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1. Impact of patient support programmes among patients with severe asthma treated with biological therapies: a systematic literature review and indirect treatment comparison

Author

Azeem Majeed, Liam G Heaney, Zhiyi Lan, Tamsin Morris, Olivia Fulton, Adrian P J Rabe, Wei J Loke, Danuta Kielar, Vivian H Shih, Lynda Olinger, Mihaela G Musat, and Sharada Harricharan

Subjects
Medicine, Diseases of the respiratory system, RC705-779
Abstract

Introduction Effective treatment of severe asthma requires patient adherence to inhaled and biological medications. Previous work has shown that patient support programmes (PSP) can improve adherence in patients with chronic diseases, but the impact of PSPs in patients with severe asthma treated with biologics has not been thoroughly investigated.Methods We conducted a systematic literature review to understand the impact of PSPs on treatment adherence, asthma control and health-related quality of life (HRQoL) in patients with severe asthma. Embase, MEDLINE and EconLit databases were searched for studies published from 2003 (the year of the first biological approval for severe asthma) to June 2023 that described PSP participation among patients with severe asthma on biological treatment. Direct pooling of outcomes was not possible due to the heterogeneity across studies, so an indirect treatment comparison (ITC) was performed to determine the effect of PSP participation on treatment discontinuation. The ITC used patient-level data from patients treated with benralizumab either enrolled in a PSP (VOICE study, Connect 360 PSP) or not enrolled in a PSP (Benralizumab Patient Access Programme study) in the UK.Findings 25 records of 21 studies were selected. Six studies investigated the impact of PSPs on treatment adherence, asthma control or HRQoL. All six studies reported positive outcomes for patients enrolled in PSPs; the benefits of each PSP were closely linked to the services provided. The ITC showed that patients in the Connect 360 PSP group were less likely to discontinue treatment compared with the non-PSP group (OR 0.26, 95% CI 0.11 to 0.57, p

Published
2024
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2. Validation of GEANT4 Monte Carlo Models with a Highly Granular Scintillator-Steel Hadron Calorimeter

Author

C Adloff, J Blaha, J -J Blaising, C Drancourt, A Espargilière, R Gaglione, N Geffroy, Y Karyotakis, J Prast, G Vouters, K Francis, J Repond, J Schlereth, J Smith, L Xia, E Baldolemar, J Li, S T Park, M Sosebee, A P White, J Yu, T Buanes, G Eigen, Y Mikami, N K Watson, G Mavromanolakis, M A Thomson, D R Ward, W Yan, D Benchekroun, A Hoummada, Y Khoulaki, J Apostolakis, A Dotti, G Folger, V Ivantchenko, V Uzhinskiy, M Benyamna, C Cârloganu, F Fehr, P Gay, S Manen, L Royer, G C Blazey, A Dyshkant, J G R Lima, V Zutshi, J -Y Hostachy, L Morin, U Cornett, D David, G Falley, K Gadow, P Göttlicher, C Günter, B Hermberg, S Karstensen, F Krivan, A -I Lucaci-Timoce, S Lu, B Lutz, S Morozov, V Morgunov, M Reinecke, F Sefkow, P Smirnov, M Terwort, A Vargas-Trevino, N Feege, E Garutti, I Marchesini, M Ramilli, P Eckert, T Harion, A Kaplan, H -Ch Schultz-Coulon, W Shen, R Stamen, B Bilki, E Norbeck, Y Onel, G W Wilson, K Kawagoe, P D Dauncey, A -M Magnan, V Bartsch, M Wing, F Salvatore, E Calvo Alamillo, M -C Fouz, J Puerta-Pelayo, B Bobchenko, M Chadeeva, M Danilov, A Epifantsev, O Markin, R Mizuk, E Novikov, V Popov, V Rusinov, E Tarkovsky, N Kirikova, V Kozlov, Y Soloviev, P Buzhan, A Ilyin, V Kantserov, V Kaplin, A Karakash, E Popova, V Tikhomirov, C Kiesling, K Seidel, F Simon, C Soldner, M Szalay, M Tesar, L Weuste, M S Amjad, J Bonis, S Callier, S Conforti di Lorenzo, P Cornebise, Ph Doublet, F Dulucq, J Fleury, T Frisson, N van der Kolk, H Li, G Martin-Chassard, F Richard, Ch de la Taille, R Pöschl, L Raux, J Rouëné, N Seguin-Moreau, M Anduze, V Boudry, J-C Brient, D Jeans, P Mora de Freitas, G Musat, M Reinhard, M Ruan, H Videau, B Bulanek, J Zacek, J Cvach, P Gallus, M Havranek, M Janata, J Kvasnicka, D Lednicky, M Marcisovsky, I Polak, J Popule, L Tomasek, M Tomasek, P Ruzicka, P Sicho, J Smolik, V Vrba, J Zalesak, B Belhorma, H Ghazlane, T Takeshita, S Uozumi, M Götze, O Hartbrich, J Sauer, S Weber, C Zeitnitz, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), CALICE, Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Highly Granular Calorimetry [9.5], Hadron, Monte Carlo method, FOS: Physical sciences, Scintillator, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Silicon photomultiplier, Pion, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], ddc:610, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, 010306 general physics, physics.ins-det, Instrumentation, Mathematical Physics, Advanced infrastructures for detector R&D [9], Physics, Range (particle radiation), hep-ex, 010308 nuclear & particles physics, Instrumentation and Detectors (physics.ins-det), Computational physics, Calorimeter, High Energy Physics::Experiment, Granularity, Particle Physics - Experiment
Abstract

Calorimeters with a high granularity are a fundamental requirement of the Particle Flow paradigm. This paper focuses on the prototype of a hadron calorimeter with analog readout, consisting of thirty-eight scintillator layers alternating with steel absorber planes. The scintillator plates are finely segmented into tiles individually read out via Silicon Photomultipliers. The presented results are based on data collected with pion beams in the energy range from 8GeV to 100GeV. The fine segmentation of the sensitive layers and the high sampling frequency allow for an excellent reconstruction of the spatial development of hadronic showers. A comparison between data and Monte Carlo simulations is presented, concerning both the longitudinal and lateral development of hadronic showers and the global response of the calorimeter. The performance of several GEANT4 physics lists with respect to these observables is evaluated. Calorimeters with a high granularity are a fundamentalrequirement of the Particle Flow paradigm. This paper focuses on theprototype of a hadron calorimeter with analog readout, consisting ofthirty-eight scintillator layers alternating with steel absorberplanes. The scintillator plates are finely segmented into tilesindividually read out via Silicon Photomultipliers. The presentedresults are based on data collected with pion beams in the energyrange from 8 GeV to 100 GeV. The fine segmentation of thesensitive layers and the high sampling frequency allow for anexcellent reconstruction of the spatial development of hadronicshowers. A comparison between data and Monte Carlo simulations ispresented, concerning both the longitudinal and lateral developmentof hadronic showers and the global response of the calorimeter. Theperformance of several GEANT4 physics lists with respect tothese observables is evaluated. Calorimeters with a high granularity are a fundamental requirement of the Particle Flow paradigm. This paper focuses on the prototype of a hadron calorimeter with analog readout, consisting of thirty-eight scintillator layers alternating with steel absorber planes. The scintillator plates are finely segmented into tiles individually read out via Silicon Photomultipliers. The presented results are based on data collected with pion beams in the energy range from 8GeV to 100GeV. The fine segmentation of the sensitive layers and the high sampling frequency allow for an excellent reconstruction of the spatial development of hadronic showers. A comparison between data and Monte Carlo simulations is presented, concerning both the longitudinal and lateral development of hadronic showers and the global response of the calorimeter. The performance of several GEANT4 physics lists with respect to these observables is evaluated.

Published
2013
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3. Construction and performance of a silicon photomultiplier/extruded scintillator tail-catcher and muon-tracker

Author

C Adloff, J Blaha, J -J Blaising, C Drancourt, A Espargilière, R Gaglione, N Geffroy, Y Karyotakis, J Prast, G Vouters, B Bilki, K Francis, J Repond, J Smith, L Xia, E Baldolemar, J Li, S T Park, M Sosebee, A P White, J Yu, T Buanes, G Eigen, Y Mikami, N K Watson, G Mavromanolakis, M A Thomson, D R Ward, W Yan, D Benchekroun, A Hoummada, Y Khoulaki, M Benyamna, C Cârloganu, F Fehr, P Gay, S Manen, L Royer, G C Blazey, S Boona, D Chakraborty, A Dyshkant, D Hedin, J G R Lima, J Powell, V Rykalin, N Scurti, M Smith, N Tran, V Zutshi, J -Y Hostachy, L Morin, U Cornett, D David, J Dietrich, G Falley, K Gadow, P Göttlicher, C Günter, B Hermberg, S Karstensen, F Krivan, A -I Lucaci-Timoce, S Lu, B Lutz, I Marchesini, S Morozov, V Morgunov, M Reinecke, F Sefkow, P Smirnov, M Terwort, A Vargas-Trevino, N Feege, E Garutti, P Eckert, A Kaplan, H -Ch Schultz-Coulon, W Shen, R Stamen, A Tadday, E Norbeck, Y Onel, G W Wilson, K Kawagoe, S Uozumi, P D Dauncey, A -M Magnan, V Bartsch, M Wing, F Salvatore, E Calvo Alamillo, M -C Fouz, J Puerta-Pelayo, B Bobchenko, M Chadeeva, M Danilov, A Epifantsev, O Markin, R Mizuk, E Novikov, V Rusinov, E Tarkovsky, N Kirikova, V Kozlov, Y Soloviev, P Buzhan, B Dolgoshein, A Ilyin, V Kantserov, V Kaplin, A Karakash, E Popova, S Smirnov, A Frey, C Kiesling, K Seidel, F Simon, C Soldner, L Weuste, J Bonis, B Bouquet, S Callier, P Cornebise, Ph Doublet, F Dulucq, M Faucci Giannelli, J Fleury, H Li, G Martin-Chassard, F Richard, Ch de la Taille, R Pöschl, L Raux, N Seguin-Moreau, F Wicek, M Anduze, V Boudry, J-C Brient, D Jeans, P Mora de Freitas, G Musat, M Reinhard, M Ruan, H Videau, B Bulanek, J Zacek, J Cvach, P Gallus, M Havranek, M Janata, J Kvasnicka, D Lednicky, M Marcisovsky, I Polak, J Popule, L Tomasek, M Tomasek, P Ruzicka, P Sicho, J Smolik, V Vrba, J Zalesak, B Belhorma, H Ghazlane, T Takeshita, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), CALICE, Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Physics - Instrumentation and Detectors, International Linear Collider, Physics::Instrumentation and Detectors, FOS: Physical sciences, Scintillator, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Tracking (particle physics), 01 natural sciences, 7. Clean energy, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Silicon photomultiplier, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Fermilab, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment (nucl-ex), Detectors and Experimental Techniques, 010306 general physics, Nuclear Experiment, Instrumentation, Mathematical Physics, Physics, Large Hadron Collider, 010308 nuclear & particles physics, Detector, Instrumentation and Detectors (physics.ins-det), Calorimeter, Physics::Accelerator Physics, High Energy Physics::Experiment
Abstract

A prototype module for an International Linear Collider (ILC) detector was built, installed, and tested between 2006 and 2009 at CERN and Fermilab as part of the CALICE test beam program, in order to study the possibilities of extending energy sampling behind a hadronic calorimeter and to study the possibilities of providing muon tracking. The "tail catcher/muon tracker" (TCMT) is composed of 320 extruded scintillator strips (dimensions 1000 mm x 50 mm x 5 mm) packaged in 16 one-meter square planes interleaved between steel plates. The scintillator strips were read out with wavelength shifting fibers and silicon photomultipliers. The planes were arranged with alternating horizontal and vertical strip orientations. Data were collected for muons and pions in the energy range 6 GeV to 80 GeV. Utilizing data taken in 2006, this paper describes the design and construction of the TCMT, performance characteristics, and a beam-based evaluation of the ability of the TCMT to improve hadronic energy resolution in a prototype ILC detector. For a typical configuration of an ILC detector with a coil situated outside a calorimeter system with a thickness of 5.5 nuclear interaction lengths, a TCMT would improve relative energy resolution by 6-16 % for pions between 20 and 80 GeV., 23 pages, 18 figures, 4 tables, submitted to JINST

Published
2012
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4. Effects of high-energy particle showers on the embedded front-end electronics of an electromagnetic calorimeter for a future lepton collider

Author

U. Cornett, C. Adloff, M. A. Thomson, M. Reinecke, J. Fleury, S. Callier, D. David, Jose Repond, O. Wendt, N. Feege, E. Calvo Alamillo, Andrew White, Kiyotomo Kawagoe, D. Trojand, Y. Mikami, N. Wattimena, H. Li, Frank Simon, P. Cornebise, F. Fehr, B. Lutz, P. Eckert, D. R. Ward, M. C. Fouz, J-Y. Hostachy, Jiang Li, Ivan Marchesini, K. Francis, M. Terwort, P. D. Dauncey, L. Raux, Wei Shen, H. Ch Schultz-Coulon, E. Norbeck, Johannes Haller, S. Richter, A.S. Dyshkant, P. A. Smirnov, H. Ghazlane, Ph. Doublet, Vaclav Vrba, Jong-Sung Yu, J. Samson, V. Morgunov, E. Baldolemar, V. Boudry, K. Gadow, Erika Garutti, Daniel Jeans, Manqi Ruan, G. Falley, Anne-Marie Magnan, N. K. Watson, M. Faucci Giannelli, S. Lu, S. Karstensen, F. Krivan, P. Göttlicher, C. Günter, P. Mora de Freitas, M. Sosebee, F. Salvatore, F. Dulucq, G. C. Blazey, B. Belhorma, F. Wicek, Ch. de la Taille, S. V. Morozov, Yasar Onel, J. Bonis, Petr Sicho, Driss Benchekroun, Imad Baptiste Laktineh, L. Morin, N. T. Meyer, C. Kiesling, Y. Khoulaki, M. Reinhard, G. Musat, S. Manen, A. Tadday, Michal Marcisovsky, Lei Xia, A. I. Lucaci-Timoce, A. Vargas-Trevino, Abdeslam Hoummada, J. Zálešák, N. Seguin-Moreau, F. Sefkow, Francois Richard, R. Pöschl, S. Uozumi, Burak Bilki, A. Frey, H. Videau, G. Martin-Chassard, C. Cârloganu, Rainer Stamen, A. Kaplan, J. Puerta-Pelayo, B. Bouquet, L. Royer, J. Smith, M. Benyamna, Georgios Mavromanolakis, W. Yan, V. Zutshi, J. C. Brient, Riccardo Fabbri, S. T. Park, V. Bartsch, M. Anduze, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), CALICE, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear and High Energy Physics, Particle physics, High energy particle, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, FOS: Physical sciences, Integrated circuit, 01 natural sciences, Noise (electronics), law.invention, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Optics, Application-specific integrated circuit, law, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], ddc:530, Electronics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, 010306 general physics, Collider, Instrumentation, Physics, 010308 nuclear & particles physics, business.industry, Detector, Instrumentation and Detectors (physics.ins-det), Calorimeter, High Energy Physics::Experiment, business
Abstract

Application Specific Integrated Circuits, ASICs, similar to those envisaged for the readout electronics of the central calorimeters of detectors for a future lepton collider have been exposed to high-energy electromagnetic showers. A salient feature of these calorimeters is that the readout electronics will be embedded into the calorimeter layers. In this article it is shown that interactions of shower particles in the volume of the readout electronics do not alter the noise pattern of the ASICs. No signal at or above the MIP level has been observed during the exposure. The upper limit at the 95% confidence level on the frequency of fake signals is smaller than 1 × 10 − 5 for a noise threshold of about 60% of a MIP. For ASICs with similar design to those which were tested, it can thus be largely excluded that the embedding of the electronics into the calorimeter layers compromises the performance of the calorimeters.

Published
2011
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5. Electromagnetic response of a highly granular hadronic calorimeter

Author

The CALICE collaboration, C Adloff, J Blaha, J -J Blaising, C Drancourt, A Espargilière, R Gaglione, N Geffroy, Y Karyotakis, J Prast, G Vouters, K Francis, J Repond, J Smith, L Xia, E Baldolemar, J Li, S T Park, M Sosebee, A P White, J Yu, Y Mikami, N K Watson, T Goto, G Mavromanolakis, M A Thomson, D R Ward, W Yan, D Benchekroun, A Hoummada, Y Khoulaki, M Benyamna, C Cârloganu, F Fehr, P Gay, S Manen, L Royer, G C Blazey, A Dyshkant, J G R Lima, V Zutshi, J -Y Hostachy, L Morin, U Cornett, D David, R Fabbri, G Falley, K Gadow, E Garutti, P Göttlicher, C Günter, S Karstensen, F Krivan, A -I Lucaci-Timoce, S Lu, B Lutz, I Marchesini, N Meyer, S Morozov, V Morgunov, M Reinecke, F Sefkow, P Smirnov, M Terwort, A Vargas-Trevino, N Wattimena, O Wendt, N Feege, J Haller, S Richter, J Samson, P Eckert, A Kaplan, H -Ch Schultz-Coulon, W Shen, R Stamen, A Tadday, B Bilki, E Norbeck, Y Onel, G W Wilson, K Kawagoe, S Uozumi, J A Ballin, P D Dauncey, A -M Magnan, H S Yilmaz, O Zorba, V Bartsch, M Postranecky, M Warren, M Wing, F Salvatore, E Calvo Alamillo, M -C Fouz, J Puerta-Pelayo, V Balagura, B Bobchenko, M Chadeeva, M Danilov, A Epifantsev, O Markin, R Mizuk, E Novikov, V Rusinov, E Tarkovsky, V Kozlov, Y Soloviev, P Buzhan, B Dolgoshein, A Ilyin, V Kantserov, V Kaplin, A Karakash, E Popova, S Smirnov, A Frey, C Kiesling, K Seidel, F Simon, C Soldner, L Weuste, J Bonis, B Bouquet, S Callier, P Cornebise, Ph Doublet, F Dulucq, M Faucci Giannelli, J Fleury, G Guilhem, H Li, G Martin-Chassard, F Richard, Ch de la Taille, R Pöschl, L Raux, N Seguin-Moreau, F Wicek, M Anduze, V Boudry, J-C Brient, D Jeans, P Mora de Freitas, G Musat, M Reinhard, M Ruan, H Videau, B Bulanek, J Zacek, J Cvach, P Gallus, M Havranek, M Janata, J Kvasnicka, D Lednicky, M Marcisovsky, I Polak, J Popule, L Tomasek, M Tomasek, P Ruzicka, P Sicho, J Smolik, V Vrba, J Zalesak, B Belhorma, H Ghazlane, K Kotera, M Nishiyama, T Takeshita, S Tozuka, T Buanes, G Eigen, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CALICE, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, Physics - Instrumentation and Detectors, International Linear Collider, Physics::Instrumentation and Detectors, FOS: Physical sciences, Scintillator, 01 natural sciences, 7. Clean energy, Optics, Silicon photomultiplier, 0103 physical sciences, Calibration, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, 010306 general physics, Instrumentation, Mathematical Physics, Large Hadron Collider, 010308 nuclear & particles physics, business.industry, Detector, Instrumentation and Detectors (physics.ins-det), Calorimeter, High Energy Physics::Experiment, business, Beam (structure)
Abstract

The CALICE collaboration is studying the design of high performance electromagnetic and hadronic calorimeters for future International Linear Collider detectors. For the hadronic calorimeter, one option is a highly granular sampling calorimeter with steel as absorber and scintillator layers as active material. High granularity is obtained by segmenting the scintillator into small tiles individually read out via silicon photo-multipliers (SiPM). A prototype has been built, consisting of thirty-eight sensitive layers, segmented into about eight thousand channels. In 2007 the prototype was exposed to positrons and hadrons using the CERN SPS beam, covering a wide range of beam energies and incidence angles. The challenge of cell equalization and calibration of such a large number of channels is best validated using electromagnetic processes. The response of the prototype steel-scintillator calorimeter, including linearity and uniformity, to electrons is investigated and described.

Published
2011
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6. Study of the interactions of pions in the CALICE silicon-tungsten calorimeter prototype

Author

The CALICE collaboration, C Adloff, Y Karyotakis, J Repond, J Yu, G Eigen, Y Mikami, N K Watson, J A Wilson, T Goto, G Mavromanolakis, M A Thomson, D R Ward, W Yan, D Benchekroun, A Hoummada, Y Khoulaki, J Apostolakis, A Ribon, V Uzhinskiy, M Benyamna, C Cârloganu, F Fehr, P Gay, G C Blazey, D Chakraborty, A Dyshkant, K Francis, D Hedin, J G Lima, V Zutshi, J -Y Hostachy, K Krastev, L Morin, N D'Ascenzo, U Cornett, D David, R Fabbri, G Falley, K Gadow, E Garutti, P Göttlicher, T Jung, S Karstensen, A -I Lucaci-Timoce, B Lutz, N Meyer, V Morgunov, M Reinecke, F Sefkow, P Smirnov, A Vargas-Trevino, N Wattimena, O Wendt, N Feege, M Groll, J Haller, R -D Heuer, S Morozov, S Richter, J Samson, A Kaplan, H -Ch Schultz-Coulon, W Shen, A Tadday, B Bilki, E Norbeck, Y Onel, E J Kim, G Kim, D-W Kim, K Lee, S C Lee, K Kawagoe, Y Tamura, P D Dauncey, A -M Magnan, H Yilmaz, O Zorba, V Bartsch, M Postranecky, M Warren, M Wing, M G Green, F Salvatore, M Bedjidian, R Kieffer, I Laktineh, M -C Fouz, D S Bailey, R J Barlow, M Kelly, R J Thompson, M Danilov, E Tarkovsky, N Baranova, D Karmanov, M Korolev, M Merkin, A Voronin, A Frey, S Lu, K Seidel, F Simon, C Soldner, L Weuste, J Bonis, B Bouquet, S Callier, P Cornebise, Ph Doublet, M Faucci Giannelli, J Fleury, H Li, G Martin-Chassard, F Richard, Ch de la Taille, R Poeschl, L Raux, N Seguin-Moreau, F Wicek, M Anduze, V Boudry, J-C Brient, G Gaycken, D Jeans, P Mora de Freitas, G Musat, M Reinhard, A Rougé, M Ruan, J-Ch Vanel, H Videau, K-H Park, J Zacek, J Cvach, P Gallus, M Havranek, M Janata, M Marcisovsky, I Polak, J Popule, L Tomasek, M Tomasek, P Ruzicka, P Sicho, J Smolik, V Vrba, J Zalesak, B Belhorma, M Belmir, S W Nam, I H Park, J Yang, J -S Chai, J -T Kim, G -B Kim, J Kang, Y -J Kwon, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CALICE, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Monte Carlo method, Hadron, FOS: Physical sciences, Electron, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Pion, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], CALICE, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], ddc:610, Detectors and Experimental Techniques, 010306 general physics, Nuclear Experiment, Instrumentation, Mathematical Physics, Physics, Large Hadron Collider, Calorimeter (particle physics), 010308 nuclear & particles physics, Detector, Instrumentation and Detectors (physics.ins-det), Physics::Accelerator Physics, High Energy Physics::Experiment
Abstract

A prototype silicon-tungsten electromagnetic calorimeter for an ILC detector was tested in 2007 at the CERN SPS test beam. Data were collected with electron and hadron beams in the energy range 8 to 80 GeV. The analysis described here focuses on the interactions of pions in the calorimeter. One of the main objectives of the CALICE program is to validate the Monte Carlo tools available for the design of a full-sized detector. The interactions of pions in the Si-W calorimeter are therefore confronted with the predictions of various physical models implemented in the GEANT4 simulation framework. A prototype silicon-tungsten electromagnetic calorimeter for an ILC detector was tested in 2007 at the CERN SPS test beam. Data were collected with electron and hadron beams in the energy range 8 to 80 GeV. The analysis described here focuses on the interactions of pions in the calorimeter. One of the main objectives of the CALICE program is to validate the Monte Carlo tools available for the design of a full-sized detector. The interactions of pions in the Si-W calorimeter are therefore confronted with the predictions of various physical models implemented in the GEANT4 simulation framework.

Published
2010
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7. Construction and Commissioning of the CALICE Analog Hadron Calorimeter Prototype

Author

The CALICE collaboration, C Adloff, Y Karyotakis, J Repond, A Brandt, H Brown, K De, C Medina, J Smith, J Li, M Sosebee, A White, J Yu, T Buanes, G Eigen, Y Mikami, O Miller, N K Watson, J A Wilson, T Goto, G Mavromanolakis, M A Thomson, D R Ward, W Yan, D Benchekroun, A Hoummada, Y Khoulaki, M Oreglia, M Benyamna, C Cârloganu, P Gay, J Ha, G C Blazey, D Chakraborty, A Dyshkant, K Francis, D Hedin, G Lima, V Zutshi, V A Babkin, S N Bazylev, Yu I Fedotov, V M Slepnev, I A Tiapkin, S V Volgin, J -Y Hostachy, L Morin, N D'Ascenzo, U Cornett, D David, R Fabbri, G Falley, N Feege, K Gadow, E Garutti, P Göttlicher, T Jung, S Karstensen, V Korbel, A -I Lucaci-Timoce, B Lutz, N Meyer, V Morgunov, M Reinecke, S Schätzel, S Schmidt, F Sefkow, P Smirnov, A Vargas-Trevino, N Wattimena, O Wendt, M Groll, R -D Heuer, S Richter, J Samson, A Kaplan, H -Ch Schultz-Coulon, W Shen, A Tadday, B Bilki, E Norbeck, Y Onel, E J Kim, G Kim, D-W Kim, K Lee, S C Lee, K Kawagoe, Y Tamura, J A Ballin, P D Dauncey, A -M Magnan, H Yilmaz, O Zorba, V Bartsch, M Postranecky, M Warren, M Wing, M Faucci Giannelli, M G Green, F Salvatore, R Kieffer, I Laktineh, M C Fouz, D S Bailey, R J Barlow, R J Thompson, M Batouritski, O Dvornikov, Yu Shulhevich, N Shumeiko, A Solin, P Starovoitov, V Tchekhovski, A Terletski, B Bobchenko, M Chadeeva, M Danilov, O Markin, R Mizuk, E Novikov, V Rusinov, E Tarkovsky, V Andreev, N Kirikova, A Komar, V Kozlov, Y Soloviev, A Terkulov, P Buzhan, B Dolgoshein, A Ilyin, V Kantserov, V Kaplin, A Karakash, E Popova, S Smirnov, N Baranova, E Boos, L Gladilin, D Karmanov, M Korolev, M Merkin, A Savin, A Voronin, A Topkar, A Frey, C Kiesling, S Lu, K Prothmann, K Seidel, F Simon, C Soldner, L Weuste, B Bouquet, S Callier, P Cornebise, F Dulucq, J Fleury, H Li, G Martin-Chassard, F Richard, Ch de la Taille, R Poeschl, L Raux, M Ruan, N Seguin-Moreau, F Wicek, M Anduze, V Boudry, J-C Brient, G Gaycken, R Cornat, D Jeans, P Mora de Freitas, G Musat, M Reinhard, A Rougé, J-Ch Vanel, H Videau, K-H Park, J Zacek, J Cvach, P Gallus, M Havranek, M Janata, J Kvasnicka, M Marcisovsky, I Polak, J Popule, L Tomasek, M Tomasek, P Ruzicka, P Sicho, J Smolik, V Vrba, J Zalesak, Yu Arestov, V Ammosov, B Chuiko, V Gapienko, Y Gilitski, V Koreshev, A Semak, Yu Sviridov, V Zaets, B Belhorma, M Belmir, A Baird, R N Halsall, S W Nam, I H Park, J Yang, J -S Chai, J -T Kim, G -B Kim, Y Kim, J Kang, Y -J Kwon, I Kim, T Lee, J Park, J Sung, S Itoh, K Kotera, M Nishiyama, T Takeshita, S Weber, C Zeitnitz, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CALICE, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

Subjects
Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Hadron, FOS: Physical sciences, Scintillator, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Silicon photomultiplier, Optics, 0103 physical sciences, Calibration, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], CALICE, ddc:610, Fermilab, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, 010306 general physics, Instrumentation, Mathematical Physics, Physics, Large Hadron Collider, 010308 nuclear & particles physics, business.industry, DESY, Instrumentation and Detectors (physics.ins-det), Physics::Accelerator Physics, High Energy Physics::Experiment, business
Abstract

An analog hadron calorimeter (AHCAL) prototype of 5.3 nuclear interaction lengths thickness has been constructed by members of the CALICE Collaboration. The AHCAL prototype consists of a 38-layer sandwich structure of steel plates and highly-segmented scintillator tiles that are read out by wavelength-shifting fibers coupled to SiPMs. The signal is amplified and shaped with a custom-designed ASIC. A calibration/monitoring system based on LED light was developed to monitor the SiPM gain and to measure the full SiPM response curve in order to correct for non-linearity. Ultimately, the physics goals are the study of hadron shower shapes and testing the concept of particle flow. The technical goal consists of measuring the performance and reliability of 7608 SiPMs. The AHCAL was commissioned in test beams at DESY and CERN. The entire prototype was completed in 2007 and recorded hadron showers, electron showers and muons at different energies and incident angles in test beams at CERN and Fermilab., Comment: 36 pages, 32 figures

Published
2010
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8. Response of the CALICE Si-W electromagnetic calorimeter physics prototype to electrons

Author

Ch. de la Taille, N. T. Meyer, T. Jung, I. H. Park, Y. Karyotakis, K. Francis, J. Zalesak, C. Cârloganu, H. Videau, O. Miller, F. Salvatore, Djamel Eddine Boumediene, C. M. Hawkes, M. Faucci Giannelli, Shih-Chang Lee, M. Belmir, E. Norbeck, Y. J. Kwon, Dev P. Chakraborty, J. Popule, O. Wendt, M. Krim, M. Postranecky, A. A. Voronin, G. C. Blazey, J. Zacek, S. Richter, Kyong Sei Lee, P. Mora e Freitas, V. Morgunov, Riccardo Fabbri, M. Bedjidian, N. Brun, R. Poeschl, Ki-Hyeon Park, Erika Garutti, Francois Richard, S. Lu, D. David, D-W. Kim, H. Yilmaz, G. Falley, G. Lima, F. Wicek, Petr Gallus, J. Cvach, Michal Marcisovsky, B. Lutz, C. Adloff, M. Tomášek, Geun-Bum Kim, B. Belhorma, A. Frey, D. S. Bailey, Jose Repond, A. Tadday, L. Raux, R. J. Barlow, Driss Benchekroun, Johannes Haller, A. I. Lucaci-Timoce, Abdeslam Hoummada, F. Morisseau, P. Ruzicka, P. A. Smirnov, Vaclav Vrba, Petr Sicho, V. Korbel, I. Polak, A. Kaplan, A. Vargas-Trevino, M. Janata, Imad Baptiste Laktineh, N. I. Baek, K. Prothmann, Goetz Gaycken, J. Smolik, P. D. Dauncey, J.Ch. Vanel, E. Tarkovsky, A.S. Dyshkant, N. Seguin-Moreau, Jong-Sung Yu, W. Yan, J. Fleury, J-Y. Hostachy, G. Mavromanolakis, Yasar Onel, M. Merkin, Burak Bilki, M. Reinecke, J. C. Brient, M. Anduze, D. A. Bowerman, R. D. Heuer, Kiyotomo Kawagoe, J. H. Kang, Nicola D'Ascenzo, P. Göttlicher, M. Reinhard, F. Sefkow, Y. Tamura, Miroslav Havranek, D. Karmanov, U. Cornett, M. Groll, B. Bouquet, N. Baranova, Frank Simon, Hui Li, M. A. Thomson, E.J. Kim, G. Musat, M. Korolev, J T Kim, J. A. Wilson, G. Eigen, J. Samson, M R M Warren, N. K. Watson, V. Zutshi, Vincent Boudry, R. Kieffer, Jong-Seo Chai, Y. Mikami, S. W. Nam, R. J. Thompson, Anne-Marie Magnan, D. R. Ward, M. G. Green, K. Gadow, O. Zorba, M. Wing, S. Karstensen, L. Morin, N. Wattimena, V. Bartsch, M. Benyamna, S. Callier, T. Goto, P. Cornebise, D. Hedin, Michael Kelly, Wei Shen, H. Ch Schultz-Coulon, L. Tomášek, A. Rougé, N. Feege, M. Danilov, J. Yang, Manqi Ruan, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CALICE, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Accelerator Physics (physics.acc-ph), Nuclear and High Energy Physics, Particle physics, Physics - Instrumentation and Detectors, Silicon detector, International Linear Collider, Physics::Instrumentation and Detectors, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], FOS: Physical sciences, Electron, 01 natural sciences, 7. Clean energy, Nuclear physics, Electromagnetic calorimeter, 0103 physical sciences, CALICE, ddc:530, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Nuclear Experiment, physics.ins-det, Instrumentation, Physics, Large Hadron Collider, 010308 nuclear & particles physics, Detector, Linearity, Instrumentation and Detectors (physics.ins-det), 3. Good health, Semiconductor detector, ILC, Electron reconstruction, 13. Climate action, Cathode ray, Physics::Accelerator Physics, Physics - Accelerator Physics, High Energy Physics::Experiment
Abstract

A prototype Silicon-Tungsten electromagnetic calorimeter (ECAL) for an International Linear Collider (ILC) detector was installed and tested during summer and autumn 2006 at CERN. The detector had 6480 silicon pads of dimension 1x1 cm^2. Data were collected with electron beams in the energy range 6 to 45 GeV. The analysis described in this paper focuses on electromagnetic shower reconstruction and characterises the ECAL response to electrons in terms of energy resolution and linearity. The detector is linear to within approximately the 1% level and has a relative energy resolution of (16.6 +- 0.1)/ \sqrt{E(GeV}) + 1.1 +- 0.1 (%). The spatial uniformity and the time stability of the ECAL are also addressed., 21 pages, 17 figs

Published
2009
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10. Tests of a Particle Flow Algorithm with CALICE test beam data

Author

The CALICE collaboration, C Adloff, J Blaha, J -J Blaising, C Drancourt, A Espargilière, R Gaglione, N Geffroy, Y Karyotakis, J Prast, G Vouters, K Francis, J Repond, J Smith, L Xia, E Baldolemar, J Li, S T Park, M Sosebee, A P White, J Yu, T Buanes, G Eigen, Y Mikami, N K Watson, T Goto, G Mavromanolakis, M A Thomson, D R Ward, W Yan, D Benchekroun, A Hoummada, Y Khoulaki, M Benyamna, C Cârloganu, F Fehr, P Gay, S Manen, L Royer, G C Blazey, A Dyshkant, J G R Lima, V Zutshi, J -Y Hostachy, L Morin, U Cornett, D David, R Fabbri, G Falley, K Gadow, E Garutti, P Göttlicher, C Günter, S Karstensen, F Krivan, A -I Lucaci-Timoce, S Lu, B Lutz, I Marchesini, N Meyer, S Morozov, V Morgunov, M Reinecke, F Sefkow, P Smirnov, M Terwort, A Vargas-Trevino, N Wattimena, O Wendt, N Feege, J Haller, S Richter, J Samson, P Eckert, A Kaplan, H -Ch Schultz-Coulon, W Shen, R Stamen, A Tadday, B Bilki, E Norbeck, Y Onel, G W Wilson, K Kawagoe, S Uozumi, P D Dauncey, A -M Magnan, M Wing, F Salvatore, E Calvo Alamillo, M -C Fouz, J Puerta-Pelayo, V Balagura, B Bobchenko, M Chadeeva, M Danilov, A Epifantsev, O Markin, R Mizuk, E Novikov, V Rusinov, E Tarkovsky, N Kirikova, V Kozlov, Y Soloviev, P Buzhan, B Dolgoshein, A Ilyin, V Kantserov, V Kaplin, A Karakash, E Popova, S Smirnov, A Frey, C Kiesling, K Seidel, F Simon, C Soldner, L Weuste, J Bonis, B Bouquet, S Callier, P Cornebise, Ph Doublet, F Dulucq, M Faucci Giannelli, J Fleury, H Li, G Martin-Chassard, F Richard, Ch de la Taille, R Pöschl, L Raux, N Seguin-Moreau, F Wicek, M Anduze, V Boudry, J-C Brient, D Jeans, P Mora de Freitas, G Musat, M Reinhard, M Ruan, H Videau, B Bulanek, J Zacek, J Cvach, P Gallus, M Havranek, M Janata, J Kvasnicka, D Lednicky, M Marcisovsky, I Polak, J Popule, L Tomasek, M Tomasek, P Ruzicka, P Sicho, J Smolik, V Vrba, J Zalesak, B Belhorma, H Ghazlane, T Takeshita, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CALICE, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Particle physics, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Nuclear Theory, Hadron, Monte Carlo method, FOS: Physical sciences, Jet (particle physics), 01 natural sciences, law.invention, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Pion, law, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, 010306 general physics, Collider, Nuclear Experiment, Instrumentation, Mathematical Physics, Physics, 010308 nuclear & particles physics, Instrumentation and Detectors (physics.ins-det), Calorimeter, High Energy Physics::Experiment, Algorithm, Beam (structure), Lepton
Abstract

The studies presented in this paper provide a first experimental test of the Particle Flow Algorithm (PFA) concept using data recorded in high granularity calorimeters. Pairs of overlaid pion showers from CALICE 2007 test beam data are reconstructed by the PandoraPFA program developed to implement PFA for a future lepton collider. Recovery of a neutral hadron's energy in the vicinity of a charged hadron is studied. The impact of the two overlapping hadron showers on energy resolution is investigated. The dependence of the confusion error on the distance between a 10 GeV neutral hadron and a charged pion is derived for pion energies of 10 and 30 GeV which are representative of a 100 GeV jet. The comparison of these test beam data results with Monte Carlo simulation is done for various hadron shower models within the GEANT4 framework. The results for simulated particles and for beam data are in good agreement thereby providing support for previous simulation studies of the power of Particle Flow Calorimetry at a future lepton collider. CALICE 2007 test beam data were used to test the PandoraPFA program. The program capability to recover a neutral hadron energy in the vicinity of a charged hadron was studied. The impact of overlapping of two hadron showers on energy resolution was investigated. The dependence of the confusion error on the distance between a 10 GeV neutral hadron and a charged pion was derived for pion energies of 10 and 30 GeV which are representative of a 100 GeV jet. The comparison of these test beam data results with Monte Carlo simulation was done for LHEP and QGSP BERT physics lists. The probability of correct recovering of neutral hadron energy has been calculated. The dependence of the confusion error on the neutral hadron energy was also studied. The confusion error averaged over 100 GeV jet fragment energies has been estimated for the case of one neutral and one charged hadron.

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11. Management of Giant Thyroid Tumors in Patients with Multiple Comorbidities in a Tertiary Head and Neck Surgery Center.

Author

Vrinceanu D, Dumitru M, Marinescu A, Serboiu C, Musat G, Radulescu M, Popa-Cherecheanu M, Ciornei C, and Manole F

Abstract

Background/Objectives : The thyroid gland can represent the seat of development for giant tumors exceeding 10 cm in diameter. A retrospective analysis on 21 cases of giant thyroid tumors with comorbidities, operated in the ENT Department of the Bucharest University Emergency Hospital has been conducted. Methods : Giant benign tumors accounted for 28.57% of the cases studied and reached gigantic volumes in an average time interval of 3 years, with an average resection piece weight of 318 g. Malignant tumors accounted for 71.43%, with an average duration of evolution of 7 years, with an average resection piece weight of 581 g. Results : Dysphagia was present in all patients, dyspnea in 47.61% and dysphonia in 38.09% of cases. Total thyroidectomy is the gold standard in giant thyroid tumors, associated with radical neck dissection, extended to groups VI and VII in malignant tumors. In 10 of 11 cases of giant malignant thyroid tumors (90.90%), without anaplastic thyroid carcinoma, the survival at 5 years after multimodal oncologic treatment was favorable. Anticoagulant treatment increased the risk of postoperative reversible recurrent laryngeal nerve lesion. Conclusions : The management of giant thyroid tumors in patients with multiple comorbidities needs a multidisciplinary team including endocrinologist, radiologist, anesthesiologist, pathologist, ENT surgeon, thoracic surgeon, oncologist and radiotherapist.

Published
2024
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12. Local Allergic Rhinitis-A Challenge for Allergology and Otorhinolaryngology Cooperation (Scoping Review).

Author

Berghi O, Dumitru M, Cergan R, Musat G, Serboiu C, and Vrinceanu D

Abstract

Local allergic rhinitis (LAR) represents a medical provocation for allergists and otorhinolaryngologists. LAR is considered to be a subtype of allergic rhinitis (AR) that affects a great percentage of patients who were, for decades, diagnosed as having chronic non-allergic rhinitis. The clinical picture is represented by rhinorrhea, sneezing, and nasal itching correlated with specific pollen season or dust, mold, or pet interior exposure. Usual assessment of AR (skin prick testing and serum IgE assessment) produces negative results. Specialized centers in allergology and ENT around the globe use a nasal allergen challenge, assessment of local IgE, basophil activation test (BAT), and nasal cytology in the diagnostic approach to the disease, taking into account their current limitations. The impact of LAR on quality-of-life indicators is the same as in AR. Treatment for LAR is similar to that for AR and is the same as for AR: allergen exposure avoidance, drug therapy, and allergen immunotherapy. This scoping review gathers the current up-to-date open access evidence available on PubMed on the subject of LAR.

Published
2024
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13. Surgical Endoscopic Treatment of Odontogenic Sinusitis.

Author

Preda MA, Musat G, and Sarafoleanu C

Subjects
Humans, Neoplasm Recurrence, Local, Retrospective Studies, Treatment Outcome, Adult, Maxillary Sinusitis surgery, Maxillary Sinusitis etiology, Sinus Floor Augmentation adverse effects, Sinusitis complications
Abstract

Introduction: Odontogenic sinusitis is a frequent disease of the maxillary sinus, resulting from a dental inflammatory condition or a foreign body migrated in the sinus cavity. We performed a clinical retrospective study aimed to review the two surgical endoscopic approaches for odontogenic maxillary sinusitis middle and inferior meatotomy, in terms of realistic indications, efficacy, outcomes, and possible complications. Materials and Methods: In our study, we included a number of 400 patients with odontogenic maxillary sinusitis divided into two groups, treated in our hospital over five years, from January 2019 to December 2023. The patients included in this research were over 18 years old, diagnosed with odontogenic maxillary sinusitis, and underwent either middle meatal antrostomy or inferior meatotomy. Results: We examined the medical records of 400 patients. The vast majority of patients had a history of dental interventions, and the most affected tooth was the first maxillary molar. The symptoms at admission were typical for sinusitis: nasal obstruction, anterior or posterior rhinorrhea, hyposmia to anosmia, cacosmia, and pain or facial pressure. 80% of the patients in the study underwent middle meatal antrostomy, while 20% underwent inferior meatotomy. There were no significant differences between these two approaches in terms of efficacy, complication rates, recovery, or relapses. The complications that occurred after the surgical treatment were minor and with a very low frequency. The most reported were middle meatus synechiae and the persistence of the meatotomy ostium, with mucus recirculation (in patients with inferior meatotomy). Conclusions: Endoscopic surgical treatment of odontogenic maxillary sinusitis can be done as middle or inferior meatotomy, each having specific indications. The maxillary antrostomy is preferred in the majority of cases, as it is a procedure in which the natural ostium of the maxillary sinus is enlarged, thereby maintaining the natural drainage pathway of the sinus. However, the inferior meatotomy is preferred in the case of foreign bodies or maxillary sinus retention cysts localized at the level of the sinus floor or in the alveolar or lateral recesses, or as part of a combined approach (inferior and middle meatotomy), when the ablation of a "fungus ball" is required., (Celsius.)

Published
2024
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14. Severe DRESS syndrome after carbamazepine intake in a case with multiple addictions: A case report.

Author

Vrinceanu D, Dumitru M, Stefan A, Neagos A, Musat G, and Nica EA

Abstract

A case is presented of a male with drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by carbamazepine intake. The patient presented all the elements of DRESS syndrome: Skin reaction, fever, enlargement of the lymph nodes, increased eosinophils and lymphocytes, with associated organ dysfunctions. The patient was admitted with acute laryngeal edema and imminence of respiratory insufficiency. The escalation of symptoms for this syndrome is typical, even after the administering of the the culprit medicine has ceased. However, in this case, the most difficult aspect was the complex treatment scheme prior to admission. All medical compounds involved in the background treatment were substituted with other substances in order to control the immune response. Current knowledge regarding DRESS is reviewed and possible influence of various etiologies over the present case are discussed. Clinicians should be aware of this rare situation with life-threatening potential. We benefited from the advantage of reuniting the knowledge of a complex team of experts from various tertiary emergency units in Romania., (Copyright © 2020, Spandidos Publications.)

Published
2020
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15. Rare amyloidoma of the tongue base: A case report and review of the literature.

Author

Musat G, Evsei A, Calina D, Docea AO, Doukas SG, Vageli DP, Nepka C, Spandidos DA, and Mitroi M

Abstract

Localized amyloidosis is a rare condition characterized by the deposition of misfolding protein in a tissue, without other systemic manifestations. Only a small number of cases of localized amyloidosis of the tongue have been reported to date, in contrast to systemic amyloidosis, in which localization on the tongue is common. This study presents a rare case of localized amyloidosis of the tongue (amyloidoma) and provides a summary of the known literature of localized amyloidosis. This study describes the case of a 36-year-old female who presented with a swelling of the tongue base. The diagnosis of amyloidoma was made based on the findings of the physical examination, head and neck MRI findings and the histopathological examination with Congo red stain under polarized light. The histopathological diagnosis was as follows: Localized lambda light-chain amyloidosis. A thorough physical examination was performed by the ENT and Hematology/Oncology departments, without revealing signs of systemic disease. A series of hematological and imaging tests were also performed to verify that there was no sign of systemic involvement. The patient declined surgical excision and the 2-year follow-up did not reveal any changes in tumor dimension. Although the etiology of localized amyloidosis is yet not clear, the prolonged reaction of tissue plasma cells to environmental antigens may be a causative factor for the initiation of the neoplastic process., (Copyright: © Musat et al.)

Published
2020
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16. Differences in the distribution of CD20, CD3, CD34 and CD45RO in nasal mucosa and polyps from patients with chronic rhinosinusitis.

Author

Mitroi M, Albulescu D, Capitanescu A, Docea AO, Musat G, Mitroi G, Zlatian O, Tsatsakis A, Tzanakakis G, Spandidos DA, and Calina D

Subjects
Adolescent, Adult, Biomarkers, Child, Child, Preschool, Chronic Disease, Eosinophils immunology, Eosinophils metabolism, Eosinophils pathology, Female, Humans, Immunohistochemistry, Infant, Infant, Newborn, Lymphocytes immunology, Lymphocytes metabolism, Lymphocytes pathology, Male, Middle Aged, Young Adult, Nasal Mucosa metabolism, Nasal Mucosa pathology, Nasal Polyps etiology, Nasal Polyps metabolism, Rhinitis complications, Rhinitis metabolism, Sinusitis complications, Sinusitis metabolism
Abstract

The present study focused on the assessment of the inflammatory infiltrate that characterizes nasal polyps in patients with chronic rhinosinusitis and nasal polyposis. Inflammatory cell type was determined using specific markers. This evaluation was made possible by determining the expression of the following markers: CD20, a marker of B lymphocytes [using activated T cells (ATC) armed with CD20 antibody]; CD3, a marker of T lymphocytes (using ATC armed with anti‑CD3 antibody); CD45, the leukocyte common antigen (using ATC armed with anti‑CD45 antibody; and CD34, for the microvasculature of the nasal polyp (using anti‑CD34 antibody). The diagnosis of chronic rhinosinusitis with nasal polyps (CRSwNP) was made according to current EPOS guidelines based on patient history, clinical examination and nasal endoscopy. We examined surgically resected nasal polyps from 127 patients diagnosed with CRSwNP, who benefited from surgical procedures at the Department of Otorhinolaryngology of our institution. The polyps were analyzed at the Department of Pathology of our institution utilizing histopathological and immunohistochemical methods as follows: Firstly, the tissues were paraffin‑impregnated, sectioned and stained with hematoxylin and eosin. We then examined the expression of CD3, CD20, CD34 and CD45RO by immunohistochemistry with soluble labeled streptavidin biotin (LSAB)/horseradish peroxidase (HRP) complexes. We observed the following histopathological changes: The structure of the epithelium was evidenced by collagenous subjacent stroma with mixed areas, sometimes associated with hyaline zones. In all types of polyps, we also observed a diffuse underlayer or periglandular lymphoplasmacytic in filtrate composed predominantly from T lymphocytes and eosinophils. The histopathological changes suggest the chronic inflammation of the sinus mucosa, which was diffusely distributed in allergic polyps and with nodular distribution in fibro‑inflammatory polyps. The number of B lymphocytes was greater in the fibro‑inflammatory polyps. On the whole, the findings of this study indicate that the inflammatory infiltrate in nasal polyps from patients with CRSwNP is mainly composed of T cells and eosinophils in all types of polyposis. In addition, a diffuse distribution of allergic polyps and the nodular distribution of fibro‑inflammatory polyps, and the hyperplasia of the seromucous glands was observed. The determination of CD20, CD3, CD34 and CD45RO could be used to assess the inflammatory infiltrate of the nasal poplyps in these patients.

Published
2019
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17. Treatment of Meniere's disease with intratympanic dexamethazone plus high dosage of betahistine.

Author

Albu S, Nagy A, Doros C, Marceanu L, Cozma S, Musat G, and Trabalzini F

Subjects
Adult, Drug Therapy, Combination, Female, Humans, Injection, Intratympanic, Male, Meniere Disease complications, Prospective Studies, Treatment Outcome, Vertigo etiology, Anti-Inflammatory Agents therapeutic use, Betahistine therapeutic use, Dexamethasone therapeutic use, Histamine Agonists therapeutic use, Meniere Disease diet therapy, Vertigo prevention & control
Abstract

Purpose: The aim of the present study was to assess if the combined therapy of intratympanic dexamethasone (ITD) and high dosage of betahistine (HDBH) is able to provide increased vertigo control compared to ITD alone in patients suffering from definite unilateral Meniere's disease (MD)., Materials and Methods: Consecutive MD patients were enrolled and randomly divided in two groups, each comprising 33 cases. Group A received a combination of ITD and identical-appearing placebo pills while Group B received a combination of ITD and HDBH. ITD protocol consisted of three consecutive daily injections. HDBH comprised 144mg/day (48mg tid). The main outcome measures were: 1) vertigo class, pure tone average (PTA), speech discrimination score (SDS) and Functional Level Score (FLS) according to the American Academy of Otolaryngology-Head and Neck Surgery criteria; 2) complete and substantial vertigo control according to the Kaplan-Meier survival method., Results: Sixty two patients completed the 24-month follow-up. A complete vertigo control was achieved in 14 patients (44%) from Group A and in 22 patients (73.3%) from Group B, statistically significant (p=0.01). Complete vertigo relief is also significant according to the Kaplan-Meier method: p=0.027, log rank test. Substantial vertigo control was obtained in 21 patients (65.6%) in Group A and 27 patients (90%) in Group B. The difference is statistically significant, p=0.02. The difference is significant according to the Kaplan-Meier method: p=0.035, log rank test. No significant differences between hearing levels and tinnitus scores were demonstrated between the groups., Conclusions: Our preliminary results demonstrate that complete and substantial vertigo control is significantly higher in patients treated with a combination of HDBH and ITD., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Published
2016
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