1. Can the number of eosinophils in adenoid and tonsil tissue determine the allergy in children?
- Author
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Ozgur Kulahci, Osman Kürşat Arıkan, Nur Yücel Ekici, Orhan Görgülü, Cemile Durmaz, and Gül Yucel
- Subjects
Male ,medicine.medical_specialty ,Allergy ,medicine.medical_treatment ,Palatine Tonsil ,Adenoid ,medicine.disease_cause ,Adenoidectomy ,Leukocyte Count ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,Eosinophilia ,otorhinolaryngologic diseases ,Humans ,Medicine ,Prospective Studies ,Child ,030223 otorhinolaryngology ,Prospective cohort study ,Skin Tests ,Tonsillectomy ,business.industry ,General Medicine ,Allergens ,respiratory system ,medicine.disease ,Rhinitis, Allergic ,Dermatology ,Eosinophils ,stomatognathic diseases ,medicine.anatomical_structure ,ROC Curve ,030228 respiratory system ,Otorhinolaryngology ,Child, Preschool ,Tonsil ,Adenoids ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business - Abstract
Previous reports have indicated the association of allergy with Waldeyer's ring. The aim of this prospective study was to evaluate the correlation between the allergy and the number of eosinophils in the adenoid and tonsil tissue.101 children who were underwent adenoidectomy and/or tonsillectomy were prospectively enrolled in this study. 46 children who had positive skin-prick test for at least one of the allergen panel were sensitized and 55 children were nonsensitized as a result of skin-prick test. Hematoxylin-eosin stained sections were examined under 400× magnification in a blinded fashion in 10 random sections for all samples and compared the groups.The number of eosinophils in adenoid and tonsil tissue was significantly higher in sensitized patients. The number of eosinophils in the adenoid and tonsil samples also were interrelated too (p 0.001, kappa coefficient: 0.617). As a result of ROC analysis, patients with a cut-off of ≥5 eosinophils was in the sensitized group for adenoid samples [Sensitivity value: 72.09 and specifity value: 91.84]. Patients with a cut-off of ≥3 eosinophils are in the sensitized group for tonsil samples [Sensitivity value: 52.94 and specifity value: 92.11].Presence of sensitization can be distinguished by looking at the number of eosinophils in the adenoid and tonsil tissue. It can be used to determine whether the patient is allergic or not. Examination of the routine hematoxylin-eosin stained adenotonsillary specimen for eosinophilia will guide us the diagnosis and treatment of allergic rhinitis and also reduce the cost considerably.
- Published
- 2018
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