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Funding Acknowledgements Type of funding sources: None. Background Conduction disturbances determining pacemaker implantation are a significant concern in patients undergoing Transcatheter Aortic Valve Implantation (TAVI), a procedure that is nowadays spreading even in the low-risk population. OBJECTIVE The aim of the study was to evaluate the role of the parahisian pacing, a method to directly identify the conduction system anatomical variability, in predicting the iatrogenic damage risk conditioning pacemaker implantation after TAVI. Methods Between October 2021 and November 2022 we prospectively collected clinical features, ECG, procedural and imaging data (cardiac CT and echocardiography) of every patient who underwent electrophysiological study for pre-existing or worsening conduction disorders within 48 hours after TAVI procedures in our centre. After having recorded the HV interval, parahisian stimulation at decreasing energy output was performed (CL 600 ms, 25V to 0.5V x 2 ms) with definition of the loss of capture pattern related to the three anatomical variations of His bundle described by Kawashima (1). Fisher’s exact test was used for statistical analysis; p-value Results Out of 110 TAVI performed, a total of 31 patients with conduction disorders have been studied. Patients who developed permanent 3rd degree AV block after the procedure were excluded. Mean age was 82.6±4.4 years; 21 patients (67.7%) were males. 11 patients (35.5%) had a pre-existing conduction disorder worsened after TAVI, 13 patients (41.9%) developed newly-onset LBBB; 8 (25.8%) also developed 1st degree AV block. The total number of patients who underwent PM implantation was 16 (51.6%). The anatomical variables (membranous septum Conclusions Parahisian stimulation can be a useful tool to define the conduction system anatomical variability. It can also be helpful to predict the conduction system damage risk during TAVI, conditioning PM implantation. Our data need to be confirmed in a larger population.

Funding Acknowledgements Type of funding sources: None. Background Brugada syndrome (BrS) is an inherited disease characterized by an increased risk of sudden cardiac death (SCD). According to the latest ESC guidelines, provocation with sodium channel blocker test is less specific than previously thought, especially in asymptomatic patients(1). In these cases, in which the diagnosis of BrS itself can be controversial, management currently consists in clinical follow-up only. However, we still observe a big gap between the patient’s perception and medical recommendations of living a normal life. Objective The goal of this study was to analyze exercise habits before and after positive ajmaline testing (AT), focusing on its psychological impact on a population of low-risk young patients. Methods We enrolled all-comers patients with ajmaline-induced Brugada type 1 pattern who came to our department between 2015 and 2022. Patients were asked to rate their heart-focused anxiety using the German version of the Cardiac Anxiety Questionnaire (CAQ) (2) at last medical contact after ajmaline challenge. The intensity of habitual physical exercise was estimated in METs and divided in 3 categories: mild (6 METs). Different groups were compared using Student’s t-test for continuous variables. Significance level was set to p Results A total of 87 patients resulted positive to ajmaline challenge; among these, 16 (18.4%) underwent EPS and 4 (4.6%) of them underwent ICD implantation. Therefore, our population included 83 patients. Mean age was 45.1±13.5 years; M/F ratio was 1.4/1. 12 patients (14.5%) had family history of SCD. Mean follow-up duration was 31.6±25.3 months. After positive AT, 5 patients (5.7%) did intense physical activity (PA), 27 (31.0%) did moderate PA, 51 (58.6%) were sedentary or practiced low-intensity PA. Mean CAQ score in the overall population was 19.1±6.6 points (fig. 1A), noticeably higher than the general population (2). As shown in fig. 1B, anxiety levels were significantly lower in patients who did almost moderate PA (p=0.03), independently from previous sport habits. This suggests sport to be a protective factor against anxiety. A total of 23 people (27.7%) reduced PA (fig. 2). We compared this population to the two groups of patients whose habits were not affected by the test: respectively high-high (n=22; 25.3%) and low-low groups (n=34; 39.1%). Anxiety in high-low group patients was not significantly different from the other two (fig. 1C), although it was higher than the general population. Conclusions After positive AT, many patients lead a sedentary lifestyle. Regardless of this, anxiety after the test is higher than the normal population. Anxiety levels do not change significantly between patients who reduced PA and those who did not change their habits. Further investigation is needed to assess the trade-offs between individual arrhythmic risk and global cardiovascular risk due to sedentary lifestyle in these patients.

Funding Acknowledgements Type of funding sources: None. Radiofrequency (RF) catheter ablation is an effective method for treatment of typical cavo-tricuspid isthmus (CTI) dependent atrial flutter. However, despite the widespread use of contact force irrigated catheter, 11% of patients don’t achieve a first-pass CTI block, requiring additional RF applications or additional line during the same or a second procedure. From an anatomical point of view, CTI is composed of discrete bundles of muscle with intervening connective tissue, suggesting that its conduction proprieties are dependent of the anatomic architecture of the bundles. The maximum voltage-guided (MGV) ablation technique targets high-voltage electrograms along CTI to ablate the functionally active anatomic muscle bundle, without drawing a complete anatomic line. [1;2] Purpose The aim of this study was to evaluate the efficacy of maximum voltage and activation-guided ablation (MVG/LAT) for CTI atrial flutter in real-world setting. Methods This was a prospective observational study in which all patients undergoing CTI atrial flutter ablation at the Electrophysiology Laboratory of our Department from 01/2021 to 10/2022 were recruited. Patients who were undergoing the ablation procedure after having already made an unsuccessful attempt of the same were excluded from the study. Substrate and activation mapping of CTI, both during flutter and during pacing from the proximal coronary sinus (CSp), was performed in all patients, identifying the earliest activated high-voltage channels, without the use of fluoroscopy, using the Smart-Touch SF catheter (CARTO 3, V7, Biosense Webster). High-voltage channels were validate also during lateral RA pacing. CTI ablation was performed only in channels with high voltage and early activation (W 45, AI 500). Bidirectional CTI block were validate by differential atrial pacing maneuvers and activation mapping during pacing from CSp. Results Procedural data of 39 patients were evaluated (mean age 68±13 years; men 92.6%; mean right atrium volume 149 mL). The mean number of points taken per map per patient was 1151. Bipolar thresholds were customized (0.5-2.5 mV) with the aim of better visualizing high-voltage channels. In 20/39(51.2%) patients ablation was performed during atrial flutter, in 19/39(48.8%) during pacing from proximal CS. In 19/39(48.8%) patients high-voltage channels were not detected at the central isthmus line (6 o'clock, LAO). The median number of RF applications to achieve bidirectional block of the CTI were 6 (1-20) in all patients (p=NS) (Figure 1,2). During a mean follow-up of 260 days (90-531) no recurrences were documented in any patient. Conclusions MVG/LAT-guided ablation, targeting selectively conductive muscle fibers, decreases the number of RF applications and improves efficacy, mostly in patients with challenging anatomies.

BackgroundGlobally nearly 20% of cardiovascular disease deaths were attributable to air pollution. Out-of-hospital cardiac arrest (OHCA) represents a major public health problem, therefore, the identification of novel OHCA triggers is of crucial relevance. The aim of the study was to evaluate the association between air pollution (short-, mid-and long-term exposure) and out-of-hospital cardiac arrest (OHCA) risk, during a 7 years-period from a highly polluted urban area with a high density of automated external defibrillators (AEDs).Methods and resultsOHCA were prospectively collected from the “Progetto Vita Database” between 01/01/2010 to 31/12/2017; day-by-day air pollution levels were extracted from the Environmental Protection Agency (ARPA) stations. Electrocardiograms of OHCA interventions were collected from the AEDs data cards. Day-by-day particulate matter (PM) 2.5 and 10, ozone (O3), carbon monoxide (CO) and nitrogen dioxide (NO2) levels were measured. A total of 880 OHCAs occurred in 748 days. A significantly increased in OHCA risk with the progressive increase in PM 2.5, PM 10, CO and NO2 levels was found. After adjustment for temperature and seasons, a 9% and 12% increase of OHCA risk for each 10 μg/m3 increase of PM 10 (p< 0.0001) and PM 2.5 (p< 0.0001) levels was found. Air pollutants levels were associated with both asystole and shockable rhythm risk while no correlation was found with pulseless electrical activity.ConclusionsShort-term and mid-term exposure to PM 2.5 and PM 10 is independently associated with the risk of OHCA due to asystole or shockable rhythm.

Aims Transcatheter patent foramen ovale (PFO) closure has been shown to lower recurrent stroke in patients with cryptogenic stroke (CS) or transient ischemic attack (TIA) with an indication for closure. However, the incidence of recurrent stroke is not negligible and underlying pathogenic mechanisms remain largely unknown. We sought to evaluate the prevalence of recurrent CS/TIA and to assess its predictors after transcatheter PFO closure. Methods We enrolled consecutive patients who underwent PFO closure for secondary prevention of neurological ischemic events at the University Hospital of Parma between 2006 and 2021. For each subject, CS/TIA index event was diagnosed after exclusion of alternative etiologies, PFO features were characterized by transesophageal echocardiography (TEE), the Risk of Paradoxical Embolism (ROPE) score was retrospectively assessed and the presence of migraine was investigated. Clinical follow–up was scheduled with outpatient visits at 3 – 12 months and yearly thereafter device implantation; the primary outcome was the recurrence of any ischemic neurological event. Results We enrolled a total of 169 patients with mean Risk of Paradoxical Embolism (ROPE) score at hospital admission of 6.4 ± 1.5. The primary indication for PFO closure was previous CS (94 [55.6%] subjects), followed by TIA (75 [44.4%]). Among patients with complete outcome data (n= 154), after a median follow–up of 112 months, recurrent cerebral ischemia occurred in 13 [8.4%], with an annualized rate of 0.92/100 patients. The presence of obesity [OR 5.268, p = 0.018], ROPE score < 7 [OR 5.991, p = 0.035] and migraine [OR = 5.932 p = 0.012] were independent positive predictors of recurrent stroke/TIA after PFO closure. Conclusion In our study, recurrent cerebral events after PFO closure were not negligible, with an annualized rate of 0.92/100 patients, consistent with prior research. Multiple heterogeneous predictors were identified: the presence of obesity, ROPE score < 7 and migraine were independent positive predictors of recurrent stroke/TIA after PFO closure

Background and aim of the work Marfan Syndrome is a genetic disorder that determines histopathological alterations of the aortic vascular wall leading to increased inflammatory component. The peri–vascular adipose tissue attenuation is a method able to capture localized vascular inflammation by mapping spatial changes of perivascular tissue attenuation on computed tomography. Methods We measured peri–vascular adipose tissue attenuation around the ascending aorta in three consecutive subjects with confirmed genetic diagnosis of Marfan Syndrome. All subjects received the genetic diagnosis of fibrillin–1 gene mutation as part of the family screening of patients with known Marfan Syndrome. Chest computed tomography was performed in such asymptomatic subjects after genetic confirmation of Marfan Syndrome. None of these subjects showed aortic aneurysms or suffered from chronic inflammatory/infectious disease. Results In the three subjects identified with Marfan Syndrome the value of aortic peri–vascular adipose tissue attenuation measured at chest computed tomography was higher than normal and the volume of aortic peri–vascular adipose tissue was lower. Conclusion These preliminary observations suggest that peri–vascular adipose tissue attenuation is unexpectedly high in patients with Marfan Syndrome, notwithstanding the normal aortic diameter at the time of computed tomography. Whether this observation may find a clinical use in suspected Marfan Syndrome or in predicting aortic complications in Marfan Syndrome is worth to be assessed in prospective studies.

Transcatheter left atrial appendage occlusion (LAAO) has emerged as a reliable tool to prevent thromboembolic events, in particular ischemic stroke, in patients with atrial fibrillation (AF) in the absence of mitral stenosis/valve prosthesis and contraindication to oral anticoagulation (OAC). Antiplatelet therapy (APT) is required after device implantation to prevent device–related thrombus (DRT). Previous studies provided conflicting results on the optimal APT regimen after LAAO. Thus, herein we aimed at assessing the comparative effectiveness and safety of distinct APT regimens. We conducted a real–world single–center observational study including consecutive AF patients that underwent LAAO at the University Hospital of Parma between October 2010 and June 2021. Clinical follow–up included all successfully implanted patients. Primary endpoint was net efficacy outcome, a composite of any ischemic or hemorrhagic event. Secondary endpoints were ischemic (any of the following: ischemic stroke, transient ischemic attack [TIA], DRT, systemic embolism) and hemorrhagic (major [≥3] bleedings according to Bleeding Academic Research Consortium [BARC] classification) complications alone. We enrolled a total of 130 patients (median age 77.0 [72.7;81.0] years; 78 [60.0%] men). History of hemorrhagic stroke in OAC (74 [56.9%]) was the main indication for LAAO. Technical procedure success was achieved in 123 (94.6%) patients. According to multidisciplinary team evaluation, immediately after LAAO, 39 (31.7%) patients received short (≤ 1 month)–dual APT (DAPT) consisting of cardioaspirin and clopidogrel, 35 (28.5%) long (>1, ≤12 months)–DAPT and 49 (39.8%) single APT (SAPT). At a median follow–up of 32 months, the incidence of primary endpoint was significantly lower in short–DAPT group (3 [7.7%] vs. 7 [20.0%] in long–DAPT vs. 14 [28.6%] in SAPT, p = 0.049], mainly driven by a lower occurrence of bleeding endpoint (0 [0.0] vs. 4 [11.4%] in long–DAPT vs. 9 [18.4%] in SAPT, p = 0.020) without differences in the incidence of ischemic endpoint (p = 0.916). Finally, comparison of the Kaplan–Meier curves showed that short–DAPT group had a higher primary endpoint–free survival (p = 0.015) compared to the others. In summary, our study highlighted that short (≤ 1 month)–DAPT regimen after LAAO is associated with better outcomes, mainly driven by reduction of major bleedings. Strong evidences arising from randomized trials are warranted to support these findings.

Background Cardiac arrest secondary to a spontaneous coronary artery dissection (SCAD) represents a challenging scenario. It deserves specific considerations due to the dramatic presentation and the need for secondary sudden cardiac death prevention. Methods We collected clinical data of four women admitted during the last two years in the Coronary Care Unit of Parma University Hospital, whose presentation of SCAD were cardiac arrest due to ventricular fibrillation (Table1). Results Three patients survived the acute phases. One patient, being considered at high risk of SCAD recurrence, received a subcutaneous implantable cardioverter–defibrillator (S–ICD). Acute management of cardiac arrest related to SCAD deserves specific considerations. Our case series illustrates the importance of prompt resuscitation manoeuvres and early defibrillation. We propose a flow chart of management of cardiac arrest in patient with suspect of SCAD (Figure 2 A). Evaluating risk of SCAD recurrence and sudden cardiac death. The management of SCAD patients complicated by malignant ventricular arrhythmias and cardiac arrest is challenging. Looking at published registries, it appears that SCAD patients are more likely to suffer from ventricular arrythmia or sudden cardiac death than non–SCAD MI patients. The risk–benefit ratio of ICD implantation in these patients remain uncertain . Evaluation of scar burden with CMR can help stratify the global arrhythmic risk, especially as extensive myocardial scar with a residual impaired LVEF increases the risk of future arrhythmic events (Figure 2 B). In our series, only one patient underwent S–ICD implantation, and the decision was mainly driven by the finding of underlying arteriopathy affecting other vascular territories, suggesting a potentially higher rate of SCAD recurrence. For this particular subset of patients, we propose an algorithm that combines predisposing factors and myocardial injury quantification data (Figure 2 B) that could be useful for the estimate of the risk of malignant arrythmias, as well as the risk of recurrence of SCAD, but needs to be validated in larger case studies. Conclusions The acute management of cardiac arrest related to SCAD deserves specific consideration. The residual myocardial damage, predisposing and precipitants factors should be evaluated in order to estimate the SCAD recurrence and sudden cardiac death risks.

62–year–old male with multiple cardiovascular risk factors.Known pre–capillary porto–pulmonary hypertension treated with Macitentan 10 mg per day, in the context of serum–negative liver disease complicated by portal hypertension and congestive gastropathy.Persistent atrial fibrillation in AVK due to high thromboembolic risk (CHA2DS2VAsc 3).At the last echocardium–TT evidence of worsening of right ventricular systolic function (TAPSE from 20 to 16 mm) and estimated pulmonary hypertension (PAPS from 45 to 65 mmHg). Subsequent hospitalization for severe anemia (Hb 6.5 g/dl), with diagnosis of bleeding angiodysplasias.In consideration of high bleeding risk (HAS–BLED 3), left atrial appendage occlusion has been indicated.The patient underwent right cardiac catheterization, via right femoral vein, with confirmation of severe pulmonary pre–capillary hypertension (mean PAP 45 mmHg, PCWP 14 mmHg); during the same session, left atrial appendage was occluded percutaneously using a Watchman device. At discharge, combination therapy with Riociguat plus Macitentan and single antiplatelet therapy with Clopidogrel 75 mg per day were undertaken. Shortly thereafter, recurrence of gastro–enteric bleeding occurred; after cardiac evaluation, Clopidogrel was discontinued and anticoagulant therapy with Edoxaban 30 mg od was started.The choice of shifting from Clopidogrel to low dose NOAC was guided by the unclear evidence of efficacy and safety of single or dual antiplatelet therapy in a population of patients with both high thrombotic and bleeding risk, such as in this case.Given that NOACs can be considered as an alternative to Warfarin after Watchman implantation (class IIB), after the second recurrence of bleeding, we opted for long–term antithrombotic strategy using a direct oral anticoagulant at reduced dose, making bleeding risk more acceptable instead of the administration of full dosage of NOAC, matter of major importance in candidates for left appendage closure, in whom long–term anticoagulant therapy itself is contraindicated; on the other hand, aiming for a better protection against thromboembolic events compared to standard antiplatelet therapy.

The etiology of spontaneous coronary dissection (SCAD) is not well defined and Non traditional risk factors (NT–RF) have assumed increasing interest, but few data are available. NT–RF include three categories: Sex–related (SR–NT–FR), Sex–predominant (SP–NT–RF) and Gender–related (GR–NT–RF). (Table 1) Aim of the Study The objective of our analysis was to evaluate the incidence of NT–RF in Parma SCAD registry population. Material and methods We reviewed 62 patients with SCAD enrolled between January 2013 through November 2021 Results Traditional risk factors were less common: hypertension was the most prevalent (39 pts, 62.9%). When considering NT–RF, 51 patients (82%) had at least one of all, with at least one SR–RF (66%) or GR–RF (64,5%). Patients with NT–RF were younger at time of SCAD (mean age 53 vs 66; p = 0.027) and they were predominantly females (48 vs 7 pts, p = 0.004) (Table 2). No differences were found among NT–RF SCAD and nNT–RF SCAD patients by fibromuscular dysplasia, peripheral arterial disease and chronic kidney disease. Patients with SCAD more often presented with non ST–segment elevation myocardial infarction (43 pts, 72.6%) vs ST–segment elevation (17 pts, 27.4%). No differences in clinical presentation and angiographic characteristics were found among NT–RF and nNT–RF patients group. MACE occurred in 17.7% of patients of the overall study population, at a median follow–up of 23 (interquartile range: 11;57) months. When comparing the incidence of cardiovascular events in the 2 study groups there was a trend toward a higher prevalence of MACE in NT–RF group without statistical significance (NT–RF SCAD 19.6% – nNT–RF SCAD 9.1%; p = 0.4). (Table 3) Conclusion SCAD is an emerging cause of myocardial infarction in young and middle–aged women without the traditional cardiovascular risk profile. Although overall survival seems good, SCAD is a potentially malignant disease which can present with ventricular arrhythmias and sudden cardiac death. Risk estimation is difficult in women, due to the scarce validity of prediction models, therefore a great effort must be made by the clinical community for the widespread diffusion and use of models incorporating NT–RF. Acknowledgement of peculiar features of this disease could help clinicians and researchers to establish targeted interventions for cardiovascular primary prevention, early diagnosis and secondary prevention in women, including rehabilitation and stress management programmes.

In this paper we continue our derivation of the correlation functions of open quantum spin 1/2 chains with unparallel magnetic fields on the edges; this time for the more involved case of the XXZ spin 1/2 chains. We develop our study in the framework of the quantum Separation of Variables (SoV), which gives us both the complete spectrum characterization and simple scalar product formulae for separate states, including transfer matrix eigenstates. Here, we leave the boundary magnetic field in the first site of the chain completely arbitrary, and we fix the boundary field in the last site $N$ of the chain to be a specific value along the $z$-direction. This is a natural first choice for the unparallel boundary magnetic fields. We prove that under these special boundary conditions, on the one side, we have a simple enough complete spectrum description in terms of homogeneous Baxter like $TQ$-equation. On the other side, we prove a simple enough description of the action of a basis of local operators on transfer matrix eigenstates as linear combinations of separate states. Thanks to these results, we achieve our main goal to derive correlation functions for a set of local operators both for the finite and half-infinite chains, with multiple integral formulae in this last case., 73 pages

Background Coronary provocative test with acetylcholine (ACh) is of utmost importance and increasingly used in patients with myocardial ischemia and non-obstructive coronary arteries. However, data on safety, predictors and prognostic role of complications during intracoronary provocative testing are scarce. Purpose We assessed the safety of ACh provocative test in patients with myocardial ischemia and non-obstructive coronary arteries. Moreover, we evaluated the predictors and the prognostic implications of complications occurring during the provocative test. Methods We prospectively enrolled consecutive patients undergoing intracoronary ACh provocative test for suspected myocardial ischaemia with angiographic evidence of non-obstructive coronary arteries. Complications during the ACh test were collected. Occurrence of major adverse cardiac events (MACE), arrhythmic events at 24-hours ECG dynamic Holter monitoring and angina status were assessed at follow-up. Results We enrolled 310 patients (mean age 60.6±11.9; 169 [54.5%] chronic coronary syndromes [CCS] and 141 [45.5%] with myocardial infarction and non-obstructive coronary arteries [MINOCA]). The overall incidence of complications was low (9%) with a similar incidence in MINOCA and CCS (10 [7.1%] vs 18 [10.7%], p=0.276, respectively). At multivariate logistic regression analysis, a previous history of paroxysmal atrial fibrillation (Odds Ratio [OR] 12.324, Confidence Interval [CI] 95% [4.641; 32.722], p=0.015) and moderate/severe diastolic dysfunction (OR 3.827, CI95% [1.296; 11.304], p=0.015) were independent predictors for occurrence of complications. The occurrence of complications was not associated with a worse clinical outcome at follow-up (median follow-up 22 months) in terms of both MACE, arrhythmic events and angina burden. Conclusion Intracoronary provocative testing with ACh test is safe in patients with myocardial ischemia and non-obstructive coronary arteries, without differences between MINOCA and CCS. History of paroxysmal atrial fibrillation and moderate/severe diastolic dysfunction predicted the occurrence of complications during ACh test. Of importance, our data can reassure clinicians, as the occurrence of complications did not portend a worse prognosis at follow-up in terms of MACE, arrhythmic events and angina burden. Funding Acknowledgement Type of funding sources: None. Complications and clinical presentationClinical outcome at follow-up

Background Air pollution is an emerging key player in determining the residual risk of coronary events. However, pathophysiological mechanisms linking air pollution and coronary events have been not adequately investigated. Purpose We assessed the relationship between exposure to air pollutants and mechanisms of coronary instability evaluated by optical coherence tomography (OCT) in patients with acute coronary syndrome (ACS). Methods ACS patients undergoing OCT imaging were retrospectively selected. Mechanism of culprit lesion instability was classified as plaque rupture (PR) or intact fibrous cap (IFC) by OCT, and the presence of macrophage infiltrates (MØI) and thin-cap fibroatheroma (TCFA) at the culprit site was also assessed. Based on each case's home address, exposure to several pollutants was evaluated, including particulate matter 2.5 (PM2.5), particulate matter 10 (PM10), and carbon monoxide (CO). Only patients with >2 years of available data on air pollution exposure prior to ACS were enrolled. Results We included 136 patients [median age 67.0 years (56.2–76.0), 104 (76.5%) male]. Sixty-six patients (48.5%) had PR as mechanism of plaque instability. Patients with PR were exposed to significantly higher PM2.5 levels compared to IFC, and PM2.5 was an independent predictor for PR (OR=1.133, 95% CI [1.020–1.258], p=0.019). Moreover, exposure to higher levels of PM2.5, PM10 and CO was an independent predictor for the presence of TCFA, while PM2.5 and CO levels predicted the presence of MØI. Interestingly, PM2.5, PM10 and CO levels were positively and significantly correlated with serum levels of C-reactive protein. ROC curves were constructed to assess the ability of PM2.5 to predict the presence of plaque rupture, TCFA or MØI. The AUC for PM2.5 to predict plaque rupture was 0.62 (95% CI: 0.52–0.71, p=0.018), for TCFA was 0.71 (95% CI: 0.61–0.80, p Conclusions We provide novel insights into the missing link between air pollution and increased risk of coronary events. In particular, exposure to higher concentrations of air pollutants is a risk factor for vulnerable plaque features and for plaque rupture as mechanism of coronary instability mediated by systemic and local plaque inflammation. Of importance, the thresholds of air pollutants that predicted the presence of vulnerable plaque features are far lower than commonly accepted safety thresholds used to start preventive measures for public health, suggesting that further efforts are needed in order to reduce the adverse effects on the cardiovascular system. Funding Acknowledgement Type of funding sources: None. Air pollutants exposure and OCT featuresROC curve analysis

Background Coronary microvascular obstruction (MVO) is a noxious condition frequently occurring in patients with ST-elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). However, multiple mechanisms are involved in the pathogenesis of MVO and not yet fully understood. Recent studies suggested that perilipin 2 (PLIN2) may play an important role in lipid metabolism of macrophages resident in atherosclerotic plaques along with a role in enhancing oxidative stress. Purpose To study the association between PLIN2 and MVO in STEMI patients undergoing primary PCI. We also assessed the role of PLIN2 to predict future major cardiovascular events (MACEs). Methods STEMI patients undergoing primary PCI were enrolled. PLIN2 was dosed within 24 hours from admission in peripheral blood monocytes. MVO was assessed using TIMI flow grade and myocardial blush grade on coronary angiogram after PCI, and patients were stratified accordingly (MVO or noMVO). Major adverse cardiac events (defined as a composite of cardiac death, non-fatal myocardial infarction, re-admission for heart failure and target vessel revascularization) were assessed at clinical follow-up. Results Among 100 STEMI patients (mean age, 65.2±12.0 years, 81 males), 33 (33.0%) had MVO. Patients with MVO were older, had higher troponin I peak, C-reactive protein and lower left ventricular ejection fraction on admission. Patients with MVO had significantly higher levels of PLIN2 (1.03±0.28 vs. 0.90±0.16, p=0.019) compared to noMVO patients. Age [OR (95% CI) per year, 1.045 (1.005–1.087), p=0.026] and PLIN2 [OR (95% CI) per unit, 16.606 (2.027–136.030), p=0.009] were associated with MVO at univariate logistic regression analysis. However, only PLIN2 levels [OR (95% CI) per unit, 12.325 (1.446–105.039), p=0.033] were independently associated with MVO at multivariate analysis. Follow up data were available for 76 patients (76%). After a mean follow up of 182.2±126.6 days, 13 MACEs occurred. Patients with MVO had more MACEs [9 (37.5%) vs. 4 (7.7%), p Conclusions In STEMI patients undergoing primary PCI, PLIN2 was independently associated with MVO. PLIN2 was an independent predictor of MACEs at clinical follow-up. These findings suggest that PLIN2 may represent a promising therapeutic target, opening the avenue towards novel therapeutic approaches for MVO. Funding Acknowledgement Type of funding source: None

Background Ticagrelor is a reversibly binding, direct-acting, oral, P2Y12 antagonist used for the prevention of atherothrombotic events in patients with coronary artery disease (CAD). Ticagrelor blocks adenosine reuptake through the inhibition of equilibrative nucleoside transporter 1 (ENT-1) on erythrocytes and platelets, thereby facilitating adenosine-induced physiological responses such as an increase in coronary blood flow velocity. Meanwhile, adenosine plays an important role in triggering ischemic preconditioning through the activation of the A1 receptor. Therefore, an increase in ticagrelor-enhanced adenosine bioavailability may confer beneficial effects through mechanisms related to preconditioning activation and improvement of coronary microvascular dysfunction. Methods To determine whether ticagrelor can trigger ischemic preconditioning and influence microvascular function, we designed this prospective, open-label, pilot study that enrolled patients with stable multivessel CAD requiring staged, fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI). Participants will be randomized in 1:1 ratios either to ticagrelor (loading dose (LD) 180 mg, maintenance dose (MD) 90 mg bid) or to clopidogrel (LD 600 mg, MD 75 mg) from 3 to 1 days before the scheduled PCI. The PCI operators will be blinded to the randomization arm. The primary endpoint is the delta (difference) between ST segment elevations (in millimeters, mm) as assessed by intracoronary electrocardiogram (ECG) during the two-step sequential coronary balloon inflation in the culprit vessel. Secondary endpoints are 1) changes in coronary flow reserve (CFR), index of microvascular resistance (IMR), and FFR measured in the culprit vessel and reference vessel at the end of PCI, and 2) angina score during inflations. This study started in 2018 with the aim of enrolling 100 patients. Based on the rate of negative FFR up to 30% and a drop-out rate up to 10%, we expect to detect an absolute difference of 4 mm among the study arms in the mean change of ST elevation following repeated balloon inflations. All study procedures were reviewed and approved by the Ethical Committee of the Catholic University of Sacred Heart. Discussion Ticagrelor might improve ischemia tolerance and microvascular function compared to clopidogrel, and these effects might translate to better long-term clinical outcomes. Trial registration EudraCT No. 2016–004746-28. No. NCT02701140. Trial status Information provided in this manuscript refers to the definitive version (n. 3.0) of the study protocol, dated 31 October 2017, and includes all protocol amendments. Recruitment started on 18 September 2018 and is currently ongoing. The enrollment is expected to be completed by the end of 2019. Trial sponsor Fondazione Policlinico Universitario A. Gemelli – Roma, Polo di Scienze Cardiovascolari e Toraciche, Largo Agostino Gemelli 8, 00168 Rome, Italy.

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Additional file 1. Details related to main pharmacological interactions and adverse events definition and reporting are provided in the additional file, enclosed in the manuscript.

In this paper we apply our new separation of variables approach to completely characterize the transfer matrix spectrum for quantum integrable lattice models associated to fundamental evaluation representations of $\mathcal{U}_{q} (\widehat{gl_{n}})$ with general quasi-periodic boundary conditions. We consider here the case of generic deformations associated to a parameter $q$ which is not a root of unity. The Separation of Variables (SoV) basis for the transfer matrix spectral problem is generated by using the action of the transfer matrix itself on a generic co-vector of the Hilbert space, following the general procedure described in our paper [1]. Such a SoV construction allows to prove that for general values of the parameters defining the model the transfer matrix is diagonalizable and with simple spectrum for any twist matrix which is also diagonalizable with simple spectrum. Then, using together the knowledge of such a SoV basis and of the fusion relations satisfied by the hierarchy of transfer matrices, we derive a complete characterization of the transfer matrix eigenvalues and eigenvectors as solutions of a system of polynomial equations of order $n+1$. Moreover, we show that such a SoV discrete spectrum characterization is equivalently reformulated in terms of a finite difference functional equation, the quantum spectral curve equation, under a proper choice of the set of its solutions. A construction of the associated Q-operator induced by our SoV approach is also presented., 39 pages

The conclusions of studies of plaque composition in diabetic patients are contradictory [(1–3)][1]. Most studies conducted using imaging modalities have shown a stable pattern of atherosclerosis with more calcific components and less lipid content [(1,2)][1]. Likewise, the pathophysiology of acute

Post-procedural renal microvascular perfusion measured using the Quantitative Blush Evaluator (QuBE) predicts improvement in renal function in patients undergoing percutaneous renal artery stenting Carlo Trani , Italo Porto ⁎, Francesco Burzotta , Giovanni Luigi De Maria , Antonio Maria Leone , Gianpaolo Niccoli , Mario Attilio Mazzari , Rocco Mongiardo , Leonardo Bolognese , Giovanni Schiavoni , Filippo Crea a

We derive compact multiple integral formulas for several physical spin correlation functions in the semi-infinite XXZ chain with a longitudinal boundary magnetic field. Our formulas follow from several effective re-summations of the multiple integral representation for the elementary blocks obtained in our previous article (I). In the free fermion point we compute the local magnetization as well as the density of energy profiles. These quantities, in addition to their bulk behavior, exhibit Friedel type oscillations induced by the boundary; their amplitudes depend on the boundary magnetic field and decay algebraically in terms of the distance to the boundary., 38 pages

ST-elevation myocardial infarction is due to the occlusion of a coronary artery, mainly due to a rupture of an atherosclerotic plaque with superimposed thrombosis. The main therapeutic goal is to restore the blood flow within the culprit artery as quickly as possible. In this review we discussed the several approaches which have been employed to reach this target. Primary percutaneous coronary intervention (PCI) is considered the best treatment option, as it is associated to lower in-hospital mortality, reduced risk of reinfarction and stroke, lower rate of intracranial bleeding and ventricular rupture from myocardial hemorrhage compared with fibrinolytic therapy. Also, it is superior to facilitated PCI, i.e. immediate planned PCI after i.v. thrombolytic therapy administration, because of lower mortality, reinfarction rate, strokes and bleedings. Rescue PCI after failed thrombolysis was associated with a reduction of early severe heart failure and improved survival at 1 year, in patients with moderate to large infarctions, compared to conservative medical therapy, in a pooled analysis of 9 randomized trials, carried out in the balloon era. Also in the stent era, a meta-analysis of 5 randomized trials found a significant 36% reduction in the risk of 30-day mortality, a trend to lower risk of heart failure, although a marginally increased risk of thromboembolic stroke, in the rescue PCI arm. However, rescue PCI is not associated with a better long-term clinical outcome. Laser thrombectomy before PCI could be a useful additional strategy which might be compared to standard stenting in future randomized studies.

We report the case of a 65-year-old woman who developed unstable angina 2 months after successful coronary angioplasty of the left anterior descending coronary artery. Coronary angiography failed to show angiographic restenosis, but intracoronary ergonovine caused ST segment elevation and her habitual chest pain in the absence of epicardial coronary spasm and important pressure changes in the distal left anterior descending coronary artery assessed by a pressure wire, thus suggesting that distal vessel constriction was responsible for unstable angina.

A 61 year old man was admitted to our department suffering from prolonged chest pain at rest complicated by syncope. He reported frequent episodes of typical chest pain mainly in the early morning with preserved effort tolerance. ECG recorded during chest pain revealed transient ST elevation in leads V2–V5. …