., Sanaa, Doukani, Koula, Durgapal, Sumit, Désiré A.-L., Daphne, Ezzat, Shahira M., Fakhri, Sajad, Farzaei, Mohammad Hosein, Fatimah-Tuz-Zohra, Joomun B., Garg, Aakriti, Ghosh, Noyel, Ghosh, Sumit, Gour, Jalaj K., Gurgel, Daniel Cordeiro, Hassani, Shokoufeh, Hossain, Uday, Hussein, Subratty A., Iqbal, Shabnoor, Jantwal, Arvind, Jorge, Roberta Jeane Bezerra, Joshi, Tanuj, Juyal, Vijay, Kaldate, Rahul, Karatoprak, Gökçe Ş., Karmakar, Arnab, Khadaroo, S. Khatoon, Khan, Haroon, Khan, Abdul H., Khan, Ziyad, Kumar, Anoop, Kumar, Prashant, Kumar, Aadesh, Kumar, Manish, Kumar, Ankit, Laxmi, Jankee T., Lobine, Devina, M. Irfaan, Meeajan, Maggi, Filippo, Mahdy, Nihal M. El, Mahfouz, Marwa M., Mahomoodally, Mohamad Fawzi, Mandal, Ankita, Marinho, Aline Diogo, Maurya, Harikesh, Miao, Lingchao, Moloudizargari, Milad, Momtaz, Saeideh, Mujtaba Shah, Ghulam, Nabavi, Seyed Mohammad, Nabee, Nouzaifa, Nogueira-Junior, Francisco Assis, Nunes-Pinheiro, Diana Célia Sousa, Pandey, Abhay K., Patni, Kiran, Patni, Pooja, Patni, Lokesh, Pratap, Vinay, Rajpal, Govind, Ramos, Márcia Maria Vieira, Rana, Harvesh Kumar, Rana, Mahendra, Rana, Amita J., Rasool, Shahid, Rasul, Azhar, Rasul, Akhtar, Rosette M. A.-L., Elodie, Sah, Archana N., Salem, Mohamed A., Sarkar, Kasturi, Selles, Ammar S.M., Shah, Muhammad Ajmal, Shah, Ghulam Mujtaba, Shah, Shahid, Sharma, Ruchika, Sil, Parames C., Silva, Ana Sanches, Silveira, João Alison de Moraes, Singh, Amit Kumar, Singh, Anita, Singh, Manoj K., Singh, Sushil Kumar, Singh, Laxman, Soudani, Leila, Süntar, Ipek, Tewari, Devesh, Tiwari, Nidhi, Ullah, Malik Saad, Ullah, Hammad, Upadhyay, Jyoti, Vasconcelos, Mirele da Silveira, Visvarma, Sandeep, Xiao, Jianbo, Xie, Yixi, Yakıncı, Ömer F., Yang, Li, Zaynab, Toorabally B., Zhang, Haolin, da Silva Mendes, Francisco Rogênio, de Melo, Dirce Fernandes, de Paula, Paulo Carvalho, de Siqueira Oliveira, Luciana, de Sousa, Felipe Domingos, de Souza, Tamiris de Fátima Goebel, and Álvarez-Caballero, Juan M. more...
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- 2022
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18. Genotype-Phenotype Correlations in Pompe Disease
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Herzog, A., Hartung, R., Mengel, E., Hermanns, P., Runz, H., Gökce, S., Pohlenz, J., and Beck, M.
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- 2011
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19. Upscaling the Production of High Temperature Polymer Electrolyte Membrane Fuel Cells – an Assessment of Reproducibility, Performance and Durability
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Bodner, Merit, primary, García, Héctor R., additional, Steenberg, Thomas, additional, Vassiliev, Anton, additional, Alfaro, Silvia M., additional, Avcioglu, Gökçe S., additional, and Hjuler, Hans Aage, additional more...
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- 2018
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20. Unveiling the Antioxidant, Cytotoxic, and Anti-Inflammatory Activities and Chemical Compositional Information of an Invasive Plant: Lycium ferocissimum Miers
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Müberra Koşar, Gökçe Şeker Karatoprak, Beste Atlı, Selen İlgün, Esra Köngül Şafak, Nesrin Öztinen, Sena Akçakaya Mutlu, and Ezgi Ak Sakallı
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Lycium ferocissimum ,antioxidant ,anti-inflammatory ,cytotoxicity ,chromatography ,Botany ,QK1-989 - Abstract
In this study, the antioxidant (DPPH and ABTS radical-scavenging, ferric-reducing, iron (II)-chelating), anti-inflammatory (LPS-induced Raw 264.7 cell line), and cytotoxic activities (Du145 and A549 cell lines) of raw fruit, ripe fruit and leaves of the Lycium ferocissimum species were examined. By using high-pressure liquid chromatography, p-OH benzoic acid, caffeic acid, and rutin were detected in the ethanol and water extracts. For the most active raw fruit ethanol extract, the IC50 in terms of the DPPH-scavenging activity was 0.57 mg/mL, and the ABTS inhibition percentage was 88.73% at a 3 mg/mL concentration. The raw fruit ethanol extract exhibited significant inhibition of viability in the Du145 cell line in the concentration range of 62.5–1000 µg/mL. Additionally, the extract effectively reduced the LPS-induced inflammation parameters (TNF-α, IFN-γ, PGE 2, and NO) at a concentration of 31.25 µg/mL. The biological activities of L. ferocissimum, which have been elucidated for the first time, have yielded promising results. more...
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- 2024
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21. Medication overuse headache: Investigtion of integrity and volume of the white matter
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Beckmann, Y., primary, Gökçe, S., additional, Zorlu, N., additional, Türe, S., additional, and Gelal, F., additional
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- 2017
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22. Medication overuse headache: Investigtion of integrity and volume of the grey matter
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Beckmann, Y., primary, Gökçe, S., additional, Zorlu, N., additional, Türe, S., additional, and Gelal, F., additional
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- 2017
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23. A new system for nursing specialisation: the thoughts and opinions of nurses
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Adibelli, Derya, primary, Turan, Gökçe S, additional, and Çınar, Halise, additional
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- 2017
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24. Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects
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Çiğdem Yücel, Gökçe Şeker Karatoprak, Sena Yalçıntaş, and Tuğba Eren Böncü
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antioxidant effect ,antiaging effect ,epigallocatechin gallate ,ethosomal gel ,ethosome ,Technology ,Chemical technology ,TP1-1185 ,Science ,Physics ,QC1-999 - Abstract
Controlled release systems containing natural compounds have been successfully applied in cosmetics as antiaging products to enhance the penetration of active compounds through the skin. In this study, we aimed to develop novel ethosomal formulations containing a potent antioxidant, epigallocatechin-3-gallate (EGCG), and to evaluate their potential for use in cosmetics by determining their antioxidant and antiaging effects. Ethosomes (ETHs) were prepared via mechanical dispersion and characterized in vitro in terms of particle size (PS), zeta potential (ZP), polydispersity index (PDI), encapsulation efficiency percentage (EE%), and in vitro release. The best ETH formulation was used to prepare the ethosome-based gel (ETHG) by using Carbopol 980 as a gelling agent at a ratio of 1:1 (v/v). The gel formulation was evaluated regarding organoleptic properties, pH values, and viscosity. Stability studies were conducted for three months and changes in characterization parameters and residual EGCG content of ETHs were examined. Besides, for ETHG, organoleptic properties, pH values (every two weeks), and viscosity (first and twelfth week) were determined for three months. The 3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to test the cytotoxicity of the formulations and different EGCG solutions on the L929 cell line. The cell permeation properties and inhibitory effects of ETHs and ETHGs on collagenase and elastase enzymes were investigated compared to those of the solution form. Within the scope of antioxidant activity studies, 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+•) radical scavenging and β-carotene/linoleic acid co-oxidation inhibitory effects were carried out. The optimized EGCG-loaded ETHs (F3) were within the nanoscale range (238 ± 1.10 nm). The highest encapsulation efficiency and in vitro release values were 51.7 ± 1.15% and 50.8 ± 1.70%, respectively. The ETHG was successfully formulated with F3-coded ETHs and the cytotoxicity test revealed that the formulations and the EGCG solution at different concentrations were nontoxic. In terms of cell permeability, enzyme inhibition, and antioxidant activity, the ethosomal formulations yielded better results compared to the EGCG solution. It was observed that the formulations had a long-term effect due to the stability of EGCG. The findings of the study underline the potential of antioxidant and antiaging effects of the developed ethosomal formulations for use in the cosmetic field. more...
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- 2022
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25. Assessment of Phenolic Composition, Antioxidant Potential, Antimicrobial Properties, and Antidiabetic Activity in Extracts Obtained from Schinus molle L. Leaves and Fruits
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Selen İlgün, Gökçe Şeker Karatoprak, Derya Çiçek Polat, Esra Köngül Şafak, Çiğdem Yücel, Ufuk İnce, Hatice Özlem Uvat, and Esra Küpeli Akkol
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schinus molle ,anacardiaceae ,β-tc cells ,biological activity ,Biochemistry ,QD415-436 ,Biology (General) ,QH301-705.5 - Abstract
Background: The current research centers on exploring the antioxidant, antimicrobial, and antidiabetic features of Schinus molle L. grown in Turkey. Methods: Quantitative analysis of chlorogenic acid, caffeic acid, and hyperoside levels in leaf, ripe fruit, and raw fruit extracts was conducted using High-Performance Liquid Chromatography (HPLC) in a 70% methanol-water mixture. Among the extracts, the methanol extract from ripe fruits displayed the highest chlorogenic acid concentration, measuring at 2.040% ± 0.172% standard deviation (SD). Moreover, analysis of their total phenolic and flavonoid contents was carried out. Antioxidant power was assessed through different chemical assays, together with their antimicrobial and anti-diabetic properties. Results: The results of DPPH (2,2-Diphenyl-1-picrylhydrazyl), ABTS (2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and reducing power assays showed that leaf and ripe fruit alcoholic extract exhibited peak performance. While the MIC ( minimum inhibitory concentration) values of the extracts were determined to have moderate bactericidal effects on Staphylococcus aureus, Escherichia coli, and Candida albicans it was observed that none of the extracts displayed biofilm inhibition. The inhibition percentage of α-glucosidase enzyme activity for the methanol extract of raw fruits was determined to be 99.11 ± 1.61. In diabetic β-TC cells, glucose level was measured as 129 ± 2.03 mg/dL, and insulin amount was measured as 37.2 ± 0.02 mg/dL. Conclusions: The findings of our study seem to have important implications for future research, as Schinus molle L. may be a potential pharmaceutical candidate with important pharmacological activities. more...
- Published
- 2023
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26. Effects of cannabinoid and vanilloid receptor antagonists on nicotine induced relaxation response enhancement in rabbit corpus cavernosum
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İsmail Mert Vural, Gokce Sevim Ozturk Fincan, Derya Sebile Koc, Yagmur Okcay, Celil İlker Askin, Ayse Kubra Kibar, Sevil Ozger Ilhan, and Yusuf Sarioglu
- Subjects
cannabinoid receptors ,endocannabinoids ,nicotine ,penile erection ,smooth muscle ,Medicine - Abstract
Objective(s): Endocannabinoids and nicotine regulate the neurotransmitter release in different central and peripheral synapses. Various studies in the literature demonstrate the interaction between endocannabinoid and nicotinic systems, especially in the central nervous system. The interaction between nicotinic and endocannabinoid systems was investigated in this study. We aimed to show the effects of cannabinoid and vanilloid receptor antagonists on nicotine-induced relaxation response increases in rabbit corpus cavernosum.Materials and Methods: From a total of seven male albino rabbits, three or four equal strips were cut from each corpus cavernosum and inserted in isolated organ baths. Tissues were contracted with phenylephrine (3×10−5 M). After contraction reached a plateau, strips were stimulated with EFS, and with the stabilization of EFS relaxation responses, 10-4 M of nicotine was administered to tissues. After that, in order to investigate the effects of AM251 (CB1 antagonist), AM630 (CB2 inverse agonist) or capsazepine (a vanilloid receptor antagonist) were given to different tissues, after the resting period.Results: Nicotine (10−4 M) increased the EFS-induced relaxation responses (14.60%±2.94%, P more...
- Published
- 2022
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27. Karın Travmalı Hastalara Yaklaşım: Son 3 Yıllık Deneyimimiz
- Author
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HATİPOĞLU, R. Ahmet, GÖKÇE, S. Feridun, KARAGÜLLE, Erdal, and KARAKAYA, Kemal
- Published
- 2014
28. Appraisal of the antimicrobial and cytotoxic potentials of nanoparticles biosynthesized from the extracts of Pelargonium quercetorum Agnew
- Author
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Berrak Dumlupınar, Gökçe Şeker Karatoprak, Mehmet Fırat, and Esra Küpeli Akkol
- Subjects
pelargonium quercetorum ,geraniaceae ,silver nanoparticle ,antimicrobial ,cytotoxicity ,Biochemistry ,QD415-436 ,Biology (General) ,QH301-705.5 - Abstract
Aim: The aim of this study is the synthesis of nanosilver particles (AgNPs) from Pelargonium quercetorum Agnew. (Geraniaceae) and evaluation of the antimicrobial and the cytotoxic potential of AgNPs. Methods: The synthesized AgNPs were evaluated for antimicrobial and anticancer efficacy using the minimum inhibition concentration method and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide) assay. Results: The AgNPs inhibited approximately 90% the growth of gram-positive Staphylococcus aureus and gram-negative Esherichia coli and yeast Candida albicans pathogens at a concentration of 500 μg/mL. The synthesized AgNPs showed excellent toxicity in MCF-7 cells, and specifically, pq70 AgNP inhibited the growth of MCF-7 cells by 52% at a concentration of 3.125 μg/mL. Conclusion: It was determined that the AgNPs, which had been synthesized from extracts that contained a high phenolic composition, were smaller in size, and showed high anticancer and antimicrobial properties. more...
- Published
- 2021
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29. P2.01-40 Prognostic Importance of Sarcopeni and Inflammatory Statements in Stage III Non Small Cell Lung Carcinoma
- Author
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Gümüştepe, E., Akyürek, S., Arslan, Y., Gökay, E., and Çakir Gökçe, Ş.
- Published
- 2018
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30. Psychosocial status and quality of life in mothers of infants with colic
- Author
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Abaci, F. B., Gökçe, S., Tuygun, N., Can Demir Karacan, and Öner, Ö
- Subjects
surgical procedures, operative ,digestive system ,female genital diseases and pregnancy complications ,digestive system diseases - Abstract
We aimed to measure the psychosocial status and quality of life in mothers of babies with infantile colic (IC).
- Published
- 2013
31. Antioxidant Activity and Chemical Composition of Geranium Oil and Its Synergistic Potential against Pneumococci with Various Antibiotic Combinations
- Author
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Berrak Dumlupinar, Gökçe Şeker Karatoprak, Betül Demirci, Esra Küpeli Akkol, and Eduardo Sobarzo-Sánchez
- Subjects
Geranium oil ,S. pneumoniae ,antibiotics ,antioxidant ,antibacterial ,synergism ,Botany ,QK1-989 - Abstract
The essential oil of Pelargonium graveolens L. is valuable for its therapeutic benefits, so this study aimed to determine the synergistic effect of the combination of the essential oil of this plant with antibiotics instead of the extracts prepared with various solvents. In addition, the second goal of this study was to determine whether the essential oil combined with various antibiotics increased the overall killing activity in mouse macrophage cells with the aim of introducing an immunotherapeutic approach to the infection treatments used today. Herein, the volatile profile of Geranium oil (G.O) was analyzed using GC/MS. The current study sought to assess the synergistic characteristics of several antibiotic combinations using G.O against pneumococci, as well as the oil’s antioxidant and antimicrobial activities. The major components of the oil were citronellol, geraniol, and isomenthone. In the combinations of G.O and antibiotics, the synergism of the Streptococcus pneumoniae to antibiotics advanced. When the time-kill data were evaluated, G.O + antibiotic combinations quickly diminished the viable cell count of S. pneumoniae from the 6th h. In this study, the combined use of existing antibiotics used in infection treatments with G.O could improve antibiotic effectiveness and thus prevent bacteria from developing antibiotic resistance. more...
- Published
- 2023
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32. Traumatic Dislocation of the Globe into the Ethmoid Sinus
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Zafer Onaran, Gökçe Şimşek, and Onur Konuk
- Subjects
globe dislocation ,orbital trauma ,ethmoid sinus ,Medicine ,Ophthalmology ,RE1-994 - Abstract
Traumatic globe dislocation into the paranasal sinuses is a rare condition. Globe displacement with preserved integrity can result in functional and cosmetic recovery with rapid and appropriate intervention. In this article, we discuss the presentation and treatment of globe dislocation into the ethmoid sinus in a 36-year-old patient who presented to the emergency department with the complaint of vision loss due to a fall. more...
- Published
- 2021
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- View/download PDF
33. Effect of peritonsillar prilocaine infiltration on post-tonsillectomy pain in pediatric population
- Author
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Burak Mustafa Taş, Burak Erden, and Gökçe Şimşek
- Subjects
peritonsillar infiltration ,post-tonsillectomy pain ,prilocaine ,tonsillectomy ,visual analog scale ,peritonsiller infiltrasyon ,post-tonsillektomi ağrı ,prilokain ,tonsillektomi ,vizüel analog skala ,Medicine (General) ,R5-920 - Abstract
Purpose: This study aims to evaluate the efficacy of peritonsillar prilocaine in post-tonsillectomy pain by using the Visual Analog Scale (VAS). Materials and Methods: A total of 40 pediatric patients were included in this study. There were 20 patients in the prilocaine group (Group 1) and 20 patients in the control group (Group 2). In Group 1, peritonsillar prilocaine infiltration was performed. In Group 2, peritonsillar saline infiltration was performed. VAS scores of at the postoperative 1st, 4th, 12th and 24th hours and on the 2nd, 3rd, 4th, 5th, 6th and 7th days were evaluated. In addition, the presence of nausea and vomiting and the number of additional doses of intravenous paracetamol administered in the first 24 hours were evaluated. Results: When the groups were compared, a significant reduction in post-tonsillectomy pain was observed in the prilocaine group at the 1st, 4th and 12th hours compared to the control group. There was no significant difference between the two groups in other scores. There was no significant difference between the groups for nausea and vomiting and consumption of paracetamol values. Conclusion: Peritonsillar prilocaine infiltration was effective in post-tonsillectomy pain at the 1st, 4th and 12th hours postoperatively. Thus, peritonsillar prilocaine infiltration can be used in post-tonsillectomy pain because it is fast and effective. more...
- Published
- 2021
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- View/download PDF
34. Immunomodulatory and anti-inflammatory therapeutic potential of gingerols and their nanoformulations
- Author
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Çiğdem Yücel, Gökçe Şeker Karatoprak, Özlem Bahadır Açıkara, Esra Küpeli Akkol, Timur Hakan Barak, Eduardo Sobarzo-Sánchez, Michael Aschner, and Samira Shirooie
- Subjects
cytokine ,immunomodulatory ,ginger ,gingerol ,Zingiber officinale ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Ginger (Zingiber officinale Roscoe), a member of the Zingiberaceae family, is one of the most popular spices worldwide, known since ancient times, and used both as a spice and a medicinal plant. The phenolic compounds found in ginger are predominantly gingerols, shogaols, and paradols. Gingerols are the major phenolic compounds found in fresh ginger and contain mainly 6-gingerol as well as 4-, 5-, 8-, 10-, and 12-gingerols. Gingerols possess a wide array of bioactivities, such as antioxidant and anticancer, among others. Regarding the different array of biological activities and published data on the mechanisms underlying its action, the complex interaction between three key events, including inflammation, oxidative stress, and immunity, appears to contribute to a plethora of pharmacological activities of this compound. Among these, the immunomodulatory properties of these compounds, which attract attention due to their effects on the immune system, have been the focus of many studies. Gingerols can alleviate inflammation given their ability to inhibit the activation of protein kinase B (Akt) and nuclear factor kappa B (NF-κB) signaling pathways, causing a decrease in proinflammatory and an increase in anti-inflammatory cytokines. However, given their low bioavailability, it is necessary to develop new and more effective strategies for treatment with gingerols. In order to overcome this problem, recent studies have addressed new drug delivery systems containing gingerols. In this review, the immunomodulatory activities of gingerol and its underlying mechanisms of action combined with the contributions of developed nanodrug delivery systems to this activity will be examined. more...
- Published
- 2022
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35. MnCrxFe2−xO4 Nanoparticles: Magnetic and Microwave Absorption Properties
- Author
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Baykal, A., primary, Genç, F., additional, Elmal, A. Z., additional, Gökçe, S., additional, Sertkol, M., additional, and Sözeri, H., additional
- Published
- 2015
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36. Micronuclei frequencies in oral mucosal cells in patients undergoing nickel–titanium orthodontic archwires therapy
- Author
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Erdem, O., primary, Çetinkaya, S., additional, Kaplan, M., additional, Çırak, E., additional, Gökçe, S., additional, and Akay, C., additional
- Published
- 2015
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37. İletişim Aracı Olarak Dans: Ya da dans bir iletişim şekli midir?
- Author
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Gökçe Sönmemiş
- Subjects
Arts in general ,NX1-820 - Abstract
Bu makalenin önermesi; dansın önemli bir iletişim aracı olduğu ve duyguları, düşünceleri ifade ederken beden dilini, duruşları, pozları ve hareketleri bir araç olarak kullandığı yönündedir. Çağlar boyunca insan topluluklarının farklı amaçlar için dans ettiği gözlemlenmiştir. İnsanlar kadim zamanlardan beri dans etmiş olsalar da “insan neden dans eder?” sorusunun cevabı henüz tam olarak verilebilmiş değildir. Bu konu üzerine farklı tezler olmasına rağmen, insanın duygularını ifade edebilmek için dans ettiği tezi, en kabul gören tezlerden biridir. İnsanlar dini, sosyal, sanatsal hatta medikal tedavilere paralel ilerleyen hareket terapisi olarak dans edebilirler. Dans etmedeki nedenler farklı olsa da ana fikir çoğunlukla bir hikâye anlatmak, iletişim kurmak üzerinedir. Dini amaçla yapılan danslarda insan, kendisinden daha üstün bir varlık ile iletişim kurmaya çalışırken, sosyal veya sanatsal amaç ile yapılan danslarda ya kendi iç dünyasıyla ya da çevresindekilerle iletişim kurmayı hedefler. Bu makale, dansın iletişim yönünü ana hatları ile ele almayı amaçlar, ilgili kaynakların ve bilimsel araştırmaların incelenmesi, analizler ve literatür taraması ile elde edilen veriler doğrultusunda, dansın bir iletişim şekli olup olmadığını irdeler. Dans alanında Türkçe kaynakların sınırlı olması sebebi ile bu makale literatür azlığını bir nebze gidermeyi ve dansın iletişim yönü hakkında genel bir fikir vermeyi hedefler. more...
- Published
- 2021
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- View/download PDF
38. Droplet printing reveals the importance of micron-scale structure for bacterial ecology
- Author
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Ravinash Krishna Kumar, Thomas A. Meiller-Legrand, Alessandro Alcinesio, Diego Gonzalez, Despoina A. I. Mavridou, Oliver J. Meacock, William P. J. Smith, Linna Zhou, Wook Kim, Gökçe Su Pulcu, Hagan Bayley, and Kevin R. Foster more...
- Subjects
Science - Abstract
The spatial arrangement of bacterial strains and species within microbial communities is considered crucial for their ecology. Here, Krishna Kumar et al. use a droplet-based printing method to arrange different bacterial genotypes across a sub-millimetre array, and show that micron-scale changes in spatial distributions can drive major shifts in ecology. more...
- Published
- 2021
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- View/download PDF
39. Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors
- Author
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Gökçe Senger, Stefano Santaguida, and Martin H Schaefer
- Subjects
aneuploidy ,protein aggregation ,complex stoichiometry ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Aneuploidy, a state of chromosome imbalance, is a hallmark of human tumors, but its role in cancer still remains to be fully elucidated. To understand the consequences of whole-chromosome-level aneuploidies on the proteome, we integrated aneuploidy, transcriptomic, and proteomic data from hundreds of The Cancer Genome Atlas/Clinical Proteomic Tumor Analysis Consortium tumor samples. We found a surprisingly large number of expression changes happened on other, non-aneuploid chromosomes. Moreover, we identified an association between those changes and co-complex members of proteins from aneuploid chromosomes. This co-abundance association is tightly regulated for aggregation-prone aneuploid proteins and those involved in a smaller number of complexes. On the other hand, we observed that complexes of the cellular core machinery are under functional selection to maintain their stoichiometric balance in aneuploid tumors. Ultimately, we provide evidence that those compensatory and functional maintenance mechanisms are established through post-translational control, and that the degree of success of a tumor to deal with aneuploidy-induced stoichiometric imbalance impacts the activation of cellular protein degradation programs and patient survival. more...
- Published
- 2022
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- View/download PDF
40. 166 The relationship between social support and the social appearance anxiety in patients with breast cancer
- Author
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Özkaraman, A., primary, Fadiloglu, C., additional, Kösgeroglu, N., additional, Culha, I., additional, Alparslan, G. Balci, additional, and Gökçe, S., additional
- Published
- 2014
- Full Text
- View/download PDF
41. Effect of orthodontic brackets and different wires on radiofrequency heating and magnetic field interactions during 3-T MRI
- Author
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Görgülü, S, primary, Ayyıldız, S, additional, Kamburoğlu, K, additional, Gökçe, S, additional, and Ozen, T, additional
- Published
- 2014
- Full Text
- View/download PDF
42. Deterring White Collar Crimes within the Framework of Situational Crime Prevention Approach
- Author
-
Gökçe Sinem Erbuğa
- Subjects
crime ,white collar crime ,crime opportunities ,situational crime prevention approach ,suç ,beyaz yakalı suç ,durumsal suç önleme yaklaşımı ,suç fırsatları ,Economics as a science ,HB71-74 - Abstract
Birçok beyaz yakalı suçun, failin sahip olduğu mesleki fırsatları kötüye kullanılmasından kaynaklanması söz konusudur. Bu nedenle beyaz yaka suçlarının önüne geçilebilmesi için suç doğuran organizasyon temelli suç fırsatlarının engellenmesi gerekmektedir. Çalışma, söz konusu bu suç fırsatlarının kısıtlanması yoluyla beyaz yakalı suçların önlenebileceğini ortaya koymayı amaçlamaktadır. Bu doğrultuda çalışmada durumsal suç önleme yaklaşımından yararlanılmaktadır. Çalışmada, durumsal suç önleme yaklaşımı tarafından öngörülen suç önleme tekniklerinin beyaz yaka suçlardaki uygulanabilirliği değerlendirilmektedir. Bu tekniklerin ortaya konulmasının ardından durumsal suç önleme yaklaşımı dahilinde şirketlerin alması gereken önlemlere yer verilmiştir. Ancak sonuç itibariyle görülmektedir ki durumsal suç önleme, beyaz yaka suç olaylarını azaltmada etkili bir yaklaşım olsa da beyaz yaka suç olaylarının tamamen önüne geçememektedir. more...
- Published
- 2020
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- View/download PDF
43. Cytotoxic Activity of Schinus molle L. Berries and Leaves
- Author
-
Selen İlgün and Gökçe Şeker Karatoprak
- Subjects
Schinus molle ,cytotoxicity ,Anacardiaceae ,Medicine - Abstract
Schinus molle is a perennial tree commonly known as “Pirul” in Mexico. This aromatic plant belongs to the Anacardiaceae family and the antibacterial, antifungal, insecticidal and cytotoxic activities of its bioactive essential oils have been previously investigated. Locally, the plant is mainly used as an analgesic, antiseptic, antibacterial, purgative and diuretic agent. In this study, the plant, which is generally grown as an ornamental plant on the Mediterranean coast of Turkey, was evaluated in terms of its cytotoxic properties based on its secondary metabolites. Raw and ripe fruits, together with the plant’s leaves, were collected and extracted using different solvents. Both 70% methanol and water extracts of leaves, ripe fruits and raw fruits were prepared. The six different extracts obtained were tested in cell lines of humans’ most common cancer types (Du-145 prostate cancer, CaCo-2 colon cancer and MCF-7 breast cancer). As a result, methanol extracts prepared from the ripe fruits of the plant decreased the viability of three different cancer cells, especially MCF-7 and Du-145 cell lines, at low concentrations below 50%. Particularly in the MCF-7 cell line, the viability at 15 µg/mL was calculated as 46.03 ± 1.19%. While the cell line which was least effected by the extracts was CaCo-2, the extracts with the most negligible antiproliferative effect were the water extracts of the leaves and the raw and ripe fruits. more...
- Published
- 2022
- Full Text
- View/download PDF
44. Phytochemical Profiles, Antioxidant, Cytotoxic, and Anti-Inflammatory Activities of Traditional Medicinal Plants: Centaurea pichleri subsp. pichleri, Conyza canadensis, and Jasminum fruticans
- Author
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Derya Çiçek Polat, Selen İlgün, Gökçe Şeker Karatoprak, Esra Küpeli Akkol, and Raffaele Capasso
- Subjects
Centaurea sp. ,Conyza sp. ,Jasminum sp. ,antioxidant ,anti-inflammatory ,cytotoxic activity ,Organic chemistry ,QD241-441 - Abstract
Centaurea pichleri subsp. pichleri, Conyza canadensis, and Jasminum fruticans are traditionally used plants grown in Turkey. Methanol extracts were obtained from these plants and pharmacological activity studies and phytochemical analyses were carried out. To evaluate the phytochemical composition, spectrophotometric and chromatographic techniques were used. The extracts were evaluated for antioxidant activity by DPPH●, ABTS●+ radical scavenging, and FRAP assays. The cytotoxic effects of the extracts were investigated on DU145 prostate cancer and A549 lung cancer cell lines. The anti-inflammatory effects of extracts were investigated on the NO amount, TNF-α, IFN-γ, and PGE 2 levels in lipopolysaccharide-stimulated Raw 264.7 cells. The richest extract in terms of phenolic compounds (98.19 ± 1.64 mgGAE/gextract) and total flavonoids (21.85 ± 0.64 mgCA/gextract) was identified as C. pichleri subsp. pichleri methanol extract. According to antioxidant activity determinations, the C. pichleri subsp. pichleri extract was found to be the most active extract. Finally, the C. pichleri subsp. pichleri methanol extract was revealed to be the most effective inhibitor of viability in the cytotoxic activity investigation, and the extract with the best anti-inflammatory action. The findings point to C. pichleri subsp. pichleri as a promising source of bioactive compounds in the transition from natural sources to industrial uses, such as new medications, cosmeceuticals, and nutraceuticals. more...
- Published
- 2022
- Full Text
- View/download PDF
45. A Systematic Review of Transcriptional Dysregulation in Huntington’s Disease Studied by RNA Sequencing
- Author
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Bimala Malla, Xuanzong Guo, Gökçe Senger, Zoi Chasapopoulou, and Ferah Yildirim
- Subjects
huntington’s disease ,transcriptional dysregulation ,RNA sequencing ,transcription factors ,epigenetic regulators ,Genetics ,QH426-470 - Abstract
Huntington’s disease (HD) is a chronic neurodegenerative disorder caused by an expansion of polyglutamine repeats in exon 1 of the Huntingtin gene. Transcriptional dysregulation accompanied by epigenetic alterations is an early and central disease mechanism in HD yet, the exact mechanisms and regulators, and their associated gene expression programs remain incompletely understood. This systematic review investigates genome-wide transcriptional studies that were conducted using RNA sequencing (RNA-seq) technology in HD patients and models. The review protocol was registered at the Open Science Framework (OSF). The biomedical literature and gene expression databases, PubMed and NCBI BioProject, Array Express, European Nucleotide Archive (ENA), European Genome-Phenome Archive (EGA), respectively, were searched using the defined terms specified in the protocol following the PRISMA guidelines. We conducted a complete literature and database search to retrieve all RNA-seq-based gene expression studies in HD published until August 2020, retrieving 288 articles and 237 datasets from PubMed and the databases, respectively. A total of 27 studies meeting the eligibility criteria were included in this review. Collectively, comparative analysis of the datasets revealed frequent genes that are consistently dysregulated in HD. In postmortem brains from HD patients, DNAJB1, HSPA1B and HSPB1 genes were commonly upregulated across all brain regions and cell types except for medium spiny neurons (MSNs) at symptomatic disease stage, and HSPH1 and SAT1 genes were altered in expression in all symptomatic brain datasets, indicating early and sustained changes in the expression of genes related to heat shock response as well as response to misfolded proteins. Specifically in indirect pathway medium spiny neurons (iMSNs), mitochondria related genes were among the top uniquely dysregulated genes. Interestingly, blood from HD patients showed commonly differentially expressed genes with a number of brain regions and cells, with the highest number of overlapping genes with MSNs and BA9 region at symptomatic stage. We also found the differential expression and predicted altered activity of a set of transcription factors and epigenetic regulators, including BCL6, EGR1, FOSL2 and CREBBP, HDAC1, KDM4C, respectively, which may underlie the observed transcriptional changes in HD. Altogether, our work provides a complete overview of the transcriptional studies in HD, and by data synthesis, reveals a number of common and unique gene expression and regulatory changes across different cell and tissue types in HD. These changes could elucidate new insights into molecular mechanisms of differential vulnerability in HD.Systematic Review Registration:https://osf.io/pm3wq more...
- Published
- 2021
- Full Text
- View/download PDF
46. Protein Complex Organization Imposes Constraints on Proteome Dysregulation in Cancer
- Author
-
Gökçe Senger and Martin H. Schaefer
- Subjects
protein-protein interactions ,cancer ,protein complexes ,abundance dysregulation ,stoichiometry ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Protein assembly is a highly dynamic process and proteins can interact in different ways and stoichiometries within a complex. The importance of maintaining protein stoichiometry for complex function and avoiding aggregation of orphan subunits has been demonstrated. However, how exactly the organization of proteins into complexes constrains differential protein abundance in extreme cellular conditions like cancer, where a lot of protein abundance changes occur, has not been systematically investigated. To study this, we collected proteomic data made available by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) to quantify proteomic changes during carcinogenesis and systematically tested five interaction types in complexes to investigate which of these features impact on protein abundance correlation patterns in cancer. We found that higher than expected fraction of protein complex subunits does not show changes in their abundances compared to those in the normal samples. Furthermore, we found that the way proteins interact in complexes indeed constrains their co-abundance patterns. Our results highlight the role of the interactions between the proteins and the need of cancer cells to deal with aberrant changes in protein abundance. more...
- Published
- 2021
- Full Text
- View/download PDF
47. Phytochemical Composition and Biological Activities of Arctium minus (Hill) Bernh.: A Potential Candidate as Antioxidant, Enzyme Inhibitor, and Cytotoxic Agent
- Author
-
Selen İlgün, Gökçe Şeker Karatoprak, Derya Çiçek Polat, Esra Köngül Şafak, Gülsüm Yıldız, Esra Küpeli Akkol, and Eduardo Sobarzo-Sánchez
- Subjects
Arctium minus ,Asteraceae ,antioxidant ,enzyme inhibition ,cytotoxic activity ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Arctium minus (Hill) Bernh. (Asteraceae), which has a wide distribution area in Turkey, is a medicinally important plant. Eighty percent methanol extracts of the leaf, flower head, and root parts of A. minus were prepared and their sub-fractions were obtained. Spectrophotometric and chromatographic (high-performance liquid chromatography) techniques were used to assess the phytochemical composition. The extracts were evaluated for antioxidant activity by diphenyl-2-picrylhydrazil radical (DPPH●), 2,2′-Azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS●+) radical scavenging, and β-carotene linoleic acid bleaching assays. Furthermore, the extracts were subjected to α-amylase, α-glucosidase, lipoxygenase, and tyrosinase enzyme inhibition tests. The cytotoxic effects of extracts were investigated on MCF-7 and MDA-MB-231 breast cancer cell lines. The richest extract in terms of phenolic compounds was identified as the ethyl acetate sub-fraction of the root extract (364.37 ± 7.18 mgGAE/gextact). Furthermore, chlorogenic acid (8.855 ± 0.175%) and rutin (8.359 ± 0.125%) were identified as the primary components in the leaves’ ethyl acetate sub-fraction. According to all methods, it was observed that the extracts with the highest antioxidant activity were the flower and leaf ethyl acetate fractions. Additionally, ABTS radical scavenging activity of roots’ ethyl acetate sub-fraction (2.51 ± 0.09 mmol/L Trolox) was observed to be as effective as that of flower and leaf ethyl acetate fractions at 0.5 mg/mL. In the β-carotene linoleic acid bleaching assay, leaves’ methanol extract showed the highest antioxidant capacity (1422.47 ± 76.85) at 30 min. The enzyme activity data showed that α-glucosidase enzyme inhibition of leaf dichloromethane extract was moderately high, with an 87.12 ± 8.06% inhibition value. Lipoxygenase enzyme inhibition was weakly detected in all sub-fractions. Leaf methanol extract, leaf butanol, and root ethyl acetate sub-fractions showed 99% tyrosinase enzyme inhibition. Finally, it was discovered that dichloromethane extracts of leaves, roots, and flowers had high cytotoxic effects on the MDA-MB-231 cell line, with IC50 values of 21.39 ± 2.43, 13.41 ± 2.37, and 10.80 ± 1.26 µg/mL, respectively. The evaluation of the plant extracts in terms of several bioactivity tests revealed extremely positive outcomes. The data of this study, in which all parts of the plant were investigated in detail for the first time, offer promising results for future research. more...
- Published
- 2022
- Full Text
- View/download PDF
48. bis(N,N-diethylnicotinamide) p-chlorobenzoate complexes of Ni(II), Zn(II) and Cd(II)
- Author
-
Köse, D. A., primary, Gökçe, G., additional, Gökçe, S., additional, and Uzun, İ., additional
- Published
- 2008
- Full Text
- View/download PDF
49. Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases
- Author
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Esra Küpeli Akkol, Irem Tatlı Çankaya, Gökçe Şeker Karatoprak, Elif Carpar, Eduardo Sobarzo-Sánchez, and Raffaele Capasso
- Subjects
Alzheimer's diseases ,anxiety ,depression ,Parkinson's disease ,natural compound ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Psychiatric disorders are frequently encountered in many neurological disorders, such as Alzheimer’s and Parkinson diseases along with epilepsy, migraine, essential tremors, and stroke. The most common comorbid diagnoses in neurological diseases are depression and anxiety disorders along with cognitive impairment. Whether the underlying reason is due to common neurochemical mechanisms or loss of previous functioning level, comorbidities are often overlooked. Various treatment options are available, such as pharmacological treatments, cognitive-behavioral therapy, somatic interventions, or electroconvulsive therapy. However oral antidepressant therapy may have some disadvantages, such as interaction with other medications, low tolerability due to side effects, and low efficiency. Natural compounds of plant origin are extensively researched to find a better and safer alternative treatment. Experimental studies have shown that phytochemicals such as alkaloids, terpenes, flavonoids, phenolic acids as well as lipids have significant potential in in vitro and in vivo models of psychiatric disorders. In this review, various efficacy of natural products in in vitro and in vivo studies on neuroprotective and their roles in psychiatric disorders are examined and their neuro-therapeutic potentials are shed light. more...
- Published
- 2021
- Full Text
- View/download PDF
50. Synthesis and Calcium Modulatory Activity of 3-Alkyloxy- carbonyl-4-(disubstituted)aryl-5-oxo-1,4,5,6,7,8-hexa-hydroquinoline Derivatives
- Author
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Simsek, Rahime, primary, Öztürk, Gökçe S., additional, Vural, I. Mert, additional, Gündüz, Miyase G., additional, Sarıoǧlu, Yusuf, additional, and Safak, Cihat, additional
- Published
- 2007
- Full Text
- View/download PDF
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