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Background: Arteriovenous grafts (AVGs) are used for patients deemed unsuitable for the creation of an autogenous arteriovenous fistula (AVF) or unable to await maturation of the AVF before starting hemodialysis. However, AVGs are prone to infection and thrombosis resulting in low long-term patency rates. The novel aXess Hemodialysis Graft consists of porous polymeric biomaterial allowing the infiltration by cells and the growth of neotissue, while the graft itself is gradually absorbed, ultimately resulting in a fully functional natural blood vessel. The Pivotal Study will examine the long-term effectiveness and safety of the aXess Hemodialysis Graft. Methods: The Pivotal Study is a prospective, single-arm, multicenter study that will be conducted in 110 subjects with end-stage renal disease who are not deemed suitable for the creation of an autogenous vascular access. The primary efficacy endpoint will be the primary patency rate at 6 months. The primary safety endpoint will be the freedom from device-related serious adverse events at 6 months. The secondary endpoints will include the procedural success rate, time to first cannulation, patency rates, the rate of access-related interventions to maintain patency, the freedom from device-related serious adverse events and the rate of access site infections. Patients will be followed for 60 months. An exploratory Health Economic and Outcomes Research sub-study will determine potential additional benefits of the aXess graft to patients, health care institutions, and reimbursement programs. Discussion: The Pivotal study will examine the long-term performance and safety of the aXess Hemodialysis Graft and compare the outcome measures with historical data obtained with other graft types and autogenous AVFs. Potential advantages may include superior long-term patency rates and lower infection rates versus currently available AVGs and a shorter time to first cannulation compared to an autologous AVF. As such, the aXess Hemodialysis Graft may fulfill an unmet clinical need in the field of hemodialysis access.

Study question Can metabolic profiling predict embryos at risk of chromosomal abnormalities and how are these reflected in the ultrustructure and cytoskeleton? Summary answer Different metabolic profiles are observed between normal and aneuploid/chaotic embryos which are linked to altered mitochondrial and other organelles’ structure/function and spindle and nuclear abnormalities. What is known already One of the greatest challenges in IVF is the selection of the best ‘fit’ embryo for implantation in a non-invasive way. Down’s syndrome embryos and Monosomy 21 embryos have previously been shown to have differential expression of metabolites compared to normal embryos, but limited studies, have investigated in detail the metabolic profiling of embryos with other abnormalities in comparison to chromosomally normal embryos or their reflection in the ultrustructure and the cytoskeleton. Study design, size, duration Culture media collected on day 3 from 200 embryos which underwent PGT-A, were analysed by hydrophilic interaction liquid chromatography tandem mass spectrometry (HILIC-MS/MS). The chromosomally normal embryos were transferred to the uterus (1–2 embryos/ET) or still remain vitrified for clinical use and 120 of the embryos that were diagnosed with chromosomal abnormalities were either processed for spindle/chromosome configurations analysis (n = 60) by confocal laser scanning microscopy(CLSM) or for ultrastructural analysis (n = 60) by Transmission Electron Microscopy(TEM). Participants/materials, setting, methods Metabolic profiling was conducted in a Forensic Toxicology Laboratory by HILIC-MS/MS (100 metabolites). Spindle Chromosome Configuration analysis was conducted in an academic hospital after methanol fixation and immunostaining with α-tubulin, γ-tubulin, acetylated-tubulin antibodies and DAPI or/ PI to visualise DNA. Ultrastructure analysis by TEM was carried out in a Histology/Embryology Laboratory following embryo fixation in 3% glutaraldehyde, 1% osmium tetroxide, washes in PBS and staining with 1% aqueous uranyl acetate. Main results and the role of chance This study provides screening for >100 primary metabolites using HILIC-MS/MS in a single run of 40 minutes. Characteristic patient specific metabolic profiles were observed which differed between normal embryos that had resulted in a viable pregnancy and aneuploid and chaotic embryos. Logistic regression analysis revealed a number of metabolites that had a high predictive value including Isoleucine, lysine and glucose and models were created in combination with embryo score which in the future could serve as non-invasive markers for the detection of chromosomal abnormalities before embryo transfer. TEM analysis revealed differences in the quality of cells and organelle activity which were reflected in the embryo metabolic profiles. Chaotic poor quality embryos showed a lower number of mitochondria, often with no cisternae, increased number of vacuoles, and frequently problems in junctions between cells. Aneuploid but well developed hatching blastocysts had mainly cells with good mitochondrial morphology/ activity, nice Golgi apparatus and well developed rough and smooth endoplasmic reticulum but depending on the aneuploidy involved, inner cell mass cells with limited organelles and occasionally lipofuscin droplets in the trophectoderm were evident. Nuclear and chromosomal abnormalities were interrelated through abnormalities in cytokinesis and spindle formation and reflected in the embryo metabolic profiles. Limitations, reasons for caution Although metabolic profiles were compared between normal and chromosomally abnormal embryos identified by PGT-A, all the normal embryos were transferred to the uterus or remain vitrified for clinical purposes and therefore the ultrastructure analysis and the spindle chromosome configuration analysis are based only on chromosomally abnormal embryos. Wider implications of the findings This study identified distinct differences in the metabolic profiles of normal and chromosomally abnormal embryos and provides unique metabolites which in the future could serve as non-invasive biomarkers for the detection of chromosomal abnormalities before embryo transfer. Trial registration number not applicable

Obstruction or occlusion of the central veins (Central venous disease, CVD) represents a major complication in hemodialysis patients (HD) limiting central venous access available for a central venous catheter placement. Endovascular treatment with percutaneous transluminal angioplasty (PTA) is the first therapeutic option to restore patency and gain access. This case presents our initial experience of a HD patient with CVD treated with a combination therapy of a balloon PTA to the left brachiocephalic trunk, through the right hepatic vein and standard catheter placement technique to the previously occluded junction of the left internal jugular vein to the left subclavian vein.

At present, campaign finance regulations may only be justified if their primary purpose is to prevent quid pro quo corruption or the appearance of corruption. References to the “appearance of corru...

Tourism is a phenomenon that dates back to ancient times. Ancient Greek philosophers recognised, adopted, and promoted the concept of rest-based tourism. Ecotourism is a particular type of tourism that connects with activities that take place in nature, without harming it, along with the herbal and animal wealth. According to estimates, the global ecotourism industry is currently booming due to various reasons, and it is becoming an important factor of sustainable regional development. This article presents the vision, work, and outcomes of project AdVENt, a project focusing natively in sustainable ecotourism through natural science and technological innovation. AdVENt’s study area includes the National Parks of Oiti (or Oeta) and Parnassus in Central Greece, where there is a remarkable native flora with a high endemism rate integrated with areas of cultural value and national and European hiking routes and paths of varying difficulty. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Stenosis or obstruction of neck great veins represent a frequent and severe complication in hemodialysis patients. Endovascular treatment with percutaneous transluminal angioplasty and/or stenting of these veins is the gold standard to restore patency. However, the jugular vein is frequently overstented in these cases and this might lead to persistent symptomatology of those patients also losing an access for future catheter placement. Herein, we present the 6-months performance of a Y-shaped stenting of the brachiocephalic and internal jugular vein leading to complete resolution of the symptoms, and maintenance of the jugular vein access.

The dominant narrative among scholars and political pundits characterizes American partisanship as overwhelmingly negative, portraying citizens as more repelled by the opposing party than attached to their own party. To assess the valence of partisan identity, we use various measures collected from several new and existing nationally representative surveys and behavioural outcomes obtained from two experiments. Our findings consistently depart from the negative partisanship narrative. For the majority of Americans, partisanship is either equally positive and negative or more positive than negative. Only partisan leaners stand out as negative partisans. We pair these observational findings with experimental data that differentiate between positive group behaviour and negative group behaviour in the partisan context. We find that the behavioural manifestations of party identity similarly include both positive and negative biases in balance, reinforcing our conclusion that descriptions of partisanship as primarily negative are exaggerated.

Background As oxygen and nutrient supply to the myocardium significantly decrease during ischemic periods, important changes occur regarding myocardial intermediary energy metabolism and metabolomic biomarkers. Purpose To identify patients at high risk for adverse cardiovascular (CV) events based on their metabolic signatures through combining clinical characteristics with established and novel biomarkers. Hence, we investigated the prognostic significance of protein biomarkers associated with CAD, namely Galectin-3, Adiponectin, Neutrophil gelatinase-associated lipocalin (NGAL) and Apolipoprotein B and A-1 (ApoB and A-1). Methods We conducted a sub-analysis of the Corlipid trial (NCT04580173) including patients who underwent coronary angiography in the cardiac catheterization laboratory of an academic tertiary hospital. Venous fasting blood samples were collected prior to coronary angiography and patients were followed-up for 12 months to record the occurrence of major adverse CV events. Galectin-3, adiponectin, NGAL and ApoB/A-1 ratio were measured by enzyme-linked immunosorbent assay (ELISA) in patients' venous blood samples. Serum concentrations were compared among CAD patient subgroups to assess the prognostic significance of these novel protein biomarkers in terms of cardiovascular mortality. Receiver operating characteristic (ROC) curves were also performed to calculate the corresponding area under the curve (AUC) for each biomarker and define their prognostic validity for patients with CAD. Results Out of 1140 total participants of the CorLipid trial, 534 patients with acute coronary syndrome (ACS) were finally included in the present analysis. Of them, 222 suffered from STEMI, 170 from NSTEMI and 141 from unstable angina. Higher ApoB/ApoA-1 and Galectin-3 serum concentrations were significantly linked with higher incidence of CV death in patients with NSTEMI during the one-year study follow up (p=0.049 and 0.027, respectively). Generated AUC of 0.713 (p=0.047) and 0.775 (p=0.002) indicate a potential utility in the quantification of those proteins as predictors of CV death in patients with NSTEMI. Analysis of serum adiponectin values did not yield any significant outcome (p>0.05). Lower NGAL concentrations were significantly correlated with CV death in patients with STEMI (p Conclusion(s) In patients with ACS, higher values of serum ApoB/ApoA-I and Galectin-3, as well as low NGAL concentrations were associated with higher prevalence of CV death in specific patient subgroups. Therefore, these serum biomarkers could be utilized for early risk-stratification and a more individualized approach in patients with ACS. Larger trials are warranted to confirm and bolster the significance and generalizability of our findings. Funding Acknowledgement Type of funding sources: Public grant(s) – EU funding. Main funding source(s): The specific project has been co-financed through the call for Proposals for the Action “Competitiveness, entrepreneurship & innovation” in the framework of the Operational Programme “Research, Create, Innovate” (project code: T1EDK-04005) of the Partnership Agreement for the Development Programme 2014-2020 by the European Social Fund (ESF) and Greek National funds. The project has undergone peer review and has been approved for funding, being awarded a grant of €873,821.00. The funder had no role in the design or conduct of the study, preparation, review or approval of the manuscript and decision to submit the manuscript for publication.

The affective, identity based, and often negative nature of partisan polarization in the United States has been a subject of much scholarly attention. Applying insights from recent work in social psychology, we employ three novel large-N, broadly representative online surveys, fielded over the course of 4 years, across two presidential administrations, to examine the extent to which this brand of polarization features a willingness to apply dehumanizing metaphors to out-partisans. We begin by looking at two different measures of dehumanization (one subtle and one more direct). This uncovers striking, consistent observational evidence that many partisans dehumanize members of the opposing party. We examine the relationship between dehumanization and other key partisan intensity measures, finding that it is most closely related to extreme affective polarization. We also show that dehumanization “predicts” partisan motivated reasoning and is correlated with respondent worldview. Finally, we present a survey experiment offering causal leverage to examine openness to dehumanization in the processing of new information about misdeeds by in- and out-partisans. Participants were exposed to identical information about a melee at a gathering, with the partisanship of those involved randomly assigned. We find pronounced willingness by both Democrats and Republicans to dehumanize members of the out-party. These findings shed considerable light on the nature and depth of modern partisan polarization.

We use a novel survey experiment with a broadly representative sample to reveal an important phenomenon in voter integration of campaign communications: preference-mediated partisan motivation. When evaluating the credibility of candidate position changes on minimum wage policy (a readily quantifiable and salient issue domain), partisans do not take a new stance at face value, apply universal skepticism, or simply afford more credibility to co-partisans. Instead, they process a candidate’s stance through an interaction between the voter’s partisan allegiance and their own policy preference. Partisans update more when a co-partisan moves closer to them than when the candidate shifts away from them. The opposite pattern emerges with the other party’s candidates: partisans tend to be more receptive if the candidate moves away from them. This feature of campaign message acceptance has profound implications for political communication and our understanding of partisan cognition.

To what extent do voters grasp “what goes with what” among key political objects as they attempt to understand the choices they face at the ballot box? Is recognition of these associations limited to only the most informed citizens? We design a novel conjoint classification experiment that minimizes partisan boosting and allows for the relative comparison of attribute effect when mapping voter associative networks, the cluster of attributes linked to parties and ideological labels. We ask respondents to ‘guess’ the party or ideology of hypothetical candidates with fully randomized issue priorities and biographical details. There is remarkable agreement among both high- and low-knowledge voters in linking issues to each party and ideology, suggesting this minimalist form of associative competence is more widely held in the mass public than perhaps previously thought. We find less agreement about biographical traits, which appear to pose greater informational challenges for voters. Notably, nearly identical issue priorities and traits are associated with party and ideology, indicating these two dimensions are largely fused in the minds of today’s American voters.

In metabolomics, retention prediction methods have been developed based on the structural and physicochemical characteristics of analytes. Such methods employ regression models, harnessing machine learning algorithms mapping experimentally derived retention time (t

Background Catheter-directed thrombolysis (CDT) is a therapeutic option with acceptable results in patients with acute limb ischemia (ALI) but with severe systemic or intracranial bleeding being the most significant clinical complication. The aim of the study is to collect and present direct results of CDT in patients treated for ALI. Methods Reports on CDT treatment in ALI until December 2016 were searched in PubMed using the keywords catheter direct thrombolysis, acute lower limb ischemia, and any combination. Results A total of 256 clinical trials were identified. After the exclusion criteria were applied, 10 articles were selected including 1,249 patients and 1,361 lower extremities treated for ALI. Acute thrombosis of a limb artery or bypass graft was the main cause of ischemia ranging from 77.7% to 98.0%. The overall technical success rate of the applied method reached 79.3% (1,079 successful cases). Complications of any type occurred in 358 (28.7%) patients. Of them, 72 (20.1%) experienced a minor complication while 286 (79.9%) had a major life-threatening complication. The need for secondary interventions was 77.8% (935 patients). The death rate during the first month was 4.2% (56 patients), while the percentage of patients who suffered amputation because of a failed thrombolysis during the same period was 11.5% (156 patients). Finally, the survival rate without amputation within 30 days was 88.5% (1.105 out of a total of 1,249 patients studied). Conclusions Results confirm the high direct technical success rate of CDT and the high percentage of patients survived without amputation within 30 days, although major complications are a great disadvantage of the method.

Many Americans associate themselves with their political party in a deep, visceral way. Voter identification with a political party has powerful implications for not just how voters behave, but how there are exposed to and receive information about the world. We describe how this tying of one’s self-concept to a party, which can be analogous to die-hard sports fandom, plays a central role in political cognition. It leads voters identifying with the two parties to perceive the political (and even seemingly apolitical) world in dramatically different ways. We detail the psychological mechanisms by which this party identity produces these distortions and offer examples of the bias that emerges. We conclude by discussing the implications of these phenomena for perpetuating our current hyper-polarized political discourse.

Review of the indications for, and the post-operative complications and mortality rates of endovascular techniques for treating abdominal aortic dissection (AAD). An electronic health database search was performed using PubMed, Medline and EMBASE for publications on AAD. The search yielded multiple case reports, which were not included here, and 9 recent series with sufficient data for analysis. The series included in the review reported data on a total of 208 patients. Of the AADs recorded, 182 were spontaneous (87.5%), 13 traumatic (6.25%) and 13 iatrogenic (6.25%), and the majority were of acute presentation (150 patients, 72%). The mean age of the patients was 62.6 years. Hypertension was the most prevalent risk factor (133 patients, 64%). Concurrent aortic aneurysms were more often associated with spontaneous dissection (56 patients, 27%). Open surgical repair was performed in 54 patients (26%), endovascular repair in 94 (45%) and the treatment was conservative in 60 (29%). The in-hospital mortality was 2% for the endovascular group, 5% for the open repair group and ~7% for those receiving conservative treatment. More complications were reported in the patients treated by open surgery than in those undergoing endovascular repair. Patients with AAD are at considerable risk of complications and in-hospital mortality. Based on current evidence, endovascular treatment appears to be associated with a lower risk of major complications and mortality than open repair or conservative treatment, and the need for secondary intervention is rare.

Changes in the media landscape increasingly put voters in control of the amount and type of political content they consume. We develop a novel experiment to assess the factors that drive this conditional receipt of information. We focus on how party source and tone interact with partisanship to influence the campaign messages voters seek out or avoid, as discretion over self-exposure varies. We randomly expose subjects to comparable positive or negative television ads aired by Democratic or Republican candidates from the 2012 Presidential election, and measure subjects’ propensities to skip, re-watch and share the spots. Partisans avoid out-party ads, albeit asymmetrically: Republicans are more consistent partisan screeners than Democrats. We find more such selectivity as discretion increases, but little evidence that negativity influences self-exposure. Our findings provide greater insight into the forces behind information selectivity, and have important implications for elections in the post-broadcast era.

Novel national survey data (spanning eight years), a parsimonious definition of identity, and a new Implicit Association Test are brought together to examine “implicit party identity” for the first time. This offers the most direct evidence available that voters associate themselves with their party at a visceral level, sometimes in a more or less pronounced way than they realize or report. This pre-introspection, automatic association relates strongly to voter evaluation and interpretation of the political world. Comparisons with standard explicit measures and three key outcomes (affect, differential evaluation, and motivated processing) offer insight regarding the nature, distribution, and measurement of party identification. Explicit and implicit measures largely corroborate each other in distinguishing between Democrats, Republicans, and Independents but deviate in registering partisan intensity. “Leaners” appear closer to partisans than to pure independents, and implicit identity yields a more gradua...

Is party “ownership” of issues and traits manifest in the minds of voters in ways that could generate the oft-hypothesized implications for mass and elite electoral behavior? We specify two ways in which it may be: party reputations refer to the association of a trait or issue with a party; candidate stereotyping requires that party labels prompt differential assignment of attributes or competencies to candidates. We develop a quantitative measure of both ownership types, and apply it to issues and traits. New national survey data provide the first evidence that party reputation ownership exists for issues and traits. New experimental tests reveal evidence of candidate stereotyping for issues, but not traits. Voters associate some traits more with one party, but may not assign them to candidates based upon party label, demonstrating a key difference in the nature and likely implications of issue and trait ownership.

Hypoxic-ischemic encephalopathy (HIE), a serious complication of perinatal asphyxia, is commonly associated with an unfavorable outcome. In-depth research is important not only for the interpretation of the underlying biological alternations but may also provide the basis for the development of novel diagnostic and therapeutic tools. The application of metabolomics in perinatal asphyxia/HIE is a relatively new approach. We performed a narrative, non-systematic review in the literature of metabolomic studies involving newborn animals and humans exposed to hypoxia-ischemia or developing perinatal asphyxia/HIE. Fifteen animal studies, nine studies in human neonates, and two review articles were evaluated. Changes in the metabolomic profile of newborn animals exposed to hypoxia-ischemia and of asphyxiated neonates with HIE are presented in relation to the underlying pathophysiology. The clinical relevance of these findings is further discussed in a comprehensible to the bedside clinician manner. Metabolomics may provide an explanation for the various metabolic alternations occurring in perinatal asphyxia/HIE, elucidate the biological background of the applied therapeutic interventions and promote the development of novel diagnostic-prognostic biomarkers of the disease. HIPPOKRATIA 2017, 21(3): 115-123.

Metabolomics could provide valuable insights into hypoxemic-ischemic encephalopathy (HIE) revealing new disease-associated biochemical derangements. The study aimed to investigate urine metabolic changes in neonates with HIE compared to healthy controls, using targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS).In this prospective, single-center study we enrolled neonates born at ≥ 36 weeks gestation with HIE (HIE group) and healthy controls (control group). We collected urine samples for metabolomic analysis on days one, three, and nine of life.Twenty-one full-term newborns were studied, 13 in the HIE group and eight in the control group. Six of the affected neonates had moderate/severe HIE and seven mild HIE. Therapeutic hypothermia was applied only in four neonates with moderate/severe HIE. Multivariate and univariate statistical analysis showed a clear separation between the HIE and the control groups. Discriminant metabolites involved pyruvic acid, amino acids, acylcarnitines, inositol, kynurenine, hippuric acid, and vitamins.We have identified a specific metabolic profile in neonates with HIE, adding to the existing knowledge on the disease biochemistry that may potentially help in biomarker development. HIPPOKRATIA 2017, 21(2): 80-84.

In this paper, three types of algorithms for LED-TFT -LCD displays' content-aware management are presented. Their aim is to minimize the power consumption of the displays, while simultaneously preserving the quality of the displayed content, utilizing global backlight dimming. The first category of algorithms is developed based on proper camera measurements, while the second is developed via lightmeter measurements. The third category is formed by combining the strengths of the previous two. In contrast to previous approach, these algorithms take into account the different contribution of basic colors to the overall image illuminance and adjust accordingly to accomplish greater resemblance between the original and the processed image. The algorithms were tested assuming various pictures with different color patterns. Our experimental results reveal that a 30% power reduction can be achieved with less than 10% average image distortion.

The popularity of online surveys has increased the prominence of using weights that capture units' probabilities of inclusion for claims of representativeness. Yet, much uncertainty remains regarding how these weights should be employed in the analysis of survey experiments: Should they be used or ignored? If they are used, which estimators are preferred? We offer practical advice, rooted in the Neyman-Rubin model, for researchers producing and working with survey experimental data. We examine simple, efficient estimators for analyzing these data, and give formulae for their biases and variances. We provide simulations that examine these estimators as well as real examples from experiments administered online through YouGov. We find that for examining the existence of population treatment effects using high-quality, broadly representative samples recruited by top online survey firms, sample quantities, which do not rely on weights, are often sufficient. We found that Sample Average Treatment Effect (SATE) estimates did not appear to differ substantially from their weighted counterparts, and they avoided the substantial loss of statistical power that accompanies weighting. When precise estimates of Population Average Treatment Effects (PATE) are essential, we analytically show post-stratifying on survey weights and/or covariates highly correlated with the outcome to be a conservative choice. While we show these substantial gains in simulations, we find limited evidence of them in practice., 26 pages, 4 figures

Although endovascular aneurysm repair (EVAR) in the abdominal aorta has reduced the perioperative mortality when compared with open repair, the need for reintervention after complications such as endoleak may be presented in up to 20% of the cases. Type II endoleak from branch vessels is often benign but can potentially be associated with progressive abdominal aortic aneurysm growth and sac expansion. We present a rare case of a patient who presented with sac expansion and psoas hematoma due to Type II endoleak from “unusual” collaterals of IMA and was treated successfully with endoleak microembolization and percutaneous decompression of the hematoma.

Preterm delivery (PTD) represents a major health problem that occurs in 1 in 10 births. The hypothesis of the present study was that the metabolic profile of different biological fluids, obtained from pregnant women during the second trimester of gestation, could allow useful correlations with pregnancy outcome. Holistic and targeted metabolomics approaches were applied for the complementary assessment of the metabolic content of prospectively collected amniotic fluid (AF) and paired maternal blood serum samples from 35 women who delivered preterm (between 29 weeks + 0 days and 36 weeks +5 days gestation) and 35 women delivered at term. The results revealed trends relating the metabolic content of the analyzed samples with preterm delivery. Untargeted and targeted profiling showed differentiations in certain key metabolites in the biological fluids of the two study groups. In AF, intermediate metabolites involved in energy metabolism (pyruvic acid, glutamic acid, and glutamine) were found to contribute to the classification of the two groups. In maternal serum, increased levels of lipids and alterations of key end-point metabolites were observed in cases of preterm delivery. Overall, the metabolic content of second-trimester AF and maternal blood serum shows potential for the identification of biomarkers related to fetal growth and preterm delivery. © 2017 American Chemical Society.

Although endovascular aneurysm repair is a feasible option for high-risk patients resulting in lower perioperative mortality when compared with open repair, the need for reintervention and long-term follow-up affects its use. The aim of the current report is to present 2 cases of patients with type IIIa endoleak from limb disconnection (one patient with double-bilateral endoleak) combined with a late type II endoleak and symptomatic sac growth treated in our department. We also performed a literature review about type III endoleaks and their treatment options.

It is easy enough to rattle off numerous categories of social identities long of interest to political behavior scholars—race, sex, state or nation, party, ideology, social class, etc. But, a precise definition and measurement strategy for examining these identities is more elusive. This article discusses the conceptual foundations of a recently developed approach to measuring identity and focuses on its specific application as a new measure of partisanship in the United States.

Background The aim of this study is to present our early experience and highlight the technical difficulties associated with the use of fenestrated and branched stent grafts to treat patients with juxtarenal abdominal aortic aneurysm (AAA), pararenal AAA, and thoracoabdominal aortic aneurysms (TAAAs). Methods A prospectively held database maintained at our department was queried for patients who have undergone branched and fenestrated stent grafting for AAA or TAAA treatment. Indication for repair, comorbidity precluding open repair, technical challenges associated with the repair, as well as operative mortality, morbidity, and reintervention rate were evaluated. Results A total of 8 patients underwent repair with a fenestrated or branched stent graft. All patients had aneurysmal degeneration of the juxtarenal aorta, pararenal aorta, and thoracoabdominal aorta not suitable to standard endovascular techniques. Two patients had a prior aortic repair, a failed migrated stent graft, and an old surgical tube graft after an open repair. One patient had a type III TAAA and 1 patient had a postdissection TAAA type I. For all patients, target vessel success rate was 96.4% (27/28) and mean hospital stay was 6.0 days (range 3–21). Thirty-day and 1-year mortality were 0%. Mean follow-up was 23 months (range 7–45). Two endoleaks occurred, 1 type III and 1 type II, which were treated endovascularly. No death or major complication occurred during follow-up. Conclusions Fenestrated and branched endovascular stent grafts can be used to repair juxtarenal AAA, pararenal AAA, and TAAA in patients with significant comorbidities. However, several technical challenges have to be overcome due to the unique complex aortic pathology of each patient.

Despite the available monitor and control functionalities, the timely reconfiguration of the modern power grids is not always feasible, due to the inherent inertia of the power elements. Therefore, especially in the case of abrupt phenomena (e.g. loss of power lines), the power grids tend to suffer from severe cascade effects, since the triggering failure is usually followed by successive overloads. Additionally, the grid’s efficient reaction is further restrained by the performance of the underlying ICT system, i.e. delays in the reception of the monitor/control information. The present paper introduces a novel framework for assessing the controllability of ICT-enabled power grids. Assuming structural failures, the proposed methodology quantifies the system’s ability to be readjusted in a way that ceases the progressing damage and re-establishes operation within the grid’s physical constraints. The controllability is identified as a function of the overall system’s power and ICT characteristics, without considering any specific control strategy.

In the modern endovascular era, abdominal aortic aneurysm repair is still not free of complications with re-interventions following endovascular aneurysm repair (EVAR) being more common than with open surgical repair. A variety of endovascular, open surgical and combined techniques were described according to the anatomical considerations and general health of the patient to achieve the best possible result after these complications. In cases of type Ib endoleak following aorto-uni-lateral EVAR for an abdominal aortic aneurysm, the use of the internal branched device (IBD) constitutes a safe and effective technique.

Political parties can provide valuable information to voters by cultivating distinct associations between their labels, issue priorities, policies and group traits. Yet, there is considerable debate over which associations voters incorporate, and whether these are accurate. In this study, we develop a novel conjoint classification experiment designed to map voters’ partisan associative networks. We ask respondents to ‘guess’ the party and ideology of hypothetical candidates given fully randomized issue priorities and biographical details. This inferential approach minimizes the biasing effects of partisan boosting in measuring the relative associations voters make between attributes and parties, and the impact these mappings have on candidate evaluations. We find voters consistently link many issues with party and ideological labels, but agree far less on associations with candidate attributes. Our study highlights important heterogeneity in the information value of party reputations, with implications for theories of democratic competence and empirical findings emerging from candidate-vignette designs.

Rheumatoid arthritis is a progressive, highly debilitating disease where early diagnosis, enabling rapid clinical intervention, would provide obvious benefits to patients, healthcare systems, and society. Novel biomarkers that enable noninvasive early diagnosis of the onset and progression of the disease provide one route to achieving this goal. Here a metabolic profiling method has been applied to investigate disease development in the Tg197 arthritis mouse model. Hind limb extract profiling demonstrated clear differences in metabolic phenotypes between control (wild type) and Tg197 transgenic mice and highlighted raised concentrations of itaconic acid as a potential marker of the disease. These changes in itaconic acid concentrations were moderated or indeed reversed when the Tg197 mice were treated with the anti-hTNF biologic infliximab (10 mg/kg twice weekly for 6 weeks). Further in vitro studies on synovial fibroblasts obtained from healthy wild-type, arthritic Tg197, and infliximab-treated Tg197 transgenic mice confirmed the association of itaconic acid with rheumatoid arthritis and disease-moderating drug effects. Preliminary indications of the potential value of itaconic acid as a translational biomarker were obtained when studies on K4IM human fibroblasts treated with hTNF showed an increase in the concentrations of this metabolite. © 2016 American Chemical Society.

The control plane of the Internet relies entirely on BGP as the interdomain routing protocol to maintain and exchange routing information between large network providers and their customers. However, an intrinsic vulnerability of the protocol is its inability to validate the integrity and correctness of routing information exchanged between peer routers. As a result, it is relatively easy for people with malicious intent to steal legitimate IP blocks through an attack known as prefix hijacking, which essentially consists of injecting bogus routing information into the system to redirect or subvert network traffic. In this article, we give a short survey of visualization methods that have been developed for BGP monitoring, in particular for the identification of prefix hijacks. Our goal is to illustrate how network visualization has the potential to assist an analyst in detecting abnormal routing patterns in massive amounts of BGP data. Finally, we present an analysis of a real validated case of prefix hijacking, which took place between April and August 2011. We use this hijack case study to illustrate the ongoing work carried out in VIS-SENSE, a European research project that leverages visual analytics to develop more effective tools for BGP monitoring and prefix hijack detection.

Published and informal assessments of the prospects for neuroimaging in political science have tended to range from overexuberant to reflexively dismissive. We seek to present a cautious but fair middle ground in considering this new methodology, primarily from an epistemological perspective. Our examination centers on the relationship between two levels of analysis, focusing on the potential for connection between behavior-based theories of political psychology and cognition and the neural processes and systems involved in generating behaviors and states of mind. We explore the place of each level of analysis on its own, as well as the potential for the fruitful interaction of the two. This analysis brings together opinions and ideas presented by others in various forums and across multiple disciplines, offers a discussion of the the promises and perils of neuroimaging in its application to social science, as well as some practical thoughts regarding its early-stage incorporation into political psychology. We argue in favor of proceeding with more substantial incorporation of neuroimaging into political psychology's methodological arsenal, but note that this will initially require both (1) greater acceptance of work more focused on presenting empirical results than on providing dispositive evidence in broader theoretical debates and (2) a commitment on the part of those conducting this research to refrain from overstating the definitiveness of its theoretical implications. Language: en