1. Long-Term Implications of Atrial Fibrillation in Patients With Degenerative Mitral Regurgitation
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Francesco Grigioni, Giovanni Benfari, Jean-Louis Vanoverschelde, Christophe Tribouilloy, Jean-Francois Avierinos, Francesca Bursi, Rakesh M. Suri, Federico Guerra, Agnés Pasquet, Dan Rusinaru, Emanuela Marcelli, Alexis Théron, Andrea Barbieri, Hector Michelena, Siham Lazam, Catherine Szymanski, Vuyisile T. Nkomo, Alessandro Capucci, Prabin Thapa, Maurice Enriquez-Sarano, R. Suri, M.A Clavel, J. Maalouf, H. Michelena, M. Enriquez-Sarano, C. Tribouilloy, F. Trojette, C. Szymanski, D. Rusinaru, G. Touati, J.P. Remadi, F. Guerra, A. Capucci, F. Grigioni, A. Russo, E. Biagini, F. Pasquale, M. Ferlito, C. Rapezzi, C. Savini, G. Marinelli, D. Pacini, G.D. Gargiulo, R. Di Bartolomeo, J. Boulif, C. de Meester, G. El Khoury, B. Gerber, S. Lazam, A. Pasquet, P. Noirhomme, D. Vancraeynest, J-L. Vanoverschelde, J.F. Avierinos, F. Collard, A. Théron, G. Habib, A. Barbieri, F. Bursi, F. Mantovani, R. Lugli, M.G. Modena, G. Boriani, L. Bacchi-Reggiani, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, University of Balamand [Liban] (UOB), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Grigioni, Francesco, Benfari, Giovanni, Vanoverschelde, Jean-Loui, Tribouilloy, Christophe, Avierinos, Jean-Francoi, Bursi, Francesca, Suri, Rakesh M., Guerra, Federico, Pasquet, Agné, Rusinaru, Dan, Marcelli, Emanuela, Théron, Alexi, Barbieri, Andrea, Michelena, Hector, Lazam, Siham, Szymanski, Catherine, Nkomo, Vuyisile T., Capucci, Alessandro, Thapa, Prabin, Enriquez-Sarano, Maurice, Suri, R., Clavel, M.A., Maalouf, J., Michelena, H., Enriquez-Sarano, M., Tribouilloy, C., Trojette, F., Szymanski, C., Rusinaru, D., Touati, G., Remadi, J.P., Guerra, F., Capucci, A., Grigioni, F., Russo, A., Biagini, E., Pasquale, F., Ferlito, M., Rapezzi, C., Savini, C., Marinelli, G., Pacini, D., Gargiulo, G.D., Di Bartolomeo, R., Boulif, J., de Meester, C., El Khoury, G., Gerber, B., Lazam, S., Pasquet, A., Noirhomme, P., Vancraeynest, D., Vanoverschelde, J.-L., Avierinos, J.F., Collard, F., Théron, A., Habib, G., Barbieri, A., Bursi, F., Mantovani, F., Lugli, R., Modena, M.G., Boriani, G., Bacchi-Reggiani, L., University of Balamand - UOB (LIBAN), UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, and UCL - (SLuc) Service de pathologie cardiovasculaire
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Male ,atrial fibrillation ,mitral regurgitation ,mitral repair ,percutaneous treatment ,prognosis ,surgery ,Aged ,Aged, 80 and over ,Atrial Fibrillation ,Cohort Studies ,Female ,Humans ,Middle Aged ,Mitral Valve Insufficiency ,Prevalence ,Registries ,Cardiology and Cardiovascular Medicine ,030204 cardiovascular system & hematology ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Sinus rhythm ,030212 general & internal medicine ,ComputingMilieux_MISCELLANEOUS ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Ejection fraction ,Mitral repair ,Absolute risk reduction ,Atrial fibrillation ,Prognosis ,3. Good health ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Cardiology ,medicine.symptom ,prognosi ,medicine.medical_specialty ,Asymptomatic ,Article ,NO ,03 medical and health sciences ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,International database ,Internal medicine ,medicine ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,In patient ,Mitral regurgitation ,business.industry ,medicine.disease ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Surgery ,business ,Percutaneous treatment - Abstract
BACKGROUND: Scientific guidelines consider atrial fibrillation (AF) complicating degenerative mitral regurgitation (DMR) a debated indication for surgery. OBJECTIVES: This study analyzed the prognostic/therapeutic implications of AF at DMR diagnosis and long-term. METHODS: Patients were enrolled in the MIDA (Mitral Regurgitation International Database) registry, which reported the consecutive, multicenter, international experience with DMR due to flail leaflets echocardiographically diagnosed. RESULTS: Among 2,425 patients (age 67 ± 13 years; 71% male, 67% asymptomatic, ejection fraction 64 ± 10%), 1,646 presented at diagnosis with sinus rhythm (SR), 317 with paroxysmal AD, and 462 with persistent AF. Underlying clinical/instrumental characteristics progressively worsened from SR to paroxysmal to persistent AF. During follow-up, paroxysmal and persistent AF were associated with excess mortality (10-year survival in SR and in paroxysmal and persistent AF was 74 ± 1%, 59 ± 3%, and 46 ± 2%, respectively; p < 0.0001), that persisted 20 years post-diagnosis and independently of all baseline characteristics (p values
- Published
- 2019
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