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1. The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results

Author

Schotten, Ulrich, Hatem, Stephane, Ravens, Ursula, Jaïs, Pierre, Müller, Frank-Ulrich, Goette, Andres, Rohr, Stephan, Antoons, Gudrun, Pieske, Burkert, Scherr, Daniel, Oto, Ali, Casadei, Barbara, Verheule, Sander, Cartlidge, David, Steinmeyer, Klaus, Götsche, Thorsten, Dobrev, Dobromir, Kockskämper, Jens, Lendeckel, Uwe, Fabritz, Larissa, Kirchhof, Paulus, and Camm, A. John

Published
2015
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2. The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results

Author

Schotten, Ulrich, Hatem, Stephane, Ravens, Ursula, Jaïs, Pierre, Müller, Frank-Ulrich, Goette, Andres, Rohr, Stephan, Antoons, Gudrun, Pieske, Burkert, Scherr, Daniel, Oto, Ali, Casadei, Barbara, Verheule, Sander, Cartlidge, David, Steinmeyer, Klaus, Götsche, Thorsten, Dobrev, Dobromir, Kockskämper, Jens, Lendeckel, Uwe, Fabritz, Larissa, Kirchhof, Paulus, Camm, A. John, Schotten, Ulrich, Hatem, Stephane, Ravens, Ursula, Jaïs, Pierre, Müller, Frank-Ulrich, Goette, Andres, Rohr, Stephan, Antoons, Gudrun, Pieske, Burkert, Scherr, Daniel, Oto, Ali, Casadei, Barbara, Verheule, Sander, Cartlidge, David, Steinmeyer, Klaus, Götsche, Thorsten, Dobrev, Dobromir, Kockskämper, Jens, Lendeckel, Uwe, Fabritz, Larissa, Kirchhof, Paulus, and Camm, A. John

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia in the general population. As an age-related arrhythmia AF is becoming a huge socio-economic burden for European healthcare systems. Despite significant progress in our understanding of the pathophysiology of AF, therapeutic strategies for AF have not changed substantially and the major challenges in the management of AF are still unmet. This lack of progress may be related to the multifactorial pathogenesis of atrial remodelling and AF that hampers the identification of causative pathophysiological alterations in individual patients. Also, again new mechanisms have been identified and the relative contribution of these mechanisms still has to be established. In November 2010, the European Union launched the large collaborative project EUTRAF (European Network of Translational Research in Atrial Fibrillation) to address these challenges. The main aims of EUTRAF are to study the main mechanisms of initiation and perpetuation of AF, to identify the molecular alterations underlying atrial remodelling, to develop markers allowing to monitor this processes, and suggest strategies to treat AF based on insights in newly defined disease mechanisms. This article reports on the objectives, the structure, and initial results of this network

Published
2017

3. The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results

Author

Schotten, Ulrich, Hatem, Stephane, Ravens, Ursula, Jaïs, Pierre, Müller, Frank-Ulrich, Goette, Andres, Rohr, Stephan, Antoons, Gudrun, Pieske, Burkert, Scherr, Daniel, Oto, Ali, Casadei, Barbara, Verheule, Sander, Cartlidge, David, Steinmeyer, Klaus, Götsche, Thorsten, Dobrev, Dobromir, Kockskämper, Jens, Lendeckel, Uwe, Fabritz, Larissa, Kirchhof, Paulus, Camm, A. John, Schotten, Ulrich, Hatem, Stephane, Ravens, Ursula, Jaïs, Pierre, Müller, Frank-Ulrich, Goette, Andres, Rohr, Stephan, Antoons, Gudrun, Pieske, Burkert, Scherr, Daniel, Oto, Ali, Casadei, Barbara, Verheule, Sander, Cartlidge, David, Steinmeyer, Klaus, Götsche, Thorsten, Dobrev, Dobromir, Kockskämper, Jens, Lendeckel, Uwe, Fabritz, Larissa, Kirchhof, Paulus, and Camm, A. John

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia in the general population. As an age-related arrhythmia AF is becoming a huge socio-economic burden for European healthcare systems. Despite significant progress in our understanding of the pathophysiology of AF, therapeutic strategies for AF have not changed substantially and the major challenges in the management of AF are still unmet. This lack of progress may be related to the multifactorial pathogenesis of atrial remodelling and AF that hampers the identification of causative pathophysiological alterations in individual patients. Also, again new mechanisms have been identified and the relative contribution of these mechanisms still has to be established. In November 2010, the European Union launched the large collaborative project EUTRAF (European Network of Translational Research in Atrial Fibrillation) to address these challenges. The main aims of EUTRAF are to study the main mechanisms of initiation and perpetuation of AF, to identify the molecular alterations underlying atrial remodelling, to develop markers allowing to monitor this processes, and suggest strategies to treat AF based on insights in newly defined disease mechanisms. This article reports on the objectives, the structure, and initial results of this network

4. The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results.

Author

Schotten U, Hatem S, Ravens U, Jaïs P, Müller FU, Goette A, Rohr S, Antoons G, Pieske B, Scherr D, Oto A, Casadei B, Verheule S, Cartlidge D, Steinmeyer K, Götsche T, Dobrev D, Kockskämper J, Lendeckel U, Fabritz L, Kirchhof P, and Camm AJ

Subjects
Cooperative Behavior, Electrocardiography, Europe, Humans, Atrial Fibrillation diagnosis, Atrial Fibrillation genetics, Atrial Fibrillation physiopathology, Atrial Remodeling, Translational Research, Biomedical trends
Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia in the general population. As an age-related arrhythmia AF is becoming a huge socio-economic burden for European healthcare systems. Despite significant progress in our understanding of the pathophysiology of AF, therapeutic strategies for AF have not changed substantially and the major challenges in the management of AF are still unmet. This lack of progress may be related to the multifactorial pathogenesis of atrial remodelling and AF that hampers the identification of causative pathophysiological alterations in individual patients. Also, again new mechanisms have been identified and the relative contribution of these mechanisms still has to be established. In November 2010, the European Union launched the large collaborative project EUTRAF (European Network of Translational Research in Atrial Fibrillation) to address these challenges. The main aims of EUTRAF are to study the main mechanisms of initiation and perpetuation of AF, to identify the molecular alterations underlying atrial remodelling, to develop markers allowing to monitor this processes, and suggest strategies to treat AF based on insights in newly defined disease mechanisms. This article reports on the objectives, the structure, and initial results of this network., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.)

Published
2015
Full Text
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