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1. Totally laparoscopic right colectomy with complete mesocolon excision

Author

V. Alagna, A. Lucchi, C. Gabbianelli, G. Corbucci Vitolo, P. Berti, G. Garulli, M. Guerra, and F. Vandi

Subjects
03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, Oncology, business.industry, 030220 oncology & carcinogenesis, Right Colectomy, medicine, 030211 gastroenterology & hepatology, Surgery, General Medicine, business
Published
2018
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2. Posters * Safety & Quality (I.E. Guidelines, Multiple Pregnancy, Outcome, Follow-Up etc.)

Author

P. Ocal, S. Sahmay, T. Irez, H. Senol, I. Cepni, S. Purisa, W. Lin, X. Liu, A. Donjacour, E. Maltepe, P. Rinaudo, M. N. Baumgarten, D. Stoop, P. Haentjes, G. Verheyen, F. De Schrijver, I. Liebaers, M. Camus, M. Bonduelle, P. Devroey, E. C. M. Nelissen, A. P. A. Van Montfoort, E. Coonen, J. G. Derhaag, J. L. H. Evers, J. C. M. Dumoulin, J. R. Costa Lopes, J. Mendes dos Santos, S. Portugal Silva Lima, S. Portugal Silva Souza, T. Rodrigues Pereira, J. P. Barguil Brasileiro, H. Pina, M. L. Lessa, M. Genovese Soares, V. Medina Lopes, C. G. Ribeiro, K. Adami, C. Hughes, G. Emerson, K. Grundy, P. Kelly, E. Mocanu, T. Coelho Cafe, J. B. M. de Souza Costa, N. I. Zavattiero Tierno, S. Singh, S. Vitthala, A. Zosmer, L. Sabatini, A. Tozer, C. Davis, T. Al-Shawaf, Q. V. Neri, D. Monahan, Z. Rosenwaks, G. D. Palermo, E. Kalu, M. Y. Thum, H. A. Abdalla, A. Sazonova, C. Bergh, K. Kallen, A. Thurin-Kjellberg, U. B. Wennerholm, G. Griesinger, K. Doody, H. Witjes, B. Mannaerts, B. Tarlatzis, L. Rombauts, E. Heijnen, M. Marintcheva-Petrova, J. Elbers, A. Koning, M. A. Q. Mutsaerts, A. Hoek, B. W. Mol, R. Fadini, T. Guarnieri, M. Mignini Renzini, R. Comi, M. Mastrolilli, A. Villa, E. Colpi, G. Coticchio, M. Dal Canto, M. Dolleman, S. L. Broer, B. C. Opmeer, B. C. Fauser, F. J. M. Broekmans, P. Alama, A. Requena, J. Crespo, M. Munoz, A. Ballesteros, E. Munoz, M. Fernandez, M. Meseguer, J. A. Garcia-Velasco, A. Pellicer, M. Munk, S. Smidt-Jensen, J. Blaabjerg, C. Christoffersen, S. Lenz, S. Lindenberg, E. Bosch, E. Labarta, F. Cruz, C. Simon, J. Remohi, J. Esler, J. Osborn, C. Boissonnas Chalas, A. Marszalek, P. Fauque, J. P. Wolf, D. De Ziegler, L. Cabanes, P. Jouannet, A. R. Han, C. W. Park, S. W. Cha, H. O. Kim, K. M. Yang, J. Y. Kim, I. O. Song, M. K. Koong, I. S. Kang, R. Roszaman, M. H. Omar, Y. Nazri, Y. W. Azantee, A. Z. Murad, M. R. Zainulrashid, N. Wang, F. Le, L. Y. Wang, G. L. Ding, J. Z. Sheng, H. F. Huang, F. Jin, S. Reinblatt, H. Holzer, W. Y. Son, E. Shalom-Paz, R. C. Chian, W. Buckett, M. Dahan, E. Demirtas, S. L. Tan, A. Revel, Y. Schejter-Dinur, S. Revel-Vilk, R. P. M. G. Hermens, E. van den Boogaard, N. J. Leschot, J. H. A. Vollebergh, R. Bernardus, J. A. M. Kremer, F. van der Veen, M. Goddijn, M. J. Nahuis, N. Kose, N. Bayram, P. G. A. Hompes, B. W. J. Mol, F. van der veen, M. van Wely, J. Van Disseldorp, M. D. Dolleman, K. Broeze, M. De Rycke, L. Petrussa, H. Van de Velde, M. Cerrillo, A. Pacheco, S. Rodriguez, R. Gomez, F. Delagado, J. A. Garcia Velasco, S. Desmyttere, W. Verpoest, C. Staessen, A. De Vos, G. Kohls, F. J. Ruiz, G. De la Fuente, M. Toribio, M. Martinez, V. Soderstrom - Anttila, M. Salevaara, A. M. Suikkari, E. Clua, R. Tur, N. Alcaniz, M. Boada, I. Rodriguez, P. N. Barri, A. Veiga, W. L. D. M. Nelen, I. W. H. Van Empel, B. J. Cohlen, J. S. Laven, J. W. M. Aarts, E. Ricciarelli, J. L. Gomez-Palomares, L. Andres-Criado, E. R. Hernandez, B. Courbiere, M. Aye, J. Perrin, C. Di Giorgio, M. De Meo, A. Botta, J. Castilla Alcala, F. Luceno Maestre, Y. Cabello, J. Hernandez, J. Marqueta, A. Pareja, E. Hernandez, B. Coroleu, L. Helmgaard, B. M. Klein, J. C. Arce, I. W. H. van Empel, J. Boivin, C. M. Verhaak, G. Ding, R. Yin, J. Sheng, H. Huang, F. Mancini, M. J. Gomez, N. M. van den Boogaard, J. W. van der Steeg, P. Hompes, P. Boyer, M. Gervoise-Boyer, L. Meddeb, B. Rossin, F. Audibert, S. Sakian, E. Chan Wong, S. Ma, R. Pathak, M. D. Mustafa, R. S. Ahmed, A. K. Tripathi, K. Guleria, B. D. Banerjee, G. Vela, M. Luna, E. D. Flisser, B. Sandler, M. Brodman, L. Grunfeld, A. B. Copperman, M. Baronio, P. Carrascosa, C. Capunay, J. Vallejos, S. Papier, M. Borghi, C. Sueldo, J. Carrascosa, E. Martin Lopez, A. Marcucci, I. Marcucci, P. Salacone, A. Sebastianelli, L. Caponecchia, N. Pacini, R. Rago, M. Alvarez, O. Carreras, M. Arnoldi, D. Diaferia, M. G. Corbucci, L. De Lauretis, M. J. Kook, J. Y. Jung, J. H. Lee, Y. J. Jung, H. K. Hwang, A. Kang, S. J. An, H. M. Kim, H. C. Kwon, S. J. Lee, M. Satoh, J. Imada, K. Ito, F. Migishima, T. Inoue, Y. Ohnishi, H. Kawato, Y. Nakaoka, A. Fukuda, Y. Morimoto, S. Mourad, R. P. T. M. Grol, N. P. Polyzos, A. Valachis, E. Patavoukas, E. G. Papanikolaou, I. E. Messinis, B. C. Tarlatzis, H. Kang, C. H. Kim, E. Park, S. Kim, H. D. Chae, B. M. Kang, K. S. Jung, H. J. Song, Y. S. Ahn, L. Petkova, I. Canov, T. Milachich, A. Shterev, C. Patrat, K. Pocate, J. C. Juillard, V. Gayet, V. Blanchet, D. de Ziegler, J. W. van der, E. Leushuis, P. Steures, C. Koks, J. Oosterhuis, P. Bourdrez, and P. M. Bossuyt

Subjects
Gynecology, medicine.medical_specialty, business.industry, media_common.quotation_subject, Rehabilitation, Viral screening, Obstetrics and Gynecology, Reproductive Medicine, Oocyte Collection, medicine, Quality (business), Intensive care medicine, business, media_common
Published
2010
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6. A Method to Calculate Tissue Impedance Through a Standard Bipolar Pacing Lead

Author

E. Manfredini, G.C. Bini, E. Pardini, G. Corbucci, M. Pauletti, and L. Paperini

Subjects
Pacemaker, Artificial, Transplantation, medicine.medical_specialty, Materials science, Defibrillation, medicine.medical_treatment, General Medicine, Models, Theoretical, Impulse (physics), Electrodes, Implanted, High impedance, Electromagnetic coil, Internal medicine, Electrode, Electric Impedance, medicine, Cardiology, Equivalent circuit, Surgery, Cardiology and Cardiovascular Medicine, Electrical impedance, Tissue impedance, Biomedical engineering
Abstract

The transthoracic impedance (T) and its variations may be estimated through the measurement of the electrical impedance between the can and the right ventricular coil of a defibrillation lead. This method may allow the monitoring of fluid overload before a heart failure attack. Aim of this study was to validate in vitro a method to calculate T in case of a standard bipolar pacing lead, by performing 3 measurements: standard unipolar impedance from the tip (Zuni-tip); unipolar impedance from the ring (Zuni-ring); standard bipolar impedance (Zbip). The formula we used is derived from the standard equivalent circuit of a pacing system: $$\hbox{T} = (\hbox{Zuni-tip}-\hbox{Zbip}+\hbox{Zuni-ring})/2$$ T represents the tissue impedance between the can and the electrodes of the lead. To validate the method we used a saline solution and 3 different pacing leads manufactured by Vitatron (Vitatron BV, Arnhem, The Netherlands): Impulse II (high impedance lead), Crystalline ActFix (screw-in lead), Brilliant S+ (VDD single-lead). The measured values of the saline solution impedance were compared to the values calculated through the formula. The calculated impedance of the solution, evaluated through the proposed formula, is reliable independently of the electrode used and highly correlated to the corresponding measured values (R > 0.9). Tissue impedance may be calculated from standard unipolar and bipolar impedance measurements with a standard bipolar pacing lead.

Published
2006
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7. Implantable loop recorders for assessment of syncope: increased diagnostic yield and less adverse outcomes with the latest generation devices

Author

A, Bartoletti, P, Bocconcelli, T, De Santo, A, Ghidini Ottonelli, S, Giuli, R, Massa, C, Svetlich, G, Tarsi, G, Corbucci, F, Tronconi, and E, Vitale

Subjects
Male, Time Factors, Practice Guidelines as Topic, Electrocardiography, Ambulatory, Humans, Arrhythmias, Cardiac, Female, Syncope, Aged, Electrodes, Implanted, Retrospective Studies
Abstract

Aim of the study was to compare the diagnostic yield of implantable loop recorders (ILR) of two successive generations for the assessment of syncope.Data on patients who had undergone ILR implantation for unexplained syncope in four Italian public hospitals were retrospectively acquired from the Medtronic Clinical Service database. After implantation, routine follow-up examinations were performed every 90 days, while urgent examinations were carried out in the event of syncope recurrence.The following findings were regarded as diagnostic: ECG documentation of a syncope recurrence; documentation of any of the arrhythmias listed by the current guidelines as diagnostic findings even if asymptomatic. Between November 2002 and March 2010, 107 patients received an ILR (40 Medtronic Reveal® Plus; 67 Medtronic Reveal® DX/XT) and underwent at least one follow-up examination. Diagnoses were made in 7 (17.5%) and 24 (35.8%) (P=0.043) patients, with a median time of 228 and 65 days, respectively. Three (42.9%) and 21 (87.5%) (P=0.029) diagnoses were based on automatically detected events, while adverse outcomes occurred in 6 and in 1 (P=0.01) patients, respectively.Our results show that the new-generation device offer a higher diagnostic yield, mainly as a result of its improved automatic detection function, and is associated with fewer adverse outcomes.

Published
2013

8. Shock III

Author

D. Siebenlist, W. Gattenlöhner, W. Lingnau, Ch Hörmann, Ch. Putensen, N. Mutz, L. Jacquet, J. C. Jouret, P. Henin, M. Goenen, H. Tohmo, M. Karanko, K. Korpilahti, M. Scheinin, O. Viinamäki, P. Neuvonen, A. Sabatè, R. Sopena, R. Ramòn, E. Barcelò, C. Roqueta, A. Abad, L. Garcia, X. Garcia, P. Plaisance, E. Vicaut, S. Beloucif, D. Payen, L. Pasini, G. Ortalli, C. Sorbara, D. Lagonidis, S. Magder, J. J. Guardiola, X. Sarmiento, S. Alonso, J. Nigond, C. Arich, J. P. Bertinchant, C. Bengler, J. M. Stordeur, I. M. Chandler, K. L. Stein, T. A. Gasior, R. L. Kormos, M. R. Pinsky, M. Fortuna, M. Horvat, K. Szabò, P. Burtin, M. Clavey, P. M. Mertès, B. Levy, N. Bischoff, P. Mathieu, J. P. Villemot, J. P. Haberer, A. El-Banayosy, H. Posival, K. Minami, M. M. Korner, D. Hartmann, R. Korfer, H. Kortke, G. G. Corbucci, B. Pohar, J. Osredkar, S. Kladnik, G. Bellinzona, S. Noli, A. Giordano, S. Zlzzi, M. Maestri, M. Spada, M. Raimondi, F. Albertario, R. V. Dionigi, V. D’Orio, C. Martinez, G. Saad, P. Mendes, R. Marcelle, K. H. Staupach, M. R. Losser, F. Lenfant, B. Teisseire, P. E. Bollaert, P. F. Laterre, G. Audibert, M. Evenepoel, Ph. Lelarge, A. Larcan, Ph. Bauer, L. Nace, M. C. Laprevote-Heully, M. N. Smithies, Tai Hwei Yee, L. Jackson, R. Beale, D. J. Bihari, C. Cisneros Alonso, J. Gutierrez Rodriguez, F. SAnchez Ramirez, J. Prados Varela, P. Arribas Lòpez, A. Martinez de la Gàndara, R. Boiteau, A. Tenaillon, T. Lherm, F. Chamieh, D. Perrin-Gachadoat, M. Burdin, A. M. Masquelier, M. H. Capron, A. Dougnac, M. Andresen, O. Deckers, H. Evenepoel, D. Henin, M. S. Reynaert, C. Müller, S. Probst, V. Lischke, V. Nicovani, G. Hemàndez, L. Bavestrello, L. Castillo, H. Zhang, H. Sparen, M. Benlabed, N. Nuuyen, J. L. Vincent, O. Kunitz, T. Hillermann, P. Glöckner, F. G. Müller, and G. Kalff

Subjects
Critical Care and Intensive Care Medicine
Published
1992
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9. May we improve risk stratification for thromboembolic events by combining CHADS2 score with atrial fibrillation presence and duration? Proceedings 16th World Congress in Cardiac Electrophysiology and Cardiac Techniques

Author

G.L. Botto, L. Padeletti, M. Santini, A. Capucci, M. Gulizia, F. Zolezzi, S. Favale, G. Molon, R. Ricci, B. Mariconti, M. Vimercati, G. Corbucci, BIFFI, MAURO, BORIANI, GIUSEPPE, GL.Botto, L.Padeletti, M.Santini, A.Capucci, M.Gulizia, F.Zolezzi, S.Favale, G.Molon, R.Ricci, M.Biffi, B.Mariconti, M.Vimercati, G.Corbucci, and G.Boriani.

Published
2008

10. May we rely on standard methods fora atrial fibrillation detection?

Author

BORIANI, GIUSEPPE, BIFFI, MAURO, L. Padeletti, M. Santini, A. Capucci, M. Gulizia, F. Zolezzi, S. Favale, G. Molon, R. Ricci, M. Luzi, M. Vimercati, G. Corbucci, G.L. Botto, G.Boriani, L.Padeletti, M.Santini, A.Capucci, M.Gulizia, F.Zolezzi, S.Favale, G.Molon, R.Ricci, M.Biffi, M.Luzi, M.Vimercati, G.Corbucci, and GL.Botto

Subjects
ATRIAL FIBRILLATION
Published
2008

12. From Analog to Digital Technology: What Are the Clinical Benefits?

Author

G. Corbucci and R. Mantovan

Subjects
Cardiovascular event, Reliability (semiconductor), medicine.anatomical_structure, business.industry, Implanted electrodes, Computer science, medicine, Atrium (heart), business, Computer hardware, Blanking, Digital signal processing
Abstract

The advent of digital technology in implantable cardiac stimulators will open up new frontiers for the automatic analysis and diagnosis of endocardial signals. This will dramatically increase the reliability of the therapies delivered and the amount of information that can be processed and stored for clinical and scientific purposes. In the next few years, we can expect specific algorithms to be developed for morphological discrimination of the farfield R-wave in the atrium and the retrograde P-wave. The use of blanking periods will gradually be phased out, since the system will instantly classify what it receives from the implanted electrodes, without needing to mask undesired signals. Such devices w ill really and continuously monitor every cardiac event.

Published
2006
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13. Mechanisms of cell protection by adaptation to chronic and acute hypoxia: molecular biology and clinical practice

Author

G G, Corbucci, A, Marchi, B, Lettieri, and C, Luongo

Subjects
Acute Disease, Chronic Disease, Humans, Adaptation, Physiological, Cell Hypoxia, Cell Physiological Phenomena
Abstract

Several experimental and clinical studies have shown that specific biochemical and molecular pathways are involved in the myocardial and skeletal muscle cell tolerance to acute and/or chronic hypoxic injury. A number of different factors were proposed to play a role in the preservation of tissue viability, but to a few of them a pivotal role in the adaptive mechanisms to hypoxic stimuli could be ascribed. Starting from the observation that mitochondrial electron transport chain (ETC) enzymic complexes are the targets of oxygen reduced availability, most of data are compatible with a mechanism of enzymic adaptation in which the nitric oxide (NO) generation plays the major role. If the partial and reversible NO-induced inhibition of ETC enzymic complexes represents the most rapid and prominent adaptive mechanism in counteracting the damaging effects of hypoxia, the sarcolemmal and mitochondrial K+(ATP) channels activation results to be closely involved in cytoprotection. This process is depending on protein kinase C (PKC) isoform activation triggered by reactive oxygen species (ROS) generation, adenosine triphosphate (ATP) depletion and Ca++ overload. It is well known that all these factors are present in hypoxia-induced oxidative damage and mitochondrial Ca++ altered pools represent powerful stimuli in the damaging processes. The activation of mitochondrial K+(ATP) channels leads to a significant reduction of Ca++ influx and attenuation of mitochondrial Ca++ overload. Closely linked to these adaptive changes signal transduction pathways are involved in the nuclear DNA damage and repair mechanisms. On this context, an essential role is played by the hypoxia-induced factor-1alpha (HIF-1alpha) in terms of key transcription factor involved in oxygen-dependent gene regulation. The knowledge of the biochemical and molecular sequences involved in these adaptive processes call for a re-evaluation of the therapeutic approach to hypoxia-induced pathologies. On this light, some specific aspects of the therapeutic management of critically ill patients are taken into consideration and discussed in relation to the cellular biodynamics.

Published
2005

14. Deep sedation for magnetic resonance imaging. Personal experience

Author

A, Marchi, A, Orrù, M E, Manai, C, Chelo, B, Lettieri, and G G, Corbucci

Subjects
Male, Child, Preschool, Conscious Sedation, Humans, Female, Chloral Hydrate, Magnetic Resonance Imaging, Propofol
Abstract

Precision in diagnostic procedure and examination of paediatric patients often requires their absolute immobility. Deep sedation has proven to be an excellent method, allowing optimum technical quality of MRI particularly in younger age groups. The aim of study is to demonstrate the possible application of deep sedation through the use of 2 safe and manageable drugs.We carefully evaluated and selected 82 patients (47 males and 35 females; average age 5.4 years): they came from various paediatrics departments. Deep sedation was practiced with: Chloral hydrate (60-80 mg/kg in one oral administration); propofol as intravenous bolus (2-2.5 mg/kg) followed by a maintenance infusion of 75-125 microg/kg/min. This was preceded by midazolam (0.05 mg/kg i.v.) outside the MRI room. Oxygen saturation (SpO2) was monitored in all patients along with heart rate in order to foresee the need for any possible therapeutic intervention.The sedation levels attained permitted the success of MRI assuring the immobilization required. Manually assisted mask ventilation was required for a period of 2-3 min in 5 patients treated with propofol. All other patients breathed autonomously. Complete reawakening occurred within 2 hours of drug administration. Surveillance was prolonged inside their respective units, however, without registering delayed side effects.The central point of the success of deep sedation is to define the type and dose of optimum drug for individual patients. This requires a qualified, expert group ready to intervene in the presence of adverse results of drugs administered. Propofol and chloral hydrate are the optimum drugs for diagnostic techniques requiring total immobilization and rapid reawakening.

Published
2004

15. Cardiac Resynchronization Therapy: What Device Data Do We Need for Optimal Patient Treatment?

Author

M. Marconi, S. Sermasi, M. Mezzetti, G. Corbucci, and Giancarlo Piovaccari

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Continuous monitoring, Cardiac resynchronization therapy, Hemodynamics, Atrial fibrillation, medicine.disease, Pressure sensor, medicine.anatomical_structure, Ventricle, Internal medicine, Heart failure, Cardiology, medicine, Heart rate variability, business
Abstract

The long experience of rate-responsive (RR) pacing and the technological advances in implantable devices form the basis for significant improvement of diagnostics for the treatment of atrial fibrillation (AF) or heart failure (HF) or both. In the past, the development of sensors for RR pacing gave the chance to investigate not only the effectiveness of physiological and mechanical sensors, but also long-term reliability and stability. Many sensors failed to demonstrate their long-term reliability and stability after implantation. For example, pressure sensors implanted in the right ventricle (RV) were totally surrounded by fibrosis after some months, making their membrane unreliable in detecting the true pressure. Similar problems were reported for oxygen saturation and pH sensors. Recently, pressure sensors for the RV have been proposed again for continuous monitoring of the hemodynamics of patients with HF: probably improvements in their technology have increased their long-term reliability. The strong competition for RR pacing in clinical practice has left in the market only the stable and reliable ones.

Published
2004
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16. Rate Control of Atrial Fibrillation: By How Much Should the Ventricular Rate be Lowered?

Author

L. Gianfranchi, G. Corbucci, P. Alboni, G. Fucà, and F. Pacchioni

Subjects
medicine.medical_specialty, education.field_of_study, Heart disease, business.industry, Population, Cardiomyopathy, Atrial fibrillation, medicine.disease, Internal medicine, Heart failure, Heart rate, medicine, Cardiology, Sinus rhythm, Myocardial infarction, education, business
Abstract

Heart rate (HR) should be neither too high, since it can be responsible for tachycardia-induced cardiomyopathy [1, 2], nor too low, since it can facilitate the appearance of heart failure, at least in old people with heart disease [3,4], Moreover, mounting evidence shows that an elevated resting sinus rate is a predictor of cardiovascular morbidity and mortality. In fact, in multivariate analysis, a high sinus rate emerged as an independent predictor of mortality in the general population [5], in elderly subjects [6], and in selected groups of patients with hypertension [7] or myocardial infarction [8]. At present the prognostic value of resting HR in patients with chronic atrial fibrillation (AF) is unknown; however, it should be expected to be the same.

Published
2004
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18. [Percutaneous cervical cordotomy in the therapy of incidence pain]

Author

S, Mameli, L, Frau, A, Orrù, A, Marchi, and G G, Corbucci

Subjects
Adult, Aged, 80 and over, Male, Cordotomy, Humans, Pain, Female, Middle Aged, Neck, Aged, Retrospective Studies
Abstract

Incident pain does not respond to opioid treatment and it is not easily relieved with other therapeutic strategies (local intrapleural or spinal analgesia, phenol blocks etc.). For this reason cervical percutaneous cordotomy at C(1)-C(2) interspace is the only effective antalgic therapy in patients whose life expectancy is more than three to six months.This study is a rectrospective review of 22 patients with cancer and incident pain from brachial, lumbar-sacral plexus injury and gluteal ulcer.Cordotomy provided excellent contralateral side pain relief in 21 patients; pain relief was maintained up to death and to the moment of last observation in living patients. In one deaf patient it was impossible to carry out the procedure due to incomplete co-operation and pain returned after 48 hours. Ventilatory depression caused death in one patient. Other complications recorded included ataxia, headache, motor deficit, dysesthesia and orthostatic hypotension.The conclusion is drawn that percutaneous cordotomy should, in carefully selected cases, be considered the only technique to relieve incident pain.

Published
2003

19. Middle amplitude range analysis for intracardiac atrial electrograms classification

Author

M. Reggiani, E. Borgo, G. Sartori, G. Corbucci, M. Morando, A. Casaleggio, and P. Rossi

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Atrial fibrillation, medicine.disease, Intracardiac injection, Interval (music), Rhythm, Amplitude, Internal medicine, Cardiology, Medicine, Sinus rhythm, business, Electrocardiography, Atrial flutter
Abstract

This paper analyzes the Middle Amplitude Range (MAR) of Intracardiac Atrial Electrograms. Electrograms are obtained using bipolar catheters from the High Right Atrium during Electrophysiological (EP) studies. Three groups of stable rhythm are considered: atrial fibrillation (AF), atrial flutter (AFL) and sinus rhythm (SR). EP studies are obtained from 10 subjects many of whom presented different rhythms in different intervals of the study. The major purpose of the work is to propose a method, compatible with implementation on implantable devices, able to discriminate among SR, AF and AFL in a defined decision time interval. This aim is achieved by combining the analyses based on cycle length and MAR. The results are presented in terms of sensitivity, specificity and total accuracy for various choices of the decision time interval. The best performances are obtained for a 4 second interval and give a total accuracy of 98.9%, with specificity of 99.2% and average sensitivity of 98.8%.

Published
2003
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20. A new method for fibrillation detection from endocardial electrograms

Author

G. Delfino, M. Reggiani, M. Morando, G. Corbucci, A. Casaleggio, E. Borgo, G. Sartori, and P. Rossi

Subjects
Fibrillation, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Atrial fibrillation, medicine.disease, Rhythm, Duration (music), Internal medicine, Heart rate, Cardiology, Medicine, Chronic atrial fibrillation, Sinus rhythm, medicine.symptom, business, Electrocardiography
Abstract

A new approach is presented for automatic efficient detection of atrial fibrillation not based on heart rate, but on morphologic analysis of the electrogram. Endocardiac signals have been collected from 9 patients (4 of them affected by chronic atrial fibrillation and 5 affected by other disturbances of the rhythm) during human cardiac electrophysiologic (EP) studies using a Manta Mennen Poligraph and cut into short intervals of different duration (from 0.5 to 20 seconds). 1018 seconds of sinus rhythm (SR) and 726 seconds of atrial fibrillation (AF) have been analyzed. Then the authors divided all segments in two separate groups: the training group to define appropriate discrimination threshold and the test group to quantify results. Results for the 4-seconds decision time show 94 and 96 values of 94 The method is straightforward and compatible with implantable devices (easy implementation and real time).

Published
2002
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21. Methods for intracardiac electrogram compression suitable with implantable devices

Author

M. Morando, M. Reggiani, S. Chierchia, G. Sartori, P. Rossi, G. Corbucci, A. Casaleggio, and Michela Chiappalone

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Computer science, Beat detection, Data set, medicine.anatomical_structure, Ventricle, Compression (functional analysis), Internal medicine, mental disorders, Compression ratio, cardiovascular system, medicine, Cardiology, Right atrium, Electrocardiography, Intracardiac Electrogram, Biomedical engineering
Abstract

Studies methods for intracardiac electrogram compression that are suitable for implementation in implantable devices. The algorithms are based on piecewise linear approximation (PLA) methods and beat detection (the peak method). Intracardiac electrograms were obtained, from the right atrium and ventricle, during electrophysiological studies. The total atrial set consists of 5060 s of bipolar recordings and 680 s of unipolar electrograms; the ventricular data set contains 1210 s of bipolar and 480 s of unipolar signals. The peak method clearly performs better than the others to compress bipolar signals, while PLA methods are needed in order to have reliably compressed unipolar data. Performances over the whole bipolar database (including atrial and ventricular sets) reached an average compression ratio (CR) of 7.6, while first-order piecewise linear approximation on unipolar electrograms reached CR=6.6. These preliminary results show that time consumption can be reduced suitably with real-time compression for implantable devices. The ability to compress and store intracardiac electrograms in implantable devices allows detailed verification of appropriate intervention of the device and it might open up new perspectives in the study of the mechanisms involved in the onset of malignant tachyarrhythmias.

Published
2002
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22. Low complexity methods for intracardiac atrial electrogram compression

Author

M. Morando, Michela Chiappalone, M. Reggiani, A. Casaleggio, E. Borgo, G. Corbucci, G. Sartori, and P. Rossi

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Atrial fibrillation, medicine.disease, Compression (physics), Intracardiac injection, Beat detection, Internal medicine, cardiovascular system, medicine, Cardiology, Sinus rhythm, cardiovascular diseases, Electrocardiography, Atrial flutter, Data compression, Mathematics
Abstract

This paper studies methods for intracardiac atrial electrograms compression suitable with implementation on implantable devices. Algorithms are based an piecewise linear approximation, beat detection, and their combination. Bipolar intracardiac electrograms were obtained during electrophysiological studies and divided into 3 rhythm groups. The authors analyzed 2196 seconds of sinus rhythm (SR), 786 sec. of atrial fibrillation (AF) and 1793 sec. of atrial flutter (AFL). Performance over the whole data base reach average compressed data rate (CDR) ranging between 500 and 850 (bits/second), and the percent of root mean square difference (PRD) varies from 2 to 12% depending on the choice of methods and accepted errors. Preliminary results show that time consumption can be reduced to enable real time compression with implanted devices.

Published
2002
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23. Computationally inexpensive methods for intra-cardiac atrial bipolar electrogram compression

Author

M. Reggiani, Michela Chiappalone, P. Rossi, S. Chierchia, G. Corbucci, A. Casaleggio, M. Morando, and G. Sartori

Subjects
Adult, Male, medicine.medical_specialty, Pacemaker, Artificial, Beat (acoustics), Beat detection, Electrocardiography, Microcomputers, Physiology (medical), Internal medicine, Atrial Fibrillation, medicine, Humans, Sinus rhythm, Heart Atria, Intra-cardiac bipolar electrograms, data compression, Aged, Signal processing, medicine.diagnostic_test, business.industry, Atrial fibrillation, Signal Processing, Computer-Assisted, Middle Aged, medicine.disease, Defibrillators, Implantable, Atrial Flutter, pacemakers, Compression ratio, Cardiology, Costs and Cost Analysis, mathematical algorithms, Female, Cardiology and Cardiovascular Medicine, business, Atrial flutter, Algorithms
Abstract

Aim This paper reports studies of mathematical algorithms for intra-cardiac atrial bipolar electrogram compression suitable with implementation on implantable devices. Patients and Methods Bipolar intra-cardiac electrograms (IEGMs) of high right atrium were obtained from 20 patients who underwent electrophysiological studies for arrhythmias. Four thousand seven hundred and eighty-two seconds of IEGM were collected and divided into three rhythm groups: sinus rhythm (SR), atrial fibrillation (AF) and atrial flutter (AFL). Since mathematical algorithms suitable for use with implantable devices demand low computational cost, we employed piecemeal linear approximation methods (ZOP -- Zero Order Prediction and SAPA -- Scan Along Polygonal Approximation), and beat detection method (Peak) both or which need small numbers of operations to perform electrogram compression. Compression ratio (CR) and percent root mean square di ff erence (PRD) were used to compare the three methods, with statistical analyses performed using paired t-test. Results and Conclusion The best performance was obtained using the Peak method which reaches an average CR of 10·6 in the case of SR group, 2·8 for AF, and 3·6 for AFL groups, respectively, while PRD lies below 2% for SR and AFL groups and 6% for the AF group. Results show that, for bipolar electrograms, the Peak method reaches statistically significant better performance (P

Published
2002
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25. Antioxidant property of Propofol in the ischemic and reperfused human skeletal muscle

Author

G G, Corbucci, A, Marchi, C, Velluti, C, Chelo, E, Grella, B, Lettieri, Gian Giacomo, Corbucci, Marchi, Antonio, Velluti, Claudio, Chelo, C, Grella, Elisa, and Lettieri, Biagio

Subjects
Adult, Male, Muscle, skeletal, Reperfusion, injury, Catalase, Antioxidants, Uric Acid, Ischemia, Malondialdehyde, Reperfusion Injury, Humans, Lipid Peroxidation, Propofol, Anesthetics, Intravenous, Propofol, therapeutic use
Abstract

Background. Oxygen-derived free radicals (ROS) are involved in tissue damage during muscle ischemia and reperfusion. Recent in vitro studies have demonstrated that a beneficial effect of Propofol (2,6 diisopropylphenol) lies on its free radical scavenging properties. The current study therefore examined whether Propofol is effective against the peroxidative damage induced by ROS in human skeletal muscle in the course of acute ischemia and reperfusion. Methods. A homogeneous group of patients (n=20) undergoing orthopedic surgery was subjected to handline tourniquet at 350 At for 60 min following by 20 min postischemic reperfusion. In skeletal muscle samples (m. vastus lat.) malondyaldeide (MDA), catalase (CAT) and uric acid levels were analyzed before tourniquet application, after 60 min of ischemia and then after 20 min following reperfusion. To ten subjects Propofol was supplied as bolus (5 mg/kg, body weight) during the ischemic interval. The tissue concentrations of MDA, CAT and Uric Acid were measured by spectrophotometric and phluorimetric methods comparing the values with the data obtained in an untreated group of patients (n = 10). Results. In all patients ischemic injury significantly increased MDA, and Uric Acid contents with a concomitant decrease in CAT levels. When reperfused the Propofol treated group showed an evident decrease in MDA Uric, and CAT gradients in respect of ischemic tissue. On the contrary rapid reoxygenation implies a highly significant increase in MDA as far as Uric Acid contents, while Catalase levels were unchanged. Conclusions. The current study demonstrated that in the human skeletal muscle Propofol attenuates the lipid peroxidation induced by ischemia and reperfusion and this beneficial action of Propofol is probably correlated with the free radical scavenging properties of this molecule.

Published
2002

26. Biomolecular and biochemical response of myocardial cell to ischemia and reperfusion in the course of heart surgery

Author

A, Ricchi, G, Cardu, B, Lettieri, D E, Fusar-Poli, C, Tacchini, A, Bernelli-Zazzera, and G G, Corbucci

Subjects
Myocardial Ischemia, Myocardial Reperfusion, Blotting, Northern, Nitric Oxide, Mitochondria, Heart, Electron Transport Complex IV, RNA, Ribosomal, Malondialdehyde, Humans, Succinate Cytochrome c Oxidoreductase, Coronary Artery Bypass, Oxidation-Reduction, Chromatography, High Pressure Liquid, Heat-Shock Proteins
Abstract

Previous studies have shown that biomolecular and biochemical adaptive changes antagonize oxidative damage due to hypoxia and ischemia in myocardial cells. The aim of our study was to verify in human ischemic and reperfused cardiac tissue the relationship between mitochondrial enzyme activities and the activation of HSP70 and c-fos syntheses in the context of a cytoprotective mechanism. Nitric oxide (NO) modulating effects on mitochondrial respiratory chain enzyme activities in ischemic and reperfused tissue were investigated (preliminary report).During elective coronary artery bypass grafting, in 30 consecutive patients ventricle samples were taken one before aortic clamping the second after 55+/-8 min ischemic period and the third 34+/-5 after final reperfusion. Coronary sinus blood samples were taken in parallel to assess free radical release measured by malonaldehyde (MDA) levels. In a small number of patients (N=5) nitric oxide tissue levels were analyzed.When compared with normoxic tissue, a significant decrease in cytochrome Coxidase (COX) and succinate Cyt-c reductase (SCR) activities in ischemic and reperfused samples were observed. The activation of HSP70-72 and c-fos transcription factor was evident in courses of ischemia and reperfusion. Blood MDA levels underline the concept that oxyradical generation characterize the peroxidative damage in reoxygenated myocardial tissue while adaptive changes which occur in ischemic cells seem to antagonize the oxyradical injury.In the course of heart surgery the myocardial cell seems to prevent ischemic damage by activating some peculiar biomolecular and biochemical adaptive changes which permit the reversibility of the oxidative injury. In contrast it appears evident that massive and rapid reoxygenation of the cardiac tissue leads to peroxidative damage due to oxyradical generation. Nitric oxide seems to play a crucial role in cellular adaptation to ischemia even if further studies will be needed to elucidate these findings. From the data obtained in this work we cannot draw certain conclusions in terms of human cardiac cell adaptation to ischemia whereas it seems convincible that reoxygenation, as actually employed in clinical practice, compromises the integrity of the cells.

Published
2001

27. The nitric oxide metabolism in the hypoxic, ischemic and reperfused human skeletal muscle cell: clinical and therapeutical observations

Author

G G, Corbucci, C, Palmerini, R, Palombari, B, Lettieri, E, Grella, C, Velluti, C, Chelo, Corbucci, Gg, Palmerini, C, Palombari, R, Lettieri, B, Grella, Edoardo, Velluti, C, and Chelo, C.

Subjects
Adult, Male, Ischemia, Regional Blood Flow, Reperfusion, Humans, Female, In Vitro Techniques, Muscle, Skeletal, Nitric Oxide, Cell Hypoxia
Abstract

BACKGROUND: The biochemical and metabolic role played by nitric oxide (NO) in course of oxidative stress due to cell hypoxia, ischemia and reperfusion has a determinant relevance in the mitochondrial adaptive changes which antagonize the irreversible morpho-functional damage. In particular conditions, such as in prolonged ischemia and/or exogenous NO supplementation, this element is present in the radical form (NOO*) concurring to peroxidative cell injury. Aim of this study was to investigate these opposite NO aspects in hypoxic, ischemic and reperfused human skeletal muscle tissue. METHODS: Skeletal muscle samples were taken during elective knee orthopedic surgery in 10 consecutive patients. The biopsies were obtained before, after 5+/-1 min and 58+/-2 min from tourniquet application and then after 18+/-3 min following muscle reperfusion. The samples, immediately frozen in liquid nitrogen, were assayed for endocellular free NO following the gas-amperometric method described by Palmerini C. RESULTS: When compared with normoxic tissues, a significant decrease in free NO content was observed in hypoxic samples. After about 60 min of prolonged ischemia the NO levels show an evident increase, while the tissue reperfusion leads to a progressive restoration of physiological content in the cellular free nitric oxide. CONCLUSIONS: The obtained data in hypoxic muscle cell seem to underline the pivotal role played by NO in adapting the cytochrome c oxidase oxidative activity to lower O2 bio-availability. On the other hand the prolonged ischemia leads to a consistent NOO* generation triggered by oxyradical generation and Ca2+ intracellular over load. Even if the tissue reoxygenation restores the normal NO levels it is arguable that the pre-treatment of ischemic cell with antioxidants, Ca-antagonist and Dexamethasone supplementation could represent a crucial and specific therapeutic approach to critically ill patient.

Published
2001

29. Adaptive changes in response to acute hypoxia, ischemia and reperfusion in human cardiac cell

Author

G G, Corbucci

Subjects
Oxygen Consumption, Malondialdehyde, Myocardium, Reperfusion Injury, Acute Disease, Humans, HSP70 Heat-Shock Proteins, Blotting, Northern, Hypoxia, Adaptation, Physiological, Proto-Oncogene Proteins c-fos, Mitochondria, Heart
Abstract

Previous studies have shown that biomolecular and biochemical adaptive changes antagonize oxidative damage due to hypoxia and ischemia in myocardial cells. The aim of our study was to verify in human ischemic and reperfused cardiac tissue the relationship between mitochondrial enzyme activities and the activation of HSP70 and c-fos synthesis in the context of a cytoprotective mechanism. Nitric oxide (NO) modulating effects on mitochondrial respiratory chain enzyme activities in ischemic and reperfused tissue were investigated (preliminary report).During elective coronary artery bypass grafting, in 30 consecutive patients ventricle samples were taken one before aortic clamping the second after 55 +/- 8 min ischemic period and the third 34 +/- 5 after final reperfusion. Coronary sinus blood samples were taken in parallel to assess free radical release measured by malondialdehyde (MDA) levels. In a small number of patients (N = 5) nitric oxide tissue levels were analyzed.When compared with normoxic tissue, a significant decrease in cytochrome oxidase (COX) and succinate Cyt-c reductase (SCR) activities in ischemic and reperfused samples were observed. The activation of HSP70-72 and c-fos transcription factor was evident in courses of ischemia and reperfusion. Blood MDA levels underline the concept that oxyradical generation characterizes peroxidative damage in reoxygenated myocardial tissue while adaptive changes which occur in ischemic cells seem to antagonize the oxyradical injury.In the course of heart surgery the myocardial cell seems to prevent ischemic damage activating some peculiar biomolecular and biochemical adaptive changes which permit the reversibility of the oxidative injury. In contrast it appears evident that massive and rapid reoxygenation of the cardiac tissue leads to peroxidative damage due to oxyradical generation. Nitric oxide seems to play a crucial role in cellular adaptation to ischemia even if further studies will be needed to elucidate these findings. From the data obtained in this work we cannot draw certain conclusions in terms of human cardiac cell adaptation to ischemia whereas it seems convincing that reoxygenation, as actually employed in clinical practice, compromises the integrity of the cells.

Published
2000

30. Automatic atrial tachyarrhythmia detection from intracardiac electrograms

Author

P, Rossi, A, Casaleggio, M, Morando, G, Corbucci, M, Reggiani, G, Sartori, and E, Borgo

Subjects
Male, Electrocardiography, Pacemaker, Artificial, Atrial Flutter, Atrial Fibrillation, Humans, Female, Algorithms, Defibrillators, Implantable
Abstract

Automatic atrial tachyarrhythmia recognition is crucial in order to allow a correct switching-mode function of dual-chamber pacemakers and to avoid inappropriate shocks of ventricular implantable cardioverter-defibrillators. In this paper we considered three algorithms suitable for implantable devices. The first was based on the atrial cycle length; the others analyze different morphologic characteristics of atrial signals.Intracardiac bipolar electrogram recordings were obtained from the high right atrium during electrophysiological study. Twenty patients were considered, some of them presenting with different types of cardiac rhythm at different intervals of the study. Cardiac rhythms were divided into three groups: sinus rhythm consisting of 2,196 s obtained from 12 subjects, atrial fibrillation consisting of 771 s obtained from 7 subjects, and atrial flutter consisting of 1,793 s obtained from 7 subjects. The automatic detection was performed on each electrogram segment lasting 1 or 4 s. Atrial segments were separated into two subgroups: the first for the training of the algorithm and the second for testing and validation of results. We considered two types of statistical analysis: comparison between pairs of rhythm (paired classification), and classification among the three different groups (direct classification).The combination of the cycle length algorithm with a morphological method achieved the best performance for both statistical analyses. Paired classification resulted in the following: atrial fibrillation vs sinus rhythm was detected with no error; atrial flutter vs sinus rhythm with a total accuracy of 99.3% (sensitivity 99.4%, specificity 99.2%); atrial fibrillation vs atrial flutter with a total accuracy of 99.1% (sensitivity 98.5%, specificity 99.4%). The total accuracy achieved for the direct classification was 98.6% (average sensitivity 98.5%, specificity 98.8%).Our results support the association of algorithms for future enhancement of atrial tachyarrhythmia detection in dual-chamber devices, thanks to the limited computational effort.

Published
2000

32. Biochemical and metabolic aspects of oxyradical pathology in the hypoxic-ischemic reperfused human skeletal muscle tissue. Clinical markers and therapeutic approach

Author

G G, Corbucci, C, Chelo, N, Salvi, C, Velluti, B, Lettieri, E, Grella, Corbucci, Gg, Chelo, C, Salvi, N, Velluti, C, Lettieri, B, and Grella, Elisa

Subjects
Adult, Male, Ischemia, Regional Blood Flow, Reperfusion Injury, Humans, Female, In Vitro Techniques, Hypoxia, Muscle, Skeletal, Reactive Oxygen Species, Biomarkers
Abstract

BACKGROUND: Following our previous studies on the biomolecular and biochemical aspects of the human tissue oxidative damage due to hypoxia, ischemia and reperfusion, aim of the present work is to evaluate the role played by oxyradical generation in the morphofunctional cellular injury. We evaluated the tissue levels of some metabolic markers (MDA, Catalase, Uric Acid) to obtain a pathogenic picture and then a therapeutic approach closely related to the cellular biodynamics. METHODS: A skeletal muscle samples were taken during elective knee orthopedic surgery in 20 consecutive patients. The biopsies were taken in normoxic conditions and after 5 +/- 1 and 62 +/- 3 min form tourniquet application and finally 21 +/- 2 min following muscle reperfusion. The samples were assayed for tissue Malondialdeyade (MDA), uric acid and catalase (CAT) contents with HPLC and fluorimetric procedures. All data were evaluated in terms of computerized statistical analysis. RESULTS: When compared to normoxic tissue (1.24 +/- 0.26 nmoli.mg-1 protein), the MDA levels show a moderate increase in hypoxic (1.66 +/- 0.12) and ischemic tissue (1.78 +/- 0.13), while highly significant is the rise in reperfused muscle MDA content (5.94 +/- 0.15). The uric acid as far as CAT shows no appreciable alterations in hypoxia and ischemia. Following reoxygenation an increase in uric acid contents with a concomitant CAT tissue consumption appear evident. CONCLUSIONS: The obtained data seem to underline the cytoprotective role played by adaptive changes in the hypoxic and ischemic human cells. On the contrary, the rapid reoxygenation of the ischemic tissue appears to start oxyradical neo-generation. In clinical and therapeutic terms these observations underline a peculiar and different approach to the critically ill patient.

Published
2000

33. Exogenous reactive oxygen species deplete the isolated rat heart of antioxidants

Author

J. Vaage, Roberto Alberto DeBlasi, A.G. Semb, M. Bufi, Giacomo G. Corbucci, Øivind Irtun, Alessandro Gasparetto, and Massimo Antonelli

Subjects
Male, Xanthine Oxidase, Oxidative phosphorylation, In Vitro Techniques, Biochemistry, Antioxidants, Mitochondria, Heart, Statistics, Nonparametric, Lipid peroxidation, Superoxide dismutase, Electron Transport, chemistry.chemical_compound, Physiology (medical), Coronary Circulation, Ventricular Pressure, Cytochrome c oxidase, Animals, Rats, Wistar, Xanthine oxidase, chemistry.chemical_classification, Reactive oxygen species, Hypoxanthine, biology, Myocardium, Malondialdehyde, Molecular biology, Glutathione, Myocardial Contraction, Rats, Perfusion, chemistry, Coenzyme Q – cytochrome c reductase, biology.protein, Reactive Oxygen Species
Abstract

The effects of reactive oxygen species (ROS) on myocardial antioxidants and on the activity of oxidative mitochondrial enzymes were investigated in the following groups of isolated, perfused rat hearts. I: After stabilization the hearts freeze clamped in liquid nitrogen ( n = 7). II: Hearts frozen after stabilization and perfusion for 10 min with xanthine oxidase (XO) (25 U/l) and hypoxanthine (HX) (1 mM) as a ROS-producing system ( n = 7). III: Like group II, but recovered for 30 min after perfusion with XO + HX ( n = 9). IV: The hearts were perfused and freeze-clamped as in group III, but without XO + HX ( n = 7). XO + HX reduced left ventricular developed pressure and coronary flow to approximately 50% of the baseline value. Myocardial content of hydrogen peroxide (H 2 O 2 ) and malondialdehyde (MDA) increased at the end of XO + HX perfusion, indicating that generation of ROS and lipid peroxidation occurred. Levels of H 2 O 2 and MDA normalized during recovery. Superoxide dismutase, reduced glutathione and α -tocopherol were all reduced after ROS-induced injury. ROS did not significantly influence the tissue content of coenzyme Q 10 (neither total, oxidized, nor reduced), cytochrome c oxidase, and succinate cytochrome c reductase. The present findings indicate that the reduced contractile function was not correlated to reduced activity of the mitochondrial electron transport chain. ROS depleted the myocardium of antioxidants, leaving the heart more sensitive to the action of oxidative injury. Copyright © 1996 Elsevier Science Inc.

Published
1997

35. Metabolic aspects of cardiac and skeletal muscle tissues in the condition of hypoxia, ischaemia and reperfusion induced by extracorporeal circulation

Author

G G, Corbucci, A, Menichetti, A, Cogliati, and C, Ruvolo

Subjects
Male, Extracorporeal Circulation, Ischemia, Myocardium, Reperfusion, Myocardial Ischemia, Humans, Myocardial Reperfusion, Middle Aged, Hypoxia, Muscle, Skeletal
Abstract

Extracorporeal circulation (ECC) during aortopulmonary bypass surgery allows the investigation of the metabolic and biochemical effects of hypoxia (skeletal muscle), ischaemia (cardiac muscle) and reperfusion (skeletal and cardiac muscle) in homogeneous groups of patients. In this study we examined the mitochondrial enzymic response to oxidative stress in 40 subjects, and analysis was carried out on heart and skeletal-muscle biopsies taken before, during and after aortic clamping and 115 min of ECC. The results obtained constitute a clinical and biochemical picture characterized by some peculiar adaptive changes of enzymic activities which thus antagonize the oxidative damage due to acute hypoxia, ischaemia and reperfusion. Consequently it seems that this cellular protective mechanism plays a crucial role in the reversibility of oxidative damage in hypoxic and ischaemic tissues.

Published
1995

36. Biochemical and biomolecular aspects of oxidative stress due to acute and severe hypoxia in human muscle tissue

Author

G G, Corbucci, R, Sessego, C, Velluti, and M, Salvi

Subjects
Electron Transport Complex IV, Succinate Dehydrogenase, Cytoplasm, Oxidative Stress, Muscles, Acute Disease, Humans, HSP70 Heat-Shock Proteins, Hypoxia, Adaptation, Physiological, Mitochondria, Muscle
Abstract

Mitochondrial oxidative stress was investigated in severe and acute hypoxia and in reperfusion applied to human muscle tissues. The biochemical and biomolecular relationship between the response of the respiratory-chain enzymic complexes and the metabolism of specific hypoxia stress proteins (HSP) suggest an adaptive mechanism which antagonizes the oxidative damage due to acute and severe tissue hypoxia.

Published
1995

37. Poster Session 1

Author

A. Deshmukh, S. S. Sharma, F. G. Gobal, S. S. Singla, P. H. Hebbar, H. P. Paydak, M. Igarashi, H. Tada, Y. Sekiguchi, H. Yamasaki, K. Kuroki, T. Machino, K. Yoshida, K. Aonuma, J. Shavadia, H. Otieno, G. Yonga, A. Jinah, J. F. Qvist, P. H. Soerensen, U. Dixen, M. A. Ramirez-Marrero, B. Perez-Villardon, D. Gaitan-Roman, M. Jimenez-Navarro, J. L. Delgado-Prieto, E. De Teresa-Galvan, M. De Mora-Martin, P. B. Hebbar, W. X. Wei, S. Bardari, M. Zecchin, R. Salame', L. Vitali Serdoz, A. Di Lenarda, N. Guerrini, G. Barbati, G. Sinagra, K. Hanazawa, K. Kaitani, Y. Nakagawa, I. Lenaerts, R. Driesen, N. Hermida, H. Heidbuchel, S. Janssens, J. L. Balligand, K. R. Sipido, R. Willems, R. Sehra, D. Krummen, C. Briggs, S. Narayan, Y. Tanaka, K. Hirao, T. Nakamura, O. Inaba, A. Yagishita, K. Higuchi, H. Hachiya, M. Isobe, E. Kallergis, E. M. Kanoupakis, H. E. Mavrakis, C. A. Goudis, N. E. Maliaraki, P. E. Vardas, K. Kiuchi, C. Piorkowski, S. Kircher, T. Gaspar, N. Watanabe, A. Bollmann, G. Hindricks, K. Wauters, A. Grosse, S. Raffa, M. Brunelli, J. C. Geller, A. P. Maggioni, L. Gonzini, G. Gussoni, G. Vescovo, M. Gulizia, S. Pirelli, G. Mathieu, G. Di Pasquale, R. Salame, S. Magnani, T. Sakamoto, K. Kumagai, E. Fuke, S. Nishiuchi, T. Hayashi, Y. Miki, S. Naito, S. Oshima, I. E. Hof, E. Vonken, B. K. Velthuis, M. Meine, R. N. W. Hauer, K. P. Loh, J. O. Na, C. U. Choi, E. J. Kim, S. W. Rha, C. G. Park, H. S. Seo, D. J. Oh, H. E. Lim, D. Wichterle, V. Bulkova, M. Fiala, J. Chovancik, J. Simek, P. Peichl, R. Cihak, J. Kautzner, A. Glick, S. Viskin, B. Belhassen, A. Navarrete, F. Conte, A. Ishti, D. Sai, M. Moran, Z. Chitovova, H. Ahmed, K. Mares, J. Skoda, L. Sediva, J. Petru, V. Y. Reddy, P. Neuzil, M. Schmidt, U. Dorwarth, A. Leber, M. Wankerl, J. Krieg, F. Straube, S. Reif, E. Hoffmann, E. Mikhaylov, V. Tikhonenko, D. Lebedev, S. Y. Shin, H. S. Yong, J. I. Choi, S. H. Kim, S. Matsuo, T. Yamane, M. Hioki, K. Ito, R. Narui, T. Date, K. Sugimoto, M. Yoshimura, S. Rolf, P. Sommer, R. Batalov, S. Popov, I. Antonchenko, T. Suslova, S. Fichtner, U. Czudnochowsky, H. L. Estner, S. Ammar, T. Reents, C. Jilek, G. Hessling, I. Deisenhofer, E. Pokushalov, A. Romanov, G. Corbucci, S. Artemenko, D. Losik, V. Shabanov, A. Turov, D. Elesin, M. Abramov, P. Sanders, P. Jais, K. Roberts-Thomson, K. Fukumoto, S. Takatsuki, T. Kimura, N. Nishiyama, Y. Aizawa, T. Sato, S. Miyoshi, K. Fukuda, Y. Roux, J. Tenkorang, P. Carroz, J. Schlaepfer, P. Pascale, A. Forclaz, M. Fromer, E. Pruvot, L. Sknouril, R. Nevralova, M. Dorda, J. Januska, R. Santi, C. Geller, K. Nakamura, K. Kasseno, K. Taniguchi, A. Wutzler, M. Huemer, A. Parwani, L. H. Boldt, D. Blaschke, R. Dietz, W. Haverkamp, B. Coutu, R. Malanuk, M. Ait Said, A. Vicentini, S. Schade, K. Ando, A. Rousseauplasse, T. Deering, B. C. Picarra, A. R. Santos, P. Dionisio, P. Semedo, R. Matos, M. Leitao, A. Jacinto, M. Trinca, C. Wan, J. Glad, S. Szymkiewicz, M. Habibovic, H. Versteeg, A. J. M. Pelle, D. A. M. J. Theuns, L. Jordaens, S. S. Pedersen, S. Pakarinen, L. Toivonen, J. Taggeselle, A. Frey, A. Birkenhagen, S. Kohler, S. K. G. Maier, N. Lobitz, S. Paule, J. Becher, G. Mustafa, A. Ibrahim, G. King, B. Foley, B. Wilkoff, R. Freedman, D. Hayes, S. Kalbfleisch, S. Kutalek, R. Schaerf, I. A. Fazal, M. Tynan, C. J. Plummer, J. M. Mccomb, A. Oto, K. Aytemir, H. Yorgun, U. Canpolat, E. B. Kaya, L. Tokgozoglu, G. Kabakci, H. Ozkutlu, S. Greenberg, F. Hamati, R. Styperek, J. Alonso, D. Peress, O. Bolanos, R. Augostini, M. Pelini, S. Zhang, S. Stoycos, S. Witsaman, K. Mowrey, J. Bremer, A. Oza, G. Ciconte, P. Mazzone, G. Paglino, A. Marzi, P. Vergara, N. Sora, S. Gulletta, P. Della Bella, M. Nagashima, M. Goya, Y. Soga, K. Hiroshima, K. Andou, K. Hayashi, Y. An, M. Nobuyoshi, A. Kutarski, B. Malecka, R. Pietura, P. Osmancik, D. Herman, P. Stros, V. Kocka, P. Tousek, H. Linkova, M. Bortnik, E. Occhetta, G. Dell'era, A. Degiovanni, L. Plebani, P. N. Marino, M. V. Gorev, D. G. Alimov, P. Raju, S. Kully, S. Ugni, S. Furniss, G. Lloyd, N. R. Patel, M. W. Richards, C. E. Warren, M. H. Anderson, M. Hero, J. L. Rey, S. Ouali, S. Azzez, S. Kacem, S. Hammas, H. Ben Salem, E. Neffeti, F. Remedi, E. Boughzela, M. B. Kronborg, P. T. Mortensen, S. H. Poulsen, J. C. Nielsen, E. N. Simantirakis, J. E. Kontaraki, E. G. Arkolaki, S. I. Chrysostomakis, E. G. Nyktari, A. P. Patrianakos, R. C. Funck, C. Harink, H. H. Mueller, S. Koelsch, B. Maisch, V. Bolzani, P. Costandi, R. E. Shehada, N. Butala, B. Coppola, M. Taborsky, P. Heinc, M. Fedorco, V. Doupal, A. Di Cori, G. Zucchelli, E. Soldati, L. Segreti, R. De Lucia, S. Viani, L. Paperini, M. G. Bongiorni, K. J. Gutleben, W. Kranig, C. Barr, M. M. Morgenstern, M. Simon, Y. H. Dalal, M. Landolina, A. Pierantozzi, T. Agricola, M. Lunati, E. Pisano', G. Lonardi, G. Bardelli, G. Zucchi, B. Thibault, M. Dubuc, E. Karst, K. Ryu, P. Paiement, M. D. Carlson, T. Farazi, H. Alhous, L. Mont, J. M. Porres, J. Alzueta, X. Beiras, I. Fernandez-Lozano, A. Macias, R. Ruiz, J. Brugada, S. M. Viani, M. Seifert, T. Schau, V. Moeller, J. Meyhoefer, C. Butter, V. Ganiere, V. Niculescu, G. Domenichini, C. Stettler, P. Defaye, H. Burri, M. Stockburger, E. De Teresa, G. Lamas, M. Desaga, C. Koenig, E. Cobo, X. Navarro, U. Wiegand, M. Blich, S. Carasso, M. Suleiman, I. Marai, L. Gepstein, M. Boulos, M. Sasov, B. Liska, P. Margitfalvi, T. Malacky, M. Svetlosak, E. Goncalvesova, R. Hatala, Y. Takaya, T. Noda, Y. Yamada, H. Okamura, K. Satomi, W. Shimizu, N. Aihara, S. Kamakura, A. Proclemer, S. Boveda, H. Oswald, P. Scipione, A. Da Costa, W. Brzozowski, A. Tomaszewski, A. Wysokinski, E. Arbelo, D. Tamborero, B. Vidal, J. M. Tolosana, M. Sitges, M. Matas, G. L. Botto, C. D. Dicandia, M. Mantica, C. La Rosa, A. D' Onofrio, G. Molon, G. Raciti, R. Verlato, P. W. X. Foley, S. Chalil, K. Ratib, R. E. A. Smith, F. Printzen, A. Auricchio, F. Leyva, R. Abu Sham'a, J. Buber, D. Luria, R. Kuperstein, M. Feinberg, H. Granit, M. Eldar, M. Glikson, K. Vondrak, E. Nof, I. Lipchenca, R.- G. Vatasescu, C. Iorgulescu, C. Caldararu, A. Vasile, S. Bogdan, D. Constantinescu, M. Dorobantu, H. Sakaguchi, A. Miyazaki, T. Yamamoto, K. Fujimoto, S. Ono, H. Ohuchi, M. Martinelli, S. Martins, R. Molina, S. Siqueira, S. A. D. Nishioka, G. L. Peixoto, R. Alkmim-Teixeira, R. Costa, M. M. Meine, A. E. Tuinenburg, P. A. Doevendans, J. Denollet, K. Goscinska-Bis, I. Zupan, H. Van Der, F. Anselme, H. Hartog, M. Block, A. Borri, L. Padeletti, M. Toniolo, G. Zanotto, A. Rossi, E. Raytcheva, L. Tomasi, C. Vassanelli, I. Fernandez Lozano, C. Mitroi, J. Toquero Ramos, V. Castro Urda, V. Monivas Palomero, A. Corona Figueroa, L. Ruiz Bautista, L. Alonso Pulpon, A. S. Jadidi, F. Sacher, A. S. Shah, D. Scherr, N. Derval, M. Hocini, M. Haissaguerre, S. Castrejon Castrejon, C. Largo-Aramburu, J. Sachar, E. Gang, A. Estrada, D. Doiny, E. De Miguel, J. L. Merino, N. Trevisi, A. Ricco, F. Petracca, F. Baratto, A. Bisceglie, G. Maccabelli, A. El-Damaty, J. Sapp, J. Warren, P. Macinnis, M. Horacek, B. Dinov, R. Schoenbauer, F. Braunschweig, A. Arya, D. Andreu, A. Berruezo, J. T. Ortiz, E. Silva, T. M. De Caralt, J. Fernandez-Armenta, A. Perez-Silva, M. Ortega, J. L. Lopez-Sendon, F. Regoli, F. Faletra, G. Nucifora, E. Pasotti, T. Moccetti, C. Klersy, M. Casella, A. Dello Russo, M. Moltrasio, M. Zucchetti, G. Fassini, L. Di Biase, A. Natale, C. Tondo, N. Matsuhashi, H. J. Weig, G. Kerst, S. Weretk, P. Seizer, M. P. Gawaz, J. Schreieck, G. Sarquella-Brugada, F. Prada, C. M. Salling, C. Kolb, M. Pytkowski, A. Maciag, M. Farkowski, A. Jankowska, I. Kowalik, A. Kraska, H. Szwed, P. Maury, A. Duparc, P. Mondoly, A. Rollin, R. Pap, M. Kohari, G. Bencsik, A. Makai, L. Saghy, T. Forster, E. Ebrille, M. Scaglione, C. Raimondo, D. Caponi, P. Di Donna, A. Blandino, S. D. L. Delcre, F. Gaita, I. Roca Luque, L. D. S. Dos, N. R. G. Rivas, A. P. D. Pijuan, J. Perez, J. Casaldaliga, D. G. D. Garcia-Dorado, A. M. M. Moya, H. Sato, T. Yagi, T. Yambe, F. Streitner, C. Dietrich, E. Mahl, N. Schoene, C. Veltmann, M. Borggrefe, J. Kuschyk, P. P. Sadarmin, K. C. K. Wong, K. Rajappan, Y. Bashir, T. R. Betts, C. Leclercq, R. Martins, J. C. Daubert, P. Mabo, M. Koide, G. Hamano, T. Taniguchi, M. Yamato, N. Sasaki, K. Hirooka, Y. Ikeda, Y. Yasumura, W. Dichtl, T. Wolber, U. Paoli, S. Bruellmann, T. Berger, M. Stuehlinger, F. Duru, F. Hintringer, E. Kanoupakis, H. Mavrakis, E. Koutalas, I. Saloustros, C. Goudis, G. Chlouverakis, P. Vardas, J. M. Herre, M. Saeed, L. Saberi, S. Neuman, K. Yamaji, M. Iwabuchi, A. Baranchuk, F. Femenia, R. Miranda Hermosilla, J. C. Lopez Diez, J. L. Serra, M. Valentino, E. Retyk, N. Galizio, W. Kwasniewski, A. Filipecki, W. Orszulak, D. Urbanczyk-Swic, M. Trusz - Gluza, O. Piot, B. Degand, A. Donofrio, P. Scanu, A. Quesada, A. Kloppe, D. Mijic, H. Bogossian, M. Zarse, B. Lemke, J. Tyler, G. Comfort, T. F. Deering, A. E. Epstein, S. M. G. Greenberg, D. S. Goldman, J. Rhude, J. P. Majewski, J. Lelakowski, I. Tomala, C. M. Santos, R. S. Miranda, P. J. Sousa, D. M. Cavaco, P. P. Adragao, R. E. Knops, A. A. Wilde, M. Belhameche, J. S. Hermida, E. Dovellini, G. Frohlig, P. Siot, G. Z. Duray, C. W. Israel, J. Brachmann, K. H. Seidl, M. Foresti, F. Birkenhauer, S. H. Hohnloser, C. Ferreira, P. Mateus, H. Ribeiro, S. Carvalho, A. Ferreira, J. Moreira, W. Kadro, H. Rahim, M. Turkmani, M. Abu Lebdeh, A. Altabban, N. Cerrato, S. Rivera, F. Scazzuso, G. Albina, A. Klein, R. Laino, V. Sammartino, A. Giniger, T. Kvantaliani, M. Akhvlediani, M. Namdar, J. Steffel, S. Jetzer, F. Bayrak, G. B. Chierchia, R. Jenni, P. Brugada, Z. Bakos, M. M. Medvedev M, J. C. Jonas Carlsson, F. H. Fredrik Holmqvist, P. P. Pyotr Platonov, T. Nurbaev, M. Pirnazarov, A. Nikishin, P. Aagaard, A. Sahlen, L. Bergfeldt, E. Simeonidou, S. Kastellanos, C. Varounis, C. Michalakeas, C. Koniari, A. Nikolopoulou, M. Anastasiou-Nana, Y. Furukawa, T. Yamada, T. Morita, K. Tanaka, Y. Iwasaki, M. Kawasaki, Y. Kuramoto, M. Fukunami, C. Blanche, N. Tran, F. Rigamonti, M. Zimmermann, E. Okisheva, D. Tsaregorodtsev, V. Sulimov, D. Novikova, T. Popkova, E. Udachkina, Y. Korsakova, A. Volkov, A. Novikov, E. Alexandrova, E. Nasonov, P. Arsenos, K. Gatzoulis, G. Manis, P. Dilaveris, T. Gialernios, E. Kartsagoulis, S. Asimakopoulos, C. Stefanadis, M. Marocolo, O. Barbosa Neto, A. C. Carvalho, S. R. Marques Neto, G. R. Mota, P. R. B. Barbosa, A. Fernandez-Fernandez, S. Manzano Fernandez, F. J. Pastor-Perez, O. Barquero-Perez, R. Goya-Esteban, M. Salar, J. L. Rojo-Alvarez, A. Garcia-Alberola, M. Takigawa, M. Kawamura, T. Aiba, T. Sakaguchi, H. Itoh, M. Horie, T. Igarashi, J. Negishi, N. Toyota, O. Yamada, M. Papavasileiou, F. Cabrera Bueno, M. J. Molina Mora, J. Alzueta Rodriguez, A. Barrera Cordero, E. De Teresa Galvan, A. S. Revishvili, T. Dzhordzhikiya, O. Sopov, G. Simonyan, O. Lyadzhina, E. Fetisova, V. Kalinin, J. C. Balt, R. C. Steggerda, L. V. A. Boersma, M. C. E. F. Wijffels, E. F. D. Wever, J. M. Ten Berg, R. P. Ricci, L. Morichelli, A. D'onofrio, D. Vaccari, L. Calo', G. Buja, N. Rovai, A. Gargaro, J. Sperzel, G. Speca, L. Santini, J. Haarbo, K. Dubin, M. Carlson, A. Garcia Quintana, H. Mendoza-Lemes, L. Garcia Perez, S. Led Ramos, E. Caballero Dorta, M. Matinez De Espronceda, V. Piro Mastracchio, L. Serrano Arriezu, L. Sciarra, M. Marziali, E. Marras, M. Rebecchi, G. Allocca, E. Lioy, P. Delise, V. E. Santobuono, M. Iacoviello, F. Nacci, G. Luzzi, A. Puzzovivo, M. Memeo, F. Quadrini, S. Favale, M. E. Trucco, M. Arce, J. Palazzolo, W. Uribe, R. Maggi, T. Furukawa, F. Croci, A. Solano, M. Brignole, A. Lebreiro, A. Sousa, A. S. Correia, P. Lourenco, S. Oliveira, M. Paiva, J. Freitas, M. J. Maciel, N. Linker, G. Rieger, C. Garutti, N. Edvardsson, R. Salguero Bodes, M. De Riva Silva, A. Fontenla Cerezuela, M. Lopez Gil, E. Mejia Martinez, A. Jurado Roman, S. Garcia Alvarez, F. Arribas Ynsaurriaga, N. R. Petix, A. Del Rosso, V. Guarnaccia, A. Zipoli, F. Rabajoli, G. Foglia Manzillo, C. Tolardo, C. Checchinato, S. Chiaravallotti, M. Santarone, M. T. Spinnler, C. Podoleanu, A. Frigy, D. Dobreanu, C. Ginghina, and E. Carasca

Subjects
Lv function, medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business, Predictive value, Value (mathematics), Surgery
Abstract

was higher in the NRG (p 0.70 was the more accurate RT-MCE value to predict LV regional recovery with positive predictive value of 70% and negative predictive value of 56% (p

Published
2011
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38. Poster Session 2

Author

T. Andersson, A. Magnusson, I.- L. Bryngelsson, O. Frobert, K. M. Henriksson, N. Edvardsson, D. Poci, M. Polovina, T. Potpara, M. Licina, N. Mujovic, A. Kocijancic, D. Simic, M. C. Ostojic, R. A. Providencia, A. Botelho, J. Trigo, J. Nascimento, N. Quintal, P. Mota, A. M. Leitao-Marques, R. F. Bosch, W. Kirch, L. Rosin, S. N. Willich, D. Pittrow, H. Bonnemeier, M. C. Valenza, L. Martin, T. Munoz Casaubon, G. Valenza, M. Botella, M. Serrano, B. Valenza, I. Cabrera, K. Anderson, B. S. Benzaquen, N. Koziolova, J. Nikonova, Y. Shilova, D. Scherr, S. Narayan, M. Wright, D. Krummen, A. Jadidi, P. Jais, M. Haissaguerre, M. Hocini, R. Hunter, Y. Liu, Y. Lu, W. Wang, R. J. Schilling, S. Bernstein, B. Wong, R. Rooke, C. Vasquez, R. Shah, S. Rosenberg, L. Chinitz, G. Morley, M. Bashir Choudhary, F. Holmqvist, J. Carlson, H.- J. Nilsson, P. G. Platonov, A. S. Jadidi, H. Cochet, S. Miyazaki, A. J. Shah, N. Marrouche, N. Calvo, M. Nadal, D. Andreu, D. Tamborero, F. E. Diaz, A. Berruezo, J. Brugada, L. Mont, S. Fichtner, G. Hessling, H. L. Estner, C. Jilek, T. Reents, S. Ammar, J. Wu, I. Deisenhofer, H. Nakanishi, K. Kashiwase, A. Hirata, M. Wada, Y. Ueda, J. Skoda, P. Neuzil, J. Popelova, J. Petru, L. Sediva, V. Y. Reddy, L. Uldry, A. Forclaz, N. Virag, J.- M. Vesin, L. Kappenberger, R. Sehra, C. Briggs, W.- J. Rappel, M. Janotka, M. Chovanec, K. Yamashiro, K. Takami, Y. Sakamoto, K. Satoh, T. Suzuki, H. Nakagawa, A. Romanov, E. Pokushalov, S. Artemenko, V. Shabanov, I. Stenin, D. Elesin, A. Turov, A. Yakubov, M. Hioki, S. Matsuo, K. Ito, R. Narui, S. Yamashita, K. Sugimoto, M. Yoshimura, T. Yamane, L. Di Biase, J. D. Gallinghouse, K. Rajappan, J. Kautzner, A. Dello Russo, C. Tondo, F. Lorgat, A. Natale, O. Balta, K. Buenz, M. Paessler, H. Anders, M. Horlitz, T. Deneke, L. Lickfett, I. Liberman, M. Linhart, R. Andrie, E. Mittmann-Braun, F. Stockigt, G. Nickenig, J. Schrickel, R. Tilz, A. Rillig, B. Feige, A. Metzner, A. Fuernkranz, A. Burchard, E. Wissner, F. Ouyang, T. R. Betts, M. A. Jones, K. C. K. Wong, N. Qureshi, Y. Bashir, G. Corbucci, D. Losik, V. Selina, M. A. Crandall, C. Daniels, E. Daoud, S. Kalbfleisch, H. Yamaji, T. Murakami, H. Kawamura, M. Murakami, K. Hina, S. Kusachi, G. Dakos, V. Vassilikos, S. Paraskevaidis, A. Mantziari, S. Theophylogiannakos, I. Chouvarda, I. Chatzizisis, I. Styliadis, T. Kimura, K. Fukumoto, N. Nishiyama, Y. Aizawa, Y. Fukuda, T. Sato, S. Miyoshi, S. Takatsuki, A. J. Navarrete Casas, I. Ali, F. C. Conte, M. Moran, B. G. Graham, O. Kalejs, R. Lacis, P. Stradins, A. Koris, I. Putnins, M. Vikmane, A. Lejnieks, A. Erglis, A. Estrada, A. Perez Silva, S. Castrejon, D. Doiny, J. L. Merino, A. Baranchuk, I. Greiss, C. S. Simpson, H. Abdollah, D. P. Redfearn, M. Buys-Topart, R. Nitzsche, B. Thibault, S. Kathan, C. Kolb, S. Reif, S. Schade, J. Taggeselle, A. Frey, A. Birkenhagen, S. Kohler, M. Schmidt, O. Cano Perez, F. Buendia, B. Igual, J. M. Osca, J. M. Sanchez, M. J. Sancho-Tello, J. M. Olague, A. Salvador, J. M. Tolosana, J. Fernandez-Armenta, M. Matas, M. C. Barbarin, M. Habibovic, K. C. Van Den Broek, D. A. M. J. Theuns, L. Jordaens, M. Alings, P. H. Van Der Voort, S. S. Pedersen, G. Pupita, S. Molini, M. Brambatti, A. Capucci, S. Molodykh, E. M. Idov, O. V. Belyaev, L. Segreti, E. Soldati, G. Zucchelli, A. Di Cori, S. Viani, L. Paperini, R. De Lucia, M. G. Bongiorni, L. Binner, M. Taborsky, D. Bello, H. Heuer, B. Ramza, I. Jenniskens, W. B. Johnson, M. S. Silvetti, L. Rava', M. S. Russo, C. Di Mambro, A. Ammirati, G. Gimigliano, M. Prosperi, F. Drago, A. R. Santos, B. Picarra, P. Semedo, P. Dionisio, R. Matos, M. Leitao, A. Jacinto, M. Trinca, P. Mazzone, G. Ciconte, A. Marzi, G. Paglino, P. Vergara, N. Sora, S. Gulletta, P. Della Bella, P. Koppitz, A. Fach, S. Hobbiesiefken, E. Fiehn, R. Hambrecht, J. Sperzel, M. Jung, J. Schmitt, D. Pajitnev, H. Burger, G. Goebel, W. Ehrlich, T. Walther, T. Ziegelhoeffer, V. Vancura, D. Wichterle, V. Melenovsky, M. Glikson, G. Goldenberg, A. Segev, D. Dvir, J. Kuzniec, A. Finkelstein, I. Hay, V. Guetta, W. K. Choo, S. Gupta, R. Kirkfeldt, J. Johansen, E. Nohr, M. Moller, P. Arnsbo, J. Nielsen, M. Banha, P. Stojanov, S. Raspopovic, D. Vasic, D. Savic, G. Nikcevic, V. Jovanovic, P. Defaye, B. Mondesert, A. Mbaye, R. Cassagneau, V. Gagniere, J. Jacon, V. Sanfins, H. R. Reis, J. N. Nobre, V. M. Martins, L. D. Duarte, C. M. Morais, J. C. Conceicao, M. Hero, J. L. Rey, A. Ducharme, C. Simpson, C. Stuglin, L. Blier, M. Senaratne, Y. Khaykin, A. Pinter, A. Mlynarska, R. Mlynarski, M. Sosnowski, J. Wilczek, C. Iorgulescu, S. Bogdan, D. Constantinescu, C. Caldararu, M. Dorobantu, A. Radu, R.- G. Vatasescu, S. Yusu, T. Ikeda, H. Mera, Y. Miwa, A. Abe, M. Miyakoshi, T. Tsukada, H. Yoshino, V. Nayar, P. Cantelon, A. Rawling, M. R. D. Belham, P. J. Pugh, J. Osca Asensi, O. Cano, D. Tejada, B. Munoz, M. Rodriguez, J. Olague, L. Wecke, A. Van Hunnik, T. Thompson, L. Di Carlo, M. Zdeblick, A. Auricchio, F. Prinzen, A. Doltra Magarolas, B. Bijnens, E. Silva, D. Penela, M. Sitges, P. Ofman, L. Navaravong, J. Leng, A. Peralta, P. Hoffmeister, R. Levine, J. Cook, M. Stoenescu, M. E. Tettamanti, A. Revilla Orodea, J. Lopez Diaz, L. De La Fuente Galan, R. Arnold, E. Garcia Moran, J. A. San Roman Calvar, I. Gomez Salvador, K. Nakamura, M. Takami, T. Keida, A. Mesato, S. Higa, M. Shimabukuro, H. Masuzaki, R. Proietti, A. Sagone, G. Domenichini, H. Burri, C. Valzania, M. Biffi, H. Sunthorn, G. Gavaruzzi, H. Foulkes, G. Boriani, S. Koh, W. Hou, J. Snell, J. Poore, N. Dalal, G. Bornzin, A. Kloppe, D. Mijic, H. Bogossian, I. Ninios, M. Zarse, B. Lemke, L. Guedon-Moreau, C. Kouakam, D. Klug, C. Marquie, F. Ziglio, S. Kacet, H. Mohamed Fereig Hamed, A. M. A. L. Hamdy, A. H. M. E. D. Abd El Aziz, M. R. V. A. T. Nabih, R. E. H. A. B. Hamdy, A. Yaminisaharif, G. H. Davoudi, A. Kasemisaeid, S. Sadeghian, A. Vasheghani Farahani, P. Yazdanifard, A. Shafiee, C. Alonso, C. Grimard, G. Jauvert, A. Lazarus, L. L. Mont, J. Ortiz-Perez, T. Caralt, J. Escudero, F. Perez, K. M. Griffith, R. Ferreyra, P. Urena, M. Demas, C. Muratore, H. Mazzetti, J. Guardado, M. Fernandes, V. H. Pereira, F. Canario-Almeida, F. Ferreira, B. Rodrigues, J. Almeida, A. Sokal, E. Jedrzejczyk, R. Lenarczyk, S. Pluta, O. Kowalski, P. Pruszkowska, A. Swiatkowski, Z. Kalarus, M. Heinke, B. Ismer, H. Kuehnert, T. Heinke, R. Surber, N. Osypka, D. Prochnau, H. R. Figulla, S. Iacopino, M. Landolina, A. Proclemer, L. Padeletti, V. Calvi, A. Pierantozzi, P. Di Stefano, A. Bauer, F. Bode, F. Le Gal, J. C. Deharo, M. Delay, J. Clementy, M. Kawamura, Y. Munetsugu, K. Tanno, Y. Kobayashi, D. Cannom, J. Hosoda, T. Ishikawa, K. Andoh, M. Nobuyoshi, S. Fujii, S. Shizuta, T. Isshiki, M. A. Castel, F. Perez-Villa, B. Vidal, P. Pruszkowska-Skrzep, M. Szulik, T. Kukulski, L. Gianfranchi, K. Bettiol, F. Pacchioni, P. Alboni, R. Abu Sham'a, J. Buber, E. Nof, R. Kuperstein, M. Feinberg, D. Luria, M. Eldar, K. Parks, J. R. Stone, J. P. Singh, E. Hatzinikolaou-Kotsakou, M. Kotsakou, T. H. Beleveslis, G. Moschos, E. Reppas, P. Latsios, K. Tsakiridis, A. Kazemisaeid, G. Davoodi, A. Yamini Sharif, M. Sheikhvatan, M. Toniolo, G. Zanotto, A. Rossi, L. Tomasi, C. Vassanelli, H. Versteeg, P. M. C. Mommersteeg, G. Vergara, J. Blauer, R. Ranjan, S. Vijayakumar, E. Kholmovski, N. Volland, R. Macleod, L. E. Aguinaga Arrascue, A. Bravo, P. Garcia Freire, P. Gallardo, E. Hasbani, J. Dantur, R. Quintana, P. P. Adragao, D. Cavaco, L. Parreira, K. Reis Santos, P. Carmo, R. Miranda, S. Marcelino, D. Cabrita, P. Sommer, T. Gaspar, S. Rolf, A. Arya, C. Piorkowski, G. Hindricks, E. Valles Gras, V. Bazan, L. Portillo, F. Suarez, J. Bruguera, J. Marti, Y. Huo, S. Richter, R. Schoenbauer, N. Rivas, J. Casaldaliga, I. Roca, L. Dos, J. Perez-Rodon, A. Pijuan, D. Garcia-Dorado, A. Moya, H. B. Carter, A. Garg, J. Hegrenes, H. J. Sih, L. R. Teplitsky, K. Kuroki, H. Tada, Y. Seo, T. Ishizu, M. Igawa, Y. Sekiguchi, K. Kuga, K. Aonuma, C. Rodriguez A, J. Mejias, P. Hidalgo, J. A. Hidalgo L, M. Orczykowski, P. Derejko, F. Walczak, E. Szufladowicz, P. Urbanek, R. Bodalski, K. Bieganowska, L. Szumowski, P. Peichl, R. Cihak, I. Skalsky, P. Kubus, P. Vit, L. Zaoral, R. A. Gebauer, M. Fiala, J. Janousek, K. Hiroshima, M. Goya, M. Ohe, K. Hayashi, Y. Makihara, M. Nagashima, Y. An, M. Schloesser, T. Lawrenz, D. Meyer Zu Vilsendorf, C. Strunk-Mueller, C. Stellbrink, J. Papagiannis, D. Avramidis, C. Kokkinakis, G. Kirvassilis, G. Eidelman, A. Arenal, T. Datino, F. Atienza, E. Gonzalez Torrecilla, A. Miracle, J. Hernandez, F. Fernandez Aviles, E. Ene, P. Insulander, H. Bastani, F. Braunschweig, N. Drca, G. Kenneback, J. Schwieler, J. Tapanainen, M. Jensen-Urstad, B. Andrea, E. M. A. Andrea, W. M. Maciel, L. S. Siqueira, R. C. Cosenza, F. M. Mittidieri, S. F. Farah, J. A. Atie, E. Kanoupakis, E. Kallergis, H. Mavrakis, C. Goudis, I. Saloustros, N. Malliaraki, G. Chlouverakis, P. Vardas, J. L. Bonnes, J. Jaspers Focks, S. W. Westra, M. A. Brouwer, J. L. R. M. Smeets, G. Inama, C. Pedrinazzi, F. Oliva, M. Senni, M. Zoni Berisso, S. Mostov, M. Haim, R. Nevzorov, D. Hasadi, B. Starsberg, A. Porter, J. Kuschyk, A. Schoene, F. Streitner, C. G. Veltmann, R. Schimpf, M. Borggrefe, U. Luesebrink, A. Gardiwal, H. Oswald, T. Koenig, D. Duncker, G. Klein, R. Bastiaenen, V. Batchvarov, O. Atty, J. H. Cheng, E. R. Behr, M. M. Gallagher, A. H. Starrenburg, K. Kraaier, M. F. Scholten, J. Van Der Palen, S. Adhya, L. A. Smith, T. Zhao, C. Bannister, R. H. Kamdar, M. Martinelli, S. Siqueira, R. Greco, S. A. D. Nishioka, A. A. A. Pedrosa, R. Alkmim-Teixeira, G. L. Peixoto, R. Costa, J. C. Nielsen, P. T. Mortensen, J. B. Johansen, W. Kwasniewski, A. Filipecki, D. Urbanczyk-Swic, W. Orszulak, M. Trusz - Gluza, J. Jimenez-Candil, J. Morinigo, C. Ledesma, C. Martin-Luengo, T. Vogtmann, M. Gomer, S. Stiller, V. Kuehlkamp, G. Zach, S. Loescher, S. Kespohl, G. Baumann, J. D. Snell, N. Korsun, J. R. Snell, B. Morley, R. Bharmi, Y. Nabutovsky, M. Mollerus, L. Naslund, A. Meyer, M. Lipinski, B. Libey, K. Dornfeld, A. Martin, M. Gallego, M. K. De Bie, J. B. Van Rees, C. J. Borleffs, J. Thijssen, J. W. Jukema, M. J. Schalij, L. Van Erven, E. T. Van Der Velde, T. A. Witteman, H. Foeken, T. Szili-Torok, F. Akca, K. Caliskan, F. Ten Cate, M. Michels, D. C. Cozma, L. Petrescu, C. Mornos, S. I. Dragulescu, J. A. Groeneweg, B. K. Velthuis, M. G. P. J. Cox, P. Loh, D. Dooijes, M. J. Cramer, J. M. T. De Bakker, R. N. W. Hauer, S. D. Park, S. H. Shin, S. I. Woo, J. Kwan, K. S. Park, D. H. Kim, A. Iorio, L. Vitali Serdoz, F. Brun, E. Daleffe, M. Zecchin, M. Dal Ferro, S. Santangelo, G. F. Sinagra, S. Ouali, R. Hammemi, S. Hammas, S. Kacem, R. Gribaa, E. Neffeti, F. Remedi, E. Boughzela, P. Korantzopoulos, K. Letsas, Z. Christogiannis, K. Kalantzi, A. Ntorkos, J. Goudevenos, P. W. X. Foley, L. Yung, E. Barnes, M. Kikuchi, H. Ito, F. Miyoshi, R. Pecini, J. M. Marott, G. B. Jensen, J. Theilade, T. Mine, T. Kodani, T. Masuyama, I. M. Mozos, C. Serban, C. Costea, L. Susan, P. Barthel, A. Mueller, M. Malik, G. Schmidt, O. Karakurt, H. Kilic, D. R. Munevver Sari, D. Mroczek-Czernecka, A. Z. Pietrucha, A. Borowiec, M. Wnuk, I. Bzukala, O. Kruszelnicka, E. Konduracka, J. Nessler, Y. Kikuchi, A. Meireles, C. Gomes, D. Anjo, C. Roque, A. Pinheiro Vieira, V. Lagarto, A. Hipolito Reis, S. Torres, L. Miller, G. Vedrenne, E. Bruguiere, A. Redheuil, T. Lavergne, J. Y. Le Heuzey, E. Mousseaux, A. Hersi, K. Alhabib, H. Alfaleh, K. Sulaiman, W. Almahmeed, J. Alsuwidi, H. Amin, A. Almotarreb, H. W. K. Pang, K. Michael, E. J. Pereira, P. W. Munt, M. F. Fitzpatrick, A. S. Revishvili, G. Simonyan, T. Dzhordzhikiya, O. Sopov, V. Kalinin, E. T. Locati, A. M. Vecchi, G. Cattafi, A. Sachero, M. Lunati, S. Sayah, A. Alizadeh, N. Nazari, M. Hekmat, M. Moradi, M. Zeighami, H. Ghanji, K. Suzuki, M. Takagi, K. Maeda, H. Tatsumi, P. Vieira, H. Reis, A. Toth, H. Vago, P. Takacs, E. Edes, A. Marki, G. Y. Balazs, K. Huttl, B. Merkely, F. Lainis, M. M. Buckley, E. J. Johns, C. M. Seifer, L. Daba, K. Liebrecht, W. Piwowarska, J. Toquero Ramos, E. Perez Pereira, C. Mitroi, V. Castro Urda, J. M. Fernandez Villanueva, A. Corona Figueroa, L. Hernandez Reina, I. Fernandez Lozano, A. Bartoletti, P. Bocconcelli, S. Giuli, R. Massa, C. Svetlich, G. Tarsi, F. Tronconi, E. Vitale, P. Stryjewski, M. Wegrzynowska, A. Lousinha, J. Labandeiro, E. Antunes, S. Silva, S. Alves, A. Timoteo, M. Oliveira, R. Cruz Ferreira, and J. Jedrzejczyk-Spaho

Subjects
medicine.medical_specialty, Voltage-dependent calcium channel, business.industry, medicine.drug_class, Umbilical artery, 030204 cardiovascular system & hematology, Cyclase, 3. Good health, Low testosterone levels, 03 medical and health sciences, 0302 clinical medicine, Bkca channel, Endocrinology, Physiology (medical), Internal medicine, medicine.artery, Natriuretic peptide, Medicine, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Ionic Channels
Abstract

Inthelastdecadesseveralinvestigatorshavesuggestedtheassociationofandrogenswithhypertension. Recently, some studies have shown that the incidence of cardiovascular diseases is increased in men with low testosterone levels, suggesting a protective role of androgens. Hypertension is one of the mostcommonproblemsinpregnancythatcomplicates5-10 %ofpregnancies.Anincreaseofmorbidity wasobservedinbabiesfrompregnantwomenwithhypertension.However,thepathogenesisremains unclearandthislimitstheabilitytopreventandtreatthispathology.Thebeneficialeffectsofandrogens for vascular system are associated with their ability to cause vasorelaxation. Inhuman vessels, this non genomiceffectofandrogensappeartobeduetoactivationoflargeconductancecalcium-activatedpotassiumchannels(BKCa)andvoltagegatedpotassiumchannels(KV)whichisinducedbycGMPincrease andaconsequentactivationofcGMP-dependentproteinkinase(PKG).Ontheotherhand,thegenomic effects of androgens concerning ionic channels are almost unknown. Our previous studies suggested that androgens increase the expression of BKCa channels and decrease expression of L-type calcium channels (LTCC). The aim of this work was to analyze the genomic effects of androgens on theexpressionofotherproteinsinvolvedintheregulationofvascularcontractility,suchassolubleguanylate cyclase (sGC), the natriuretic peptide receptor-A (NPRA) and PKG. This study also aimed to compare the expression levels of these proteins in human umbilical artery (HUA) from normotensive andhypertensivepregnantwomen.ToachievethesegoalsrealtimePCRwasperformedusingsmooth

Published
2011
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39. Poster Session 3

Author

G. M. T. Fabbri, S. Baldasseroni, D. Panuccio, M. Zoni Berisso, M. Scherillo, D. Lucci, G. Di Pasquale, G. Mathieu, I. Burazor, M. Burazor, Z. Perisic, V. Atanaskovic, V. Erakovic, A. Stojkovic, T. Vogtmann, C. Schoebel, S. Sogorski, M. Sebert, J. Schaarschmidt, I. Fietze, G. Baumann, T. Penzel, C. Mornos, A. Ionac, D. Cozma, D. Dragulescu, A. Mornos, L. Petrescu, L. Pescariu, B. Brembilla-Perrot, H. Khachab, F. Lamberti, C. Bellini, R. Remoli, T. Cogliandro, R. Nardo, F. Bellusci, V. Mazzuca, A. Gaspardone, L. E. Aguinaga Arrascue, A. Bravo, P. Garcia Freire, P. Gallardo, E. Hasbani, R. Quintana, J. Dantur, K. Inoue, A. Ueoka, Y. Tsubakimoto, T. Sakatani, A. Matsuo, H. Fujita, M. Kitamura, M. Wegrzynowska, E. Konduracka, A. Z. Pietrucha, D. Mroczek-Czernecka, A. Paradowski, I. Bzukala, J. Nessler, O. Igawa, M. Adachi, H. Atarashi, Y. Kusama, E. Kodani, R. Okazaki, A. Nakagomi, Y. Endoh, J. L. Baez-Escudero, A. S. Dave, C. M. Sasaridis, M. Valderrabano, R. Tilz, R. Bai, L. Di Biase, G. J. Gallinghouse, D. Gibson, A. Pisapia, O. Wazni, A. Natale, A. Arujuna, R. Karim, A. Rinaldi, M. Cooklin, K. Rhode, R. Razavi, M. O'neill, J. Gill, S. Kusa, Y. Komatsu, K. Kakita, K. Takayama, H. Taniguchi, K. Otomo, Y. Iesaka, S. Ammar, T. Reents, S. Fichtner, J. Wu, P. Zhu, C. Kolb, G. Hessling, I. Deisenhofer, G. Gilbert, P. Mohanty, J. Cunningham, T. Metz, R. Horton, S. Tao, Y. Yamauchi, H. Okada, S. Maeda, T. Obayashi, M. Isobe, J. Chan, S. Johar, T. Wong, V. Markides, W. Hussain, M. Konstantinidou, E. Wissner, A. Fuernkranz, Y. Yoshiga, A. Metzner, K.- H. Kuck, F. Ouyang, K. Kettering, F. Gramley, H. Mollnau, C. Weiss, S. Bardeleben, L. Biasco, M. Scaglione, D. Caponi, P. Di Donna, D. Sergi, N. Cerrato, A. Blandino, F. Gaita, M. Fiala, D. Wichterle, L. Sknouril, V. Bulkova, J. Chovancik, R. Nevralova, J. Pindor, J. Januska, J. I. Choi, J. E. Ban, N. Yasutsugu, J. S. Park, J. S. Jung, H. E. Lim, S. W. Park, Y. H. Kim, M. Kuhne, T. Reichlin, P. Ammann, B. Schaer, S. Osswald, C. Sticherling, M. Ohe, M. Goya, K. Hiroshima, K. Hayashi, Y. Makihara, M. Nagashima, M. Fukunaga, Y. An, U. Dorwarth, M. Schmidt, M. Wankerl, J. Krieg, F. Straube, E. Hoffmann, S. Kathan, P. Defaye, A. Mbaye, R. Cassagneau, V. Gagniere, P. Jacon, E. Pokushalov, A. Romanov, S. Artemenko, V. Shabanov, D. Elesin, I. Stenin, A. Turov, D. Losik, K. Kondo, J. Miake, A. Yano, K. Ogura, M. Kato, C. Shigemasa, Y. Sekiguchi, H. Tada, K. Yoshida, Y. Naruse, H. Yamasaki, M. Igarashi, T. Machino, K. Aonuma, S. Chen, S. Liu, G. Chen, W. Meng, F. Zhang, Y. Yan, L. Sciarra, S. Dottori, C. Lanzillo, E. De Ruvo, L. De Luca, M. Minati, E. Lioy, L. Calo', J. Lin, Z. Nie, M. Zhu, X. Wang, J. Zhao, W. Hu, H. Tao, J. Ge, B. Johansson, B. Houltz, N. Edvardsson, H. Schersten, T. Karlsson, B. Wandt, E. Berglin, R. H. Hoyt, B. P. Jenson, S. A. I. P. Trines, J. Braun, A. Tjon Joek Tjien, K. Zeppenfeld, G. Tavilla, R. J. M. Klautz, M. J. Schalij, R. Krausova, R. Cihak, P. Peichl, J. Kautzner, J. Pirk, I. Skalsky, J. Maly, K. Imai, T. Sueda, K. Orihashi, B. C. Picarra, A. R. Santos, P. Dionisio, P. Semedo, R. Matos, M. Leitao, M. Banha, M. Trinca, D. H. J. Elder, J. George, R. Jain, C. C. Lang, A. M. Choy, M. Konert, S. Loescher, A. Hartmann, E. Aversa, R. Chirife, E. Sztyglic, H. Mazzetti, O. Mascheroni, M. C. Tentori, R. M. Pop, A. D. Margulescu, R. Dulgheru, O. Enescu, C. Siliste, D. Vinereanu, A. Menezes Junior, A. R. Castro Carneiro, B. L. De Oliveira, A. N. Shah, B. Kantharia, R. De Lucia, E. Soldati, L. Segreti, A. Di Cori, G. Zucchelli, S. Viani, L. Paperini, M. G. Bongiorni, A. Kutarski, M. Czajkowski, R. Pietura, B. Malecka, J. Heintze, L. Eckardt, A. Bauer, M. Meine, L. Van Erven, P. E. Bloch Thomsen, M. P. Lopez Chicharro, O. Merhi, Y. Soga, K. Andou, M. Nobuyoshi, A. Gonzalez-Mansilla, R. Martin-Asenjo, L. Unzue, J. Torres, E. Garralda, R. R. Coma, J. E. Rodriguez Garcia, T. Yaegashi, H. Furusho, T. Kato, A. Chikata, S. Takashima, S. Usui, M. Takamura, S. Kaneko, M. Chudzik, P. Mitkowski, A. Przybylski, J. Lewek, T. Smukowski, A. Maciag, S. Castrejon Castrejon, A. Perez-Silva, A. Estrada, D. Doiny, M. Ortega, J. L. Lopez-Sendon, J. L. Merino, C. O'mahony, C. Coats, M. Cardona, A. Garcia, M. Calcagnino, R. Lachmann, D. Hughes, P. M. Elliott, S. Conti, G. P. Pruiti, E. Puzzangara, S. A. Romano, A. Di Grazia, G. P. Ussia, C. Tamburino, V. Calvi, A. Radinovic, S. Sala, A. Latib, M. Mussardo, S. Sora, G. Paglino, M. Gullace, A. Colombo, M.- A. G. Ohlow, B. Lauer, A. Wagner, M. Schreiber, B. Buchter, A. Farah, J. T. Fuhrmann, J. C. Geller, R. M. Nascimento Cardoso, L. A. Batista Sa, L. F. C. Campos Filho, S. V. Rodrigues, M. V. F. Dutra, T. R. S. A. Borges, D. R. Portilho, T. Deering, A. Bernardes, A. Veiga, O. Gartenlaub, A. Goncalves, A. Jimenez, A. Rousseauplasse, J. C. Deharo, H. Striekwold, G. Gosselin, H. Sitbon, V. Martins, G. Molon, F. Ayala-Paredes, M. J. Sancho-Tello, I. A. Fazal, S. Brady, J. Cronin, S. Mcnally, M. Tynan, C. J. Plummer, J. M. Mccomb, J. E. Val-Mejias, R. M. Oliveira, R. Costa, M. Martinelli Filho, K. R. Silva, L. M. Menezes, W. T. Tamaki, W. Mathias, N. A. G. Stolf, T. Misawa, I. Ohta, T. Shishido, T. Miyasita, T. Miyamoto, J. Nitobe, T. Watanabe, I. Kubota, B. Thibault, A. Ducharme, C. Simpson, C. Stuglin, C. E. Gagne, R. Williams, S. Mcnicoll, M. S. Silvetti, F. Drago, D. Penela, B. Bijnens, A. Doltra, E. Silva, A. Berruezo, L. Mont, M. Sitges, R. Mcintosh, O. Baumann, P. Raju, S. Gurunathan, S. Furniss, N. Patel, N. Sulke, G. Lloyd, M. Mor, S. Dror, Y. Tsadok, N. Bachner-Hinenzon, A. Katz, N. Liel-Cohen, Y. Etzion, R. Mlynarski, A. Mlynarska, J. Wilczek, M. Sosnowski, A. M. Sinha, D. Sinha, G. Noelker, J. Brachmann, F. Weidemann, G. Ertl, M. Jones, N. Searle, M. Cocker, E. Ilsley, P. Foley, R. Khiani, K. E. Nelson, A. J. Turley, W. A. Owens, S. A. James, N. J. Linker, V. Velagic, M. Cikes, B. Pezo Nikolic, D. Puljevic, J. Separovic-Hanzevacki, M. Lovric-Bencic, B. Biocina, D. Milicic, H. Kawata, L. Chen, H. Phan, K. Anand, G. Feld, U. Birgesdotter-Green, I. Fernandez Lozano, C. Mitroi, J. Toquero Ramos, V. Castro Urda, V. Monivas Palomero, A. Corona Figueroa, L. Hernandez Reina, L. Alonso Pulpon, A. Gate-Martinet, A. Da Costa, P. Rouffiange, A. Cerisier, L. Bisch, C. Romeyer-Bouchard, K. Isaaz, M.- A. Morales, E. Bianchini, U. Startari, F. Faita, T. Bombardini, V. Gemignani, M. Piacenti, S. Adhya, R. H. Kamdar, L. M. Millar, C. Burchardt, F. D. Murgatroyd, D. Klug, C. Kouakam, L. Guedon-Moreau, C. Marquie, S. Benard, S. Kacet, N. Cortez-Dias, P. Carrilho-Ferreira, D. Silva, S. Goncalves, M. Valente, P. Marques, L. Carpinteiro, J. Sousa, T. Keida, T. Nishikido, M. Fujita, T. Chinen, T. Kikuchi, K. Nakamura, H. Ohira, M. Takami, D. Anjo, A. Meireles, C. Gomes, C. Roque, A. Pinheiro Vieira, V. Lagarto, H. Reis, S. Torres, D. F. Ortega, L. D. Barja, J. P. Montes, E. Logarzo, P. Bonomini, N. Mangani, C. Paladino, T. Chwyczko, E. Smolis-Bak, M. Sterlinski, M. Pytkowski, B. Firek, A. Jankowska, H. Szwed, I. Nakajima, T. Noda, H. Okamura, K. Satomi, T. Aiba, W. Shimizu, N. Aihara, S. Kamakura, W. Brzozowski, A. Tomaszewski, A. Wysokinski, E. G. Bertoldi, L. E. Rohde, L. I. Zimerman, M. Pimentel, C. A. Polanczyk, G. Boriani, M. Lunati, M. Gasparini, M. Landolina, G. Lonardi, D. Pecora, M. Santini, S. Valsecchi, B. J. Rubinstein, D. Y. Wang, S. E. Cabreriza, M. E. Richmond, A. Rusanov, T. A. Quinn, B. Cheng, H. M. Spotnitz, H. M. Kristiansen, G. Vollan, T. Hovstad, H. Keilegavlen, S. Faerestrand, U. Brigesdotter-Green, A. M. R. Nawar, D. A. L. I. A. Ragab, R. A. N. I. A. Eluhsseiny, A. H. M. E. D. Abdelaziz, E. Nof, R. Abu Shama, J. Buber, R. Kuperstein, M. S. Feinberg, D. Barlev, M. Eldar, M. Glikson, H. Badran, R. Samir, M. Tawfik, M. Amin, H. Eldamnhoury, S. Khaled, J. M. Tolosana, A. M. Martin, A. Hernandez-Madrid, A. Macias, I. Fernandez-Lozano, J. Osca, A. Quesada, L. Padeletti, G. L. Botto, T. De Santo, A. Szwed, J. G. Martinez, B. Degand, G. Q. Villani, C. Leclercq, P. Ritter, I. Watanabe, K. Nagashima, Y. Okumura, M. Kofune, K. Ohkubo, T. Nakai, A. Hirayama, E. Mikhaylov, M. Vander, D. Lebedev, M. Zarse, H. Suleimann, H. Bogossian, J. Stegelmeyer, I. Ninios, Z. Karosienne, A. Kloppe, B. Lemke, S. John, T. Gaspar, S. Rolf, P. Sommer, G. Hindricks, C. Piorkowski, J. Fernandez-Armenta, L. L. Mont, H. Zeljko, D. Andreu, C. Herzcku, T. Boussy, J. Brugada, T. Obayahi, J. Hegrenes, E. Lim, V. Mediratta, R. Bautista, L. Teplitsky, C. F. B. Van Huls Van Taxis, A. P. Wijnmaalen, M. Gawrysiak, J. D. Schuijf, J. J. Bax, Y. Huo, S. Richter, A. Arya, A. Bollmann, F. Akca, T. Bauernfeind, B. Schwagten, N. M. S. De Groot, L. Jordaens, T. Szili-Torok, S. Miller, G. Kastner, P. Maury, P. Della Bella, E. Delacretaz, F. Sacher, G. Maccabelli, R. Brenner, A. Rollin, P. Jais, P. Vergara, N. Trevisi, A. Ricco, F. Petracca, C. Bisceglia, F. Baratto, R. Salguero Bodes, A. Fontenla Cerezuela, M. De Riva Silva, M. Lopez Gil, E. Mejia Martinez, A. Jurado Roman, M. Montero Alvarez, F. Arribas Ynsaurriaga, A. Baszko, K. Krzyzanowski, W. Bobkowski, R. Surmacz, E. Zinka, A. Siwinska, A. Szyszka, A. Perez Silva, A. Estrada Mucci, M. Ortega Molina, J. L. Lopez Sendon, J. L. Merino Llorens, K. Kaitani, K. Hanazawa, C. Izumi, Y. Nakagawa, I. Yamanaka, T. Hirahara, Y. Sugawara, C. Suga, J. Ako, S. Momomura, N. Galizio, J. Gonzalez, F. Robles, A. Palazzo, L. Favaloro, M. Diez, E. Guevara, A. Fernandez, S. Greenberg, A. Epstein, D. S. Goldman, C. Sangli, J. A. Keeney, K. Lee, S. R. D. Piers, J. B. Van Rees, J. Thijssen, C. J. W. Borleffs, E. T. Van Der Velde, C. H. Leclercq, M. Hero, M. Mizobuchi, Y. Enjoji, Y. Yazaki, K. Shibata, A. Funatsu, T. Kobayashi, S. Nakamura, G. Amit, B. Pertzov, D. Zahger, L. Medesani, R. Rana, F. Albano, H. Fraguas, S. S. Pedersen, M. T. Hoogwegt, D. A. M. J. Theuns, K. C. Van Den Broek, F. B. Tekle, M. Habibovic, M. Alings, P. Van Der Voort, J. Denollet, H. Vrazic, C. Jilek, H. Lesevic, S. Tzeis, V. Semmler, M. R. Gold, M. C. Burke, G. H. Bardy, N. Varma, B. Pavri, B. Stambler, J. Michalski, T. R. U. S. T. Investigators, E. Safak, D. Schmitz, T. Konorza, C. Wende, A. Schirdewan, J. Neuzner, T. Simmers, A. Erglis, R. Gradaus, J. Goetzke, L. Coutrot, K. Goehl, V. Bazan Gelizo, N. Grau, E. Valles, M. Felez, C. Sanjuas, J. Bruguera, J. Marti-Almor, S. Y. Chu, P. W. Li, W. H. Ding, C. Schukro, L. Leitner, J. Siebermair, G. Stix, T. Pezawas, J. Kastner, M. Wolzt, H. Schmidinger, N. A. T. H. A. L. I. E. Behar, G. Kervio, B. Petit, P. Maison-Balnche, S. Bodi, P. Mabo, P. W. X. Foley, E. Mutch, J. Brashaw-Smith, L. Ball, F. Leyva, D. H. Kim, M. J. Lee, W. S. Lee, S. D. Park, S. H. Shin, S. I. Woo, J. Kwan, K. S. Park, Y. Munetsugu, K. Tanno, M. Kikuchi, H. Ito, F. Miyoshi, M. Kawamura, Y. Kobayashi, S. Man, A. M. Algra, C. A. Schreurs, E. E. Van Der Wall, S. C. Cannegieter, C. A. Swenne, K. Iitsuka, T. Kondo, K. Goebbert, Z. Karossiene, D. Goldman, B. Kallen, E. Kerpi, J. Sardo, P. Arsenos, K. Gatzoulis, G. Manis, P. Dilaveris, D. Tsiachris, D. Mytas, S. Asimakopoulos, C. Stefanadis, S. Sideris, E. Kartsagoulis, O. Barbosa, M. Marocolo Junior, R. Silva Cortes, R. A. Moraes Brandolis, L. F. Oliveira, L. A. Pertili Rodrigues De Resende, M. A. Vieira Da Silva, V. J. Dias Da Silva, R. A. Hegazy, I. A. Sharaf, F. Fadel, H. Bazaraa, R. Esam, M. S. Deshko, V. A. Snezhitsky, T. P. Stempen, K. Kuroki, M. Igawa, K. Kuga, L. Ferreira Santos, T. Dionisio, L. Nunes, J. Machado, S. Castedo, C. Henriques, A. Matos, J. Oliveira Santos, K. Kraaier, M. A. G. M. Olimulder, M. A. Galjee, P. F. H. M. Van Dessel, J. Van Der Palen, A. A. M. Wilde, M. F. Scholten, F. Chouchou, L. Poupard, C. Philippe, I. Court-Fortune, J.- C. Barthelemy, F. Roche, T. S. Dolgoshey, G. A. Madekina, S. Sugiura, E. Fujii, M. Senga, K. Dohi, E. Sugiura, M. Nakamura, M. Ito, C. Eitel, J. Mendell, K. Lasseter, M. Shi, L. Urban, R. Hatala, P. Hlivak, M. De Melis, C. Garutti, G. Corbucci, H. Mlcochova, R. Maxian, E. Arbelo, A. Dogac, C. Luepkes, M. Ploessnig, C. Chronaki, L. Hinterbuchner, A. Guillen, S. S. Bun, D. G. Latcu, F. Franceschi, S. Prevot, L. Koutbi, P. Ricard, N. Saoudi, N. Nazari, A. Alizadeh, S. Sayah, M. Hekmat, M. Assadian, A. Ahmadzadeh, M. Wnuk, J. Jedrzejczyk-Spaho, O. Kruszelnicka, W. Piwowarska, A. Fedorowski, P. Burri, S. Juul-Moller, O. Melander, P. Mitro, P. Murin, P. Kirsch, V. Habalova, E. Slaba, E. Matyasova, M. A. Barlow, R. J. Blake, P. Rostoff, E. Wojewodka Zak, L. Froidevaux, F. P. Sarasin, M. Louis-Simonet, O. Hugli, B. Yersin, J. Schlaepfer, C. Mischler, E. Pruvot, E. Occhetta, F. Frascarelli, A. Burali, and E. Dovellini

Subjects
Oncology, medicine.medical_specialty, business.industry, nutritional and metabolic diseases, medicine.disease, Logistic regression, Breast cancer, Physiology (medical), Internal medicine, medicine, lipids (amino acids, peptides, and proteins), skin and connective tissue diseases, Cardiology and Cardiovascular Medicine, business
Abstract

Results: Out of 664159 women there were 22938 patients with hyperlipidaemia (3.5%) and 9312 patients with breast cancer. Out of the hyperlipidaemia patients, 530 patients developed breast cancer (2.3%) compared with 8782 patients developing breast cancer without hyperlipidaemia (1.4%). A logistic regression model accounting for time from first presentation to development of breast cancer showed that the presence of hyperlipidaemia increases the outcome of breast cancer by 1.64 times (95% C.I. 1.50-1.79). Conclusions: Whilst we appreciate numerous limitations of our methods, coupled with the main findings of the recent basic science research, our analysis further augments the case for the role of cholesterol in the development of breast cancer. Our data from a large clinical relevant sample further strengthens the argument to prospectively trial statins in the management of breast cancer.

Published
2011
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40. L-carnitine in cardiogenic shock therapy: pharmacodynamic aspects and clinical data

Author

G G, Corbucci and F, Loche

Subjects
Hospitalization, Survival Rate, Carnitine, Hemodynamics, Myocardial Infarction, Shock, Cardiogenic, Humans, Pilot Projects, Blood Gas Analysis, Infusions, Intravenous
Abstract

Following our previous work on biochemical and clinical aspects of cardiogenic shock, we carried out an open study on 27 patients hospitalized in shock condition and investigated for the entire period of permanence in intensive care units (ICU). The subjects were treated with high doses of L-carnitine following previous results on the use of this molecule in conditions of oxidative damage due to acute cellular hypoxia. When compared with the data reported in the literature, the results obtained in this study show a surprisingly positive trend for the carnitine-treated patients in terms of survival rate to the cardiogenic shock. This finding and statistical analysis of the clinical parameters confirm the suggestion that L-carnitine could be credited with a new and interesting role in the therapy of cardiogenic shock.

Published
1993

41. Indomethacin and fertility in experimental endometriosis

Author

R, Dargenio, M G, Corbucci, M A, Lamanna, and N, Garcea

Subjects
Disease Models, Animal, Pregnancy, Indomethacin, Endometriosis, Prostaglandins, Animals, Female, Rats, Wistar, Infertility, Female, Injections, Intramuscular, Drug Administration Schedule, Peritoneal Neoplasms, Rats
Abstract

Clinical and experimental evidence showed an increased concentration of prostaglandins in peritoneal fluid in cases of endometriosis. The aim of this study was to verify whether an antiprostaglandin drug can restore fertility in cases of endometriosis. For this reason endometriosis was induced in 4 groups of 10 rats. Group A was treated with indomethacin both in the pre-ovulatory and in the post-ovulatory phase. Group B was treated in the pre-ovulatory phase. Group C was treated in the post-ovulatory phase. Group D was not treated. Ten other rats (group E) underwent a sham operation and were used as a control. Twelve days after mating, gestational sacs and corpora lutea were counted and the nidation index was calculated. Only indomethacin administered during the pre-ovulatory phase completely restored fertility in these rats.

Published
1992

42. Influence of acetyl-carnitine on some mitochondrial enzymic activities in the human cerebral tissue in conditions of acute hypoxia

Author

G G, Corbucci, A, Melis, M, Piga, A, Marchionni, and M, Calvani

Subjects
Adult, Male, Succinate Dehydrogenase, L-Lactate Dehydrogenase, Acute Disease, Humans, Pyruvate Dehydrogenase Complex, Acetylcarnitine, Hypoxia, Brain, Mitochondria
Abstract

Following previous research on human tissue in conditions of acute and massive hypoxia, in the present work the authors compared the cellular enzymic response to oxidative stress in normoxic (perifocal) and hypoxic (focal) areas in human brain affected by regional acute vasculopathies. Two homogeneous groups of patients were selected following strict clinical inclusion/exclusion criteria. The groups of patients were treated with a placebo or acetyl-carnitine at same doses and following randomized, double-blind procedures. The focal areas showed a significant functional damage in lactate, pyruvate and succinate dehydrogenases and in the cytochrome oxidase activity when compared with the enzymic capacities of perifocal areas (normoxic as controls). The pretreatment with acetyl-carnitine antagonized the above-mentioned enzymic damage by a protective action linked to the endocellular energy restoration. In accordance with these data, the therapeutic role played by acetyl-carnitine in the cerebral focal hypoxia appeared to be a determinant for the cell survival mainly in the reversible phase of oxidative damage.

Published
1992

43. Metabolic aspects of acute cerebral hypoxia during extracorporeal circulation and their modification induced by acetyl-carnitine treatment

Author

G G, Corbucci, A, Menichetti, A, Cogliatti, P, Nicoli, A, Arduini, W, Damonti, A, Marchionni, and M, Calvani

Subjects
Extracorporeal Circulation, Cardiopulmonary Bypass, Hemodynamics, Succinates, Double-Blind Method, Fumarates, Acute Disease, Lactates, Humans, Tyrosine, Anesthesia, Acetylcarnitine, Hypoxia, Brain, Pyruvates, Glycolysis
Abstract

Following their previous research experiences in human tissue hypoxia, in the present study the authors. investigated the metabolic effects of acute brain hypoxia in a group of patients in course of extracorporeal circulation for aorto-pulmonary bypass. One hundred subjects were treated, half with a placebo and half with acetyl-carnitine to evaluate the effects of oxidative stress in some brain plasmatic metabolites and to verify the effect of acetyl-carnitine on the tissue energy capacity. The levels of lactate, pyruvate, succinate and fumarate showed a significant imbalance due to hypoxia, while the acetyl-carnitine treatment confined the metabolic gradients within physiological limits. This means that during the course of extracorporeal circulation brain hypoxia plays a pathological role assuming the typical picture of cellular oxidative damage and the acetyl-carnitine antagonizes these deleterious effects of hypoxia by a protective mechanism on the energy processes and then on the cellular enzymic activities. In this regard, the d-tyrosine levels, considered as a proteolytic index, confirm the action of acetyl-carnitine on the cell morpho-functional integrity.

Published
1992

44. Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment

Author

G G, Corbucci, A, Menichetti, A, Cogliatti, P, Nicoli, and C, Ruvolo

Subjects
Male, Extracorporeal Circulation, Sodium, Succinic Acid, Succinates, Middle Aged, Bicarbonates, Random Allocation, Sodium Bicarbonate, Double-Blind Method, Fumarates, Carnitine, Lactates, Humans, Female, Lactic Acid, Hypoxia, Pyruvates
Abstract

In this study the authors examine the effects of acute hypoxia due to extracorporeal circulation (ECC) and the role played by L-carnitine treatment on some plasmatic metabolites linked to glycolytic cellular metabolism. To obtain biochemical data, 120 patients in extracorporeal circulation during aortopulmonary bypass surgery were evaluated. The patients received either sodium bicarbonate (40 patients), or L-carnitine during ECC (40 patients) or before and during ECC (40 patients), and plasma samples were collected before ECC, during ECC and after ECC. The levels of lactate and pyruvate showed significant alterations in sodium bicarbonate-treated patients, and there was also a considerable imbalance in the succinate/fumarate ratio. This means that tissue hypoxia due to ECC leads to cellular oxidative damage and to a considerable decrease in the intracellular energy pools. The use of L-carnitine antagonizes the oxidative stress, as is well documented by the levels of plasmatic metabolites which remain confined to normal amounts.

Published
1992

45. Poster Session 4: Syncope

Author

M. Wnuk, H. Abe, E. K. Kramarz, J. Kowalczyk, S. Favale, S. Sideris, C. Stefanadis, P. Mitro, G. Karystinos, G. Nur-Mammadova, Y. Otsuji, V. Peppes, M. Maciel, W. Mazurek, A. Santos, P. Cooper, E. Konduracka, C. Forleo, R. M. Santos, A. Stanczyk, L. Gianfranchi, M. L. Sturmer, S. Rose, T. Gialernios, R. Maggi, T. L. L. Leiria, P. Guida, F. Ayala-Paredes, S. Sorrentino, R. Chirife, T. Tahir, R. Candeias, B. Godin, D. Zysko, C. Garratt, S. Cebula, D. Kontomerkos, G. Corbucci, T. Kus, A. Musialik-Lydka, A. Sedkowska, A. Antoniou, H. Sotiropoulos, J. Silva, A. Fitzpatrick, M. Nogues, M. Dimopoulos, P. Kirsch, M. Iacoviello, E. Wojewodka-Zak, F. Boomsma, J. P. Freitas, A. Z. Pietrucha, D. Mroczek-Czernecka, K. Gatzoulis, I. Mustafaev, H. Grancelli, M. Dinelli, I. Bzukala, M. Panunzio, J. Gajek, W. Piwowarska, V. Gomes, B. Clarke, S. Petkar, Z. Kalarus, R. Kohno, C. Tentori, I. Jesus, N. Marques, L. U. K. Olendrzynski, P. Alboni, T. Parisi, P. Arsenos, B. Sredniawa, G. A. Ruiz, L. K. Kubik, P. Dilaveris, A. Wozniak, V. D'andria, A. Sliwinska, G. Fuca, A. Lemieux, and M. M. Ciccone

Subjects
medicine.medical_specialty, biology, business.industry, Physiology (medical), Syncope (genus), Physical therapy, Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business, biology.organism_classification
Published
2009
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46. Influence of acetyl-L-carnitine infusion on haemodynamic parameters and survival of circulatory-shock patients

Author

A, Gasparetto, G G, Corbucci, R A, De Blasi, M, Antonelli, E, Bagiella, S, D'Iddio, and C, Trevisani

Subjects
Adult, Adolescent, Hemodynamics, Shock, Cardiogenic, Shock, Middle Aged, Shock, Septic, Blood Pressure Monitors, Survival Rate, Intensive Care Units, Double-Blind Method, Humans, Shock, Traumatic, Acetylcarnitine, Infusions, Intravenous, Aged
Abstract

The clinical use of acetyl carnitine in circulatory shock has its theoretical basis in the ability of this molecule to restore enzyme activity inhibited by hypoxia, acting as an acetyl donor. Moreover the action of carnitine on an injured myocardium encouraged us to examine the clinical effect of this drug during heart failure. A double-blind clinical study was performed in ten Italian intensive care units on 115 patients with septic, cardiac of traumatic shock, by using acetyl-L-carnitine infusion for 12 hours, with a previous single bolus intravenously. The results showed a good response to the drug in terms of blood oxygenation during the course of sepsis and heart failure. The heart rate as well as right atrial pressure decreased significantly in patients with cardiogenic shock. In septic patients systolic and mean arterial pressures increased also. The present data suggests the use of acetyl-L-carnitine as an adjuvant to the commonly used therapy in hypoxic conditions.

Published
1991

47. Cardiogenic shock and L-carnitine: clinical data and therapeutic perspectives

Author

G G, Corbucci and B, Lettieri

Subjects
Adult, Male, Carnitine, Shock, Cardiogenic, Humans, Female, Middle Aged, Hypoxia, Oxidation-Reduction, Aged
Abstract

Research experiences on the use of L-carnitine in conditions of acute hypoxia underline the protective role of this molecule on the cellular enzymic complex. To obtain unconfutable clinical data at this regard, the survival rate in two groups of patients affected by cardiogeic shock was evaluated. The first group (80 patients) was treated with L-carnitine while the second group (36 patients) received sodium bicarbonate. The results showed a significant response to L-carnitine treatment, indicating the role of this molecule on the metabolic acidosis due to shock. The sum of these data confirmed the role of L-carnitine in the reversible phase of cardiogenic shock in terms of enzymic protection in the course of cellular oxidative damage.

Published
1991

48. [Neoplastic occlusion of the right colon]

Author

G, Corbucci Vitolo, B, Nardo, G, Manara, G, Pagliani, A, Cunsolo, and G, Gozzetti

Subjects
Adult, Aged, 80 and over, Male, Palliative Care, Adenocarcinoma, Middle Aged, Colonic Neoplasms, Cecal Diseases, Humans, Female, Emergencies, Colectomy, Intestinal Obstruction, Aged
Abstract

On the basis of more than 10 years' clinical experience of 122 patients operated on for cancer of the right colon, stress is laid on intestinal occlusion which is one of the most frequent complications of this pathology. The factors that make the event to be avoided and that lead to the poor short and long-term results are analysed.

Published
1990

49. Metabolic effects induced by L-carnitine and propionyl-L-carnitine in human hypoxic muscle tissue during exercise

Author

G G, Corbucci, G, Montanari, G, Mancinelli, and S, D'Iddio

Subjects
Lipid Peroxides, Time Factors, Carnitine, Muscles, Physical Exertion, Humans, Hypoxia
Abstract

An experimental model was developed to investigate some metabolic effects of strenuous exercise in hypoxic muscle tissue of human volunteers. The incidence of carnitine supplementation was studied, assuming as marker the thiobarbituric acid reaction products analysed in plasma samples collected during the course of the protocol programme. Propionyl-L-carnitine appears to antagonize in a significant degree the damaging effects of muscle fatigue combined with hypoxic status. Under these conditions the detoxifying role played by propionyl-L-carnitine, previously reported in various tissues and in other pathological conditions, appears to be relevant, although further studies are needed to elucidate the pharmacodynamics of this molecule.

Published
1990

50. The role of reduced glutathione during the course of acute haemolysis in glucose-6-phosphate dehydrogenase deficient patients: clinical and pharmacodynamic aspects

Author

G G, Corbucci

Subjects
Adult, Male, Adolescent, Alanine Transaminase, Favism, gamma-Glutamyltransferase, Middle Aged, Glutathione, Hemolysis, Cell Hypoxia, Uric Acid, Glucosephosphate Dehydrogenase Deficiency, Double-Blind Method, Lactates, Humans, Aspartate Aminotransferases, Lactic Acid, Oxidation-Reduction
Abstract

Tissue hypoperfusion leads to cellular oxidative and peroxidative damage due to biochemical disorders in the oxygen and substrate metabolism. The metabolic turnover of glutathione (GSH) represents one the main cytoprotective systems against the peroxide attack and the depletion or defect in resynthesis of this compound is accompanied by pathological consequences. In the present study the clinical effects of glutathione depletion were investigated in conditions of acute tissue hypoxia due to marked haemolysis in glucose-6-phosphate dehydrogenase deficient patients (favism syndrome). In these subjects a significant marker of the tissue oxidative damage was represented by the uric acid blood levels, presumably linked to xanthine-hypoxanthine altered metabolism. To antagonize the effects of oxyradical pathology, reduced glutathione was administered to a group of patients and the results confirmed the cytoprotective role played by the GSH supplementation. The GSH action was evident on the tissue metabolism and this supports the opinion that reduced glutathione could represent a new and interesting therapeutic approach in marked and acute hypoxic conditions.

Published
1990

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