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1. Derivation and validation of Re.Co.De death score risk in patients with acute nonvariceal upper GI bleeding

Author

L, Amitrano, A, Andriulli, V, Annese, G, Baldassarre, S, Bargiggia, A, Balzano, F, Bazzoli, R, Bennato, M A, Bianco, A, Bizzotto, V, Boarino, AG, Bonanomi, P, Borgheresi, G, Bresci, F, Buffoli, E, Buscarini, G, Castrignanò, LG, Cavallaro, P, Cesaro, A, Chirico, F, Cipolletta, L, Cipolletta, R, Conigliaro, D, Conte, G, Costamagna, G, D’ Amico, C, De Fanis, FR, De Filippo, R, de Franchis, A, Dell‘ Era, F, De Nigris, M, De Matthaeis, P, Di Giorgio, E, Di Giulio, P, Esposito, L, Ferraris, A, Filippino, M, Franceschi, L, Furio, B, Germana, R, Grassia, G, Imperiali, R, Lamanda, A, Lauri, C, Londoni, S, Mangiafico, M, Manno, C, Marmo, R, Meroni, S, Metrangolo, M, Montalbano L., G, Napolitano, A, Nucci, L, Orsini, F, Parente, M, Parravicini, A, Paterlini, R, Pumpo, L, Purita, A, Repici, ME, Riccioni, A, Russo, S, Segato, I, Sorrentino, G, Spinzi, D, Spotti, A, Tortora, O, Triossi, RM, Zagari, A, Zambelli, Marmo, Riccardo, Soncini, Marco, Bucci, Cristina, Occhipinti, Vincenzo, Pellegrini, Lucienne, and Zullo, Angelo

Published
2022
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2. Derivation and validation of Re.Co.De death score risk in patients with acute nonvariceal upper GI bleeding

Author

Marmo, Riccardo, primary, Soncini, Marco, additional, Bucci, Cristina, additional, Occhipinti, Vincenzo, additional, Pellegrini, Lucienne, additional, Zullo, Angelo, additional, L, Amitrano, additional, A, Andriulli, additional, V, Annese, additional, G, Baldassarre, additional, S, Bargiggia, additional, A, Balzano, additional, F, Bazzoli, additional, R, Bennato, additional, M A, Bianco, additional, A, Bizzotto, additional, V, Boarino, additional, AG, Bonanomi, additional, P, Borgheresi, additional, G, Bresci, additional, F, Buffoli, additional, E, Buscarini, additional, G, Castrignanò, additional, LG, Cavallaro, additional, P, Cesaro, additional, A, Chirico, additional, F, Cipolletta, additional, L, Cipolletta, additional, R, Conigliaro, additional, D, Conte, additional, G, Costamagna, additional, G, D’ Amico, additional, C, De Fanis, additional, FR, De Filippo, additional, R, de Franchis, additional, A, Dell‘ Era, additional, F, De Nigris, additional, M, De Matthaeis, additional, P, Di Giorgio, additional, E, Di Giulio, additional, P, Esposito, additional, L, Ferraris, additional, A, Filippino, additional, M, Franceschi, additional, L, Furio, additional, B, Germana, additional, R, Grassia, additional, G, Imperiali, additional, R, Lamanda, additional, A, Lauri, additional, C, Londoni, additional, S, Mangiafico, additional, M, Manno, additional, C, Marmo, additional, R, Meroni, additional, S, Metrangolo, additional, M, Montalbano L., additional, G, Napolitano, additional, A, Nucci, additional, L, Orsini, additional, F, Parente, additional, M, Parravicini, additional, A, Paterlini, additional, R, Pumpo, additional, L, Purita, additional, A, Repici, additional, ME, Riccioni, additional, A, Russo, additional, S, Segato, additional, I, Sorrentino, additional, G, Spinzi, additional, D, Spotti, additional, A, Tortora, additional, O, Triossi, additional, RM, Zagari, additional, and A, Zambelli, additional

Published
2022
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3. The 'Hub and Spoke' model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Cristina Bucci, L. Amitrano, C. Londoni, A. Chirico, O. Triossi, A. Zambelli, F. Bazzoli, B. Germanà, F. Cipolletta, Marco Soncini, S. Mangiafico, F. Parente, E Di-Giulio, A. Andriulli, G. D'Amico, G. Baldassarre, Riccardo Marmo, A. Repici, A. Paterlini, G. Imperiali, Angelo Zullo, V Annese, F. De Nigris, R. Bennato, S. Metrangolo, L. Orsini, S. Bargiggia, I Sorrentino, M. Manno, Maria Elena Riccioni, C. Tomba, A. Nucci, A. Bizzotto, FR De-Filippo, A. Merighi, Guido Costamagna, R de-Franchis, C. Marmo, A. Anderloni, L.G. Cavallaro, P Esposito, A. Russo, R. Pumpo, D. Conte, M.A. Bianco, F Buffoli, L. Cipolletta, R. Conigliaro, P Di-Giorgio, A Filippino, G. Bresci, F Covello, P. Borgheresi, L.M. Montalbano, R.M. Zagari, E. Buscarini, Annalisa Tortora, D. Spotti, L. Ferraris, R. Lamanda, M. Franceschi, G Castrignanò, G. Spinzi, A. Lauri, S. Segato, R Grassia, V. Boarino, P. Cesaro, C De-Fanis, R. Meroni, G. Napolitano, L. Furio, AG Bonanomi, M De-Matthaeis, M. Parravicini, A Dell‘Era, L. Purita, Marmo R., Soncini M., Bucci C., Zullo A., Amitrano L., Anderloni A., Andriulli A., Annese V., Baldassarre G., Bargiggia S., Bazzoli F., Bennato R., Bianco M.A., Bizzotto A., Boarino V., Bonanomi A.G., Borgheresi P., Bresci G., Buffoli F., Buscarini E., Castrignano G., Cavallaro L.G., Cesaro P., Chirico A., Cipolletta F., Cipolletta L., Conigliaro R., Conte D., Costamagna G., Covello F., D'Amico G., De-Fanis C., De-Filippo F.R., de-Franchis R., Dell'Era A., De Nigris F., De-Matthaeis M., Di-Giorgio P., Di-Giulio E., Esposito P., Ferraris L., Filippino A., Franceschi M., Furio L., Germana' B., Grassia R., Imperiali G., Lamanda R., Lauri A., Londoni C., Mangiafico S., Manno M., Marmo C., Merighi A., Meroni R., Metrangolo S., Montalbano L.M., Napolitano G., Nucci A., Orsini L., Parente F., Parravicini M., Paterlini A., Pumpo R., Purita L., Repici A., Riccioni M.E., Russo A., Segato S., Sorrentino I., Spinzi G., Spotti D., Tortora A., Tomba C., Triossi O., Zagari R.M., and Zambelli A.

Subjects
medicine.medical_specialty, Gastrointestinal bleeding, Multivariate analysis, Organizational model, Improved survival, Comorbidity, 03 medical and health sciences, Organizational setting, 0302 clinical medicine, Health care, Spoke-hub distribution paradigm, Medicine, Humans, Hub and spoke network, Mortality, Aged, Hepatology, business.industry, Delivery of Health Care, Integrated, Gastroenterology, Acute upper gastrointestinal bleeding, Length of Stay, Middle Aged, medicine.disease, Italy, 030220 oncology & carcinogenesis, Case-Control Studies, Emergency medicine, 030211 gastroenterology & hepatology, business, Gastrointestinal Hemorrhage, Acute gastrointestinal bleeding, Cohort study
Abstract

Background: the lack of standardized pathways for patients with gastrointestinal bleeding may have led to differences in their management and inequity to medical care access. The "Hub & Spoke" model was adopted to fill this gap in many disciplines, but, to our knowledge, no data exist on its efficacy on mortality in GI bleeding. We aimed to evaluate if the "Hub & Spoke" organizational model has an impact on mortality risk from UGIB. Methods: from January 2014 to December 2015, 3324 consecutive patients admitted for UGIB in 50 Italian hospitals were enrolled (1977 patients in hospitals within the "Hub & Spoke" network for digestive hemorrhagic emergency and 1347 in hospitals outside the "Hub & Spoke" network). Clinical, endoscopic and organizational data were recorded. Results: we observed no differences in mortality between patients admitted to hospitals included or not included in the "Hub & Spoke" network (5.2% vs 6.1%, p = 0.3). On multivariate analysis, admission in gastroenterology wards (OR 0.61, p = 0.001) or an academic hospital (OR 0.65, p < 0.056) were independent protective factors while being in "Hub & Spoke" organization system did not affect mortality (OR 1.09, p = 0.57). Conclusion: the "Hub & Spoke" model per sé does not impact on mortality while being treated in academic hospital or gastroenterology wards improved survival.

Published
2021

4. Anti-erythroblast autoimmunity in early myelodysplastic syndromes

Author

Wilma Barcellini, Anna Zaninoni, Francesca G. Imperiali, Carla Boschetti, Mariangela Colombi, Alessandra Iurlo, and Alberto Zanella

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Background and Objectives Autoimmune phenomena, mainly directed against red blood cells are described in myelodysplastic syndromes (MDS), particularly early MDS, i.e. refractory anemia (RA) and RA with ringed sideroblasts (RARS). Dysregulation of apoptosis and immunoregulatory cytokines are thought to play a role in the pathogenesis of MDS.Design and Methods This work was aimed to investigate anti-erythroid autoimmunity in unstimulated and mitogen-stimulated peripheral blood and bone marrow cultures of 26 patients with early MDS (RA and RARS), and to relate its presence with apoptotic markers and cytokine production. Bone marrow cytokine production in culture supernatants, and caspase-3 and nuclear factor-κB activity in cell extracts were tested by enzyme-linked immunosorbent assays.Results Fourteen of the 26 (53.8%) patients showed the presence of autoantibodies in bone marrow cultures, whereas none displayed a positive direct antiglobulin test in peripheral blood cultures. Incubation of culture supernatants from positive patients with autologous CD45– enriched-cell suspensions showed that the autoimmune reaction was directed against autologous erythroblasts. These patients had mild signs of hemolysis and increased numbers of erythroblasts, compared with negative patients. Patients with anti-erythroblast autoimmunity displayed higher caspase-3 activity and lower tumor necrosis factor-αand interleukin-4 production than did negative patients.Interpretation and Conclusions Half of the patients with early MDS showed autoimmunity against erythroblasts. This evidence might support a more rationale use of steroid therapy in these patients. The lower levels of cytokines in patients with anti-erythroblast autoimmunity are consistent with the suggested hypothesis that the autoimmune phenomena observed in MDS are probably initiated and perpetuated through alterations of pro-inflammatory and/or immunoregulatory cytokine production.

Published
2007
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5. OC.10.1 THE USE OF PRE-ENDOSCOPIC INTRAVENOUS PROTON PUMP INHIBITORS (PPIS) HAD NO IMPACT ON CLINICAL OUTCOMES IN ACUTE UPPER GASTROINTESTINAL BLEEDING: A PROSPECTIVE MULTICENTER ITALIAN COHORT STUDY

Author

A. Andriulli, R. Pumpo, G. Spinzi, L. Amitrano, G. Baldassarre, Marco Soncini, Riccardo Marmo, M. De Matthaeis, C. Londoni, L. Furio, L. Ferraris, S. Metrangolo, A. Balzano, L.G. Cavallaro, G. D'Amico, A. Lauri, E. Buscarini, V. Boarino, A. Merighi, B. Germanà, D. Spotti, P. Di Giorgio, L. Orsini, G. Imperiali, R. Lamanda, F. De Nigris, Alessandra Dell'Era, S. Bargiggia, D. Conte, F. Cipolletta, A. Nucci, P. Cesaro, A. Bizzotto, F.R. De Filippo, A. Anderloni, Maria Elena Riccioni, C. Marmo, A. Repici, A. Paterlini, A. Chirico, G. Napolitano, S. Mangiafico, C. De Fanis, O. Triossi, G. Rotondano, Annalisa Tortora, Guido Costamagna, F. Esposito, P. Borgheresi, L.M. Montalbano, E. Di Giulio, M. Franceschi, Cristina Bucci, R. Bennato, M. Manno, L. Purita, L. Cipolletta, R. Conigliaro, R.M. Zagari, R. De Franchis, A. Zambelli, F. Bazzoli, A. Russo, M.A. Bianco, G. Bresci, M. Parravicini, F. Parente, and S. Segato

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Acute upper gastrointestinal bleeding, business, Cohort study
Published
2020
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6. T01.01.7 THE USE OF A SPECIALIZED BLEEDING-MANAGEMENT TEAM HAD NO IMPACT ON MORTALITY FOR ACUTE UPPER GASTROINTESTINAL BLEEDING: AN ITALIAN PROSPECTIVE MULTICENTER COHORT STUDY

Author

L. Purita, S. Segato, L. Ferraris, G. D'Amico, E. Buscarini, G. Imperiali, L. Orsini, F. Parente, Maria Elena Riccioni, P. Borgheresi, L.M. Montalbano, Annalisa Tortora, Guido Costamagna, G. Spinzi, M. Franceschi, S. Mangiafico, A. Balzano, A. Lauri, C. De Fanis, A. Russo, M.A. Bianco, G. Bresci, R.M. Zagari, C. Londoni, A. Andriulli, R. De Franchis, A. Zambelli, F. Bazzoli, L.G. Cavallaro, S. Bargiggia, R. Bennato, D. Conte, M. Manno, F. Esposito, A. Chirico, S. Metrangolo, A. Anderloni, V. Boarino, D. Spotti, O. Triossi, B. Germanà, R. Lamanda, G. Baldassarre, P. Cesaro, M. Parravicini, Cristina Bucci, L. Cipolletta, R. Conigliaro, F. Cipolletta, Alessandra Dell'Era, A. Repici, A. Paterlini, F. De Nigris, G. Napolitano, R. Pumpo, A. Nucci, Marco Soncini, A. Merighi, Riccardo Marmo, A. Bizzotto, F.R. De Filippo, C. Marmo, G. Rotondano, L. Furio, E. Di Giulio, L. Amitrano, M. De Matthaeis, and P. Di Giorgio

Subjects
medicine.medical_specialty, Hepatology, business.industry, Emergency medicine, Gastroenterology, Medicine, Acute upper gastrointestinal bleeding, business, Cohort study
Published
2020
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8. OC.11.5 TRIGGER AND TARGET TRANSFUSION STRATEGY IN PATIENTS WITH NON-VARICEAL ACUTE UPPER GASTROINTESTINAL BLEEDING (NV-AUGIB): A PROSPECTIVE MULTICENTRE OBSERVATIONAL STUDY

Author

L. Amitrano, C. Spada, L. Purita, R. Pumpo, L. Furio, L. Orsini, S. Metrangolo, M. Parravicini, G. D'Amico, F. Esposito, G. Spinzi, R. Bennato, A. Andriulli, A. Merighi, M. Manno, L. Cipolletta, R. Conigliaro, Alessandra Dell'Era, Maria Elena Riccioni, G. Imperiali, A. Lauri, D. Conte, V. Boarino, Guido Costamagna, G. Napolitano, E. Buscarini, G. Baldassarre, P. Cesaro, Cristina Bucci, R. Lamanda, A. Balzano, A. Anderloni, P. Borgheresi, L.M. Montalbano, S. Mangiafico, C. Londoni, A. Russo, C. De Fanis, F. Cipolletta, L. Ferraris, R. De Franchis, A. Zambelli, M.A. Bianco, F. Bazzoli, G. Bresci, L.G. Cavallaro, A. Repici, A. Chirico, O. Triossi, F. Parente, Marco Soncini, Riccardo Marmo, S. Segato, R.M. Zagari, M. De Matthaeis, P. Di Giorgio, F. De Nigris, A. Nucci, A. Bizzotto, F.R. De Filippo, C. Marmo, E. Di Giulio, B. Germanà, G. Rotondano, S. Bargiggia, P. Gasparini, Annalisa Tortora, and M. Franceschi

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Observational study, In patient, Acute upper gastrointestinal bleeding, business
Published
2019
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9. Predictors of favourable outcome in non-variceal upper gastrointestinal bleeding: Implications for early discharge?

Author

Angelo Dezi, Salvatore Tronci, Alessandro Casadei, F. Giangregorio, Tommaso Ceglia, Nicola Pandolfo, Giuseppe Chianese, Giovanni Aragona, I. Stroppa, Riccardo Marmo, R. Macchiarelli, Giorgio Chiozzini, Paolo Giorgio, A. Buzzi, Paola Romagnoli, Francesca Rogai, Anna Tanzilli, Angelo Pera, Mario Salvagnini, L. Pietrini, Renato Fasoli, S. Boschetto, Fabio Fornari, Giorgio Minoli, Livio Cipolletta, W. Piubello, Giampiero Bagnalasta, Sergio Segato, Daniela Di Muzio, Lisa Girardi, G. Frosini, U. Germani, Fabrizio Bonfante, Claudio Cortini, G. Trallori, Sirio Bagnoli, Renzo Cestari, Maria Antonia Bianco, Roberto Di Mitri, Elena Sainz Torre, Salvatore De Stefano, G. Imperiali, G. Gatto, Paolo Michetti, V. Peri, M. Pagliarulo, Amuso M, Rodolfo Rocca, Luciano Allegretta, Gianluca Rotondano, Sergio Brunati, O. Triossi, Andrea Nucci, Tino Casetti, Ivano Lorenzini, Domenico Della Casa, Marco Martorano, F. Barberani, I. Sorrentini, Massimo Proietti, Alfredo Pastorelli, Alessandro Gigliozzi, Marino Di Cicco, Enzo Grossi, Maurizio Koch, Claudio Leoci, Maria Tebaldi, and Barbara Ferri

Subjects
Male, medicine.medical_specialty, Gastrointestinal bleeding, Multivariate analysis, Adverse outcomes, Stomach Diseases, Esophageal Diseases, Risk Assessment, Outcome (game theory), Recurrence, Internal medicine, medicine, Humans, Blood Transfusion, Endoscopy, Digestive System, Prospective Studies, Early discharge, Aged, Aged, 80 and over, Aspirin, Hepatology, business.industry, Hemostasis, Endoscopic, Age Factors, Gastroenterology, Middle Aged, Prognosis, medicine.disease, Patient Discharge, Surgery, Treatment Outcome, ROC Curve, Multivariate Analysis, Female, Upper gastrointestinal bleeding, Gastrointestinal Hemorrhage, Risk assessment, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract

There is a lack of validated predictors on which to decide the timing of discharge in patients already hospitalized for upper nonvariceal bleeding.Identify factors that appear to protect nonvariceal bleeders from the development of negative outcome (rebleeding, surgery, death).Secondary analysis of two prospective multicenter studies. Multivariate analyses for each investigated outcome were performed; a single model was developed including all factors that were statistically significant in each sub-model. A final score was developed to predict favourable outcomes. Prognostic accuracy was tested with ROC curve analysis.Out of 2398 patients, 211 (8.8%) developed one or more adverse outcomes: 87 (3.63%) had rebleeding, 46 (1.92%) needed surgery and 107 (4.46%) died. Predictors of favourable prognosis were: ASA score 1 or 2, absence of neoplasia, outpatient bleeding, use of low-dose aspirin, no need for transfusions, clean-based ulcer, age70 years, no haemodynamic instability successful endoscopic diagnosis/therapy, no Dieulafoy's lesion at endoscopy, no hematemesis on presentation and no need for endoscopic treatment. Overall prognostic accuracy of the model was 83%. The final score accurately identified 20-30% of patients that eventually do not develop any negative outcome.The "good luck score" may be a useful tool in deciding when to discharge a patient already hospitalized for acute non-variceal bleeding.

Published
2014
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10. OC.14.2 PREDICTIVE FACTORS OF MORTALITY IN ACUTE GASTROINTESTINAL BLEEDING IN ITALY (AUGIB): A NEW PRE-ENDOSCOPY PROGNOSTIC MODEL FROM A MULTICENTER STUDY

Author

R. Bennato, M. Manno, S. Segato, M. De Matthaeis, L.G. Cavallaro, E. Buscarini, G. D'Amico, P. Di Giorgio, A. Balzano, G. Imperiali, R. De Franchis, A. Zambelli, F. Bazzoli, Guido Costamagna, F. De Nigris, F. Esposito, A. Andriulli, G. Spinzi, A. Nucci, B. Germanà, L. Ferraris, A. Bizzotto, F.R. De Filippo, V. Boarino, Cristina Bucci, C. Marmo, L. Amitrano, L. Orsini, Marco Soncini, Riccardo Marmo, P. Cesaro, R.M. Zagari, F. Parente, Maria Elena Riccioni, R. Lamanda, A. Anderloni, P. Borgheresi, L.M. Montalbano, E. Di Giulio, A. Lauri, S. Mangiafico, A. Russo, S. Metrangolo, R. Pumpo, C. De Fanis, M.A. Bianco, L. Purita, G. Bresci, A. Chirico, O. Triossi, F. Cipolletta, L. Cipolletta, R. Conigliaro, C. Londoni, A. Repici, A. Paterlini, A. Merighi, M. Parravicini, D. Conte, G. Baldassarre, L. Furio, G. Napolitano, A. Dell'Eera, G. Rotondano, Annalisa Tortora, M. Franceschi, S. Bargiggia, and P. Gasparini

Subjects
medicine.medical_specialty, Hepatology, Multicenter study, medicine.diagnostic_test, Acute gastrointestinal bleeding, business.industry, Internal medicine, Gastroenterology, Prognostic model, medicine, business, Endoscopy
Published
2018
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11. P.10.8: Mortality from Acute Upper Gastrointestinal Bleeding (UGIB): The Role of the Organizational and Health Care Course: A Prospective Multicentre Observational Study in Italy

Author

L. Purita, L. Orsini, S. Mangiafico, S. Segato, C. De Fanis, Maria Elena Riccioni, M. Parravicini, L. Furio, F. De Nigris, Cristina Bucci, A. Andriulli, C. Londoni, Guido Costamagna, E. Buscarini, A. Russo, M.A. Bianco, G. Baldassarre, A. Merighi, L. Ferraris, F. Zingone, A. Nucci, B. Germanà, G. Bresci, R. Pumpo, F. Cipolletta, S. Bargiggia, A. Bizzotto, F.R. De Filippo, C. Marmo, A. Repici, F. Esposito, P. Gasparini, R. Bennato, M. Manno, Marco Soncini, A. Chirico, G. Rotondano, G. Spinzi, A. Anderloni, Riccardo Marmo, D. Conte, G. D'Amico, O. Triossi, V. Boarino, A. Lauri, P. Cesaro, S. Metrangolo, A. Balzano, G. Imperiali, P. Borgheresi, L.M. Montalbano, L.G. Cavallaro, M. De Matthaeis, Alessandra Dell'Era, Annalisa Tortora, M. Guardascione, R.M. Zagari, M. Franceschi, L. Cipolletta, R. Conigliaro, P. Di Giorgio, G. Napolitano, R. De Franchis, A. Zambelli, F. Bazzoli, R. Lamanda, and F. Parente

Subjects
medicine.medical_specialty, Hepatology, business.industry, Health care, Gastroenterology, medicine, Observational study, Acute upper gastrointestinal bleeding, Intensive care medicine, business
Published
2017
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12. P.10.10: Mortality Causes from Acute Upper Gastrointestinal Bleeding: A Prospective Multicentre Observational Study

Author

S. Segato, M. De Matthaeis, F. Cipolletta, V. Boarino, A. Repici, A. Paterlini, G. Spinzi, P. Di Giorgio, L. Orsini, P. Cesaro, G. D'Amico, L. Cipolletta, R. Conigliaro, F. De Nigris, G. Imperiali, R. Bennato, A. Lauri, A. Anderloni, Maria Elena Riccioni, Alessandra Dell'Era, A. Nucci, A. Bizzotto, F.R. De Filippo, B. Germanà, M. Manno, C. Marmo, F. Esposito, Guido Costamagna, G. Napolitano, R. Pumpo, R.M. Zagari, A. Russo, L. Furio, A. Balzano, L. Ferraris, M.A. Bianco, E. Di Giulio, G. Bresci, S. Mangiafico, F. Parente, C. De Fanis, L. Purita, S. Bargiggia, Marco Soncini, G. Rotondano, Riccardo Marmo, A. Merighi, M. Parravicini, P. Borgheresi, L.M. Montalbano, M. Guardascione, P. Gasparini, R. De Franchis, A. Zambelli, F. Bazzoli, E. Buscarini, S. Metrangolo, D. Conte, R. Lamanda, G. Baldassarre, Annalisa Tortora, M. Franceschi, A. Andriulli, L.G. Cavallaro, C. Londoni, Cristina Bucci, A. Chirico, and O. Triossi

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Observational study, Acute upper gastrointestinal bleeding, business
Published
2017
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13. OC.05.2 OLGA – BASED STAGING AND DYSPLASIA RELEVANCE IN 50–75 YEAR OLD PATIENTS IN OPEN ACCESS ENDOSCOPY

Author

Alida Andrealli, Nicoletta Lenoci, Franco Radaelli, G. Imperiali, G. Mandelli, Silvia Paggi, Giancarlo Spinzi, Emanuele Rondonotti, Natalia Terreni, Giuseppe Mogavero, and Arnaldo Amato

Subjects
Old patients, medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Dysplasia, General surgery, Gastroenterology, Medicine, Relevance (information retrieval), business, medicine.disease, Endoscopy
Published
2018
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14. P.03.10 LINKED COLOR IMAGING (LCI) REDUCES THE MISS RATE OF NEOPLASTIC LESIONS IN THE RIGHT COLON: A RANDOMIZED TANDEM COLONOSCOPY STUDY

Author

Arnaldo Amato, Giancarlo Spinzi, Emanuele Rondonotti, Giuseppe Mogavero, G. Imperiali, Silvia Paggi, Franco Radaelli, G. Mandelli, Alida Andrealli, Natalia Terreni, and Nicoletta Lenoci

Subjects
Miss rate, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Medicine, Color imaging, Radiology, business, Colonoscopy Study
Published
2018
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15. Predictive Factors of Mortality From Nonvariceal Upper Gastrointestinal Hemorrhage: A Multicenter Study

Author

Lisa Girardi, Elena S. Torre, Angelo Dezi, Alfredo Pastorelli, Paola Romagnoli, Giampiero Bagnalasta, Marco Martorano, Giovanni Di Matteo, Lucio Capurso, Andrea Nucci, Mariano Amuso, Claudio Leoci, Maria Tebaldi, Anna Tanzilli, G. Imperiali, Paolo Michetti, Rodolfo Rocca, Luciano Allegretta, Claudio Cortini, Renzo Cestari, Giovanni Aragona, Giuseppe Chianese, Domenico Della Casa, Giorgio Minoli, F. Barberani, A. Buzzi, W. Piubello, Paolo Giorgio, Sergio Brunati, Angelo Pera, Livio Cipolletta, Sergio Segato, Fabrizio Bonfante, Omero Triossi, Salvatore Tronci, F. Giangregorio, Gianluca Rotondano, Ivano Lorenzini, Renato Fasoli, Maurizio Koch, Maria A. Bianco, Giorgio Chiozzini, Alessandro Casadei, S. Boschetto, U. Germani, G. Gatto, Francesca Rogai, Riccardo Marmo, Mario Salvagnini, and Massimo Proietti

Subjects
Male, Gastrointestinal bleeding, medicine.medical_specialty, Health Status, MEDLINE, Comorbidity, Hemoglobins, Recurrence, Internal medicine, Epidemiology, medicine, Humans, Upper gastrointestinal, Endoscopy, Digestive System, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, Hepatology, medicine.diagnostic_test, business.industry, Age Factors, Gastroenterology, Middle Aged, medicine.disease, Surgery, Endoscopy, Italy, Multicenter study, Regression Analysis, Female, Gastrointestinal Hemorrhage, business
Abstract

From an Italian Registry of patients with upper gastrointestinal hemorrhage (UGIH), we assessed the clinical outcomes and explored the roles of clinical, endoscopic, and therapeutic factors on 30-day mortality in a real life setting.Prospective analysis of consecutive patients endoscoped for UGIH at 23 community and tertiary care institutions from 2003 to 2004. Covariates and outcomes were defined a priori and 30-day follow-up obtained. Logistic regression analysis identified predictors of mortality.One thousand and twenty patients were included. A total of 46 patients died for an overall 4.5% mortality rate. In all, 85% of deaths were associated with one or more major comorbidity. Sixteen of 46 patients (35%) died within the first 24 h of the onset of bleeding. Of these, eight had been categorized as ASA class 1 or 2 and none of them was operated upon, despite a failure of endoscopic intention to treatment in four. Regression analysis showed advanced age, presence of severe comorbidity, low hemoglobin levels at presentation, and worsening health status as the only independent predictors of 30-day mortality (P0.001). The acute use of a PPI exerted a protective effect (OR 0.23, 95% CI 0.09-0.73). Recurrent bleeding was low (3.2%). Rebleeders accounted for only 11% of the total patients deceased (OR 3.27, 95% CI 1.5-11.2).These results indicate that 30-day mortality for nonvariceal bleeding is low. Deaths occurred predominantly in elderly patients with severe comorbidities or those with failure of endoscopic intention to treatment.

Published
2008
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16. Detection of erythroblast antibodies in mitogen-stimulated bone marrow cultures from patients with myelodysplastic syndromes

Author

Anna, Zaninoni, Francesca G, Imperiali, Alessandra, Cattaneo, Giulia, Soverini, Francesca, Binda, Laura, Porretti, Agostino, Cortelezzi, and Wilma, Barcellini

Subjects
Adult, Aged, 80 and over, Male, Erythroblasts, Apoptosis, Bone Marrow Cells, Middle Aged, Antibodies, Immunoglobulin G, Myelodysplastic Syndromes, Humans, Female, Mitogens, Erythropoietin, Aged
Abstract

Low-risk myelodysplastic syndromes (MDS) show several immunologic abnormalities, including increased frequency of autoimmune manifestations and/or overt autoimmune diseases, whose prognostic significance still remains controversial.We studied the presence of erythroblast antibodies in mitogen-stimulated bone marrow (BM) cultures of 70 patients with early-stage MDS (refractory anemia and refractory anemia with ringed sideroblasts).Sixty-six percent of patients showed positive erythroblast antibodies, along with BM erythroid hyperplasia and a hemolytic picture in the peripheral blood. Supernatants from positive cultures induced an increase of overall cellularity, the appearance of erythroblastic clustering, and dyserythropoietic signs in normal BM. We identified CD45(dim) Gly-A(dim) CD71(bright) cells (red blood cell precursors at different maturation stage) as the target of the antibodies. Erythropoietin (EPO) levels were reduced and EPO receptors (EPO-R) increased in BM culture supernatants from positive patients. However, flow cytometric analysis showed that neither EPO nor EPO-R was involved in an abnormal stimulation driven by these autoantibodies. Values of the proapoptotic protein Bax were increased in positive patients and Bcl-2 levels were decreased, although not significantly.MDS patients with anti-erythroblast autoimmunity showed increased BM apoptosis, suggesting that the autoimmune reaction may contribute to an unfavorable BM microenvironment for optimal erythropoiesis.

Published
2016

17. P.10.9: Outpatient Management of Patients with Glasgow-Blatchford Bleeding Score Low-Risk Upper-Gastrointestinal Hemorrhage: A Multicenter Validation Study in Italy

Author

F. De Nigris, A. Nucci, F. Cipolletta, R. Bennato, A. Bizzotto, F.R. De Filippo, C. Marmo, M. Manno, A. Repici, A. Paterlini, M. De Matthaeis, P. Di Giorgio, S. Segato, E. Di Giulio, R. Lamanda, G. Spinzi, G. Rotondano, M. Guardascione, G. Baldassarre, S. Bargiggia, A. Balzano, S. Mangiafico, L.G. Cavallaro, L. Ferraris, C. De Fanis, P. Gasparini, A. Merighi, R. Pumpo, A. Lauri, S. Metrangolo, Marco Soncini, Riccardo Marmo, L. Furio, A. Chirico, M. Parravicini, B. Germanà, D. Conte, R.M. Zagari, O. Triossi, F. Esposito, Annalisa Tortora, Alessandra Dell'Era, M. Franceschi, V. Boarino, A. Andriulli, R. De Franchis, A. Zambelli, F. Bazzoli, L. Cipolletta, C. Londoni, R. Conigliaro, L. Purita, E. Buscarini, P. Cesaro, G. Napolitano, Cristina Bucci, L. Orsini, P. Borgheresi, L.M. Montalbano, Maria Elena Riccioni, Guido Costamagna, G. D'Amico, G. Imperiali, A. Russo, M.A. Bianco, G. Bresci, A. Anderloni, and F. Parente

Subjects
medicine.medical_specialty, Validation study, Hepatology, business.industry, Gastroenterology, medicine, Upper gastrointestinal, Outpatient management, Intensive care medicine, business
Published
2017
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18. P.10.3: Mortality in Upper Gastrointestinal Bleeding in Italy: Data from National Survey

Author

A. Chirico, O. Triossi, Cristina Bucci, C. Londoni, S. Mangiafico, Guido Costamagna, M. De Matthaeis, C. De Fanis, F. Cipolletta, G. Baldassarre, A. Andriulli, A. Balzano, A. Repici, A. Paterlini, F. Parente, V. Boarino, R. Lamanda, A. Russo, P. Di Giorgio, S. Segato, M.A. Bianco, R. Bennato, G. Bresci, P. Cesaro, M. Manno, G. D'Amico, G. Spinzi, E. Di Giulio, G. Imperiali, L. Orsini, F. De Nigris, L. Cipolletta, R. Conigliaro, A. Nucci, A. Lauri, A. Bizzotto, F.R. De Filippo, C. Marmo, Maria Elena Riccioni, F. Esposito, L. Amitrano, C. Tomba, D. Conte, L.G. Cavallaro, B. Germanà, A. Anderloni, S. Metrangolo, A. Merighi, E. Buscarini, R. Pumpo, R.M. Zagari, Marco Soncini, Riccardo Marmo, R. De Franchis, A. Zambelli, F. Bazzoli, M. Parravicini, L. Ferraris, L. Purita, P. Borgheresi, L.M. Montalbano, S. Bargiggia, L. Furio, P. Gasparini, Annalisa Tortora, M. Franceschi, Alessandra Dell'Era, G. Napolitano, and G. Rotondano

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, General surgery, Gastroenterology, medicine, Upper gastrointestinal bleeding, medicine.disease, business
Published
2017
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19. P.10.1: Transfusion Strategy and Death Risk in Patients with Acute Non-Variceal Upper Gastro Intestinal Bleeding (NV-UGIB) in Italy: A Prospective Multicenter Observational Study

Author

A. Balzano, R. Bennato, M. Manno, S. Mangiafico, C. De Fanis, F. Esposito, F. De Nigris, R. De Franchis, A. Zambelli, F. Bazzoli, V. Boarino, Annalisa Tortora, A. Nucci, M. Franceschi, R. Lamanda, A. Bizzotto, F.R. De Filippo, S. Segato, C. Marmo, A. Andriulli, P. Cesaro, E. Buscarini, F. Zingone, A. Chirico, L. Amitrano, S. Mastrangelo, P. Borgheresi, L.M. Montalbano, L.G. Cavallaro, E. Di Giulio, O. Triossi, S. Bargiggia, A. Merighi, F. Parente, C. Londoni, M. De Matthaeis, G. D'Amico, R. Lauri, F. Cipolletta, P. Gasparini, G. Imperiali, Guido Costamagna, P. Di Giorgio, A. Repici, A. Paterlini, A. Anderloni, R.M. Zagari, Cristina Bucci, A. Russo, L. Ferraris, M.A. Bianco, R. Pumpo, G. Baldassarre, G. Bresci, D. Conte, L. Cipolletta, R. Conigliaro, B. Germanà, Marco Soncini, Riccardo Marmo, L. Orsini, Maria Elena Riccioni, Alessandra Dell'Era, G. Napolitano, L. Furio, M. Parravicini, L. Purita, and G. Spinzi

Subjects
medicine.medical_specialty, Hepatology, business.industry, Death risk, Emergency medicine, Gastroenterology, medicine, In patient, Observational study, Gastro intestinal bleeding, Intensive care medicine, business
Published
2017
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20. P.12.3: Accuracy of Endoscopic Resection for Non-Pedunculated Colonic Lesions 5–20 Mm with or without Narrow Band Imaging (NBI): A Multicentre, Prospective, Randomized Trial

Author

Alida Andrealli, Arnaldo Amato, Giancarlo Spinzi, Franco Radaelli, Enzo Masci, G. Mandelli, G. Imperiali, Silvia Paggi, Emanuele Rondonotti, Flaminia Cavallaro, Nicoletta Lenoci, and Natalia Terreni

Subjects
medicine.medical_specialty, Narrow-band imaging, Hepatology, Randomized controlled trial, law, business.industry, Gastroenterology, Medicine, Endoscopic resection, Radiology, business, law.invention
Published
2017
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21. Detection of red blood cell antibodies in mitogen-stimulated cultures from patients with hereditary spherocytosis

Author

Anna, Zaninoni, Cristina, Vercellati, Francesca G, Imperiali, Anna P, Marcello, Bruno, Fattizzo, Elisa, Fermo, Paola, Bianchi, Claudia, Grossi, Alessandra, Cattaneo, Agostino, Cortelezzi, Alberto, Zanella, and Wilma, Barcellini

Subjects
Adult, Aged, 80 and over, Male, Erythrocytes, Adolescent, Spherocytosis, Hereditary, Middle Aged, Coombs Test, Child, Preschool, Immunoglobulin G, Humans, Female, Mitogens, Child, Cellular Senescence, Aged, Autoantibodies
Abstract

Hereditary spherocytosis (HS) is a congenital hemolytic anemia caused by defects in red blood cell (RBC) membrane proteins leading to premature RBC clearance in the spleen. The presence of RBC autoantibodies has never been extensively investigated in HS.RBC antibody-bound immunoglobulin (Ig)G was investigated in 91 consecutive HS patients by mitogen-stimulated direct antiglobulin test (MS-DAT), a sensitive method able to magnify latent RBC antibody autoimmunity and related with hemolytic variables, previous splenectomy, and type of membrane defect.A total of 61% of HS cases had RBC antibodies by MS-DAT (29 Band 3, 17 spectrin deficiency, and nine no defined defect). The amount of RBC-bound IgG was greater in HS compared with controls (236 ± 192 ng/mL vs. 52 ± 29 ng/mL, p 0.0001), although lower than that observed in autoimmune hemolytic anemia (AIHA; 634 ± 371 ng/mL vs. 236 ± 192 ng/mL, p 0.0001). Western blot experiments showed that purified IgG fraction from MS-DAT-positive patients bind to α- and β-spectrin, Band 3, and Band 4.9. Positive cases displayed increased reticulocytosis and slightly reduced hemoglobin (Hb) values compared to negative ones. Patients displaying RBC-bound IgG of more than 250 ng/mL (the positive threshold of AIHA) showed increased number of spherocytes and mainly had spectrin deficiency. RBC-bound IgG and free Hb increased over time after storage at 4°C, a surrogate of ex vivo aging, more evidently in HS than controls, and particularly in Band 3 deficiency.RBC autoantibodies were detected by MS-DAT in more than a half of HS patients. Positive cases showed a more evident hemolytic pattern suggesting a pathogenic role of these autoantibodies in RBC opsonization and splenic removal.

Published
2014

22. P.15.3 INCREASED PERFORMANCE OF AN UPDATED ROCKALL SCORE IN ACUTE NON VARICEAL UPPER GASTRO INTESTINAL BLEEDING: A PROSPECTIVE MULTICENTRE ITALIAN STUDY

Author

E. Masci, S. De Stefano, S. Segato, A. Russo, D. Conte, L.G. Cavallaro, M. Martorano, M.A. Bianco, R.M. Zagari, L. Cipolletta, G. Bresci, R. Marin, G. Spinzi, A. Andreloni, Cristina Bucci, S. Metrangolo, G. Baldassarre, R. Lamanda, A. Lauri, L. Amitrano, G. D'Amico, L. Ferraris, A. Merighi, A. Chirico, C. De Fanis, R. De Franchis, O. Triossi, G. Imperiali, F. Cipolletta, G. Coccia, A. Repici, A. Paterlini, B. Germanà, S. Antoniazzi, E. Buscarini, Alessandra Dell'Era, Annalisa Tortora, M. Franceschi, L. Furio, G. Rotondano, S. Bargiggia, A. Maringhini, P. Gasparini, M. De Matthaeis, P. Di Giorgio, F. De Nigris, A. Nucci, F. Politi, A. Bizzotto, M. Parravicini, P. Borgheresi, L.M. Montalbano, C. Marmo, L. Purita, E. Di Giulio, R. Pumpo, R. Bennato, A. Balzano, Marco Soncini, Riccardo Marmo, V. Boarino, P. Cesaro, F. Parente, and Maria Elena Riccioni

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Gastro intestinal bleeding, business, Rockall score
Published
2016
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23. Bone marrow mitogen-stimulated direct antiglobulin test in a case of erythroblastic synartesis

Author

Anna, Zaninoni, Francesca G, Imperiali, Mauro, Pomati, Mariangela, Colombi, Carla, Boschetti, and Wilma, Barcellini

Subjects
Adult, Killer Cells, Natural, Male, Anemia, Hemolytic, Erythroblasts, T-Lymphocytes, Humans, Anemia, Bone Marrow Cells, Erythropoiesis, Cytotoxicity Tests, Immunologic, Antibodies, Anti-Idiotypic
Abstract

In this article we report a case of erythroblastic synartesis, a rare disease characterized by ineffective erythropoiesis, clusters of erythroblasts due to membrane invaginations, in which an autoimmune pathogenesis is hypothesized. We investigated the presence of anti-erythroblast autoimmunity in bone marrow cultures using a mitogen-stimulated direct antiglobulin test, a method reported to be able to disclose a latent autoimmunity in various diseases. The test revealed the presence of erythroblast-bound IgG, supporting the hypothesis of the autoimmune pathogenesis of erythroblastic synartesis. Supernatants induced the same specific morphological features, i.e erythroblastic clustering and diserythropoietic signs (multiple nuclei, nuclear inclusions, and intercellular bridges) in normal progenitors.

Published
2010

24. Hereditary red cell membrane defects: diagnostic and clinical aspects

Author

Wilma, Barcellini, Paola, Bianchi, Elisa, Fermo, Francesca G, Imperiali, Anna P, Marcello, Cristina, Vercellati, Anna, Zaninoni, and Alberto, Zanella

Subjects
Erythrocyte Membrane, Elliptocytosis, Hereditary, Erythrocytes, Abnormal, Humans, Reviews, Spherocytosis, Hereditary
Published
2010

25. Segmental colitis associated with diverticula: a prospective study

Author

A. Ferrara, F. Rocca, Giorgio Minoli, Gianmichele Meucci, G. Imperiali, Carlo Maria Girelli, Renato Fasoli, Costanza Alvisi, and Simone Saibeni

Subjects
medicine.medical_specialty, Abdominal pain, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, Colonoscopy, Rectum, medicine.disease, Inflammatory bowel disease, digestive system diseases, Hematochezia, Surgery, Diarrhea, medicine.anatomical_structure, Internal medicine, medicine, Colitis, medicine.symptom, Prospective cohort study, business
Abstract

OBJECTIVE: Little is known about the clinical features and natural history of segmental colitis associated with diverticula. Our aim was to evaluate the incidence of segmental colitis associated with diverticula in patients undergoing colonoscopy, its clinical picture, and its outcome. METHODS: This was a multicenter, prospective study. Patients with inflammatory bowel disease (IBD)-like lesions limited to colonic segments with diverticula were enrolled. Patients were treated with oral and topical 5-aminosalicylic (5-ASA) until remission was achieved; clinical and endoscopic follow-up was planned at 6 wk and 12 months. RESULTS: A total of 5457 consecutive colonoscopies were recorded at five participating institutions; 20 patients (0.36%) met the endoscopic criteria for segmental colitis associated with diverticula. All had lesions in the left colon, and one also had lesions in the right colon. In six cases, a specific diagnosis was made thereafter. The remaining 14 patients (0.25% of colonoscopies; eight men; age range, 49-80 yr) were in clinical and endoscopic remission at the first follow-up visit. At onset, 13/14 had hematochezia, seven had diarrhea, and five had abdominal pain; only one had weight loss. No subject had fever. In all but one case, blood chemistries were normal. Five patients had had similar symptoms previously. Thirteen of 14 patients were in clinical and endoscopic remission at 12 months. CONCLUSIONS: This endoscopic picture is not an exceptional finding. Hematochezia was the main clinical feature, and no relation with gender, age, or smoking habit was found. Blood chemistries were generally normal and the rectum was spared. The histological features were not diagnostic and most patients did not complain of any abdominal symptoms 12 months after enrollment.

Published
2000
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26. P.15.9 TRANSFUSION STRATEGY AND DEATH RISK IN PATIENTS WITH ACUTE NON VARICEAL UPPER GASTRO INTESTINAL BLEEDING (NV-UGIB) IN ITALY: A PROSPECTIVE MULTICENTER OBSERVATIONAL STUDY

Author

R. Marmo, M. Soncini, L. Cipolletta, F. Parente, A. Paterlini, R. Bennato, F. Cipolletta, L. Orsini, S. Bargiggia, P. Cesaro, A. Bizzotto, A. Dell'Era, B. Germanà, L.G. Cavallaro, M.E. Riccioni, C. Marmo, A. Tortora, S. Segato, M. Parravicini, L. Purita, A. Chirico, G. Spinzi, G. Imperiali, A. Maringhi, V. Boarino, G. Bresci, S. Metrangolo, C. Bucci, G. Baldassarre, M. Franceschi, A. Nucci, F. De Nigris, E. Masci, R. Marin, S. Antoniazzi, L. Ferraris, A. Repici, A. Andreloni, M.A. Bianco, G. Rotondano, M. De Matthaeis, A. Lauri, C. De Fanis, P. Borgheresi, S. De Stefano, R. Lamanda, L. Furio, A. Russo, P. Di Giorgio, F. Politi, R. Pumpo, O. Triossi, G. Coccia, L.M. Montalbano, R.M. Zagari, A. Balzano, E. Buscarini, D. Conte, G. D'Amico, E. Di Giulio, P. Gasparini, and R. De Franchis

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Death risk, Gastroenterology, medicine, Observational study, In patient, Gastro intestinal bleeding, business
Published
2016
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27. OC.01.9 OLGA-BASED STAGING AND DYSPLASIA RELEVANCE IN 50–70 YEARS OLD PATIENTS IN A PRIMARY OPEN ACCESS ENDOSCOPY: PRELIMINARY RESULTS

Author

Franco Radaelli, Nicoletta Lenoci, G. Mandelli, G. Imperiali, Silvia Paggi, Giancarlo Spinzi, Natalia Terreni, Emanuele Rondonotti, Arnaldo Amato, and Alida Andrealli

Subjects
Old patients, medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, General surgery, Gastroenterology, medicine.disease, Endoscopy, Surgery, Dysplasia, medicine, Relevance (information retrieval), business
Published
2016
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28. Segmental colitis associated with diverticula: a prospective study. Gruppo di Studio per le Malattie Infiammatorie Intestinali (GSMII)

Author

G, Imperiali, G, Meucci, C, Alvisi, R, Fasoli, A, Ferrara, C M, Girelli, F, Rocca, S, Saibeni, and G, Minoli

Subjects
Aged, 80 and over, Male, Anti-Inflammatory Agents, Non-Steroidal, Humans, Female, Colonoscopy, Prospective Studies, Middle Aged, Colitis, Inflammatory Bowel Diseases, Mesalamine, Aged, Diverticulitis, Colonic
Abstract

Little is known about the clinical features and natural history of segmental colitis associated with diverticula. Our aim was to evaluate the incidence of segmental colitis associated with diverticula in patients undergoing colonoscopy, its clinical picture, and its outcome.This was a multicenter, prospective study. Patients with inflammatory bowel disease (IBD)-like lesions limited to colonic segments with diverticula were enrolled. Patients were treated with oral and topical 5-aminosalicylic (5-ASA) until remission was achieved; clinical and endoscopic follow-up was planned at 6 wk and 12 months.A total of 5457 consecutive colonoscopies were recorded at five participating institutions; 20 patients (0.36%) met the endoscopic criteria for segmental colitis associated with diverticula. All had lesions in the left colon, and one also had lesions in the right colon. In six cases, a specific diagnosis was made thereafter. The remaining 14 patients (0.25% of colonoscopies; eight men; age range, 49-80 yr) were in clinical and endoscopic remission at the first follow-up visit. At onset, 13/14 had hematochezia, seven had diarrhea, and five had abdominal pain; only one had weight loss. No subject had fever. In all but one case, blood chemistries were normal. Five patients had had similar symptoms previously. Thirteen of 14 patients were in clinical and endoscopic remission at 12 months.This endoscopic picture is not an exceptional finding. Hematochezia was the main clinical feature, and no relation with gender, age, or smoking habit was found. Blood chemistries were generally normal and the rectum was spared. The histological features were not diagnostic and most patients did not complain of any abdominal symptoms 12 months after enrollment.

Published
2000

29. PREDICTION OF MORTALITY FROM UPPER GASTRO-INTESTINAL BLEEDING: COMPARISON OF ROCKALL SCORE VS THE ITALIAN PNED SCORE

Author

Tino Casetti, S. Boschetto, R. Di Mitri, Lucio Capurso, Fabio Fornari, I. Sorrentini, Massimo Proietti, R. Macchiarelli, G. Frosini, Enzo Grossi, U. Germani, D. Di Muzio, Livio Cipolletta, M. Del Piano, G. Imperiali, Barbara Ferri, Paolo Michetti, Tommaso Ceglia, Angelo Dezi, L. Pietrini, M. Di Cicco, G. Gatto, Riccardo Marmo, I. Stroppa, S. De Stefano, Giovanni Aragona, Mario Salvagnini, Maria A. Bianco, Maurizio Koch, N. Della Casa, Gianluca Rotondano, M. Pagliarulo, Ivano Lorenzini, Alessandro Gigliozzi, A. Buzzi, Renzo Cestari, V. Peri, Paola Romagnoli, W. Piubello, Sirio Bagnoli, and G. Trallori

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Gastro intestinal bleeding, Rockall score, business
Published
2009
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30. PREDICTIVE FACTORS OF MORTALITY IN UPPER NONVARICEAL GI BLEEDING: VALIDATION OF A NEW PROGNOSTIC MODEL FROM A MULTICENTER ITALIAN STUDY

Author

I. Zagni, G. Frosini, Maria A. Bianco, N. Della Casa, Gianluca Rotondano, G. Trallori, M. Milla, Riccardo Marmo, Paolo Michetti, G. Imperiali, Mario Salvagnini, F. Russo, Lucio Capurso, Fabio Fornari, S. DeStefano, Livio Cipolletta, Roberto Lamanda, S. Carmagnola, I. Sorrentini, Ivano Lorenzini, Maurizio Koch, M. DelPiano, G. Gatto, S. DiMitri, Alessandro Gigliozzi, F. Giangregorio, M. Marino, S. Boschetto, I. Stroppa, D. DiMuzio, U. Germani, A. Allegretti, G. Longobardi, Tino Casetti, Enzo Grossi, Massimo Proietti, Angelo Dezi, M. Di Cicco, Omero Triossi, W. Piubello, and Renzo Cestari

Subjects
medicine.medical_specialty, Hepatology, GI bleeding, business.industry, Gastroenterology, Prognostic model, medicine, Intensive care medicine, business
Published
2009
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31. PA.218 DIFFERENT ENDOTHERAPY PROCEDURES HAD DIFFERENT IMPACT ON REBLEEDING AND DEATH RATE FROM ULCER BLEEDING WITH HIGH RISK STIGMATA: A POST HOC ANALYSIS FROM A RANDOMIZED CLINICAL TRIAL

Author

A. Caroli, Fabio Fornari, Giovanni Aragona, P. Tonti, F. Forte, A. Garripoli, S. Peyre, F. Giusi, R. Focareta, Angelo Andriulli, Riccardo Marmo, Fabio Monica, P. Leo, Antonio Merla, Silvano Loperfido, G. Forte, G. Imperiali, A. Spadaccini, and N. Caruso

Subjects
medicine.medical_specialty, Hepatology, Ulcer bleeding, business.industry, Mortality rate, Gastroenterology, Surgery, law.invention, Randomized controlled trial, law, Post-hoc analysis, medicine, Stigmata, business
Published
2008
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32. Colonic neoplasm in asymptomatic patients with family history of colon cancer: results of a colonoscopic prospective and controlled study. Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy

Author

G, Imperiali and G, Minoli

Subjects
Adenoma, Adult, Clinical Trials as Topic, Incidence, Carcinoma, Pilot Projects, Colonoscopy, Middle Aged, Pedigree, Italy, Risk Factors, Colonic Neoplasms, Humans, Prospective Studies, Registries, Colorectal Neoplasms, Aged
Published
1999

33. Emergency endoscopy in upper gastrointestinal bleeding at a second level unit: clinical results and quality assurance (QA), three year experience

Author

G, Imperiali and G, Minoli

Subjects
Clinical Trials as Topic, Quality Assurance, Health Care, Hemostasis, Endoscopic, Guidelines as Topic, Esophageal and Gastric Varices, Endoscopy, Gastrointestinal, Peptic Ulcer Hemorrhage, Treatment Outcome, Italy, Secondary Prevention, Humans, Stomach Ulcer, Emergencies, Gastrointestinal Hemorrhage
Published
1998

34. P475 Granulocyte and Monocyte Apheresis (GMA) – Adacolumn® in mild to moderate ulcerative colitis patients with steroid resistance or dependence and azathioprine intolerance or resistance: a prospective multicenter study (preliminary data)

Author

G. Imperiali, Maria M. Terpin, Arnaldo Amato, G. Meucci, and Aurora Bortoli

Subjects
medicine.medical_specialty, business.industry, Monocyte, Gastroenterology, Azathioprine, General Medicine, Granulocyte, Steroid resistance, medicine.disease, Ulcerative colitis, Apheresis, medicine.anatomical_structure, Multicenter study, Internal medicine, Immunology, medicine, business, medicine.drug
Abstract

P475 Granulocyte and Monocyte Apheresis (GMA) Adacolumn® in mild to moderate ulcerative colitis patients with steroid resistance or dependence and azathioprine intolerance or resistance: a prospective multicenter study (preliminary data) G. Imperiali1 *, M.M. Terpin2, A. Amato1, A. Bortoli3, G. Meucci4. 1Valduce Hospital, Gastroenterology, Como, Italy, 2Legnano Hospital, Gastroenterology, Legnano, Italy, 3Rho Hospital, Gastroenterology, Rho, Italy, 4S. Giuseppe Hospital, Gastroenterology, Milano, Italy

Published
2014
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35. P.07.3 PILLCAM COLON CAPSULE 2® IN THE SETTING OF COLORECTAL CANCER SCREENING PROGRAM: PRELIMINARY RESULTS OF THE COMPARISON WITH A NEW INTEGRATED REFERENCE STANDARD

Author

Franco Radaelli, G. Mandelli, Giancarlo Spinzi, Silvia Paggi, Nicoletta Lenoci, Natalia Terreni, A. Martegani, Vittorio Terruzzi, G. Imperiali, Emanuele Rondonotti, C. Borghi, and Arnaldo Amato

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Colorectal cancer screening, Internal medicine, Gastroenterology, medicine, Capsule, business, Reference standards
Published
2013
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36. Biphasic annual periodicity in relapses of inflammatory bowel diseases. Gruppo di Studio per le Malattie Infiammatorie Intestinale

Author

G, Minoli, G, Imperiali, E, Colombo, R, De Franchis, G, Mortara, A, Prada, and F, Rocca

Subjects
Male, Periodicity, Crohn Disease, Recurrence, Humans, Colitis, Ulcerative, Female, Prospective Studies
Abstract

We evaluate the periodicity in relapses of ulcerative colitis and Crohn's disease in this multicenter prospective study. In 275 relapses among 184 patients with inflammatory bowel disease, a statistically significant biphasic annual periodicity, with peaks in the spring and autumn, was documented only for ulcerative colitis relapses (p = 0.006). This finding may be important in understanding relapse risk factors and in terms of prevention.

Published
1995

38. P.13.20 RESECT AND DISCARD STRATEGY IN CLINICAL PRACTICE: A PROSPECTIVE STUDY

Author

Giancarlo Spinzi, Vittorio Terruzzi, Silvia Paggi, Emanuele Rondonotti, Nicoletta Lenoci, Natalia Terreni, Franco Radaelli, G. Mandelli, Arnaldo Amato, and G. Imperiali

Subjects
Clinical Practice, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Medicine, Prospective cohort study, business, Intensive care medicine
Published
2012
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39. THE IMPACT OF NARROW BAND IMAGING IN SCREENING COLONOSCOPY: A RANDOMISED CONTROLLED TRIAL

Author

G. Meucci, G. Imperiali, Natalia Terreni, Silvia Paggi, Vittorio Terruzzi, Giancarlo Spinzi, Franco Radaelli, G. Mandelli, Arnaldo Amato, Anna Toldi, and Nicoletta Lenoci

Subjects
medicine.medical_specialty, Narrow-band imaging, Hepatology, Randomized controlled trial, law, business.industry, Gastroenterology, medicine, Radiology, Screening colonoscopy, business, law.invention
Published
2009
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40. SPLIT DOSES OF POLYETHYLENE GLYCOL (PEG) AND SENNA VERSUS HIGH-DOSE SENNA AS BOWEL PREPARATION FOR ELECTIVE COLONOSCOPY: A RANDOMIZED, INVESTIGATOR-BLINDED TRIAL

Author

Giancarlo Spinzi, Arnaldo Amato, Nicoletta Lenoci, G. Meucci, G. Imperiali, Silvia Paggi, Anna Toldi, Franco Radaelli, Vittorio Terruzzi, Natalia Terreni, and G. Mandelli

Subjects
medicine.medical_specialty, Hepatology, medicine.diagnostic_test, biology, business.industry, Senna, Gastroenterology, Colonoscopy, Polyethylene glycol, biology.organism_classification, Surgery, chemistry.chemical_compound, chemistry, PEG ratio, Bowel preparation, Medicine, business
Published
2009
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41. Factor Associated with Mortality from Non Variceal Upper Gastrointestinal Bleeding (UGIB) in Italy: A Nationwide Prospective Study

Author

S. Boschetto, Lucio Capurso, U. Germani, G. Gatto, A. Pastorelli, Mariano Amuso, Sergio Brunati, A. Buzzi, D. Della Casa, Riccardo Marmo, Lisa Girardi, F. Barberani, Ivano Lorenzini, Renato Fasoli, Paola Romagnoli, G. Di Matteo, Livio Cipolletta, Giorgio Minoli, E. Sanz Torre, P. Giorgio, G. Imperiali, Maria A. Bianco, Angelo Dezi, Maurizio Koch, and Gianluca Rotondano

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Gastroenterology, Medicine, Radiology, Nuclear Medicine and imaging, Upper gastrointestinal bleeding, business, Prospective cohort study, medicine.disease
Published
2007
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42. 19 P Single bolus of midazolam versus midazolam plus meperidine for colonoscopy. A prospective, randomized, double blind trial

Author

Gianmichele Meucci, E. Strocchi, Franco Radaelli, G. Mandelli, Giancarlo Spinzi, Nicoletta Lenoci, Anna Toldi, G. Imperiali, Natalia Terreni, Vittorio Terruzzi, and Giorgio Minoli

Subjects
Double blind, Hepatology, Single bolus, medicine.diagnostic_test, business.industry, Anesthesia, Gastroenterology, Medicine, Colonoscopy, Midazolam, business, medicine.drug
Published
2002
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43. Inflammatory bowel disease and pregnancy: A prospective case-control study

Author

R. Gullotta, M. Tatarella, Aurora Bortoli, M. Da Perna, G. Imperiali, R. De Franchis, R. Fasoli, L. Ferraris, Luigi Beretta, Alberto Prada, C. Vecchio, and C. Gerosa

Subjects
medicine.medical_specialty, Pregnancy, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Case-control study, medicine.disease, business, Inflammatory bowel disease
Published
2001
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44. The perception of quality of life in inflammatory bowel disease (IBD) mainly depends on disease activity

Author

Enrico Colombo, Pavia, M. Tatarella, Varese, G. Imperiali, Garbagnate, Costanza Alvisi, R. De Franchis, F. Rondonotti, Ada Corbellini, L. Ferraris, Rho, Milano, Melegnano, R. Rivolta, Simone Saibeni, Alberto Prada, and Monza

Subjects
medicine.medical_specialty, Hepatology, business.industry, media_common.quotation_subject, Gastroenterology, medicine.disease, Inflammatory bowel disease, Disease activity, Quality of life (healthcare), Internal medicine, Perception, medicine, business, media_common
Published
2000
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45. Effectiveness of a continuous quality improvement program on colonoscopy practice.

Author

G. Imperiali

Subjects
*COLONOSCOPY, *COLON examination, *ENDOSCOPY
Abstract

BACKGROUND AND STUDY AIM: Continuous quality improvement (CQI) is recommended by professional societies as part of every colonoscopy program, but little is known with regard to its effectiveness for colonoscopy outcomes. We prospectively assessed whether the implementation of a CQI program in routine clinical practice influences the quality performance of colonoscopy. METHODS: In an open-access endoscopy unit at a secondary care center in Northern Italy, 6-monthly audit cycles were carried out over a 4-year period, to identify reasons for poor colonoscopy outcomes and institute appropriate changes to improve performance. The colonoscopy completion rate and the polyp detection rate as detected by endoscopists were considered to be key measures for improvement. RESULTS: The initial crude colonoscopy completion rate was 84.6 %, with a range for individual endoscopists 80.4 % - 94 %. Four endoscopists had a completion rate lower than 90 %. The overall polyp detection rate was 34 %, with a wide variation among endoscopists (range 14 % - 42 %). Poor patient tolerance and differences in colonoscopist expertise were the main determinants of lack of completion and variation in polyp detection rate. Changes to sedation practice, greater access to endoscopy sessions for the endoscopists with the lowest performance rates, and other organizational arrangements, were implemented to improve quality performance. The crude completion rates improved consistently, up to 93.1 %, over the study period. This trend was confirmed even when adjusted completion rates were calculated. All endoscopists reached a crude completion rate of 90 % or more and a polyp detection rate of over 20 %. The introduction of CQI did not significantly change the overall incidence of procedure-related complications. CONCLUSIONS: The effectiveness of colonoscopy can be improved by implementing a CQI program in routine colonoscopy practice. [ABSTRACT FROM AUTHOR]

Published
2007
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46. EEG alpha reactivity and extraversion-introversion

Author

M. G. Imperiali, P. San Martini, R. Venturini, and V. De Pascalis

Subjects
medicine.medical_specialty, Extraversion and introversion, Alpha rhythm, medicine, Stimulation, Audiology, Stimulus (physiology), Spontaneous eeg, Psychology, General Psychology, Eysenck Personality Questionnaire, Eeg alpha, Developmental psychology
Abstract

Spectral characteristics of spontaneous EEG and characteristics of the alpha attenuation response (AAR) induced by acoustic stimulation, were analyzed for two groups of subjects selected on the basis of their scores on the extraversion-introversion scale of the Eysenck Personality Questionnaire. While no significant differences were found in basic alpha rhythm, significant differences were manifested in the AAR characteristics. Extraverted subjects habituated to the auditory stimulus while introverts did not. Introverts were generally more responsive to stimulation. The results are discussed in relation to the arousability model proposed by Eysenck and Gray, verifying the relationships with typological dimensions of Superior Nervous Activity, elaborated by the Soviet school.

Published
1981
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47. Personality, hypnotic susceptibility and EEG responses: Preliminary study

Author

M. G. Imperiali and V. De Pascalis

Subjects
Adult, Male, Hypnosis, medicine.medical_specialty, Adolescent, medicine.drug_class, media_common.quotation_subject, 050109 social psychology, Experimental and Cognitive Psychology, Electroencephalography, Audiology, 050105 experimental psychology, Hypnotic, medicine, Humans, Personality, 0501 psychology and cognitive sciences, Theta Rhythm, Dominance, Cerebral, media_common, medicine.diagnostic_test, 05 social sciences, Suggestibility, Neuroticism, Sensory Systems, Eysenck Personality Questionnaire, Alpha Rhythm, Female, Hypnotic susceptibility, Arousal, Beta Rhythm, Psychology, Social psychology
Abstract

22 men and women, students in psychology, were given the Eysenck Personality Questionnaire, also percent theta, alpha and beta EEG spectral powers were evaluated during an hypnotic induction induced according to Barber's method. The EEG performance was compared with two baseline eyes-open, eyes-closed conditions and with a neutral control situation of listening to a weather report. No relation was found between Extraversion-Introversion scores and scores on the Barber Suggestibility Scale. The difference in EEG powers was nonsignificant for groups high and low in suggestibility, while a significant interaction was found for eyes open or closed × suggestibility groups when extreme scores of Extraversion-Introversion and Neuroticism were considered according to Eysenck's (1966) method. The right theta power of the stable extraverts and neurotic introverts, high in susceptibility in eyes-open condition was higher than the neurotic extraverts, and stable introverts who were low in susceptibility to hypnosis. The right theta power of the neurotic extraverts and stable introverts who were low in susceptibility to hypnosis showed a tendency to increase in eyes-closed conditions, while an opposite observation was made for the stable extraverts and neurotic introverts, subjects who were high in susceptibility. It is interesting to notice, according to Galbraith, et al. (1970) that it was the eyes-open condition which yielded the best EEG predictor of hypnotic susceptibility.

Published
1984

48. [Pulmonary transplantation. Experimental study]

Author

L, Maggio, G, Daddi, R, Avallone, G, Cornia, A, Fantini, G, Giacalone, G, Imperiali, M, Mauro, G, Ruffo, and V, Tabocchini

Subjects
Dogs, Transplantation Immunology, Bronchoscopy, Animals, Transplantation, Homologous, Transplantation, Autologous, Immunosuppressive Agents, Lung Transplantation
Published
1968

50. Paracetamol Use and COVID-19 Clinical Outcomes: A Meta-Analysis.

Author

Bianconi A, Zauli E, Biagiotti C, Calò GL, Cioni G, Imperiali G, Orazi V, Acuti Martellucci C, Rosso A, and Fiore M

Abstract

Background: During the COVID-19 pandemic, paracetamol was widely recommended in different clinical settings, and sometimes advised over non-steroidal anti-inflammatory drugs (NSAIDs). These recommendations sparked a strong debate, with reports suggesting either potential benefits or harms for the individuals infected with SARS-CoV-2. As no systematic review is available, we performed a meta-analysis to estimate the impact of paracetamol on COVID-19 clinical outcomes compared to a placebo, no use, or NSAIDs., Methods: We searched PubMed, Scopus, Web of Science, and ClinicalTrials.gov for randomized trials or observational studies evaluating any COVID-19 clinical outcome. Data were combined using a generic inverse-variance approach. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach was used to determine the certainty of evidence for each outcome., Results: One randomized trial and five observational studies, enrolling over 34,000 patients, were included. Overall, as compared to the patients using NSAIDs or receiving no treatment, the individuals who received paracetamol showed no significant differences in the risk of death (summary relative risks 0.93 and 0.91, respectively: both p > 0.05), need to transfer to the intensive care unit, need for respiratory support, or cardiovascular or renal complications. All studies showed a high risk of bias, with a low overall quality of evidence., Conclusions: This meta-analysis found no evidence of harmful or beneficial effects of paracetamol on main COVID-19-related outcomes. Also, the current literature does not provide sufficient data to support a preferential choice between paracetamol and NSAIDs for COVID-19 symptoms management. Further research is needed to confirm the present findings and provide critical insights on the policies to adopt in the case of future pandemics.

Published
2024
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